Dynamin-dependent Membrane Drift Recruits AMPA Receptors to Dendritic Spines

Name: Work Video:
Duration: 3 min 30 s
Frédéric Jaskolski; Belen Mayo-Martin; David E. Jane; Jeremy M. Henley
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2229, 2240, 2356, 2368, 2429, 2615, 2722, 2824, 2834, 3006, 3061, 3157, 3213, 3239, 3320, 3377, 3381, 3442, 3470, 3487, 3755, 3764, 3873, 3888, 3977, 4056, 4142, 4232, 4312, 4402, 4420, 4437], 'regulate': [16, 183], 'synaptic': [17, 95, 165, 184, 262, 332, 399, 486, 541, 597, 621, 1055, 1282, 3325, 3333, 3982, 4043], 'transmission.': [18, 185], 'Here': [19, 186, 1122], 'we': [20, 187, 947, 1123, 1255, 2857, 2974, 2989, 3365, 3560, 3685, 3694, 3726, 4208, 4426], 'show': [21, 188, 1256, 3618, 3946], 'that': [22, 37, 70, 122, 134, 189, 204, 237, 289, 301, 433, 654, 703, 752, 800, 901, 913, 951, 992, 1034, 1090, 1181, 1204, 1232, 1248, 1552, 2337, 2836, 3141, 3507, 3586, 3647, 3663, 3684, 3759, 3781, 3850, 3947, 4396, 4428], 'de': [23, 190, 3498, 3979], 'novo': [24, 191, 3499, 3980], 'exocytosis': [25, 192, 1093, 3244, 3471, 3649, 3678, 3718], 'the': [27, 33, 47, 66, 92, 106, 194, 200, 214, 233, 259, 273, 367, 394, 402, 536, 550, 573, 579, 630, 641, 660, 664, 708, 712, 759, 763, 787, 804, 808, 816, 889, 893, 910, 917, 1000, 1007, 1042, 1050, 1182, 1206, 1213, 1221, 1227, 1257, 1264, 1268, 1271, 1295, 1313, 1323, 1334, 1337, 1342, 1347, 1361, 1385, 1465, 1517, 1521, 1526, 1532, 1535, 1539, 1547, 1553, 1562, 1569, 1624, 1635, 1679, 1682, 1685, 1690, 1694, 1703, 1707, 1744, 1747, 1751, 1758, 1775, 1778, 1790, 1799, 1804, 1807, 1811, 1818, 1826, 1830, 1873, 1878, 2029, 2038, 2109, 2203, 2226, 2250, 2260, 2270, 2292, 2299, 2302, 2306, 2314, 2321, 2343, 2366, 2371, 2374, 2378, 2386, 2431, 2437, 2492, 2495, 2505, 2539, 2561, 2570, 2574, 2577, 2582, 2591, 2601, 2610, 2617, 2623, 2626, 2629, 2634, 2638, 2641, 2647, 2650, 2659, 2664, 2674, 2677, 2689, 2692, 2702, 2756, 2761, 2826, 2847, 2866, 2958, 2969, 2991, 3002, 3007, 3021, 3040, 3044, 3058, 3062, 3072, 3129, 3187, 3191, 3201, 3214, 3219, 3234, 3329, 3384, 3403, 3462, 3473, 3483, 3488, 3512, 3593, 3596, 3605, 3609, 3624, 3658, 3680, 3696, 3700, 3711, 3717, 3723, 3732, 3744, 3748, 3756, 3787, 3797, 3835, 3859, 3876, 3882, 3889, 3892, 3948, 3954, 3960, 3965, 3975, 3996, 4038, 4049, 4057, 4178, 4228, 4259, 4280, 4288, 4299, 4305, 4313, 4326, 4411, 4438, 4442, 4445, 4454, 4456, 4463, 4469, 4472, 4475, 4479, 4486], 'GluR2': [28, 195, 1141, 2242, 3126, 3220, 3297], 'AMPAR': [29, 196, 598, 914, 1145, 1197, 3221, 3229, 3648, 3999], 'subunit': [30, 197, 618, 3222, 3230], 'occurs': [31, 198, 3650, 4045], 'shaft': [35, 67, 202, 234, 714, 911, 1223, 2205, 2217, 2220, 2261, 2571, 2578, 2993, 3513, 3522, 3569, 3598, 3613, 3659, 4051, 4443], 'new': [38, 205, 792, 1277, 1291, 1736, 3587, 3668, 3720, 4041], 'AMPARs': [39, 62, 110, 155, 206, 229, 277, 322, 480, 534, 577, 622, 634, 655, 704, 753, 793, 1056, 1585, 1648, 3588, 3670, 3795, 3952, 3972, 4044], 'diffuse': [40, 207, 669, 2340, 4233], 'into': [41, 88, 144, 208, 255, 311, 758, 955, 1226, 2587, 3592, 3604, 4407, 4462], 'by': [43, 118, 164, 210, 285, 331, 430, 632, 1160, 1201, 1267, 1538, 2027, 2333, 2447, 2487, 2764, 2876, 3053, 3438, 3494, 3671, 4053], 'lateral': [44, 54, 77, 100, 136, 211, 221, 244, 267, 303, 801, 964, 1097, 1153, 1192, 1246, 2510, 3382, 3672, 4054], 'diffusion': [45, 78, 101, 137, 212, 245, 268, 304, 802, 902, 921, 965, 1098, 1154, 1247, 1259, 1287, 1528, 1572, 1867, 2512, 3673, 4055, 4070, 4145, 4272, 4282, 4290, 4308, 4328, 4421, 4449, 4483], 'in': [46, 111, 213, 278, 362, 401, 479, 531, 549, 586, 596, 659, 707, 803, 812, 922, 1107, 1112, 1135, 1147, 1157, 1394, 1618, 1678, 1757, 1803, 1940, 1945, 1957, 2100, 2102, 2119, 2137, 2232, 2296, 2361, 2399, 2548, 2560, 2668, 2725, 2737, 2843, 2863, 2865, 2900, 2982, 3020, 3036, 3206, 3294, 3324, 3369, 3407, 3454, 3459, 3461, 3509, 3558, 3577, 3623, 3629, 3642, 3699, 3722, 3731, 3774, 3846, 3858, 3953, 3974, 4001, 4036, 4146, 4210, 4213, 4359, 4385, 4422], 'membrane.': [48, 215], 'However,': [49, 216, 4133], 'membrane': [50, 132, 141, 158, 217, 299, 308, 325, 581, 662, 710, 761, 806, 952, 968, 1100, 1109, 1183, 1215, 1231, 1292, 2257, 2363, 2511, 2970, 3009, 3197, 3463, 3594, 3661, 4094, 4138, 4303, 4397], 'topology': [51, 218, 1101, 1184, 4139, 4398, 4500], 'restricts': [52, 219], 'this': [53, 220, 2837, 3037, 3394, 3555, 3840, 3990, 4429, 4436], 'diffusion.': [55, 222, 1193, 4405, 4433], 'We': [56, 223, 1150, 4434], 'therefore': [57, 224, 2552], 'investigated': [58, 225, 3615], 'which': [59, 226, 633, 886, 1821, 1829, 3444, 3551, 4037, 4214], 'mechanisms': [60, 227], 'recruit': [61, 228, 1290], 'from': [65, 232, 1217, 1689, 1774, 1839, 1872, 1887, 1927, 2225, 2291, 2328, 2342, 2962, 3057, 3067, 3637, 3674, 3911, 4275, 4410], 'demonstrated': [69, 236], 'inhibition': [71, 238], 'dynamin': [73, 119, 240, 286, 380, 1162], 'GTPase': [74, 241, 1163], 'activity': [75, 242, 1164, 1283], 'reduced': [76, 243], 'membrane-anchored': [80, 247, 350, 883, 2022], 'green': [81, 248, 351, 3138], 'fluorescent': [82, 249, 352, 2039, 2335, 3139, 3152], 'protein': [83, 142, 250, 309, 953, 1003, 1110, 1533, 1952, 2336, 2379, 3140, 4144, 4460], 'super-ecliptic': [85, 252, 383, 1139, 1971], 'pHluorin': [86, 253, 1972, 3132], '(SEP)-GluR2': [87, 254, 1973], 'spines.': [89, 112, 145, 256, 279, 312, 1113, 2872, 3606, 3863], 'In': [90, 257, 694, 945, 1237, 1494, 2712, 2987, 3186, 3357, 4298, 4323, 4383], 'addition,': [91, 258, 946], 'activation': [93, 260, 915, 1195, 2821], 'N-methyl-d-aspartate': [96, 263], '(NMDA)': [97, 264], 'enhanced': [99, 266], 'SEP-GluR2': [103, 270, 2503, 3401, 3566, 3742, 3909], 'increased': [105, 272], 'number': [107, 274, 616, 1674, 1791, 1800, 2251, 3331, 3611, 3949], 'endogenous': [109, 276], 'NMDA-invoked': [114, 281], 'effects': [115, 282], 'were': [116, 283, 1301, 1307, 1351, 1358, 1401, 1482, 1614, 1631, 1762, 1925, 1959, 2114, 2147, 2162, 2188, 2200, 2222, 2238, 2265, 2383, 2427, 2466, 2559, 2585, 2670, 2716, 2751, 2775, 2805, 2917, 2947, 3086, 3112, 3119, 3387, 4220, 4393], 'prevented': [117, 284], 'inhibition,': [120, 287], 'suggesting': [121, 288, 4395], 'activity-dependent': [123, 290, 574], 'dynamin-mediated': [124, 291], 'endocytosis': [125, 292, 1035, 1091, 1269], 'within': [126, 293, 906, 1044, 1270, 3472, 3657, 3834], 'generates': [128, 295], 'a': [129, 149, 296, 316, 583, 594, 996, 1002, 1202, 1243, 1276, 1326, 1365, 1375, 1388, 1478, 1485, 1489, 1495, 1498, 1639, 1710, 1722, 1735, 1740, 1816, 1823, 2180, 2211, 2392, 2469, 2473, 2484, 2765, 2770, 2777, 2840, 2877, 2885, 2995, 3014, 3079, 3134, 3224, 3240, 3370, 3439, 3518, 3562, 3632, 3728, 3777, 3853, 3870, 3968, 4034, 4239, 4248, 4417], 'net': [130, 297], 'inward': [131, 298], 'drift': [133, 300], 'overrides': [135, 302], 'barriers': [138, 305, 1288], 'enhance': [140, 307], 'delivery': [143, 310, 790], 'These': [146, 313, 1273, 2219, 2347, 3944, 4346], 'results': [147, 314, 1241, 1274, 4032, 4347], 'provide': [148, 315, 1275], 'novel': [150, 317], 'mechanistic': [151, 318, 1278], 'explanation': [152, 319, 1279], 'how': [154, 321, 1152, 1281], 'other': [157, 324, 1238], 'proteins': [159, 326, 483, 1262, 1293, 2349, 3198, 4075, 4095], 'recruited': [161, 328], 'activity.': [166, 333], '3The': [335], 'abbreviations': [336], 'used': [337, 1124, 2189, 2537, 2614, 2897, 2907], 'are:': [338], 'AMPA,': [339], 'α-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate;': [340], 'NMDA,': [341, 2785], 'N-methyl-d-aspartate;': [342], 'NMDAR,': [343], 'NMDA': [344], 'receptor;': [345], 'PSD,': [346], 'postsynaptic': [347, 437, 533, 580], 'density;': [348], 'mGFP,': [349], 'protein;': [353], 'FRAP,': [354, 2283, 2746, 2901], 'fluorescence': [355, 360, 2293, 2325, 2567, 2593, 2706, 2864, 3004, 3460, 3567, 3575, 3698, 3734, 3767, 3860, 3879, 3910], 'recovery': [356, 1127, 2294, 2327, 2369, 2669, 2848, 2964, 3379, 3458, 3564, 3576, 3880], 'after': [357, 1128, 2193, 2311, 2326, 2483], 'photobleaching;': [358, 363], 'FLIP,': [359], 'loss': [361, 1134, 3047, 3075], 'ΔFLIP,': [364], 'difference': [365, 2300, 2624, 2648], 'between': [366, 1116, 1555, 2301, 2625, 2649, 3735, 4441, 4474], 'means': [368], 'early': [370, 3705], 'late': [372, 3188, 3707], 'FLIP': [373, 1132, 2635, 2665, 2683, 2909, 3012, 3016, 3059, 3712, 3749, 3757, 3771, 3883], 'sequences;': [374], 'TTX,': [375], 'tetrodotoxin;': [376], 'DAPV,': [377, 2796], 'd-2-amino-5-phosphonovalerate;': [378], 'Dyn2,': [379], '2;': [381], 'SEP,': [382], 'pHluorin.': [384], 'fundamental': [389], 'importance': [390], 'because': [391, 2846, 3402], 'they': [392, 2558, 3490, 3502], 'mediate': [393, 535], 'majority': [395], 'fast': [397], 'excitatory': [398, 425], 'transmission': [400, 487, 3326], 'mammalian': [403], 'central': [404, 1490, 3701], 'nervous': [405], 'system': [406], '(1Shepherd': [407], 'J.D.': [408], 'Huganir': [409], 'R.L.': [410], 'Annu.': [411, 447, 464, 1412, 4082], 'Rev.': [412, 448, 465, 519, 559, 1413, 4083], 'Cell': [413, 1918, 2281], 'Dev.': [414], 'Biol.': [415, 2072, 3304], '2007;': [416, 739, 1072, 3543, 4018], '23:': [417], '613-643Crossref': [418], 'PubMed': [419, 453, 470, 498, 511, 524, 564, 610, 689, 742, 780, 834, 854, 876, 940, 982, 1023, 1080, 1418, 1434, 1601, 1668, 1861, 1913, 1992, 2016, 2058, 2082, 2940, 3181, 3264, 3314, 3352, 3424, 3546, 3817, 3939, 4026, 4088, 4109, 4128, 4165, 4200, 4378], 'Scopus': [420, 454, 471, 499, 525, 565, 611, 690, 743, 781, 835, 855, 877, 941, 983, 1024, 1081, 1419, 1602, 1669, 1862, 1914, 1993, 2017, 2059, 2083, 2529, 2941, 3182, 3265, 3285, 3315, 3353, 3425, 3547, 3818, 3940, 4027, 4089, 4110, 4129, 4166, 4201, 4379], '(784)': [421], 'Google': [422, 456, 473, 501, 512, 527, 567, 613, 692, 745, 783, 837, 857, 879, 943, 985, 1026, 1083, 1421, 1435, 1604, 1671, 1864, 1916, 1995, 2019, 2061, 2085, 2531, 2943, 3184, 3267, 3287, 3317, 3355, 3427, 3549, 3820, 3942, 4029, 4091, 4112, 4131, 4168, 4203, 4381], 'Scholar).': [423, 474, 528, 568, 614, 693, 746, 784, 880, 944, 1027, 1084, 1605, 1672, 1865, 1917, 2020, 2086, 2532, 2944, 3185, 3288, 3356, 3428, 3943, 4132, 4204, 4382], 'Most': [424], 'synapses': [426, 673, 3321], 'characterized': [428], 'morphologically': [429], 'contain': [434], 'an': [435, 1319, 1716, 2246, 3024, 3784, 4223, 4253], 'electron-dense': [436], 'density': [438, 1640, 1696, 1934], '(PSD)': [439], 'their': [441, 3675, 3791], 'head': [442, 1451, 1475, 3064, 4266, 4413, 4447, 4471, 4480], '(2Harris': [443, 1408], 'K.M.': [444, 1409, 1424], 'Kater': [445, 1410], 'S.B.': [446, 1411], 'Neurosci.': [449, 493, 520, 560, 738, 825, 872, 978, 1414, 1430, 1664, 1988, 2012, 2054, 2520, 3260, 3276, 3420, 3542, 3813, 3935, 4105, 4374], '1994;': [450, 1415], '17:': [451, 1416], '341-371Crossref': [452, 1417], '(849)': [455, 1420], 'Scholar,': [457, 502, 513, 838, 858, 1422, 1996, 2062, 3268, 4113], '3Nimchinsky': [458], 'E.A.': [459, 4077], 'Sabatini': [460, 4078], 'B.L.': [461, 4079], 'Svoboda': [462, 4080], 'K.': [463, 2516, 3272, 4081], 'Physiol.': [466, 936, 4084], '2002;': [467, 2074, 4085], '64:': [468, 4086], '313-353Crossref': [469, 4087], '(940)': [472, 4090], 'PSD': [475, 642, 764, 817, 1008, 1043], 'is': [476, 593, 797, 903, 960, 995, 1046, 1155, 1188, 1233, 1249, 1789, 1798, 1810, 1817, 1832, 1837, 2330, 2622, 2646, 2822, 2832, 2957, 3133, 3142, 3155, 3223, 3236, 3405, 3956, 4140, 4310, 4330, 4400, 4450], 'highly': [477], 'enriched': [478], 'associated': [482], 'equired': [484], 'for': [485, 791, 1439, 1444, 1450, 1456, 1583, 1646, 1942, 2116, 2124, 2155, 2174, 2269, 2332, 2718, 2807, 2814, 2890, 2898, 2908, 2913, 3103, 3200, 3227, 3524, 4150, 4177, 4337], 'signal': [489, 2707, 3153], 'transduction': [490], '(4Henley': [491], 'J.M.': [492, 976, 1986, 2010, 2052, 2518, 3258, 3274, 3302, 3418, 3811, 3933, 4103, 4372], 'Res.': [494], '2003;': [495, 607, 851, 1598, 3306], '45:': [496], '243-254Crossref': [497], '(47)': [500], '5Henley': [503], 'J.': [504, 737, 776, 850, 935, 977, 1014, 1058, 1429, 1597, 1650, 1663, 1854, 1900, 1906, 1987, 2006, 2011, 2053, 2071, 2933, 3172, 3254, 3259, 3303, 3419, 3541, 3812, 3934, 4004, 4104, 4119, 4158, 4191, 4373], 'Biochem.': [505], 'Soc.': [506], 'Trans.': [507], '2001;': [508, 873, 3344], '29:': [509, 827], '485-488Crossref': [510], '6Kim': [514], 'E.': [515, 823, 1654, 1658, 1902], 'Sheng': [516], 'M.': [517, 736, 860, 868, 1652, 3540], 'Nat.': [518, 558, 871], '2004;': [521, 937, 2013, 2521, 3261, 3277], '5:': [522], '771-781Crossref': [523], '(1256)': [526], 'Activity-evoked': [529], 'changes': [530], 'functional': [532], 'two': [537, 3479], 'main': [538, 2286], 'forms': [539], 'plasticity': [542], 'believed': [543], 'underlie': [545], 'learning': [546], 'memory': [548], 'hippocampus': [551], '(7Neves': [552], 'G.': [553], 'Cooke': [554], 'S.F.': [555], 'Bliss': [556], 'T.V.': [557], '2008;': [561], '9:': [562], '65-75Crossref': [563], '(848)': [566], 'Long': [569], 'term': [570, 591], 'potentiation': [571], 'involves': [572, 1205], 'recruitment': [575, 1198, 1207, 4039], 'concurrent': [584], 'increase': [585, 3730], 'AMPA-mediated': [587], 'transmission,': [588], 'whereas': [589, 2902], 'long': [590, 670], 'depression': [592], 'decrease': [595, 3857], 'function': [599], '(8Malenka': [600], 'R.C.': [601], 'Ann.': [602], 'N.': [603], 'Y.': [604, 866, 3338], 'Acad.': [605], 'Sci.': [606], '1003:': [608], '1-11Crossref': [609], '(275)': [612], 'composition': [619], 'stringently': [624], 'regulated,': [625], 'but': [626, 717, 3571, 3599, 4495], 'despite': [627], 'intense': [628], 'investigation,': [629], 'processes': [631], 'delivered': [636], 'retained': [639], 'remain': [643, 1120], 'controversial.': [644], 'Using': [645, 881], 'photoreactive': [646], 'antagonists': [647], 'electrophysiology,': [649], 'it': [650, 796, 896, 1030, 2831, 3149, 4134, 4458], 'has': [651, 748, 897, 1031], 'been': [652, 750, 899, 1032, 3590, 3762], 'proposed': [653, 1033], 'only': [657, 2903, 3237], 'inserted': [658, 706, 756, 3591], 'plasma': [661, 709, 760, 805, 894, 1209, 3660], 'cell': [665, 3202], 'body': [666], 'laterally': [668], 'distances': [671, 3056], '(9Adesnik': [674], 'H.': [675, 870, 1660], 'Nicoll': [676], 'R.A.': [677, 934], 'England': [678], 'P.M.': [679], 'Neuron.': [680, 1071, 4017], '2005;': [681, 1665], '48:': [682], '977-985Abstract': [683], 'Full': [684, 686, 829, 831, 1018, 1020, 1075, 1077, 1858, 1910, 2077, 2079, 2524, 2526, 2892, 2937, 3176, 3178, 3280, 3282, 3309, 3311, 3347, 3349, 4021, 4023, 4123, 4125, 4162, 4195, 4197], 'Text': [685, 687, 830, 832, 1019, 1021, 1076, 1078, 1859, 1911, 2078, 2080, 2525, 2527, 2938, 3177, 3179, 3281, 3283, 3310, 3312, 3348, 3350, 4022, 4024, 4124, 4126, 4163, 4196, 4198], 'PDF': [688, 833, 1022, 1079, 1860, 1912, 2081, 2528, 2939, 3180, 3284, 3313, 3351, 4025, 4127, 4164, 4199], '(186)': [691], 'direct': [695, 4353], 'contrast,': [696], 'approaches': [697], 'using': [698, 1777, 2091, 2884, 3050, 3078, 3114, 3121, 3291, 3869], 'real-time': [699], 'imaging': [700], 'have': [701, 948, 990, 4416], 'suggested': [702, 751], 'close': [715, 1040, 3754, 4311], 'to,': [716], 'not': [718, 2339, 2557, 2839, 2859, 3143, 3397, 3601, 3617, 3761, 3993, 4415], 'at,': [719], '(10Yudowski': [722, 3526], 'G.A.': [723, 3527], 'Puthenveedu': [724, 3528], 'M.A.': [725, 3529], 'Leonoudakis': [726, 3530], 'D.': [727, 848, 1010, 1595, 1896, 3166, 3531, 4115], 'Panicker': [728, 3532], 'S.': [729, 3163, 3336, 3533], 'Thorn': [730, 3534], 'K.S.': [731, 3535], 'Beattie': [732, 3536], 'E.C.': [733, 3537], 'von': [734, 3538], 'Zastrow': [735, 3539], '27:': [740, 2522, 3278, 3544], '11112-11121Crossref': [741, 3545], '(161)': [744, 3548], 'It': [747], 'also': [749, 898, 3924, 4363], 'could': [754, 3491, 3503], 'be': [755, 2289, 2351, 3436, 3468, 3492, 3504, 4246, 4269], 'directly': [757, 2352, 3603], '(11Gerges': [765], 'N.Z.': [766], 'Backos': [767], 'D.S.': [768], 'Rupasinghe': [769], 'C.N.': [770], 'Spaller': [771], 'M.R.': [772], 'Esteban': [773, 3339], 'J.A.': [774, 3340], 'EMBO': [775, 849, 1596], '2006;': [777, 826, 979, 1015, 1989, 2055, 3421, 3814, 3936, 4106, 4120, 4192, 4375], '25:': [778, 1666], '1623-1634Crossref': [779], '(115)': [782], 'Independent': [785], 'route': [788], 'synapses,': [795], 'well': [798, 1095], 'established': [799], 'allows': [807], 'exchange': [809, 3785], 'out': [814, 957, 1726, 3964, 3995, 4484], '(12Groc': [818], 'L.': [819, 842, 1589], 'Gustafsson': [820], 'B.': [821, 846, 1064, 1428, 1593, 1850, 2929, 4010], 'Hanse': [822], 'Trends': [824], '132-139Abstract': [828], '(89)': [836], '13Tardin': [839], 'C.': [840, 844, 1587, 1591], 'Cognet': [841, 1588], 'Bats': [843, 1590], 'Lounis': [845, 1592], 'Choquet': [847, 1594], '22:': [852, 1599], '4656-4665Crossref': [853, 1600], '(320)': [856, 1603], '14Matsuzaki': [859], 'Ellis-Davies': [861], 'G.C.': [862], 'Nemoto': [863], 'T.': [864, 2519, 3275], 'Miyashita': [865], 'Iino': [867], 'Kasai': [869, 1659], '4:': [874], '1086-1092Crossref': [875], '(1238)': [878], 'palmitoylated': [882], 'GFP': [884], '(mGFP),': [885], 'partitions': [887], 'inner': [890], 'leaflet': [891], 'membrane,': [895, 1210], 'reported': [900], 'significantly': [904, 2686, 4331], 'retarded': [905], 'compared': [908, 962, 3105, 3958, 4286, 4339], 'with': [909, 963, 1169, 1212, 1303, 1471, 1488, 1638, 1693, 1966, 2037, 2130, 2149, 2165, 2179, 2450, 2460, 2729, 2789, 2810, 2949, 3082, 3088, 3517, 3667, 3716, 3794, 3800, 3831, 3913, 3959, 4252, 4287, 4340, 4351], 'increases': [916], 'rates': [918], 'mGFP': [920, 1975, 2187], '(15Richards': [924], 'D.A.': [925], 'De': [926, 1999, 3164, 3247], 'Paola': [927], 'V.': [928], 'Caroni': [929], 'P.': [930, 4189], 'Gahwiler': [931], 'B.H.': [932], 'McKinney': [933], '558:': [938], '503-512Crossref': [939], '(46)': [942], 'shown': [949, 3628, 3845, 4358], 'previously': [950, 1978, 2044, 2921], 'movement': [954, 1146, 1699], 'slow': [961, 3563], 'on': [966, 1173, 1372, 1484, 1608, 1634, 1935, 2385, 2569, 2870, 3128, 3243, 3568, 3595, 3679, 3796, 4048], 'non-spiny': [967, 4301, 4341, 4423], '(16Ashby': [969, 1979, 2045, 3411, 3804, 4096], 'M.C.': [970, 1980, 1998, 2046, 2514, 3246, 3270, 3412, 3805, 3927, 4097, 4366], 'Maier': [971, 1981, 2047, 3413, 3806, 3928, 4098, 4367], 'S.R.': [972, 1982, 2048, 3414, 3807, 3929, 4099, 4368], 'Nishimune': [973, 1983, 2049, 3415, 3808, 3930, 4100, 4369], 'A.': [974, 1012, 1656, 1984, 2050, 2066, 2070, 3416, 3809, 3931, 4101, 4117, 4185, 4187, 4370], 'Henley': [975, 1985, 2009, 2051, 2517, 3257, 3273, 3301, 3417, 3810, 3932, 4102, 4371], '26:': [980, 1990, 2056, 3422, 3815, 3937, 4107, 4376], '7046-7055Crossref': [981, 1991, 2057, 3423, 3816, 3938, 4108, 4377], '(243)': [984, 1994, 2060, 3426, 3819, 3941, 4111, 4380], 'Scholar),': [986, 1436, 3550, 3821, 4030, 4092], 'modeling': [988], 'studies': [989], 'predicted': [991], 'spine': [993, 1228, 1324, 1369, 1378, 1381, 1457, 1680, 1691, 1879, 2583, 2952, 3063, 3822, 3955, 3976, 4058, 4260, 4412, 4446, 4464, 4470, 4487, 4499], 'length': [994, 1467, 1515, 2575, 4264], 'major': [997, 2841], 'determinant': [998], 'time': [1001, 1512, 1522, 1563, 1753, 1768, 1795, 1819, 1874, 2604, 2680, 2695, 2959, 3041, 3708, 3737, 3745, 3769, 3837, 4236], 'takes': [1004], 'reach': [1006], '(17Holcman': [1009], 'Triller': [1011, 4116], 'Biophys.': [1013, 1853, 1905, 2932, 3171, 4118, 4157, 4190], '91:': [1016, 4121], '2405-2415Abstract': [1017, 4122], '(86)': [1025, 4130], 'More': [1028], 'recently,': [1029], 'specialized': [1037], 'endocytic': [1038], 'zones': [1039], 'required': [1047], 'maintain': [1049], 'steady': [1051, 2308], 'state': [1052, 2309], 'complement': [1053], '(18Lu': [1057, 4003], 'Helton': [1059, 4005], 'T.D.': [1060, 4006], 'Blanpied': [1061, 4007], 'T.A.': [1062, 3170, 4008], 'Racz': [1063, 4009], 'Newpher': [1065, 4011], 'T.M.': [1066, 4012], 'Weinberg': [1067, 4013], 'R.J.': [1068, 4014], 'Ehlers': [1069, 4015], 'M.D.': [1070, 4016], '55:': [1073, 4019], '874-889Abstract': [1074, 4020], '(217)': [1082, 4028], 'Taken': [1085], 'together': [1086, 1211], 'these': [1087, 1117, 3455, 3736, 4384], 'findings': [1088], 'suggest': [1089, 1242], 'as': [1094, 1096, 1309, 1360, 1581, 1616, 1644, 1976, 2042, 2267, 2468, 2609, 2919, 2980, 2994, 3233, 3621, 4148], 'may': [1102, 2350], 'all': [1103, 2543, 3826, 3908], 'play': [1104], 'important': [1105, 2833], 'roles': [1106], 'regulating': [1108], 'mobility': [1111, 2372], 'interrelationships': [1115], 'processes,': [1118], 'however,': [1119, 3434], 'unclear.': [1121], 'FRAP': [1125, 1841, 1889, 2271, 4250, 4357], '(fluorescence': [1126, 1133], 'photobleaching)': [1129, 1136], 'multisite': [1131], 'visualize': [1138], 'pHluorin-tagged': [1140], 'real': [1148], 'time.': [1149, 1354, 2597, 2779], 'examined': [1151], 'regulated': [1156], 'both': [1159], 'blocking': [1161], 'stimulating': [1166], 'NMDARs.': [1167], 'Combined': [1168], 'Monte': [1170], 'Carlo': [1171, 1299], 'simulations': [1172, 1300], 'lattices': [1174, 1613], 'fitting': [1175, 1835], 'theoretical': [1176, 1356, 1527, 1571, 1840, 1888, 4289, 4314], 'spines,': [1177, 1464, 2573, 2973], 'our': [1178, 1240, 2844, 3801, 4031, 4352], 'data': [1179, 1620, 2277, 2984, 3636, 3844, 3945, 4173], 'indicate': [1180], 'alone': [1187, 4399], 'sufficient': [1189, 4141, 4401], 'constrain': [1191, 4143], 'NMDAR': [1194, 2820], 'facilitates': [1196], 'process': [1203], 'constituent': [1214], 'proteins,': [1216], 'adjacent': [1218, 3862], 'regions': [1219, 2262, 2497, 3386, 3570, 3614, 3758], 'being': [1224], 'drawn': [1225, 2207], 'replace': [1230], 'internalized': [1234], 'during': [1235, 1706, 2708, 2755, 3039, 3514, 3743, 3770, 3881], 'endocytosis.': [1236], 'words,': [1239], 'mode': [1244], 'neither': [1250], 'free': [1251], 'nor': [1252], 'anomalous.': [1253], 'Rather,': [1254], 'directional': [1258], 'membrane-embedded': [1261], 'toward': [1263, 2436], 'postsynapse': [1265], 'driven': [1266], 'spine.': [1272, 1296], 'can': [1284, 1500, 2288, 3435, 3467, 4245, 4268], 'overcome': [1285], 'topology-induced': [1286], 'Computer': [1297], 'Modeling—Monte': [1298], 'performed': [1302, 1483, 2869, 3113], 'MATLAB': [1304, 3115], 'software.': [1305, 3084, 3123], 'Runs': [1306], 'built': [1308, 1359], 'perturbation/relaxation': [1310, 4243], 'experiments.': [1311], 'At': [1312, 1623], 'initial': [1314, 2853], 'point': [1315, 1626], '(t': [1316, 1627], '=': [1317, 1542, 1628, 1782, 1882, 2882, 2951, 4321], '0),': [1318, 1629], 'area': [1320, 1692, 1759, 1805, 2344, 2971, 2977, 3372, 3464, 4224], 'interest,': [1322], '(or': [1325], 'flat': [1327, 1389, 1486, 1636, 4302, 4342], 'circle)': [1328], 'was': [1329, 1382, 1459, 1468, 1549, 1558, 1565, 1574, 1687, 1725, 1772, 1869, 2025, 2089, 2206, 2254, 2445, 2594, 2684, 2838, 2850, 2874, 2896, 2906, 3018, 3030, 3048, 3076, 3552, 3557, 3783, 3852, 3867, 3886, 4285], 'empty': [1330], 'particles.': [1332], 'During': [1333], 'course': [1335, 3042, 3746], 'experimental': [1338, 4354], 'simulation,': [1339], 'particles': [1340, 1630, 1676, 1701, 4215, 4293, 4492], 'undergoing': [1341, 4216], 'random': [1343, 1496, 1698, 1741, 4218], 'walk': [1344, 1497], 'entering': [1346, 1702, 2504], 'region': [1348, 1637, 2032, 2475, 2506, 3017, 3038, 3060, 3474, 3703, 4440], 'interest': [1350, 1761, 2477, 2508, 3374, 3466, 4226], 'counted': [1352], 'over': [1353, 2596, 3768, 4235, 4490, 4496], 'Briefly,': [1355], 'vertical': [1362], 'concatenation': [1363], 'truncated': [1366], 'sphere': [1367], '(the': [1368, 1377], 'head)': [1370], 'placed': [1371, 2384, 4221], 'top': [1373], 'cylinder': [1376, 2996], 'neck).': [1379], 'Each': [1380, 3864], 'located': [1383], 'center': [1386], 'square': [1390, 1704, 1748], 'field': [1391, 1705, 1728, 1749], '4': [1392], 'μm': [1393, 2167, 2731, 2784, 2791, 2795, 2799], 'length/side': [1395], '(see': [1396, 2273, 3579, 3772, 4362], 'Fig.': [1397, 1621, 2278, 2699, 2985, 3391, 3451, 3580, 3630, 3643, 3775, 3847, 3987, 4174, 4360], '2a).': [1398], 'Spine': [1399, 4060], 'features': [1400], 'assigned': [1402], 'according': [1403, 2095], 'electron': [1405], 'microscopy': [1406], 'observations': [1407, 3803, 4355], '19Harris': [1423], 'Jensen': [1425], 'F.E.': [1426], 'Tsao': [1427], '1992;': [1431], '12:': [1432], '2685-2705Crossref': [1433], '20-250': [1437], 'nm': [1438, 1443, 1449, 1470, 2887], 'neck': [1440, 1445, 1466, 1473, 4261, 4439, 4455, 4476], 'radius,': [1441], '10-2000': [1442], 'length,': [1446], '20-500': [1448], 'radius.': [1452], 'step': [1454, 1523, 1564], 'size': [1455, 3890], 'shaping': [1458], '10': [1460, 2175, 2603, 2631, 2643, 2653, 2661, 2679, 2694, 3033], 'nm.': [1461], 'For': [1462, 1947, 2742, 2801, 3011], 'stubby': [1463], '10-50': [1469], 'equal': [1472], 'radii.': [1476], 'As': [1477, 1709], 'control,': [1479], 'some': [1480], 'runs': [1481], 'lattice': [1487, 1556], 'circle': [1491], 'explored': [1492], 'region.': [1493], 'particle': [1499, 1793, 1802], 'haphazardly': [1501], 'jump': [1502, 1518], 'one': [1504], 'four': [1506], 'possible': [1507, 3480], 'orthogonal': [1508], 'positions': [1509, 1607], 'each': [1511], 'point.': [1513], '(L)': [1519], '(dt)': [1524], 'define': [1525], 'coefficient': [1529, 1573, 1868, 4273, 4283, 4291, 4309, 4329], '(D)': [1530], 'microscopic': [1536, 1570], 'scale': [1537, 1545], 'equation': [1540], 'D': [1541, 1881, 2950], 'L2/4dt.': [1543], 'simulation': [1548], 'set': [1550, 2213, 2234, 2428], 'such': [1551], 'spacing': [1554], 'sites': [1557, 3676], '50': [1559, 2166, 2461, 2730, 2735, 2783, 2794], 'nm,': [1560], '1.250': [1566], 'ms.': [1567, 1766], 'Thus,': [1568, 3210, 3453, 4489], '0.5': [1575], 'μm2/s': [1576], '(=': [1577], '(50': [1578], 'nm)2/4(1.25': [1579], 'ms))': [1580], 'measured': [1582, 3005, 3695], 'mobile': [1584, 3788, 3829], '(13Tardin': [1586], 'Nearest-neighbor': [1606], 'planar,': [1609], 'cylindrical,': [1610], 'spherical': [1612], 'computed': [1615, 1688, 1723, 2948, 4306], 'described': [1617, 1645, 1977, 2043, 2268, 2920, 2981], 'supplemental': [1619, 2276, 2983, 3986, 4172], '1.': [1622], 'start': [1625], 'distributed': [1632], 'randomly': [1633], '20': [1642, 2125, 2719], 'particles/μm2': [1643], 'extra-synaptic': [1647], '(20Tanaka': [1649], 'Matsuzaki': [1651], 'Tarusawa': [1653], 'Momiyama': [1655], 'Molnar': [1657], 'Shigemoto': [1661], 'R.': [1662, 3342], '799-807Crossref': [1667], '(136)': [1670], 'expected': [1677], 'end': [1683], 'run': [1686], 'above': [1695], 'run.': [1708], 'boundary': [1711], 'rule': [1712, 3994], 'mimic': [1715], 'infinite': [1717, 4254], 'pool': [1718, 3431, 3896, 4255], 'particles,': [1720, 4257], 'when': [1721, 2673], 'position': [1724, 1742], '(IxI': [1729], 'or': [1730, 1974, 2353, 2359, 2458, 2556, 2739, 2793, 3501, 3654, 4390], 'IyI': [1731], '>': [1732], '2': [1733], 'mm),': [1734], 'trajectory': [1737], 'started': [1738], 'along': [1743], 'edge': [1745], 'following': [1752, 1779, 2245], 'step.': [1754], 'Particle': [1755], 'counts': [1756], 'done': [1763, 2724], 'every': [1764], '100': [1765, 2790], 'constant': [1769, 1875, 2960], 'relaxation': [1771, 4277], 'extracted': [1773, 2961, 4274], 'curve': [1776, 1836, 2295], 'fit,': [1780], 'n(t)': [1781, 1788], 'N(t/τ)a1': [1783], '+': [1784], '(t/τ)a(Eq.': [1785], '1)': [1786, 4175], 'where': [1787, 2607, 2955, 4258, 4448], 't,': [1796], 'N': [1797, 3216], 'equilibrium,': [1808, 1814], 't': [1809, 2956], 'half-time': [1812, 2367], 'exponent,': [1820], 'gives': [1822], 'measure': [1824, 2566, 2968], 'degree': [1827], 'motion': [1831], 'restricted.': [1833, 4451], 'This': [1834, 2499, 3429, 3645, 4242], 'adapted': [1838, 1886], 'experiments': [1842, 1890, 1965, 2272, 2465, 2723, 2868, 3639, 4212], '(21Feder': [1843, 2922], 'T.J.': [1844, 2923], 'Brust-Mascher': [1845, 2924], 'I.': [1846, 2925], 'Slattery': [1847, 2926], 'J.P.': [1848, 2927], 'Baird': [1849, 2928], 'Webb': [1851, 1903, 2930], 'W.W.': [1852, 1904, 2931], '1996;': [1855, 2934], '70:': [1856, 2935], '2767-2773Abstract': [1857, 2936], '(394)': [1863, 2942], 'then': [1870, 2163, 2223, 2774], 'calculated': [1871, 3008], '(t)': [1876], 'area,': [1880], '0.88(spine': [1883], 'area/π)4τ(Eq.': [1884], '2)': [1885], 'under': [1891, 2380, 2579, 3159], 'uniform': [1892], 'disk': [1893], 'illumination': [1894], '(22Axelrod': [1895], 'Koppel': [1897], 'D.E.': [1898], 'Schlessinger': [1899], 'Elson': [1901], '1976;': [1907], '16:': [1908], '1055-1069Abstract': [1909], '(2080)': [1915], 'Culture,': [1919], 'Viral': [1920], 'Transduction,': [1921], 'Transfection—Hippocampal': [1923], 'cultures': [1924, 1953], 'prepared': [1926], 'embryonic': [1928], '(E18)': [1929], 'rats,': [1930], 'plated': [1931], 'high': [1933], 'glass': [1936], 'coverslips': [1937], 'grown': [1939], 'culture': [1941], '15-25': [1943], 'days': [1944, 1956], 'vitro.': [1946], 'viral': [1948], 'recombinant': [1951], '21-25': [1955], 'vitro': [1958, 2103], 'transduced': [1960, 3359], '24-36': [1961], 'h': [1962], 'prior': [1963, 2721], 'attenuated': [1967], 'Sindbis': [1968, 3292], 'virus': [1969, 3293], 'containing': [1970, 2403], '23Ashby': [1997], 'La': [2000, 3248], 'Rue': [2001, 3249], 'S.A.': [2002, 3250], 'Ralph': [2003, 3251], 'G.S.': [2004, 3252], 'Uney': [2005, 3253], 'Collingridge': [2007, 3255], 'G.L.': [2008, 3256], '24:': [2014, 3262], '5172-5176Crossref': [2015, 3263], '(192)': [2018, 3266], 'probe': [2023, 2040], '(mGFP)': [2024], 'produced': [2026, 3120], 'fusing': [2028], 'coding': [2030], 'N-terminal': [2031], 'GAP-43': [2034], '(palmitoylation': [2035], 'site)': [2036], 'eGFP': [2041], '24Leaney': [2063], 'J.L.': [2064], 'Benians': [2065], 'Graves': [2067], 'F.M.': [2068], 'Tinker': [2069], 'Chem.': [2073, 3305], '277:': [2075], '28803-28809Abstract': [2076], '(21)': [2084], 'Dynamin/mGFP': [2087], 'co-transfection': [2088], 'achieved': [2090], 'Lipofectamine': [2092], '2000': [2093], 'transfection': [2094], "manufacturer's": [2097], 'protocols': [2098], '(invitrogen)': [2099], '15-19-day': [2101], 'neurons.': [2104], 'Surface': [2105], 'Immunostaining': [2106], 'Analysis—Following': [2108], 'appropriate': [2110], 'pharmacological': [2111], 'treatments,': [2112], 'neurons': [2113, 2146, 3362], 'washed': [2115, 2813], '1': [2117, 2798, 2815], 'min': [2118, 2126, 2157, 2176, 2720, 2759, 2809], 'recording': [2120, 2138, 2401, 2452, 2726, 3066], 'solution': [2121, 2154, 2402, 2453, 2710, 2727], 'incubated': [2123, 2164, 2717, 2806], 'room': [2128, 2159], 'temperature': [2129], '5': [2131, 2408, 2490, 2758], 'mg/ml': [2132], 'anti-GluR2': [2133], '(N-terminal,': [2134], 'Zymed': [2135], 'Laboratories)': [2136], 'solution.': [2139], 'After': [2140], 'washing': [2141], 'remove': [2143], 'excess': [2144], 'antibody,': [2145], 'fixed': [2148], 'heated': [2150, 2387], 'paraformaldehyde,': [2151], '4%': [2152], 'sucrose': [2153], '15': [2156], 'temperature.': [2160], 'Neurons': [2161, 2382], 'glycine': [2168, 2792], '0.3%': [2170], 'bovine': [2171], 'serum': [2172], 'albumin': [2173], 'before': [2177], 'incubation': [2178], 'Cy3-conjugated': [2181], 'secondary': [2182], 'antibody.': [2183], 'Confocal': [2184], 'images': [2185], 'produce': [2191, 2210, 4403], 'masks': [2192, 2199, 2215, 2221, 2228], 'automated': [2194, 2247], 'intensity': [2195, 2248], 'thresholding': [2196], '(ImageJ).': [2197], 'duplicated': [2201], 'manually': [2208, 3054], 'first': [2212, 2602, 2642, 2693, 2757], 'defining': [2216], 'regions.': [2218], 'subtracted': [2224], 'original': [2227], 'reveal': [2230], 'another': [2233], 'masks.': [2236], 'Masks': [2237], 'applied': [2239], 'corresponding': [2241], 'images,': [2243], 'threshold,': [2249], 'puncta': [2253], 'measured.': [2255], 'areas': [2258, 4343], 'assessed': [2266], 'below': [2274], '2).': [2279], 'Live': [2280], 'Imaging,': [2282], 'FLIP—Two': [2285], 'parameters': [2287], 'determined': [2290], 'FRAP.': [2297, 3515], 'First': [2298], 'pre-photobleaching': [2303], 'level': [2304, 2310, 2323], 'recovered': [2307], 'bleaching': [2312, 2493, 3029], 'reflects': [2313], 'immobile': [2315, 2348], 'fraction': [2316, 2376, 3789, 3917], 'protein.': [2318], 'That': [2319], 'is,': [2320], 'lower': [2322], 'photobleaching': [2329, 2471, 2541, 2899, 3158, 3765], 'accounted': [2331], 'bleached': [2334, 2754], 'does': [2338, 3396, 3992], 'away': [2341], 'photobleaching.': [2346], 'indirectly': [2354], 'tethered': [2355], 'cytoskeletal': [2357], 'elements': [2358], 'restricted': [2360], 'confined': [2362], 'compartments.': [2364], 'Secondly,': [2365], 'indicates': [2370], 'diffusible': [2375], 'investigation.': [2381], 'stage': [2388], '(37': [2389], '°C)': [2390], 'confocal': [2393, 2534], 'Zeiss': [2394], 'Axiovert': [2395], 'microscope': [2396], 'bathed': [2398], 'extracellular': [2400, 2451, 3194, 3215], '(in': [2404], 'mm):': [2405], '140': [2406], 'NaCl,': [2407], 'KCl,': [2409, 2788], '1.8': [2410], 'CaCl2,': [2411], '0.8': [2412], 'MgCl2,': [2413], '25': [2414], 'HEPES,': [2415], '0.9': [2417], 'g/liter': [2418], 'glucose': [2419], '(pH': [2420], '7.4).': [2421], 'Pinhole': [2422], 'settings': [2423, 2536], 'z': [2425, 2438], 'focus': [2426], 'limit': [2430], 'contribution': [2432], 'projecting': [2435], 'axis': [2439], '(Airy': [2440], '1-2).': [2441], 'pH': [2443, 2456, 2550, 2709, 3208, 3242, 3448], 'sensitivity': [2444], 'confirmed': [2446], 'perfusing': [2448], 'cells': [2449, 2715, 2804], 'buffered': [2454], '6.0': [2457], 'complemented': [2459, 2728], 'mm': [2462, 2736, 2787], 'NH4Cl.': [2463], 'FRAP-FLIP': [2464, 3865], 'designed': [2467], 'single': [2470], 'user-designed': [2474], '(central': [2478], 'flanking': [2480, 2496, 3385], 'areas)': [2481], 'followed,': [2482], '1-min': [2485, 2771], 'recovery,': [2486, 3620], 'maintaining': [2488], '(for': [2489], 'min)': [2491], 'only.': [2498], 'protocol': [2500, 3395], 'bleaches': [2501], 'any': [2502, 2861, 3457, 3574, 3619], 'via': [2509, 4046], '(25Ashby': [2513], 'Ibaraki': [2515, 3271], '257-261Abstract': [2523, 3279], '(103)': [2530, 3286], 'power': [2535, 2893, 2905, 2912], 'ensured': [2538], 'effective': [2540], 'susceptible': [2544], '(i.e.': [2546, 4227], 'those': [2547], 'neutral': [2549, 3241], 'emitting': [2553], 'fluorescence)': [2554], 'whether': [2555, 4137], 'plane': [2562], 'acquisition.': [2564], 'To': [2565, 2966, 3682, 4205], 'fluctuations': [2568], 'investigation': [2580], 'heads': [2584], 'divided': [2586], '20-pixel': [2588], 'regions,': [2589, 4424], 'mean': [2592, 2599, 2627, 2639, 2651, 2675, 2690], 'recorded': [2595, 3049], 'points': [2605, 2681, 2696, 3709], '(Fi)': [2606], 'considered': [2608, 2671, 2990, 4247], 'base': [2611], 'line': [2612], 'normalize': [2616], 'entire': [2618], 'experiment': [2619, 2762, 3750, 3866, 4251], '(F/Fi).': [2620], 'ΔFLIP': [2621], 'last': [2630, 2652, 2660, 2678], 'measures': [2632, 2654, 2662], 'sequence': [2636, 3884], 'measures.': [2644], 'ΔNH4Cl': [2645], 'NH4Cl': [2656], 'application': [2657], 'sequence.': [2666], 'Differences': [2667], 'valid': [2672], 'statistically': [2685], 'greater': [2687], 'than': [2688, 3690], 'FLIP.': [2698], '1f': [2700], 'represents': [2701], 'mean-fold': [2703], 'fluctuation': [2704], 'switching.': [2711], 'dynasore': [2713, 2732], 'experiments,': [2714, 3013, 3456, 4387], '(from': [2733], 'stock': [2734], 'DMSO)': [2738], '1/1000': [2740], 'DMSO.': [2741], 'paired': [2743], 'recordings': [2744], 'segments': [2750], 'imaged': [2752], 'followed': [2763, 4052], '3-min': [2766], 'drug': [2767, 2811], 'treatment': [2768], 'wash': [2772], 'imaged/bleached': [2776], 'second': [2778], 'Drug': [2780], 'concentrations': [2781], 'were:': [2782], '90': [2786], 'TTX.': [2800], 'unpaired': [2802], 'recordings,': [2803], '3': [2808, 4361], 'solutions,': [2812], 'min,': [2816], 'imaged.': [2818], 'Although': [2819, 3989], 'likely': [2823], 'change': [2825, 2862], 'endocyotsis/exocyotsis': [2827], 'rate': [2828], 'AMPARs,': [2830], 'note': [2835], 'issue': [2842], 'analysis': [2845, 3097, 3100], 'kinetics': [2849], 'independent': [2851], 'baseline': [2854], 'levels.': [2855], 'Further,': [2856], 'did': [2858, 3616], 'detect': [2860], 'control': [2867, 4300], 'unbleached': [2871], 'Fluorescence': [2873, 3046, 3074], 'collected': [2875], '63×': [2878], 'oil': [2879], 'objective': [2880], '(N.A.': [2881], '1.4)': [2883], '488': [2886], 'laser': [2888, 2894], 'light': [2889], 'excitation.': [2891], 'excitation': [2895], '10%': [2904], '1%': [2911], 'imaging.': [2914], 'Recovery': [2915], 'curves': [2916, 2979, 3000], 'fitted': [2918, 2963, 3077, 4276], 'Diffusion': [2945, 4064], 'coefficients': [2946], 'area4τ(Eq.': [2953], '3)': [2954], 'curves.': [2965], 'accurately': [2967], 'constructed': [2975], 'fluorescence/membrane': [2976], 'calibration': [2978, 2999], '3.': [2986], 'essence': [2988], 'generated': [2998], 'relating': [3001], 'total': [3003, 3330, 3610, 3697, 3733], 'area.': [3010], 'user-defined': [3015], 'selected': [3019], 'vicinity': [3022], 'isolated': [3025], 'spine,': [3027], 'maintained': [3031, 3205], '(after': [3032], 'basal': [3034], 'iterations)': [3035], 'experiment.': [3045, 3841], 'ImageJ': [3051, 3089], 'software': [3052], 'measuring': [3055], 'equivalent': [3069], 'distance': [3070], 'shaft.': [3073, 3681, 3798], 'monoexponential': [3080], 'decay': [3081], 'QtiPlot': [3083, 3122], 'Files': [3085], 'converted': [3087], '(National': [3090], 'Institutes': [3091], 'Health).': [3093], 'Image': [3094], 'statistical': [3096], '(Kruskal-Wallis': [3098], 'one-way': [3099], 'variance': [3102], 'multiple': [3104, 3638], 'conditions;': [3106], 'post': [3107], 'hoc': [3108], 'rank': [3109], 'sum': [3110], 'test)': [3111], 'software,': [3116], 'graphs': [3118], 'Exocytosis': [3124], 'Occurs': [3127], 'Dendritic': [3130], 'Shaft—Super-ecliptic': [3131], 'pH-sensitive': [3135], 'derivative': [3136], 'excited': [3144], 'low': [3146, 3207], 'pH,': [3147], 'so': [3148], 'emits': [3150], 'no': [3151, 3914, 4388], 'resistant': [3156], 'acidic': [3160, 3408], 'conditions': [3161], '(26Sankaranarayanan': [3162], 'Angelis': [3165], 'Rothman': [3167], 'J.E.': [3168], 'Ryan': [3169], '2000;': [3173], '79:': [3174], '2199-2208Abstract': [3175], '(441)': [3183], 'stages': [3189], 'secretory': [3192], 'pathway,': [3193], 'domains': [3195], 'destined': [3199], 'environment.': [3209], 'SEP': [3211, 3235, 3404], 'fused': [3212], 'terminus': [3217], 'useful': [3225], 'tool': [3226], 'monitoring': [3228], 'exposed': [3238], '(23Ashby': [3245], '25Ashby': [3269], 'When': [3289], 'expressed': [3290], 'neurons,': [3295], 'fluorophore-tagged': [3296], 'subunits': [3298], '(27Perestenko': [3299], 'P.V.': [3300], '278:': [3307], '43525-43532Abstract': [3308], '(40)': [3316], 'Scholar)': [3318, 4169], 'traffic': [3319], 'participate': [3323], 'without': [3327], 'changing': [3328], '(28Shi': [3335], 'Hayashi': [3337], 'Malinow': [3341], 'Cell.': [3343], '105:': [3345], '331-343Abstract': [3346], '(896)': [3354], 'virally': [3358], 'dispersed': [3360], 'hippocampal': [3361], 'expressing': [3363], 'SEP-GluR2,': [3364, 3433], 'photobleached': [3366, 3388, 3702, 3724, 3832], 'defined': [3371], '(FRAP);': [3375], 'then,': [3376], 'avoid': [3378], 'due': [3380], 'diffusion,': [3383], 'repetitively': [3389], '(FLIP,': [3390], '1a).': [3392], 'Importantly,': [3393], 'bleach': [3398], 'intracellular,': [3399, 3893], 'non-fluorescent': [3400], 'localized': [3406], 'trafficking': [3409, 3496], 'vesicles': [3410, 3510], 'intracellular': [3430, 3447, 3495, 3951, 3971], 'visualized': [3437], 'brief': [3440, 3871], 'exposure': [3441, 3872], 'NH4Cl,': [3443, 3874], 'reversibly': [3445], 'collapses': [3446], 'gradients': [3449], '(NH4Cl,': [3450], '1b).': [3452], 'attributed': [3469], 'interest.': [3476], 'There': [3477], 'sources': [3481], 'non-photobleached': [3484], 'exocytosed': [3486, 3602], 'membrane:': [3489], 'supplied': [3493, 3666], 'insertion': [3500, 3523, 3688, 3740, 4047], 'recycled': [3505], 'inside': [3511], 'Consistent': [3516, 3799], 'recent': [3519], 'report': [3520], 'showing': [3521], 'GluR1': [3525], 'published': [3553], 'while': [3554], 'work': [3556], 'progress,': [3559], 'observed': [3561, 3687, 3727], 'never': [3572], 'detected': [3573], '1b,': [3581], 'R1': [3582], 'S1),': [3584], 'indicating': [3585, 3739, 3780], 'had': [3589, 3600, 3686, 3760], '63%': [3607], 'illustrated': [3622], 'individual': [3625], 'example': [3626], 'R2': [3627], '1,': [3631, 3776, 3900, 3919], 'b': [3634, 3920], '(pooled': [3635], 'plotted': [3641], '1d).': [3644], 'suggests': [3646], 'specific': [3652], 'locations': [3653], '"hot': [3655], 'spots"': [3656], 'GluR2-containing': [3669, 4042], 'confirm': [3683], 'rather': [3689], 'redistribution': [3691], 'clustering,': [3693], 'protocol.': [3713], 'Entirely': [3714], 'consistent': [3715, 4350], 'region,': [3725], 'significant': [3729, 3854, 3915], 'points,': [3738], '(Fig.': [3751, 3899, 3918, 4237, 4316, 4344], '1c).': [3752], 'Spines': [3753], 'subjected': [3763], 'lost': [3766], 'S2': [3773, 3823], 'b),': [3779], 'there': [3782, 3851], 'receptor': [3792], 'content': [3793], 'previous': [3802], 'exchanged': [3824], 'nearly': [3825], 'its': [3828], 'ones': [3833], '6-min': [3836], 'frame': [3838], 'cumulative': [3843], '1d': [3848], 'demonstrate': [3849], 'dramatic': [3856], 'calibrated': [3868], 'amplitude': [3877], '(ΔFLIP)': [3885], 'correlated': [3887], 'NH4Cl-sensitive': [3894, 3916], '(ΔNH4Cl)': [3895], 'e': [3901], 'f).': [3903], 'Acidic': [3904], 'quenching': [3905], 'effectively': [3906], 'removed': [3907], 'd;': [3922], 'see': [3923, 3985, 4171, 4295], 'Ref.': [3925, 4364], '16Ashby': [3926, 4365], 'negligible': [3957], 'population,': [3962], 'ruling': [3963], 'possibility': [3966, 3997], 'reservoir': [3969], 'stored': [3973], 'supply': [3978], '(also': [3984, 4170], '4).': [3988], 'certainly': [3991], 'recycling': [4000], 'support': [4033], 'mechanism': [4035], 'head.': [4059, 4465, 4488], 'Topology': [4061], 'Limits': [4062], 'Lateral': [4063], 'Membrane': [4066], 'Proteins—Dendritic': [4067], 'restrict': [4069], 'ions,': [4072], 'small': [4073], 'soluble': [4074], '(3Nimchinsky': [4076], '17Holcman': [4114], 'remains': [4135], 'unclear': [4136], 'modeled': [4149], 'nonplanar': [4151], 'membranes': [4152], '(29Aizenbud': [4153], 'B.M.': [4154], 'Gershon': [4155], 'N.D.': [4156], '1982;': [4159], '38:': [4160], '287-293Abstract': [4161], '(52)': [4167], 'endoplasmic': [4179], 'reticulum': [4180], 'network': [4181], '(30Sbalzarini': [4182], 'I.F.': [4183], 'Hayer': [4184], 'Helenius': [4186], 'Koumoutsakos': [4188], '90:': [4193], '878-885Abstract': [4194], '(80)': [4202], 'investigate': [4206], 'this,': [4207], 'preformed': [4209], 'silico': [4211, 4386], 'three-dimensional': [4217], 'walks': [4219], 'outside': [4222], 'spine)': [4229], 'allowed': [4231], 'freely': [4234], '2,': [4238], 'b).': [4241], 'model': [4244], 'computer-based': [4249], 'radius': [4262, 4267, 4477, 4481], 'adjusted.': [4270], 'curves,': [4278], 'called': [4279], 'efficient': [4281, 4307, 4327], '(Deff),': [4284], '(Dth;': [4294], '"Experimental': [4296], 'Procedures").': [4297], 'areas,': [4304], 'value': [4315], '2c,': [4317], 'median': [4318], 'log(Deff/Dth)': [4320], '-0.042).': [4322], 'mushroom-shaped': [4324], 'smaller': [4332, 4336], '(10-1000-fold,': [4333], '30': [4334], 'times': [4335], 'medians)': [4338], '2c).': [4345], 'entirely': [4349], 'anchoring': [4389], 'subdomain': [4391], 'confinements': [4392], 'imposed,': [4394], 'anomalous': [4404, 4432], 'Entry': [4406], 'exit': [4409], 'do': [4414], 'comparable': [4418], 'probability': [4419], 'propose': [4427], 'imbalance': [4430], 'produces': [4431], 'attribute': [4435], 'narrower': [4453], 'more': [4457], 'impedes': [4459], 'entry': [4461], 'Furthermore,': [4466], 'once': [4467], 'ratio': [4473], 'prevents': [4482], 'short-time': [4491], 'move': [4493], 'freely,': [4494], 'longer': [4497], 'periods': [4498]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2100070396', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 4}, {'year': 2017, 'cited_by_count': 3}, {'year': 2016, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 5}, {'year': 2014, 'cited_by_count': 9}, {'year': 2013, 'cited_by_count': 7}, {'year': 2012, 'cited_by_count': 8}], 'updated_date': '2025-01-07T08:52:07.892030', 'created_date': '2016-06-24'}
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