Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2099505076', 'doi': 'https://doi.org/10.1093/jac/dks080', 'title': 'Mutations in the protease gene associated with virological failure to lopinavir/ritonavir-containing regimens', 'display_name': 'Mutations in the protease gene associated with virological failure to lopinavir/ritonavir-containing regimens', 'publication_year': 2012, 'publication_date': '2012-03-19', 'ids': {'openalex': 'https://openalex.org/W2099505076', 'doi': 'https://doi.org/10.1093/jac/dks080', 'mag': '2099505076', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/22431669'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1093/jac/dks080', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S124275759', 'display_name': 'Journal of Antimicrobial Chemotherapy', 'issn_l': '0305-7453', 'issn': ['0305-7453', '1460-2091'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5102185918', 'display_name': 'José Ramón Santos', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I123044942', 'display_name': 'Universitat Autònoma de Barcelona', 'ror': 'https://ror.org/052g8jq94', 'country_code': 'ES', 'type': 'education', 'lineage': ['https://openalex.org/I123044942']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'J. R. Santos', 'raw_affiliation_strings': ['Lluita contra la SIDA Foundation, Hospital Universitari Germans Trias i Pujol, Universitat Autònoma de Barcelona, Badalona, Barcelona, Spain'], 'affiliations': [{'raw_affiliation_string': 'Lluita contra la SIDA Foundation, Hospital Universitari Germans Trias i Pujol, Universitat Autònoma de Barcelona, Badalona, Barcelona, Spain', 'institution_ids': ['https://openalex.org/I123044942']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5029931096', 'display_name': 'Josep M. Llibre', 'orcid': 'https://orcid.org/0000-0002-7158-6753'}, 'institutions': [{'id': 'https://openalex.org/I123044942', 'display_name': 'Universitat Autònoma de Barcelona', 'ror': 'https://ror.org/052g8jq94', 'country_code': 'ES', 'type': 'education', 'lineage': ['https://openalex.org/I123044942']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'J. M. Llibre', 'raw_affiliation_strings': ['Lluita contra la SIDA Foundation, Hospital Universitari Germans Trias i Pujol, Universitat Autònoma de Barcelona, Badalona, Barcelona, Spain'], 'affiliations': [{'raw_affiliation_string': 'Lluita contra la SIDA Foundation, Hospital Universitari Germans Trias i Pujol, Universitat Autònoma de Barcelona, Badalona, Barcelona, Spain', 'institution_ids': ['https://openalex.org/I123044942']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5043509211', 'display_name': 'Arkaitz Imaz', 'orcid': 'https://orcid.org/0000-0001-8411-1952'}, 'institutions': [{'id': 'https://openalex.org/I2802050225', 'display_name': 'Bellvitge University Hospital', 'ror': 'https://ror.org/00epner96', 'country_code': 'ES', 'type': 'healthcare', 'lineage': ['https://openalex.org/I157913058', 'https://openalex.org/I2802050225', 'https://openalex.org/I4210153292']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'A. Imaz', 'raw_affiliation_strings': ["HIV Unit, Service of Infectious Diseases, Hospital Universitari de Bellvitge, L'Hospitalet de Llobregat, Barcelona, Spain"], 'affiliations': [{'raw_affiliation_string': "HIV Unit, Service of Infectious Diseases, Hospital Universitari de Bellvitge, L'Hospitalet de Llobregat, Barcelona, Spain", 'institution_ids': ['https://openalex.org/I2802050225']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5072944678', 'display_name': 'Peré Domingo', 'orcid': 'https://orcid.org/0000-0003-1138-5770'}, 'institutions': [{'id': 'https://openalex.org/I123044942', 'display_name': 'Universitat Autònoma de Barcelona', 'ror': 'https://ror.org/052g8jq94', 'country_code': 'ES', 'type': 'education', 'lineage': ['https://openalex.org/I123044942']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'P. Domingo', 'raw_affiliation_strings': ['Infectious Diseases Unit, Hospital de la Santa Creu I Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain'], 'affiliations': [{'raw_affiliation_string': 'Infectious Diseases Unit, Hospital de la Santa Creu I Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain', 'institution_ids': ['https://openalex.org/I123044942']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5107863613', 'display_name': 'José Antonio Iribarren', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210100188', 'display_name': 'Biogipuzkoa Health Research Institute', 'ror': 'https://ror.org/01a2wsa50', 'country_code': 'ES', 'type': 'facility', 'lineage': ['https://openalex.org/I4210100188']}, {'id': 'https://openalex.org/I4210125364', 'display_name': 'Osakidetza', 'ror': 'https://ror.org/02g7qcb42', 'country_code': 'ES', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210125364']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'J. A. Iribarren', 'raw_affiliation_strings': ['Service of Infectious Diseases, Hospital Donostia, Osakidetza, San Sebastián, Spain'], 'affiliations': [{'raw_affiliation_string': 'Service of Infectious Diseases, Hospital Donostia, Osakidetza, San Sebastián, Spain', 'institution_ids': ['https://openalex.org/I4210100188', 'https://openalex.org/I4210125364']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5107963472', 'display_name': 'Ana Mariño', 'orcid': 'https://orcid.org/0000-0002-3150-0118'}, 'institutions': [{'id': 'https://openalex.org/I4210166877', 'display_name': 'Complejo Hospitalario Universitario de Ferrol', 'ror': 'https://ror.org/03xj2sn10', 'country_code': 'ES', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210158352', 'https://openalex.org/I4210166877']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'A. Marino', 'raw_affiliation_strings': ['Infectious Diseases Unit, Hospital Arquitecto Marcide, Ferrol, Spain'], 'affiliations': [{'raw_affiliation_string': 'Infectious Diseases Unit, Hospital Arquitecto Marcide, Ferrol, Spain', 'institution_ids': ['https://openalex.org/I4210166877']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5015434274', 'display_name': 'Celia Miralles', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210158468', 'display_name': 'Hospital Xeral Calde', 'ror': 'https://ror.org/00zbht122', 'country_code': 'ES', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210158468']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'C. Miralles', 'raw_affiliation_strings': ['HIV Unit, Hospital Xeral Cies, Vigo, Spain'], 'affiliations': [{'raw_affiliation_string': 'HIV Unit, Hospital Xeral Cies, Vigo, Spain', 'institution_ids': ['https://openalex.org/I4210158468']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5110216254', 'display_name': 'Marı́a José Galindo', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210094406', 'display_name': 'Hospital Clínico Universitario de Valencia', 'ror': 'https://ror.org/00hpnj894', 'country_code': 'ES', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210094406']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'M. J. Galindo', 'raw_affiliation_strings': ['Unit of Infectious Diseases, Hospital Clínico Universitario, Valencia, Spain'], 'affiliations': [{'raw_affiliation_string': 'Unit of Infectious Diseases, Hospital Clínico Universitario, Valencia, Spain', 'institution_ids': ['https://openalex.org/I4210094406']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5112963957', 'display_name': 'A Ornelas', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I42134832', 'display_name': 'Barcelona School of Economics', 'ror': 'https://ror.org/02k09n368', 'country_code': 'ES', 'type': 'education', 'lineage': ['https://openalex.org/I42134832']}, {'id': 'https://openalex.org/I71999127', 'display_name': 'Universitat de Barcelona', 'ror': 'https://ror.org/021018s57', 'country_code': 'ES', 'type': 'education', 'lineage': ['https://openalex.org/I71999127']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'A. Ornelas', 'raw_affiliation_strings': ['Department of Econometrics, Statistics and Spanish Economy, University of Barcelona, Barcelona, Spain'], 'affiliations': [{'raw_affiliation_string': 'Department of Econometrics, Statistics and Spanish Economy, University of Barcelona, Barcelona, Spain', 'institution_ids': ['https://openalex.org/I42134832', 'https://openalex.org/I71999127']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100732145', 'display_name': 'Santiago Moreno', 'orcid': 'https://orcid.org/0000-0002-2843-1094'}, 'institutions': [{'id': 'https://openalex.org/I4210161852', 'display_name': 'Hospital Universitario Ramón y Cajal', 'ror': 'https://ror.org/050eq1942', 'country_code': 'ES', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210139293', 'https://openalex.org/I4210161852']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'S. Moreno', 'raw_affiliation_strings': ['Service of Infectious Diseases, Hospital Ramón y Cajal, Madrid, Spain'], 'affiliations': [{'raw_affiliation_string': 'Service of Infectious Diseases, Hospital Ramón y Cajal, Madrid, Spain', 'institution_ids': ['https://openalex.org/I4210161852']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5110224117', 'display_name': 'Jonathan Schapiro', 'orcid': None}, 'institutions': [], 'countries': ['IL'], 'is_corresponding': False, 'raw_author_name': 'J. M. Schapiro', 'raw_affiliation_strings': ['National Haemophilia Centre, Tel Aviv, Israel'], 'affiliations': [{'raw_affiliation_string': 'National Haemophilia Centre, Tel Aviv, Israel', 'institution_ids': []}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5024863386', 'display_name': 'B. Clotet', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I123044942', 'display_name': 'Universitat Autònoma de Barcelona', 'ror': 'https://ror.org/052g8jq94', 'country_code': 'ES', 'type': 'education', 'lineage': ['https://openalex.org/I123044942']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'B. Clotet', 'raw_affiliation_strings': ['Lluita contra la SIDA Foundation, Hospital Universitari Germans Trias i Pujol, Universitat Autònoma de Barcelona, Badalona, Barcelona, Spain'], 'affiliations': [{'raw_affiliation_string': 'Lluita contra la SIDA Foundation, Hospital Universitari Germans Trias i Pujol, Universitat Autònoma de Barcelona, Badalona, Barcelona, Spain', 'institution_ids': ['https://openalex.org/I123044942']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 10, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 2627, 'currency': 'GBP', 'value_usd': 3222, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 0.331, 'has_fulltext': False, 'cited_by_count': 6, 'citation_normalized_percentile': {'value': 0.573419, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 81, 'max': 82}, 'biblio': {'volume': '67', 'issue': '6', 'first_page': '1462', 'last_page': '1469'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10526', 'display_name': 'HIV/AIDS drug development and treatment', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2725', 'display_name': 'Infectious Diseases'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10526', 'display_name': 'HIV/AIDS drug development and treatment', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2725', 'display_name': 'Infectious Diseases'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12369', 'display_name': 'Pneumocystis jirovecii pneumonia detection and treatment', 'score': 0.9991, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10151', 'display_name': 'Hepatitis C virus research', 'score': 0.9982, 'subfield': {'id': 'https://openalex.org/subfields/2721', 'display_name': 'Hepatology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/lopinavir', 'display_name': 'Lopinavir', 'score': 0.9863802}, {'id': 'https://openalex.org/keywords/ritonavir', 'display_name': 'Ritonavir', 'score': 0.954723}, {'id': 'https://openalex.org/keywords/lopinavir/ritonavir', 'display_name': 'Lopinavir/ritonavir', 'score': 0.7776201}, {'id': 'https://openalex.org/keywords/protease-inhibitor', 'display_name': 'Protease inhibitor (pharmacology)', 'score': 0.4180462}], 'concepts': [{'id': 'https://openalex.org/C2777182164', 'wikidata': 'https://www.wikidata.org/wiki/Q422585', 'display_name': 'Lopinavir', 'level': 5, 'score': 0.9863802}, {'id': 'https://openalex.org/C2779298103', 'wikidata': 'https://www.wikidata.org/wiki/Q422618', 'display_name': 'Ritonavir', 'level': 5, 'score': 0.954723}, {'id': 'https://openalex.org/C2781392899', 'wikidata': 'https://www.wikidata.org/wiki/Q422618', 'display_name': 'Lopinavir/ritonavir', 'level': 5, 'score': 0.7776201}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.48482266}, {'id': 'https://openalex.org/C159047783', 'wikidata': 'https://www.wikidata.org/wiki/Q7215', 'display_name': 'Virology', 'level': 1, 'score': 0.44534767}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.43418786}, {'id': 'https://openalex.org/C2781143361', 'wikidata': 'https://www.wikidata.org/wiki/Q55761529', 'display_name': 'Protease inhibitor (pharmacology)', 'level': 5, 'score': 0.4180462}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.41017774}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.34628782}, {'id': 'https://openalex.org/C3013748606', 'wikidata': 'https://www.wikidata.org/wiki/Q15787', 'display_name': 'Human immunodeficiency virus (HIV)', 'level': 2, 'score': 0.19890755}, {'id': 'https://openalex.org/C142462285', 'wikidata': 'https://www.wikidata.org/wiki/Q2528140', 'display_name': 'Viral load', 'level': 3, 'score': 0.18980777}, {'id': 'https://openalex.org/C2993143319', 'wikidata': 'https://www.wikidata.org/wiki/Q583050', 'display_name': 'Antiretroviral therapy', 'level': 4, 'score': 0.064156145}], 'mesh': [{'descriptor_ui': 'D019380', 'descriptor_name': 'Anti-HIV Agents', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': True}, {'descriptor_ui': 'D006678', 'descriptor_name': 'HIV', 'qualifier_ui': 'Q000302', 'qualifier_name': 'isolation & purification', 'is_major_topic': True}, {'descriptor_ui': 'D015658', 'descriptor_name': 'HIV Infections', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D016333', 'descriptor_name': 'HIV Protease', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D061466', 'descriptor_name': 'Lopinavir', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': True}, {'descriptor_ui': 'D020125', 'descriptor_name': 'Mutation, Missense', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D019438', 'descriptor_name': 'Ritonavir', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': True}, {'descriptor_ui': 'D000328', 'descriptor_name': 'Adult', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019943', 'descriptor_name': 'Amino Acid Substitution', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019380', 'descriptor_name': 'Anti-HIV Agents', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D019380', 'descriptor_name': 'Anti-HIV Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015331', 'descriptor_name': 'Cohort Studies', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006678', 'descriptor_name': 'HIV', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D006678', 'descriptor_name': 'HIV', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015658', 'descriptor_name': 'HIV Infections', 'qualifier_ui': 'Q000821', 'qualifier_name': 'virology', 'is_major_topic': False}, {'descriptor_ui': 'D015658', 'descriptor_name': 'HIV Infections', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016333', 'descriptor_name': 'HIV Protease', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D061466', 'descriptor_name': 'Lopinavir', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D061466', 'descriptor_name': 'Lopinavir', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012189', 'descriptor_name': 'Retrospective Studies', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019438', 'descriptor_name': 'Ritonavir', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D019438', 'descriptor_name': 'Ritonavir', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017211', 'descriptor_name': 'Treatment Failure', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014481', 'descriptor_name': 'United States', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1093/jac/dks080', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S124275759', 'display_name': 'Journal of Antimicrobial Chemotherapy', 'issn_l': '0305-7453', 'issn': ['0305-7453', '1460-2091'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/22431669', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 23, 'referenced_works': ['https://openalex.org/W1524252975', 'https://openalex.org/W1996411944', 'https://openalex.org/W2013129339', 'https://openalex.org/W2049969210', 'https://openalex.org/W2052536101', 'https://openalex.org/W2052991207', 'https://openalex.org/W2056242657', 'https://openalex.org/W2057090392', 'https://openalex.org/W2076339980', 'https://openalex.org/W2088221871', 'https://openalex.org/W2093920807', 'https://openalex.org/W2098570626', 'https://openalex.org/W2109350540', 'https://openalex.org/W2116639849', 'https://openalex.org/W2120536879', 'https://openalex.org/W2139772076', 'https://openalex.org/W2141077880', 'https://openalex.org/W2144984387', 'https://openalex.org/W2154669635', 'https://openalex.org/W2171236519', 'https://openalex.org/W25726050', 'https://openalex.org/W2916981229', 'https://openalex.org/W4236479494'], 'related_works': ['https://openalex.org/W748358169', 'https://openalex.org/W3035595114', 'https://openalex.org/W2407014618', 'https://openalex.org/W2166306740', 'https://openalex.org/W2162955592', 'https://openalex.org/W2161967914', 'https://openalex.org/W2106855395', 'https://openalex.org/W2106522682', 'https://openalex.org/W2067601295', 'https://openalex.org/W2055153247'], 'abstract_inverted_index': {'To': [0], 'assess': [1], 'the': [2, 118, 154, 173], 'most': [3, 119], 'frequent': [4], 'resistance-associated': [5], 'mutations': [6, 191], '(RAMs)': [7], 'to': [8, 147, 169, 234], 'lopinavir/ritonavir': [9, 37, 54, 105, 128, 187, 241], 'in': [10, 16, 102, 121, 208], 'a': [11], 'cohort': [12], 'of': [13, 156, 175, 210, 227], 'patients': [14, 103, 182], 'attended': [15], 'daily': [17], 'practice.We': [18], 'retrospectively': [19], 'identified': [20], '195': [21], 'multitreated': [22, 181], 'subjects': [23], 'with': [24, 94, 104, 142, 153, 183, 240], 'virological': [25], 'failure.': [26, 56, 106, 242], 'Patients': [27], 'were': [28, 52, 59, 74, 98, 117, 139, 206, 237], 'classified': [29], 'as': [30], 'follows:': [31], '(i)': [32], '71': [33], '(36.4%)': [34], 'never': [35], 'received': [36], '(lopinavir/ritonavir': [38], 'naive);': [39], '(ii)': [40], '75': [41], '(38.5%)': [42], 'had': [43], 'previously': [44], 'failed': [45], 'on': [46, 53], 'lopinavir/ritonavir;': [47], 'and': [48, 70, 91, 115, 137, 172, 179, 204, 230], '(iii)': [49], '49': [50], '(25.1%)': [51], 'at': [55, 194], 'RAM': [57], 'patterns': [58], 'assessed.': [60], 'Medians,': [61], 'IQRs,': [62], 'percentages,': [63], 'Kruskal-Wallis,': [64], 'χ(2)': [65], 'or': [66, 144, 185], "Fisher's": [67], 'exact': [68], 'test,': [69], 'multinomial': [71], 'logistic': [72], 'regression': [73], 'used': [75], 'whenever': [76], 'appropriate.L10I/F,': [77], 'K20R,': [78], 'L24I,': [79], 'L33F,': [80, 177], 'M36I,': [81, 108, 199], 'M46I/L,': [82], 'I47V,': [83], 'G48V,': [84], 'F53L,': [85], 'I54V,': [86, 110, 200], 'A71V,': [87, 112, 202], 'G73S,': [88], 'V82A,': [89, 113], 'I84V': [90, 114], 'L90M': [92, 116, 205], '(all': [93], 'P': [95], '≤': [96], '0.037)': [97], 'protease': [99, 157, 170, 190, 228, 235], 'RAMs': [100, 126, 158, 229], 'overexpressed': [101], 'L10I,': [107, 198], 'M46I,': [109], 'L63P,': [111, 201], 'common': [120], 'lopinavir/ritonavir-naive': [122], 'patients.': [123], 'Other': [124], 'IAS-USA': [125], 'for': [127], '(L10R/V,': [129], 'K20M,': [130], 'V32I,': [131], 'I47A,': [132], 'I50V,': [133], 'I54L/A/M/T/S,': [134], 'A71T,': [135], 'L76V': [136], 'V82F/T/S)': [138], 'not': [140, 223], 'associated': [141, 152, 239], 'previous': [143, 184], 'current': [145, 186], 'failure': [146, 150], 'lopinavir/ritonavir.': [148], 'Lopinavir/ritonavir': [149], 'was': [151], 'number': [155, 226], '(OR': [159], '=': [160, 164], '1.146,': [161], '95%': [162], 'CI': [163], '1.287,': [165], '1.626),': [166], 'higher': [167, 231], 'exposure': [168], 'inhibitors,': [171], 'presence': [174, 214], 'E44D,': [176], 'I54V': [178], 'I84V.In': [180], 'failure,': [188], 'some': [189], 'are': [192, 222], 'selected': [193], 'significantly': [195, 238], 'greater': [196], 'rates.': [197], 'V82A': [203], 'found': [207], '>50%': [209], 'cases.': [211], 'Thus,': [212], 'their': [213], 'should': [215], 'be': [216], 'expected': [217], 'when': [218], 'genotypic': [219], 'testing': [220], 'results': [221], 'available.': [224], 'The': [225], 'prior': [232], 'exposures': [233], 'inhibitors': [236]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2099505076', 'counts_by_year': [{'year': 2021, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 2}, {'year': 2014, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 1}], 'updated_date': '2024-12-17T19:09:54.470990', 'created_date': '2016-06-24'}