A Comparative Study on the Hydroperoxide and Thiol Specificity of the Glutathione Peroxidase Family and Selenoprotein P

Name: Work Video:
Duration: 3 min 30 s
Gen Takebe; Junko Yarimizu; Yoshiro Saito; Takaaki Hayashi; Hajime Nakamura; Junji Yodoi; Shigeharu Nagasawa; Kazuhiko Takahashi
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3062, 3119, 3184, 3341, 3365, 3386, 3506, 4493], 'of': [5, 18, 75, 89, 92, 108, 180, 193, 250, 264, 267, 283, 409, 444, 482, 514, 522, 632, 693, 725, 736, 782, 888, 953, 963, 973, 1013, 1022, 1049, 1053, 1067, 1081, 1102, 1116, 1122, 1139, 1149, 1319, 1477, 1562, 1608, 1613, 1620, 1668, 1675, 1680, 1710, 1718, 1737, 1753, 1783, 1825, 1836, 1853, 1901, 1959, 2020, 2089, 2114, 2134, 2165, 2206, 2224, 2290, 2349, 2359, 2367, 2372, 2404, 2605, 2622, 2691, 2698, 2702, 2708, 2713, 2716, 2724, 2878, 2892, 2909, 2913, 2940, 2954, 2971, 2975, 3025, 3030, 3050, 3064, 3080, 3107, 3121, 3137, 3174, 3185, 3225, 3232, 3242, 3247, 3263, 3270, 3278, 3304, 3308, 3313, 3337, 3343, 3351, 3367, 3460, 3490, 3495, 3498, 3507, 3532, 3564, 3641, 3676, 3742, 3746, 3772, 3817, 3821, 3847, 3870, 3881, 3908, 3943, 3973, 4003, 4047, 4052, 4104, 4121, 4137, 4151, 4176, 4268, 4277, 4307, 4315, 4414, 4437, 4441, 4453, 4459, 4523, 4553, 4591, 4636, 4669, 4679, 4725, 4730, 4734, 4780, 4792, 4863, 4915, 4920, 4976, 5000, 5007, 5058, 5074, 5082, 5111, 5124, 5181], 'hydrogen': [6, 181, 958, 1159], 'peroxide': [7, 86, 127, 156, 182, 261, 302, 331, 959, 1023, 1124, 1160, 1711, 2225, 2411, 2915, 2977, 3259, 3300, 3867, 4331], 'and': [8, 13, 35, 61, 103, 107, 120, 128, 139, 157, 160, 171, 183, 188, 210, 236, 278, 282, 295, 303, 314, 332, 335, 346, 455, 463, 469, 677, 729, 771, 780, 854, 861, 966, 969, 1030, 1044, 1078, 1108, 1113, 1134, 1158, 1171, 1210, 1224, 1276, 1354, 1512, 1518, 1528, 1538, 1647, 1665, 1723, 1747, 1771, 1785, 1905, 1989, 2023, 2030, 2102, 2126, 2138, 2140, 2195, 2229, 2247, 2258, 2286, 2316, 2341, 2408, 2426, 2431, 2436, 2454, 2459, 2464, 2482, 2487, 2492, 2503, 2539, 2544, 2549, 2567, 2633, 2701, 2727, 2748, 2755, 2765, 2769, 2781, 2803, 2825, 2889, 2951, 3034, 3052, 3059, 3066, 3109, 3116, 3123, 3244, 3292, 3315, 3347, 3357, 3381, 3395, 3409, 3478, 3554, 3568, 3631, 3684, 3721, 3796, 3878, 3880, 3914, 3960, 3976, 3986, 4025, 4033, 4124, 4144, 4168, 4246, 4280, 4344, 4417, 4447, 4497, 4549, 4567, 4597, 4672, 4683, 4704, 4737, 4741, 4750, 4762, 4827, 4912, 4965, 5113, 5119, 5131, 5139, 5141, 5153, 5156, 5167, 5185, 5193, 5208, 5217], 'organic': [9, 184], 'hydroperoxide': [10, 100, 185, 275, 369, 457, 823, 980, 1154, 2094, 2623, 2788, 4978], 'by': [11, 186, 545, 1213, 1230, 1242, 1252, 1287, 1604, 1624, 1707, 1764, 1903, 1953, 2093, 2111, 2211, 2513, 2522, 2577, 2586, 2596, 2720, 2800, 3056, 3070, 3113, 3127, 3187, 3236, 3412, 3502, 3648, 3657, 3748, 3759, 3823, 3834, 4341, 4832], 'glutathione': [12, 46, 94, 97, 101, 105, 187, 221, 269, 272, 276, 280, 358, 365, 370, 374, 964, 2826, 3004, 4390, 4401], 'functions': [14, 189, 903], 'in': [15, 26, 31, 190, 201, 206, 406, 605, 637, 641, 733, 759, 777, 824, 859, 1486, 1497, 1508, 1524, 1540, 1551, 1565, 1610, 1671, 1964, 2017, 2123, 2162, 2283, 2364, 2556, 2683, 2740, 2922, 3088, 3418, 3575, 3601, 3638, 3783, 3939, 3951, 4044, 4110, 4252, 4645, 4789, 4884, 4973, 4979, 5033, 5039, 5055, 5064, 5121, 5135, 5145], 'protection': [17, 192, 781, 5123], 'cells': [19, 194, 1223, 1332, 4922, 5086, 5126], 'against': [20, 123, 195, 298, 524, 785, 1141, 1535, 2302, 2626, 3523, 3593, 5187], 'oxidative': [21, 167, 196, 342, 786, 2696, 2871, 2933, 3476, 5053, 5128, 5164], 'damage.': [22, 197], 'exists': [25, 200], 'several': [27, 202, 894], 'forms': [28, 203, 1101, 2133, 4175], 'that': [29, 41, 141, 204, 216, 316, 478, 811, 901, 950, 967, 1009, 1061, 2358, 2773, 2779, 2806, 3081, 3138, 3255, 3602, 3655, 3670, 3957, 4008, 4127, 4258, 4348, 4503, 4515, 4564, 4615, 4727, 4742, 4773, 4963, 4997, 5044], 'differ': [30, 205, 3726, 3801, 3990], 'their': [32, 207], 'primary': [33, 208], 'structure': [34, 209], 'localization.': [36, 211], 'We': [37, 133, 212, 308, 808, 1059, 1126, 3265, 5200], 'have': [38, 213, 460, 896, 3929, 4613], 'also': [39, 214, 503, 1794, 2647, 3579, 4218, 4585, 4854, 4943], 'shown': [40, 215, 718, 2122, 2161, 2739, 3082, 3139, 3417, 3452, 3938, 3950], 'selenoprotein': [42, 109, 149, 217, 284, 324, 380, 812, 858], 'P': [43, 110, 218, 285, 813], 'exhibits': [44, 219], 'a': [45, 81, 220, 256, 474, 519, 630, 683, 686, 722, 825, 1019, 1026, 1046, 1350, 1422, 1574, 1642, 1672, 1790, 1822, 1870, 2013, 2097, 2118, 2171, 2182, 2250, 2278, 2557, 2659, 2893, 2923, 2955, 3020, 3078, 3089, 3135, 3148, 3177, 3512, 3535, 3581, 3599, 3784, 3891, 4327, 4382, 4388, 4409, 4474, 4491, 4504, 4526, 4686, 4731, 4776, 4824, 4855, 5071, 5107], 'peroxidase-like': [47, 222], 'activity': [48, 223, 1012, 1748, 1760, 2217, 2289, 2301, 2327, 2348, 2378, 3037, 3074, 3094, 3131, 3214, 3277, 3366, 3972, 4040, 4058, 4088, 4120], '(Saito,': [49, 224], 'Y.,': [50, 56, 225, 231], 'Hayashi,': [51, 226], 'T.,': [52, 227], 'Tanaka,': [53, 228], 'A.,': [54, 229], 'Watanabe,': [55, 230], 'Suzuki,': [57, 232], 'M.,': [58, 233], 'Saito,': [59, 234], 'E.,': [60, 235], 'Takahashi,': [62, 237], 'K.': [63, 238, 558, 613, 841, 920, 935, 997, 1308, 1377, 1388, 1440, 1458, 1592, 1809, 1886, 1925, 3444, 4805], '(1999)': [64, 239], 'J.': [65, 240, 534, 566, 568, 569, 589, 617, 750, 803, 842, 879, 921, 937, 1201, 1309, 1342, 1378, 1452, 1456, 1593, 1810, 1887, 1926, 2066, 2068, 3156, 3163, 4428, 4532, 4539, 4810, 4898], 'Biol.': [66, 241, 436, 535, 843, 869, 922, 940, 1310, 1343, 1379, 1594, 1811, 1888, 1927, 2075, 3164, 4540, 4811, 5099], 'Chem.': [67, 242, 536, 844, 923, 941, 1311, 1344, 1380, 1595, 1812, 1889, 1928, 2076, 2676, 3165, 3438, 3446, 4203, 4541, 4812], '274,': [68, 243], '2866–2871).': [69, 244], 'To': [70, 245, 1779, 1894, 3170, 3856, 3968], 'understand': [71, 246, 1063], 'physiological': [73, 248, 886, 1065, 1147], 'significance': [74, 249, 1066, 1148], 'diversity': [77, 252], 'among': [78, 253, 2309, 2985], 'these': [79, 254, 1117, 2617, 3931, 4009, 4128, 4460, 5038, 5116], 'enzymes,': [80, 255, 2988], 'comparative': [82, 257, 3863], 'study': [83, 258, 3864], 'on': [84, 259, 1573, 2175, 3275, 3339, 3363, 3865, 4023, 4147, 4610, 4984, 5115, 5196], 'substrate': [87, 262, 1024, 1960, 1987, 2305, 2606, 3868, 4506, 4528, 4779, 5152], 'specificity': [88, 138, 263, 313, 1133, 2994, 3869, 4329, 4476, 4612, 4650], 'three': [90, 265, 1099, 1120, 2222, 2645, 3011, 3219, 3872, 4010, 4129, 4373, 4397, 4436, 4471], 'types': [91, 266, 443, 3875], 'ubiquitous': [93, 268, 1100, 3873], '(cellular': [96, 271, 446], 'peroxidase,': [98, 102, 273, 277, 4391], 'phospholipid': [99, 274, 368, 456, 822, 1719, 2787, 4138, 4977], 'extracellular': [104, 279, 373, 452, 607, 852, 4843, 4885, 4981, 5137], 'peroxidase)': [106, 281], 'purified': [111, 286, 1083, 1098, 1251, 1327, 1357, 1398, 1428, 2143, 3883], 'from': [112, 166, 287, 341, 548, 1039, 1084, 1163, 1175, 1180, 1268, 1285, 1328, 1358, 1399, 1429, 1998, 2035, 2144, 2752, 2763, 2774, 2886, 2907, 2948, 2969, 3884, 3897, 3934, 4165, 4220, 4676, 5052, 5127, 5163], 'human': [113, 288, 862, 1106, 1188, 1329, 1359, 1400, 1430, 2145, 2149, 2152, 3885, 3935, 4921, 5213], 'origins': [114, 289, 1041], 'was': [115, 290, 479, 1016, 1037, 1179, 1191, 1239, 1249, 1266, 1283, 1326, 1397, 1427, 1471, 1522, 1533, 1571, 1683, 1693, 1705, 1739, 1749, 1761, 1793, 1828, 1840, 1907, 1950, 2209, 2219, 2293, 2306, 2353, 2511, 2575, 2598, 3038, 3075, 3095, 3132, 3189, 3215, 3318, 3322, 3326, 3329, 3370, 3650, 3666, 3860, 4217, 4787, 4819, 4995, 5002], 'done.': [116, 291], 'The': [117, 292, 885, 1531, 1690, 1735, 1847, 1986, 2025, 2083, 2104, 2204, 2271, 2346, 2560, 2589, 2643, 2722, 2926, 3009, 3212, 3349, 3403, 3504, 3562, 3628, 3643, 3731, 3787, 3806, 4108, 4371, 5080], 'specific': [118, 293, 762, 1011, 1076, 1111, 2347, 4039, 4777], 'activities': [119, 294, 1052, 1077, 1112, 1601, 2497, 2561, 3049, 3063, 3106, 3120, 3342, 3373, 3387], 'kinetic': [121, 296, 1079, 1114, 1137, 2590, 2650, 3404, 3678, 4670, 4677, 4785, 4833], 'parameters': [122, 297, 1080, 1115, 1138], 'two': [124, 299, 2112, 2710, 2880, 2942, 3492, 3774, 3849], 'hydroperoxides': [125, 300, 411, 527, 633, 635, 972, 4139, 4587, 5189], '(hydrogen': [126, 301], 'phosphatidylcholine': [129, 304, 387, 979], 'hydroperoxide)': [130, 305], 'were': [131, 306, 1161, 1174, 1227, 1278, 1318, 1356, 1500, 1602, 1725, 1850, 2005, 2033, 2142, 2498, 2562, 2624, 2750, 2767, 2905, 2967, 3054, 3068, 3111, 3125, 3221, 3376, 3390, 3414, 3558, 3570, 3634, 3946, 3984, 3987, 4163, 4250, 4644], 'determined.': [132, 307, 2919], 'next': [134, 309, 1127, 2990, 3266], 'examined': [135, 310, 1603, 3190, 3267], 'thiol': [137, 158, 312, 333, 1130, 1788, 1897, 2993, 3149, 3178, 3688, 4405, 4527, 4611, 4778, 5154], 'found': [140, 315, 3988, 5144], 'thioredoxin': [142, 317, 1189], 'is': [143, 318, 466, 473, 502, 508, 542, 551, 600, 682, 731, 850, 855, 890, 947, 1071, 2086, 2108, 2520, 2584, 2653, 2790, 2808, 2815, 3144, 3455, 3466, 3480, 3955, 4260, 4350, 4387, 4517, 4617, 4655, 4748, 4775, 4853, 4881, 4923, 4942, 5066], 'preferred': [145, 320], 'electron': [146, 321, 3007, 4369, 4620, 4661], 'donor': [147, 322, 3150, 3179, 4621, 4662], 'for': [148, 323, 1258, 1515, 1544, 1556, 1698, 2274, 2379, 2383, 2505, 2569, 2592, 2655, 2694, 2705, 2730, 2746, 2760, 2822, 2869, 2875, 2902, 2931, 2937, 2964, 3151, 3180, 3378, 3392, 3406, 3474, 3487, 3529, 3664, 3671, 3680, 3719, 3737, 3753, 3794, 3812, 3828, 3978, 3991, 4059, 4063, 4115, 4161, 4215, 4225, 4495, 4642, 4651, 4702, 4746, 5076, 5211], 'P.': [150, 325, 663, 4070], 'These': [151, 326, 3252, 3994, 4960, 5148], 'four': [152, 327, 2167, 2310, 2987, 3280, 3932, 4418], 'enzymes': [153, 328, 1082, 1118, 2311, 2646, 2719, 3012, 3281, 3933, 3945, 4011, 4130, 4374, 4398, 4472, 5149], 'exhibit': [154, 329, 4012, 5150], 'different': [155, 330, 1020, 1027, 1040, 2297, 2634, 4013, 4135, 5151], 'specificities': [159, 334, 3029, 5155], 'collaborate': [161, 336, 5157], 'to': [162, 337, 486, 719, 769, 816, 898, 1062, 1073, 1474, 1685, 1712, 1727, 1830, 2000, 2008, 2095, 2116, 2185, 2280, 2351, 2410, 2638, 2786, 2812, 3077, 3134, 3146, 3234, 3290, 3374, 3388, 3778, 3853, 3989, 3999, 4015, 4041, 4134, 4263, 4330, 4354, 4477, 4489, 4519, 4577, 4622, 4629, 4648, 4663, 4822, 4858, 5047, 5084, 5106, 5158, 5177], 'protect': [163, 338, 5048, 5159], 'biological': [164, 339, 5161], 'molecules': [165, 340, 2113, 5162], 'stress': [168, 343, 5165], 'both': [169, 344, 1713, 2753, 4166, 4595], 'inside': [170, 345, 5166], 'outside': [172, 347, 5168], 'cells.': [174, 349, 4153], 'peroxidases': [351, 4402], '(GPx)': [352], '1The': [353], 'abbreviations': [354], 'used': [355, 3002, 4364], 'are:': [356], 'GPx,': [357], 'peroxidase;': [359, 366, 371, 375], 'GSH,': [360, 1170, 1664, 2237, 3658], 'reduced': [361, 2110, 2334, 3299, 3500, 4738], 'glutathione;': [362], 'cGPx,': [363, 675, 2021, 3876], 'cellular': [364], 'PHGPx,': [367, 2775, 2802, 3877, 3975, 4122, 4256, 4343], 'eGPx,': [372, 2022, 2137, 2801, 3974, 4123, 4342, 4637], 'GIGPx,': [376, 676], 'gastrointestinal': [377, 449, 516], 'GPx;': [378], 'SeP,': [379, 2804, 3181, 3316, 4498], 'P;': [381], 't-Bu-OOH,': [382, 2227], 'tertiary': [383, 4559], 'butyl': [384, 1153], 'hydroperoxide;': [385, 388], 'PC-OOH,': [386, 2230, 3979], 'HPLC,': [389], 'high': [390, 4758, 5108], 'performance': [391], 'liquid': [392, 1260], 'chromatography;': [393], 'TRX,': [394], 'thioredoxin.': [395, 1142], 'containing': [396, 3204], 'selenocysteine': [397, 819, 3909, 4093], 'at': [398, 511, 960, 1025, 1695, 1731, 1741, 1744, 1993, 2243, 2312, 2328, 2337, 2610, 2630, 3023, 3045, 3102, 3260, 3301, 3610, 4094, 4588, 4599, 4752, 4917], 'catalytic': [400], 'center': [401], 'play': [402], 'an': [403, 504, 851, 905, 1732, 3006, 3898, 4273, 4368, 4660, 4842], 'important': [404, 1072], 'role': [405], 'detoxification': [408], 'various': [410, 2612, 5188], '(1Ursini': [412, 4283], 'F.': [413, 698, 740, 982, 1413, 1634, 1940, 1974, 2043, 2072, 4180, 4229, 4284], 'Maiorino': [414, 647, 699, 745, 983, 1408, 1935, 1975, 2044, 4181, 4230, 4285], 'M.': [415, 560, 648, 700, 702, 744, 746, 791, 797, 837, 916, 984, 1304, 1373, 1409, 1588, 1630, 1805, 1882, 1921, 1936, 1976, 2045, 2056, 3154, 4182, 4231, 4286, 4530, 4896], 'Brigelius-Flohe': [416, 2059, 4287, 4806], 'R.': [417, 433, 650, 2060, 4288, 4424, 4807], 'Aumann': [418, 2057, 4289, 4800], 'K.D.': [419, 2058, 4290, 4801], 'Roveri': [420, 747, 2069, 4291], 'A.': [421, 748, 795, 833, 912, 1197, 1300, 1369, 1407, 1584, 1801, 1878, 1917, 1934, 2070, 3162, 4292, 4426, 4538, 4873, 4894, 4907, 4928, 4949, 4953], 'Schomburg': [422, 4293], 'D.': [423, 793, 801, 2062, 4294, 4930], 'Flohe': [424, 751, 2073, 4295, 4808], 'L.': [425, 490, 704, 752, 2074, 2666, 3428, 4193, 4296, 4809, 4871], 'Methods': [426, 1635, 4297, 4874], 'Enzymol.': [427, 1636, 4298, 4875], '1995;': [428, 1865, 2079, 4299, 5026], '252:': [429, 4300], '38-53Google': [430, 4301], 'Scholar,': [431, 575, 874, 927, 993, 1384, 1932, 2054, 3442, 4191], '2Brigelius-Flohe': [432], 'Free': [434], 'Radical': [435], 'Med.': [437, 870], '1999;': [438, 754, 845, 924, 1312, 1381, 1596, 1813, 1890, 1929, 4876], '27:': [439], '951-965Google': [440], 'Scholar).': [441, 500, 540, 594, 626, 673, 713, 807, 848, 884, 945, 1004, 1315, 1395, 1465, 1599, 1816, 1893, 1947, 1985, 2082, 3169, 3926, 4081, 4207, 4240, 4302, 4433, 4545, 4816, 4879, 4938, 4959, 5029], 'Four': [442], 'GPx': [445, 447, 450, 453, 458, 484, 597, 765, 955, 1015, 1054, 1068, 1103, 1150, 1600, 1625, 1969, 2135, 2406, 2904, 2966, 3032, 3345, 3874, 4178, 4270, 4554, 4826, 5183], '(cGPx),': [448, 2188], '(GIGPx),': [451], '(eGPx),': [454, 2191], '(PHGPx))': [459], 'been': [461, 717, 2998, 4501, 4513], 'identified,': [462], 'each': [464, 1014, 1681, 1994, 2164, 2207, 2291, 2731, 2903, 2965, 3368, 3992, 4029], 'enzyme': [465, 477, 506, 603, 1036, 1051, 1682, 2168, 2208, 2272, 2292, 2377, 2700, 2732, 3036, 3093, 3369, 3501, 4057, 4718, 4818], 'antigenetically,': [467], 'structurally,': [468], 'enzymatically': [470], 'different.': [471], 'cGPx': [472, 1325, 1904, 2246, 2392, 2754, 2792, 2807, 3001, 3051, 3108, 3284, 3379, 3958, 4167, 4333, 4349, 4363, 4386, 4407, 4593, 5140], 'ubiquitously': [475], 'distributed': [476, 604], 'first': [481, 520, 1097, 2084, 3862], 'family': [485, 956, 1055, 2407, 3033, 3346, 4271, 5184], 'be': [487, 2884, 2946, 3147, 3779, 3854, 3997, 4132, 4321, 4465, 4571, 4823, 4839], 'discovered': [488], '(3Flohe': [489], 'Gunzler': [491, 2669, 3431, 4196], 'W.A.': [492, 2670, 3432, 4197], 'Schock': [493], 'H.H.': [494], 'FEBS': [495, 668], 'Lett.': [496, 669], '1973;': [497, 871], '32:': [498, 1445], '132-134Google': [499], 'GIGPx': [501], 'intracellular': [505], 'but': [507, 893, 2381, 3659, 3963, 4061, 4098, 4403], 'expressed': [509, 544, 1750], 'only': [510, 602, 2265, 3003, 4365, 4619], 'epithelium': [513], 'tract': [517], 'as': [518, 610, 721, 904, 978, 1034, 1193, 1292, 1333, 1361, 1403, 1432, 1626, 1751, 1909, 1970, 2016, 2039, 2121, 2155, 2415, 2443, 2471, 2500, 2528, 2564, 2652, 2681, 3005, 3019, 3176, 3416, 3457, 3468, 3482, 3515, 3637, 3654, 3686, 4020, 4141, 4170, 4222, 4367, 4381, 4525, 4659, 4685, 4698, 4829, 4841], 'line': [521, 3537], 'defense': [523], 'ingested': [525], 'lipid': [526, 4005, 4021, 4106, 5009], '(4Chu': [528], 'F.F.': [529, 4068, 5094], 'Doroshow': [530, 4073], 'J.H.': [531, 4074], 'Esworthy': [532], 'R.S.': [533, 4066], '1993;': [537, 1001, 1392, 1444, 3923, 4078], '268:': [538], '2571-2576Google': [539], 'eGPx': [541, 599, 678, 970, 1353, 1906, 2248, 2322, 2368, 2764, 2780, 3053, 3110, 3152, 3298, 3382, 3879, 4034, 4048, 4087, 4169, 4434, 4496, 4516, 5132], 'mainly': [543], 'kidneys': [547], 'where': [549], 'it': [550, 902, 1070, 3954, 4499, 4994], 'released': [552, 4944], 'into': [553, 1843, 4945], 'blood': [555, 1222, 1331, 2147, 5214], 'circulation': [556], '(5Takahashi': [557], 'Akasaka': [559], 'Yamamoto': [561], 'Y.': [562, 661, 829, 835, 908, 914, 995, 1296, 1302, 1365, 1371, 1386, 1580, 1586, 1797, 1803, 1858, 1874, 1880, 1913, 1919, 4890], 'Kobayashi': [563], 'C.': [564, 579, 706, 986, 1411, 1632, 1938, 1978, 2047, 4184, 4233, 4803], 'Mizoguchi': [565], 'Koyama': [567], 'Biochem.': [570, 621, 652, 999, 1202, 1390, 1864, 4076, 4429, 4931], '(Tokyo).': [571], '1990;': [572, 1637, 4908], '108:': [573, 5101], '145-148Google': [574], '6Avissar': [576], 'N.': [577, 615, 4888], 'Eisenmann': [578], 'Breen': [580], 'J.G.': [581], 'Horowitz': [582], 'S.': [583, 742, 4906], 'Miller': [584], 'R.K.': [585], 'Cohen': [586, 618], 'H.J.': [587], 'Am.': [588], 'Physiol.': [590, 2675, 3437, 4202], '1994;': [591, 654, 881, 1417, 1944, 3166, 4542], '267:': [592], 'E68-E76Google': [593], 'Of': [595], 'family,': [598], 'fluids': [608, 4886, 4982], 'such': [609, 977, 3901, 4019, 4140], 'plasma': [611, 863, 1226, 1360, 4149, 4480, 4947, 5050, 5065], '(7Takahashi': [612], 'Avissar': [614], 'Whitin': [616], 'H.': [619, 789, 933, 939, 1454, 4797, 4892], 'Arch.': [620, 651, 998, 1389, 4075], 'Biophys.': [622, 653, 708, 988, 1000, 1203, 1391, 1415, 1942, 1980, 2049, 4077, 4186, 4235, 4932], '1987;': [623], '256:': [624], '677-686Google': [625], 'PHGPx': [627, 681, 714, 770, 968, 1396, 2261, 2300, 2360, 3065, 3122, 3314, 3393, 4032, 4221, 4227, 4446, 5142], 'can': [628, 2883, 2945], 'reduce': [629, 957, 971, 3966, 4586, 4859], 'variety': [631], 'including': [634, 4583], 'integrated': [636], 'membranes,': [638], 'hydroperoxy': [639], 'lipids': [640, 976, 4146, 5195], 'low': [642, 4768], 'density': [643], 'lipoprotein': [644], '(8Sattler': [645], 'W.': [646, 3158, 4534], 'Stocker': [649], '309:': [655], '214-221Google': [656], 'Scholar),': [657, 757, 4911], 'or': [658, 1547, 1550, 2151, 2262, 2267, 2361, 3017, 3043, 3100, 3195, 3206, 3272, 3714, 3733, 3789, 3808, 4379, 4983], 'thymine': [659], '(9Bao': [660], 'Jemth': [662], 'Mannervik': [664], 'B.': [665, 3160, 4536, 4799, 4951], 'Williamson': [666, 1861], 'G.': [667, 1442, 1862, 2668, 3430, 4195], '1997;': [670, 4935, 5100], '410:': [671], '210-212Google': [672], 'Although': [674, 5060], 'are': [679, 775, 2738, 2783, 3776, 3851, 4357, 4399, 4404, 4486, 4627, 4707, 5133, 5143, 5175], 'homotetramers,': [680], 'monomer': [684], 'with': [685, 766, 1105, 1289, 1349, 1421, 1448, 1502, 1641, 1767, 1774, 1869, 1968, 2181, 2253, 2397, 3238, 3566, 3620, 3682, 4092, 4173, 4255, 4720, 4766, 4849, 4971, 4992, 5004, 5031], 'molecular': [687], 'size': [688], 'smaller': [689], 'than': [690, 2357, 2772, 2789, 2814, 3306, 3321, 3333, 3669, 4265, 4356, 4665], 'subunits': [692], 'other': [695, 2390, 2644, 2817, 3010, 3296, 4174, 4359, 4372, 4396, 4470, 4581], 'GPxs': [696, 4582], '(10Ursini': [697], 'Valente': [701], 'Ferri': [703], 'Gregolin': [705, 985, 1631, 1977, 2046, 4183, 4232], 'Biochim.': [707, 987, 1414, 1941, 1979, 2048, 4185, 4234], 'Acta.': [709, 989, 1416, 1943, 1981, 2050, 4187, 4236], '1982;': [710], '710:': [711], '197-211Google': [712], 'has': [715, 2997, 4500, 4512], 'recently': [716, 809], 'act': [720], 'structural': [723], 'component': [724], 'mitochondrial': [727], 'capsule': [728], 'thus': [730, 2003], 'needed': [732], 'formation': [735, 3246, 4729], 'flagellum': [738], '(11Ursini': [739], 'Heim': [741], 'Kiess': [743], 'Wissing': [749], 'Science.': [753], '285:': [755], '1393-1396Google': [756], 'whereas': [758, 2260, 2321, 3384, 3751, 3826], 'nuclei,': [761], 'sperm': [763], 'nuclei': [764], 'properties': [767], 'similar': [768, 2649, 4784], 'its': [772], 'processed': [773], 'products': [774, 3228], 'involved': [776], 'chromatin': [778], 'condensation': [779], 'germline': [784], 'damage': [787, 5054], '(12Pfeifer': [788], 'Conrad': [790], 'Roethlein': [792], 'Kyriakopoulos': [794], 'Brielmeier': [796], 'Bornkamm': [798], 'G.W.': [799], 'Behne': [800], 'FASEB': [802], '2001;': [804, 4813], '15:': [805], '1236-1238Google': [806], 'reported': [810, 2999, 3145, 4223, 4514, 4788, 4924], '(SeP),': [814], 'presumed': [815], 'contain': [817], 'ten': [818], 'residues,': [820], 'reduces': [821, 3257], 'GPx-like': [826], 'manner': [827], '(13Saito': [828, 907, 1295, 1364, 1579, 1796, 1873, 1912], 'Hayashi': [830, 909, 1297, 1366, 1581, 1798, 1875, 1914], 'T.': [831, 910, 1199, 1298, 1367, 1582, 1799, 1876, 1915, 4900, 5020], 'Tanaka': [832, 911, 1299, 1368, 1583, 1800, 1877, 1916], 'Watanabe': [834, 913, 1301, 1370, 1585, 1802, 1879, 1918], 'Suzuki': [836, 915, 1303, 1372, 1587, 1804, 1881, 1920], 'Saito': [838, 917, 1305, 1374, 1589, 1806, 1883, 1922], 'E.': [839, 918, 1306, 1339, 1375, 1590, 1807, 1884, 1923, 2672, 3434, 4199], 'Takahashi': [840, 919, 996, 1307, 1376, 1387, 1457, 1591, 1808, 1885, 1924], '274:': [846, 925, 1313, 1382, 1597, 1814, 1891, 1930], '2866-2871Google': [847, 926, 1314, 1383, 1598, 1815, 1892, 1931], 'SeP': [849, 889, 1107, 1140, 1355, 2141, 2263, 2333, 2350, 2409, 2597, 2766, 2782, 3067, 3124, 3188, 3196, 3205, 3237, 3256, 3325, 3396, 3413, 3508, 3565, 3578, 3681, 3747, 3822, 3882, 3977, 4125, 4253, 4259, 4303, 4325, 4448, 4584, 4664, 4680, 4736, 4837, 4972, 5001, 5045, 5077, 5083, 5112, 5130, 5186], 'protein': [853, 1532, 3896, 4548, 4555], 'major': [857], 'rat': [860], '(14Burk': [864], 'R.F.': [865, 876, 3917, 5012, 5088], 'Proc.': [866, 4901], 'Soc.': [867], 'Exp.': [868], '143:': [872], '719-722Google': [873], '15Burk': [875], 'Hill': [877, 3918, 5013, 5089], 'K.E.': [878, 3919, 5014, 5090], 'Nutr.': [880, 3922], '124:': [882], '1891-1897Google': [883], 'function': [887], 'currently': [891], 'unknown,': [892], 'reports': [895], 'led': [897, 2637], 'hypothesis': [900], 'antioxidant': [906], '16Arteel': [928], 'G.E.': [929], 'Mostert': [930], 'V.': [931], 'Oubrahim': [932], 'Briviba': [934], 'Abel': [936], 'Sies': [938], '1998;': [942], '379:': [943], '1201-1205Google': [944], 'It': [946, 4511], 'generally': [948], 'known': [949], 'all': [951, 2908, 2970, 3218, 3942, 4450], 'members': [952], 'expense': [962, 3262, 4590], '(GSH)': [965], 'more': [974, 2810, 3319, 3331, 4352, 4657], 'complex': [975, 4733], '(17Ursini': [981, 1973, 2042, 4179, 4228], '1985;': [990, 1982, 2051, 4188, 4237], '839:': [991, 1983, 2052, 4189, 4238], '62-70Google': [992, 1984, 2053, 4190, 4239], '18Yamamoto': [994, 1385], '305:': [1002, 1393], '541-545Google': [1003, 1394], 'However,': [1005, 3587, 5172], 'literature': [1007], 'shows': [1008, 4326], 'determined': [1017, 1088, 1109, 1135, 1762, 1908, 2210, 2220, 2512, 2576, 2733, 3635], 'using': [1018, 1119, 2221, 3040, 3084, 3097, 3141, 3509, 4681, 4866], 'kind': [1021], 'pH,': [1028], 'temperature,': [1029], 'GSH': [1031, 1172, 1614, 1622, 1669, 1766, 1772, 2115, 2614, 2635, 2813, 3271, 3291, 3305, 3352, 3510, 3521, 3672, 3683, 3720, 3738, 3795, 3813, 4355, 4366, 4410, 4443, 4455, 4481, 4508, 4524, 4568, 4596, 4616, 4643, 4682, 5062], 'concentration.': [1032, 1734], 'Furthermore,': [1033, 4939], 'obtained': [1038, 1162, 2004, 2751, 2762, 3559, 3647, 3656, 3718, 3793, 4164, 4219, 4675], '(human,': [1042], 'rat,': [1043], 'pig),': [1045], 'successful': [1047], 'comparison': [1048, 4668], 'would': [1056], 'appear': [1057], 'impossible.': [1058], 'consider': [1060], 'diversity,': [1069], 'compare': [1074], 'same': [1086, 1091, 2233, 2326, 2736, 3288, 3653, 4038, 4558, 4602], 'origin': [1087], 'under': [1089, 1491, 2157, 2199, 2231, 2295, 2399, 2734, 2897, 2959], 'conditions.': [1092, 1493, 2299], 'In': [1093, 1715, 3310, 3423], 'this': [1094, 3859, 4316, 4631], 'study,': [1095], 'we': [1096, 1144, 2989, 3888, 3928, 4575, 4626], 'together': [1104, 4765, 4848], 'kinds': [1121, 2223, 4136], 'synthetic': [1123], 'substrates.': [1125, 4332], 'compared': [1128, 3415, 4254], '(especially': [1131], 'thioredoxin)': [1132], 'Finally,': [1143, 4756], 'considered': [1145, 4821], 'diversity.': [1151], 'Tertiary': [1152], '(t-Bu-OOH),': [1155], 'cumene': [1156], 'hydroperoxide,': [1157, 1720], 'Nacalai,': [1164], 'Kyoto.': [1165], '1-Palmitoyl-2-linoleoyl-3-phosphatidylcholine': [1166], '(PC),': [1167], 'cholesteryl': [1168], 'linoleate,': [1169], 'reductase': [1173, 1426, 1670, 1773, 1776, 3194, 3203, 4941, 4967], 'Sigma.': [1176], 'Soybean': [1177], 'lipoxygenase': [1178, 1291], 'Biozyme': [1181], 'Laboratories': [1182], 'Ltd.': [1183], '(Blaenavon,': [1184], 'United': [1185], 'Kingdom).': [1186], 'Recombinant': [1187], '(TRX)': [1190], 'prepared': [1192, 1284], 'described': [1194, 1293, 1334, 1362, 1404, 1433, 1627, 1910, 1971, 2040, 2156, 2682, 2896, 2958, 3516, 5036], 'previously': [1195, 1294, 1335, 1363, 1405, 1434, 1628, 1911, 1972, 2041, 4224, 4820], '(19Mitsui': [1196], 'Hirakawa': [1198], 'Yodoi': [1200, 1455, 4897], 'Res.': [1204, 4933, 4955], 'Commun.': [1205, 4934], '1992;': [1206], '186:': [1207, 1638], '1220-1226Google': [1208], 'Scholar)': [1209, 1348, 1420, 1447, 1485, 1640, 1868, 2680, 3451, 5103], 'kindly': [1211, 1228, 1240], 'provided': [1212], 'Ajinomoto,': [1214], 'Co.': [1215, 1272], 'Inc.': [1216], '(Kawasaki,': [1217], 'Japan).': [1218, 1274], 'Human': [1219, 1237], 'out-dated': [1220], 'red': [1221, 1330, 2146], 'frozen': [1225], 'donated': [1229, 1241], 'Hokkaido': [1232, 1244, 5203], 'Red': [1233, 5204], 'Cross': [1234, 5205], 'Blood': [1235, 5206], 'Center.': [1236], 'placenta': [1238, 1431], 'Tonan': [1245, 5209], 'Hospital.': [1246], 'Distilled': [1247], 'water': [1248, 1253, 1537], 'further': [1250, 5173], 'purifier': [1254], '(Organo': [1255], 'Puric': [1256], 'model-S)': [1257], 'high-performance': [1259], 'chromatography': [1261], '(HPLC).': [1262], 'Acetonitrile': [1263], '(HPLC': [1264], 'grade)': [1265], 'purchased': [1267], 'Wako': [1269], 'Pure': [1270], 'Chemical': [1271], '(Osaka,': [1273], 'Methanol': [1275], '2-propanol': [1277, 1827], 'distilled': [1279, 1536], 'before': [1280], 'use.': [1281], 'PC-OOH': [1282, 1784, 2275, 2282, 2304, 2335, 2352, 2380, 2398, 2761, 3061, 3118, 3186, 3233, 3243, 3389, 3505, 3533, 3567, 4060, 4118, 4216, 4264], 'PC': [1286], 'oxidation': [1288, 1607, 1736, 2088], 'soybean': [1290], 'Other': [1316], 'chemicals': [1317], 'highest': [1321, 2308, 2795, 4336], 'quality': [1322], 'commercially': [1323], 'available.': [1324], '(20Awasthi': [1336], 'Y.C.': [1337], 'Beutler': [1338], 'Srivastava': [1340], 'S.K.': [1341], '1975;': [1345], '250:': [1346], '5144-5149Google': [1347], 'slight': [1351, 1423, 1643, 1871, 2266], 'modification.': [1352, 1424, 1644], 'placental': [1401], 'cytosol': [1402], '(21Roveri': [1406], 'Nisii': [1410, 1937], 'Ursini': [1412, 1633, 1939, 2071], '1208:': [1418, 1945], '211-221Google': [1419, 1946], 'TRX': [1425, 1758, 1768, 1775, 3143, 3175, 3193, 3202, 3207, 3239, 3273, 3317, 3328, 3338, 3358, 3569, 3591, 3649, 3665, 3685, 3754, 3829, 4521, 4547, 4566, 4598, 4654, 4684, 4739, 4747, 4774, 4794, 4830, 4844, 4846, 4850, 4880, 4916, 4940, 4964, 4966, 5068, 5114], '(22Oblong': [1435], 'J.E.': [1436], 'Gasdaska': [1437], 'P.Y.': [1438], 'Sherrill': [1439], 'Powis': [1441], 'Biochemistry.': [1443], '7271-7277Google': [1446], 'some': [1449, 3210], 'modifications': [1450], '(23Yarimizu': [1451], 'Nakamura': [1453], 'Antioxid.': [1459], 'Redox': [1460], 'Signal.': [1461], '2000;': [1462, 4956], '2:': [1463], '643-651Google': [1464], 'Sodium': [1466], 'dodecyl': [1467, 2177], 'sulfate-polyacrylamide': [1468, 2178], 'gel': [1469, 1499, 1521, 2179], 'electrophoresis': [1470, 2180], 'performed': [1472, 1572], 'according': [1473], 'method': [1476], 'Laemmli': [1478], '(24Laemmli': [1479], 'U.K.': [1480], 'Nature.': [1481], '1970;': [1482], '227:': [1483], '680-685Google': [1484], 'slab': [1487], 'gels': [1488], '(12.5%': [1489], 'gel)': [1490], 'reducing': [1492, 2200, 3021, 4119, 4383, 4687, 4712], 'After': [1494, 1559, 1817], 'electrophoresis,': [1495], 'proteins': [1496, 3220, 4865], 'stained': [1501, 2173], '0.1%': [1503, 2313, 2423, 2451, 2479, 2536], 'Coomassie': [1504], 'Brilliant': [1505], 'Blue': [1506], 'G-250': [1507], '10%': [1509, 1525], 'acetic': [1510, 1526], 'acid': [1511, 1527, 1555, 1569, 2099, 2106, 2214, 2516, 2580, 4318, 4462], '30%': [1513, 1529], 'methanol': [1514], '30': [1516], 'min,': [1517, 1700], 'then': [1519, 2006, 2109], 'destained': [1523], 'methanol.': [1530], 'dialyzed': [1534], 'hydrolyzed': [1539], '6': [1541], 'm': [1542, 1553, 1652, 3556, 3626, 4770], 'HCl': [1543], '24,': [1545], '48,': [1546], '72': [1548], 'h': [1549], '3': [1552, 2001, 3250, 3422], 'mercaptoethanesulfonic': [1554], '24': [1557], 'h.': [1558], 'removal': [1561, 4975], 'solvent': [1564], 'vacuo,': [1566], 'quantitative': [1567, 2212, 2514, 2578], 'amino': [1568, 2213, 2515, 2579, 4317, 4461], 'analysis': [1570, 1949, 3224], 'PICO-TAG': [1575], 'system': [1576, 3900], '(Water,': [1577], 'Millipore)': [1578], 'following': [1605, 1954, 2600, 4695], 'NADPH': [1609, 1738, 1754, 4867], 'presence': [1612, 2371, 4051, 4724, 5057], 'reductase,': [1615, 4851], 'which': [1616, 1702, 4852], 'oxidized': [1621, 1755, 2718, 4142, 4145, 4735, 5191, 5194], 'formed': [1623], '(25Maiorino': [1629], '448-457Google': [1639], 'Both': [1645], 'samples': [1646], 'reference': [1648], 'cuvettes': [1649], 'contained': [1650], '0.1': [1651], 'Tris-HCl,': [1653], 'pH': [1654, 2241], '7.4,': [1655, 2242], '0.2': [1656], 'mm': [1657, 1660, 1663, 2236, 2318, 2330, 2343, 2419, 2428, 2438, 2447, 2456, 2466, 2475, 2484, 2494, 2532, 2541, 2551], 'NADPH,': [1658], '0.5': [1659], 'EDTA,': [1661], '2': [1662, 1699, 2131, 3026, 3046, 3103, 3549, 3585, 3613, 3749, 3824], '1': [1666, 1676, 1999, 2029, 2125, 2129, 2693, 2726, 2744, 2758, 2829, 2868, 2930, 3473, 3630, 3645, 3716, 3791, 4156, 4210, 4245, 4700], 'unit': [1667], 'total': [1673], 'volume': [1674, 1824], 'ml.': [1677], 'An': [1678, 1834], 'aliquot': [1679, 1835], 'added': [1684, 1726, 1829], 'sample': [1687], 'cuvette': [1688], 'only.': [1689], 'reaction': [1691, 1704, 1729, 1820, 1832, 1838, 1991, 2595, 2872, 2934, 3227, 4719], 'mixture': [1692, 1730, 1839], 'preincubated': [1694], '37': [1696, 1745, 2244], '°C': [1697], 'after': [1701], 'started': [1706], 'addition': [1709], 'cuvettes.': [1714], 'case': [1717, 2019, 2366, 3312, 3640, 4046, 4791], 'Triton': [1721, 2314, 2339, 2373, 2424, 2434, 2452, 2462, 2480, 2490, 2537, 2547, 4053, 4082], 'X-100': [1722, 2315, 2340, 2374, 2425, 2435, 2453, 2463, 2481, 2491, 2538, 2548, 4054, 4083], 'deoxycholate': [1724], 'appropriate': [1733], 'followed': [1740, 2799, 4340], '340': [1742], 'nm': [1743], '°C,': [1746], 'micromoles': [1752], 'per': [1756], 'minute.': [1757], 'analogously': [1763], 'replacing': [1765], '(1–100': [1769, 3360], 'μm)': [1770, 3361], '(5': [1777], 'nm).': [1778], 'confirm': [1780], 'examine': [1786, 1895], 'specificity,': [1789, 1898], 'HPLC': [1791, 1845, 1848, 3071, 3128, 3223], 'assay': [1792, 2273], 'conducted': [1795], 'incubating': [1818], 'mixture,': [1821], '9-fold': [1823], 'ice-cold': [1826], 'mixture.': [1833], 'injected': [1841], 'directly': [1842], 'system.': [1846], 'conditions': [1849, 2201, 2234, 2413, 2441, 2469, 2526, 2737, 3983, 4114], 'basically': [1851], 'those': [1852, 3307, 3752, 3827], 'Bao': [1854], 'et': [1855], 'al.': [1856], '(26Bao': [1857], 'Chambers': [1859], 'S.J.': [1860], 'Anal.': [1863], '224:': [1866], '395-399Google': [1867], 'modification': [1872], 'H2O2': [1902, 2749, 3961, 4162], '21Roveri': [1933], 'Kinetic': [1948], 'carried': [1951], 'out': [1952], 'time': [1956, 1995, 2602], 'progress': [1957, 2603], 'curves': [1958, 2604], 'consumption': [1961, 2607], '(NADPH': [1962, 2608], 'oxidation)': [1963, 2609], 'coupled': [1966], 'test': [1967], 'concentration': [1988, 2205, 2510, 2574, 5063, 5110], 'rate': [1992, 2026, 2502, 2566, 2820, 2865, 2927, 3471, 3767, 3842], 'interval': [1996], '(typically': [1997], 'min)': [2002], 'fitted': [2007], 'Dalziel': [2010, 2037, 3425], 'equation,': [2011], 'indicating': [2012, 2805], 'ping-pong': [2014, 2660, 3513, 3582], 'mechanism': [2015, 2591, 2661, 3514, 3907], 'PHGPx.': [2024, 2791], 'constants': [2027, 2821, 2866, 2928], 'k': [2028, 2031, 2692, 2703, 2725, 2728, 2796, 2867, 2929, 2981, 3485, 3629, 3632, 3644, 3661, 3715, 3734, 3762, 3790, 3809, 3837, 4155, 4244, 4247, 4337, 4639, 4759], '2′': [2032, 2704, 2729, 2797, 2874, 2900, 2936, 2962, 2982, 3486, 3633, 3662, 3735, 3810, 4248, 4338, 4640, 4760], 'calculated': [2034, 2885, 2947, 4751], 'coefficients': [2038, 4674], '27Maiorino': [2055], 'Doria': [2061], 'van': [2063], 'den': [2064], 'Heuvel': [2065], 'McCarthy': [2067], 'Hoppe': [2077], 'Seyler.': [2078], '376:': [2080], '651-660Google': [2081], 'step': [2085, 2697, 3758, 3833], 'selenol': [2090, 2119], 'anion': [2091, 2120], '(E-Se−)': [2092], 'yield': [2096, 2117], 'selenenic': [2098, 2105], 'derivative': [2100, 2107], '(E-SeOH)': [2101], 'hydroxide.': [2103], 'Equations': [2124], '2.': [2127], 'E\xadSe−+H++R\xadOOH→k1E\xadSeOH+R\xadOHEquation': [2128], 'E\xadSeOH+2GSH→k2′E\xadSe−+H++GSSG+H2OEquation': [2130], 'Three': [2132], '(cGPx,': [2136], 'PHGPx)': [2139], 'cells,': [2148, 5170, 5215], 'plasma,': [2150, 5216], 'placenta,': [2153], 'respectively,': [2154, 2891, 2953], '“Experimental': [2158, 2898, 2960], 'Procedures.”': [2159], 'As': [2160, 2979, 2996, 3573, 3937, 3949, 4361, 4624], 'Fig.1,': [2163], 'preparations': [2169], 'gave': [2170], 'single': [2172], 'band': [2174], 'sodium': [2176, 2319, 2331, 2344, 2420, 2429, 2439, 2448, 2457, 2467, 2476, 2485, 2495, 2533, 2542, 2552], 'mobility': [2183], 'corresponding': [2184], '23': [2186, 2189], 'kDa': [2187, 2190, 2193, 2197], '20': [2192], '(PHGPx),': [2194], '69': [2196], '(SeP)': [2198], '(Fig.': [2202, 3249, 3282, 3548, 3584, 3612, 4689], '1).': [2203], 'analyses.': [2215], 'Specific': [2216], '(TableI)': [2218], 'substrate,': [2226], 'H2O2,': [2228, 2259], '(2': [2235], '60': [2238], 'μm': [2239, 4485], 'peroxide,': [2240], '°C).': [2245], 'showed': [2249, 2264, 2323, 2648, 2793, 3198, 3285, 3580, 4035, 4334], 'superior': [2251], 'reactivity': [2252, 2396, 3289], 'water-soluble': [2255], 'substrates,': [2256], 't-Bu-OOH': [2257, 2384, 2747, 3375, 4064], 'almost': [2268, 2324, 2394, 3286, 4037, 4600], 'no': [2269, 2395, 3199], 'reactivity.': [2270], 'needs': [2277], 'detergent': [2279, 2298, 2401, 3982, 4113], 'solubilize': [2281], 'buffer,': [2285], 'optimum': [2288, 3981, 4030], 'acquired': [2294], '0.24': [2317, 2427, 2455, 2483, 2540], 'deoxycholate,': [2320, 2421, 2430, 2449, 2458, 2477, 2486, 2534, 2543], '7': [2329, 2418, 2446, 2474, 2531], 'deoxycholate.': [2332, 2345, 2553], 'optimally': [2336], '0.025%': [2338, 2433, 2461, 2489, 2546], '0.3': [2342, 2437, 2465, 2493, 2550], 'one': [2354, 4305, 4415], 'order': [2355], 'lower': [2356, 2375, 2771, 3302, 4055, 4243, 4328, 4475], 'eGPx.': [2362, 2756], 'Only': [2363, 4043], 'did': [2369, 3208, 3605, 4049], 'not': [2382, 2386, 2837, 2849, 2851, 2857, 2859, 2918, 3606, 3725, 3800, 3965, 4062, 4085, 4400, 4487, 4715], '(data': [2385], 'shown).': [2387], 'On': [2388, 3294], 'hand,': [2391, 3297], 'had': [2393], 'any': [2400, 2816], 'conditions.Table': [2402], 'ISpecificity': [2403], 'substratest-BuOOHH2O2PC-OOH1)aDetergent': [2412], 'varied': [2414, 2442, 2470, 2527, 2984], 'follows:': [2416, 2444, 2472, 2529], '1)': [2417, 2445, 2473, 2530], '2)': [2422, 2450, 2478, 2535], '3)': [2432, 2460, 2488, 2545], 'deoxycholate.2)aDetergent': [2440], 'deoxycholate.3)aDetergent': [2468], 'deoxycholate.cGPx552793<0.02<0.02<0.02eGPx19937354.10.030.18PHGPx9.5634.82.6564.828.8SeP<0.02<0.02<0.021.111.15The': [2496], 'measured': [2499, 2563, 3039, 3055, 3069, 3096, 3112, 3126, 3377, 3391], 'initial': [2501, 2565], 'corrected': [2504, 2568], 'spontaneous': [2507, 2571], 'reaction.': [2508, 2572], 'Enzyme': [2509, 2573], 'analysis.': [2517, 2581, 3072, 3129, 4834], 'Each': [2518, 2582, 3073, 3092, 3130], 'value': [2519, 2583, 2798, 3646, 3663, 4211, 4339, 4761, 4771], 'presented': [2521, 2585], 'μmol/min/mg': [2523, 2587], 'protein.a': [2524], 'Detergent': [2525], 'Open': [2554, 2920, 3086, 3781], 'table': [2555, 2921, 3087, 3782], 'new': [2558, 2924, 3090, 3785], 'tab': [2559, 2925, 3091, 3786], 'protein.': [2588], 'GSH-dependent': [2594, 3576], 'studied': [2599], 'fixed': [2613], 'concentrations.': [2615], 'From': [2616], 'curves,': [2618], 'reciprocal': [2620, 2628, 3459, 3470, 3484, 3520, 3525, 3590, 3595], 'concentrations': [2621, 2636, 3024, 3303, 3522, 3531, 3592, 3771, 3846, 4482], 'plotted': [2625], 'velocities': [2629], '12-s': [2631], 'intervals,': [2632], 'parallel': [2639], 'lines': [2640], '(Fig.2': [2641], 'A).': [2642, 3192], 'patterns': [2651, 4671], 'typical': [2654], 'bi-substrate': [2656], 'reactions': [2657, 3411, 3723, 3798, 4706], 'displaying': [2658], 'without': [2662], 'apparent': [2663, 3526, 3956], 'saturation': [2664, 3618, 4763], '(28Flohe': [2665, 3427], 'Loschen': [2667, 3429, 4194], 'Eichele': [2671, 3433, 4198], "Hoppe-Seyler's": [2673, 3435, 4200], 'Z.': [2674, 3436, 4201], '1972;': [2677, 3439, 4204], '353:': [2678, 3440, 4205], '987-999Google': [2679, 3441, 4206], 'detail': [2684], 'below.': [2685], 'This': [2686, 2777, 3615, 4346, 4561, 4604, 4817], 'allowed': [2687], 'distinct': [2689], 'measurement': [2690], 'sum': [2707, 2877, 2939, 3489, 3741, 3816], 'reductive': [2711, 2881, 2943, 3493, 3744, 3757, 3819, 3832], 'steps': [2712, 2882, 2944, 3494, 3745, 3820], 'regeneration': [2715, 3497], 'GSH.': [2721, 3085, 3142, 3323, 3503, 3642, 4478, 4666], 'values': [2723, 2745, 2759, 2901, 2963, 2983, 3557, 3717, 3736, 3792, 3811, 4157, 4249, 4641, 4701], 'TableII.': [2741], 'Essentially': [2742], 'identicalk': [2743], 'Thek': [2757], '40-fold': [2768], '200-fold': [2770], 'respectively.': [2776, 5171], 'indicates': [2778, 3616, 4347, 4693], 'less': [2784, 4261], 'reactive': [2785, 2811, 4133, 4262, 4353], 'significantly': [2809, 3727, 3802, 4351], 'enzyme.Table': [2818], 'IISecond-order': [2819], 'peroxides': [2823, 4022], '(k1)': [2824], '(k': [2827], '2′)k': [2828], '(m−1sec−1)K': [2830], '2′(m−1': [2831], 'sec−1)t-BuOOHH2O2PC-OOHcGPx4.2': [2832], '×': [2833, 2835, 2839, 2841, 2843, 2845, 2847, 2853, 2855, 2861, 2863, 3695, 3697, 3699, 3701, 3703, 3705, 3707, 3709, 3711, 4754], '1064.1': [2834], '107n.d.an.d.,': [2836], 'determined.2.3': [2838], '105eGPx2.3': [2840], '1064.0': [2842], '1073.4': [2844], '1057.9': [2846], '104PHGPxn.d.an.d.,': [2848], 'determined.n.d.an.d.,': [2850, 2858], 'determined.1.5': [2852], '1075.7': [2854], '104SePn.d.an.d.,': [2856], 'determined.8.6': [2860], '1044.9': [2862], '102The': [2864], 'andk': [2873, 2935], 'slope': [2888, 2950, 3604], 'intercept,': [2890, 2952], 'Lineweaver-Burk': [2894, 2956], 'plot': [2895, 2957], 'Procedures.”k': [2899, 2961], 'averaged': [2906, 2968], 'experiments': [2911, 2973], 'irrespective': [2912, 2974], 'substrate.a': [2916], 'n.d.,': [2917], 'substrate.': [2978], 'reexamined': [2991, 3985], '(TableIII).': [2995], 'previously,': [3000], 'donor.': [3008, 4370], 'could': [3013, 4375], 'use': [3014, 4376, 4520], 'dithiothreitol,': [3015, 3041, 3098, 4377], 'mercaptoethanol,': [3016, 3042, 3099, 4378], 'cysteine': [3018, 3044, 3101, 4380], 'substance': [3022], 'mm.Table': [3027], 'IIIThiol': [3028], 'SePGSHDithiothreitolMercaptoethanolCysteinecGPx(100)<2<2<2eGPx(100)16967.659.5PHGPx(100)51065.615.4SeP(100)43531.659.0Each': [3035], 'mm.': [3047, 3104], 'H2O2reduction': [3048, 3105], 'scopoletin': [3057, 3114], 'assay,': [3058, 3115], 'converted': [3076, 3133], 'percentage': [3079, 3136], 'when': [3083, 3140, 3217, 3769, 3844], '(29Bjornstedt': [3153, 4529], 'Xue': [3155, 4531], 'Huang': [3157, 4533], 'Akesson': [3159, 4535], 'Holmgren': [3161, 4537, 4872], '269:': [3167, 4543], '29382-29384Google': [3168, 4544], 'investigate': [3171], 'possibility': [3173], 'TRX-dependent': [3183, 3410, 4705], '(Fig.3': [3191], 'alone': [3197], 'activity,': [3200], 'although': [3201], 'show': [3209, 4473], 'activity.': [3211, 5079], 'maximum': [3213, 3462, 4117], 'observed': [3216, 3574, 4172, 4251], 'added.': [3222], 'confirmed': [3229], 'conversion': [3231], 'PC-OH': [3235], '(the': [3240], 'loss': [3241], 'PC-OH)': [3248], 'B).': [3251, 3550], 'results': [3253, 5035], 'indicate': [3254, 4126, 4772, 4962], 'TRX.': [3264, 3293, 3309, 3761, 3836, 4592, 4652, 5059], 'effect': [3269, 3350], 'dose': [3274, 3362], '4).': [3283], 'effective': [3320, 3332, 4658], 'When': [3324], 'used,': [3327], '500-fold': [3330, 4656], 'GSH.Figure': [3334], '4Dose': [3335], 'dependence': [3336], 'SeP.': [3348, 4345, 4781], '(●)': [3353], '(1': [3354], 'μm-5': [3355], 'mm)': [3356], '(○)': [3359], 'examined.': [3371], 'Reduction': [3372], '(A)': [3380], '(B),': [3383], '(C)': [3394], '(D).View': [3397], 'Large': [3398], 'Image': [3399], 'Figure': [3400], 'ViewerDownload': [3401], '(PPT)': [3402], 'mechanisms': [3405], 'GSH-': [3408, 4703], 'Equation': [3419], '3.': [3420], '[E]/v=Φ0+Φ1/[ROOH]+[Φ2]/[thiol]Equation': [3421], 'equation': [3426], '30Dalziel': [3443], 'Acta': [3445], 'Scand.': [3447], '1957;': [3448], '11:': [3449], '1706-1723Google': [3450], 'above,': [3453, 5037], 'Φ0': [3454, 3545], 'defined': [3456, 3467, 3481, 3621, 4749, 4840], 'turnover': [3463], 'number,': [3464], 'Φ1': [3465, 3713, 3788], 'constantk': [3472], 'reaction,': [3477], 'Φ2': [3479, 3732, 3807], 'revealed': [3511, 3598], 'above.': [3517], 'Replotting': [3518], 'V': [3527, 3623], 'max': [3528, 3553, 3597], 'infinite': [3530], 'yielded': [3534], 'straight': [3536], 'cutting': [3538], 'ordinate': [3540, 3609], 'origin,': [3541], 'i.e.': [3542], 'coefficient': [3544], 'approximates': [3546], 'zero': [3547, 3611], 'Accordingly,': [3551], 'infiniteV': [3552], 'K': [3555, 4744, 4769], '(Table': [3560, 3673], 'IV).': [3561], 'kinetics': [3563, 3619, 4764], 'analyzed': [3571], 'next.': [3572], 'reduction,': [3577], 'pattern': [3583, 4786], 'C).': [3586], 'replotting': [3588], 'apparentV': [3596], 'difference': [3600], 'cut': [3607], 'D).': [3614], 'Michaelis-Menten-type': [3617, 4732], 'Φ0,': [3622], 'max,': [3624], 'andK': [3625], 'values.': [3627], 'similarly': [3636], 'essentially': [3651], '400-times': [3667], 'higher': [3668], 'IV).Table': [3674], 'IVCompilation': [3675], 'data': [3679], 'substrateDonor': [3689], 'substrateΦ0Φ1k': [3690], '1Φ2k': [3691], '2′K': [3692], 'mSHk': [3693], 'catsmsm−1s−1msm−1s−1ms−1GSH01.17': [3694], '10−58.5': [3696], '1042.07': [3698], '10−34.8': [3700], '102∞∞TRX0.7371.41': [3702], '10−57.1': [3704], '1044.83': [3706], '10−62.1': [3708], '1056.5': [3710], '10−61.4The': [3712], 'TRX-driven': [3722, 3797], 'do': [3724, 3799], 'within': [3728, 3803], 'experimental': [3729, 3804], 'error.': [3730, 3805], 'represent': [3739, 3755, 3814, 3830, 5070], 'mGSH,': [3750, 3825], '1m': [3760, 3835], 'cat': [3763, 3838], 'represents': [3764, 3839], 'overall': [3766, 3841], 'constant': [3768, 3843], 'substrates': [3775, 3850, 4018], 'assumed': [3777, 3852], 'infinite.': [3780, 3855], 'our': [3857, 5032], 'knowledge,': [3858], 'origins.': [3886, 3936], 'Unfortunately,': [3887], 'cannot': [3889], 'obtain': [3890], 'full-length': [3892], 'recombinant': [3893], 'mammalian': [3894, 4177], 'selenocysteine-containing': [3895, 4856], 'expression': [3899, 4914], 'asEscherichia': [3902], 'coli,': [3903], 'because': [3904, 4607], 'translational': [3906], 'differs': [3910], 'markedly': [3911], 'between': [3912], 'eukaryotes': [3913], 'prokaryotes': [3915], '(31Burk': [3916], 'Annu.': [3920], 'Rev.': [3921], '13:': [3924], '65-81Google': [3925], 'Therefore,': [3927, 4385, 4574], 'isolated': [3930], 'Fig.': [3940], '1,': [3941], 'highly': [3947], 'purified.': [3948], 'Table': [3952, 4691], 'I,': [3953], 'reducest-Bu-OOH': [3959], 'effectively': [3962], 'does': [3964, 4714], 'PC-OOH.': [3967, 4042, 4721], 'determine': [3969, 4578], 'enzymatic': [3971, 5078], 'enzyme.': [3993], 'differences': [3995, 4109], 'may': [3996, 4084, 4099, 4320, 4464, 4570, 4838, 4969, 5069], 'attributed': [3998], 'physical': [4001, 4102], 'state': [4002, 4103], 'interface,': [4006], 'suggesting': [4007, 4257], 'reactivities': [4014, 5180], 'naturally': [4016], 'occurring': [4017], 'lipoproteins': [4024, 4143, 5192], 'cell': [4026, 4986, 5117, 5198], 'membranes.': [4027], 'Under': [4028], 'condition,': [4031], '(32Esworthy': [4065], 'Chu': [4067], 'Geiger': [4069], 'Girotti': [4071], 'A.W.': [4072], '307:': [4079], '29-34Google': [4080], 'inhibit': [4086], 'through': [4089], 'interaction': [4091], 'active': [4096, 4274, 4309], 'site': [4097, 4412], 'influence': [4100], 'interface.': [4107], 'required': [4112], 'might': [4131, 4509, 5104], 'membrane': [4150, 5051], 'High': [4154], '(beyond': [4158, 4212], '107m−1': [4159, 4213], 's−1)': [4160, 4214], 'commonly': [4171], '28Flohe': [4192], 'A': [4208, 4667], 'highk': [4209], 'porcine': [4226], 'Approximately,': [4241], '100-fold': [4242], 'PH-GPx.': [4266], 'All': [4267], 'contains': [4272, 4408], 'triad': [4275], 'consisting': [4276, 4413], 'selenocysteine,': [4278], 'glutamine,': [4279], 'tryptophan': [4281, 4312], 'residues': [4282, 4420, 4440, 4452, 4463], 'lacks': [4304, 4435], 'element': [4306], 'triad,': [4310], 'residue.': [4313], 'Deletion': [4314, 4458], 'residue': [4319], 'reason': [4323, 4467], 'why': [4324, 4468], 'enzymes.': [4360], 'expected,': [4362], 'substance.': [4384], 'true': [4389], 'whereas,': [4392], 'strictly': [4393], 'speaking,': [4394], 'peroxidases.': [4406], 'binding': [4411, 4444, 4456, 5081], 'lysine': [4416], 'arginine': [4419, 4439], '(33Epp': [4421], 'O.': [4422], 'Ladenstein': [4423], 'Wendel': [4425], 'Eur.': [4427], '1983;': [4430], '133:': [4431], '51-69Google': [4432], 'site.': [4445, 4457], 'lack': [4449], 'five': [4451], 'Because': [4479], 'below': [4483], '10': [4484], 'able': [4488, 4518], 'maintain': [4490], 'sufficient': [4492], 'capacity': [4494], 'implied': [4502], 'physiologic': [4505], 'besides': [4507], 'exist.': [4510], 'instead': [4522], 'Interestingly,': [4546, 4782], 'amino-terminal': [4551], 'half': [4552], 'share': [4556], 'structure.': [4560], 'finding': [4562], 'suggests': [4563], 'systems': [4569], 'evolutionarily': [4572], 'related.': [4573], 'tried': [4576], 'whether': [4579], 'uses': [4594], 'rate.': [4603], 'seems': [4605], 'odd': [4606], 'previous': [4608], 'studies': [4609, 5041, 5174], 'indicated': [4614], 'cGPx.': [4623], 'present,': [4625], 'unable': [4628], 'explain': [4630], 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