Publication Information

{'id': 'https://openalex.org/W2099364141', 'doi': 'https://doi.org/10.1038/nature01036', 'title': 'Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress', 'display_name': 'Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress', 'publication_year': 2002, 'publication_date': '2002-09-01', 'ids': {'openalex': 'https://openalex.org/W2099364141', 'doi': 'https://doi.org/10.1038/nature01036', 'mag': '2099364141', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/12239572'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1038/nature01036', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S137773608', 'display_name': 'Nature', 'issn_l': '0028-0836', 'issn': ['0028-0836', '1476-4687'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319908', 'host_organization_name': 'Nature Portfolio', 'host_organization_lineage': ['https://openalex.org/P4310319908', 'https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Nature Portfolio', 'Springer Nature'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://dspace.library.uu.nl/bitstream/handle/1874/14139/9.Kops%202002%20pp%20316-321.pdf?sequence=1&isAllowed=y', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5086763911', 'display_name': 'Geert J.P.L. Kops', 'orcid': 'https://orcid.org/0000-0003-3555-5295'}, 'institutions': [{'id': 'https://openalex.org/I193662353', 'display_name': 'Utrecht University', 'ror': 'https://ror.org/04pp8hn57', 'country_code': 'NL', 'type': 'education', 'lineage': ['https://openalex.org/I193662353']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Geert J. P. L. Kops', 'raw_affiliation_strings': ['Department of Physiological Chemistry, University Medical Center Utrecht and Center for Biomedical Genetics, 3584 CG Utrecht, The Netherlands.'], 'affiliations': [{'raw_affiliation_string': 'Department of Physiological Chemistry, University Medical Center Utrecht and Center for Biomedical Genetics, 3584 CG Utrecht, The Netherlands.', 'institution_ids': ['https://openalex.org/I193662353']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5027333160', 'display_name': 'Tobias B. Dansen', 'orcid': 'https://orcid.org/0000-0001-5259-8815'}, 'institutions': [{'id': 'https://openalex.org/I193662353', 'display_name': 'Utrecht University', 'ror': 'https://ror.org/04pp8hn57', 'country_code': 'NL', 'type': 'education', 'lineage': ['https://openalex.org/I193662353']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Tobias B. Dansen', 'raw_affiliation_strings': ['Department of Biochemistry of Lipids, Institute of Biomembranes, Utrecht University, Utrecht, The Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry of Lipids, Institute of Biomembranes, Utrecht University, Utrecht, The Netherlands', 'institution_ids': ['https://openalex.org/I193662353']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5002662503', 'display_name': 'Paulien E. Polderman', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I3018483916', 'display_name': 'University Medical Center Utrecht', 'ror': 'https://ror.org/0575yy874', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I3018483916']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Paulien E. Polderman', 'raw_affiliation_strings': ['Department of Physiological Chemistry, University Medical Center Utrecht and Center for Biomedical Genetics, Utrecht, The Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Department of Physiological Chemistry, University Medical Center Utrecht and Center for Biomedical Genetics, Utrecht, The Netherlands', 'institution_ids': ['https://openalex.org/I3018483916']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5056409348', 'display_name': 'Ingrid Saarloos', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I3018483916', 'display_name': 'University Medical Center Utrecht', 'ror': 'https://ror.org/0575yy874', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I3018483916']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Ingrid Saarloos', 'raw_affiliation_strings': ['Department of Physiological Chemistry, University Medical Center Utrecht and Center for Biomedical Genetics, Utrecht, The Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Department of Physiological Chemistry, University Medical Center Utrecht and Center for Biomedical Genetics, Utrecht, The Netherlands', 'institution_ids': ['https://openalex.org/I3018483916']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5015270551', 'display_name': 'K.W.A. Wirtz', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I193662353', 'display_name': 'Utrecht University', 'ror': 'https://ror.org/04pp8hn57', 'country_code': 'NL', 'type': 'education', 'lineage': ['https://openalex.org/I193662353']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Karel W. A. Wirtz', 'raw_affiliation_strings': ['Department of Biochemistry of Lipids, Institute of Biomembranes, Utrecht University, Utrecht, The Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry of Lipids, Institute of Biomembranes, Utrecht University, Utrecht, The Netherlands', 'institution_ids': ['https://openalex.org/I193662353']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5067990066', 'display_name': 'Paul J. Coffer', 'orcid': 'https://orcid.org/0000-0001-8775-1939'}, 'institutions': [{'id': 'https://openalex.org/I3018483916', 'display_name': 'University Medical Center Utrecht', 'ror': 'https://ror.org/0575yy874', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I3018483916']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Paul J. Coffer', 'raw_affiliation_strings': ['Department of Pulmonary Diseases, University Medical Center, Utrecht, The Netherlands.'], 'affiliations': [{'raw_affiliation_string': 'Department of Pulmonary Diseases, University Medical Center, Utrecht, The Netherlands.', 'institution_ids': ['https://openalex.org/I3018483916']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5024528481', 'display_name': 'Ting-T. Huang', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I180670191', 'display_name': 'University of California, San Francisco', 'ror': 'https://ror.org/043mz5j54', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I180670191']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Ting-T. Huang', 'raw_affiliation_strings': ['[Department of Pediatrics, University of California, San Francisco, USA]'], 'affiliations': [{'raw_affiliation_string': '[Department of Pediatrics, University of California, San Francisco, USA]', 'institution_ids': ['https://openalex.org/I180670191']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5012633181', 'display_name': 'Johannes L. Bos', 'orcid': 'https://orcid.org/0000-0002-5656-2091'}, 'institutions': [{'id': 'https://openalex.org/I3018483916', 'display_name': 'University Medical Center Utrecht', 'ror': 'https://ror.org/0575yy874', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I3018483916']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Johannes L. Bos', 'raw_affiliation_strings': ['Department of Physiological Chemistry, University Medical Center Utrecht and Center for Biomedical Genetics, Utrecht, The Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Department of Physiological Chemistry, University Medical Center Utrecht and Center for Biomedical Genetics, Utrecht, The Netherlands', 'institution_ids': ['https://openalex.org/I3018483916']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5074565662', 'display_name': 'René H. Medema', 'orcid': 'https://orcid.org/0000-0002-6754-0381'}, 'institutions': [{'id': 'https://openalex.org/I2898336195', 'display_name': 'The Netherlands Cancer Institute', 'ror': 'https://ror.org/03xqtf034', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2898336195']}, {'id': 'https://openalex.org/I4210111138', 'display_name': 'Oncode Institute', 'ror': 'https://ror.org/01n92vv28', 'country_code': 'NL', 'type': 'education', 'lineage': ['https://openalex.org/I4210111138']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'René H. Medema', 'raw_affiliation_strings': ['Division of Molecular Biology, H8, The Netherlands Cancer Institute, Amsterdam, The Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Division of Molecular Biology, H8, The Netherlands Cancer Institute, Amsterdam, The Netherlands', 'institution_ids': ['https://openalex.org/I2898336195', 'https://openalex.org/I4210111138']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5033711163', 'display_name': 'Boudewijn Burgering', 'orcid': 'https://orcid.org/0000-0002-4044-9596'}, 'institutions': [{'id': 'https://openalex.org/I3018483916', 'display_name': 'University Medical Center Utrecht', 'ror': 'https://ror.org/0575yy874', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I3018483916']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Boudewijn M. T. Burgering', 'raw_affiliation_strings': ['Department of Physiological Chemistry, University Medical Center Utrecht and Center for Biomedical Genetics, Utrecht, The Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Department of Physiological Chemistry, University Medical Center Utrecht and Center for Biomedical Genetics, Utrecht, The Netherlands', 'institution_ids': ['https://openalex.org/I3018483916']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 5, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 9750, 'currency': 'EUR', 'value_usd': 11690, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 16.232, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 1489, 'citation_normalized_percentile': {'value': 0.999975, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '419', 'issue': '6904', 'first_page': '316', 'last_page': '321'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12835', 'display_name': 'Regulation and Functions of FoxO Transcription Factors', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12835', 'display_name': 'Regulation and Functions of FoxO Transcription Factors', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10676', 'display_name': 'Molecular Mechanisms of Aging and Longevity', 'score': 0.9986, 'subfield': {'id': 'https://openalex.org/subfields/1302', 'display_name': 'Aging'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10014', 'display_name': 'Molecular Responses to Abiotic Stress in Plants', 'score': 0.9492, 'subfield': {'id': 'https://openalex.org/subfields/1110', 'display_name': 'Plant Science'}, 'field': {'id': 'https://openalex.org/fields/11', 'display_name': 'Agricultural and Biological Sciences'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/foxo3', 'display_name': 'FOXO3', 'score': 0.5954404}, {'id': 'https://openalex.org/keywords/foxo-transcription-factors', 'display_name': 'FoxO Transcription Factors', 'score': 0.546558}, {'id': 'https://openalex.org/keywords/oxidative-stress', 'display_name': 'Oxidative Stress', 'score': 0.532445}, {'id': 'https://openalex.org/keywords/foxo1', 'display_name': 'FOXO1', 'score': 0.4464537}], 'concepts': [{'id': 'https://openalex.org/C48349386', 'wikidata': 'https://www.wikidata.org/wiki/Q424361', 'display_name': 'Reactive oxygen species', 'level': 2, 'score': 0.74828005}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.7160096}, {'id': 'https://openalex.org/C86339819', 'wikidata': 'https://www.wikidata.org/wiki/Q407384', 'display_name': 'Transcription factor', 'level': 3, 'score': 0.70437264}, {'id': 'https://openalex.org/C2776151105', 'wikidata': 'https://www.wikidata.org/wiki/Q898814', 'display_name': 'Oxidative stress', 'level': 2, 'score': 0.6943974}, {'id': 'https://openalex.org/C75217442', 'wikidata': 'https://www.wikidata.org/wiki/Q423650', 'display_name': 'Protein kinase B', 'level': 3, 'score': 0.6854866}, {'id': 'https://openalex.org/C168003608', 'wikidata': 'https://www.wikidata.org/wiki/Q21101484', 'display_name': 'FOXO3', 'level': 4, 'score': 0.5954404}, {'id': 'https://openalex.org/C190283241', 'wikidata': 'https://www.wikidata.org/wiki/Q14599311', 'display_name': 'Apoptosis', 'level': 2, 'score': 0.5431262}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.53608525}, {'id': 'https://openalex.org/C31573885', 'wikidata': 'https://www.wikidata.org/wiki/Q304484', 'display_name': 'Programmed cell death', 'level': 3, 'score': 0.50919193}, {'id': 'https://openalex.org/C140149449', 'wikidata': 'https://www.wikidata.org/wiki/Q17928793', 'display_name': 'FOXO1', 'level': 4, 'score': 0.4464537}, {'id': 'https://openalex.org/C2775838275', 'wikidata': 'https://www.wikidata.org/wiki/Q410776', 'display_name': 'Superoxide dismutase', 'level': 3, 'score': 0.43147188}, {'id': 'https://openalex.org/C62478195', 'wikidata': 'https://www.wikidata.org/wiki/Q828130', 'display_name': 'Signal transduction', 'level': 2, 'score': 0.37671003}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.37054878}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.22580585}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.107536346}], 'mesh': [{'descriptor_ui': 'D004268', 'descriptor_name': 'DNA-Binding Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D018384', 'descriptor_name': 'Oxidative Stress', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D017346', 'descriptor_name': 'Protein Serine-Threonine Kinases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D013482', 'descriptor_name': 'Superoxide Dismutase', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': True}, {'descriptor_ui': 'D013482', 'descriptor_name': 'Superoxide Dismutase', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D014157', 'descriptor_name': 'Transcription Factors', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000975', 'descriptor_name': 'Antioxidants', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000975', 'descriptor_name': 'Antioxidants', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002470', 'descriptor_name': 'Cell Survival', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002843', 'descriptor_name': 'Chromatin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002843', 'descriptor_name': 'Chromatin', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D016895', 'descriptor_name': 'Culture Media, Serum-Free', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004268', 'descriptor_name': 'DNA-Binding Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004268', 'descriptor_name': 'DNA-Binding Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D004789', 'descriptor_name': 'Enzyme Activation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004789', 'descriptor_name': 'Enzyme Activation', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D004790', 'descriptor_name': 'Enzyme Induction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000071161', 'descriptor_name': 'Forkhead Box Protein O1', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051858', 'descriptor_name': 'Forkhead Transcription Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005947', 'descriptor_name': 'Glucose', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005947', 'descriptor_name': 'Glucose', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007328', 'descriptor_name': 'Insulin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007328', 'descriptor_name': 'Insulin', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D048031', 'descriptor_name': 'JNK Mitogen-Activated Protein Kinases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008136', 'descriptor_name': 'Longevity', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008136', 'descriptor_name': 'Longevity', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D020928', 'descriptor_name': 'Mitogen-Activated Protein Kinases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020928', 'descriptor_name': 'Mitogen-Activated Protein Kinases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D008954', 'descriptor_name': 'Models, Biological', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009154', 'descriptor_name': 'Mutation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009154', 'descriptor_name': 'Mutation', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D011401', 'descriptor_name': 'Promoter Regions, Genetic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011401', 'descriptor_name': 'Promoter Regions, Genetic', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D011518', 'descriptor_name': 'Proto-Oncogene Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011518', 'descriptor_name': 'Proto-Oncogene Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D051057', 'descriptor_name': 'Proto-Oncogene Proteins c-akt', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012333', 'descriptor_name': 'RNA, Messenger', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D012333', 'descriptor_name': 'RNA, Messenger', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012333', 'descriptor_name': 'RNA, Messenger', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D017382', 'descriptor_name': 'Reactive Oxygen Species', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017382', 'descriptor_name': 'Reactive Oxygen Species', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D013482', 'descriptor_name': 'Superoxide Dismutase', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D013482', 'descriptor_name': 'Superoxide Dismutase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014157', 'descriptor_name': 'Transcription Factors', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D014157', 'descriptor_name': 'Transcription Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014407', 'descriptor_name': 'Tumor Cells, Cultured', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 3, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1038/nature01036', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S137773608', 'display_name': 'Nature', 'issn_l': '0028-0836', 'issn': ['0028-0836', '1476-4687'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319908', 'host_organization_name': 'Nature Portfolio', 'host_organization_lineage': ['https://openalex.org/P4310319908', 'https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Nature Portfolio', 'Springer Nature'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://dspace.library.uu.nl/handle/1874/14139', 'pdf_url': 'https://dspace.library.uu.nl/bitstream/handle/1874/14139/9.Kops%202002%20pp%20316-321.pdf?sequence=1&isAllowed=y', 'source': {'id': 'https://openalex.org/S4306401843', 'display_name': 'Data Archiving and Networked Services (DANS)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1322597698', 'host_organization_name': 'Royal Netherlands Academy of Arts and Sciences', 'host_organization_lineage': ['https://openalex.org/I1322597698'], 'host_organization_lineage_names': ['Royal Netherlands Academy of Arts and Sciences'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/12239572', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://dspace.library.uu.nl/handle/1874/14139', 'pdf_url': 'https://dspace.library.uu.nl/bitstream/handle/1874/14139/9.Kops%202002%20pp%20316-321.pdf?sequence=1&isAllowed=y', 'source': {'id': 'https://openalex.org/S4306401843', 'display_name': 'Data Archiving and Networked Services (DANS)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1322597698', 'host_organization_name': 'Royal Netherlands Academy of Arts and Sciences', 'host_organization_lineage': ['https://openalex.org/I1322597698'], 'host_organization_lineage_names': ['Royal Netherlands Academy of Arts and Sciences'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/15', 'display_name': 'Life on land', 'score': 0.53}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 28, 'referenced_works': ['https://openalex.org/W1488431596', 'https://openalex.org/W1496668015', 'https://openalex.org/W1625966995', 'https://openalex.org/W1631908837', 'https://openalex.org/W1812816875', 'https://openalex.org/W1877188956', 'https://openalex.org/W1974279777', 'https://openalex.org/W1976050844', 'https://openalex.org/W1995933463', 'https://openalex.org/W2009619113', 'https://openalex.org/W2012326456', 'https://openalex.org/W2022416092', 'https://openalex.org/W2023973783', 'https://openalex.org/W2037872087', 'https://openalex.org/W2046623154', 'https://openalex.org/W2062390485', 'https://openalex.org/W2077180087', 'https://openalex.org/W2082798387', 'https://openalex.org/W2085569151', 'https://openalex.org/W2087085892', 'https://openalex.org/W2089663038', 'https://openalex.org/W2113007696', 'https://openalex.org/W2133792873', 'https://openalex.org/W2137035181', 'https://openalex.org/W2160547697', 'https://openalex.org/W2166525118', 'https://openalex.org/W2168330194', 'https://openalex.org/W4245378753'], 'related_works': ['https://openalex.org/W2780696213', 'https://openalex.org/W2732755739', 'https://openalex.org/W2591452418', 'https://openalex.org/W2312478218', 'https://openalex.org/W2146685672', 'https://openalex.org/W1997730267', 'https://openalex.org/W1994465213', 'https://openalex.org/W1976819292', 'https://openalex.org/W1972166807', 'https://openalex.org/W1971206408'], 'abstract_inverted_index': {'Reactive': [0], 'oxygen': [1, 57, 99, 149], 'species': [2, 100], 'are': [3, 49], 'required': [4], 'for': [5], 'cell': [6, 52], 'proliferation': [7], 'but': [8], 'can': [9], 'also': [10, 28, 181], 'induce': [11], 'apoptosis.': [12, 36], 'In': [13, 107], 'proliferating': [14], 'cells': [15, 34, 44, 75, 109], 'this': [16, 179], 'paradox': [17], 'is': [18, 40, 121, 156], 'solved': [19], 'by': [20, 55, 79, 104], 'the': [21, 63, 112, 132, 138, 144], 'activation': [22, 133, 140], 'of': [23, 84, 115, 126, 134, 141, 147, 162], 'protein': [24], 'kinase': [25], 'B': [26], '(PKB;': [27], 'known': [29, 70], 'as': [30, 71, 123], 'c-Akt),': [31], 'which': [32], 'protects': [33, 73], 'from': [35, 76, 97, 169], 'By': [37], 'contrast,': [38], 'it': [39], 'unknown': [41], 'how': [42], 'quiescent': [43, 74, 108], 'that': [45, 62, 110, 178], 'lack': [46, 111], 'PKB': [47, 127], 'activity': [48], 'protected': [50], 'against': [51], 'death': [53], 'induced': [54, 122], 'reactive': [56, 98, 148], 'species.': [58, 150], 'Here': [59], 'we': [60, 176], 'show': [61], 'PKB-regulated': [64], 'Forkhead': [65, 135, 163], 'transcription': [66, 136], 'factor': [67], 'FOXO3a': [68], '(also': [69], 'FKHR-L1)': [72], 'oxidative': [77, 154], 'stress': [78, 155], 'directly': [80], 'increasing': [81], 'their': [82], 'quantities': [83], 'manganese': [85], 'superoxide': [86], 'dismutase': [87], '(MnSOD)': [88], 'messenger': [89], 'RNA': [90], 'and': [91, 143, 175], 'protein.': [92], 'This': [93, 129], 'increase': [94], 'in': [95, 165, 172], 'protection': [96], 'antagonizes': [101], 'apoptosis': [102], 'caused': [103], 'glucose': [105], 'deprivation.': [106], 'protective': [113], 'mechanism': [114, 120, 130], 'PKB-mediated': [116], 'signalling,': [117], 'an': [118], 'alternative': [119], 'a': [124], 'consequence': [125], 'inactivity.': [128], 'entails': [131], 'factors,': [137], 'transcriptional': [139], 'MnSOD': [142], 'subsequent': [145], 'reduction': [146], 'Increased': [151], 'resistance': [152], 'to': [153, 183], 'associated': [157], 'with': [158], 'longevity.': [159], 'The': [160], 'model': [161, 180], 'involvement': [164], 'regulating': [166], 'longevity': [167], 'stems': [168], 'genetic': [170], 'analysis': [171], 'Caenorhabditis': [173], 'elegans,': [174], 'conclude': [177], 'extends': [182], 'mammalian': [184], 'systems.': [185]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2099364141', 'counts_by_year': [{'year': 2024, 'cited_by_count': 34}, {'year': 2023, 'cited_by_count': 45}, {'year': 2022, 'cited_by_count': 50}, {'year': 2021, 'cited_by_count': 78}, {'year': 2020, 'cited_by_count': 76}, {'year': 2019, 'cited_by_count': 59}, {'year': 2018, 'cited_by_count': 64}, {'year': 2017, 'cited_by_count': 90}, {'year': 2016, 'cited_by_count': 63}, {'year': 2015, 'cited_by_count': 80}, {'year': 2014, 'cited_by_count': 91}, {'year': 2013, 'cited_by_count': 100}, {'year': 2012, 'cited_by_count': 84}], 'updated_date': '2024-09-23T16:55:08.158573', 'created_date': '2016-06-24'}