The AcrAB-TolC Efflux Pump Contributes to Multidrug Resistance in the Nosocomial Pathogen <i>Enterobacter aerogenes</i>

Name: Work Video:
Duration: 3 min 30 s
Description: We identified the genes encoding the AcrA-AcrB-TolC efflux pump in Enterobacter aerogenes and constructed acrAB and tolC mutants from a multidrug-resistant isolate. Both derivatives were more susceptible to antibiotics than the parental strain. Sequence analysis and complementation experiments revealed that the multidrug-resistant isolate is an acrR mutant.
Elizabeth Pradel; Jean‐Marie Pagès
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