Publication Information

{'id': 'https://openalex.org/W2098685167', 'doi': 'https://doi.org/10.18632/oncotarget.422', 'title': 'Recent Developments in Targeting Carbonic Anhydrase IX for Cancer Therapeutics', 'display_name': 'Recent Developments in Targeting Carbonic Anhydrase IX for Cancer Therapeutics', 'publication_year': 2012, 'publication_date': '2012-01-28', 'ids': {'openalex': 'https://openalex.org/W2098685167', 'doi': 'https://doi.org/10.18632/oncotarget.422', 'mag': '2098685167', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/22289741', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/3292895'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.422', 'pdf_url': 'https://www.oncotarget.com/article/422/pdf/', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'https://www.oncotarget.com/article/422/pdf/', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5008627536', 'display_name': 'Paul C. McDonald', 'orcid': 'https://orcid.org/0000-0002-7238-2912'}, 'institutions': [{'id': 'https://openalex.org/I1289530486', 'display_name': 'BC Cancer Agency', 'ror': 'https://ror.org/03sfybe47', 'country_code': 'CA', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1289530486']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Paul C. McDonald', 'raw_affiliation_strings': ['Department of Integrative Oncology, BC Cancer Research Centre and BC Cancer Agency, Vancouver, BC, Canada'], 'affiliations': [{'raw_affiliation_string': 'Department of Integrative Oncology, BC Cancer Research Centre and BC Cancer Agency, Vancouver, BC, Canada', 'institution_ids': ['https://openalex.org/I1289530486']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5106509821', 'display_name': 'Jean‐Yves Winum', 'orcid': 'https://orcid.org/0000-0003-3197-3414'}, 'institutions': [{'id': 'https://openalex.org/I4210145258', 'display_name': 'Institut des Biomolécules Max Mousseron', 'ror': 'https://ror.org/05d1e6v30', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I11935315', 'https://openalex.org/I1294671590', 'https://openalex.org/I198415970', 'https://openalex.org/I19894307', 'https://openalex.org/I4210104607', 'https://openalex.org/I4210128300', 'https://openalex.org/I4210145258', 'https://openalex.org/I66456633']}, {'id': 'https://openalex.org/I11935315', 'display_name': 'École Nationale Supérieure de Chimie de Montpellier', 'ror': 'https://ror.org/03sgyqj04', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I11935315']}, {'id': 'https://openalex.org/I1294671590', 'display_name': 'Centre National de la Recherche Scientifique', 'ror': 'https://ror.org/02feahw73', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I1294671590']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Jean-Yves Winum', 'raw_affiliation_strings': ["Institut des Biomolécules Max Mousseron (IBMM), UMR 5247 CNRS-UM1-UM2, Bâtiment de Recherche Max Mousseron, Ecole Nationale Supérieure de Chimie de Montpellier, 8 rue de l'Ecole Normale, 34296 Montpellier Cedex, France"], 'affiliations': [{'raw_affiliation_string': "Institut des Biomolécules Max Mousseron (IBMM), UMR 5247 CNRS-UM1-UM2, Bâtiment de Recherche Max Mousseron, Ecole Nationale Supérieure de Chimie de Montpellier, 8 rue de l'Ecole Normale, 34296 Montpellier Cedex, France", 'institution_ids': ['https://openalex.org/I4210145258', 'https://openalex.org/I11935315', 'https://openalex.org/I1294671590']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5035013697', 'display_name': 'Claudiu T. Supuran', 'orcid': 'https://orcid.org/0000-0003-4262-0323'}, 'institutions': [{'id': 'https://openalex.org/I45084792', 'display_name': 'University of Florence', 'ror': 'https://ror.org/04jr1s763', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I45084792']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Claudiu T. Supuran', 'raw_affiliation_strings': ['Laboritario di Chimica Bioinorganica, Universita degli Studi di Firenze, Italy'], 'affiliations': [{'raw_affiliation_string': 'Laboritario di Chimica Bioinorganica, Universita degli Studi di Firenze, Italy', 'institution_ids': ['https://openalex.org/I45084792']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5026004030', 'display_name': 'Shoukat Dedhar', 'orcid': 'https://orcid.org/0000-0003-4355-1657'}, 'institutions': [{'id': 'https://openalex.org/I1289530486', 'display_name': 'BC Cancer Agency', 'ror': 'https://ror.org/03sfybe47', 'country_code': 'CA', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1289530486']}, {'id': 'https://openalex.org/I141945490', 'display_name': 'University of British Columbia', 'ror': 'https://ror.org/03rmrcq20', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I141945490']}], 'countries': ['CA'], 'is_corresponding': True, 'raw_author_name': 'Shoukat Dedhar', 'raw_affiliation_strings': ['Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, Canada', 'Department of Integrative Oncology, BC Cancer Research Centre and BC Cancer Agency, Vancouver, BC, Canada'], 'affiliations': [{'raw_affiliation_string': 'Department of Integrative Oncology, BC Cancer Research Centre and BC Cancer Agency, Vancouver, BC, Canada', 'institution_ids': ['https://openalex.org/I1289530486']}, {'raw_affiliation_string': 'Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, Canada', 'institution_ids': ['https://openalex.org/I141945490']}]}], 'institution_assertions': [], 'countries_distinct_count': 3, 'institutions_distinct_count': 6, 'corresponding_author_ids': ['https://openalex.org/A5026004030'], 'corresponding_institution_ids': ['https://openalex.org/I1289530486', 'https://openalex.org/I141945490'], 'apc_list': None, 'apc_paid': None, 'fwci': 4.532, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 395, 'citation_normalized_percentile': {'value': 0.999716, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '3', 'issue': '1', 'first_page': '84', 'last_page': '97'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12412', 'display_name': 'Enzyme function and inhibition', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12412', 'display_name': 'Enzyme function and inhibition', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12251', 'display_name': 'Synthesis and Catalytic Reactions', 'score': 0.9968, 'subfield': {'id': 'https://openalex.org/subfields/1605', 'display_name': 'Organic Chemistry'}, 'field': {'id': 'https://openalex.org/fields/16', 'display_name': 'Chemistry'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, {'id': 'https://openalex.org/T13253', 'display_name': 'Chemical Reactions and Mechanisms', 'score': 0.9842, 'subfield': {'id': 'https://openalex.org/subfields/1606', 'display_name': 'Physical and Theoretical Chemistry'}, 'field': {'id': 'https://openalex.org/fields/16', 'display_name': 'Chemistry'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}], 'keywords': [], 'concepts': [{'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.66449183}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.5312804}, {'id': 'https://openalex.org/C2775914622', 'wikidata': 'https://www.wikidata.org/wiki/Q284089', 'display_name': 'Carbonic anhydrase', 'level': 3, 'score': 0.48413715}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.47944155}, {'id': 'https://openalex.org/C60644358', 'wikidata': 'https://www.wikidata.org/wiki/Q128570', 'display_name': 'Bioinformatics', 'level': 1, 'score': 0.35985523}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.267374}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.19380769}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.17873204}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.12272757}], 'mesh': [{'descriptor_ui': 'D000951', 'descriptor_name': 'Antigens, Neoplasm', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D002256', 'descriptor_name': 'Carbonic Anhydrases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D008495', 'descriptor_name': 'Medical Oncology', 'qualifier_ui': 'Q000639', 'qualifier_name': 'trends', 'is_major_topic': True}, {'descriptor_ui': 'D058990', 'descriptor_name': 'Molecular Targeted Therapy', 'qualifier_ui': 'Q000379', 'qualifier_name': 'methods', 'is_major_topic': True}, {'descriptor_ui': 'D009369', 'descriptor_name': 'Neoplasms', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000911', 'descriptor_name': 'Antibodies, Monoclonal', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D000911', 'descriptor_name': 'Antibodies, Monoclonal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000951', 'descriptor_name': 'Antigens, Neoplasm', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D000951', 'descriptor_name': 'Antigens, Neoplasm', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D000951', 'descriptor_name': 'Antigens, Neoplasm', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D000951', 'descriptor_name': 'Antigens, Neoplasm', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': False}, {'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000071231', 'descriptor_name': 'Carbonic Anhydrase IX', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002256', 'descriptor_name': 'Carbonic Anhydrases', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D002256', 'descriptor_name': 'Carbonic Anhydrases', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D002256', 'descriptor_name': 'Carbonic Anhydrases', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D002256', 'descriptor_name': 'Carbonic Anhydrases', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D015971', 'descriptor_name': 'Gene Expression Regulation, Enzymologic', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D015971', 'descriptor_name': 'Gene Expression Regulation, Enzymologic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015972', 'descriptor_name': 'Gene Expression Regulation, Neoplastic', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D015972', 'descriptor_name': 'Gene Expression Regulation, Neoplastic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008495', 'descriptor_name': 'Medical Oncology', 'qualifier_ui': 'Q000379', 'qualifier_name': 'methods', 'is_major_topic': False}, {'descriptor_ui': 'D008495', 'descriptor_name': 'Medical Oncology', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D058990', 'descriptor_name': 'Molecular Targeted Therapy', 'qualifier_ui': 'Q000639', 'qualifier_name': 'trends', 'is_major_topic': False}, {'descriptor_ui': 'D058990', 'descriptor_name': 'Molecular Targeted Therapy', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009369', 'descriptor_name': 'Neoplasms', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D009369', 'descriptor_name': 'Neoplasms', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D009369', 'descriptor_name': 'Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011487', 'descriptor_name': 'Protein Conformation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 7, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.422', 'pdf_url': 'https://www.oncotarget.com/article/422/pdf/', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://hal.archives-ouvertes.fr/hal-00676865', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306402512', 'display_name': 'HAL (Le Centre pour la Communication Scientifique Directe)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1294671590', 'host_organization_name': 'Centre National de la Recherche Scientifique', 'host_organization_lineage': ['https://openalex.org/I1294671590'], 'host_organization_lineage_names': ['Centre National de la Recherche Scientifique'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://hal.science/hal-00676865', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306402512', 'display_name': 'HAL (Le Centre pour la Communication Scientifique Directe)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1294671590', 'host_organization_name': 'Centre National de la Recherche Scientifique', 'host_organization_lineage': ['https://openalex.org/I1294671590'], 'host_organization_lineage_names': ['Centre National de la Recherche Scientifique'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc3292895', 'pdf_url': 'https://europepmc.org/articles/pmc3292895?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3292895', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'http://hdl.handle.net/2158/776334', 'pdf_url': 'https://flore.unifi.it/bitstream/2158/776334/1/422-3129-6-PB.pdf', 'source': {'id': 'https://openalex.org/S4306402033', 'display_name': 'Florence Research (University of Florence)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I45084792', 'host_organization_name': 'University of Florence', 'host_organization_lineage': ['https://openalex.org/I45084792'], 'host_organization_lineage_names': ['University of Florence'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/22289741', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.422', 'pdf_url': 'https://www.oncotarget.com/article/422/pdf/', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 113, 'referenced_works': ['https://openalex.org/W1523913576', 'https://openalex.org/W1524887217', 'https://openalex.org/W1542699111', 'https://openalex.org/W1574156814', 'https://openalex.org/W1586738141', 'https://openalex.org/W1677979836', 'https://openalex.org/W1716376475', 'https://openalex.org/W1749279251', 'https://openalex.org/W1785947665', 'https://openalex.org/W1915777887', 'https://openalex.org/W1942004826', 'https://openalex.org/W1955565662', 'https://openalex.org/W1962692964', 'https://openalex.org/W1963701446', 'https://openalex.org/W1964543625', 'https://openalex.org/W1966373553', 'https://openalex.org/W1969947339', 'https://openalex.org/W1969994476', 'https://openalex.org/W1973469475', 'https://openalex.org/W1973647515', 'https://openalex.org/W1979083195', 'https://openalex.org/W1990248904', 'https://openalex.org/W1990331048', 'https://openalex.org/W1990391394', 'https://openalex.org/W1996039941', 'https://openalex.org/W1996400431', 'https://openalex.org/W1998382179', 'https://openalex.org/W2005096273', 'https://openalex.org/W2005973718', 'https://openalex.org/W2006175671', 'https://openalex.org/W2006809455', 'https://openalex.org/W2009926942', 'https://openalex.org/W2010137863', 'https://openalex.org/W2012130782', 'https://openalex.org/W2012980054', 'https://openalex.org/W2014695629', 'https://openalex.org/W2016853027', 'https://openalex.org/W2017256144', 'https://openalex.org/W2017382594', 'https://openalex.org/W2019602861', 'https://openalex.org/W2024903578', 'https://openalex.org/W2026411584', 'https://openalex.org/W2027356017', 'https://openalex.org/W2028855134', 'https://openalex.org/W2030858021', 'https://openalex.org/W2031501898', 'https://openalex.org/W2032947646', 'https://openalex.org/W2034937288', 'https://openalex.org/W2037128835', 'https://openalex.org/W2037534240', 'https://openalex.org/W2037908392', 'https://openalex.org/W2040154948', 'https://openalex.org/W2041853813', 'https://openalex.org/W2042075770', 'https://openalex.org/W2044486547', 'https://openalex.org/W2045119355', 'https://openalex.org/W2045132748', 'https://openalex.org/W2045359719', 'https://openalex.org/W2047178318', 'https://openalex.org/W2049898410', 'https://openalex.org/W2050434810', 'https://openalex.org/W2051349300', 'https://openalex.org/W2051920977', 'https://openalex.org/W2054884455', 'https://openalex.org/W2056979194', 'https://openalex.org/W2059572504', 'https://openalex.org/W2061368965', 'https://openalex.org/W2071264542', 'https://openalex.org/W2071335476', 'https://openalex.org/W2076069507', 'https://openalex.org/W2078684128', 'https://openalex.org/W2083496553', 'https://openalex.org/W2084650789', 'https://openalex.org/W2084704553', 'https://openalex.org/W2088441277', 'https://openalex.org/W2088474340', 'https://openalex.org/W2089008773', 'https://openalex.org/W2089787007', 'https://openalex.org/W2090340029', 'https://openalex.org/W2094569859', 'https://openalex.org/W2096479061', 'https://openalex.org/W2098131572', 'https://openalex.org/W2101908524', 'https://openalex.org/W2108018051', 'https://openalex.org/W2113790366', 'https://openalex.org/W2114005496', 'https://openalex.org/W2115475680', 'https://openalex.org/W2116184358', 'https://openalex.org/W2116569478', 'https://openalex.org/W2117154421', 'https://openalex.org/W2122148781', 'https://openalex.org/W2127651945', 'https://openalex.org/W2130503287', 'https://openalex.org/W2130549804', 'https://openalex.org/W2130672532', 'https://openalex.org/W2130690650', 'https://openalex.org/W2133426152', 'https://openalex.org/W2135687519', 'https://openalex.org/W2141962705', 'https://openalex.org/W2143804648', 'https://openalex.org/W2149861830', 'https://openalex.org/W2156387230', 'https://openalex.org/W2158838439', 'https://openalex.org/W2159783793', 'https://openalex.org/W2165250160', 'https://openalex.org/W2167165074', 'https://openalex.org/W2170212327', 'https://openalex.org/W2196898337', 'https://openalex.org/W2312027414', 'https://openalex.org/W2329189826', 'https://openalex.org/W2330552545', 'https://openalex.org/W2465404022', 'https://openalex.org/W3100743833'], 'related_works': ['https://openalex.org/W4389568370', 'https://openalex.org/W3108674512', 'https://openalex.org/W3032375762', 'https://openalex.org/W3031052312', 'https://openalex.org/W2899084033', 'https://openalex.org/W2748952813', 'https://openalex.org/W2080531066', 'https://openalex.org/W1995515455', 'https://openalex.org/W1506200166', 'https://openalex.org/W1489783725'], 'abstract_inverted_index': {'Paul': [0], 'C.': [1], 'McDonald': [2], '1': [3, 17], ',': [4, 8], 'Jean-Yves': [5], 'Winum': [6], '2': [7, 33], 'Claudiu': [9], 'T.': [10], 'Supuran': [11], '3': [12, 63], 'and': [13, 26, 78, 133, 163, 174, 225, 237], 'Shoukat': [14, 109], 'Dedhar': [15], '1,4': [16], 'Department': [18, 75], 'of': [19, 76, 82, 137, 151, 155, 185, 197, 228, 243], 'Integrative': [20], 'Oncology,': [21], 'BC': [22, 27], 'Cancer': [23, 28], 'Research': [24], 'Centre': [25], 'Agency,': [29], 'Vancouver,': [30, 85], 'BC,': [31], 'Canada': [32, 86], 'Institut': [34], 'des': [35], 'Biomolécules': [36], 'Max': [37, 46], 'Mousseron': [38], '(IBMM),': [39], 'UMR': [40], '5247': [41], 'CNRS-UM1-UM2,': [42], 'Bâtiment': [43], 'de': [44, 50, 52, 56], 'Recherche': [45], 'Mousseron,': [47], 'EcoleNationale': [48], 'Supérieure': [49], 'Chimie': [51], 'Montpellier,': [53], '8': [54], 'rue': [55], "l'Ecole": [57], 'Normale,': [58], '34296': [59], 'Montpellier': [60], 'Cedex,': [61], 'France': [62], 'Laboritario': [64], 'di': [65, 71], 'Chimica': [66], 'Bioinorganica,': [67], 'Universita': [68], 'degli': [69], 'Studi': [70], 'Firenze,': [72], 'Italy': [73], '4': [74], 'Biochemistry': [77], 'Molecular': [79], 'Biology,': [80], 'University': [81], 'British': [83], 'Columbia,': [84], 'Received:': [87], 'January': [88, 92, 96], '4,': [89, 93], '2012;': [90, 94, 98], 'Accepted:': [91], 'Published:': [95], '28,': [97], 'Keywords:': [99], 'cancer,': [100], 'hypoxia,': [101], 'carbonic': [102], 'anhydrase': [103, 116], 'IX,': [104], 'metastasis,': [105], 'targeted': [106, 241], 'therapeutics': [107], 'Correspondence:': [108], 'Dedhar,': [110], 'email:': [111], '//': [112, 113], 'Abstract': [114], 'Carbonic': [115], 'IX': [117], '(CAIX)': [118], 'is': [119, 124, 134], 'a': [120, 135, 152, 239], 'hypoxia-inducible': [121], 'enzyme': [122], 'that': [123], 'overexpressed': [125], 'by': [126, 143, 213], 'cancer': [127, 214, 244], 'cells': [128, 145], 'from': [129], 'many': [130], 'tumor': [131, 171, 192, 223], 'types,': [132], 'component': [136], 'the': [138, 148, 178, 183], 'pH': [139, 167, 211], 'regulatory': [140], 'system': [141], 'invoked': [142], 'these': [144, 229], 'to': [146, 160, 220], 'combat': [147], 'deleterious': [149], 'effects': [150], 'high': [153], 'rate': [154], 'glycolytic': [156], 'metabolism.': [157], 'CAIX': [158, 198], 'functions': [159], 'help': [161], 'produce': [162], 'maintain': [164], 'an': [165, 186], 'intracellular': [166], '(pHi)': [168], 'favorable': [169], 'for': [170], 'cell': [172, 193], 'growth': [173, 224], 'survival,': [175], 'while': [176], 'at': [177], 'same': [179], 'time': [180], 'participating': [181], 'in': [182, 232], 'generation': [184], 'increasingly': [187], 'acidic': [188], 'extracellular': [189], 'space,': [190], 'facilitating': [191], 'invasiveness.': [194], 'Pharmacologic': [195], 'interference': [196], 'catalytic': [199], 'activity': [200], 'using': [201], 'monoclonal': [202], 'antibodies': [203], 'or': [204, 234], 'CAIX-specific': [205], 'small': [206], 'molecule': [207], 'inhibitors,': [208], 'consequently': [209], 'disrupting': [210], 'regulation': [212], 'cells,': [215], 'has': [216], 'been': [217], 'shown': [218], 'recently': [219], 'impair': [221], 'primary': [222], 'metastasis.': [226], 'Many': [227], 'agents': [230], 'are': [231], 'preclinical': [233], 'clinical': [235], 'development': [236], 'constitute': [238], 'novel,': [240], 'strategy': [242], 'therapy.': [245]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2098685167', 'counts_by_year': [{'year': 2024, 'cited_by_count': 14}, {'year': 2023, 'cited_by_count': 13}, {'year': 2022, 'cited_by_count': 19}, {'year': 2021, 'cited_by_count': 28}, {'year': 2020, 'cited_by_count': 35}, {'year': 2019, 'cited_by_count': 33}, {'year': 2018, 'cited_by_count': 41}, {'year': 2017, 'cited_by_count': 41}, {'year': 2016, 'cited_by_count': 42}, {'year': 2015, 'cited_by_count': 47}, {'year': 2014, 'cited_by_count': 41}, {'year': 2013, 'cited_by_count': 27}, {'year': 2012, 'cited_by_count': 12}], 'updated_date': '2024-12-28T02:46:10.519631', 'created_date': '2016-06-24'}