Abstract: Angewandte Chemie International EditionVolume 50, Issue 48 p. 11520-11524 Communication The Dynamic Structure of Filamentous Tau† Stefan Bibow, Stefan Bibow Department of NMR-based Structural Biology, Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, 37077 Göttingen (Germany)Search for more papers by this authorDr. Marco D. Mukrasch, Dr. Marco D. Mukrasch Department of NMR-based Structural Biology, Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, 37077 Göttingen (Germany)Search for more papers by this authorSubashchandrabose Chinnathambi, Subashchandrabose Chinnathambi Max Planck Unit for Structural Molecular Biology c/o DESY, Notkestrasse 85, 22607 Hamburg (Germany) DZNE, German Center for Neurodegenerative Diseases, and CAESAR, Ludwig-Erhard-Allee 2, 53175 Bonn (Germany)Search for more papers by this authorDr. Jacek Biernat, Dr. Jacek Biernat Max Planck Unit for Structural Molecular Biology c/o DESY, Notkestrasse 85, 22607 Hamburg (Germany) DZNE, German Center for Neurodegenerative Diseases, and CAESAR, Ludwig-Erhard-Allee 2, 53175 Bonn (Germany)Search for more papers by this authorProf. Dr. Christian Griesinger, Prof. Dr. Christian Griesinger Department of NMR-based Structural Biology, Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, 37077 Göttingen (Germany)Search for more papers by this authorProf. Dr. Eckhard Mandelkow, Prof. Dr. Eckhard Mandelkow Max Planck Unit for Structural Molecular Biology c/o DESY, Notkestrasse 85, 22607 Hamburg (Germany) DZNE, German Center for Neurodegenerative Diseases, and CAESAR, Ludwig-Erhard-Allee 2, 53175 Bonn (Germany)Search for more papers by this authorProf. Dr. Markus Zweckstetter, Corresponding Author Prof. Dr. Markus Zweckstetter [email protected] Department of NMR-based Structural Biology, Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, 37077 Göttingen (Germany)Department of NMR-based Structural Biology, Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, 37077 Göttingen (Germany)Search for more papers by this author Stefan Bibow, Stefan Bibow Department of NMR-based Structural Biology, Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, 37077 Göttingen (Germany)Search for more papers by this authorDr. Marco D. Mukrasch, Dr. Marco D. Mukrasch Department of NMR-based Structural Biology, Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, 37077 Göttingen (Germany)Search for more papers by this authorSubashchandrabose Chinnathambi, Subashchandrabose Chinnathambi Max Planck Unit for Structural Molecular Biology c/o DESY, Notkestrasse 85, 22607 Hamburg (Germany) DZNE, German Center for Neurodegenerative Diseases, and CAESAR, Ludwig-Erhard-Allee 2, 53175 Bonn (Germany)Search for more papers by this authorDr. Jacek Biernat, Dr. Jacek Biernat Max Planck Unit for Structural Molecular Biology c/o DESY, Notkestrasse 85, 22607 Hamburg (Germany) DZNE, German Center for Neurodegenerative Diseases, and CAESAR, Ludwig-Erhard-Allee 2, 53175 Bonn (Germany)Search for more papers by this authorProf. Dr. Christian Griesinger, Prof. Dr. Christian Griesinger Department of NMR-based Structural Biology, Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, 37077 Göttingen (Germany)Search for more papers by this authorProf. Dr. Eckhard Mandelkow, Prof. Dr. Eckhard Mandelkow Max Planck Unit for Structural Molecular Biology c/o DESY, Notkestrasse 85, 22607 Hamburg (Germany) DZNE, German Center for Neurodegenerative Diseases, and CAESAR, Ludwig-Erhard-Allee 2, 53175 Bonn (Germany)Search for more papers by this authorProf. Dr. Markus Zweckstetter, Corresponding Author Prof. Dr. Markus Zweckstetter [email protected] Department of NMR-based Structural Biology, Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, 37077 Göttingen (Germany)Department of NMR-based Structural Biology, Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, 37077 Göttingen (Germany)Search for more papers by this author First published: 11 October 2011 https://doi.org/10.1002/anie.201105493Citations: 66 † We thank Ilka Lindner for excellent technical support and the Johann-Wolfgang-Goethe University in Frankfurt (H. Schwalbe) for lending a 900 MHz HR-MAS probehead for some measurements. This work was supported by the Max Planck Society (to E.M. and C.G.) and through the DFG (Heisenberg Scholarship to M.Z. ZW 71/2-2, 3-2 and 7-1). Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat Graphical Abstract Getting inside a fuzzy coat: The dynamic structure of the “fuzzy coat”, N- and C-terminal sections around the core of the tau filament consists of over 200 amino acids, and has been characterized by NMR spectroscopy (see picture, model of the long range interactions). The results indicate how conformation specific antibodies bind to the tau protein (fibers of which are a characteristic symptom of Alzheimer disease). Supporting Information Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Filename Description anie_201105493_sm_miscellaneous_information.pdf886.1 KB miscellaneous_information Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. 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