Title: HEPATOPROTECTIVE EFFECT OF GENISTA QUADRIFLORA MUNBY EXTRACT AGAINST ETHANOL INDUCED TOXICITY
Abstract: Objective: Excessive ethanol intake induces severe tissue damage particularly in the liver through the generation of reactive oxygen species. This study was designed to examine the effect of n -butanol extract of Genista quadriflora for its protective potentials against ethanol induced toxicity. Methods: The effect of n -butanol extract of Genista quadriflora at a dose of 200 mg/kg was studied on ethanol induced hepatic damage (40 percent v/v, 3 g/kg per oral every 12 hours for 3 doses) in Wistar Albino rats. Serum transaminases, cholesterol, triglycerides, lipid peroxidation (MDA), reduced glutathione (GSH), glutathione peroxidase (GP X ) and catalase were estimated to access liver damage. A histological study was determined. Results: It was found that combined Genista quadriflora (200mg/kg) extract and ethanol treatment decreased significantly TBARS level and increased reduced glutathione, glutathione peroxidase, and catalase activities compared to the ethanol group (p<0.01). Treatment with ethanol altered liver architecture, whereas the extract pretreatment could be a protective factor for this organ. Conclusions: Results of in vivo experiments showed that the n -butanol extract of Genista quadriflora inhibited lipid peroxidation, protected the experimental animals from hepatic toxicity and maintained the levels of antioxidants enzymes. Key words: Genista quadriflora , ethanol, Antioxidant activities, lipid peroxidation, hepatoprotective effect.
Publication Year: 2014
Publication Date: 2014-02-01
Language: en
Type: article
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Cited By Count: 4
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