Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2098228975', 'doi': 'https://doi.org/10.1111/bph.12324', 'title': 'Orexin/hypocretin receptor signalling cascades', 'display_name': 'Orexin/hypocretin receptor signalling cascades', 'publication_year': 2013, 'publication_date': '2013-08-14', 'ids': {'openalex': 'https://openalex.org/W2098228975', 'doi': 'https://doi.org/10.1111/bph.12324', 'mag': '2098228975', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/23902572', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/3904254'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1111/bph.12324', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S55107261', 'display_name': 'British Journal of Pharmacology', 'issn_l': '0007-1188', 'issn': ['0007-1188', '1476-5381'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://europepmc.org/articles/pmc3904254?pdf=render', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5080765918', 'display_name': 'Jyrki P. Kukkonen', 'orcid': 'https://orcid.org/0000-0002-6989-1564'}, 'institutions': [{'id': 'https://openalex.org/I133731052', 'display_name': 'University of Helsinki', 'ror': 'https://ror.org/040af2s02', 'country_code': 'FI', 'type': 'education', 'lineage': ['https://openalex.org/I133731052']}], 'countries': ['FI'], 'is_corresponding': True, 'raw_author_name': 'J P Kukkonen', 'raw_affiliation_strings': ['Biochemistry and Cell Biology Department of Veterinary Biosciences University of Helsinki Helsinki Finland'], 'affiliations': [{'raw_affiliation_string': 'Biochemistry and Cell Biology Department of Veterinary Biosciences University of Helsinki Helsinki Finland', 'institution_ids': ['https://openalex.org/I133731052']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5020471017', 'display_name': 'Christopher S. Leonard', 'orcid': 'https://orcid.org/0000-0003-4414-1748'}, 'institutions': [{'id': 'https://openalex.org/I181190671', 'display_name': 'New York Medical College', 'ror': 'https://ror.org/03dkvy735', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I181190671']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'C S Leonard', 'raw_affiliation_strings': ['Department of Physiology New York Medical College Valhalla NY USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Physiology New York Medical College Valhalla NY USA', 'institution_ids': ['https://openalex.org/I181190671']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 2, 'corresponding_author_ids': ['https://openalex.org/A5080765918', 'https://openalex.org/A5020471017'], 'corresponding_institution_ids': ['https://openalex.org/I133731052', 'https://openalex.org/I181190671'], 'apc_list': {'value': 4330, 'currency': 'USD', 'value_usd': 4330, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 1.519, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 178, 'citation_normalized_percentile': {'value': 0.998182, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '171', 'issue': '2', 'first_page': '314', 'last_page': '331'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10985', 'display_name': "Sleep's Role in Memory Consolidation and Regulation", 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2805', 'display_name': 'Cognitive Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10985', 'display_name': "Sleep's Role in Memory Consolidation and Regulation", 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2805', 'display_name': 'Cognitive Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10342', 'display_name': 'Mammalian Circadian Rhythms and Physiology', 'score': 0.9977, 'subfield': {'id': 'https://openalex.org/subfields/2807', 'display_name': 'Endocrine and Autonomic Systems'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10489', 'display_name': 'Neuroendocrine Regulation of Appetite and Body Weight', 'score': 0.988, 'subfield': {'id': 'https://openalex.org/subfields/2807', 'display_name': 'Endocrine and Autonomic Systems'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/orexin-receptor', 'display_name': 'Orexin receptor', 'score': 0.5939458}, {'id': 'https://openalex.org/keywords/hypocretin', 'display_name': 'Hypocretin', 'score': 0.518457}, {'id': 'https://openalex.org/keywords/orexin', 'display_name': 'Orexin', 'score': 0.500843}], 'concepts': [{'id': 'https://openalex.org/C2779680196', 'wikidata': 'https://www.wikidata.org/wiki/Q410857', 'display_name': 'Orexin', 'level': 4, 'score': 0.8589609}, {'id': 'https://openalex.org/C2779605129', 'wikidata': 'https://www.wikidata.org/wiki/Q24785218', 'display_name': 'Orexin receptor', 'level': 5, 'score': 0.5939458}, {'id': 'https://openalex.org/C169760540', 'wikidata': 'https://www.wikidata.org/wiki/Q207011', 'display_name': 'Neuroscience', 'level': 1, 'score': 0.5681016}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.5188502}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.50067806}, {'id': 'https://openalex.org/C2779178603', 'wikidata': 'https://www.wikidata.org/wiki/Q356257', 'display_name': 'Adenylyl cyclase', 'level': 3, 'score': 0.47913453}, {'id': 'https://openalex.org/C135285700', 'wikidata': 'https://www.wikidata.org/wiki/Q38173', 'display_name': 'G protein-coupled receptor', 'level': 3, 'score': 0.4764745}, {'id': 'https://openalex.org/C98229152', 'wikidata': 'https://www.wikidata.org/wiki/Q1551556', 'display_name': 'Synaptic plasticity', 'level': 3, 'score': 0.46132368}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.4355784}, {'id': 'https://openalex.org/C197341189', 'wikidata': 'https://www.wikidata.org/wiki/Q863533', 'display_name': 'Postsynaptic potential', 'level': 3, 'score': 0.41885406}, {'id': 'https://openalex.org/C62478195', 'wikidata': 'https://www.wikidata.org/wiki/Q828130', 'display_name': 'Signal transduction', 'level': 2, 'score': 0.39620826}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.3238538}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.14988357}, {'id': 'https://openalex.org/C118303440', 'wikidata': 'https://www.wikidata.org/wiki/Q419968', 'display_name': 'Neuropeptide', 'level': 3, 'score': 0.1487734}], 'mesh': [{'descriptor_ui': 'D064446', 'descriptor_name': 'Orexin Receptors', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D000595', 'descriptor_name': 'Amino Acid Sequence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016923', 'descriptor_name': 'Cell Death', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016923', 'descriptor_name': 'Cell Death', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D063388', 'descriptor_name': 'Endocannabinoids', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D063388', 'descriptor_name': 'Endocannabinoids', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D019204', 'descriptor_name': 'GTP-Binding Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019204', 'descriptor_name': 'GTP-Binding Proteins', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008969', 'descriptor_name': 'Molecular Sequence Data', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009473', 'descriptor_name': 'Neuronal Plasticity', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009473', 'descriptor_name': 'Neuronal Plasticity', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D064446', 'descriptor_name': 'Orexin Receptors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D064446', 'descriptor_name': 'Orexin Receptors', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D043562', 'descriptor_name': 'Receptors, G-Protein-Coupled', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D043562', 'descriptor_name': 'Receptors, G-Protein-Coupled', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D013569', 'descriptor_name': 'Synapses', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013569', 'descriptor_name': 'Synapses', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D013569', 'descriptor_name': 'Synapses', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1111/bph.12324', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S55107261', 'display_name': 'British Journal of Pharmacology', 'issn_l': '0007-1188', 'issn': ['0007-1188', '1476-5381'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc3904254', 'pdf_url': 'https://europepmc.org/articles/pmc3904254?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3904254', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/23902572', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc3904254', 'pdf_url': 'https://europepmc.org/articles/pmc3904254?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being', 'score': 0.85}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 145, 'referenced_works': ['https://openalex.org/W1480481839', 'https://openalex.org/W1490311409', 'https://openalex.org/W1501722970', 'https://openalex.org/W1512830779', 'https://openalex.org/W1513722678', 'https://openalex.org/W1538147469', 'https://openalex.org/W1545745805', 'https://openalex.org/W1570315170', 'https://openalex.org/W1581771528', 'https://openalex.org/W1596260790', 'https://openalex.org/W1671441783', 'https://openalex.org/W1764472238', 'https://openalex.org/W1795823327', 'https://openalex.org/W1825581609', 'https://openalex.org/W1838211711', 'https://openalex.org/W1840777802', 'https://openalex.org/W1869368544', 'https://openalex.org/W1915837588', 'https://openalex.org/W1929232501', 'https://openalex.org/W1935851919', 'https://openalex.org/W1938652716', 'https://openalex.org/W1959892192', 'https://openalex.org/W1964628210', 'https://openalex.org/W1965663770', 'https://openalex.org/W1966330898', 'https://openalex.org/W1967305117', 'https://openalex.org/W1968973186', 'https://openalex.org/W1969581325', 'https://openalex.org/W1972076105', 'https://openalex.org/W1975089308', 'https://openalex.org/W1979632514', 'https://openalex.org/W1980858072', 'https://openalex.org/W1982487448', 'https://openalex.org/W1984311579', 'https://openalex.org/W1984429646', 'https://openalex.org/W1984694149', 'https://openalex.org/W1985579250', 'https://openalex.org/W1986447940', 'https://openalex.org/W1989051865', 'https://openalex.org/W1990331613', 'https://openalex.org/W1992054477', 'https://openalex.org/W2001652592', 'https://openalex.org/W2005150082', 'https://openalex.org/W2006526823', 'https://openalex.org/W2012771551', 'https://openalex.org/W2016202053', 'https://openalex.org/W2017200167', 'https://openalex.org/W2017384587', 'https://openalex.org/W2018017686', 'https://openalex.org/W2020790123', 'https://openalex.org/W2022180074', 'https://openalex.org/W2023396177', 'https://openalex.org/W2024400557', 'https://openalex.org/W2025350112', 'https://openalex.org/W2026363549', 'https://openalex.org/W2026494312', 'https://openalex.org/W2027721701', 'https://openalex.org/W2027740042', 'https://openalex.org/W2027749726', 'https://openalex.org/W2030204595', 'https://openalex.org/W2031806957', 'https://openalex.org/W2031872434', 'https://openalex.org/W2033547042', 'https://openalex.org/W2034485704', 'https://openalex.org/W2036325467', 'https://openalex.org/W2040700968', 'https://openalex.org/W2047308870', 'https://openalex.org/W2047385580', 'https://openalex.org/W2048888172', 'https://openalex.org/W2049464937', 'https://openalex.org/W2051408504', 'https://openalex.org/W2051726070', 'https://openalex.org/W2056260252', 'https://openalex.org/W2058489268', 'https://openalex.org/W2058549361', 'https://openalex.org/W2060534660', 'https://openalex.org/W2061617773', 'https://openalex.org/W2063961981', 'https://openalex.org/W2064600276', 'https://openalex.org/W2064897077', 'https://openalex.org/W2065214424', 'https://openalex.org/W2065389311', 'https://openalex.org/W2066205729', 'https://openalex.org/W2067025602', 'https://openalex.org/W2067176875', 'https://openalex.org/W2069066834', 'https://openalex.org/W2071475119', 'https://openalex.org/W2072346518', 'https://openalex.org/W2073373258', 'https://openalex.org/W2075744025', 'https://openalex.org/W2076308111', 'https://openalex.org/W2076918051', 'https://openalex.org/W2077755739', 'https://openalex.org/W2079523532', 'https://openalex.org/W2081304615', 'https://openalex.org/W2081900799', 'https://openalex.org/W2082775813', 'https://openalex.org/W2082915641', 'https://openalex.org/W2083977901', 'https://openalex.org/W2084248756', 'https://openalex.org/W2085477869', 'https://openalex.org/W2086264391', 'https://openalex.org/W2089781399', 'https://openalex.org/W2091074069', 'https://openalex.org/W2092696367', 'https://openalex.org/W2095252530', 'https://openalex.org/W2096310704', 'https://openalex.org/W2097824035', 'https://openalex.org/W2101674994', 'https://openalex.org/W2103848983', 'https://openalex.org/W2111986642', 'https://openalex.org/W2113755495', 'https://openalex.org/W2115902692', 'https://openalex.org/W2115941978', 'https://openalex.org/W2116562654', 'https://openalex.org/W2117906341', 'https://openalex.org/W2121147520', 'https://openalex.org/W2129629717', 'https://openalex.org/W2129763878', 'https://openalex.org/W2133533221', 'https://openalex.org/W2134067827', 'https://openalex.org/W2134333835', 'https://openalex.org/W2134555179', 'https://openalex.org/W2138098510', 'https://openalex.org/W2140166598', 'https://openalex.org/W2141239982', 'https://openalex.org/W2143557510', 'https://openalex.org/W2147050398', 'https://openalex.org/W2147196684', 'https://openalex.org/W2148115694', 'https://openalex.org/W2149753304', 'https://openalex.org/W2152211310', 'https://openalex.org/W2154467817', 'https://openalex.org/W2154675993', 'https://openalex.org/W2157584035', 'https://openalex.org/W2162054230', 'https://openalex.org/W2162670271', 'https://openalex.org/W2164675383', 'https://openalex.org/W2165488941', 'https://openalex.org/W2165583928', 'https://openalex.org/W2166672372', 'https://openalex.org/W2218580750', 'https://openalex.org/W2401837505', 'https://openalex.org/W4233595534', 'https://openalex.org/W4254797493'], 'related_works': ['https://openalex.org/W2793065418', 'https://openalex.org/W2770346233', 'https://openalex.org/W2766819319', 'https://openalex.org/W2517011724', 'https://openalex.org/W2370582537', 'https://openalex.org/W2131263310', 'https://openalex.org/W2080324686', 'https://openalex.org/W2056650895', 'https://openalex.org/W2043473760', 'https://openalex.org/W2017939085'], 'abstract_inverted_index': {'Orexin': [0], '(hypocretin)': [1], 'peptides': [2], 'and': [3, 15, 23, 43, 63, 103, 126, 140, 142, 167, 184, 205], 'their': [4, 64], 'two': [5], 'known': [6, 75], 'G-protein-coupled': [7], 'receptors': [8, 32, 53, 113, 151], 'play': [9], 'essential': [10], 'roles': [11], 'in': [12, 220, 244], 'sleep-wake': [13], 'control': [14], 'powerfully': [16], 'influence': [17, 28], 'other': [18, 128], 'systems': [19], 'regulating': [20], 'appetite/metabolism,': [21], 'stress': [22], 'reward.': [24], 'Consequently,': [25], 'drugs': [26], 'that': [27, 97], 'signalling': [29, 59, 79, 100, 189], 'by': [30, 154, 181, 194, 210], 'these': [31, 52, 195], 'may': [33], 'provide': [34], 'novel': [35], 'therapeutic': [36], 'opportunities': [37], 'for': [38], 'treating': [39], 'sleep': [40], 'disorders,': [41], 'obesity': [42], 'addiction.': [44], 'It': [45], 'is': [46, 73, 101, 104, 190], 'therefore': [47], 'critical': [48], 'to': [49, 116, 118, 231], 'understand': [50], 'how': [51], 'operate,': [54], 'the': [55, 58, 146, 177, 199, 242], 'nature': [56], 'of': [57, 120, 159, 164, 169, 179], 'cascades': [60], 'they': [61, 132, 173, 246], 'engage': [62], 'physiological': [65], 'targets.': [66], 'In': [67, 145], 'this': [68, 88], 'review,': [69], 'we': [70], 'evaluate': [71], 'what': [72], 'currently': [74], 'about': [76], 'orexin': [77, 98, 112, 150, 234], 'receptor': [78, 99, 235], 'cascades,': [80], 'while': [81, 224], 'a': [82], 'sister': [83], 'review': [84], '(Leonard': [85], '&': [86], 'Kukkonen,': [87], 'issue)': [89], 'focuses': [90], 'on': [91, 241], 'tissue-specific': [92], 'responses.': [93], 'The': [94], 'evidence': [95], 'suggests': [96], 'multifaceted': [102], 'substantially': [105], 'more': [106], 'diverse': [107], 'than': [108], 'originally': [109], 'thought.': [110], 'Indeed,': [111], 'are': [114, 218, 229, 247], 'able': [115], 'couple': [117], 'members': [119], 'at': [121], 'least': [122], 'three': [123], 'G-protein': [124], 'families': [125], 'possibly': [127], 'proteins,': [129], 'through': [130], 'which': [131, 245], 'regulate': [133], 'non-selective': [134, 160], 'cation': [135, 161], 'channels,': [136, 162], 'phospholipases,': [137], 'adenylyl': [138], 'cyclase,': [139], 'protein': [141], 'lipid': [143], 'kinases.': [144], 'central': [147], 'nervous': [148], 'system,': [149], 'produce': [152], 'neuroexcitation': [153], 'postsynaptic': [155], 'depolarization': [156], 'via': [157, 198, 206], 'activation': [158, 168], 'inhibition': [163], 'K⁺': [165], 'channels': [166], 'Na⁺/Ca²⁺': [170], 'exchange,': [171], 'but': [172], 'also': [174, 191], 'can': [175], 'stimulate': [176], 'release': [178, 203], 'neurotransmitters': [180], 'presynaptic': [182], 'actions': [183], 'modulate': [185], 'synaptic': [186], 'plasticity.': [187], 'Ca²⁺': [188, 207], 'prominently': [192], 'influenced': [193], 'receptors,': [196], 'both': [197], 'classical': [200], 'phospholipase': [201], 'C-Ca²⁺': [202], 'pathway': [204], 'influx,': [208], 'mediated': [209], 'several': [211], 'pathways.': [212], 'Upon': [213], 'longer-lasting': [214], 'stimulation,': [215], 'plastic': [216], 'effects': [217], 'observed': [219], 'some': [221], 'cell': [222], 'types,': [223], 'others,': [225], 'especially': [226], 'cancer': [227], 'cells,': [228], 'stimulated': [230], 'die.': [232], 'Thus,': [233], 'signals': [236], 'appear': [237], 'highly': [238], 'tunable,': [239], 'depending': [240], 'milieu': [243], 'operating.': [248]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2098228975', 'counts_by_year': [{'year': 2024, 'cited_by_count': 16}, {'year': 2023, 'cited_by_count': 16}, {'year': 2022, 'cited_by_count': 22}, {'year': 2021, 'cited_by_count': 14}, {'year': 2020, 'cited_by_count': 15}, {'year': 2019, 'cited_by_count': 16}, {'year': 2018, 'cited_by_count': 16}, {'year': 2017, 'cited_by_count': 21}, {'year': 2016, 'cited_by_count': 11}, {'year': 2015, 'cited_by_count': 14}, {'year': 2014, 'cited_by_count': 13}, {'year': 2013, 'cited_by_count': 4}], 'updated_date': '2024-09-17T16:13:05.461470', 'created_date': '2016-06-24'}