Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2098025594', 'doi': 'https://doi.org/10.1172/jci15693', 'title': 'Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency', 'display_name': 'Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency', 'publication_year': 2002, 'publication_date': '2002-10-15', 'ids': {'openalex': 'https://openalex.org/W2098025594', 'doi': 'https://doi.org/10.1172/jci15693', 'mag': '2098025594', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/12393845', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/150795'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1172/jci15693', 'pdf_url': 'http://www.jci.org/articles/view/15693/files/pdf', 'source': {'id': 'https://openalex.org/S114430552', 'display_name': 'Journal of Clinical Investigation', 'issn_l': '0021-9738', 'issn': ['0021-9738', '1558-8238'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320279', 'host_organization_name': 'American Society for Clinical Investigation', 'host_organization_lineage': ['https://openalex.org/P4310320279'], 'host_organization_lineage_names': ['American Society for Clinical Investigation'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'http://www.jci.org/articles/view/15693/files/pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5005912071', 'display_name': 'I. Sadaf Farooqi', 'orcid': 'https://orcid.org/0000-0001-7609-3504'}, 'institutions': [{'id': 'https://openalex.org/I241749', 'display_name': 'University of Cambridge', 'ror': 'https://ror.org/013meh722', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I241749']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'I. Sadaf Farooqi', 'raw_affiliation_strings': ["University Department of Medicine, Department of Clinical Biochemistry, Addenbrooke's Hospital, Cambridge, United Kingdom."], 'affiliations': [{'raw_affiliation_string': "University Department of Medicine, Department of Clinical Biochemistry, Addenbrooke's Hospital, Cambridge, United Kingdom.", 'institution_ids': ['https://openalex.org/I241749']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5084830170', 'display_name': 'Giuseppe Matarese', 'orcid': 'https://orcid.org/0000-0001-9429-0616'}, 'institutions': [{'id': 'https://openalex.org/I4210139435', 'display_name': 'Institute for Experimental Endocrinology and Oncology', 'ror': 'https://ror.org/04sn06036', 'country_code': 'IT', 'type': 'facility', 'lineage': ['https://openalex.org/I4210139435', 'https://openalex.org/I4210155236']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Giuseppe Matarese', 'raw_affiliation_strings': ['Centro di Endocrinologia e Oncologia Sperimentale-Consiglio Nazionale delle Ricerche (CEOS-CNR)'], 'affiliations': [{'raw_affiliation_string': 'Centro di Endocrinologia e Oncologia Sperimentale-Consiglio Nazionale delle Ricerche (CEOS-CNR)', 'institution_ids': ['https://openalex.org/I4210139435']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5030480250', 'display_name': 'Graham M. Lord', 'orcid': 'https://orcid.org/0000-0003-2069-4743'}, 'institutions': [{'id': 'https://openalex.org/I45129253', 'display_name': 'University College London', 'ror': 'https://ror.org/02jx3x895', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I124357947', 'https://openalex.org/I45129253']}, {'id': 'https://openalex.org/I124357947', 'display_name': 'University of London', 'ror': 'https://ror.org/04cw6st05', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I124357947']}, {'id': 'https://openalex.org/I4210160447', 'display_name': 'Universidad de Londres', 'ror': 'https://ror.org/054v4yq51', 'country_code': 'MX', 'type': 'education', 'lineage': ['https://openalex.org/I4210160447']}, {'id': 'https://openalex.org/I47508984', 'display_name': 'Imperial College London', 'ror': 'https://ror.org/041kmwe10', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I47508984']}], 'countries': ['GB', 'MX'], 'is_corresponding': False, 'raw_author_name': 'Graham M. Lord', 'raw_affiliation_strings': ['Imperial College London (University of London)'], 'affiliations': [{'raw_affiliation_string': 'Imperial College London (University of London)', 'institution_ids': ['https://openalex.org/I45129253', 'https://openalex.org/I124357947', 'https://openalex.org/I4210160447', 'https://openalex.org/I47508984']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5072252739', 'display_name': 'Julia M. Keogh', 'orcid': 'https://orcid.org/0000-0002-0399-4114'}, 'institutions': [{'id': 'https://openalex.org/I2802466933', 'display_name': 'Cambridge University Hospitals NHS Foundation Trust', 'ror': 'https://ror.org/04v54gj93', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2802466933']}, {'id': 'https://openalex.org/I4210156194', 'display_name': "Addenbrooke's Hospital", 'ror': 'https://ror.org/055vbxf86', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2802466933', 'https://openalex.org/I4210156194']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Julia M. Keogh', 'raw_affiliation_strings': ['Addenbrooke’s Hospital, Cambridge University Hospitals NHS Foundation Trust'], 'affiliations': [{'raw_affiliation_string': 'Addenbrooke’s Hospital, Cambridge University Hospitals NHS Foundation Trust', 'institution_ids': ['https://openalex.org/I2802466933', 'https://openalex.org/I4210156194']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5040234559', 'display_name': 'Elizabeth Lawrence', 'orcid': 'https://orcid.org/0000-0003-0934-6158'}, 'institutions': [{'id': 'https://openalex.org/I1320553840', 'display_name': 'Amgen (United States)', 'ror': 'https://ror.org/03g03ge92', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I1320553840']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Elizabeth Lawrence', 'raw_affiliation_strings': ['Amgen, Inc;'], 'affiliations': [{'raw_affiliation_string': 'Amgen, Inc;', 'institution_ids': ['https://openalex.org/I1320553840']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5087673329', 'display_name': 'Juliana Chizo Agwu', 'orcid': 'https://orcid.org/0000-0002-8593-187X'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Chizo Agwu', 'raw_affiliation_strings': ['Sandwell District General Hospital'], 'affiliations': [{'raw_affiliation_string': 'Sandwell District General Hospital', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5023707716', 'display_name': 'Veronica Sanna', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210139435', 'display_name': 'Institute for Experimental Endocrinology and Oncology', 'ror': 'https://ror.org/04sn06036', 'country_code': 'IT', 'type': 'facility', 'lineage': ['https://openalex.org/I4210139435', 'https://openalex.org/I4210155236']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Veronica Sanna', 'raw_affiliation_strings': ['Centro di Endocrinologia e Oncologia Sperimentale-Consiglio Nazionale delle Ricerche (CEOS-CNR)'], 'affiliations': [{'raw_affiliation_string': 'Centro di Endocrinologia e Oncologia Sperimentale-Consiglio Nazionale delle Ricerche (CEOS-CNR)', 'institution_ids': ['https://openalex.org/I4210139435']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5051779148', 'display_name': 'Susan A. Jebb', 'orcid': 'https://orcid.org/0000-0001-9190-2920'}, 'institutions': [{'id': 'https://openalex.org/I90344618', 'display_name': 'Medical Research Council', 'ror': 'https://ror.org/03x94j517', 'country_code': 'GB', 'type': 'government', 'lineage': ['https://openalex.org/I4210087105', 'https://openalex.org/I90344618']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Susan A. Jebb', 'raw_affiliation_strings': ['Medical Research Council Human Nutrition Research'], 'affiliations': [{'raw_affiliation_string': 'Medical Research Council Human Nutrition Research', 'institution_ids': ['https://openalex.org/I90344618']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5108003960', 'display_name': 'F Perna', 'orcid': 'https://orcid.org/0000-0001-5319-0977'}, 'institutions': [{'id': 'https://openalex.org/I71267560', 'display_name': 'University of Naples Federico II', 'ror': 'https://ror.org/05290cv24', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I71267560']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Francesco Perna', 'raw_affiliation_strings': ['Universita di Napoli (University of Naples Federico II)'], 'affiliations': [{'raw_affiliation_string': 'Universita di Napoli (University of Naples Federico II)', 'institution_ids': ['https://openalex.org/I71267560']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5077699502', 'display_name': 'Silvia Fontana', 'orcid': 'https://orcid.org/0000-0001-9589-7815'}, 'institutions': [{'id': 'https://openalex.org/I4210139435', 'display_name': 'Institute for Experimental Endocrinology and Oncology', 'ror': 'https://ror.org/04sn06036', 'country_code': 'IT', 'type': 'facility', 'lineage': ['https://openalex.org/I4210139435', 'https://openalex.org/I4210155236']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Silvia Fontana', 'raw_affiliation_strings': ['Centro di Endocrinologia e Oncologia Sperimentale-Consiglio Nazionale delle Ricerche (CEOS-CNR)'], 'affiliations': [{'raw_affiliation_string': 'Centro di Endocrinologia e Oncologia Sperimentale-Consiglio Nazionale delle Ricerche (CEOS-CNR)', 'institution_ids': ['https://openalex.org/I4210139435']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5108242111', 'display_name': 'Robert I. Lechler', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I47508984', 'display_name': 'Imperial College London', 'ror': 'https://ror.org/041kmwe10', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I47508984']}, {'id': 'https://openalex.org/I45129253', 'display_name': 'University College London', 'ror': 'https://ror.org/02jx3x895', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I124357947', 'https://openalex.org/I45129253']}, {'id': 'https://openalex.org/I124357947', 'display_name': 'University of London', 'ror': 'https://ror.org/04cw6st05', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I124357947']}, {'id': 'https://openalex.org/I4210160447', 'display_name': 'Universidad de Londres', 'ror': 'https://ror.org/054v4yq51', 'country_code': 'MX', 'type': 'education', 'lineage': ['https://openalex.org/I4210160447']}], 'countries': ['GB', 'MX'], 'is_corresponding': False, 'raw_author_name': 'Robert I. Lechler', 'raw_affiliation_strings': ['Imperial College London, University of London'], 'affiliations': [{'raw_affiliation_string': 'Imperial College London, University of London', 'institution_ids': ['https://openalex.org/I47508984', 'https://openalex.org/I45129253', 'https://openalex.org/I124357947', 'https://openalex.org/I4210160447']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5041247266', 'display_name': 'Alex M. DePaoli', 'orcid': 'https://orcid.org/0000-0001-6365-6099'}, 'institutions': [{'id': 'https://openalex.org/I1320553840', 'display_name': 'Amgen (United States)', 'ror': 'https://ror.org/03g03ge92', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I1320553840']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Alex M. DePaoli', 'raw_affiliation_strings': ['Amgen, Inc;'], 'affiliations': [{'raw_affiliation_string': 'Amgen, Inc;', 'institution_ids': ['https://openalex.org/I1320553840']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5013261212', 'display_name': 'Stephen O’Rahilly', 'orcid': 'https://orcid.org/0000-0003-2199-4449'}, 'institutions': [{'id': 'https://openalex.org/I4210156194', 'display_name': "Addenbrooke's Hospital", 'ror': 'https://ror.org/055vbxf86', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2802466933', 'https://openalex.org/I4210156194']}, {'id': 'https://openalex.org/I2802466933', 'display_name': 'Cambridge University Hospitals NHS Foundation Trust', 'ror': 'https://ror.org/04v54gj93', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2802466933']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Stephen O’Rahilly', 'raw_affiliation_strings': ['Addenbrooke’s Hospital, Cambridge University Hospitals NHS Foundation Trust'], 'affiliations': [{'raw_affiliation_string': 'Addenbrooke’s Hospital, Cambridge University Hospitals NHS Foundation Trust', 'institution_ids': ['https://openalex.org/I4210156194', 'https://openalex.org/I2802466933']}]}], 'institution_assertions': [], 'countries_distinct_count': 4, 'institutions_distinct_count': 11, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 5200, 'currency': 'USD', 'value_usd': 5200, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 16.046, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 1313, 'citation_normalized_percentile': {'value': 0.935879, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '110', 'issue': '8', 'first_page': '1093', 'last_page': '1103'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10489', 'display_name': 'Regulation of Appetite and Obesity', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2807', 'display_name': 'Endocrine and Autonomic Systems'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10489', 'display_name': 'Regulation of Appetite and Obesity', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2807', 'display_name': 'Endocrine and Autonomic Systems'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10528', 'display_name': 'Adipokines, Inflammation, and Metabolic Diseases', 'score': 0.9956, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11584', 'display_name': 'Biochemical Analysis and Sensing Techniques', 'score': 0.9941, 'subfield': {'id': 'https://openalex.org/subfields/2916', 'display_name': 'Nutrition and Dietetics'}, 'field': {'id': 'https://openalex.org/fields/29', 'display_name': 'Nursing'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/hyperinsulinemia', 'display_name': 'Hyperinsulinemia', 'score': 0.5543555}], 'concepts': [{'id': 'https://openalex.org/C2780613262', 'wikidata': 'https://www.wikidata.org/wiki/Q223739', 'display_name': 'Leptin', 'level': 3, 'score': 0.95053715}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.8433471}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.8267118}, {'id': 'https://openalex.org/C2780988686', 'wikidata': 'https://www.wikidata.org/wiki/Q14375936', 'display_name': 'Hyperinsulinemia', 'level': 4, 'score': 0.5543555}, {'id': 'https://openalex.org/C71315377', 'wikidata': 'https://www.wikidata.org/wiki/Q11364', 'display_name': 'Hormone', 'level': 2, 'score': 0.54907966}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.5353544}, {'id': 'https://openalex.org/C75908981', 'wikidata': 'https://www.wikidata.org/wiki/Q28578', 'display_name': 'Appetite', 'level': 2, 'score': 0.4647578}, {'id': 'https://openalex.org/C511355011', 'wikidata': 'https://www.wikidata.org/wiki/Q12174', 'display_name': 'Obesity', 'level': 2, 'score': 0.3648558}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.34844702}, {'id': 'https://openalex.org/C2777391703', 'wikidata': 'https://www.wikidata.org/wiki/Q1053470', 'display_name': 'Insulin resistance', 'level': 3, 'score': 0.08790815}], 'mesh': [{'descriptor_ui': 'D020738', 'descriptor_name': 'Leptin', 'qualifier_ui': 'Q000172', 'qualifier_name': 'deficiency', 'is_major_topic': True}, {'descriptor_ui': 'D020738', 'descriptor_name': 'Leptin', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D009765', 'descriptor_name': 'Obesity', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D009765', 'descriptor_name': 'Obesity', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D013601', 'descriptor_name': 'T-Lymphocytes', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D013601', 'descriptor_name': 'T-Lymphocytes', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002648', 'descriptor_name': 'Child', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002675', 'descriptor_name': 'Child, Preschool', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004734', 'descriptor_name': 'Energy Metabolism', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004734', 'descriptor_name': 'Energy Metabolism', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020738', 'descriptor_name': 'Leptin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020738', 'descriptor_name': 'Leptin', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D008213', 'descriptor_name': 'Lymphocyte Activation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008213', 'descriptor_name': 'Lymphocyte Activation', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009490', 'descriptor_name': 'Neurosecretory Systems', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009490', 'descriptor_name': 'Neurosecretory Systems', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D009490', 'descriptor_name': 'Neurosecretory Systems', 'qualifier_ui': 'Q000503', 'qualifier_name': 'physiopathology', 'is_major_topic': False}, {'descriptor_ui': 'D009765', 'descriptor_name': 'Obesity', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009765', 'descriptor_name': 'Obesity', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D009765', 'descriptor_name': 'Obesity', 'qualifier_ui': 'Q000503', 'qualifier_name': 'physiopathology', 'is_major_topic': False}, {'descriptor_ui': 'D010641', 'descriptor_name': 'Phenotype', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011994', 'descriptor_name': 'Recombinant Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011994', 'descriptor_name': 'Recombinant Proteins', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D013601', 'descriptor_name': 'T-Lymphocytes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015431', 'descriptor_name': 'Weight Loss', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015431', 'descriptor_name': 'Weight Loss', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1172/jci15693', 'pdf_url': 'http://www.jci.org/articles/view/15693/files/pdf', 'source': {'id': 'https://openalex.org/S114430552', 'display_name': 'Journal of Clinical Investigation', 'issn_l': '0021-9738', 'issn': ['0021-9738', '1558-8238'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320279', 'host_organization_name': 'American Society for Clinical Investigation', 'host_organization_lineage': ['https://openalex.org/P4310320279'], 'host_organization_lineage_names': ['American Society for Clinical Investigation'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc150795', 'pdf_url': 'https://europepmc.org/articles/pmc150795?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC150795', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/12393845', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1172/jci15693', 'pdf_url': 'http://www.jci.org/articles/view/15693/files/pdf', 'source': {'id': 'https://openalex.org/S114430552', 'display_name': 'Journal of Clinical Investigation', 'issn_l': '0021-9738', 'issn': ['0021-9738', '1558-8238'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320279', 'host_organization_name': 'American Society for Clinical Investigation', 'host_organization_lineage': ['https://openalex.org/P4310320279'], 'host_organization_lineage_names': ['American Society for Clinical Investigation'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'score': 0.74, 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 51, 'referenced_works': ['https://openalex.org/W1512875938', 'https://openalex.org/W1590709474', 'https://openalex.org/W1639930240', 'https://openalex.org/W1644435722', 'https://openalex.org/W1913147314', 'https://openalex.org/W1964952037', 'https://openalex.org/W1972518048', 'https://openalex.org/W1986333814', 'https://openalex.org/W1991073470', 'https://openalex.org/W1992751653', 'https://openalex.org/W1995813398', 'https://openalex.org/W1996713062', 'https://openalex.org/W1998508489', 'https://openalex.org/W2008787696', 'https://openalex.org/W2013583119', 'https://openalex.org/W2014093920', 'https://openalex.org/W2014508988', 'https://openalex.org/W2025731911', 'https://openalex.org/W2044939881', 'https://openalex.org/W2051138072', 'https://openalex.org/W2053426841', 'https://openalex.org/W2055956383', 'https://openalex.org/W2059063316', 'https://openalex.org/W2060682066', 'https://openalex.org/W2084310603', 'https://openalex.org/W2091087465', 'https://openalex.org/W2109738877', 'https://openalex.org/W2114888892', 'https://openalex.org/W2116807562', 'https://openalex.org/W2116843182', 'https://openalex.org/W2119292158', 'https://openalex.org/W2119367457', 'https://openalex.org/W2122729366', 'https://openalex.org/W2128133965', 'https://openalex.org/W2139743744', 'https://openalex.org/W2141527633', 'https://openalex.org/W2162716270', 'https://openalex.org/W2165345254', 'https://openalex.org/W2282510573', 'https://openalex.org/W2319361543', 'https://openalex.org/W2337077327', 'https://openalex.org/W4232676809', 'https://openalex.org/W4236537514', 'https://openalex.org/W4242900151', 'https://openalex.org/W4243916202', 'https://openalex.org/W4244100988', 'https://openalex.org/W4246473359', 'https://openalex.org/W4246914324', 'https://openalex.org/W4253093097', 'https://openalex.org/W4299432388', 'https://openalex.org/W5184979'], 'related_works': ['https://openalex.org/W83859975', 'https://openalex.org/W4387337877', 'https://openalex.org/W4381378522', 'https://openalex.org/W3122113864', 'https://openalex.org/W2549472841', 'https://openalex.org/W2387166044', 'https://openalex.org/W2212975813', 'https://openalex.org/W2061765719', 'https://openalex.org/W1989654418', 'https://openalex.org/W181759444'], 'abstract_inverted_index': {'The': [0, 139], 'wide': [1], 'range': [2], 'of': [3, 24, 28, 39, 62, 116, 130, 142], 'phenotypic': [4, 155], 'abnormalities': [5, 156], 'seen': [6], 'in': [7, 31, 42, 54, 85, 91], 'the': [8, 22, 37, 153], 'leptin-deficient': [9], 'ob/ob': [10], 'mouse': [11], 'and': [12, 80, 88, 121, 126, 148], 'their': [13], 'reversibility': [14], 'by': [15, 134], 'leptin': [16, 65, 137, 145, 161], 'administration': [17, 141], 'provide': [18], 'compelling': [19], 'evidence': [20], 'for': [21, 66], 'existence': [23], 'multiple': [25, 154], 'physiological': [26], 'functions': [27], 'this': [29, 40], 'hormone': [30, 41, 94], 'rodents.': [32], 'In': [33], 'contrast,': [34], 'information': [35], 'regarding': [36], 'roles': [38], 'humans': [43], 'is': [44], 'limited.': [45], 'Three': [46], 'morbidly': [47], 'obese': [48], 'children,': [49], 'who': [50], 'were': [51, 56, 132], 'congenitally': [52], 'deficient': [53], 'leptin,': [55], 'treated': [57], 'with': [58, 71, 113, 158], 'daily': [59], 'subcutaneous': [60, 140], 'injections': [61], 'recombinant': [63, 135, 143], 'human': [64, 136, 144, 160], 'up': [67], 'to': [68], '4': [69], 'years': [70], 'sustained,': [72], 'beneficial': [73, 150], 'effects': [74, 100, 151], 'on': [75, 101, 152], 'appetite,': [76], 'fat': [77], 'mass,': [78], 'hyperinsulinemia,': [79], 'hyperlipidemia.': [81], 'Leptin': [82, 109], 'therapy': [83], 'resulted': [84], 'a': [86], 'rapid': [87], 'sustained': [89, 149], 'increase': [90], 'plasma': [92], 'thyroid': [93], 'levels': [95], 'and,': [96], 'through': [97], 'its': [98], 'age-dependent': [99], 'gonadotropin': [102], 'secretion,': [103], 'facilitated': [104], 'appropriately': [105], 'timed': [106], 'pubertal': [107], 'development.': [108], 'deficiency': [110], 'was': [111], 'associated': [112, 157], 'reduced': [114], 'numbers': [115], 'circulating': [117], 'CD4+': [118], 'T': [119, 123], 'cells': [120], 'impaired': [122], 'cell': [124], 'proliferation': [125], 'cytokine': [127], 'release,': [128], 'all': [129], 'which': [131], 'reversed': [133], 'administration.': [138], 'has': [146], 'major': [147], 'congenital': [159], 'deficiency.': [162]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2098025594', 'counts_by_year': [{'year': 2024, 'cited_by_count': 15}, {'year': 2023, 'cited_by_count': 19}, {'year': 2022, 'cited_by_count': 26}, {'year': 2021, 'cited_by_count': 44}, {'year': 2020, 'cited_by_count': 43}, {'year': 2019, 'cited_by_count': 34}, {'year': 2018, 'cited_by_count': 51}, {'year': 2017, 'cited_by_count': 55}, {'year': 2016, 'cited_by_count': 55}, {'year': 2015, 'cited_by_count': 70}, {'year': 2014, 'cited_by_count': 88}, {'year': 2013, 'cited_by_count': 85}, {'year': 2012, 'cited_by_count': 75}], 'updated_date': '2025-01-16T19:14:27.491309', 'created_date': '2016-06-24'}