Title: Catalytic asymmetric hydrogenation of aldehydes
Abstract:Racemic α-arylaldehydes provide the corresponding primary alcoholsvia dynamic kinetic resolution in excellent enantioselectivities and yields upon hydrogenation using a Noyori ruthenium catalyst; for ...Racemic α-arylaldehydes provide the corresponding primary alcoholsvia dynamic kinetic resolution in excellent enantioselectivities and yields upon hydrogenation using a Noyori ruthenium catalyst; for example, the biologically active (S)-enantiomer of the non-steroidal anti-inflammatory drug ibuprofen could be synthesized via catalytic enantioselective hydrogenation of aldehyde1f followed by oxidation with potassium permanganate in 76% isolated yield and 96 : 4 er.Read More
Publication Year: 2007
Publication Date: 2007-01-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
Access and Citation
Cited By Count: 38
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