Publication Information

{'id': 'https://openalex.org/W2097707410', 'doi': 'https://doi.org/10.1074/jbc.m203510200', 'title': 'Targeted Lysosome Disruptive Elements for Improvement of Parenchymal Liver Cell-specific Gene Delivery', 'display_name': 'Targeted Lysosome Disruptive Elements for Improvement of Parenchymal Liver Cell-specific Gene Delivery', 'publication_year': 2002, 'publication_date': '2002-11-01', 'ids': {'openalex': 'https://openalex.org/W2097707410', 'doi': 'https://doi.org/10.1074/jbc.m203510200', 'mag': '2097707410', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/12237290'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.m203510200', 'pdf_url': 'http://www.jbc.org/article/S0021925819331722/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'http://www.jbc.org/article/S0021925819331722/pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5029283214', 'display_name': 'Sabine M.W. van Rossenberg', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Sabine M.W. van Rossenberg', 'raw_affiliation_strings': ['Division of Biopharmaceutics, Leiden/Amsterdam Center for Drug Research and the'], 'affiliations': [{'raw_affiliation_string': 'Division of Biopharmaceutics, Leiden/Amsterdam Center for Drug Research and the', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5033500729', 'display_name': 'Karen Sliedregt‐Bol', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I121797337', 'display_name': 'Leiden University', 'ror': 'https://ror.org/027bh9e22', 'country_code': 'NL', 'type': 'education', 'lineage': ['https://openalex.org/I121797337']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Karen M. Sliedregt-Bol', 'raw_affiliation_strings': ['Leiden Institute of Chemistry, Gorlaeus Laboratories , Leiden University , P.O. Box 9502, 2300 RA, Leiden, The Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Leiden Institute of Chemistry, Gorlaeus Laboratories , Leiden University , P.O. Box 9502, 2300 RA, Leiden, The Netherlands', 'institution_ids': ['https://openalex.org/I121797337']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5046375428', 'display_name': 'Nico J. Meeuwenoord', 'orcid': 'https://orcid.org/0000-0002-9074-8527'}, 'institutions': [{'id': 'https://openalex.org/I121797337', 'display_name': 'Leiden University', 'ror': 'https://ror.org/027bh9e22', 'country_code': 'NL', 'type': 'education', 'lineage': ['https://openalex.org/I121797337']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Nico J. Meeuwenoord', 'raw_affiliation_strings': ['Leiden Institute of Chemistry, Gorlaeus Laboratories , Leiden University , P.O. Box 9502, 2300 RA, Leiden, The Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Leiden Institute of Chemistry, Gorlaeus Laboratories , Leiden University , P.O. Box 9502, 2300 RA, Leiden, The Netherlands', 'institution_ids': ['https://openalex.org/I121797337']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5024733637', 'display_name': 'Theo J.C. van Berkel', 'orcid': 'https://orcid.org/0000-0003-1548-440X'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Theo J.C. van Berkel', 'raw_affiliation_strings': ['Division of Biopharmaceutics, Leiden/Amsterdam Center for Drug Research and the'], 'affiliations': [{'raw_affiliation_string': 'Division of Biopharmaceutics, Leiden/Amsterdam Center for Drug Research and the', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5108217170', 'display_name': 'Jacques H. van Boom', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I121797337', 'display_name': 'Leiden University', 'ror': 'https://ror.org/027bh9e22', 'country_code': 'NL', 'type': 'education', 'lineage': ['https://openalex.org/I121797337']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Jacques H. van Boom', 'raw_affiliation_strings': ['Leiden Institute of Chemistry, Gorlaeus Laboratories , Leiden University , P.O. Box 9502, 2300 RA, Leiden, The Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Leiden Institute of Chemistry, Gorlaeus Laboratories , Leiden University , P.O. Box 9502, 2300 RA, Leiden, The Netherlands', 'institution_ids': ['https://openalex.org/I121797337']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5109996993', 'display_name': 'Gijs A. van der Marel', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I121797337', 'display_name': 'Leiden University', 'ror': 'https://ror.org/027bh9e22', 'country_code': 'NL', 'type': 'education', 'lineage': ['https://openalex.org/I121797337']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Gijs A. van der Marel', 'raw_affiliation_strings': ['Leiden Institute of Chemistry, Gorlaeus Laboratories , Leiden University , P.O. Box 9502, 2300 RA, Leiden, The Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Leiden Institute of Chemistry, Gorlaeus Laboratories , Leiden University , P.O. Box 9502, 2300 RA, Leiden, The Netherlands', 'institution_ids': ['https://openalex.org/I121797337']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5019598572', 'display_name': 'Erik A.L. Biessen', 'orcid': 'https://orcid.org/0000-0002-6454-8548'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Erik A.L. Biessen', 'raw_affiliation_strings': ['Division of Biopharmaceutics, Leiden/Amsterdam Center for Drug Research and the'], 'affiliations': [{'raw_affiliation_string': 'Division of Biopharmaceutics, Leiden/Amsterdam Center for Drug Research and the', 'institution_ids': []}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 2500, 'currency': 'USD', 'value_usd': 2500, 'provenance': 'doaj'}, 'apc_paid': {'value': 2500, 'currency': 'USD', 'value_usd': 2500, 'provenance': 'doaj'}, 'fwci': 1.242, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 42, 'citation_normalized_percentile': {'value': 0.798079, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 91, 'max': 92}, 'biblio': {'volume': '277', 'issue': '48', 'first_page': '45803', 'last_page': '45810'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10725', 'display_name': 'RNA Interference and Gene Delivery', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10725', 'display_name': 'RNA Interference and Gene Delivery', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10207', 'display_name': 'Advanced biosensing and bioanalysis techniques', 'score': 0.9968, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10294', 'display_name': 'Cell death mechanisms and regulation', 'score': 0.9949, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/asialoglycoprotein-receptor', 'display_name': 'Asialoglycoprotein receptor', 'score': 0.6953451}], 'concepts': [{'id': 'https://openalex.org/C2780216420', 'wikidata': 'https://www.wikidata.org/wiki/Q83330', 'display_name': 'Lysosome', 'level': 3, 'score': 0.81602585}, {'id': 'https://openalex.org/C102747710', 'wikidata': 'https://www.wikidata.org/wiki/Q824237', 'display_name': 'Endosome', 'level': 3, 'score': 0.7579701}, {'id': 'https://openalex.org/C54009773', 'wikidata': 'https://www.wikidata.org/wiki/Q1429031', 'display_name': 'Transfection', 'level': 3, 'score': 0.7396691}, {'id': 'https://openalex.org/C11569505', 'wikidata': 'https://www.wikidata.org/wiki/Q727265', 'display_name': 'Asialoglycoprotein receptor', 'level': 4, 'score': 0.6953451}, {'id': 'https://openalex.org/C185154212', 'wikidata': 'https://www.wikidata.org/wiki/Q410454', 'display_name': 'Liposome', 'level': 2, 'score': 0.63983625}, {'id': 'https://openalex.org/C135983454', 'wikidata': 'https://www.wikidata.org/wiki/Q2790163', 'display_name': 'Gene delivery', 'level': 4, 'score': 0.63847077}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.49812484}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.4881974}, {'id': 'https://openalex.org/C2776200302', 'wikidata': 'https://www.wikidata.org/wiki/Q827450', 'display_name': 'Hepatocyte', 'level': 3, 'score': 0.47492084}, {'id': 'https://openalex.org/C1491633281', 'wikidata': 'https://www.wikidata.org/wiki/Q7868', 'display_name': 'Cell', 'level': 2, 'score': 0.43334323}, {'id': 'https://openalex.org/C79879829', 'wikidata': 'https://www.wikidata.org/wiki/Q5571762', 'display_name': 'Intracellular', 'level': 2, 'score': 0.4159429}, {'id': 'https://openalex.org/C111599444', 'wikidata': 'https://www.wikidata.org/wiki/Q213901', 'display_name': 'Genetic enhancement', 'level': 3, 'score': 0.41590652}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.36415505}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.30330846}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.19241497}, {'id': 'https://openalex.org/C202751555', 'wikidata': 'https://www.wikidata.org/wiki/Q221681', 'display_name': 'In vitro', 'level': 2, 'score': 0.1265251}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D018014', 'descriptor_name': 'Gene Transfer Techniques', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D008099', 'descriptor_name': 'Liver', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D008247', 'descriptor_name': 'Lysosomes', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000595', 'descriptor_name': 'Amino Acid Sequence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D066298', 'descriptor_name': 'In Vitro Techniques', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008099', 'descriptor_name': 'Liver', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': False}, {'descriptor_ui': 'D008099', 'descriptor_name': 'Liver', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008247', 'descriptor_name': 'Lysosomes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008810', 'descriptor_name': 'Mice, Inbred C57BL', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008969', 'descriptor_name': 'Molecular Sequence Data', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 3, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.m203510200', 'pdf_url': 'http://www.jbc.org/article/S0021925819331722/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://hdl.handle.net/1887/50012', 'pdf_url': 'https://scholarlypublications.universiteitleiden.nl/access/item%3A2872109/view', 'source': {'id': 'https://openalex.org/S4306400850', 'display_name': 'Leiden Repository (Leiden University)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I121797337', 'host_organization_name': 'Leiden University', 'host_organization_lineage': ['https://openalex.org/I121797337'], 'host_organization_lineage_names': ['Leiden University'], 'type': 'repository'}, 'license': 'other-oa', 'license_id': 'https://openalex.org/licenses/other-oa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/12237290', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.m203510200', 'pdf_url': 'http://www.jbc.org/article/S0021925819331722/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.49, 'id': 'https://metadata.un.org/sdg/1', 'display_name': 'No poverty'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 48, 'referenced_works': ['https://openalex.org/W1490154674', 'https://openalex.org/W1967660067', 'https://openalex.org/W1974533156', 'https://openalex.org/W1977502221', 'https://openalex.org/W1985506288', 'https://openalex.org/W1988341178', 'https://openalex.org/W1997527618', 'https://openalex.org/W1997874619', 'https://openalex.org/W2003021187', 'https://openalex.org/W2019144805', 'https://openalex.org/W2022315792', 'https://openalex.org/W2023532191', 'https://openalex.org/W2026606185', 'https://openalex.org/W2033318412', 'https://openalex.org/W2036077010', 'https://openalex.org/W2037567771', 'https://openalex.org/W2040494128', 'https://openalex.org/W2043287922', 'https://openalex.org/W2043423501', 'https://openalex.org/W2044164984', 'https://openalex.org/W2044365536', 'https://openalex.org/W2045418359', 'https://openalex.org/W2051983470', 'https://openalex.org/W2052787476', 'https://openalex.org/W2055903997', 'https://openalex.org/W2061737632', 'https://openalex.org/W2063902820', 'https://openalex.org/W2072545910', 'https://openalex.org/W2073063218', 'https://openalex.org/W2073265167', 'https://openalex.org/W2073655835', 'https://openalex.org/W2085649019', 'https://openalex.org/W2086990820', 'https://openalex.org/W2087261487', 'https://openalex.org/W2089659785', 'https://openalex.org/W2108224709', 'https://openalex.org/W2109674113', 'https://openalex.org/W2130409467', 'https://openalex.org/W2135815696', 'https://openalex.org/W2141633691', 'https://openalex.org/W2147680256', 'https://openalex.org/W2151142281', 'https://openalex.org/W2159052309', 'https://openalex.org/W2166648967', 'https://openalex.org/W2327078538', 'https://openalex.org/W2330884341', 'https://openalex.org/W2419283783', 'https://openalex.org/W287472170'], 'related_works': ['https://openalex.org/W4226523202', 'https://openalex.org/W4225663912', 'https://openalex.org/W3200703942', 'https://openalex.org/W2414477400', 'https://openalex.org/W2166086043', 'https://openalex.org/W2155562884', 'https://openalex.org/W2103818266', 'https://openalex.org/W2082727438', 'https://openalex.org/W2068986215', 'https://openalex.org/W1822227842'], 'abstract_inverted_index': {'The': [0, 234, 468, 513, 1464, 1934, 2233, 2353, 2995, 3234, 3511, 3556, 4106], 'transfection': [1, 44, 153, 235, 278, 387, 763, 1200, 2746, 2836, 2844, 2903, 3324, 3806], 'ability': [2, 236, 2430], 'of': [3, 15, 25, 35, 117, 124, 237, 249, 259, 269, 351, 358, 470, 515, 528, 537, 569, 751, 765, 1064, 1201, 1247, 1325, 1334, 1350, 1365, 1567, 1785, 1798, 1810, 1866, 1892, 1921, 1938, 1946, 1954, 2254, 2284, 2297, 2334, 2357, 2371, 2383, 2391, 2393, 2408, 2421, 2431, 2445, 2464, 2476, 2504, 2523, 2535, 2596, 2618, 2627, 2748, 2787, 2814, 2822, 2869, 2952, 2960, 2990, 2998, 3000, 3048, 3058, 3129, 3150, 3172, 3178, 3221, 3229, 3260, 3268, 3326, 3355, 3508, 3513, 3558, 3571, 3580, 3612, 3794, 3808, 4108], 'nonviral': [4, 238, 473, 767, 1250, 1804, 2607, 2630, 3328, 3516, 3810], 'gene': [5, 157, 204, 239, 391, 438, 474, 484, 744, 768, 1251, 1805, 2608, 2624, 2631, 3329, 3492, 3517, 3527, 3787, 3811], 'therapy': [6, 240, 485, 3528], 'vehicles': [7, 241, 3331], 'is': [8, 242, 727, 1342, 1942, 2274, 2378, 2508, 2780, 2872, 2973, 2980, 3034, 3250, 3263, 3770], 'generally': [9, 243, 1085, 2685, 4129], 'hampered': [10, 244], 'by': [11, 97, 163, 245, 331, 397, 1368, 1807, 1924, 1931, 2288, 2380, 2458, 2461, 2783, 2791, 2874, 3041, 3108, 3245, 3444], 'untimely': [12, 246], 'lysosomal': [13, 39, 247, 273, 738, 2282, 3134, 3292, 3450, 3502, 3781], 'degradation': [14, 248], 'internalized': [16, 250], 'DNA.': [17, 251], 'In': [18, 63, 174, 191, 252, 297, 408, 425, 2883, 3256], 'this': [19, 130, 224, 253, 364, 458, 547, 1729, 1799, 2084, 2470, 2597, 2611, 2979, 3590], 'study': [20, 254, 1800, 2598], 'we': [21, 193, 255, 427, 1731, 1817, 2113, 2613, 2976, 3272, 3283], 'describe': [22, 256], 'the': [23, 33, 38, 43, 87, 102, 111, 133, 152, 181, 211, 257, 267, 272, 277, 321, 336, 345, 367, 386, 415, 445, 520, 523, 534, 540, 724, 730, 748, 752, 756, 762, 766, 1065, 1088, 1092, 1159, 1171, 1244, 1323, 1331, 1340, 1369, 1561, 1580, 1734, 1743, 1768, 1774, 1783, 1808, 1890, 1944, 1955, 1958, 2086, 2089, 2102, 2242, 2251, 2255, 2280, 2295, 2298, 2308, 2335, 2381, 2384, 2389, 2405, 2415, 2422, 2429, 2432, 2441, 2451, 2465, 2472, 2477, 2480, 2499, 2527, 2616, 2619, 2623, 2636, 2682, 2745, 2764, 2776, 2784, 2788, 2820, 2835, 2843, 2866, 2875, 2901, 2949, 2971, 2981, 2986, 3013, 3018, 3021, 3049, 3056, 3062, 3102, 3111, 3130, 3133, 3176, 3179, 3208, 3227, 3246, 3261, 3311, 3323, 3446, 3449, 3501, 3563, 3566, 3577, 3583, 3767, 3773, 3791, 3795, 3799, 3805, 3809, 4109, 4132, 4136], 'development': [24, 258, 469, 3512], 'a': [26, 47, 82, 137, 196, 226, 260, 281, 316, 371, 430, 460, 471, 740, 1105, 1351, 1357, 1362, 1471, 1478, 1576, 1739, 1814, 1861, 1971, 2097, 2110, 2331, 2602, 2740, 3025, 3165, 3275, 3285, 3295, 3456, 3514, 3783, 4149], 'targeted': [27, 179, 261, 413, 1326, 1472, 1759, 1811, 2603, 2789, 3286, 3509], 'lysosome': [28, 199, 262, 433, 771, 780, 837, 1829, 3140, 3814, 3823, 3880], 'disruptive': [29, 200, 263, 434, 772, 781, 838, 1830, 2321, 3815, 3824, 3881], 'element': [30, 201, 264, 435], 'to': [31, 60, 65, 81, 92, 150, 159, 167, 180, 206, 219, 265, 294, 299, 315, 326, 384, 393, 401, 414, 440, 453, 478, 539, 584, 588, 729, 755, 760, 1192, 1198, 1339, 1354, 1361, 1469, 1788, 1802, 1859, 1880, 2082, 2100, 2120, 2123, 2129, 2236, 2276, 2314, 2401, 2435, 2484, 2498, 2600, 2739, 2769, 2895, 2911, 3147, 3321, 3454, 3521, 3582, 3627, 3631, 3772, 3798, 3803], 'facilitate': [32, 266, 747, 2324, 3790], 'escape': [34, 268, 739, 3128, 3293, 3447, 3782], 'DNA': [36, 270, 516, 538, 587, 726, 754, 1335, 2666, 3131, 3559, 3581, 3630, 3769, 3797], 'from': [37, 271, 1070, 1174, 1481, 2396, 3132, 3448, 3506, 4114], 'compartment,': [40, 274], 'thus': [41, 275, 759, 3802], 'enhancing': [42, 276], 'efficacy,': [45, 279], 'in': [46, 170, 229, 280, 404, 463, 483, 546, 743, 1204, 1565, 1750, 1762, 1773, 1777, 1792, 1832, 1948, 1963, 1974, 2259, 2312, 2374, 2447, 2479, 2640, 2744, 2751, 2763, 2801, 2819, 2846, 2857, 2905, 2916, 2941, 2992, 3053, 3175, 3213, 3219, 3223, 3237, 3280, 3294, 3459, 3500, 3526, 3589, 3786], 'cell-specific': [48, 198, 282, 432], 'fashion.': [49, 283, 3297], 'Two': [50, 284, 1474], 'peptides': [51, 285, 580, 895, 1067, 1103, 1162, 1184, 1956, 1959, 2322, 2478, 2621, 3022, 3209, 3623, 3938, 4111, 4147], '(INF7': [52, 286], 'and': [53, 108, 146, 217, 287, 342, 380, 451, 526, 758, 1077, 1091, 1115, 1178, 1185, 1336, 1483, 1570, 1745, 1780, 1825, 1863, 1874, 1940, 1968, 2127, 2329, 2359, 2377, 2414, 2474, 2688, 2692, 2736, 2805, 2852, 2859, 2877, 2948, 3002, 3007, 3067, 3114, 3142, 3156, 3231, 3301, 3354, 3569, 3801, 4121, 4135, 4159], 'JTS-1)': [54, 288], 'were': [55, 148, 289, 382, 582, 1494, 2854, 3625], 'tested': [56, 290, 1819], 'for': [57, 79, 86, 291, 313, 320, 1490, 1579, 1742, 1758, 1827, 2105, 2411, 2491, 2526, 2532, 2605, 2678, 2782, 3278, 3358], 'their': [58, 292, 1828], 'capacity': [59, 293, 764, 1084, 1831, 3807, 4128], 'disrupt': [61, 295, 1881], 'liposomes.': [62, 119, 296, 353, 2265], 'contrast': [64, 298, 2313], 'JTS-1,': [66, 300, 1484], 'INF7': [67, 75, 145, 184, 301, 309, 379, 418, 1487, 1856, 1925, 1941, 1967, 2273, 2315, 2358, 2364, 2397, 2413, 2496, 2851, 2871, 2961, 3001, 3006, 3230, 3249], 'induced': [68, 115, 302, 349], 'rapid': [69, 303, 1862], 'cholesterol-independent': [70, 304, 1864], 'leakage': [71, 116, 305, 350, 1865, 1870, 1920, 1930, 2305, 2392, 2765, 2966, 3141, 3171], '(EC50,': [72, 306], '1.3': [73, 307], 'μm).': [74, 308, 2249], 'was': [76, 177, 185, 310, 411, 419, 1467, 1573, 1801, 1857, 1871, 1878, 2094, 2117, 2257, 2489, 2599, 2759, 2816, 2908, 2938], 'therefore': [77, 311], 'selected': [78, 312], 'coupling': [80, 314, 1349], 'high': [83, 214, 317, 448, 808, 865, 1740, 1747, 3851, 3908], 'affinity': [84, 318, 1741, 2503, 2522], 'ligand': [85, 319], 'asialoglycoprotein': [88, 322, 784, 841, 1581, 3827, 3884], 'receptor': [89, 323, 1582, 3059, 3064], '(ASGPr),': [90, 324, 1583], 'K(GalNAc)2,': [91, 325, 812, 869, 2115, 3855, 3912], 'im-': [93, 327], 'prove': [94, 328], 'its': [95, 329, 735, 1337, 2360, 3232, 3778], 'uptake': [96, 330, 1364, 2786, 2947, 3047, 3119, 3259], 'parenchymal': [98, 160, 207, 332, 394, 441, 1726, 1763, 1789, 2106, 2131, 2642, 2754, 2792, 2861, 2889, 2917, 3214], 'liver': [99, 161, 208, 333, 395, 442, 1727, 1775, 1790, 2107, 2130, 2643, 2793, 2890, 3215, 3258], 'cells.': [100, 334, 1764, 2108, 2286, 2755, 2794, 2862, 2994], 'Although': [101, 143, 335, 377, 1094, 1239, 3158, 4138], 'parent': [103, 337, 2243], 'peptide': [104, 338, 1480, 1564, 2103, 2244, 2434, 2488, 2638], 'disrupted': [105, 339, 2263], 'both': [106, 144, 340, 378, 2368, 2412, 3460], 'cholesterol-rich': [107, 341, 2375, 2448], '-poor': [109, 343], 'liposomes,': [110, 344, 1867, 2125], 'conjugate,': [112, 346], 'INF7-K(GalNAc)2,': [113, 347, 1737, 1766, 3100, 3289], 'only': [114, 165, 348, 399, 1928, 2262, 3024, 3491], 'cholesterol-poor': [118, 352, 1751, 1882, 1922, 2264], 'Given': [120, 354], 'that': [121, 132, 202, 355, 366, 436, 581, 1073, 1348, 1733, 1964, 2260, 2303, 2363, 2520, 2803, 2865, 2936, 2945, 2970, 2978, 3036, 3139, 3207, 3240, 3267, 3271, 3316, 3498, 3624, 4117], 'endosomal': [122, 141, 356, 375, 524, 1167, 3567], 'membranes': [123, 222, 357, 456, 1976, 2283, 2366, 2376], 'eukaryotic': [125, 359], 'cells': [126, 162, 209, 360, 396, 443, 1791, 2132, 2644, 2891, 2907, 2918, 2943], 'contain': [127, 361], '<5%': [128, 362], 'cholesterol,': [129, 363], 'implies': [131, 365], 'conjugate': [134, 225, 368, 459, 2234, 2256], 'will': [135, 369, 2079, 2878, 3126], 'display': [136, 370], 'higher': [138, 372, 1363, 2914, 3265], 'selectivity': [139, 373], 'toward': [140, 374], 'membranes.': [142, 376], 'INF7-K(GalNAc)2': [147, 176, 381, 410, 2446, 2459, 2536, 2737, 2767, 2815, 2839, 2937, 2953, 2991, 3125, 3317], 'found': [149, 383, 1858, 2910], 'increase': [151, 385, 2743], 'efficiency': [154, 388, 2626, 2747], 'on': [155, 389, 1087, 1249, 1725, 2279, 2307, 2622, 2635, 2834, 3101, 4131], 'polyplex-mediated': [156, 390], 'transfer': [158, 392, 536, 1252, 1784, 2625, 3330, 3579], '30-fold,': [164, 398, 2742], 'INF7-K(GalNAc)2appeared': [166, 400], 'do': [168, 402], 'so': [169, 403], 'an': [171, 405, 480, 1109, 1485, 1793, 2269, 2502, 2521, 2628, 3121, 3523, 4153], 'ASGPr-specific': [172, 406], 'manner.': [173, 407], 'mice,': [175, 409], 'specifically': [178, 412, 2278], 'liver,': [182, 416, 3247], 'whereas': [183, 417, 1868, 2829, 2850, 3248], 'distributed': [186, 420, 3251], 'evenly': [187, 421, 3252], 'over': [188, 422, 3253], 'various': [189, 423, 3254], 'organs.': [190, 424, 3255], 'summary,': [192, 426], 'have': [194, 428, 572, 889, 1188, 1242, 1346, 1818, 1970, 2518, 2614, 2879, 3023, 3273, 3615, 3932], 'prepared': [195, 429], 'nontoxic': [197, 431], 'improves': [203, 437, 1782], 'delivery': [205, 232, 439, 466, 475, 769, 1333, 1806, 2632, 3518, 3812], 'via': [210, 444, 2367, 3120], 'ASGPr.': [212, 446], 'Its': [213, 447, 3298], 'cell': [215, 449, 1371, 2899, 3180], 'specificity': [216, 450], 'preference': [218, 452], 'lyse': [220, 454], 'intracellular': [221, 455, 749, 1079, 3148, 3792, 4123], 'make': [223, 457], 'promising': [227, 461, 1563, 2091], 'lead': [228, 462, 3146], 'hepatocyte-specific': [230, 464, 3276], 'drug/gene': [231, 465], 'protocols.': [233, 467], 'viable': [472, 3515], 'system': [476, 3519], 'continues': [477, 3520], 'be': [479, 2080, 2121, 2237, 2268, 2292, 2485, 2530, 2676, 2770, 2799, 2912, 3010, 3039, 3106, 3319, 3455, 3522], 'important': [481, 544, 3217, 3524, 3587], 'theme': [482, 3525], '(1Niidome': [486, 1585, 3529], 'T.': [487, 495, 497, 501, 617, 619, 627, 631, 1586, 1594, 1596, 1600, 3530, 3538, 3540, 3544, 3660, 3662, 3670, 3674], 'Urakawa': [488, 1587, 3531], 'M.': [489, 629, 1030, 1258, 1264, 1305, 1443, 1445, 1453, 1588, 1680, 1682, 1690, 3333, 3335, 3343, 3425, 3469, 3471, 3532, 3672, 4073], 'Sato': [490, 1589, 3533], 'H.': [491, 503, 625, 1590, 1602, 2210, 2575, 3364, 3401, 3534, 3546, 3668], 'Takahara': [492, 1591, 3535], 'Y.': [493, 1451, 1592, 1688, 3187, 3341, 3536], 'Anai': [494, 1593, 3537], 'Hatakayama': [496, 1595, 3539], 'Wada': [498, 1597, 3541], 'A.': [499, 550, 615, 623, 653, 713, 1048, 1222, 1254, 1314, 1418, 1598, 1655, 2001, 2019, 2037, 2056, 2162, 2542, 3467, 3542, 3593, 3658, 3666, 3696, 3756, 4091], 'Hirayama': [500, 1599, 3543], 'Aoyagi': [502, 1601, 3545], 'Biomaterials.': [504, 1603, 3547], '2000;': [505, 670, 1380, 1456, 1553, 1604, 1693, 2064, 2927, 3086, 3346, 3482, 3548, 3713], '21:': [506, 1605, 3549], '1811-1819Crossref': [507, 1606, 3550], 'PubMed': [508, 562, 657, 673, 694, 717, 905, 947, 964, 994, 1018, 1038, 1058, 1136, 1153, 1214, 1234, 1271, 1295, 1318, 1383, 1401, 1437, 1459, 1538, 1607, 1620, 1638, 1674, 1696, 1989, 2008, 2026, 2046, 2072, 2187, 2228, 2348, 2567, 2709, 2729, 2930, 3089, 3200, 3349, 3419, 3439, 3485, 3551, 3605, 3700, 3716, 3737, 3760, 3948, 3990, 4007, 4037, 4061, 4081, 4101, 4180, 4197], 'Scopus': [509, 563, 610, 658, 674, 695, 718, 906, 948, 965, 995, 1019, 1039, 1059, 1137, 1154, 1215, 1235, 1272, 1319, 1384, 1402, 1438, 1460, 1539, 1556, 1608, 1621, 1639, 1675, 1697, 1721, 1990, 2009, 2027, 2047, 2073, 2153, 2188, 2229, 2349, 2568, 2710, 2730, 2931, 3090, 3201, 3350, 3420, 3440, 3486, 3552, 3606, 3653, 3701, 3717, 3738, 3761, 3949, 3991, 4008, 4038, 4062, 4082, 4102, 4181], '(50)': [510, 1609, 3553], 'Google': [511, 565, 612, 660, 676, 697, 720, 908, 929, 950, 967, 997, 1021, 1041, 1061, 1139, 1156, 1217, 1237, 1274, 1296, 1321, 1386, 1404, 1440, 1462, 1515, 1541, 1558, 1610, 1623, 1641, 1677, 1699, 1723, 1854, 1915, 1992, 2011, 2029, 2049, 2075, 2155, 2190, 2231, 2351, 2570, 2592, 2664, 2712, 2732, 2933, 3092, 3203, 3352, 3381, 3422, 3442, 3488, 3554, 3608, 3655, 3703, 3719, 3740, 3763, 3951, 3972, 3993, 4010, 4040, 4064, 4084, 4104, 4183], 'Scholar).': [512, 566, 721, 1157, 1238, 1463, 1559, 1855, 2076, 2232, 2352, 2665, 2733, 3204, 3489, 3555, 3609, 3764, 4105], 'packaging': [514, 3557], 'into': [517, 1108, 1117, 3012, 3560, 4152, 4161], 'compact': [518, 3561], 'particles,': [519, 3562], 'cellular': [521, 1075, 1332, 2806, 3564, 4119], 'uptake,': [522, 2828, 3565], 'escape,': [525, 3568], 'unpacking': [527, 3570], 'these': [529, 1102, 3159, 3173, 3572, 4146], 'particles': [530, 3573], 'as': [531, 533, 2271, 2404, 3098, 3574, 3576], 'well': [532, 3575], 'subsequent': [535, 3578], 'nucleus': [541, 757, 3584, 3800], 'are': [542, 1068, 1096, 1960, 2686, 2693, 2808, 2892, 2954, 3161, 3210, 3585, 4112, 4140], 'considered': [543, 3586], 'steps': [545, 3588], 'regard': [548, 3220, 3591], '(2Kichler': [549, 3592], 'Mechtler': [551, 1280, 3594], 'K.': [552, 1024, 1281, 1303, 1447, 1684, 2579, 3337, 3368, 3595, 4067], 'Behr': [553, 645, 3596, 3688], 'J.P.': [554, 646, 1547, 3597, 3689], 'Wagner': [555, 1284, 3598], 'E.': [556, 621, 1285, 1299, 1449, 1686, 2164, 2204, 2544, 3339, 3395, 3599, 3664], 'Bioconj.': [557, 668, 1013, 1033, 1378, 2223, 2724, 3414, 3600, 3711, 4056, 4076], 'Chem.': [558, 669, 985, 1014, 1034, 1288, 1379, 1396, 1433, 1633, 1670, 2063, 2178, 2224, 2558, 2725, 3415, 3430, 3601, 3712, 4028, 4057, 4077], '1997;': [559, 691, 944, 1133, 1718, 2150, 2726, 3602, 3734, 3987, 4177], '8:': [560, 1053, 2727, 3198, 3603, 4096], '213-221Crossref': [561, 3604], '(89)': [564, 3607], 'A': [567, 3610], 'number': [568, 3611], 'DNA-packaging': [570, 3613], 'compounds': [571, 3614], 'been': [573, 890, 1190, 3137, 3616, 3933], 'reported,': [574, 3617], 'including': [575, 893, 3153, 3618, 3936], 'cationic': [576, 2637, 3050, 3619], 'lipids,': [577, 3620], 'polymers': [578, 3621], 'and/or': [579, 1165, 3622], 'designed': [583, 1489, 2275, 2490, 3626], 'self-assemble': [585, 3628], 'with': [586, 1164, 1575, 1889, 1927, 2096, 2428, 2501, 2668, 2885, 2958, 3017, 3110, 3164, 3629], 'form': [589, 2436, 3632], 'intermolecular': [590, 3633], 'complexes': [591, 1203, 2750, 3634], '(3Simoes': [592, 3635], 'S.': [593, 652, 712, 911, 1313, 1497, 1836, 1897, 2340, 2646, 3463, 3636, 3695, 3755, 3954], 'Slepushkin': [594, 3637], 'V.': [595, 704, 1528, 3070, 3638, 3747], 'Pires': [596, 3639], 'P.': [597, 644, 681, 1220, 1228, 2200, 3391, 3477, 3640, 3687, 3724], 'Gaspar': [598, 3641], 'R.': [599, 702, 1000, 1032, 1260, 3642, 3745, 4043, 4075], 'de': [600, 3643], 'Lima': [601, 3644], 'M.C.P.': [602, 3645], 'Duzgunes': [603, 3646], 'N.': [604, 976, 3427, 3647, 4019], 'Gene': [605, 900, 924, 1209, 1229, 1454, 1510, 1615, 1691, 1849, 1910, 2659, 2925, 3344, 3648, 3943, 3967], 'Ther.': [606, 901, 925, 1210, 1230, 1455, 1511, 1616, 1692, 1850, 1911, 2660, 2926, 3345, 3649, 3944, 3968], '1999;': [607, 636, 654, 961, 1150, 1231, 1434, 1671, 1986, 2023, 2043, 2589, 2706, 3378, 3650, 3679, 3697, 4004, 4194], '65:': [608, 3651], '1798-1807Crossref': [609, 3652], '(162)': [611, 3654], 'Scholar,': [613, 639, 661, 677, 698, 909, 930, 951, 968, 998, 1022, 1042, 1140, 1218, 1275, 1297, 1387, 1405, 1441, 1516, 1624, 1642, 1678, 1700, 1993, 2012, 2030, 2050, 2156, 2191, 2571, 2713, 3382, 3423, 3656, 3682, 3704, 3720, 3741, 3952, 3973, 3994, 4011, 4041, 4065, 4085, 4184], '4Watabe': [614, 3657], 'Yamaguchi': [616, 3659], 'Kawanishi': [618, 3661], 'Uchida': [620, 3663], 'Eguchi': [622, 3665], 'Mizuguchi': [624, 3667], 'Mayumi': [626, 3669], 'Nakanishi': [628, 3671], 'Hayakawa': [630, 3673], 'Biochim.': [632, 1265, 1550, 3675], 'Biophys.': [633, 1266, 1551, 3676], 'Acta': [634, 3677], 'Biomembr.': [635, 1267, 3678], '12:': [637, 3680], '1-2Google': [638, 3681], '5Zanta': [640, 3683], 'M.A.': [641, 897, 1206, 1612, 3684, 3940], 'Belguise': [642, 3685], 'Valladier': [643, 3686], 'Proc.': [647, 707, 1308, 3690, 3750], 'Natl.': [648, 708, 1309, 3691, 3751], 'Acad.': [649, 709, 1310, 3692, 3752], 'Sci.': [650, 710, 1311, 3693, 3753], 'U.': [651, 711, 1312, 3694, 3754], '96:': [655, 3698], '91-96Crossref': [656, 3699], '(669)': [659, 3702], '6Lim': [662, 3705], 'D.W.': [663, 1373, 3706], 'Yeom': [664, 1374, 3707], 'Y.I.': [665, 1375, 3708], 'Park': [666, 1376, 3709], 'T.G.': [667, 1377, 3710], '11:': [671, 1381, 1399, 1636, 3714], '688-695Crossref': [672, 1382, 3715], '(84)': [675, 1385, 3718], '7Morris': [678, 3721], 'M.C.': [679, 3722], 'Vidal': [680, 3723], 'Chaloin': [682, 3725], 'L.': [683, 1407, 1543, 1644, 2160, 2540, 3726], 'Heitz': [684, 3727], 'F.': [685, 934, 1123, 3728, 3977, 4167], 'Divita': [686, 3729], 'G.': [687, 1046, 3730, 4089], 'Nucleic': [688, 3731], 'Acids': [689, 3732], 'Res.': [690, 2705, 3733], '25:': [692, 3735], '2730-2736Crossref': [693, 3736], '(458)': [696, 3739], '8Torchilin': [699, 3742], 'V.P.': [700, 3743], 'Rammohan': [701, 3744], 'Weissig': [703, 3746], 'Levchenko': [705, 3748], 'T.S.': [706, 3749], '2001;': [714, 1398, 1635, 2179, 2559, 3197, 3757], '98:': [715, 3758], '8786-8791Crossref': [716, 3759], '(700)': [719, 3762], 'Upon': [722, 3765], 'internalization,': [723, 3766], 'packaged': [725, 753, 3768, 3796], 'transported': [728, 3771], 'lysosome,': [731, 3774], 'which': [732, 1328, 2116, 2372, 2507, 2825, 3290, 3452, 3775], 'subsequently': [733, 3115, 3776], 'degrades': [734, 3777], 'content,': [736, 2311, 3779], 'making': [737, 1754, 3780], 'key': [741, 3784], 'step': [742, 1816, 3785], 'delivery.': [745, 2493, 3788], 'To': [746, 2468, 2610, 3789], 'transport': [750, 3793], 'enhance': [761, 3804], 'vehicles,': [770, 3813], 'elements': [773, 1072, 3816, 4116], '(LDEs)': [774, 3817], '1The': [775, 832, 3818, 3875], 'abbreviations': [776, 833, 3819, 3876], 'used': [777, 834, 2114, 3820, 3877], 'for:': [778, 835, 3821, 3878], 'LDE(s),': [779, 836, 3822, 3879], 'element(s);': [782, 839, 3825, 3882], 'ASGPr,': [783, 840, 3826, 3883], 'receptor;': [785, 842, 3828, 3885], 'BHK,': [786, 843, 3829, 3886], 'baby': [787, 844, 3830, 3887], 'hamster': [788, 845, 3831, 3888], 'kidney;': [789, 846, 3832, 3889], 'Boc,': [790, 847, 3833, 3890], 't-butoxycarbonyl;': [791, 848, 3834, 3891], 'BOP,': [792, 849, 3835, 3892], 'benzotriazol-1-yloxy-tris(dimethylamino)phosphonium': [793, 850, 3836, 3893], 'hexafluorophosphate;': [794, 851, 3837, 3894], 'BSA,': [795, 852, 3838, 3895], 'bovine': [796, 853, 3839, 3896], 'serum': [797, 854, 3840, 3897], 'albumin;': [798, 855, 3841, 3898], 'CMV,': [799, 856, 3842, 3899], 'cytomegalovirus;': [800, 857, 3843, 3900], 'Fmoc,': [801, 858, 3844, 3901], 'N-(9-fluorenyl)methoxycarbonyl;': [802, 859, 3845, 3902], 'HA,': [803, 860, 1482, 3846, 3903], 'hemagglutinin;': [804, 861, 3847, 3904], 'HOBt,': [805, 862, 3848, 3905], 'hydroxybenzotriazole;': [806, 863, 3849, 3906], 'HPLC,': [807, 864, 3850, 3907], 'performance': [809, 866, 3852, 3909], 'liquid': [810, 818, 867, 875, 3853, 3861, 3910, 3918], 'chromatography;': [811, 868, 3854, 3911], 'di-N': [813, 870, 3856, 3913], 'α,N': [814, 871, 3857, 3914], 'ε-(5-(2-acetamido-2-deoxy-β-d-galactopyranosyloxy)pentanomido)': [815, 872, 3858, 3915], 'lysine;': [816, 873, 3859, 3916], 'LC-MS,': [817, 874, 3860, 3917], 'chromatography-mass': [819, 876, 3862, 3919], 'spectrometry;': [820, 877, 3863, 3920], 'Luc,': [821, 878, 3864, 3921], 'luciferase;': [822, 879, 3865, 3922], 'MALDI,': [823, 880, 3866, 3923], 'matrix-assisted': [824, 881, 3867, 3924], 'laser': [825, 882, 3868, 3925], 'desorption/ionization;': [826, 883, 3869, 3926], 'MTT,': [827, 884, 3870, 3927], '3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium': [828, 885, 3871, 3928], 'bromide;': [829, 886, 3872, 3929], 'TOF,': [830, 887, 3873, 3930], 'time-of-flight.': [831, 888, 3874, 3931], 'successfully': [891, 3934], 'applied,': [892, 3935], 'amphipathic': [894, 1066, 1110, 3937, 4110, 4154], '(9Wolfert': [896, 3939], 'Seymour': [898, 1207, 1613, 3941], 'L.W.': [899, 1208, 1614, 3942], '1998;': [902, 1052, 1211, 1268, 1535, 1617, 2005, 3945, 4095], '5:': [903, 1212, 1618, 3946], '409-414Crossref': [904, 1213, 1619, 3947], '(92)': [907, 1216, 1622, 3950], '10Gottschalk': [910, 3953], 'Sparrow': [912, 1498, 1529, 1837, 1898, 2647, 3955], 'J.T.': [913, 1499, 1530, 1838, 1899, 2648, 3956], 'Hauer': [914, 1500, 1839, 1900, 2649, 3957], 'J.': [915, 983, 1226, 1262, 1286, 1431, 1501, 1520, 1668, 1840, 1901, 2017, 2035, 2040, 2061, 2176, 2556, 2581, 2588, 2650, 2703, 3078, 3370, 3377, 3428, 3475, 3958, 4026], 'Mims': [916, 1502, 1841, 1902, 2651, 3959], 'M.P.': [917, 1503, 1842, 1903, 2652, 3960], 'Leland': [918, 1504, 1843, 1904, 2653, 3961], 'F.E.': [919, 1505, 1844, 1905, 2654, 3962], 'Woo': [920, 1506, 1845, 1906, 2655, 3963], 'S.L.C.': [921, 1507, 1846, 1907, 2656, 3964], 'Smith': [922, 1508, 1847, 1908, 2657, 3965], 'L.C.': [923, 1509, 1518, 1848, 1909, 2658, 3966], '1996;': [926, 986, 1015, 1512, 1851, 1912, 2661, 3431, 3969, 4029, 4058], '3:': [927, 1513, 1852, 1913, 2590, 2662, 3379, 3970], '448-457PubMed': [928, 1514, 1853, 1914, 2663, 3971], '11Wyman': [931, 3974], 'T.B.': [932, 1121, 3975, 4165], 'Nicol': [933, 1122, 3976, 4166], 'Zelphati': [935, 1124, 3978, 4168], 'O.': [936, 1125, 3979, 4169], 'Scaria': [937, 1126, 3980, 4170], 'P.V.': [938, 1127, 3981, 4171], 'Plank': [939, 1128, 1300, 3982, 4172], 'C.': [940, 1129, 1256, 1277, 1283, 1301, 3983, 4173], 'Szoka': [941, 1130, 2341, 3984, 4174], 'F.C.': [942, 1131, 2343, 3985, 4175], 'Biochemistry.': [943, 960, 1132, 1149, 1985, 2004, 2022, 2344, 3986, 4003, 4176, 4193], '36:': [945, 1134, 3988, 4178], '3008-3017Crossref': [946, 1135, 3989, 4179], '(421)': [949, 1138, 3992, 4182], '12Martin': [952, 1141, 3995, 4185], 'I.': [953, 1142, 1545, 1978, 1997, 2054, 3996, 4186], 'Pecheur': [954, 1143, 1979, 3997, 4187], 'E.I.': [955, 1144, 1980, 1995, 2014, 2032, 2052, 3998, 4188], 'Ruysschaert': [956, 1145, 1981, 1998, 2057, 3999, 4189], 'J.M.': [957, 1146, 1982, 1999, 2058, 4000, 4190], 'Hoekstra': [958, 1147, 1983, 2002, 2020, 2038, 2059, 4001, 4191], 'D.': [959, 1044, 1148, 1984, 2003, 2021, 2039, 2060, 4002, 4087, 4192], '38:': [962, 1151, 1987, 2024, 4005, 4195], '9337-9347Crossref': [963, 1152, 1988, 4006, 4196], '(21)': [966, 1155, 1991, 4009], '13Chowdhury': [969, 4012], 'N.R.': [970, 1010, 4013, 4053], 'Hays': [971, 1005, 4014, 4048], 'R.M.': [972, 1006, 4015, 4049], 'Bommineni': [973, 4016], 'V.R.': [974, 4017], 'Franki': [975, 4018], 'Chowdhury': [977, 1007, 1009, 4020, 4050, 4052], 'J.R.': [978, 1008, 4021, 4051], 'Wu': [979, 981, 1003, 1011, 4022, 4024, 4046, 4054], 'C.H.': [980, 1004, 1526, 4023, 4047], 'G.Y.': [982, 1012, 4025, 4055], 'Biol.': [984, 1051, 1287, 2042, 2062, 2177, 2557, 3085, 3429, 4027, 4094], '271:': [987, 3432, 4030], '2341-2346Abstract': [988, 4031], 'Full': [989, 991, 1055, 1292, 2067, 2069, 2182, 2184, 2562, 2564, 3434, 3436, 4032, 4034, 4098], 'Text': [990, 992, 1056, 1293, 2068, 2070, 2183, 2185, 2563, 2565, 3435, 3437, 4033, 4035, 4099], 'PDF': [993, 1057, 1294, 2071, 2186, 2566, 3438, 4036, 4100], '(67)': [996, 4039], '14Plourde': [999, 4042], 'Phillips': [1001, 4044], 'A.T.': [1002, 4045], '7:': [1016, 1457, 1694, 2928, 3347, 4059], '131-137Crossref': [1017, 4060], '(8)': [1020, 4063], '15Arar': [1023, 4066], 'Aubertin': [1025, 4068], 'A.M.': [1026, 4069], 'Roche': [1027, 4070], 'A.C.': [1028, 4071], 'Monsigny': [1029, 4072], 'Mayer': [1031, 4074], '1995;': [1035, 4078], '6:': [1036, 1232, 4079], '573-577Crossref': [1037, 4080], '(77)': [1040, 4083], '16Derossi': [1043, 4086], 'Chassaing': [1045, 4088], 'Prochiantz': [1047, 4090], 'Trends': [1049, 4092], 'Cell': [1050, 3194, 4093], '84-87Abstract': [1054, 4097], '(653)': [1060, 4103], 'Scholar).The': [1062, 2593, 2934], 'majority': [1063, 4107], 'derived': [1069, 2683, 4113], 'viral': [1071, 4115], 'promote': [1074, 3127, 3182, 4118], 'entry': [1076, 2999, 4120], 'correct': [1078, 4122], 'handling.': [1080, 4124], 'Their': [1081, 4125], 'membrane': [1082, 1195, 2336, 2482, 3044, 3143, 4126], 'permeabilizing': [1083, 4127], 'depends': [1086, 2306, 4130], 'lipid': [1089, 4133], 'composition': [1090, 4134], 'pH.': [1093, 4137], 'they': [1095, 3037, 4139], 'random': [1097, 4141], 'coil': [1098, 4142], 'at': [1099, 1112, 2294, 3030, 4143, 4156], 'pH': [1100, 1113, 3031, 3169, 4144, 4157], '7.0,': [1101, 4145], 'undergo': [1104, 4148], 'conformational': [1106, 4150], 'change': [1107, 4151], 'α-helix': [1111, 4155], '5.0': [1114, 4158], 'aggregate': [1116, 4160], 'multimeric': [1118, 4162], 'clusters': [1119, 4163], '(11Wyman': [1120, 4164], 'Subsequently,': [1158], 'clustered': [1160], 'helical': [1161], 'associate': [1163], 'penetrate': [1166], 'membranes,': [1168], 'thereby': [1169], 'destabilizing': [1170], 'membrane.': [1172], 'Apart': [1173], 'complete': [1175, 1919], 'virus': [1176], 'capsids': [1177], 'purified': [1179], 'capsid': [1180], 'proteins,': [1181], 'hemagglutinin': [1182], '(HA)-derived': [1183], 'synthetic': [1186, 2671], 'analogs': [1187], 'also': [1189, 2291, 2439, 2798, 3495], 'shown': [1191, 1347, 2118, 2519], 'induce': [1193, 1860], 'pH-sensitive': [1194, 1491], 'disruption,': [1196], 'leading': [1197], 'improved': [1199], 'DNA-polycation': [1202], 'vitro(9Wolfert': [1205], '17Schoen': [1219], 'Chonn': [1221], 'Cullis': [1223], 'P.R.': [1224], 'Wilschut': [1225], 'Scherrer': [1227], '823-832Crossref': [1233], '(85)': [1236], 'several': [1240], 'groups': [1241], 'studied': [1243, 1495], 'stimulatory': [1245, 2757, 2867, 2988, 3040, 3107], 'effect': [1246, 2617, 2758, 2833, 2868, 2989], 'LDEs': [1248], '(18Decout': [1253], 'Labeur': [1255], 'Goethals': [1257], 'Brasseur': [1259], 'Vandekerckhove': [1261], 'Rosseneu': [1263], '1372:': [1269], '102-116Crossref': [1270], '(15)': [1273], '19Plank': [1276], 'Oberhauser': [1278], 'B.': [1279, 1549], 'Koch': [1282], '1994;': [1289], '269:': [1290], '12918-12924Abstract': [1291], '20Wagner': [1298], 'Zatloukal': [1302], 'Cotten': [1304], 'Birnstiel': [1306], 'M.L.': [1307], '1992;': [1315], '89:': [1316], '7934-7938Crossref': [1317], '(656)': [1320], 'Scholar),': [1322, 1916, 3093], 'use': [1324, 1809, 3057, 3225, 3279], 'LDEs,': [1327], 'concomitantly': [1329], 'improve': [1330, 1803, 3322], 'translocation': [1338], 'nucleus,': [1341], 'rather': [1343], 'unexplored.Previous': [1344], 'studies': [1345, 1891, 2517], 'homing': [1352, 1577, 2098, 2111], 'device': [1353, 1578, 2099, 2112], 'liposomes': [1355, 1752, 1834, 1884, 1923, 2399, 2449], 'or': [1356, 1952, 2962, 3094, 3184], 'universal': [1358], 'carrier': [1359], 'leads': [1360], 'liposome-encapsulated': [1366], 'drugs': [1367, 2128, 3357, 3497], 'target': [1370, 3014], '(6Lim': [1372], '23Zhang': [1388, 1625], 'X.': [1389, 1626], 'Simmons': [1390, 1627], 'C.G.': [1391, 1628], 'Corey': [1392, 1629], 'D.R.': [1393, 1630], 'Bioorg.': [1394, 1631], 'Med.': [1395, 1432, 1632, 1669], 'Lett.': [1397, 1634], '1269-1272Crossref': [1400, 1637], '(45)': [1403, 1640], '24Sliedregt': [1406, 1643], 'Rensen': [1408, 1645], 'P.C.N.': [1409, 1646, 2158, 2538], 'Rump': [1410, 1647, 2576, 3365], 'E.T.': [1411, 1648, 2577, 3366], 'van': [1412, 1419, 1423, 1426, 1649, 1656, 1660, 1663, 1703, 1709, 1714, 2135, 2141, 2146, 2165, 2168, 2171, 2220, 2545, 2548, 2551, 2584, 3071, 3074, 3079, 3373, 3411], 'Santbrink': [1413, 1650], 'P.J.': [1414, 1651], 'Bijsterbosch': [1415, 1652, 2211, 2582, 3371, 3402], 'M.K.': [1416, 1653, 2212, 2583, 3372, 3403], 'Valentijn': [1417, 1654, 2205, 3396], 'der': [1420, 1657, 1704, 2136, 2202, 2214, 3393, 3405], 'Marel': [1421, 1658, 1705, 2137, 2215, 3406], 'G.A.': [1422, 1659, 1706, 2138, 2216, 3407], 'Boom': [1424, 1661, 1715, 2147, 2218, 3409], 'J.H.': [1425, 1662, 1716, 2148, 2219, 3410], 'Berkel': [1427, 1664, 1710, 2142, 2172, 2221, 2552, 2585, 3080, 3374, 3412], 'T.J.C.': [1428, 1665, 1711, 2143, 2173, 2553, 2586, 3081, 3375], 'Biessen': [1429, 1666, 1712, 2144, 2174, 2554], 'E.A.L.': [1430, 1667, 1713, 2145, 2175, 2193, 2555, 2573, 3362, 3384], '42:': [1435, 1672], '609-618Crossref': [1436, 1673], '(131)': [1439, 1676], '25Nishikawa': [1442, 1679], 'Yamauchi': [1444, 1681, 3334], 'Morimoto': [1446, 1683, 3336], 'Ishida': [1448, 1685, 3338], 'Takakura': [1450, 1687, 3340], 'Hashida': [1452, 1689, 3342], '548-555Crossref': [1458, 1695, 3348], '(153)': [1461, 1698, 3351], 'same': [1465], 'strategy': [1466], 'applied': [1468, 3320], 'generate': [1470], 'LDE.': [1473], 'fusogenic': [1475, 1760, 1822, 1936, 2240, 2293, 2433, 2620, 2812, 3028, 3287], 'peptides,': [1476, 1823], 'INF7,': [1477, 1560, 1770, 1826, 2287, 2734, 2775, 3269], '23-mer': [1479], 'artificial': [1486], 'mimic': [1488], 'helix': [1492], 'formation,': [1493], '(10Gottschalk': [1496, 1835, 1896, 2645], '21Smith': [1517], 'Duguid': [1519], 'Wadhwa': [1521], 'M.S.': [1522, 2715], 'Logan': [1523], 'M.J.': [1524], 'Tung': [1525], 'Edwards': [1527], 'Adv.': [1531, 3478], 'Drug': [1532, 3479], 'Del.': [1533, 3480], 'Rev.': [1534, 3481], '30:': [1536], '115-131Crossref': [1537], '(100)': [1540], 'Scholar,22Vaysse': [1542], 'Burgelin': [1544], 'Merlio': [1546], 'Arveiler': [1548], 'Acta.': [1552], '26:': [1554], '369-376Crossref': [1555], '(26)': [1557], 'most': [1562, 2090], 'terms': [1566], 'cholesterol': [1568, 2310, 2453], 'dependence': [1569], 'disruption': [1571, 2410, 3144], 'kinetics,': [1572], 'equipped': [1574, 2095], 'K(GalNAc)2': [1584, 2514], 'Scholar,9Wolfert': [1611], '26Valentijn': [1701], 'R.A.': [1702, 2134, 2338], 'Sliedregt': [1707, 2139, 2159, 2539], 'L.A.J.M.': [1708, 2140], 'Tetrahedron.': [1717, 2149], '53:': [1719, 2151], '759-770Crossref': [1720, 2152], '(48)': [1722, 2154], 'Scholar)': [1724, 3353, 3443], 'cells.In': [1728], 'report,': [1730], 'show': [1732, 3206], 'glycoconjugated': [1735, 2416, 2487, 2495, 2870], 'peptide,': [1736, 2092, 2790, 3288], 'displays': [1738], 'ASGPr': [1744, 2500, 2528, 2876], 'possesses': [1746], 'lytic': [1748, 2252, 2355, 2443, 2950, 3151], 'activity': [1749, 1761, 2253, 2444, 2779, 2813, 2951, 3029, 3303], 'only,': [1753], 'it': [1755, 2261, 2796, 3033, 3306], 'eminently': [1756], 'suitable': [1757], 'Moreover,': [1765, 1876, 2838], 'unlike': [1767], 'parental': [1769, 3312], 'accumulates': [1771], 'efficiently': [1772], 'after': [1776], 'vivo': [1778, 3224], 'administration': [1779], 'strongly': [1781], 'polyplexed': [1786, 2667], 'genes': [1787, 3360], 'ASGPr-dependent': [1794], 'fashion.DISCUSSIONThe': [1795], 'main': [1796], 'objective': [1797], 'LDEs.': [1812, 3510], 'As': [1813, 2109, 2964], 'first': [1815], 'two': [1820, 2510], 'HA-derived': [1821], 'JTS-1': [1824, 1877, 1932, 1939, 1969], 'calcein-laden': [1833], 'JTS-1-induced': [1869], 'much': [1872], 'slower': [1873], 'cholesterol-dependent.': [1875], 'unable': [1879], '(<20%)': [1883], 'completely.': [1885], 'These': [1886], 'findings': [1887], 'concur': [1888], 'Gottschalk': [1893], 'et': [1894], 'al.': [1895], 'who': [1917], 'showed': [1918, 2969], 'compared': [1926, 2957], 'partial': [1929], '(35%).': [1933], 'differential': [1935, 2354], 'profile': [1937, 2356, 3236, 3304], 'not': [1943, 2809, 2841, 3211], 'result': [1945], 'differences': [1947], 'net': [1949], 'negative': [1950], 'charge': [1951], 'hydrophobicity': [1953], 'because': [1957, 2450, 2681], 'very': [1961, 3026], 'similar': [1962], 'respect.': [1965], 'Possibly,': [1966], 'different': [1972], 'orientation': [1973, 2473], 'liposomal': [1975, 2452, 2481, 2804], '(12Martin': [1977], '37Pecheur': [1994], 'Martin': [1996, 2053], 'Bienvenue': [2000, 2018, 2036, 2055], '37:': [2006], '2361-2371Crossref': [2007], '(30)': [2010], '38Pecheur': [2013], 'Sainte': [2015, 2033], 'Marie': [2016, 2034], '364-373Crossref': [2025], '(28)': [2028], '39Pecheur': [2031], 'Membr.': [2041], '167:': [2044], '1-17Crossref': [2045], '(121)': [2048], '40Pecheur': [2051], '275:': [2065], '3936-3942Abstract': [2066], '(34)': [2074], 'Further': [2077], 'experiments': [2078], 'imperative': [2081], 'confirm': [2083, 2469], 'hypothesis.In': [2085], 'second': [2087], 'step,': [2088], 'INF-7,': [2093], 'render': [2101], 'specific': [2104], 'previously': [2119], 'able': [2122], 'redirect': [2124], 'lipoproteins,': [2126], '(26Valentijn': [2133], '32Rensen': [2157], 'Ferns': [2161, 2541], 'Kieviet': [2163, 2543], 'Rossenberg': [2166, 2546], 'S.M.W.': [2167, 2547], 'Leeuwen': [2169, 2549], 'S.H.': [2170, 2550], '276:': [2180, 2560], '37577-37584Abstract': [2181, 2561], '(174)': [2189, 2569], '41Biessen': [2192, 3383], 'Sliedregt-Bol': [2194, 3385], 'K.M.': [2195, 3386], "'T": [2196, 3387], 'Hoen': [2197, 3388], 'P.A.': [2198, 3389], 'Prince': [2199, 3390], 'Van': [2201, 2213, 2217, 3392, 3404, 3408], 'Bilt': [2203, 3394], 'A.R.': [2206, 3397], 'Meeuwenoord': [2207, 3398], 'N.J.': [2208, 3399], 'Princen': [2209, 3400], 'T.J.': [2222, 3413], '2002;': [2225, 3416], '13:': [2226, 3417], '295-302Crossref': [2227, 3418], '(32)': [2230, 3421], 'appeared': [2235, 2768], 'slightly': [2238], 'less': [2239, 2689, 2772, 2974], 'than': [2241, 2513, 2774, 2897, 2915, 3266, 3310], '(1.3': [2245], 'μm': [2246], 'versus': [2247], '6.1': [2248], 'However,': [2250, 2388, 2795], 'cholesterol-dependent': [2258, 3302], 'This': [2266, 2438, 2756, 2863], 'may': [2267, 2290, 2323, 2454, 2675, 3009, 3038, 3052, 3145], 'advantage': [2270], 'K(GalNAc)2-conjugated': [2272], 'act': [2277], 'cholesterol-deficient': [2281], 'ASGPr-expressing': [2285], 'contrast,': [2289], 'level': [2296], 'plasma': [2299], 'membrane.The': [2300], 'intriguing': [2301], 'observation': [2302, 2935], 'INF7-K(GalNAc)2-induced': [2304], 'liposome': [2309, 2409], 'alone,': [2316], 'prompted': [2317], 'further': [2318], 'study.': [2319], 'Lysosome': [2320], 'leakage,': [2325], 'through': [2326, 2330], 'pore': [2327, 2402, 2456], 'formation': [2328, 2403, 2457], 'detergent-like': [2332], 'solubilization': [2333], '(36Parente': [2337], 'Nir': [2339], 'Jr.,': [2342], '1990;': [2345], '29:': [2346], '8720-8728Crossref': [2347], '(302)': [2350], 'glycoconjugate': [2361, 2972, 3262], 'suggests': [2362], 'disrupts': [2365], 'pathways,': [2369], 'one': [2370], 'predominates': [2373], 'blocked': [2379], 'presence': [2382, 2821], 'bulky': [2385], 'glycoside': [2386, 2424, 2466], 'moiety.': [2387], 'lack': [2390], '125I-trypsin': [2394], 'inhibitor': [2395], '(glycoconjugate)-treated': [2398], 'points': [2400], 'major': [2406, 2982, 3457], 'pathway': [2407], 'INF7.': [2417, 3313], 'Rather,': [2418], 'steric': [2419, 2462], 'hindrance': [2420, 2463], 'exposed': [2423], 'group': [2425], 'might': [2426, 3504], 'interfere': [2427], 'pores.': [2437], 'explains': [2440], 'reduced': [2442, 2955, 2987], 'hamper': [2455], 'caused': [2460], 'group.': [2467], 'hypothesis,': [2471], 'distribution': [2475], 'need': [2483], 'addressed.The': [2486], 'ASGPr-directed': [2492], 'Indeed,': [2494], 'bound': [2497], '87': [2505, 2524], 'nm,': [2506], 'about': [2509], 'times': [2511], 'lower': [2512, 2777], 'itself.': [2515], 'Earlier': [2516], 'nm': [2525], 'should': [2529, 2797], 'sufficient': [2531], 'effective': [2533], 'targeting': [2534], '(32Rensen': [2537], '42Biessen': [2572], 'Vietsch': [2574, 3363], 'Fluiter': [2578, 3367], 'Kuiper': [2580, 3077, 3369], 'Biochem.': [2587, 3376], '783-792Crossref': [2591, 3380], 'final': [2594], 'goal': [2595], 'elaborate': [2601], 'LDE': [2604, 3277], 'improving': [2606], 'transfer.': [2609], 'end,': [2612], 'evaluated': [2615], 'established': [2629], 'protocol': [2633], 'based': [2634], 'K8': [2639], 'mouse': [2641, 2860], 'small': [2669], 'sized': [2670], 'oligocations': [2672], '(like': [2673], 'K8)': [2674], 'better': [2677], 'systemic': [2679], 'application': [2680, 3507], 'condensates': [2684], 'smaller': [2687], 'immunogenic,': [2690], 'nonaggregating,': [2691], 'readily': [2694], 'unpacked': [2695], 'intracellularly': [2696], '(43McKenzie': [2697], 'D.L.': [2698, 2721], 'Collard': [2699, 2716], 'W.T.': [2700, 2717], 'Rice': [2701, 2722], 'K.G.': [2702, 2723], 'Pept.': [2704], '54:': [2707], '311-318Crossref': [2708], '(69)': [2711], '44Wadhwa': [2714], 'Adami': [2718], 'R.C.': [2719], 'McKenzie': [2720], '81-88Crossref': [2728], '(200)': [2731], 'INF7-SGSC,': [2735], 'led': [2738], 'substantial,': [2741], 'K8·DNA': [2749, 3112], 'freshly': [2752], 'isolated': [2753], 'concentration-dependent.': [2760], 'Even': [2761], 'though': [2762], 'assay,': [2766], '6-fold': [2771, 3264], 'potent': [2773, 2856], 'intrinsic': [2778, 2902], 'compensated': [2781], 'enhanced': [2785], 'kept': [2800], 'mind': [2802], 'assays': [2807], 'fully': [2810], 'comparable.The': [2811], 'abolished': [2817], 'completely': [2818, 2939], 'excess': [2823], 'GalNAc,': [2824], 'blocks': [2826], 'ASGPr-mediated': [2827, 3122], 'GlcNAc': [2830], 'had': [2831], 'no': [2832], 'efficiency.': [2837], 'did': [2840], 'affect': [2842], 'yield': [2845], 'ASGPr-deficient': [2847], 'BHK': [2848, 2858, 2906, 2942, 2993], 'cells,': [2849, 3015], 'INF7-SGSC': [2853, 3003, 3008], 'equally': [2855], 'underlines': [2864], 'mediated': [2873], 'fewer': [2880], 'side': [2881], 'effects.': [2882], 'agreement': [2884], 'previous': [2886], 'studies,': [2887], 'primary': [2888], 'more': [2893, 3308], 'difficult': [2894], 'transfect': [2896], 'continuous': [2898], 'lines;': [2900], 'efficacy': [2904, 3325], 'indeed': [2909], '10–100-fold': [2913], '(45Beck': [2919], 'N.B.': [2920], 'Sidhu': [2921], 'J.S.': [2922], 'Omiecinski': [2923], 'C.J.': [2924], '1274-1283Crossref': [2929], '(54)': [2932], 'inactive': [2940], 'indicates': [2944], 'non-ASGPr-mediated': [2946], 'considerably': [2956], 'those': [2959], 'INF7-SGSC.': [2963], 'our': [2965], 'data': [2967], 'already': [2968], 'fusogenic,': [2975], 'propose': [2977], 'contributing': [2983], 'factor': [2984], 'underlying': [2985], 'actual': [2996], 'route': [2997], 'remains': [3004], 'unclear.': [3005], 'cointernalized': [3011], 'associated': [3016], 'polyplexes.': [3019], 'Because': [3020], 'weak': [3027], '7.4,': [3032], 'unlikely': [3035], 'facilitating': [3042, 3445], 'polyplex/plasma': [3043], 'fusion.': [3045], 'Cellular': [3046], 'polyplexes': [3051], 'turn': [3054], 'implicate': [3055], 'systems,': [3060], 'possibly': [3061], 'scavenger': [3063], 'class': [3065], 'B': [3066], 'CD36': [3068], '(46Terpstra': [3069], 'Amersfoort': [3072], 'E.S.': [3073], 'Velzen': [3075], 'A.G.': [3076], 'Arterioscler.': [3082], 'Thromb.': [3083], 'Vasc.': [3084], '20:': [3087], '1860-1872Crossref': [3088], '(118)': [3091], 'alternative': [3095], 'pathways': [3096], 'such': [3097], 'pinocytosis.': [3099], 'other': [3103, 3496], 'hand,': [3104], 'could': [3105, 3181, 3318], 'associating': [3109], 'complex': [3113, 3118], 'promoting': [3116], 'whole': [3117], 'pathway.': [3123], 'Intracellularly,': [3124], 'compartment.It': [3135], 'has': [3136], 'reported': [3138], 'release': [3149], 'enzymes': [3152, 3160, 3174], 'proteases,': [3154], 'nucleases,': [3155], 'lipases.': [3157], 'acid': [3162], 'hydrolases,': [3163], 'catalytic': [3166], 'optimum': [3167], 'near': [3168], '5.0,': [3170], 'cytoplasm': [3177], 'apoptosis': [3183], 'necrosis': [3185], '(47Zang': [3186], 'Beard': [3188], 'R.L.': [3189], 'Chandraratna': [3190], 'R.A.S.': [3191], 'Kang': [3192], 'J.X.': [3193], 'Death': [3195], 'Differ.': [3196], '477-485Crossref': [3199], '(113)': [3202], 'We': [3205, 3314], 'cytotoxic': [3212], 'cells.Another': [3216], 'issue': [3218], 'potential': [3222], 'involves': [3226], 'pharmacokinetics': [3228], 'glycoconjugate.': [3233], 'biodistribution': [3235], 'mice': [3238], 'shows': [3239], 'INF7-K(GalNAc)2is': [3241], 'preferentially': [3242], 'taken': [3243], 'up': [3244], 'fact,': [3257], 'indicating': [3270], 'developed': [3274], 'vivo.In': [3281], 'conclusion,': [3282], 'present': [3284], 'induces': [3291], 'receptor-dependent': [3296], 'favorable': [3299], 'pH-': [3300], 'makes': [3305], 'even': [3307], 'lysosome-specific': [3309], 'envision': [3315], 'hepatic': [3327, 3359], '(25Nishikawa': [3332], 'antisense': [3356], '(42Biessen': [3361], '48Sugano': [3424], 'Makino': [3426], '19080-19083Abstract': [3433], '(44)': [3441], 'pathway,': [3451], 'appears': [3453], 'drawback': [3458], 'therapies': [3461], '(49Akhtar': [3462], 'Hughes': [3464], 'M.D.': [3465], 'Khan': [3466], 'Bibby': [3468], 'Hussain': [3470], 'Nawaz': [3472], 'Q.': [3473], 'Double': [3474], 'Sayyed': [3476], '44:': [3483], '3-21Crossref': [3484], '(229)': [3487], 'Not': [3490], 'medicines,': [3493], 'but': [3494], 'accumulate': [3499], 'circuit': [3503], 'benefit': [3505], 'Sc': [4198]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2097707410', 'counts_by_year': [{'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 2}, {'year': 2013, 'cited_by_count': 3}, {'year': 2012, 'cited_by_count': 4}], 'updated_date': '2024-12-12T07:20:32.821330', 'created_date': '2016-06-24'}