Publication Information

{'id': 'https://openalex.org/W2097643979', 'doi': 'https://doi.org/10.1146/annurev.pharmtox.44.101802.121429', 'title': 'Analysis of GABA<sub>A</sub> Receptor Function and Dissection of the Pharmacology of Benzodiazepines and General Anesthetics Through Mouse Genetics', 'display_name': 'Analysis of GABA<sub>A</sub> Receptor Function and Dissection of the Pharmacology of Benzodiazepines and General Anesthetics Through Mouse Genetics', 'publication_year': 2004, 'publication_date': '2004-01-27', 'ids': {'openalex': 'https://openalex.org/W2097643979', 'doi': 'https://doi.org/10.1146/annurev.pharmtox.44.101802.121429', 'mag': '2097643979', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/14744255'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1146/annurev.pharmtox.44.101802.121429', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S163849586', 'display_name': 'The Annual Review of Pharmacology and Toxicology', 'issn_l': '0362-1642', 'issn': ['0362-1642', '1545-4304'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320373', 'host_organization_name': 'Annual Reviews', 'host_organization_lineage': ['https://openalex.org/P4310320373'], 'host_organization_lineage_names': ['Annual Reviews'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5036255755', 'display_name': 'Uwe Rudolph', 'orcid': 'https://orcid.org/0000-0001-9396-4746'}, 'institutions': [{'id': 'https://openalex.org/I202697423', 'display_name': 'University of Zurich', 'ror': 'https://ror.org/02crff812', 'country_code': 'CH', 'type': 'education', 'lineage': ['https://openalex.org/I202697423']}, {'id': 'https://openalex.org/I4210165424', 'display_name': 'Institute of Pharmacology', 'ror': 'https://ror.org/01ss14a40', 'country_code': 'CZ', 'type': 'facility', 'lineage': ['https://openalex.org/I21250087', 'https://openalex.org/I4210165424']}], 'countries': ['CH', 'CZ'], 'is_corresponding': False, 'raw_author_name': 'Uwe Rudolph', 'raw_affiliation_strings': ['Institute of Pharmacology and Toxicology, University of Zurich, Winterthurerstrasse 190, CH-8057 Zürich;,'], 'affiliations': [{'raw_affiliation_string': 'Institute of Pharmacology and Toxicology, University of Zurich, Winterthurerstrasse 190, CH-8057 Zürich;,', 'institution_ids': ['https://openalex.org/I202697423', 'https://openalex.org/I4210165424']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5106235440', 'display_name': 'Hanns Möhler', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I202697423', 'display_name': 'University of Zurich', 'ror': 'https://ror.org/02crff812', 'country_code': 'CH', 'type': 'education', 'lineage': ['https://openalex.org/I202697423']}, {'id': 'https://openalex.org/I4210165424', 'display_name': 'Institute of Pharmacology', 'ror': 'https://ror.org/01ss14a40', 'country_code': 'CZ', 'type': 'facility', 'lineage': ['https://openalex.org/I21250087', 'https://openalex.org/I4210165424']}], 'countries': ['CH', 'CZ'], 'is_corresponding': False, 'raw_author_name': 'Hanns Möhler', 'raw_affiliation_strings': ['Institute of Pharmacology and Toxicology, University of Zurich, Winterthurerstrasse 190, CH-8057 Zürich;,'], 'affiliations': [{'raw_affiliation_string': 'Institute of Pharmacology and Toxicology, University of Zurich, Winterthurerstrasse 190, CH-8057 Zürich;,', 'institution_ids': ['https://openalex.org/I202697423', 'https://openalex.org/I4210165424']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 6.067, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 524, 'citation_normalized_percentile': {'value': 0.998056, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '44', 'issue': '1', 'first_page': '475', 'last_page': '498'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10077', 'display_name': 'Neuroscience and Neuropharmacology Research', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10077', 'display_name': 'Neuroscience and Neuropharmacology Research', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10448', 'display_name': 'Memory and Neural Mechanisms', 'score': 0.9992, 'subfield': {'id': 'https://openalex.org/subfields/2805', 'display_name': 'Cognitive Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11708', 'display_name': 'Photochromic and Fluorescence Chemistry', 'score': 0.9928, 'subfield': {'id': 'https://openalex.org/subfields/2505', 'display_name': 'Materials Chemistry'}, 'field': {'id': 'https://openalex.org/fields/25', 'display_name': 'Materials Science'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/knockout-mouse', 'display_name': 'Knockout mouse', 'score': 0.5429132}], 'concepts': [{'id': 'https://openalex.org/C168258287', 'wikidata': 'https://www.wikidata.org/wiki/Q60147', 'display_name': 'GABAA receptor', 'level': 3, 'score': 0.81345123}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.6315697}, {'id': 'https://openalex.org/C2778173252', 'wikidata': 'https://www.wikidata.org/wiki/Q83871', 'display_name': 'Benzodiazepine', 'level': 3, 'score': 0.5768251}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.57099795}, {'id': 'https://openalex.org/C182704531', 'wikidata': 'https://www.wikidata.org/wiki/Q1364740', 'display_name': 'Knockout mouse', 'level': 3, 'score': 0.5429132}, {'id': 'https://openalex.org/C2776175493', 'wikidata': 'https://www.wikidata.org/wiki/Q210402', 'display_name': 'Diazepam', 'level': 2, 'score': 0.4995656}, {'id': 'https://openalex.org/C169760540', 'wikidata': 'https://www.wikidata.org/wiki/Q207011', 'display_name': 'Neuroscience', 'level': 1, 'score': 0.44943723}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.42121166}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.3039269}], 'mesh': [{'descriptor_ui': 'D018681', 'descriptor_name': 'Anesthetics, General', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D001569', 'descriptor_name': 'Benzodiazepines', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D011963', 'descriptor_name': 'Receptors, GABA-A', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D011963', 'descriptor_name': 'Receptors, GABA-A', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D018681', 'descriptor_name': 'Anesthetics, General', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001569', 'descriptor_name': 'Benzodiazepines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018345', 'descriptor_name': 'Mice, Knockout', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D021122', 'descriptor_name': 'Protein Subunits', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D021122', 'descriptor_name': 'Protein Subunits', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D021122', 'descriptor_name': 'Protein Subunits', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D011963', 'descriptor_name': 'Receptors, GABA-A', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1146/annurev.pharmtox.44.101802.121429', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S163849586', 'display_name': 'The Annual Review of Pharmacology and Toxicology', 'issn_l': '0362-1642', 'issn': ['0362-1642', '1545-4304'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320373', 'host_organization_name': 'Annual Reviews', 'host_organization_lineage': ['https://openalex.org/P4310320373'], 'host_organization_lineage_names': ['Annual Reviews'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/14744255', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being', 'score': 0.82}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 103, 'referenced_works': ['https://openalex.org/W1498924248', 'https://openalex.org/W1541419413', 'https://openalex.org/W1550227666', 'https://openalex.org/W1563564990', 'https://openalex.org/W1565475713', 'https://openalex.org/W1565551672', 'https://openalex.org/W1581467941', 'https://openalex.org/W1602497443', 'https://openalex.org/W1664830349', 'https://openalex.org/W1668093331', 'https://openalex.org/W1824285989', 'https://openalex.org/W1834606595', 'https://openalex.org/W1868109033', 'https://openalex.org/W1879000632', 'https://openalex.org/W1964277437', 'https://openalex.org/W1966231083', 'https://openalex.org/W1967100736', 'https://openalex.org/W1967380120', 'https://openalex.org/W1967737931', 'https://openalex.org/W1970006557', 'https://openalex.org/W1970263679', 'https://openalex.org/W1970915837', 'https://openalex.org/W1978330774', 'https://openalex.org/W1983109615', 'https://openalex.org/W1985881933', 'https://openalex.org/W1993462849', 'https://openalex.org/W1999032965', 'https://openalex.org/W1999475698', 'https://openalex.org/W2001619275', 'https://openalex.org/W2004974848', 'https://openalex.org/W2007031766', 'https://openalex.org/W2017773935', 'https://openalex.org/W2021213638', 'https://openalex.org/W2024422476', 'https://openalex.org/W2027526028', 'https://openalex.org/W2028058817', 'https://openalex.org/W2030492864', 'https://openalex.org/W2030928110', 'https://openalex.org/W2036756639', 'https://openalex.org/W2039738625', 'https://openalex.org/W2041359982', 'https://openalex.org/W2046047992', 'https://openalex.org/W2050078067', 'https://openalex.org/W2050243692', 'https://openalex.org/W2055141776', 'https://openalex.org/W2058929671', 'https://openalex.org/W2059080764', 'https://openalex.org/W2060589548', 'https://openalex.org/W2067393309', 'https://openalex.org/W2071913275', 'https://openalex.org/W2072614922', 'https://openalex.org/W2073015466', 'https://openalex.org/W2080639248', 'https://openalex.org/W2081165682', 'https://openalex.org/W2081357350', 'https://openalex.org/W2081985979', 'https://openalex.org/W2082076549', 'https://openalex.org/W2083547018', 'https://openalex.org/W2083623577', 'https://openalex.org/W2084672354', 'https://openalex.org/W2088909919', 'https://openalex.org/W2089014083', 'https://openalex.org/W2089571336', 'https://openalex.org/W2090740029', 'https://openalex.org/W2095265457', 'https://openalex.org/W2097750478', 'https://openalex.org/W2097917275', 'https://openalex.org/W2099512174', 'https://openalex.org/W2100231995', 'https://openalex.org/W2101437635', 'https://openalex.org/W2101986800', 'https://openalex.org/W2108776106', 'https://openalex.org/W2112332687', 'https://openalex.org/W2112444339', 'https://openalex.org/W2115904392', 'https://openalex.org/W2119565218', 'https://openalex.org/W2121237571', 'https://openalex.org/W2124025293', 'https://openalex.org/W2124764306', 'https://openalex.org/W2125277337', 'https://openalex.org/W2133458388', 'https://openalex.org/W2134766199', 'https://openalex.org/W2137084591', 'https://openalex.org/W2137303544', 'https://openalex.org/W2138001567', 'https://openalex.org/W2138750316', 'https://openalex.org/W2141896877', 'https://openalex.org/W2141953895', 'https://openalex.org/W2143086898', 'https://openalex.org/W2148691225', 'https://openalex.org/W2148975169', 'https://openalex.org/W2162515150', 'https://openalex.org/W2162666247', 'https://openalex.org/W2165062318', 'https://openalex.org/W2165223719', 'https://openalex.org/W2165654705', 'https://openalex.org/W2166873937', 'https://openalex.org/W2171381392', 'https://openalex.org/W2171792283', 'https://openalex.org/W2181518245', 'https://openalex.org/W2337967379', 'https://openalex.org/W4317524245', 'https://openalex.org/W80223889'], 'related_works': ['https://openalex.org/W567427839', 'https://openalex.org/W2086746233', 'https://openalex.org/W2072174668', 'https://openalex.org/W2054507565', 'https://openalex.org/W2049253858', 'https://openalex.org/W2046005407', 'https://openalex.org/W2031212745', 'https://openalex.org/W2016393227', 'https://openalex.org/W2003863749', 'https://openalex.org/W1996020865'], 'abstract_inverted_index': {'GABA': [0, 23, 44, 58, 125], 'A': [1, 24, 45, 59, 126], 'receptors': [2], 'are': [3, 129], 'molecular': [4], 'substrates': [5], 'for': [6, 32], 'the': [7, 20, 30, 33, 80, 92, 102, 118, 139, 147], 'regulation': [8, 103], 'of': [9, 22, 35, 43, 82, 104, 114, 142, 150], 'vigilance,': [10], 'anxiety,': [11], 'muscle': [12], 'tension,': [13], 'epileptogenic': [14], 'activity,': [15], 'and': [16, 19, 38, 69, 71, 89, 110, 152], 'memory': [17], 'functions,': [18], 'enhancement': [21], 'receptor-mediated': [25], 'fast': [26], 'synaptic': [27], 'inhibition': [28], 'is': [29], 'basis': [31], 'pharmacotherapy': [34], 'various': [36], 'neurological': [37], 'psychiatric': [39], 'disorders.': [40], 'Two': [41], 'kinds': [42], 'receptor-targeted': [46], 'mutant': [47], 'mice': [48, 54, 74, 94, 121], 'have': [49, 95, 137], 'been': [50], 'generated:': [51], '(a)': [52], 'knockout': [53, 93], 'that': [55, 75], 'lack': [56], 'individual': [57, 115, 143], 'receptor': [60, 108, 116, 127, 144], 'subunits': [61], '(α1,': [62], 'α5,': [63], 'α6,': [64], 'β2,': [65], 'β3,': [66], 'γ2,': [67], 'δ,': [68], 'ρ1)': [70], '(b)': [72], 'knockin': [73, 120], 'carry': [76], 'point': [77], 'mutations': [78], 'affecting': [79], 'action': [81], 'modulatory': [83], 'drugs': [84], '[α1(H101R),': [85], 'α2(H101R),': [86], 'α3(H126R),': [87], 'α5(H105R),': [88], 'β3(N265M)].': [90], 'Whereas': [91], 'provided': [96], 'information': [97], 'primarily': [98], 'with': [99], 'respect': [100], 'to': [101, 131, 146], 'subunit': [105], 'gene': [106], 'transcription,': [107], 'assembly,': [109], 'some': [111, 134], 'physiological': [112], 'functions': [113], 'subtypes,': [117], 'point-mutated': [119], 'in': [122], 'which': [123], 'specific': [124, 140], 'subtypes': [128, 145], 'insensitive': [130], 'diazepam': [132, 151], 'or': [133], 'general': [135, 153], 'anesthetics': [136], 'revealed': [138], 'contribution': [141], 'pharmacological': [148], 'spectrum': [149], 'anesthetics.': [154]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2097643979', 'counts_by_year': [{'year': 2024, 'cited_by_count': 13}, {'year': 2023, 'cited_by_count': 11}, {'year': 2022, 'cited_by_count': 14}, {'year': 2021, 'cited_by_count': 13}, {'year': 2020, 'cited_by_count': 14}, {'year': 2019, 'cited_by_count': 13}, {'year': 2018, 'cited_by_count': 16}, {'year': 2017, 'cited_by_count': 14}, {'year': 2016, 'cited_by_count': 18}, {'year': 2015, 'cited_by_count': 24}, {'year': 2014, 'cited_by_count': 30}, {'year': 2013, 'cited_by_count': 24}, {'year': 2012, 'cited_by_count': 33}], 'updated_date': '2024-12-14T01:51:13.700904', 'created_date': '2016-06-24'}