Publication Information

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257, 298, 316, 327, 338, 524, 605, 615, 791, 1064, 1114, 1149, 1260, 1297, 1370, 1387, 1434, 1457, 1471, 1567, 1659, 2387, 2634, 3152, 3479, 3775, 3784, 3972], 'divides': [12, 232], 'glioblastoma': [13, 233, 764, 956, 988, 2100, 2802, 2979, 3085, 4078], '(GBM)': [14, 234, 453], 'into': [15, 235], 'four': [16, 236, 803], 'transcriptional': [17, 25, 92, 99, 237, 245, 312, 319, 805, 828, 849, 867, 1111, 1139, 1176, 1227, 1252, 1279, 1335, 1391, 2153, 2560, 2571, 2697, 2806, 2983, 3741, 4058, 4133, 4240], 'classes:': [18, 238], 'proneural,': [19, 239, 844], 'neural,': [20, 240, 845], 'classical,': [21, 241, 846], 'and': [22, 53, 61, 146, 183, 196, 212, 242, 273, 281, 366, 403, 416, 432, 463, 495, 533, 578, 600, 668, 687, 772, 809, 815, 821, 847, 853, 964, 990, 1097, 1101, 1104, 1141, 1163, 1169, 1185, 1194, 1281, 1324, 1341, 1346, 1353, 1386, 1402, 1436, 1464, 1487, 1491, 1527, 1574, 1615, 1698, 1720, 1736, 1847, 1930, 1956, 1997, 2108, 2146, 2206, 2246, 2256, 2306, 2434, 2473, 2503, 2521, 2533, 2573, 2592, 2651, 2699, 2734, 2747, 2761, 2795, 2831, 2837, 2854, 2881, 2907, 2972, 3008, 3014, 3161, 3188, 3202, 3230, 3245, 3249, 3263, 3279, 3293, 3316, 3347, 3350, 3363, 3379, 3421, 3424, 3437, 3484, 3509, 3538, 3573, 3576, 3584, 3633, 3687, 3743, 3924, 3933, 4016, 4027, 4029, 4080, 4155, 4214, 4222, 4235], 'mesenchymal.': [23, 243], 'Because': [24, 244, 3912, 4091], 'class': [26, 100, 135, 165, 246, 320, 355, 385, 829, 1373, 1421, 2001, 2154, 2561, 2572, 3742, 3752, 3778, 3813, 3889, 3923, 3991], 'is': [27, 58, 247, 278, 459, 2430, 2499], 'only': [28, 248, 525, 1118, 1693, 3682], 'partially': [29, 249, 1119], 'explained': [30, 250], 'by': [31, 198, 251, 418, 766, 958, 1365, 1441, 1558, 1589, 1662, 1731, 1969, 2023, 2102, 2310, 2465, 2540, 2640, 2644, 2689, 2840, 2860, 3017, 3210, 3318, 3655, 3877], 'underlying': [32, 252, 622], 'genomic': [33, 253, 601, 757, 949, 984, 1091, 2093, 3422, 4069, 4074], 'alterations,': [34, 254, 811], 'we': [35, 49, 94, 255, 269, 314, 1319, 1432, 1652, 3425, 3558, 3646, 3749, 3773, 3935, 3970, 4048, 4103], 'hypothesize': [36, 256], 'the': [38, 97, 121, 132, 151, 163, 177, 258, 317, 341, 352, 371, 383, 397, 460, 479, 501, 511, 613, 854, 865, 880, 1088, 1121, 1151, 1154, 1179, 1188, 1195, 1263, 1293, 1354, 1366, 1371, 1388, 1394, 1408, 1419, 1448, 1458, 1513, 1537, 1544, 1568, 1571, 1583, 1595, 1676, 1712, 1741, 1814, 1831, 1870, 1921, 1924, 1957, 1971, 1980, 2009, 2017, 2138, 2167, 2172, 2191, 2222, 2264, 2269, 2286, 2313, 2574, 2608, 2660, 2679, 2685, 2690, 2917, 2924, 2930, 3181, 3340, 3355, 3361, 3429, 3534, 3630, 3717, 3754, 3760, 3776, 3799, 3825, 3867, 3887, 3920, 3929, 3938, 3989, 4130, 4149, 4219], 'tumor': [39, 259, 819, 1264, 1267, 3802], 'microenvironment': [40, 260], 'may': [41, 213, 261, 433, 1476, 3915], 'also': [42, 262, 3814, 3891], 'have': [43, 263, 603, 788, 2946], 'an': [44, 264, 1321, 1533, 2240], 'impact.': [45, 265], 'In': [46, 171, 266, 391, 1918, 3759, 3884, 3961], 'this': [47, 267, 606, 1602, 3885, 4105], 'study,': [48, 268], 'focused': [50, 270, 3427], 'on': [51, 271, 443, 449, 1532, 1618, 1631, 1647, 1740, 2768, 3175, 3226, 3428, 3726], 'necrosis': [52, 124, 211, 272, 344, 431, 1347, 1617, 1648, 1678, 1719, 1824, 1955, 1974, 2145, 2255, 2472, 2701, 3436, 3472, 3537, 3583, 3594, 3632, 3667, 3695, 3728, 3746, 3768, 3790, 3820, 3876, 3898, 3932, 3941, 3974, 4097, 4234], 'angiogenesis': [54, 274, 1345, 1721, 1826, 1960, 1976, 2147, 2257, 3513, 3539, 3585, 3610, 3634, 3844, 4026], 'because': [55, 275], 'their': [56, 207, 217, 276, 427, 437], 'presence': [57, 277, 2575], 'both': [59, 279, 1278], 'prognostically': [60, 280], 'biologically': [62, 282], 'significant.': [63, 283], 'These': [64, 284, 2723, 4111], 'features': [65, 90, 285, 310, 1742, 3415], 'were': [66, 79, 136, 155, 185, 286, 299, 356, 375, 405, 1171, 1254, 1404, 1438, 1510, 1525, 1555, 1577, 1660, 1706, 1722, 1803, 1817, 1827, 1838, 1934, 1942, 1961, 1986, 2006, 2148, 2164, 2252, 2258, 2308, 2524, 2528, 2594, 2638, 2702, 2714, 2753, 2766, 2852, 2866, 2914, 2934, 3032, 3148, 3173, 3208, 3224, 3236, 3291, 3352, 3390, 3529, 3653, 3858, 3872, 4023], 'quantified': [67, 287], 'in': [68, 125, 150, 202, 288, 345, 370, 422, 500, 504, 671, 768, 800, 864, 960, 1093, 1109, 1348, 1496, 1649, 1702, 1783, 2104, 2432, 2501, 2755, 2801, 2978, 3030, 3037, 3042, 3046, 3084, 3143, 3150, 3238, 3416, 3473, 3514, 3540, 3691, 3696, 3894, 3919, 4033, 4129, 4159, 4227, 4249], 'digitized': [69, 289, 1355, 1504, 1528, 1607, 3560], 'histological': [70, 290], 'images': [71, 291, 1356, 1505, 1608, 3561, 3579], 'of': [72, 112, 123, 169, 176, 194, 292, 332, 343, 389, 396, 414, 476, 478, 510, 595, 657, 665, 763, 794, 817, 831, 955, 1058, 1069, 1087, 1129, 1146, 1181, 1190, 1232, 1249, 1262, 1327, 1344, 1374, 1384, 1390, 1393, 1410, 1425, 1450, 1461, 1485, 1506, 1613, 1645, 1656, 1685, 1715, 1718, 1800, 1850, 1867, 1869, 1903, 1907, 1954, 1959, 1966, 1973, 2020, 2099, 2158, 2244, 2250, 2272, 2282, 2303, 2381, 2392, 2468, 2471, 2548, 2576, 2616, 2631, 2649, 2663, 2667, 2674, 2692, 2721, 2738, 2743, 3048, 3081, 3180, 3200, 3220, 3366, 3413, 3434, 3447, 3451, 3512, 3527, 3533, 3536, 3544, 3582, 3603, 3609, 3619, 3649, 3674, 3707, 3720, 3745, 3756, 3762, 3789, 3792, 3835, 3843, 3869, 3905, 3931, 3940, 3963, 3996, 4001, 4068, 4122, 4144, 4212], 'TCGA': [73, 152, 293, 372, 1514, 1538, 1590, 1663, 2004, 2010, 2132, 2192, 2545, 3545, 3656, 3878], 'GBM': [74, 105, 203, 294, 325, 423, 795, 1130, 1334, 1349, 1375, 1429, 1507, 1650, 2168, 2553, 2712, 2751, 2939, 3417, 3850, 4034], 'frozen': [75, 295, 1359, 1508, 1552, 1667, 3541, 3566, 3660], 'section': [76, 296, 1523, 1553, 1573, 1576, 1668, 1983, 3542, 3567, 3661], 'slides': [77, 297, 1524, 1554, 1600, 1620, 1633, 1669, 1990, 3543, 3662], 'immediately': [80, 300, 1592], 'adjacent': [81, 301, 1593, 1811, 2748], 'to': [82, 130, 157, 162, 216, 302, 350, 377, 382, 436, 1137, 1153, 1173, 1287, 1303, 1312, 1333, 1418, 1565, 1594, 1598, 1625, 1638, 1743, 1805, 1920, 1979, 1994, 2128, 2196, 2233, 2285, 2461, 2530, 2610, 2618, 2678, 2856, 3034, 3155, 3167, 3232, 3299, 3359, 3374, 3381, 3570, 3598, 3614, 3702, 3798, 3900, 3928, 3944, 4054, 4060, 4107, 4127, 4164], 'samples': [83, 106, 303, 326, 1379, 1623, 1636, 1708, 2021, 2133, 2208, 2229, 2554, 2637, 3546, 3572, 3713, 3783, 3895, 3965, 4053, 4128, 4229, 4236], 'used': [84, 304, 1133, 1311, 1361, 1585, 1597, 1605, 1653, 3029, 3197, 3335, 3530, 3647], 'for': [85, 206, 305, 426, 486, 581, 824, 1187, 1229, 1362, 1447, 1479, 1562, 1579, 1586, 1601, 1670, 1782, 1877, 2003, 2144, 2150, 2551, 2589, 2862, 3198, 3257, 3310, 3339, 3376, 3384, 3548, 3580, 3663, 3753, 3767, 3875], 'molecular': [86, 306, 610, 1308, 1325, 1351, 1580, 1587, 2428, 2497, 3552, 3771], 'analysis.': [87, 307, 1704, 3553, 3693], 'Correlating': [88, 308], 'these': [89, 309, 1250, 1317, 1451, 1472, 1606, 1674, 2664, 3697, 3757, 3864], 'with': [91, 104, 120, 166, 187, 210, 311, 324, 340, 386, 407, 430, 873, 1378, 1407, 1422, 1453, 1709, 2152, 2155, 2230, 2239, 2260, 2555, 2599, 2730, 2741, 2869, 2936, 3130, 3254, 3295, 3418, 3600, 3616, 3704, 3714, 3769, 3782, 3794, 3806, 3849, 3896, 3966, 3978, 3988, 4004, 4095, 4148, 4230], 'data,': [93, 313, 3721, 3772, 3969], 'found': [95, 156, 315, 376, 1172, 1369, 3774, 3971], 'mesenchymal': [98, 133, 164, 179, 318, 353, 384, 399, 848, 881, 1155, 1196, 1230, 1372, 1395, 1420, 2603, 2636, 2650, 2655, 2669, 2680, 3777, 3812, 3859, 3888, 4052, 4114, 4152], 'was': [101, 321, 1376, 1591, 1629, 1679, 1691, 1699, 2194, 2201, 2226, 2320, 2459, 2538, 2582, 2605, 2657, 2682, 3196, 3334, 3370, 3403, 3624, 3668, 3680, 3688, 3723, 3737, 3779, 3845, 3890, 3942, 3975, 4139], 'significantly': [102, 322, 3780, 3847, 3892, 3976], 'enriched': [103, 323, 1377, 2431, 2500, 3781, 3893], 'contained': [108, 328, 2736], 'a': [109, 188, 329, 408, 521, 663, 1059, 1066, 1134, 1143, 1381, 1467, 1642, 1682, 1738, 1888, 1964, 2247, 2382, 2389, 3122, 3211, 3227, 3475, 3555, 3587, 3601, 3617, 3625, 3643, 3671, 3705, 3738, 3786, 3816, 3917, 3993, 3997, 4010, 4065, 4119, 4141, 4250], 'high': [110, 173, 330, 393, 1382, 1459, 3787, 3897], 'degree': [111, 122, 331, 342, 1383, 3535, 3581, 3608, 3788], 'necrosis.': [113, 170, 333, 390, 1411, 1426, 1454], 'Furthermore,': [114, 334], 'among': [115, 335, 835, 2438, 2507, 4013], '2422': [116, 336], 'genes': [117, 337, 989, 4079], 'correlated': [119, 339, 1406, 2259], 'GBMs,': [126, 346, 3651, 3870], 'transcription': [127, 347, 1147], 'factors': [128, 180, 348, 400, 1148, 1329, 1452], 'known': [129, 349], 'drive': [131, 351], 'most': [137, 357, 461], 'closely': [138, 358], 'related,': [139, 359, 1300], 'including': [140, 360, 812, 1095, 1157, 1266, 1927], 'C/EBP-β,': [141, 181, 361, 401, 1158, 1167, 1397, 1462, 2304, 2590, 3345], 'C/EBP-δ,': [142, 182, 362, 402, 1159, 1168, 1398, 1463, 2305, 2591, 3346], 'STAT3,': [143, 363, 1160, 1399], 'FOSL2,': [144, 364, 1161, 1400], 'bHLHE40,': [145, 365, 1162, 1401], 'RUNX1.': [147, 367, 1164], 'Non-mesenchymal': [148, 368], 'GBMs': [149, 369, 1413, 1658, 2724, 3764, 4055, 4094, 4115, 4162], 'set': [154, 374, 1145, 2019, 2630, 3761, 3868, 4000, 4121, 4143], 'become': [158, 378], 'more': [159, 379, 1415, 3998, 4231], 'transcriptionally': [160, 380, 1416], 'similar': [161, 381, 1417], 'increasing': [167, 387, 1423], 'levels': [168, 175, 388, 395, 1424], 'addition,': [172, 392], 'master': [178, 398, 1175, 1251], 'STAT3': [184, 404, 1170, 1465, 2307, 2593, 3348], 'associated': [186, 406, 3770, 3848, 3977, 4147], 'poor': [189, 218, 409, 438, 1468], 'prognosis.': [190, 219, 410, 439], 'Strong,': [191, 411], 'specific': [192, 412, 3256], 'C/EBP-β': [195, 415, 1435, 2889, 3269], 'C/EBP-δ': [197, 417, 2893, 3274], 'hypoxic,': [199, 419, 1442], 'perinecrotic': [200, 420], 'cells': [201, 421], 'likely': [204, 424], 'account': [205, 425, 823], 'tight': [208, 428], 'association': [209, 429, 1449, 2151, 4012], 'be': [214, 434, 619, 1174, 1304, 3926], 'related': [215, 435, 441, 447, 1488, 3927, 3943], 'See': [440, 446], 'Commentary': [442, 448], 'page': [444, 450], '1768': [445, 451], 'Glioblastoma': [452], '(World': [454], 'Health': [455], 'Organization,': [456], 'grade': [457, 465], 'IV)': [458], 'common': [462], 'highest': [464], 'astrocytoma.1Louis': [466], 'D.N.': [467, 755, 947, 1026, 1858, 2091, 2349], 'Ohgaki': [468, 1859], 'H.': [469, 644, 1002, 1040, 1042, 1217, 1860, 2325, 2363, 2365], 'Wiestler': [470, 1861], 'O.D.': [471, 1862], 'Cavenee': [472, 1863], 'W.K.': [473, 1201, 1864], 'WHO': [474, 1865], 'classification': [475, 1866, 2609], 'tumours': [477, 1868], 'central': [480, 496, 1871], 'nervous': [481, 497, 1872], 'system.4th': [482, 1873], 'ed.': [483, 1874], 'Intl.': [484, 1875], 'Agency': [485, 1876], 'Research,': [487, 1878], 'Lyon2007Google': [488, 1879], 'Scholar,': [489, 979, 1000, 1880, 1893, 2407, 2816, 2993, 3099, 3461, 3496], '2CBTRUSCBTRUS': [490], 'statistical': [491, 4099], 'report:': [492], 'primary': [493, 1611, 3556], 'brain': [494, 1233], 'system': [498], 'tumors': [499, 872], 'United': [502, 512], 'States': [503], '2004–2006.': [505], 'Central': [506], 'Brain': [507], 'Tumor': [508], 'Registry': [509], 'States,': [513], 'Hinsdale,': [514], 'IL2010Google': [515], 'Scholar': [516, 593, 686, 787, 1084, 1242, 1797, 1917, 2123, 2300, 2449, 2518, 2628, 2850, 3027, 3524, 4090], 'Currently': [517], 'incurable,': [518], 'it': [519], 'mean': [522, 3399, 3602, 3618, 3706, 3818], 'survival': [523, 2437, 2506, 3351], 'slightly': [526], 'exceeds': [527], '1': [528, 3311], 'year': [529], 'following': [530], 'standard': [531], 'surgical': [532, 1886], 'adjuvant': [534, 579], 'therapies.3Stupp': [535], 'R.': [536, 632, 2277, 3060], 'Mason': [537], 'W.P.': [538], 'van': [539], 'den': [540], 'Bent': [541], 'M.J.': [542, 548, 1203], 'Weller': [543], 'M.': [544, 713, 715, 749, 905, 907, 941, 2049, 2051, 2085, 3113], 'Fisher': [545], 'B.': [546, 3498], 'Taphoorn': [547], 'Belanger': [549], 'K.': [550, 654, 1006, 1010, 1056, 1221, 2329, 2333, 2379], 'Brandes': [551], 'A.A.': [552], 'Marosi': [553], 'C.': [554, 737, 929, 2073, 2777, 2954, 3500], 'Bogdahn': [555], 'U.': [556], 'Curschmann': [557], 'J.': [558, 1048, 1749, 2371], 'Janzer': [559], 'R.C.': [560], 'Ludwin': [561], 'S.K.': [562], 'Gorlia': [563], 'T.': [564, 707, 899, 1763, 2043, 2419, 2488], 'Allgeier': [565], 'A.': [566, 640, 739, 931, 1219, 1223, 1225, 1761, 1882, 2075], 'Lacombe': [567], 'D.': [568, 1038, 2361], 'Cairncross': [569], 'J.G.': [570, 731, 923, 1050, 2067, 2373], 'Eisenhauer': [571], 'E.': [572, 695, 887, 2031], 'Mirimanoff': [573], 'R.O.': [574, 2822, 2999], 'Radiotherapy': [575], 'plus': [576], 'concomitant': [577], 'temozolomide': [580], 'glioblastoma.N': [582], 'Engl': [583], 'J': [584], 'Med.': [585], '2005;': [586, 2621, 2843, 3020], '352:': [587], '987-996Crossref': [588], 'PubMed': [589, 682, 783, 975, 996, 1080, 1238, 1793, 1913, 2119, 2403, 2445, 2514, 2624, 2812, 2846, 2989, 3023, 3095, 3136, 3457, 3492, 3520, 4086], 'Scopus': [590, 683, 784, 976, 997, 1081, 1239, 1794, 1914, 2120, 2297, 2404, 2446, 2515, 2625, 2813, 2847, 2990, 3024, 3096, 3137, 3458, 3493, 3521, 4087], '(12735)': [591], 'Google': [592, 685, 786, 978, 999, 1083, 1241, 1796, 1916, 2122, 2299, 2406, 2448, 2517, 2627, 2815, 2849, 2992, 3026, 3098, 3139, 3460, 3495, 3523, 4089], 'Analyses': [594], 'large': [596], 'scale': [597], 'datasets': [602], 'indicated': [604, 3182], 'disease': [607, 666], 'represents': [608], 'multiple': [609, 1110, 1989, 2231], 'subclasses,': [611], 'raising': [612], 'possibility': [614], 'future': [616], 'therapies': [617], 'could': [618, 1275, 3925], 'directed': [620, 2871], 'at': [621, 825, 1501, 1529, 1536, 1543, 2171, 3164, 3252, 3313], 'class-specific': [623, 1122], 'mechanisms.': [624], 'Phillips': [625, 1007, 2330], 'et': [626, 689, 2025], 'al4Phillips': [627], 'H.S.': [628, 729, 921, 1008, 2065, 2331], 'Kharbanda': [629], 'S.': [630, 721, 725, 913, 917, 2057, 2061], 'Chen': [631, 2778, 2955], 'Forrest': [633], 'W.F.': [634], 'Soriano': [635], 'R.H.': [636], 'Wu': [637], 'T.D.': [638], 'Misra': [639], 'Nigro': [641], 'J.M.': [642, 3064], 'Colman': [643, 1216], 'Soroceanu': [645], 'L.': [646, 705, 727, 897, 919, 1032, 2041, 2063, 2355], 'Williams': [647], 'P.M.': [648, 1759], 'Modrusan': [649], 'Z.': [650, 3111], 'Feuerstein': [651], 'B.G.': [652], 'Aldape': [653, 1055, 1220, 2378], 'Molecular': [655], 'subclasses': [656], 'high-grade': [658, 2739], 'glioma': [659, 1785, 2740], 'predict': [660], 'prognosis,': [661], 'delineate': [662], 'pattern': [664], 'progression,': [667], 'resemble': [669], 'stages': [670], 'neurogenesis.Cancer': [672], 'Cell.': [673, 774, 966, 1071, 2110, 2394], '2006;': [674, 3092, 3489], '9:': [675], '157-173Abstract': [676], 'Full': [677, 679, 778, 780, 970, 972, 1075, 1077, 2114, 2116, 2398, 2400], 'Text': [678, 680, 779, 781, 971, 973, 1076, 1078, 2115, 2117, 2399, 2401], 'PDF': [681, 782, 974, 1079, 2118, 2402], '(2114)': [684], 'Verhaak': [688, 1021, 2024, 2344], 'al5Verhaak': [690, 2026], 'R.G.': [691, 883, 1022, 2027, 2345], 'Hoadley': [692, 884, 1023, 2028, 2346], 'K.A.': [693, 885, 1024, 2029, 2347], 'Purdom': [694, 886, 2030], 'Wang': [696, 888, 1752, 2032], 'V.': [697, 889, 2033], 'Qi': [698, 890, 2034], 'Y.': [699, 891, 2035, 2773, 2818, 2950, 2995, 3056, 3463], 'Wilkerson': [700, 892, 2036], 'M.D.': [701, 893, 2037], 'Miller': [702, 894, 2038], 'C.R.': [703, 895, 2039], 'Ding': [704, 896, 1031, 2040, 2354], 'Golub': [706, 898, 2042], 'Mesirov': [708, 900, 2044], 'J.P.': [709, 901, 2045], 'Alexe': [710, 902, 2046], 'G.': [711, 751, 903, 943, 2047, 2087, 2279, 2779, 2956], 'Lawrence': [712, 904, 2048], "O'Kelly": [714, 906, 2050], 'Tamayo': [716, 908, 2052], 'P.': [717, 909, 1044, 2053, 2367], 'Weir': [718, 910, 2054], 'B.A.': [719, 911, 2055, 2415, 2484], 'Gabriel': [720, 912, 2056], 'Winckler': [722, 914, 2058], 'W.': [723, 915, 2059], 'Gupta': [724, 916, 2060], 'Jakkula': [726, 918, 2062], 'Feiler': [728, 920, 2064], 'Hodgson': [730, 922, 2066], 'James': [732, 924, 2068], 'C.D.': [733, 925, 2069], 'Sarkaria': [734, 926, 2070], 'J.N.': [735, 927, 2071], 'Brennan': [736, 928, 2072], 'Kahn': [738, 930, 2074], 'Spellman': [740, 932, 2076], 'P.T.': [741, 933, 2077], 'Wilson': [742, 934, 1033, 2078, 2356], 'R.K.': [743, 935, 1034, 2079, 2357], 'Speed': [744, 936, 2080], 'T.P.': [745, 937, 2081], 'Gray': [746, 938, 2082], 'J.W.': [747, 939, 2083], 'Meyerson': [748, 940, 2084], 'Getz': [750, 942, 2086], 'Perou': [752, 944, 1027, 2088, 2350], 'C.M.': [753, 945, 1028, 2089, 2351], 'Hayes': [754, 946, 1025, 2090, 2348], 'Integrated': [756, 948, 2092], 'analysis': [758, 950, 1128, 1326, 1588, 2094, 2157, 2170, 2271, 2281, 2467, 2470, 3389, 3834, 3904, 3962], 'identifies': [759, 951, 2095], 'clinically': [760, 952, 2096], 'relevant': [761, 953, 2097], 'subtypes': [762, 954, 2098, 3803], 'characterized': [765, 957, 1090, 2101], 'abnormalities': [767, 959, 2103], 'PDGFRA.': [769, 961, 2105], 'IDH1,': [770, 962, 2106], 'EGFR,': [771, 963, 2107, 3947, 4037], 'NF1.Cancer': [773, 965, 2109], '2010;': [775, 967, 1072, 1235, 1790, 2111, 2395, 2442, 2511], '17:': [776, 968, 1073, 2112, 2396], '98-110Abstract': [777, 969, 2113], '(4325)': [785, 977, 2121], 'each': [789, 2675, 2693, 3636, 3751], 'shown': [790], 'unsupervised': [792], 'clustering': [793], 'profiles': [798, 1309, 2262, 2302, 2648], 'results': [799], 'three': [801, 3392, 3801, 3827, 4132], 'or': [802, 876, 1246, 1271, 1696, 1825, 1855, 1975, 2559, 2580, 2732, 3052, 3302, 3685, 3747, 3949, 3953, 3958, 4038, 4042], 'distinct': [804, 1067, 2390], 'classes.': [806], 'Epigenetic': [807], 'changes': [808], 'genetic': [810, 1116, 1244, 1342, 3913, 4031, 4123, 4145], 'mutations,': [813, 3951, 4040], 'amplifications,': [814], 'deletions': [816, 877], 'established': [818], 'suppressors': [820], 'oncogenes,': [822], 'least': [826], 'some': [827, 1086], 'identity': [830], 'GBM.': [832], 'For': [833, 1673, 3141], 'example,': [834], 'tumors,': [841], 'which': [842, 3652, 3871], 'contain': [843], 'classes,': [850, 1112], 'IDH1': [851, 3950, 4014], 'mutations': [852, 875, 4213], 'CpG': [855, 1060, 2383], 'island': [856, 1061, 2384], 'methylator': [857, 1062, 2385], 'phenotype': [858, 1063, 2317, 2386], '(G-CIMP+)': [859], 'are': [860, 878, 1107, 1298, 1310, 1494, 3153, 3396], 'seen': [861], 'almost': [862], 'exclusively': [863], 'proneural': [866, 2427, 2496, 3990], 'class,': [868, 1156, 1289], 'whereas': [869], 'nearly': [870], 'all': [871, 2668, 3563, 3853, 4108, 4238], 'NF1': [874, 4039], 'within': [879, 1813, 1830, 1936, 2268, 3635], 'class.5Verhaak': [882], '6Cancer': [980], 'NetworkComprehensive': [983, 4073], 'characterization': [985, 4075], 'defines': [986, 1065, 2388, 4076], 'human': [987, 1428, 2531, 4077], 'core': [991, 4081], 'pathways.Nature.': [992, 4082], '2008;': [993, 1910, 3454, 4083], '455:': [994, 4084], '1061-1068Crossref': [995, 4085], '(5223)': [998, 4088], '7Noushmehr': [1001], 'Weisenberger': [1003, 2326], 'D.J.': [1004, 1776, 1884, 1895, 2327, 2423, 2492, 2790, 2829, 2967, 3006, 3073, 3109, 3439, 3470, 3502], 'Diefes': [1005, 2328], 'Pujara': [1009, 2332], 'Berman': [1011, 2334], 'B.P.': [1012, 2335], 'Pan': [1013, 1756, 2336], 'F.': [1014, 1215, 1753, 2337, 3058], 'Pelloski': [1015, 2338], 'C.E.': [1016, 2339], 'Sulman': [1017, 1210, 2340], 'E.P.': [1018, 1211, 2341], 'Bhat': [1019, 2342], 'K.P.': [1020, 2343], 'Schmidt': [1029, 2352], 'H.K.': [1030, 2353], 'Van': [1035, 1768, 2358, 2784, 2825, 2961, 3002, 3069, 3114, 3466, 3505], 'Den': [1036, 2359], 'Berg': [1037, 2360], 'Shen': [1039, 2362], 'Bengtsson': [1041, 2364], 'Neuvial': [1043, 2366], 'Cope': [1045, 2368], 'L.M.': [1046, 2369], 'Buckley': [1047, 2370], 'Herman': [1049, 2372], 'Baylin': [1051, 2374], 'S.B.': [1052, 2375], 'Laird': [1053, 2376], 'P.W.': [1054, 2377], 'Identification': [1057, 2380], 'subgroup': [1068, 2391], 'glioma.Cancer': [1070, 2393], '510-522Abstract': [1074, 2397], '(1601)': [1082, 2405], 'However,': [1085], 'best': [1089], 'alterations': [1092, 1245, 3914, 4032, 4124, 4146], 'GBM,': [1094], 'TP53': [1096], 'PTEN': [1098, 2796, 2830, 2973, 3007], 'mutation,': [1099], 'EGFR': [1100, 3952, 4041], 'PDGFR': [1102], 'amplification': [1103], 'CDKN2A': [1105, 3956, 4045, 4208], 'deletion': [1106, 3957], 'noted': [1108, 4024], 'indicating': [1113], 'cell-intrinsic': [1115], 'defects': [1117], 'explain': [1120], 'patterns.': [1125], 'A': [1126, 1482, 2629], 'recent': [1127], 'classes': [1132, 3828, 3902, 4059, 4134], 'novel': [1135], 'algorithm': [1136], 'reconstruct': [1138], 'interactions': [1140], 'uncovered': [1142], 'small': [1144], 'regulate': [1150, 2833, 3010], 'transition': [1152], 'Among': [1165, 3711], 'these,': [1166], 'regulators,': [1177, 1184], 'controlling': [1178], 'other': [1182, 3800, 3826, 3901, 4020, 4057, 4131, 4239], 'key': [1183, 1473], 'accounting': [1186, 1446], 'majority': [1189], 'downstream': [1191], 'signaling': [1192, 1474], 'events': [1193], 'signature.8Carro': [1198], 'M.S.': [1199], 'Lim': [1200], 'Alvarez': [1202], 'Bollo': [1204], 'R.J.': [1205], 'Zhao': [1206], 'X.': [1207], 'Snyder': [1208], 'E.Y.': [1209], 'Anne': [1212], 'S.L.': [1213], 'Doetsch': [1214], 'Lasorella': [1218], 'Califano': [1222], 'Iavarone': [1224], 'network': [1228], 'transformation': [1231], 'tumours.Nature.': [1234], '463:': [1236], '318-325Crossref': [1237], '(821)': [1240], 'Underlying': [1243], 'pathophysiological': [1247], 'triggers': [1248], 'regulators': [1253, 1280, 1392], 'not': [1255, 1700, 1818, 2726, 3689, 3846, 3882, 3987, 4008, 4117, 4140], 'uncovered.': [1256], 'It': [1257], 'remains': [1258], 'possible': [1259], 'elements': [1261], 'microenvironment,': [1265], 'hypoxia,': [1268, 3483], 'necrosis,': [1269, 1385, 2744, 4028, 4170, 4174], 'angiogenesis,': [1270, 2474, 3748, 3934], 'inflammatory': [1272, 1932], 'cell': [1273, 2534, 2940, 2943, 3178, 3183], 'infiltrates,': [1274, 1933], 'strongly': [1276], 'impact': [1277], 'class.': [1284, 1336], 'Microenvironmental': [1285], 'contributions': [1286], 'as': [1290, 1292, 1307, 1330, 1609, 1681, 1694, 1822, 1840, 1963, 2322, 2475, 2659, 2684, 2771, 2923, 2929, 3336, 3372, 3398, 3405, 3531, 3670, 3683, 3992], 'well': [1291], 'tissue': [1294, 1430, 1569, 1584, 1596, 1687, 1801, 1808, 1832, 1968, 1982, 2798, 2834, 2975, 3011, 3082, 3676], 'sampling': [1295], 'considerations': [1296], 'intimately': [1299], 'will': [1301], 'need': [1302], 'carefully': [1305], 'considered': [1306], 'direct': [1313, 2520], 'therapies.': [1314, 1481], 'To': [1315, 3733], 'address': [1316], 'issues,': [1318], 'performed': [1320, 2583, 2767, 3174], 'integrated': [1322], 'morphological': [1323], 'microenvironmental': [1328, 3414], 'they': [1331, 4063], 'relate': [1332], 'We': [1337, 1368, 1604, 2543, 3409, 3862], 'analyzed': [1338, 3547], 'correlates': [1343], 'using': [1350, 1725, 1948, 2124, 2209, 2263, 2584, 2596, 2607, 2704, 2916, 2921, 3121, 3354, 3586, 3866], 'from': [1357, 1512, 1621, 1634, 1845, 1945, 2008, 2137, 2166, 2190, 2221, 2716, 3177, 3562, 3596, 3612, 3700, 4056, 4218, 4237], 'corresponding': [1358, 1624, 1637, 2314, 3569], 'sections': [1360, 1509, 1802, 1812, 2770], 'quality': [1363, 1563, 1671, 3549, 3664], 'assurance': [1364, 1564, 3550], 'TCGA.': [1367], 'displaying': [1380], 'transition,': [1396], 'RUNX1,': [1403], 'tightly': [1405], 'extent': [1409, 1953, 1958, 3744, 3930], 'Nonmesenchymal': [1412, 4167], 'became': [1414], 'Using': [1427], 'sections,': [1431], 'demonstrated': [1433], 'CEBP-δ': [1437], 'specifically': [1439], 'expressed': [1440, 3397], 'peri-necrotic': [1443], 'pseudopalisading': [1444], 'cells,': [1445, 1926], 'Our': [1455], 'finding': [1456], 'portends': [1466], 'prognosis': [1469], 'suggests': [1470], 'nodes': [1475], 'hold': [1477], 'potential': [1478, 3411], 'targeted': [1480], 'complete': [1483], 'description': [1484], 'samples,': [1486, 1651], 'imaging,': [1489], 'molecular,': [1490], 'pathology': [1492], 'provided': [1495], 'Supplemental': [1497], 'Tables': [1498], '1–6': [1499], '(available': [1500], 'http://ajp.amjpathol.org).': [1502], 'Whole-slide': [1503], 'obtained': [1511, 2007, 2165, 2189, 2309, 2544], 'portal': [1515, 2193], '(http://tcga-data.nci.nih.gov/tcga/tcgaHome2.jsp;': [1516, 2563], 'last': [1517, 2180, 2564, 3382], 'accessed': [1518, 2181, 2565], 'June': [1519, 2182, 2566], '6,': [1520, 2183, 2567], '2011).': [1521, 2184, 2568], 'Frozen': [1522], 'scanned': [1526], '20×': [1530], 'resolution': [1531], 'Aperio': [1534], 'scanner': [1535], 'Biospecimen': [1539], 'Core': [1540], 'Resource': [1541], 'located': [1542], 'International': [1545], 'Genomics': [1546, 2177], 'Consortium': [1547], '(Intgen,': [1548], 'Phoenix,': [1549], 'AZ).': [1550], 'those': [1556, 1841, 4092], 'reviewed': [1557, 3659], 'Intgen': [1559], 'contracted': [1560], 'neuropathologists': [1561, 1664, 2546, 3657, 3879], 'ensure': [1566], 'between': [1570, 1711, 2203, 2570, 2696, 3344, 3629, 3716, 3740, 4025], 'top': [1572], 'bottom': [1575], 'adequate': [1578], 'studies.': [1581], 'Importantly,': [1582], 'create': [1599, 2234], 'investigation.': [1603], 'our': [1610, 1703, 3692], 'source': [1612, 1644], 'annotated': [1616, 1630], '177': [1619, 3564], '99': [1622, 3571], '91': [1626, 3574], 'patients.': [1627, 1640, 3386], 'Angiogenesis': [1628, 1690, 3679], '168': [1632], '95': [1635], '88': [1639], 'As': [1641, 3554, 3642], 'secondary': [1643, 3644], 'semi-quantitative': [1654], 'annotations': [1655, 3648], '293': [1657, 3650], 'recorded': [1661, 1680, 1692, 3654, 3669, 3681], 'after': [1665], 'reviewing': [1666], 'assurance.': [1672, 3665], 'images,': [1675], 'percent': [1677, 2700, 3631, 3727, 3819], 'visual': [1683, 3672], 'estimate': [1684, 3673], 'total': [1686, 1807, 1981, 3675], 'area': [1688, 3677], 'involved.': [1689, 3678], '"present"': [1695, 3684], '"absent"': [1697], 'useful': [1701, 3690], 'There': [1705, 3623], '70': [1707, 3712], 'overlap': [1710, 3715], 'two': [1713, 1732, 3430, 3718], 'sources': [1714, 2527, 3526, 3719], 'data.': [1716], 'Regions': [1717, 1820], 'manually': [1723, 3765], 'outlined': [1724, 1804, 1829], 'ImageScope': [1726], 'software': [1727], '(Aperio,': [1728], 'Vista': [1729], 'CA)': [1730, 2458, 3309, 3333], 'pathologists': [1733], 'working': [1734], 'together': [1735], 'reaching': [1737], 'consensus': [1739], 'include': [1744], '(CA,': [1745], 'DJB).9Cooper': [1746], 'L.A.': [1747, 2409, 2478], 'Kong': [1748], 'Gutman': [1750, 2410, 2479], 'D.A.': [1751, 2411, 2480], 'Cholleti': [1754, 2416, 2485], 'S.R.': [1755, 2417, 2486], 'T.C.': [1757, 1899, 3443], 'Widener': [1758], 'Sharma': [1760], 'Mikkelsen': [1762], 'Flanders': [1764], 'A.E.': [1765], 'Rubin': [1766], 'D.L.': [1767, 2781, 2824, 2958, 3001, 3068, 3465], 'Meir': [1769, 2785, 2826, 2962, 3003, 3070, 3115, 3467, 3506], 'E.G.': [1770, 2786, 2827, 2963, 3004, 3071, 3116, 3468, 3507], 'Kurc': [1771, 2418, 2487], 'T.M.': [1772], 'Moreno': [1773, 2424, 2493], 'C.S.': [1774, 2425, 2494], 'Brat': [1775, 1883, 2422, 2491, 2789, 2828, 2966, 3005, 3072, 3108, 3469, 3501], 'Saltz': [1777, 2420, 2489], 'J.H.': [1778, 2421, 2490], 'An': [1779], 'integrative': [1780], 'approach': [1781], 'silico': [1784], 'research.IEEE': [1786], 'Trans': [1787], 'Biomed': [1788], 'Eng.': [1789], '57:': [1791], '2617-2621Crossref': [1792], '(39)': [1795], 'boundaries': [1799, 1833], 'calculate': [1806], 'area.': [1809, 1984], 'Duplicate': [1810], 'same': [1815], 'slide': [1816], 'analyzed.': [1819], 'identified': [1821, 1839], 'either': [1823, 2556], 'exhaustively': [1828], '(Figure': [1834, 3590, 3809, 3860, 4101], '1).': [1835, 3591, 4136], 'Angiogenic': [1836], 'regions': [1837, 1843, 1947, 2737], 'vascular': [1842, 3481], 'departing': [1844], 'normal,': [1846], 'exhibiting': [1848], 'characteristics': [1849], 'cellular': [1851, 1853], 'hypertrophy,': [1852], 'hyperplasia,': [1854], 'microvascular': [1856], 'proliferation.1Louis': [1857], '10Perry': [1881], 'Practical': [1885], 'pathology:': [1887], 'diagnostic': [1889], 'approach.': [1890], 'Elsevier,': [1891], 'Philadelphia2010Google': [1892], '11Brat': [1894], 'Prayson': [1896, 3440], 'R.A.': [1897, 3441], 'Ryken': [1898, 3442], 'Olson': [1900, 2782, 2959, 3444], 'J.J.': [1901, 2783, 2960, 3445], 'Diagnosis': [1902, 3446], 'malignant': [1904, 3448], 'glioma:': [1905, 3449], 'role': [1906, 3450, 3918], 'neuropathology.J': [1908, 3452], 'Neurooncol.': [1909, 3453, 3516], '89:': [1911, 3455], '287-311Crossref': [1912, 3456], '(67)': [1915, 3459], 'addition': [1919], 'endothelial': [1922], 'compartment,': [1923], 'perivascular': [1925], 'pericytes,': [1928], 'fibroblasts,': [1929], 'any': [1931], 'included': [1935], 'marked': [1937, 3577, 3766], 'angiogenic': [1938, 1946], 'regions.': [1939], 'Luminal': [1940], 'areas': [1941, 1978], 'automatically': [1943], 'subtracted': [1944], 'computer-based': [1949], 'color': [1950], 'segmentation.': [1951], 'calculated': [1962, 2606, 2658, 2683, 2703], 'percentage': [1965, 3593], 'whole': [1967], 'taking': [1970], 'ratios': [1972], 'surface': [1977], 'Areas': [1985], 'summed': [1987], 'over': [1988, 2228, 2312], 'before': [1991, 3551], 'ratio': [1992], 'calculation': [1993], 'determine': [1995, 3734, 4061], 'per-sample': [1996], 'per-patient': [1998], 'percentages.': [1999], 'Transcriptional': [2000, 2672], 'labels': [2002], 'patients': [2005, 3378], 'Advanced': [2011], 'Working': [2012], 'Group.': [2013], 'This': [2014], 'labeling': [2015], 'extends': [2016], 'original': [2018, 2139], 'labeled': [2022, 2140], 'Affymetrix': [2125, 2223], 'HT_HG-U133A': [2126], 'classify': [2129], 'previously': [2130, 2323, 2476, 2728, 2948], 'unlabeled': [2131], 'given': [2134], 'centroids': [2135], 'derived': [2136], 'set.': [2141], 'Patient-reduced': [2142], 'percentages': [2143], 'tested': [2149], 'one-way': [2156, 3833], 'variance': [2159], 'tests.': [2160], 'Copy': [2161, 4156], 'number': [2162, 4196, 4216], 'Pathway': [2169, 2451], 'Memorial': [2173], 'Sloan': [2174], 'Kettering': [2175], 'Portal': [2178], '(http://www.cbioportal.org/public-portal;': [2179], 'Level': [2185, 2212], '3': [2186], 'sequence': [2187], 'filtered': [2195], 'remove': [2197], 'silent': [2198], 'mutations.': [2199], 'Necrosis': [2200], 'compared': [2202, 3797, 3899, 4049, 4104, 4126], 'amplified/normal,': [2204], 'deleted/normal,': [2205], 'mutant/wild-type': [2207], 'two-way': [2210, 2597], 't-tests.': [2211], '2': [2213], 'robust': [2214], 'multichip': [2215], 'average': [2216, 2661], 'normalized': [2217, 2688], 'U133A': [2224], 'platform': [2225], 'averaged': [2227], 'arrays': [2232], 'patient-reduced': [2235], 'profiles.': [2237, 2671, 3368], 'Probes': [2238], 'unlogged': [2241], 'range': [2243], '<20': [2245], 'fold': [2248], 'change': [2249], '<1.5': [2251], 'removed.': [2253], 'Percentage': [2254], 'Cox': [2265], 'proportional': [2266], 'hazards': [2267], 'significance': [2270, 2466, 2537], 'microarray': [2273, 2469], 'procedure.12Tusher': [2274], 'V.G.': [2275], 'Tibshirani': [2276], 'Chu': [2278], 'Significance': [2280, 3402], 'microarrays': [2283, 2617], 'applied': [2284, 2460], 'ionizing': [2287], 'radiation': [2288, 2731], 'response.Proc': [2289], 'Natl': [2290], 'Acad': [2291], 'Sci': [2292], 'USA.': [2293], '2011;': [2294], '98:': [2295], '5116-5121Crossref': [2296], '(9446)': [2298], 'Gene-centric': [2301], 'averaging': [2311], 'probes.': [2315], 'Methylation': [2316], 'G-CIMP': [2318], 'status': [2319, 3980], 'calculated,': [2321], 'described.7Noushmehr': [2324], '13Cooper': [2408], 'Long': [2412, 2481], 'Q.': [2413, 2482], 'Johnson': [2414, 2483], 'signature': [2429, 2498, 2604, 2656, 2681], 'oligodendrogliomas': [2433, 2502], 'predicts': [2435, 2504], 'improved': [2436, 2505], 'diffuse': [2439, 2508], 'gliomas.PLoS': [2440, 2509], 'ONE.': [2441, 2510], '5:': [2443, 2512], 'e12548Crossref': [2444, 2513], '(111)': [2447, 2516], 'Ingenuity': [2450], 'Analysis': [2452, 3995], '(IPA)': [2453], '(Ingenuity': [2454], 'Systems,': [2455], 'Redwood': [2456], 'City,': [2457], 'lists': [2463], 'described.13Cooper': [2477], 'Both': [2519], 'indirect': [2522], 'relationships': [2523], 'included.': [2525], 'Data': [2526], 'restricted': [2529], 'species': [2532], 'lines.': [2535, 3184], 'Network': [2536], 'assigned': [2539], 'hypergeometric': [2541], 'scoring.': [2542], 'ratings': [2547], 'pathological': [2549, 3432], 'categories': [2550], '112': [2552], 'assignments': [2562], 'Association': [2569, 3343], 'macrophages': [2577], '(0,': [2578], '1+,': [2579], '2+)': [2581], "Fisher's": [2585], 'test.': [2586], 'Expression': [2587], 'differences': [2588], 'examined': [2595, 3353, 3750], 't-tests': [2598], 'unequal': [2600], 'variance.': [2601], 'nearest': [2611, 2619], 'centroid': [2612], 'procedure.14Dabney': [2613], 'A.R.': [2614], 'Classification': [2615], 'centroids.Bioinformatics.': [2620], '21:': [2622], '4148-4154Crossref': [2623], '(94)': [2626], '250': [2632, 2665], 'probes': [2633, 2666], 'distinguish': [2635], 'selected': [2639], 'ranking': [2641], 't-statistics': [2642], 'computed': [2643], 'comparing': [2645], 'sample-reduced': [2646], 'nonmesenchymal': [2652, 2676, 4109], 'samples.': [2653], 'sample': [2670, 2677, 3637], 'distance': [2673, 2687, 2698], 'Euclidean': [2686], 'SD': [2691], 'probe.': [2694], 'Correlation': [2695], 'Spearman': [2705], 'rank': [2706, 3357], 'correlation.': [2707], 'Ten': [2708], 'archived': [2709], 'surgically': [2710], 'resected': [2711], 'specimens': [2713], 'retrieved': [2715], 'Emory': [2717], 'University': [2718], 'Hospital': [2719], 'Department': [2720], 'Pathology.': [2722], 'had': [2725, 3785, 3815, 4064], 'been': [2727, 2947], 'treated': [2729], 'chemotherapy': [2733], 'blocks': [2735], 'foci': [2742], 'infiltrating': [2745], 'glioma,': [2746], 'non-neoplastic': [2749], 'brain.': [2750], 'tissues': [2752], 'fixed': [2754], '10%': [2756, 3228], 'buffered': [2757], 'formalin,': [2758], 'routinely': [2759], 'processed,': [2760], 'paraffin-embedded.': [2762], 'Immunohistochemical': [2763], '(IHC)': [2764], 'studies': [2765], '6-μm': [2769], 'described.15Rong': [2772, 2949], 'Belozerov': [2774, 2951], 'V.E.': [2775, 2952], 'Tucker-Burden': [2776, 2953], 'Durden': [2780, 2823, 2957, 3000, 3067, 3464], 'Mackman': [2787, 2964, 3061], 'N.': [2788, 2965, 3062], 'Epidermal': [2791, 2968], 'growth': [2792, 2969, 3075], 'factor': [2793, 2799, 2835, 2970, 2976, 3012, 3083, 3125], 'receptor': [2794, 2971, 4223], 'modulate': [2797, 2974], 'through': [2803, 2980, 3087], 'JunD/activator': [2804, 2981], 'protein-1': [2805, 2982], 'activity.Cancer': [2807, 2984], 'Res.': [2808, 2842, 2985, 3019, 3091, 3132], '2009;': [2809, 2986], '69:': [2810, 2987], '2540-2549Crossref': [2811, 2988], '(96)': [2814, 2991], '16Rong': [2817, 2994], 'Post': [2819, 2996, 3503], 'D.E.': [2820, 2997, 3101, 3504], 'Pieper': [2821, 2998], 'hypoxia': [2832, 3009, 3123, 3156, 3168], 'plasma': [2838, 3015], 'coagulation': [2839, 3016], 'glioblastoma.Cancer': [2841, 3018], '65:': [2844, 3021, 3490], '1406-1413Crossref': [2845, 3022], '(177)': [2848, 3025], 'Sections': [2851, 2933], 'deparaffinized': [2853], 'subjected': [2855], 'heat-induced': [2857], 'epitope': [2858], 'retrieval': [2859], 'steaming': [2861], '15': [2863], 'minutes.': [2864], 'Slides': [2865], 'then': [2867], 'incubated': [2868, 3237, 3250, 3294], 'antibodies': [2870, 3255, 3305], 'toward': [2872], 'Stat3': [2873, 3258], '(rabbit': [2874, 2883], 'polyclonal,': [2875, 2884], '1:100;': [2876, 2885, 2891, 2902, 2910], 'Cell': [2877, 3261, 3267, 3272], 'Signaling,': [2878], 'Beverly,': [2879], 'MA)': [2880], 'phospho-Stat3': [2882, 3264], 'Abcam,': [2886], 'Cambridge,': [2887], 'MA),': [2888], '(monoclonal,': [2890, 2901, 3259, 3281, 3326], 'Abcam),': [2892], '(polyclonal,': [2894, 2909, 3275], '1:100,': [2895], 'Novus': [2896, 2911, 3277], 'Biologicals,': [2897], 'Littleton,': [2898], 'CO),': [2899], 'CD68': [2900], 'Biocare': [2903], 'Medical,': [2904], 'Concord,': [2905], 'CA),': [2906], 'CD163': [2908], 'Biologicals).': [2912], 'Antibodies': [2913], 'detected': [2915], 'avidin-biotin-peroxidase': [2918], 'complex': [2919], 'method': [2920], '3,3′-diaminobenzidine': [2922], 'chromogen.': [2925], 'Normal': [2926], 'sera': [2927], 'served': [2928], 'negative': [2931], 'control.': [2932], 'counterstained': [2935], 'hematoxylin.': [2937], 'Human': [2938], 'line': [2941], 'U87MG': [2942], 'culture': [2944, 3039, 3146], 'conditions': [2945, 3047], 'Cells': [3028], 'experiments': [3031, 3142], 'grown': [3033], '80%': [3035], 'confluence': [3036], '100-mm': [3038], 'dishes,': [3040], 'placed': [3041, 3149], 'serum': [3043], 'free': [3044], 'media': [3045], '21%': [3049], 'O2': [3050, 3054, 3163], '(normoxia)': [3051], '1%': [3053, 3144, 3162], '(hypoxia)17Rong': [3055], 'Hu': [3057], 'Huang': [3059], 'Horowitz': [3063], 'Jensen': [3065], 'R.L.': [3066], 'Early': [3074], 'response': [3076], 'gene-1': [3077], 'regulates': [3078], 'hypoxia-induced': [3079], 'multiforme': [3086], 'hypoxia-inducible': [3088], 'factor-1-independent': [3089], 'mechanisms.Cancer': [3090], '66:': [3093], '7067-7074Crossref': [3094], '(82)': [3097], '18Post': [3100], 'Sandberg': [3102], 'E.M.': [3103], 'Kyle': [3104], 'M.M.': [3105], 'Devi': [3106], 'N.S.': [3107], 'Xu': [3110], 'Tighiouart': [3112], 'Targeted': [3117], 'cancer': [3118], 'therapy': [3120], 'inducible': [3124], 'dependent': [3126], 'oncolytic': [3127], 'adenovirus': [3128], 'armed': [3129], 'interleukin-4.Cancer': [3131], '2007;': [3133], '67:': [3134], '6872-6881Crossref': [3135], '(80)': [3138], 'Scholar.': [3140], 'O2,': [3145], 'dishes': [3147], 'incubators': [3151], 'dedicated': [3154], '(94%': [3157], 'N2,': [3158], '5%': [3159, 3246], 'CO2,': [3160], '37°C).': [3165], 'Exposure': [3166], 'lasted': [3169], '24': [3170], 'hours.': [3171], 'Immunoblots': [3172], 'proteins': [3176], 'lysates': [3179], 'NE-PER': [3186], 'Nuclear': [3187], 'Cytoplasmic': [3189], 'Extraction': [3190], 'Reagents': [3191], '(Pierce': [3192, 3322], 'Biotechnology,': [3193, 3330], 'Rockford,': [3194], 'IL)': [3195], 'separation': [3199], 'nuclear': [3201, 3341], 'cytoplasmic': [3203], 'protein': [3204, 3221], 'fractions.': [3205], 'Protein': [3206], 'concentrations': [3207], 'determined': [3209, 3936], 'Bradford': [3212], 'assay': [3213], '(Bio-Rad': [3214], 'Laboratories,': [3215], 'Hercules,': [3216, 3308], 'CA).': [3217], 'Equal': [3218], 'amounts': [3219], '(30': [3222], 'μg)': [3223], 'resolved': [3225], 'SDS-PAGE': [3229], 'transferred': [3231], 'nitrocellulose': [3233], 'membranes.': [3234], 'Blots': [3235, 3290], 'blocking': [3239], 'solution': [3240], '(PBS': [3241], 'containing': [3242], '0.02%': [3243], 'Tween-20': [3244], 'nonfat': [3247], 'milk)': [3248], 'overnight': [3251], '4°C': [3253], '1:2000,': [3260], 'Signaling)': [3262], '(monclonal,': [3265], '1:1000;': [3266], 'Signaling),': [3268, 3273], '(polycolonal,': [3270], '1:1000,': [3271, 3276, 3282], 'Biologicals),': [3278], 'HIF-1α': [3280], 'BD': [3283], 'Transduction': [3284], 'Lab,': [3285], 'Research': [3286], 'Triangle': [3287], 'Park,': [3288], 'NC).': [3289], 'washed': [3292], 'horseradish': [3296], 'peroxidase': [3297], 'conjugated': [3298], 'goat': [3300, 3303], 'anti-mouse': [3301], 'anti-rabbit': [3304], '(1:2000,': [3306], 'Bio-Rad,': [3307], 'hour': [3312], 'room': [3314], 'temperature': [3315], 'developed': [3317], 'enhanced': [3319], 'chemiluminescence': [3320], 'reagents': [3321], 'Biotechnology).': [3323], 'Histone': [3324], 'H1': [3325], '1:4000;': [3327], 'Santa': [3328, 3331], 'Cruz': [3329], 'Cruz,': [3332], 'loading': [3337], 'control': [3338], 'compartment.': [3342], 'log': [3356], 'test': [3358], 'compare': [3360], 'upper': [3362], 'lower': [3364], 'quartiles': [3365], 'gene-centric': [3367], 'Survival': [3369], 'taken': [3371], '"days': [3373, 3380], 'death"': [3375], 'uncensored': [3377], 'follow-up"': [3383], 'right-censored': [3385], 'All': [3387], 'qualitative': [3388], 'repeated': [3391], 'times.': [3393], 'Quantitative': [3394], '±': [3400, 3605, 3621, 3709, 3822, 3831], 'SEM.': [3401], 'defined': [3404], 'P': [3406, 3837, 3907, 3983], '<': [3407], '0.05.': [3408], 'investigated': [3410], 'correlation': [3412, 3739], 'patterns,': [3423], 'primarily': [3426], 'dominant': [3431], 'findings': [3433, 3865], 'GBM:': [3435], 'angiogenesis.11Brat': [3438], '19Rong': [3462], '"Pseudopalisading"': [3471], 'glioblastoma:': [3474], 'familiar': [3476], 'morphologic': [3477], 'feature': [3478], 'links': [3480], 'pathology,': [3482], 'angiogenesis.J': [3485], 'Neuropathol': [3486], 'Exp': [3487], 'Neurol.': [3488], '529-539Crossref': [3491], '(357)': [3494], '20Kaur': [3497], 'Tan': [3499], 'Genetic': [3508], 'hypoxic': [3510], 'regulation': [3511], 'gliomas.J': [3515], '2004;': [3517], '70:': [3518], '229-243Crossref': [3519], '(121)': [3522], 'Two': [3525], 'measures': [3532], 'source,': [3557, 3645], 'downloaded': [3559], 'available': [3565], 'slides,': [3568], 'patients,': [3575], 'up': [3578], 'computer-human': [3588], 'interface': [3589], 'varied': [3595, 3611, 3699], '0': [3597, 3613, 3701], '84.7%': [3599], '13.6': [3604], '1.9%.': [3606], '13.7%': [3615], '1.4': [3620], '0.2%.': [3622], 'weak': [3626], 'positive': [3627], 'relationship': [3628], "(Spearman's": [3638, 3729], 'rho': [3639, 3730], '=': [3640, 3731, 3838, 3908, 3984], '0.29).': [3641], 'who': [3658], 'Percent': [3666, 3694], '"absent,"': [3686], 'cases': [3698, 3793, 3805, 4003], '87.5%': [3703], '14.5': [3708], '1.6%.': [3710], 'there': [3722, 3736, 4138], 'strong': [3724], 'agreement': [3725], '0.71).': [3732], 'whether': [3735, 4062], 'distributions': [3755], 'features.': [3758], '85': [3763], '(31%': [3791], '>25%': [3795, 3807], 'necrosis)': [3796, 3808], '(0': [3804], '1C).': [3810], 'higher': [3817], '(21.5': [3821], '4.5%)': [3823], 'than': [3824, 4232], 'combined': [3829], '(6.9': [3830], '0.9%;': [3832], 'variance;': [3836, 3906], '8.7': [3839], '×': [3840, 3910], '10−4).': [3841], 'Extent': [3842], 'subtype,': [3851], 'yet': [3852], 'extreme': [3854], 'outliers': [3855, 4100], '(angiogenesis': [3856], '>8%)': [3857], '1F).': [3861], 'validated': [3863], 'visually': [3873], 'estimated': [3874], '(291': [3880], 'samples;': [3881], 'shown).': [3883], 'set,': [3886], '(one-way': [3903], '6.9': [3909], '10−5).': [3911], 'play': [3916], 'if': [3937], 'level': [3939], 'TP53,': [3945, 4220], 'PTEN,': [3946, 4036], 'NF1,': [3948], 'PDGFRA': [3954, 4043, 4204], 'amplification,': [3955, 4044], 'G-CIMP+': [3959, 3979], 'status.': [3960], '189': [3964], 'DNA': [3967], 'methylation': [3968], 'low': [3973], '(two-way': [3981], 't-test;': [3982], '0.0064),': [3985], 'but': [3986], 'whole.': [3994], 'limited': [3999], '114': [4002], 'mutation': [4005], 'did': [4007, 4116], 'reveal': [4009], 'significant': [4011, 4021], 'mutants': [4015], 'wild-type': [4017], 'cases.': [4018], 'No': [4019], 'correlations': [4022], 'frequent': [4030], '(TP53,': [4035], 'deletion).': [4046], 'Next': [4047], 'extremely': [4050], 'necrotic': [4051, 4113, 4151], 'distinctive': [4066], 'spectrum': [4067], 'alterations.6Cancer': [4070], 'mesechnymal': [4093], '>40%': [4096], 'represented': [4098], '1C),': [4102], 'subset': [4106], 'GBMs.': [4110], 'outlying': [4112], 'harbor': [4118], 'particular': [4120], 'when': [4125], '(Table': [4135], 'Thus,': [4137], 'defining': [4142], 'highly': [4150], 'cases.Table': [4153], '1Mutation': [4154], 'Number': [4157], 'Alterations': [4158], 'Highly': [4160], 'Necrotic': [4161], 'Compared': [4163], 'Low': [4165], 'Necrosis,': [4166], 'GBMsGenes': [4168], 'mutatedHigh': [4169], 'MS;': [4171], 'n': [4172, 4176], '(%)Low': [4173], 'non-MS;': [4175], '(%)TP531/4': [4177], '(25)15/70': [4178], '(21.4)PTEN0/4': [4179], '(0)14/70': [4180], '(20.0)NF11/4': [4181], '(25)3/70': [4182, 4192], '(4.3)EGFR1/4': [4183], '(25)14/70': [4184], '(20)ERBB20/4': [4185], '(0)5/70': [4186], '(7.1)RB10/4': [4187], '(0)4/70': [4188], '(5.7)PIK3R10/4': [4189], '(0)10/70': [4190], '(14.3)PIK3CA1/4': [4191], '(4.3)IDH10/4': [4193], '(0)7/70': [4194], '(10.0)Copy': [4195], 'alterationsn': [4197], '(%)n': [4198], '(%)': [4199], 'EFGR': [4200], 'amplification3/4': [4201], '(75)50/66': [4202], '(75.8)': [4203], 'amplification1/4': [4205], '(25)12/66': [4206], '(18.2)': [4207], 'deletion2/4': [4209], '(50)2/66': [4210], '(63.6)Frequency': [4211], 'copy': [4215], 'variation': [4217], 'RB,': [4221, 4245], 'tyrosine': [4224], 'kinase': [4225], 'pathways': [4226], 'MS': [4228], '40%': [4233], 'classes.GBMs,': [4241], 'glioblastomas;': [4242], 'MS,': [4243], 'mesenchymal;': [4244], 'retinoblastoma.': [4246], 'Open': [4247], 'table': [4248], 'new': [4251], 'tab': [4252]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2097486055', 'counts_by_year': [{'year': 2024, 'cited_by_count': 11}, {'year': 2023, 'cited_by_count': 14}, {'year': 2022, 'cited_by_count': 16}, {'year': 2021, 'cited_by_count': 38}, {'year': 2020, 'cited_by_count': 35}, {'year': 2019, 'cited_by_count': 13}, {'year': 2018, 'cited_by_count': 11}, {'year': 2017, 'cited_by_count': 20}, {'year': 2016, 'cited_by_count': 14}, {'year': 2015, 'cited_by_count': 15}, {'year': 2014, 'cited_by_count': 10}, {'year': 2013, 'cited_by_count': 13}, {'year': 2012, 'cited_by_count': 6}], 'updated_date': '2024-12-10T16:14:47.454907', 'created_date': '2016-06-24'}