Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2096795721', 'doi': 'https://doi.org/10.1158/1535-7163.mct-13-0208', 'title': 'Inhibition of ABCB1 Expression Overcomes Acquired Docetaxel Resistance in Prostate Cancer', 'display_name': 'Inhibition of ABCB1 Expression Overcomes Acquired Docetaxel Resistance in Prostate Cancer', 'publication_year': 2013, 'publication_date': '2013-07-17', 'ids': {'openalex': 'https://openalex.org/W2096795721', 'doi': 'https://doi.org/10.1158/1535-7163.mct-13-0208', 'mag': '2096795721', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/23861346', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/3947549'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1158/1535-7163.mct-13-0208', 'pdf_url': 'https://mct.aacrjournals.org/content/molcanther/12/9/1829.full.pdf', 'source': {'id': 'https://openalex.org/S48437117', 'display_name': 'Molecular Cancer Therapeutics', 'issn_l': '1535-7163', 'issn': ['1535-7163', '1538-8514'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://mct.aacrjournals.org/content/molcanther/12/9/1829.full.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5109567068', 'display_name': 'Yezi Zhu', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I84218800', 'display_name': 'University of California, Davis', 'ror': 'https://ror.org/05rrcem69', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I84218800']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Yezi Zhu', 'raw_affiliation_strings': ["Authors' Affiliations:\u20081Department of Urology, 2Graduate Program in Pharmacology and Toxicology, 3Comprehensive Cancer Center, University of California at Davis, Sacramento, California"], 'affiliations': [{'raw_affiliation_string': "Authors' Affiliations:\u20081Department of Urology, 2Graduate Program in Pharmacology and Toxicology, 3Comprehensive Cancer Center, University of California at Davis, Sacramento, California", 'institution_ids': ['https://openalex.org/I84218800', 'https://openalex.org/I84218800']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101592945', 'display_name': 'Chengfei Liu', 'orcid': 'https://orcid.org/0000-0002-2452-8788'}, 'institutions': [{'id': 'https://openalex.org/I84218800', 'display_name': 'University of California, Davis', 'ror': 'https://ror.org/05rrcem69', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I84218800']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Chengfei Liu', 'raw_affiliation_strings': ["Authors' Affiliations:\u20081Department of Urology, 2Graduate Program in Pharmacology and Toxicology, 3Comprehensive Cancer Center, University of California at Davis, Sacramento, California"], 'affiliations': [{'raw_affiliation_string': "Authors' Affiliations:\u20081Department of Urology, 2Graduate Program in Pharmacology and Toxicology, 3Comprehensive Cancer Center, University of California at Davis, Sacramento, California", 'institution_ids': ['https://openalex.org/I84218800']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5070199787', 'display_name': 'Nagalakshmi Nadiminty', 'orcid': 'https://orcid.org/0000-0003-3408-3206'}, 'institutions': [{'id': 'https://openalex.org/I84218800', 'display_name': 'University of California, Davis', 'ror': 'https://ror.org/05rrcem69', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I84218800']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Nagalakshmi Nadiminty', 'raw_affiliation_strings': ["Authors' Affiliations:\u20081Department of Urology, 2Graduate Program in Pharmacology and Toxicology, 3Comprehensive Cancer Center, University of California at Davis, Sacramento, California"], 'affiliations': [{'raw_affiliation_string': "Authors' Affiliations:\u20081Department of Urology, 2Graduate Program in Pharmacology and Toxicology, 3Comprehensive Cancer Center, University of California at Davis, Sacramento, California", 'institution_ids': ['https://openalex.org/I84218800']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5012734277', 'display_name': 'Wei Lou', 'orcid': 'https://orcid.org/0000-0002-4688-1216'}, 'institutions': [{'id': 'https://openalex.org/I84218800', 'display_name': 'University of California, Davis', 'ror': 'https://ror.org/05rrcem69', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I84218800']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Wei Lou', 'raw_affiliation_strings': ["Authors' Affiliations:\u20081Department of Urology, 2Graduate Program in Pharmacology and Toxicology, 3Comprehensive Cancer Center, University of California at Davis, Sacramento, California"], 'affiliations': [{'raw_affiliation_string': "Authors' Affiliations:\u20081Department of Urology, 2Graduate Program in Pharmacology and Toxicology, 3Comprehensive Cancer Center, University of California at Davis, Sacramento, California", 'institution_ids': ['https://openalex.org/I84218800']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5070783001', 'display_name': 'Ramakumar Tummala', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I84218800', 'display_name': 'University of California, Davis', 'ror': 'https://ror.org/05rrcem69', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I84218800']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Ramakumar Tummala', 'raw_affiliation_strings': ["Authors' Affiliations:\u20081Department of Urology, 2Graduate Program in Pharmacology and Toxicology, 3Comprehensive Cancer Center, University of California at Davis, Sacramento, California"], 'affiliations': [{'raw_affiliation_string': "Authors' Affiliations:\u20081Department of Urology, 2Graduate Program in Pharmacology and Toxicology, 3Comprehensive Cancer Center, University of California at Davis, Sacramento, California", 'institution_ids': ['https://openalex.org/I84218800']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5088621070', 'display_name': 'Christopher P. Evans', 'orcid': 'https://orcid.org/0000-0001-5626-8901'}, 'institutions': [{'id': 'https://openalex.org/I84218800', 'display_name': 'University of California, Davis', 'ror': 'https://ror.org/05rrcem69', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I84218800']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Christopher P. Evans', 'raw_affiliation_strings': ["Authors' Affiliations:\u20081Department of Urology, 2Graduate Program in Pharmacology and Toxicology, 3Comprehensive Cancer Center, University of California at Davis, Sacramento, California"], 'affiliations': [{'raw_affiliation_string': "Authors' Affiliations:\u20081Department of Urology, 2Graduate Program in Pharmacology and Toxicology, 3Comprehensive Cancer Center, University of California at Davis, Sacramento, California", 'institution_ids': ['https://openalex.org/I84218800', 'https://openalex.org/I84218800']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5048369552', 'display_name': 'Allen C. Gao', 'orcid': 'https://orcid.org/0000-0002-5966-9038'}, 'institutions': [{'id': 'https://openalex.org/I84218800', 'display_name': 'University of California, Davis', 'ror': 'https://ror.org/05rrcem69', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I84218800']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Allen C. Gao', 'raw_affiliation_strings': ["Authors' Affiliations:\u20081Department of Urology, 2Graduate Program in Pharmacology and Toxicology, 3Comprehensive Cancer Center, University of California at Davis, Sacramento, California"], 'affiliations': [{'raw_affiliation_string': "Authors' Affiliations:\u20081Department of Urology, 2Graduate Program in Pharmacology and Toxicology, 3Comprehensive Cancer Center, University of California at Davis, Sacramento, California", 'institution_ids': ['https://openalex.org/I84218800', 'https://openalex.org/I84218800', 'https://openalex.org/I84218800']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 4.082, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 109, 'citation_normalized_percentile': {'value': 0.907935, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '12', 'issue': '9', 'first_page': '1829', 'last_page': '1836'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10570', 'display_name': 'Drug Transport and Resistance Mechanisms', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10570', 'display_name': 'Drug Transport and Resistance Mechanisms', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12059', 'display_name': 'Berberine and alkaloids research', 'score': 0.9962, 'subfield': {'id': 'https://openalex.org/subfields/2736', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11618', 'display_name': 'Cholesterol and Lipid Metabolism', 'score': 0.9961, 'subfield': {'id': 'https://openalex.org/subfields/2746', 'display_name': 'Surgery'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [], 'concepts': [{'id': 'https://openalex.org/C2781190966', 'wikidata': 'https://www.wikidata.org/wiki/Q420436', 'display_name': 'Docetaxel', 'level': 3, 'score': 0.98914}, {'id': 'https://openalex.org/C2780192828', 'wikidata': 'https://www.wikidata.org/wiki/Q181257', 'display_name': 'Prostate cancer', 'level': 3, 'score': 0.8248927}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.5703514}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.51346546}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.4830004}, {'id': 'https://openalex.org/C173396325', 'wikidata': 'https://www.wikidata.org/wiki/Q1501275', 'display_name': 'Gene knockdown', 'level': 3, 'score': 0.4367656}, {'id': 'https://openalex.org/C127561419', 'wikidata': 'https://www.wikidata.org/wiki/Q224527', 'display_name': 'Downregulation and upregulation', 'level': 3, 'score': 0.4364942}, {'id': 'https://openalex.org/C143998085', 'wikidata': 'https://www.wikidata.org/wiki/Q162555', 'display_name': 'Oncology', 'level': 1, 'score': 0.37393457}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.36823863}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.35364553}, {'id': 'https://openalex.org/C190283241', 'wikidata': 'https://www.wikidata.org/wiki/Q14599311', 'display_name': 'Apoptosis', 'level': 2, 'score': 0.33313107}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.29257816}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.18199524}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.07169792}], 'mesh': [{'descriptor_ui': 'D018528', 'descriptor_name': 'ATP-Binding Cassette Transporters', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D047310', 'descriptor_name': 'Apigenin', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D064129', 'descriptor_name': 'Prostatic Neoplasms, Castration-Resistant', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D043823', 'descriptor_name': 'Taxoids', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D000074063', 'descriptor_name': 'ATP Binding Cassette Transporter, Subfamily D, Member 1', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018528', 'descriptor_name': 'ATP-Binding Cassette Transporters', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D018528', 'descriptor_name': 'ATP-Binding Cassette Transporters', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D047310', 'descriptor_name': 'Apigenin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D047310', 'descriptor_name': 'Apigenin', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D045744', 'descriptor_name': 'Cell Line, Tumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000077143', 'descriptor_name': 'Docetaxel', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019008', 'descriptor_name': 'Drug Resistance, Neoplasm', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015972', 'descriptor_name': 'Gene Expression Regulation, Neoplastic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D058990', 'descriptor_name': 'Molecular Targeted Therapy', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009364', 'descriptor_name': 'Neoplasm Recurrence, Local', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D064129', 'descriptor_name': 'Prostatic Neoplasms, Castration-Resistant', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D064129', 'descriptor_name': 'Prostatic Neoplasms, Castration-Resistant', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D064129', 'descriptor_name': 'Prostatic Neoplasms, Castration-Resistant', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D043823', 'descriptor_name': 'Taxoids', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D043823', 'descriptor_name': 'Taxoids', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 6, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1158/1535-7163.mct-13-0208', 'pdf_url': 'https://mct.aacrjournals.org/content/molcanther/12/9/1829.full.pdf', 'source': {'id': 'https://openalex.org/S48437117', 'display_name': 'Molecular Cancer Therapeutics', 'issn_l': '1535-7163', 'issn': ['1535-7163', '1538-8514'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.escholarship.org/uc/item/6sh9520g', 'pdf_url': 'https://escholarship.org/content/qt6sh9520g/qt6sh9520g.pdf?t=pcq8e7', 'source': {'id': 'https://openalex.org/S4306400115', 'display_name': 'eScholarship (California Digital Library)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I2801248553', 'host_organization_name': 'California Digital Library', 'host_organization_lineage': ['https://openalex.org/I2801248553'], 'host_organization_lineage_names': ['California Digital Library'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc3947549', 'pdf_url': 'https://europepmc.org/articles/pmc3947549?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3947549', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1158/1535-7163.22500234', 'pdf_url': 'https://aacr.figshare.com/articles/journal_contribution/Supplementary_Figure_1_from_Inhibition_of_ABCB1_Expression_Overcomes_Acquired_Docetaxel_Resistance_in_Prostate_Cancer/22500234/1/files/39959511.pdf', 'source': None, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/23861346', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1158/1535-7163.mct-13-0208', 'pdf_url': 'https://mct.aacrjournals.org/content/molcanther/12/9/1829.full.pdf', 'source': {'id': 'https://openalex.org/S48437117', 'display_name': 'Molecular Cancer Therapeutics', 'issn_l': '1535-7163', 'issn': ['1535-7163', '1538-8514'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being', 'score': 0.87}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 34, 'referenced_works': ['https://openalex.org/W1592927823', 'https://openalex.org/W1965053172', 'https://openalex.org/W1967596383', 'https://openalex.org/W1971579914', 'https://openalex.org/W1977841967', 'https://openalex.org/W1986508603', 'https://openalex.org/W2005958584', 'https://openalex.org/W2006434892', 'https://openalex.org/W2012928164', 'https://openalex.org/W2013611824', 'https://openalex.org/W2018817270', 'https://openalex.org/W2020267283', 'https://openalex.org/W2020579083', 'https://openalex.org/W2021860894', 'https://openalex.org/W2029712420', 'https://openalex.org/W2034979953', 'https://openalex.org/W2045631507', 'https://openalex.org/W2050780022', 'https://openalex.org/W2051410494', 'https://openalex.org/W2055904567', 'https://openalex.org/W2062799946', 'https://openalex.org/W2074951329', 'https://openalex.org/W2098086229', 'https://openalex.org/W2106572206', 'https://openalex.org/W2107417411', 'https://openalex.org/W2120703739', 'https://openalex.org/W2131878763', 'https://openalex.org/W2135708499', 'https://openalex.org/W2139216034', 'https://openalex.org/W2148365177', 'https://openalex.org/W2148408457', 'https://openalex.org/W2157756773', 'https://openalex.org/W2166976605', 'https://openalex.org/W3143611420'], 'related_works': ['https://openalex.org/W4247833810', 'https://openalex.org/W4242240318', 'https://openalex.org/W3127487613', 'https://openalex.org/W3048105303', 'https://openalex.org/W2904239912', 'https://openalex.org/W2515537233', 'https://openalex.org/W236807388', 'https://openalex.org/W2201793188', 'https://openalex.org/W2081815287', 'https://openalex.org/W1968932537'], 'abstract_inverted_index': {'Abstract': [0], 'Docetaxel': [1], 'is': [2], 'the': [3, 17, 25, 84, 93, 105, 143], 'first-line': [4], 'standard': [5], 'treatment': [6, 128], 'for': [7, 46], 'castration-resistant': [8, 39], 'prostate': [9, 34, 41, 152, 182], 'cancer.': [10], 'However,': [11], 'relapse': [12], 'eventually': [13], 'occurs': [14], 'due': [15], 'to': [16, 21, 83, 126, 155, 179, 185], 'development': [18, 106], 'of': [19, 27, 65, 67, 70, 102, 107, 113, 142, 164], 'resistance': [20, 109, 169], 'docetaxel.': [22], 'To': [23], 'unravel': [24], 'mechanism': [26], 'acquired': [28, 167], 'docetaxel': [29, 47, 108, 127, 156, 168, 186], 'resistance,': [30], 'we': [31, 135], 'established': [32], 'docetaxel-resistant': [33, 123, 151, 181], 'cancer': [35, 42, 153, 183], 'cells,': [36], 'TaxR,': [37], 'from': [38], 'C4-2B': [40, 57], 'cells.': [43, 58, 99], 'The': [44, 100], 'IC50': [45], 'in': [48, 97, 104], 'TaxR': [49, 98, 124], 'cells': [50, 125, 154, 184], 'was': [51, 90, 110], 'about': [52], '70-fold': [53], 'higher': [54], 'than': [55], 'parental': [56], 'Global': [59], 'gene': [60], 'expression': [61, 66, 115, 148, 173], 'analysis': [62], 'revealed': [63], 'alteration': [64], 'a': [68, 139, 176], 'total': [69], '1,604': [71], 'genes,': [72], 'with': [73], '52%': [74], 'being': [75], 'upregulated': [76, 95], 'and': [77, 149, 170], '48%': [78], 'downregulated.': [79], 'ABCB1,': [80], 'which': [81], 'belongs': [82], 'ATP-binding': [85], 'cassette': [86], '(ABC)': [87], 'transporter': [88], 'family,': [89, 145], 'identified': [91, 136], 'among': [92], 'top': [94], 'genes': [96], 'role': [101], 'ABCB1': [103, 114, 147, 165, 172], 'examined.': [111], 'Knockdown': [112], 'by': [116, 129], 'its': [117], 'specific': [118], 'shRNA': [119], 'or': [120], 'inhibitor': [121], 'resensitized': [122], 'enhancing': [130], 'apoptotic': [131], 'cell': [132], 'death.': [133], 'Furthermore,': [134], 'that': [137, 162], 'apigenin,': [138], 'natural': [140], 'product': [141], 'flavone': [144], 'inhibits': [146], 'resensitizes': [150], 'treatment.': [157, 187], 'Collectively,': [158], 'these': [159], 'results': [160], 'suggest': [161], 'overexpression': [163], 'mediates': [166], 'targeting': [171], 'could': [174], 'be': [175], 'potential': [177], 'approach': [178], 'resensitize': [180], 'Mol': [188], 'Cancer': [189], 'Ther;': [190], '12(9);': [191], '1829–36.': [192], '©2013': [193], 'AACR.': [194]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2096795721', 'counts_by_year': [{'year': 2024, 'cited_by_count': 14}, {'year': 2023, 'cited_by_count': 9}, {'year': 2022, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 12}, {'year': 2020, 'cited_by_count': 12}, {'year': 2019, 'cited_by_count': 12}, {'year': 2018, 'cited_by_count': 8}, {'year': 2017, 'cited_by_count': 11}, {'year': 2016, 'cited_by_count': 9}, {'year': 2015, 'cited_by_count': 16}, {'year': 2014, 'cited_by_count': 2}], 'updated_date': '2024-12-20T17:26:37.333639', 'created_date': '2016-06-24'}