Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2096607288', 'doi': 'https://doi.org/10.1517/14656566.3.12.1739', 'title': 'Myocet (liposome-encapsulated doxorubicin citrate): a new approach in breast cancer therapy', 'display_name': 'Myocet (liposome-encapsulated doxorubicin citrate): a new approach in breast cancer therapy', 'publication_year': 2002, 'publication_date': '2002-12-01', 'ids': {'openalex': 'https://openalex.org/W2096607288', 'doi': 'https://doi.org/10.1517/14656566.3.12.1739', 'mag': '2096607288', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/12472371'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1517/14656566.3.12.1739', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S52020611', 'display_name': 'Expert Opinion on Pharmacotherapy', 'issn_l': '1465-6566', 'issn': ['1465-6566', '1744-7666'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320547', 'host_organization_name': 'Taylor & Francis', 'host_organization_lineage': ['https://openalex.org/P4310320547'], 'host_organization_lineage_names': ['Taylor & Francis'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5029097581', 'display_name': 'Gerald Batist', 'orcid': 'https://orcid.org/0000-0001-5430-3750'}, 'institutions': [{'id': 'https://openalex.org/I5023651', 'display_name': 'McGill University', 'ror': 'https://ror.org/01pxwe438', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I5023651']}, {'id': 'https://openalex.org/I2801824472', 'display_name': 'Jewish General Hospital', 'ror': 'https://ror.org/056jjra10', 'country_code': 'CA', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2801824472']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Gerald Batist', 'raw_affiliation_strings': ['Jewish General Hospital, McGill University, 3755 Cote St Catherine, Montreal, PQ, H3T 1E2 Canada, Fax: +1 514 340 7916, E-mail: [email protected]'], 'affiliations': [{'raw_affiliation_string': 'Jewish General Hospital, McGill University, 3755 Cote St Catherine, Montreal, PQ, H3T 1E2 Canada, Fax: +1 514 340 7916, E-mail: [email protected]', 'institution_ids': ['https://openalex.org/I5023651', 'https://openalex.org/I2801824472']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5026378974', 'display_name': 'Jeremy Barton', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210156614', 'display_name': 'Evgen Pharma (United Kingdom)', 'ror': 'https://ror.org/05b6k3g41', 'country_code': 'GB', 'type': 'company', 'lineage': ['https://openalex.org/I4210156614']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Jeremy Barton', 'raw_affiliation_strings': ['Elan Pharma Ltd, Abel Smith House, Gunnels Wood Road, Stevenage, Herts, SG1 2FG, UK'], 'affiliations': [{'raw_affiliation_string': 'Elan Pharma Ltd, Abel Smith House, Gunnels Wood Road, Stevenage, Herts, SG1 2FG, UK', 'institution_ids': ['https://openalex.org/I4210156614']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5036000774', 'display_name': 'Philip Chaikin', 'orcid': 'https://orcid.org/0000-0001-5745-4140'}, 'institutions': [{'id': 'https://openalex.org/I4210156614', 'display_name': 'Evgen Pharma (United Kingdom)', 'ror': 'https://ror.org/05b6k3g41', 'country_code': 'GB', 'type': 'company', 'lineage': ['https://openalex.org/I4210156614']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Philip Chaikin', 'raw_affiliation_strings': ['Elan Pharma Ltd, Abel Smith House, Gunnels Wood Road, Stevenage, Herts, SG1 2FG, UK'], 'affiliations': [{'raw_affiliation_string': 'Elan Pharma Ltd, Abel Smith House, Gunnels Wood Road, Stevenage, Herts, SG1 2FG, UK', 'institution_ids': ['https://openalex.org/I4210156614']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5067694584', 'display_name': 'Christine E. Swenson', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I20089843', 'display_name': 'Princeton University', 'ror': 'https://ror.org/00hx57361', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I20089843']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Christine Swenson', 'raw_affiliation_strings': ['Elan Pharmaceuticals, Inc, One Research Way, Princeton, NJ 08540, USA.'], 'affiliations': [{'raw_affiliation_string': 'Elan Pharmaceuticals, Inc, One Research Way, Princeton, NJ 08540, USA.', 'institution_ids': ['https://openalex.org/I20089843']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5051632521', 'display_name': 'Lauri Welles', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I2801824472', 'display_name': 'Jewish General Hospital', 'ror': 'https://ror.org/056jjra10', 'country_code': 'CA', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2801824472']}, {'id': 'https://openalex.org/I5023651', 'display_name': 'McGill University', 'ror': 'https://ror.org/01pxwe438', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I5023651']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Lauri Welles', 'raw_affiliation_strings': ['Jewish General Hospital, McGill University, 3755 Cote St Catherine, Montreal, PQ, H3T 1E2 Canada, Fax: +1 514 340 7916, E-mail: [email protected]'], 'affiliations': [{'raw_affiliation_string': 'Jewish General Hospital, McGill University, 3755 Cote St Catherine, Montreal, PQ, H3T 1E2 Canada, Fax: +1 514 340 7916, E-mail: [email protected]', 'institution_ids': ['https://openalex.org/I2801824472', 'https://openalex.org/I5023651']}]}], 'institution_assertions': [], 'countries_distinct_count': 3, 'institutions_distinct_count': 4, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.369, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 152, 'citation_normalized_percentile': {'value': 0.881807, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 97, 'max': 98}, 'biblio': {'volume': '3', 'issue': '12', 'first_page': '1739', 'last_page': '1751'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11752', 'display_name': 'Chemotherapy-Induced Peripheral Neuropathy in Cancer Treatment', 'score': 0.9972, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11752', 'display_name': 'Chemotherapy-Induced Peripheral Neuropathy in Cancer Treatment', 'score': 0.9972, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11535', 'display_name': 'Cardiotoxicity of Cancer Treatments', 'score': 0.9856, 'subfield': {'id': 'https://openalex.org/subfields/2705', 'display_name': 'Cardiology and Cardiovascular Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10074', 'display_name': 'Carbon Nanotubes and their Applications', 'score': 0.9847, 'subfield': {'id': 'https://openalex.org/subfields/2505', 'display_name': 'Materials Chemistry'}, 'field': {'id': 'https://openalex.org/fields/25', 'display_name': 'Materials Science'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/therapeutic-index', 'display_name': 'Therapeutic index', 'score': 0.7255132}, {'id': 'https://openalex.org/keywords/metastatic-breast-cancer', 'display_name': 'Metastatic Breast Cancer', 'score': 0.524879}, {'id': 'https://openalex.org/keywords/doxorubicin', 'display_name': 'Doxorubicin', 'score': 0.503471}, {'id': 'https://openalex.org/keywords/cumulative-dose', 'display_name': 'Cumulative dose', 'score': 0.46555334}, {'id': 'https://openalex.org/keywords/cardiotoxicity', 'display_name': 'Cardiotoxicity', 'score': 0.43071926}, {'id': 'https://openalex.org/keywords/therapeutic-effect', 'display_name': 'Therapeutic effect', 'score': 0.41002917}], 'concepts': [{'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.93032813}, {'id': 'https://openalex.org/C2781303535', 'wikidata': 'https://www.wikidata.org/wiki/Q18936', 'display_name': 'Doxorubicin', 'level': 3, 'score': 0.90392387}, {'id': 'https://openalex.org/C19831878', 'wikidata': 'https://www.wikidata.org/wiki/Q659446', 'display_name': 'Therapeutic index', 'level': 3, 'score': 0.7255132}, {'id': 'https://openalex.org/C2775930923', 'wikidata': 'https://www.wikidata.org/wiki/Q12859063', 'display_name': 'Metastatic breast cancer', 'level': 4, 'score': 0.54673344}, {'id': 'https://openalex.org/C530470458', 'wikidata': 'https://www.wikidata.org/wiki/Q128581', 'display_name': 'Breast cancer', 'level': 3, 'score': 0.5162387}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.48242983}, {'id': 'https://openalex.org/C151032500', 'wikidata': 'https://www.wikidata.org/wiki/Q5194182', 'display_name': 'Cumulative dose', 'level': 2, 'score': 0.46555334}, {'id': 'https://openalex.org/C2776802502', 'wikidata': 'https://www.wikidata.org/wiki/Q417589', 'display_name': 'Anthracycline', 'level': 4, 'score': 0.44899836}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.43880633}, {'id': 'https://openalex.org/C2778233292', 'wikidata': 'https://www.wikidata.org/wiki/Q2118956', 'display_name': 'Cardiotoxicity', 'level': 3, 'score': 0.43071926}, {'id': 'https://openalex.org/C185154212', 'wikidata': 'https://www.wikidata.org/wiki/Q410454', 'display_name': 'Liposome', 'level': 2, 'score': 0.42658868}, {'id': 'https://openalex.org/C102652120', 'wikidata': 'https://www.wikidata.org/wiki/Q2419430', 'display_name': 'Therapeutic effect', 'level': 2, 'score': 0.41002917}, {'id': 'https://openalex.org/C2776694085', 'wikidata': 'https://www.wikidata.org/wiki/Q974135', 'display_name': 'Chemotherapy', 'level': 2, 'score': 0.40523452}, {'id': 'https://openalex.org/C143998085', 'wikidata': 'https://www.wikidata.org/wiki/Q162555', 'display_name': 'Oncology', 'level': 1, 'score': 0.38684827}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.35534638}, {'id': 'https://openalex.org/C2780035454', 'wikidata': 'https://www.wikidata.org/wiki/Q8386', 'display_name': 'Drug', 'level': 2, 'score': 0.29677725}, {'id': 'https://openalex.org/C192562407', 'wikidata': 'https://www.wikidata.org/wiki/Q228736', 'display_name': 'Materials science', 'level': 0, 'score': 0.0}, {'id': 'https://openalex.org/C171250308', 'wikidata': 'https://www.wikidata.org/wiki/Q11468', 'display_name': 'Nanotechnology', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D001943', 'descriptor_name': 'Breast Neoplasms', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D004317', 'descriptor_name': 'Doxorubicin', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': 'Q000009', 'qualifier_name': 'adverse effects', 'is_major_topic': False}, {'descriptor_ui': 'D001943', 'descriptor_name': 'Breast Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002986', 'descriptor_name': 'Clinical Trials as Topic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004317', 'descriptor_name': 'Doxorubicin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004317', 'descriptor_name': 'Doxorubicin', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D004317', 'descriptor_name': 'Doxorubicin', 'qualifier_ui': 'Q000009', 'qualifier_name': 'adverse effects', 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008081', 'descriptor_name': 'Liposomes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1517/14656566.3.12.1739', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S52020611', 'display_name': 'Expert Opinion on Pharmacotherapy', 'issn_l': '1465-6566', 'issn': ['1465-6566', '1744-7666'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320547', 'host_organization_name': 'Taylor & Francis', 'host_organization_lineage': ['https://openalex.org/P4310320547'], 'host_organization_lineage_names': ['Taylor & Francis'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/12472371', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'score': 0.87, 'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 66, 'referenced_works': ['https://openalex.org/W119184795', 'https://openalex.org/W1252577981', 'https://openalex.org/W1526433935', 'https://openalex.org/W1555798239', 'https://openalex.org/W1614748892', 'https://openalex.org/W1669763518', 'https://openalex.org/W1682474579', 'https://openalex.org/W1796787464', 'https://openalex.org/W1804680040', 'https://openalex.org/W1828224642', 'https://openalex.org/W1833330468', 'https://openalex.org/W1837236202', 'https://openalex.org/W1866647776', 'https://openalex.org/W1888375872', 'https://openalex.org/W1895775305', 'https://openalex.org/W1911376378', 'https://openalex.org/W1918322381', 'https://openalex.org/W1960713055', 'https://openalex.org/W1964226280', 'https://openalex.org/W1972065523', 'https://openalex.org/W1972380212', 'https://openalex.org/W1972536070', 'https://openalex.org/W1981123302', 'https://openalex.org/W1982230933', 'https://openalex.org/W1988680855', 'https://openalex.org/W1992437129', 'https://openalex.org/W1992786087', 'https://openalex.org/W1998260358', 'https://openalex.org/W2010256259', 'https://openalex.org/W2014325593', 'https://openalex.org/W2016254453', 'https://openalex.org/W2019806179', 'https://openalex.org/W2022361916', 'https://openalex.org/W2026172548', 'https://openalex.org/W2029542561', 'https://openalex.org/W2034113803', 'https://openalex.org/W2035928588', 'https://openalex.org/W2037501592', 'https://openalex.org/W2037563014', 'https://openalex.org/W2040742346', 'https://openalex.org/W2042308398', 'https://openalex.org/W2042352187', 'https://openalex.org/W2047523295', 'https://openalex.org/W2068524399', 'https://openalex.org/W2070825008', 'https://openalex.org/W2076315300', 'https://openalex.org/W2078241672', 'https://openalex.org/W2122077495', 'https://openalex.org/W2133003338', 'https://openalex.org/W2147529602', 'https://openalex.org/W2156246685', 'https://openalex.org/W2165837635', 'https://openalex.org/W2166003952', 'https://openalex.org/W2176579253', 'https://openalex.org/W2220500259', 'https://openalex.org/W2232368099', 'https://openalex.org/W2265187605', 'https://openalex.org/W2318605753', 'https://openalex.org/W2409090678', 'https://openalex.org/W2411135474', 'https://openalex.org/W2412362958', 'https://openalex.org/W2418284759', 'https://openalex.org/W4238407987', 'https://openalex.org/W4239462698', 'https://openalex.org/W4285719527', 'https://openalex.org/W82259717'], 'related_works': ['https://openalex.org/W95894433', 'https://openalex.org/W4323066430', 'https://openalex.org/W4316041250', 'https://openalex.org/W2730846812', 'https://openalex.org/W2569855433', 'https://openalex.org/W2420051576', 'https://openalex.org/W2396926985', 'https://openalex.org/W2157841994', 'https://openalex.org/W2053291556', 'https://openalex.org/W1992099483'], 'abstract_inverted_index': {'Doxorubicin,': [0], 'either': [1], 'as': [2], 'a': [3, 35, 71, 84], 'single': [4], 'agent': [5], 'or': [6], 'in': [7, 21, 97], 'combination': [8], 'regimens,': [9], 'is': [10, 32], 'considered': [11], 'to': [12, 43], 'be': [13], 'one': [14], 'of': [15, 24, 58, 65, 82, 101], 'the': [16, 22, 55, 94, 98], 'most': [17], 'active': [18], 'chemotherapeutic': [19], 'agents': [20], 'treatment': [23], 'metastatic': [25], 'breast': [26, 102], 'cancer.': [27, 103], 'However,': [28], 'its': [29], 'clinical': [30], 'utility': [31], 'limited': [33], 'by': [34], 'cumulative,': [36], 'dose-dependent': [37], 'cardiac': [38], 'myopathy': [39], 'that': [40], 'can': [41], 'lead': [42], 'potentially': [44], 'fatal': [45], 'congestive': [46], 'heart': [47], 'failure.': [48], 'Considerable': [49], 'research': [50], 'has': [51, 70], 'gone': [52], 'into': [53], 'improving': [54], 'therapeutic': [56, 74, 95], 'index': [57, 75], 'doxorubicin-based': [59], 'regimens.': [60], 'A': [61], 'new': [62], 'liposomal': [63], 'formulation': [64], 'doxorubicin': [66], '(Myocet,': [67], 'Elan': [68], 'Pharmaceuticals)': [69], 'significantly': [72], 'improved': [73], 'compared': [76], 'with': [77], 'conventional': [78], 'doxorubicin.': [79], 'The': [80], 'development': [81], 'Myocet,': [83], 'less': [85], 'cardiotoxic,': [86], 'better': [87], 'tolerated': [88], 'and': [89], 'equally': [90], 'efficacious': [91], 'doxorubicin,': [92], 'extends': [93], 'options': [96], 'overall': [99], 'management': [100]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2096607288', 'counts_by_year': [{'year': 2024, 'cited_by_count': 17}, {'year': 2023, 'cited_by_count': 18}, {'year': 2022, 'cited_by_count': 12}, {'year': 2021, 'cited_by_count': 19}, {'year': 2020, 'cited_by_count': 12}, {'year': 2019, 'cited_by_count': 7}, {'year': 2018, 'cited_by_count': 12}, {'year': 2017, 'cited_by_count': 4}, {'year': 2016, 'cited_by_count': 6}, {'year': 2015, 'cited_by_count': 2}, {'year': 2014, 'cited_by_count': 8}, {'year': 2013, 'cited_by_count': 3}, {'year': 2012, 'cited_by_count': 3}], 'updated_date': '2024-09-16T15:38:43.499147', 'created_date': '2016-06-24'}