Publication Information

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401, 421, 452, 496, 552, 680, 686, 771, 776, 838, 955, 1119, 1122, 1147, 1181, 1269, 1448, 1620, 1776, 1811, 1885, 1915, 1928, 1937, 1957, 1986, 1996, 2033, 2208, 2226, 2297, 2370, 2518, 2565, 2719, 2842, 2860, 3069, 3079, 3112, 3144, 3148, 3376, 3393, 3409, 3454, 3470, 3474, 3483, 3581, 3583, 3588, 3602, 3636, 3640, 3648, 3654, 3736, 3744, 3791, 3816, 3882, 3942, 4033, 4043, 4094, 4127, 4261, 4304, 4307, 4330, 4378, 4446, 4455], 'role': [3, 190, 450, 516, 912], 'of': [4, 15, 35, 82, 93, 101, 109, 115, 120, 131, 137, 146, 157, 178, 191, 202, 222, 269, 280, 288, 296, 302, 307, 318, 324, 333, 344, 365, 400, 454, 473, 488, 554, 564, 657, 669, 683, 715, 775, 833, 841, 904, 918, 957, 980, 1121, 1223, 1256, 1268, 1314, 1356, 1439, 1498, 1503, 1505, 1540, 1592, 1645, 1649, 1687, 1697, 1710, 1722, 1778, 1792, 1804, 1817, 1893, 1918, 1939, 1951, 1964, 1989, 1995, 1998, 2006, 2099, 2111, 2141, 2150, 2163, 2225, 2263, 2275, 2302, 2393, 2438, 2567, 2612, 2624, 2640, 2764, 2841, 2905, 2940, 2943, 2963, 2986, 2998, 3114, 3147, 3172, 3184, 3234, 3253, 3271, 3275, 3317, 3329, 3344, 3357, 3365, 3380, 3383, 3389, 3397, 3400, 3447, 3476, 3537, 3546, 3578, 3585, 3591, 3650, 3677, 3688, 3714, 3722, 3746, 3801, 3818, 3850, 3858, 3884, 3889, 3927, 3944, 4014, 4062, 4069, 4082, 4099, 4189, 4205, 4269, 4273, 4341, 4364, 4382, 4400, 4414], 'leptin': [5, 192, 494, 497, 534, 580, 618, 684, 744, 842, 874, 1825, 2007, 2034, 2064], 'in': [6, 88, 107, 116, 122, 142, 154, 171, 193, 275, 294, 303, 309, 329, 341, 358, 420, 451, 491, 501, 504, 517, 542, 649, 671, 678, 717, 734, 779, 837, 879, 913, 1011, 1029, 1078, 1084, 1098, 1177, 1202, 1258, 1259, 1262, 1273, 1282, 1309, 1413, 1441, 1548, 1573, 1596, 1628, 1654, 1682, 1786, 1796, 1807, 1810, 1943, 1966, 2013, 2024, 2222, 2386, 2398, 2406, 2411, 2558, 2564, 2574, 2644, 2653, 2734, 2844, 2853, 2899, 2949, 3076, 3102, 3161, 3191, 3197, 3220, 3244, 3246, 3287, 3310, 3348, 3392, 3436, 3482, 3497, 3513, 3519, 3566, 3580, 3587, 3606, 3616, 3631, 3639, 3666, 3738, 3761, 3766, 3783, 3793, 3821, 3861, 3879, 3905, 3909, 3916, 3950, 3967, 3974, 3984, 4004, 4025, 4042, 4109, 4152, 4166, 4171, 4222, 4229, 4233, 4289, 4295, 4309, 4329], 'PKCβ': [7, 16, 26, 74, 121, 165, 194, 203, 213, 261, 308, 352, 1243, 1264, 1564, 1678, 1779, 1793, 1886, 1919, 1940, 1965, 1999, 2036, 2067, 2084, 3115, 3899, 3945, 4023], 'action': [8, 195, 541, 550, 712], 'and': [9, 27, 32, 37, 61, 84, 99, 103, 139, 184, 196, 214, 219, 224, 248, 271, 286, 290, 326, 371, 405, 466, 476, 506, 520, 528, 579, 604, 623, 646, 743, 763, 835, 916, 954, 989, 1007, 1032, 1048, 1055, 1057, 1061, 1087, 1101, 1105, 1112, 1126, 1138, 1180, 1204, 1228, 1261, 1276, 1404, 1410, 1451, 1691, 1720, 1725, 1754, 1783, 1788, 1801, 1826, 1849, 1909, 1924, 1977, 1979, 2008, 2035, 2066, 2083, 2109, 2114, 2144, 2171, 2178, 2200, 2235, 2273, 2278, 2327, 2339, 2354, 2360, 2373, 2382, 2403, 2409, 2418, 2422, 2426, 2442, 2457, 2467, 2481, 2503, 2509, 2514, 2529, 2569, 2589, 2591, 2595, 2622, 2627, 2651, 2718, 2747, 2769, 2803, 2807, 2815, 2891, 2914, 2960, 2996, 3001, 3030, 3078, 3132, 3139, 3174, 3194, 3207, 3225, 3258, 3290, 3295, 3307, 3313, 3320, 3325, 3333, 3338, 3363, 3378, 3395, 3493, 3505, 3622, 3653, 3691, 3703, 3826, 3918, 3958, 4064, 4086, 4092, 4102, 4122, 4143, 4157, 4168, 4208, 4249, 4332, 4343, 4384, 4397, 4403, 4411], 'to': [10, 69, 197, 256, 512, 538, 585, 769, 927, 1072, 1089, 1103, 1111, 1156, 1184, 1187, 1253, 1278, 1551, 1568, 1616, 1619, 1624, 1925, 2058, 2072, 2169, 2197, 2433, 2648, 2761, 2834, 2851, 2875, 2886, 3126, 3248, 3442, 3517, 3574, 3612, 3626, 3635, 3681, 3749, 3779, 3797, 3881, 3930, 3981, 4416, 4443], 'determine': [11, 198, 3663], 'protective': [13, 200, 1916], 'potential': [14, 201, 1917], 'deficiency': [17, 75, 166, 204, 262, 353, 1749, 1780, 1791, 1844, 1920, 2000, 3025, 3116, 3900, 3946, 4024], 'on': [18, 205, 463, 551, 685, 843, 987, 1231, 1507, 1781, 1921, 1948, 1956, 2001, 2049, 2131, 2154, 2213, 2291, 2313, 2420, 2473, 2774, 3117, 3947, 4120, 4419], 'profound': [19, 206, 1922], 'obesity,': [20, 170, 207, 357, 1904], 'double': [21, 208, 2028, 2074], 'knockout': [22, 209, 2029, 2075], '(DBKO)': [23, 210, 1969], 'mice': [24, 43, 50, 66, 127, 148, 211, 230, 237, 253, 314, 335, 1690, 1716, 1819, 1876, 1901, 1947, 1968, 2044, 2048, 2069, 2105, 2135, 2202, 2269, 2292, 2314, 2321, 2618, 2749, 2992, 3125, 3146, 3152, 3193, 3219, 3227, 3277, 3289, 3382, 3399, 3439, 3485, 3502, 3515, 3523, 3548, 3568, 3593, 3679, 3709, 3730, 3748, 3764, 3769, 3803, 3807, 3891, 3923, 3970, 3976, 3986, 3999, 4010, 4027, 4037, 4066, 4111, 4134, 4142, 4159, 4177, 4198, 4225, 4238, 4246, 4275, 4279, 4298, 4318, 4334, 4369, 4405, 4418], 'lacking': [25, 212, 2032], 'ob': [28, 215], 'genes': [29, 216, 492, 556, 1805, 2037, 3054], 'were': [30, 40, 67, 105, 217, 227, 254, 292, 2070, 2085, 2129, 2136, 2172, 2181, 2203, 2229, 2311, 2322, 2334, 2343, 2375, 2380, 2416, 2446, 2459, 2471, 2479, 2498, 2506, 2533, 2572, 2642, 2673, 2711, 2732, 2742, 2759, 2823, 2832, 2849, 2864, 2884, 2923, 2946, 3055, 3074, 3082, 3135, 3164, 3263, 3283, 3609, 3964, 4075, 4089, 4114, 4210, 4434], 'created,': [31, 218], 'key': [33, 220, 449, 911], 'parameters': [34, 221], 'metabolism': [36, 223, 519, 3949, 4021, 4052], 'body': [38, 55, 63, 225, 242, 250, 455, 2488, 2494, 3155, 3162, 3213, 3462, 3699, 3794, 3851, 3887, 4045, 4112, 4153, 4263, 4398], 'composition': [39, 226], 'studied.': [41, 228], 'DBKO': [42, 65, 110, 147, 229, 252, 297, 334, 2201, 2748, 3128, 3140, 3151, 3245, 3276, 3321, 3339, 3438, 3484, 3498, 3514, 3547, 3567, 3592, 3678, 3708, 3747, 3763, 3784, 3802, 3890, 3969, 3985, 3998, 4036, 4065, 4133, 4158, 4172, 4206, 4234, 4245, 4274, 4297, 4305, 4333, 4385, 4404], 'had': [44, 231, 2166, 4239], 'similar': [45, 232, 3264, 3712, 3929, 4339], 'caloric': [46, 233], 'intake': [47, 234, 460, 1696, 1830, 2180, 3668, 3690, 3724, 3740, 4088, 4272, 4353, 4363], 'as': [48, 235, 524, 529, 590, 1041, 1141, 1165, 1889, 2087, 2600, 2878, 2958, 3057, 3065, 3088, 3167, 3169, 3215, 3620, 3716, 3854, 4345, 4428], 'ob/ob': [49, 94, 126, 236, 281, 313, 1900, 1946, 1967, 1990, 2076, 2082, 2199, 2746, 3118, 3138, 3145, 3218, 3249, 3288, 3319, 3337, 3451, 3472, 3501, 3522, 3538, 3682, 3718, 3768, 3806, 3906, 3922, 3975, 4009, 4026, 4063, 4110, 4141, 4156, 4197, 4223, 4237, 4278, 4301, 4331, 4383, 4402], 'but': [51, 238, 1076, 1144, 1160, 3453], 'showed': [52, 239, 1676, 3491, 3540, 3549, 4000, 4038], 'significantly': [53, 240, 1693, 3204, 3550, 3596, 3759, 3965, 3989], 'reduced': [54, 241, 1823, 3188, 3205, 3241, 3444, 3565, 3576, 3597, 3603, 4270], 'fat': [56, 243, 1756, 1851, 2232, 2245, 2368, 2757, 3032, 3133, 3210, 3430, 3520, 3852, 4344], 'content,': [57, 244], 'improved': [58, 245, 3994, 4019, 4050], 'glucose': [59, 246, 518, 545, 1627, 1782, 2464, 2485, 2504, 3917, 3948, 3957, 3980, 4006, 4015, 4020, 4046, 4051], 'metabolism,': [60, 247, 1934], 'elevated': [62, 249, 1681, 3990], 'temperature.': [64, 251, 2671], 'resistant': [68, 255], 'high-fat': [70, 257, 1698], 'diet-induced': [71, 258, 1718, 2107, 2271, 2620, 2994], 'obesity.': [72, 259, 3939], 'Moreover,': [73, 260, 3979], 'increased': [76, 106, 129, 263, 293, 316, 1828, 1872, 1910, 3774, 3798, 3872, 4251], 'β-adrenergic': [77, 264, 2018], 'signaling': [78, 265, 581, 647, 1174, 1275, 1284, 1794, 1887, 2010, 2019], 'by': [79, 152, 173, 266, 339, 360, 457, 467, 486, 567, 617, 985, 1115, 1136, 1361, 1626, 1695, 2040, 2188, 2296, 2329, 2336, 2448, 2461, 2523, 2917, 3097, 3166, 3189, 3195, 3203, 3242, 3647, 4022, 4163, 4356, 4366, 4430], 'inducing': [80, 267], 'expression': [81, 100, 130, 141, 156, 268, 287, 317, 328, 343, 553, 920, 1080, 1803, 3062, 3067], 'β1-': [83, 270], 'β3-adrenergic': [85, 272], 'receptors': [86, 273, 465], '(β-ARs)': [87, 274], 'white': [89, 276, 1683, 2362, 3209, 3236, 3280], 'adipose': [90, 144, 179, 277, 331, 366, 478, 1684, 1797, 1812, 1894, 2363, 2394, 3237, 3260, 3607, 4100], 'tissue': [91, 145, 278, 332, 479, 1685, 1895, 2395, 2830, 2843, 3238, 3261, 3608, 4220], '(WAT)': [92, 279, 1686], 'mice.': [95, 111, 282, 298, 1991, 2026, 2079, 2477, 3071, 3129, 3141, 3199, 3250, 3322, 3340, 3437, 3785, 3907, 4235, 4302], 'Accordingly,': [96, 283], 'p38MAPK': [97, 284, 2699], 'activation': [98, 285, 472], 'PGC-1α': [102, 138, 289, 325], 'UCP-1': [104, 140, 291, 327, 2429, 2682], 'WAT': [108, 123, 295, 310, 3273], 'Consistent': [112, 299, 3556], 'with': [113, 300, 1070, 1447, 1822, 1879, 2045, 2159, 2366, 2424, 2484, 2656, 2678, 2811, 2817, 2837, 2893, 2925, 3123, 3143, 3179, 3217, 3300, 3450, 3469, 3531, 3557, 3728, 3805, 3815, 3914, 3938, 3972, 4008, 4032, 4277, 4300], 'results': [114, 301, 3085], 'vivo': [117, 304, 1260, 1574, 1787], 'studies,': [118, 305], 'inhibition': [119, 306], 'explants': [124, 311, 2831, 2848], 'from': [125, 312, 2231, 2244, 2369, 2745, 2870, 2912, 3335, 3361, 3375, 4181, 4196, 4440, 4454], 'also': [128, 315, 510, 1077, 1134, 1266, 1774, 3369, 3440, 3595, 3726, 3876, 3988, 4059], 'above': [132, 319, 4034], 'β-ARs.': [133, 159, 320, 346], 'In': [134, 321, 532, 2015, 3572, 4030, 4303], 'contrast,': [135, 322], 'induction': [136, 323, 1182, 1355], 'brown': [143, 330, 477, 2367, 3259, 3477, 3489], 'was': [149, 336, 1265, 1820, 2038, 2186, 2396, 2521, 2555, 2598, 2873, 2910, 3063, 3095, 3107, 3187, 3201, 3240, 3464, 3479, 3563, 3594, 3672, 3725, 3758, 3987, 4160, 4226, 4265, 4312, 4327, 4354], 'not': [150, 337, 1068, 1154, 1566, 1871, 3229, 3457, 3610, 3732, 4266], 'accompanied': [151, 338, 3202], 'changes': [153, 340, 3309], 'these': [158, 161, 345, 348, 1033, 1094, 4176, 4214], 'Collectively,': [160, 347], 'findings': [162, 349], 'suggest': [163, 350, 3897], 'that': [164, 351, 379, 613, 908, 1172, 1247, 1677, 1790, 1931, 1962, 3282, 3528, 3706, 3735, 3898, 4175, 4232, 4260], 'may': [167, 354, 2020, 3777, 3901], 'prevent': [168, 355], 'genetic': [169, 356, 3822], 'part,': [172, 359], 'remodeling': [174, 361], 'catabolic': [176, 363], 'function': [177, 364, 489, 984, 1714, 2103, 2267, 2616, 2990], 'tissues': [180, 367, 4101], 'through': [181, 368, 461, 713, 1973, 1980, 2011, 2825], 'β-ARs': [182, 369, 2012], 'dependent': [183, 370], 'independent': [185, 372, 2005], 'mechanisms.': [186, 373], 'Leptin': [374, 508, 709, 801], 'is': [375, 380, 483, 509, 615, 1175, 1244, 1679, 1692, 1870, 2004, 3368, 3431, 3645, 3659, 4257], 'an': [376, 525, 530, 2775, 2838, 4145], 'adipocyte-derived': [377], 'hormone': [378], 'required': [381], 'for': [382, 1124, 1129, 1149, 2022, 2081, 2207, 2316, 2324, 2351, 2539, 2666, 2767, 2772, 2856, 2880, 2902, 3052, 3433, 3674, 3698, 3743, 4373, 4436, 4451], 'normal': [383], 'energy': [384, 469, 1808, 1933, 1952, 1975, 1987, 2002, 3658, 3670, 3781, 3819, 3903, 4310, 4346], 'homeostasis': [385, 1785, 1809], '(1Zhang': [386], 'Y.': [387, 634, 1336, 1342, 1475, 1477, 1479, 1485], 'Proenca': [388], 'R.': [389, 696, 1641, 1704, 2093, 2257, 2606, 2980], 'Maffei': [390], 'M.': [391, 393, 562, 746, 866, 868, 944, 974, 1385, 1483, 1524, 1536, 1706, 1743, 1838, 2095, 2259, 2608, 2982, 3019], 'Barone': [392], 'Leopold': [394], 'L.': [395, 860, 1588], 'Friedman': [396], 'J.M.': [397, 418], 'Positional': [398], 'cloning': [399], 'mouse': [402, 2030, 2541, 2554], 'obese': [403, 1945, 3827], 'gene': [404, 919, 1941, 2906], 'its': [406, 1127, 1229], 'human': [407, 780, 3931], 'homologue.Nature.': [408], '1994;': [409], '372:': [410], '425-432Crossref': [411], 'PubMed': [412, 427, 441, 572, 662, 726, 790, 819, 853, 894, 936, 968, 996, 1018, 1213, 1238, 1324, 1373, 1421, 1465, 1515, 1559, 1605, 1669, 1731, 1768, 1863, 2120, 2284, 2633, 3007, 3044, 3832, 3866], 'Scopus': [413, 428, 442, 573, 663, 727, 791, 820, 854, 895, 937, 969, 997, 1019, 1214, 1239, 1325, 1374, 1422, 1466, 1516, 1560, 1606, 1670, 1732, 1769, 1864, 2121, 2285, 2634, 3008, 3045, 3833, 3867], '(11741)': [414], 'Google': [415, 430, 444, 575, 665, 729, 793, 822, 856, 897, 939, 971, 999, 1021, 1216, 1241, 1327, 1376, 1424, 1468, 1518, 1562, 1608, 1672, 1734, 1771, 1866, 2123, 2287, 2636, 3010, 3047, 3835, 3869], 'Scholar,': [416, 794, 823, 940, 972, 1217, 1328, 1377, 1425, 1469, 1735, 3011, 3836], '2Friedman': [417], 'Obesity': [419], 'new': [422], 'millennium.Nature.': [423], '2000;': [424, 438, 1418], '404:': [425], '632-634Crossref': [426], '(629)': [429], 'Scholar–3Ahima': [431], 'R.S.': [432], 'Flier': [433], 'J.S.': [434], 'Leptin.Annu.': [435], 'Rev.': [436, 961, 1013], 'Physiol.': [437, 930], '62:': [439], '413-437Crossref': [440], '(1487)': [443], 'Scholar).': [445, 576, 666, 730, 898, 1022, 1242, 1563, 1673, 1772, 1867, 2124, 2288, 2637, 3048, 3870], 'It': [446, 3200, 3624, 4256], 'plays': [447, 909], 'a': [448, 514, 810, 883, 901, 910, 1142, 1166, 1188, 1315, 1541, 1880, 1890, 2050, 2147, 2155, 2160, 2193, 2214, 2238, 2543, 2559, 2762, 2826, 2887, 2926, 2950, 3301, 3575, 3711, 3855, 3885, 3925, 3934, 4001, 4039, 4267, 4286, 4420, 4465], 'control': [453, 956, 3070, 3471], 'weight': [456, 2177, 3131, 3156, 3186, 3214, 3233, 3446, 3463, 3795, 4139, 4264], 'suppressing': [458], 'food': [459, 1829, 1911, 1971, 2179, 2568, 3651, 3667, 3689, 3715, 3723, 3739, 4087, 4271, 4321, 4350], 'actions': [462], 'hypothalamic': [464], 'increasing': [468, 620, 1974], 'expenditure': [470, 1976, 2003, 3671, 3820, 3904, 4311, 4396], 'via': [471, 619, 809, 882, 2500], 'sympathetic': [474], 'activity': [475, 774, 1409, 3512], '(BAT)': [480], 'thermogenesis.': [481], 'This': [482], 'best': [484], 'illustrated': [485], 'loss': [487], 'mutations': [490], 'encoding': [493], 'or': [495, 1158, 2237, 2341, 2428, 2490, 2664, 2688, 2698, 2739, 3100, 3695, 4016, 4360], 'receptor,': [498], 'which': [499, 1117, 2223, 3657], 'result': [500, 4268], 'severe': [502, 4070], 'obesity': [503, 1719, 1923, 2108, 2272, 2621, 2995, 3676, 4183], 'rodents': [505], 'humans.': [507], 'known': [511, 584], 'play': [513, 1279], 'dual': [515, 1280], 'insulin': [521, 526, 540, 549, 565, 578, 593, 672, 711, 718, 766, 777, 807, 1205, 1274, 1283, 1442, 1449, 1453, 1499, 1508, 1552, 1571, 1726, 1906, 1982, 2115, 2279, 2456, 2468, 2491, 2628, 3002, 3919, 3959, 3982, 3995], 'signaling,': [522], 'acting': [523], 'sensitizer': [527], 'antagonizer.': [531], 'vivo,': [533], 'has': [535, 675, 1248, 1613], 'been': [536, 676, 739, 1027, 1035, 1249, 1614], 'reported': [537, 1615], 'enhance': [539], 'inhibiting': [543], 'hepatic': [544, 1354, 1723, 2112, 2276, 2625, 2999, 3560, 4241], 'output': [546], 'while': [547], 'antagonizing': [548], 'metabolic': [555, 880, 3775, 3859, 4104], '(4Cohen': [557], 'B.': [558, 3846], 'Novick': [559], 'D.': [560, 976], 'Rubinstein': [561], 'Modulation': [563], 'activities': [566], 'leptin.Science.': [568], '1996;': [569], '274:': [570], '1185-1188Crossref': [571], '(651)': [574], 'The': [577, 1589, 1814, 2708, 2829, 2847, 3049, 3084, 3231, 3251, 3871, 3921, 4150, 4203, 4324], 'pathways': [582, 1285, 1930], 'are': [583, 1066, 1113, 1133, 1877, 3086, 3342, 3529, 3911, 4178, 4459, 4463], 'share': [586], 'downstream': [587], 'targets': [588], 'such': [589, 3619], 'Janus': [591], 'kinase-2,': [592], 'receptor': [594, 673, 719, 767, 778, 1443, 1450, 1500], 'substrates,': [595], 'phosphatidyl-inositol': [596], '3-kinase,': [597], 'protein': [598, 602, 605, 884, 906, 981, 1199, 1224, 1304, 1399, 1407, 1543, 1593, 1650, 1711, 2100, 2264, 2596, 2613, 2641, 2987], 'kinase': [599, 606, 758, 773, 805, 885, 924, 982, 1005, 1200, 1225, 1305, 1351, 1400, 1408, 1491, 1544, 1594, 1651, 1712, 1747, 1842, 2101, 2265, 2614, 2988, 3023], 'B,': [600], 'mitogen-activated': [601, 1406], 'kinase,': [603], 'C': [607, 759, 983, 1006, 1201, 1226, 1492, 1595, 1652, 1748, 1843, 3024], '(PKC).': [608], 'Recent': [609, 1168], 'data': [610, 3895, 4453], 'provide': [611], 'evidence': [612], 'PKC': [614, 742, 834, 953, 1064], 'activated': [616, 1114, 1135, 1176], 'calcium': [621, 1104, 1159], 'concentration': [622], 'stimulating': [624], 'inositol': [625], 'triphosphate': [626], '(IP-3)': [627], 'production': [628], '(5Takekoshi': [629], 'K.': [630, 632, 636, 694, 702, 950, 1291, 1332, 1344, 1473, 1489, 3844], 'Ishii': [631], 'Kawakami': [633], 'Isobe': [635], 'Nanmoku': [637], 'T.': [638, 640, 1330, 1340, 1471, 1635, 1639], 'Nakai': [639], 'Ca(2+)': [641], 'mobilization,': [642], 'tyrosine': [643, 772], 'hydroxylase': [644], 'activity,': [645], 'mechanisms': [648, 1197], 'cultured': [650], 'porcine': [651], 'adrenal': [652], 'medullary': [653], 'chromaffin': [654], 'cells:': [655], 'effects': [656, 1938, 3113], 'leptin.Endocrinology.': [658], '2001;': [659], '142:': [660], '290-298Crossref': [661], '(0)': [664], 'PKC-dependent': [667], 'phosphorylation': [668, 714, 986, 1497], 'Ser-318': [670], 'substrate-1': [674, 768, 1444, 1501], 'implicated': [677], 'mediating': [679], 'inhibitory': [681, 839], 'signal': [682, 914, 959, 1509], 'insulin-signaling': [687], 'cascade': [688], '(6Hennige': [689], 'A.M.': [690], 'Stefan': [691], 'N.': [692, 827, 1334, 1338], 'Kapp': [693], 'Lehmann': [695], 'Weigert': [697], 'C.': [698, 942, 1193, 1387, 1578], 'Beck': [699], 'A.': [700, 754, 829, 978, 1348, 1481], 'Moeschel': [701], 'Mushack': [703, 747], 'J.': [704, 722, 748, 825, 929, 1299, 1431, 1526, 1532, 1584], 'Schleicher': [705], 'E.': [706, 750, 1582], 'Haring': [707, 755], 'H.U.': [708, 756], 'down-regulates': [710], 'serine-318': [716], 'substrate': [720], '1.FASEB': [721], '2006;': [723], '20:': [724, 1419], '1206-1208Crossref': [725], '(83)': [728, 998], 'Several': [731], 'other': [732, 1008, 3254, 3617], 'interactions': [733, 1446], 'different': [735], 'physiological': [736], 'systems': [737], 'have': [738, 1026, 1034, 1145, 1170, 3153, 3524], 'described': [740, 2089, 2601, 3058], 'between': [741, 3137, 3265, 3961, 4155, 4213], '(7Kellerer': [745], 'Seffer': [749], 'Mischak': [751], 'H.': [752, 1487], 'Ullrich': [753], 'Protein': [757, 923, 1004, 1490, 1746, 1841, 3022], 'isoforms': [760, 1065, 1095, 1191, 1227, 1271], 'alpha,': [761], 'delta': [762], 'theta': [764], 'require': [765, 1139, 1163], 'inhibit': [770], 'kidney': [781], 'embryonic': [782], 'cells': [783, 1631], '(HEK': [784], '293': [785], 'cells).Diabetologia.': [786], '1998;': [787], '41:': [788], '833-838Crossref': [789], '(100)': [792], '8Lee': [795], 'J.W.': [796], 'Swick': [797], 'A.G.': [798], 'Romsos': [799], 'D.R.': [800, 1301], 'constrains': [802], 'phospholipase': [803], 'C-protein': [804], 'C-induced': [806], 'secretion': [808, 1572], 'phosphatidylinositol': [811], '3-kinase-dependent': [812], 'pathway.Exp.': [813], 'Biol.': [814, 890, 964, 1209, 1417, 1455, 1659, 1758, 1853, 3034], 'Med.(Maywood).': [815], '2003;': [816], '228:': [817], '175-182Crossref': [818], '(16)': [821], '9Barrenetxe': [824], 'Sainz': [826], 'Barber': [828], 'Lostao': [830], 'M.P.': [831], 'Involvement': [832], 'PKA': [836], 'effect': [840, 1997, 3943], 'intestinal': [844], 'galactose': [845], 'absorption.Biochem.': [846], 'Biophys.': [847], 'Res.': [848, 1234, 1364, 1511], 'Commun.': [849], '2004;': [850, 1321, 1512], '317:': [851], '717-721Crossref': [852], '(23)': [855], 'Scholar–10Payne': [857], 'G.A.': [858, 1643], 'Borbouse': [859], 'Kumar': [861], 'S.': [862, 946, 1346, 1522, 1528], 'Neeb': [863], 'Z.': [864], 'Alloosh': [865], 'Sturek': [867], 'Tune': [869], 'J.D.': [870], 'Epicardial': [871], 'perivascular': [872], 'adipose-derived': [873], 'exacerbates': [875], 'coronary': [876], 'endothelial': [877], 'dysfunction': [878], 'syndrome': [881], 'C-beta': [886], 'pathway.Arterioscler.': [887], 'Thromb.': [888, 1207], 'Vasc.': [889, 1208], '2010;': [891, 933, 965, 1235, 1365, 3829, 3863], '30:': [892, 1513], '1711-1717Crossref': [893], '(147)': [896], 'PKCs': [899, 1044, 1051, 1059, 1109, 1132, 1152], 'comprise': [900], 'large': [902, 3504, 3541], 'family': [903], 'serine/threonine': [905], 'kinases': [907], 'transduction': [915], 'regulation': [917], '(11Newton': [921], 'A.C.': [922], 'C:': [925, 3386], 'poised': [926], 'signal.Am.': [928], 'Endocrinol.': [931, 1320], 'Metab.': [932, 1555], '298:': [934], 'E395-E402Crossref': [935], '(397)': [938], '12Rosse': [941], 'Linch': [943], 'Kermorgant': [945], 'Cameron': [947], 'A.J.': [948], 'Boeckeler': [949], 'Parker': [951], 'P.J.': [952], 'localized': [958], 'dynamics.Nat.': [960], 'Mol.': [962], 'Cell': [963], '11:': [966], '103-112Crossref': [967], '(344)': [970], '13Freeley': [973], 'Kelleher': [975], 'Long': [977], 'Regulation': [979], 'conserved': [988], 'non-conserved': [990], 'sites.Cell.': [991], 'Signal.': [992], '2011;': [993], '23:': [994], '753-762Crossref': [995], 'Scholar–14Griner': [1000], 'E.M.': [1001], 'Kazanietz': [1002], 'M.G.': [1003], 'diacylglycerol': [1009], 'effectors': [1010], 'cancer.Nat.': [1012], 'Cancer.': [1014], '2007;': [1015], '7:': [1016], '281-294Crossref': [1017], '(778)': [1020], 'Twelve': [1023], 'distinct': [1024, 1039], 'members': [1025], 'discovered': [1028], 'mammalian': [1030], 'cells,': [1031, 3298], 'subdivided': [1036], 'into': [1037], 'three': [1038, 3381], 'subfamilies': [1040], 'follows:': [1042], 'conventional': [1043], '(α,': [1045], 'βI,': [1046], 'βII,': [1047], 'γ),': [1049], 'novel': [1050, 1891], '(δ,': [1052], '∊,': [1053], 'ν,': [1054], 'θ),': [1056], 'atypical': [1058], '(∊': [1060], 'ι/λ).': [1062], 'These': [1063, 1882, 2063, 3894], 'unique': [1067], 'only': [1069], 'respect': [1071], 'their': [1073, 1079, 3686], 'primary': [1074, 1629, 2679], 'structures': [1075], 'patterns,': [1081], 'subcellular': [1082], 'localization,': [1083], 'vitro': [1085], 'activation,': [1086], 'responsiveness': [1088, 1102], 'extracellular': [1090], 'signals.': [1091], 'Most': [1092], 'importantly,': [1093], 'show': [1096, 3443, 3705], 'differences': [1097, 3160, 3792], 'cofactor': [1099, 1143], 'dependence': [1100], 'phospholipid': [1106], 'metabolites.': [1107], 'Conventional': [1108], 'bind': [1110], 'sn-1,2-diacylglycerol,': [1116], 'increases': [1118, 1750, 1845, 3026], 'specificity': [1120], 'enzyme': [1123], 'phosphatidylserine': [1125, 1140, 1164], 'affinity': [1128], 'calcium.': [1130, 1150], 'Novel': [1131], 'DAG': [1137, 1157], 'lost': [1146], 'requirement': [1148], 'Atypical': [1151], 'do': [1153], 'respond': [1155], 'apparently': [1161], 'still': [1162], 'cofactor.': [1167], 'studies': [1169, 1883], 'shown': [1171, 3087], 'DAG-PKC': [1173], 'diabetic': [1178, 1232], 'conditions,': [1179], 'appears': [1183, 1277], 'be': [1185, 3627, 3877], 'restricted': [1186], 'few': [1189], '"diabetic-related"': [1190], '(15Rask-Madsen': [1192], 'King': [1194, 1220], 'G.L.': [1195, 1221], 'Proatherosclerotic': [1196], 'involving': [1198], 'diabetes': [1203, 3928], 'resistance.Arterioscler.': [1206], '2005;': [1210], '25:': [1211], '487-496Crossref': [1212], '(153)': [1215], '16Geraldes': [1218], 'P.': [1219, 1379, 1633], 'Activation': [1222], 'impact': [1230, 1777], 'complications.Circ.': [1233], '106:': [1236], '1319-1331Crossref': [1237], '(608)': [1240], 'one': [1245, 1267], 'isoform': [1246], 'most': [1250], 'directly': [1251], 'linked': [1252], 'important': [1254], 'aspects': [1255], 'hyperglycemia': [1257], 'vitro.': [1263], 'earliest': [1270], 'recognized': [1272], 'roles': [1281, 1591], '(17Patel': [1286], 'N.A.': [1287], 'Apostolatos': [1288], 'H.S.': [1289], 'Mebert': [1290], 'Chalfant': [1292], 'C.E.': [1293], 'Watson': [1294], 'J.E.': [1295], 'Pillay': [1296], 'T.S.': [1297], 'Sparks': [1298], 'Cooper': [1300], 'Insulin': [1302], 'regulates': [1303], 'CbetaII': [1306], 'alternative': [1307, 3613], 'splicing': [1308], 'multiple': [1310], 'target': [1311], 'tissues:': [1312], 'development': [1313, 1721, 2110, 2274, 2623, 2997], 'hormonally': [1316], 'responsive': [1317], 'heterologous': [1318], 'minigene.Mol.': [1319], '18:': [1322], '899-911Crossref': [1323], '(31)': [1326], '18Yamamoto': [1329], 'Watanabe': [1331], 'Inoue': [1333], 'Nakagawa': [1335], 'Ishigaki': [1337], 'Matsuzaka': [1339], 'Takeuchi': [1341], 'Kobayashi': [1343], 'Yatoh': [1345], 'Takahashi': [1347], 'et': [1349, 4054], 'al.Protein': [1350], 'Cbeta': [1352, 1401, 1545, 1713, 2102, 2266, 2615, 2989], 'mediates': [1353], 'sterol-regulatory': [1357], 'element': [1358], 'binding': [1359], 'protein-1c': [1360], 'insulin.J.': [1362], 'Lipid': [1363], '51:': [1366], '1859-1870Abstract': [1367], 'Full': [1368, 1370, 1460, 1462, 1664, 1666, 1763, 1765, 1858, 1860, 3039, 3041], 'Text': [1369, 1371, 1461, 1463, 1665, 1667, 1764, 1766, 1859, 1861, 3040, 3042], 'PDF': [1372, 1464, 1668, 1767, 1862, 3043], '(25)': [1375], '19Formisano': [1378], 'Oriente': [1380], 'F.': [1381, 1383, 1391, 1397, 1530], 'Fiory': [1382], 'Caruso': [1384], 'Miele': [1386], 'Maitan': [1388], 'M.A.': [1389, 1520], 'Andreozzi': [1390], 'Vigliotta': [1392], 'G.': [1393, 1395], 'Condorelli': [1394], 'Beguinot': [1396], 'Insulin-activated': [1398], 'bypasses': [1402], 'Ras': [1403], 'stimulates': [1405], 'cell': [1411], 'proliferation': [1412], 'muscle': [1414, 3314, 3364, 3379, 3396, 3590], 'cells.Mol.': [1415], 'Cell.': [1416], '6323-6333Crossref': [1420], '(67)': [1423], '20Aguirre': [1426], 'V.': [1427], 'Werner': [1428], 'E.D.': [1429], 'Giraud': [1430], 'Lee': [1432], 'Y.H.': [1433], 'Shoelson': [1434], 'S.E.': [1435], 'White': [1436], 'M.F.': [1437], 'Phosphorylation': [1438], 'Ser307': [1440], 'blocks': [1445], 'inhibits': [1452], 'action.J.': [1454], 'Chem.': [1456, 1660, 1759, 1854, 3035], '2002;': [1457, 1661], '277:': [1458, 1662], '1531-1537Abstract': [1459], '(767)': [1467], '21Ishizuka': [1470], 'Kajita': [1472], 'Natsume': [1474], 'Kawai': [1476], 'Kanoh': [1478], 'Miura': [1480], 'Ishizawa': [1482], 'Uno': [1484], 'Morita': [1486], 'Yasuda': [1488], '(PKC)': [1493], 'beta': [1494], 'modulates': [1495], 'serine': [1496], '(IRS-1)–effect': [1502], 'overexpression': [1504], 'PKCbeta': [1506], 'transduction.Endocr.': [1510], '287-299Crossref': [1514], '(20)': [1517], 'Scholar–22Osterhoff': [1519], 'Heuer': [1521], 'Pfeiffer': [1523, 1537], 'Tasic': [1525], 'Kaiser': [1527], 'Isken': [1529], 'Spranger': [1531], 'Weickert': [1533], 'M.O.': [1534], 'Mohlig': [1535], 'A.F.': [1538], 'Identification': [1539, 3849], 'functional': [1542], 'promoter': [1546], 'polymorphism': [1547], 'humans': [1549], 'related': [1550], 'resistance.Mol.': [1553], 'Genet.': [1554], '2008;': [1556, 1602, 1760, 1855, 3036], '93:': [1557], '210-215Crossref': [1558], '(14)': [1561], 'does': [1565], 'appear': [1567], 'regulate': [1569], 'glucose-induced': [1570, 1646], '(23Biden': [1575], 'T.J.': [1576], 'Schmitz-Peiffer': [1577], 'Burchfield': [1579], 'J.G.': [1580], 'Gurisik': [1581], 'Cantley': [1583], 'Mitchell': [1585], 'C.J.': [1586], 'Carpenter': [1587], 'diverse': [1590, 1949], 'pancreatic': [1597, 1656], 'β-cell': [1598], 'function.Biochem.': [1599], 'Soc.': [1600], 'Trans.': [1601], '36:': [1603], '916-919Crossref': [1604], '(22)': [1607], 'Scholar),': [1609], 'even': [1610, 3176, 4116], 'though': [1611], 'it': [1612], 'undergo': [1617], 'translocation': [1618], 'plasma': [1621, 2340, 3956, 4005], 'membrane': [1622, 1647], 'subsequent': [1623], 'stimulation': [1625], 'islet': [1630], '(24Pinton': [1632], 'Tsuboi': [1634], 'Ainscow': [1636], 'E.K.': [1637], 'Pozzan': [1638], 'Rizzuto': [1640], 'Rutter': [1642], 'Dynamics': [1644], 'recruitment': [1648], 'βII': [1653], 'living': [1655], 'islets': [1657], 'β-cells.J.': [1658], '37702-37710Abstract': [1663], '(76)': [1671], 'We': [1674, 1773, 1960, 3786, 4058], 'recently': [1675], 'markedly': [1680], 'leptin-deficient': [1688], '(ob/ob)': [1689], 'induced': [1694], 'diet': [1699, 2240, 4422], '(HFD)': [1700], '(25Huang': [1701, 2090, 2254, 2603, 2977], 'W.': [1702, 1739, 1834, 2091, 2255, 2604, 2978, 3015], 'Bansode': [1703, 2092, 2256, 2605, 2979], 'Mehta': [1705, 1707, 1742, 1744, 1837, 1839, 2094, 2096, 2258, 2260, 2607, 2609, 2981, 2983, 3018, 3020], 'K.D.': [1708, 1745, 1840, 2097, 2261, 2610, 2984, 3021], 'Loss': [1709, 2098, 2262, 2611, 2985], 'protects': [1715, 2104, 2268, 2617, 2991], 'against': [1717, 2106, 2270, 2619, 2681, 2993], 'steatosis': [1724, 2113, 2277, 2626, 3000], 'resistance.Hepatology.': [1727, 2116, 2280, 2629, 3003], '2009;': [1728, 2117, 2281, 2630, 3004], '49:': [1729, 2118, 2282, 2631, 3005], '1525-1536Crossref': [1730, 2119, 2283, 2632, 3006], '(53)': [1733, 2122, 2286, 2635, 3009], '26Bansode': [1736, 3012], 'R.R.': [1737, 1832, 3013], 'Huang': [1738, 1833, 3014], 'Roy': [1740, 1835, 3016], 'S.K.': [1741, 1836, 3017], 'fatty': [1751, 1846, 2444, 3027], 'acid': [1752, 1847, 3028], 'oxidation': [1753, 1848, 3029], 'reduces': [1755, 1850, 3031], 'storage.J.': [1757, 1852, 3033], '283:': [1761, 1856, 3037], '231-236Abstract': [1762, 1857, 3038], '(46)': [1770, 1865, 3046], 'assessed': [1775, 2187], 'lipid': [1784, 3359, 3495, 3507, 3532, 3614], 'found': [1789], 'resulted': [1795], 'atrophy,': [1798], 'hypoleptinemia,': [1799], 'hyperphagia,': [1800, 1905], 'altered': [1802], 'involved': [1806], 'tissue.': [1813], 'lean': [1815, 3825], 'phenotype': [1816, 4147], 'PKCβ−/−': [1818, 1898, 2025, 2047, 2078, 3124], 'associated': [1821, 3913, 3937], 'serum': [1824], 'compensatory': [1827], '(26Bansode': [1831], 'Furthermore,': [1868, 3488], 'adiposity': [1869, 3910], 'when': [1873, 3461, 4317], 'PKCβ-deficient': [1874], '(PKCβ−/−)': [1875], 'challenged': [1878], 'HFD.': [1881, 4407], 'identified': [1884], 'pathway': [1888], 'modulator': [1892], 'homeostasis.': [1896, 3920], 'Unlike': [1897], 'mice,': [1899, 3452, 3473, 3499, 3683, 3952, 4173, 4306], 'exhibit': [1902, 4250], 'marked': [1903, 4164], 'resistance,': [1907], 'hypothermia,': [1908], 'efficiency.': [1912], 'better': [1926], 'understand': [1927], 'regulatory': [1929], 'govern': [1932], 'we': [1935, 3120, 3684, 3953, 4096], 'examined': [1936, 4097], 'disruption': [1942], 'genetically': [1944], 'elements': [1950], 'balance,': [1953], 'focusing': [1954], 'particularly': [1955], 'β-AR': [1958], 'signaling.': [1959], 'report': [1961], 'deletion': [1963], 'decreases': [1970], 'efficiency': [1972], 'thermogenesis': [1978, 3435], 'enhanced': [1981, 2017, 2720], 'sensitivity,': [1983], 'thus': [1984], 'improving': [1985], 'balance': [1988, 3782], 'A': [1992, 2027, 2463, 3812, 4106], 'significant': [1993, 4002, 4040, 4107, 4287], 'component': [1994], 'involves': [2009], 'WAT.': [2014], 'fact,': [2016], 'account': [2021, 3742], 'hypoleptinemia': [2023], 'simultaneously': [2031, 2535], 'generated': [2039], 'intercrossing': [2041], 'male': [2042, 2132, 3198, 3221, 3318, 3336, 3398, 3707, 3717, 3762, 3767, 4224, 4368, 4401], 'ob/ob+/−': [2043], 'female': [2046, 3192, 3226, 3729], 'C57BL/6J': [2051], 'background': [2052], '(Jackson': [2053], 'Laboratories,': [2054, 2250], 'Bar': [2055], 'Harbor,': [2056], 'ME)': [2057], 'generate': [2059, 2073, 3127], 'ob+/−': [2060], 'x': [2061, 2077], 'PKCβ−/−.': [2062], 'heterozygous': [2065], 'homozygous': [2068], 'used': [2071], 'Genotyping': [2080], 'performed': [2086, 2130, 2312, 2472, 2733, 2865, 3096], 'previously': [2088], 'Unless': [2125, 2307], 'indicated,': [2126, 2308], 'all': [2127, 2309], 'experiments': [2128, 2310], 'animals.': [2133], 'Male': [2134], 'weaned': [2137], 'at': [2138, 2146, 2348, 2356, 2562, 2669, 2676, 2686, 2696, 2706, 3656, 3756, 4079, 4093, 4315], '21': [2139], 'days': [2140], 'age,': [2142, 3150, 3185], 'genotyped,': [2143], 'maintained': [2145], 'room': [2148, 2670], 'temperature': [2149, 2185, 2191, 3888, 4399], '22': [2151], '±': [2152, 3090, 3411, 4380], '2°C': [2153], '12:12': [2156], 'light-dark': [2157], 'cycle': [2158], 'relative': [2161, 3680], 'humidity': [2162], '50%.': [2164], 'Animals': [2165], 'free': [2167], 'access': [2168], 'water': [2170], 'fed': [2173, 2204, 4076, 4135, 4199, 4406], 'ad': [2174, 2205], 'libitum.': [2175], 'Body': [2176, 2184, 3130, 4084], 'registered': [2182], 'weekly.': [2183], 'measuring': [2189, 4357], 'rectal': [2190, 2194], 'using': [2192, 2451, 2542, 2713, 2919, 2955], 'thermometer.': [2195], 'Seven-': [2196], 'eight-week-old': [2198], 'libitum': [2206], 'indicated': [2209, 2879, 3053], 'period': [2210], 'continuously': [2211], 'either': [2212], 'HFD': [2215, 4077, 4136, 4200, 4365], '(D12492;': [2216], 'Research': [2217], 'Diets,': [2218], 'New': [2219], 'Brunswick,': [2220], 'NJ)': [2221], '60%': [2224], 'total': [2227, 2440, 2944, 3358], 'calories': [2228], 'derived': [2230], '(soybean': [2233], 'oil': [2234], 'lard)': [2236], 'standard': [2239, 2434], 'containing': [2241, 2576, 2659, 2779, 2819], '17%': [2242], 'kcal': [2243], '(7912': [2246], 'rodent': [2247], 'chow;': [2248], 'Harlan': [2249], 'Inc.,': [2251, 2693], 'Indianapolis,': [2252], 'IN)': [2253], 'All': [2289, 2730, 2862, 3072, 3092, 4461], 'procedures': [2290, 2863], 'followed': [2293], 'guidelines': [2294], 'established': [2295], 'Ohio': [2298], 'State': [2299], 'University': [2300], 'College': [2301], 'Medicine': [2303], 'Animal': [2304], 'Care': [2305], 'Committee.': [2306], 'starved': [2315], 'approximately': [2317], '16': [2318, 2881, 3404], 'h.': [2319, 2882], 'Eighteen-week-old': [2320], 'fasted': [2323, 2474, 3968], '6': [2325, 3347, 3415], 'h': [2326, 2538, 2668, 2858, 4438, 4458], 'euthanized': [2328], 'CO2': [2330, 2527], 'inhalation.': [2331], 'Blood': [2332, 2496], 'samples': [2333, 2379, 2497, 2916, 3073], 'obtained': [2335], 'submandibular': [2337], 'bleeding,': [2338], 'sera': [2342], 'collected': [2344, 2499], 'after': [2345, 2517, 4011, 4117], 'centrifugation': [2346], '(4°C)': [2347], '12,000': [2349], 'rpm': [2350], '15': [2352], 'min': [2353, 2516], 'stored': [2355], '−20°C.': [2357], 'Epididymal,': [2358], 'inguinal,': [2359], 'retroperitoneal': [2361, 3208], 'tissues,': [2364, 3255, 3618], 'together': [2365], 'interscapular': [2371, 2740, 3331], 'depot,': [2372], 'livers': [2374, 3527, 4209], 'carefully': [2376], 'excised.': [2377], 'Tissue': [2378], 'weighed': [2381, 2480], 'then': [2383, 2404, 2808], 'immediately': [2384], 'frozen': [2385], 'liquid': [2387, 2900], 'nitrogen.': [2388], 'For': [2389, 2934], 'morphological': [2390], 'assessment,': [2391], 'parts': [2392], 'fixed': [2397], '4%': [2399], 'buffered': [2400], 'formaldehyde': [2401], 'overnight': [2402, 2675], 'dehydrated': [2405], 'graded': [2407], 'ethanols': [2408], 'embedded': [2410], 'paraffin.': [2412], 'Sections': [2413], '(10': [2414], 'μm)': [2415], 'cut': [2417], 'mounted': [2419], 'slides': [2421], 'stained': [2423, 3294], 'hematoxylin': [2425], 'eosin': [2427, 3326], 'antibody': [2430], '(1:500)-HRP': [2431], 'according': [2432], 'protocols.': [2435], 'Plasma': [2436], 'concentrations': [2437, 2505], 'triglycerides,': [2439], 'cholesterol,': [2441], 'serum-free': [2443], 'acids': [2445], 'measured': [2447, 2507, 2534, 2556, 2599, 4429], 'enzymatic': [2449], 'methods': [2450], 'commercially': [2452], 'available': [2453], 'kits.': [2454], 'Serum': [2455], 'adiponectin': [2458], 'determined': [2460, 2522, 4355], 'ELISA.': [2462], 'tolerance': [2465, 2469], 'test': [2466, 2470], '(16': [2475], 'h)': [2476], 'Mice': [2478, 4433], 'injected': [2482], 'intraperitoneally': [2483], '(1.5': [2486], 'mg/kg': [2487], 'weight)': [2489], '(0.8': [2492], 'U/kg': [2493], 'weight).': [2495], 'tail': [2501], 'bleeds,': [2502], 'before': [2508, 2859, 2896], '15,': [2510], '30,': [2511], '60,': [2512], '90,': [2513], '120': [2515], 'challenge.': [2519], 'Glucose': [2520], 'glucometer.': [2524], 'Oxygen': [2525], 'consumption,': [2526], 'production,': [2528], 'spontaneous': [2530], 'physical': [2531], 'movement': [2532], 'over': [2536, 3068], '24': [2537, 4437], 'each': [2540, 2845, 2876, 3349, 3384, 4374, 4426], 'computer-controlled,': [2544], 'open-circuit': [2545], 'Oxymax/': [2546], 'CLAMS': [2547], 'System': [2548], '(Columbus': [2549], 'Instruments,': [2550], 'Columbus,': [2551], 'OH).': [2552], 'Each': [2553, 3371, 3406], 'individually': [2557], 'resting': [2560], 'state': [2561], '22°C': [2563], 'presence': [2566], 'water.': [2570], 'Tissues': [2571], 'homogenized': [2573], 'buffer': [2575, 2782, 2814], '20': [2577, 2658, 2951], 'mM': [2578, 2581, 2584, 2784, 2789, 2792, 2795, 2798, 2801, 2805], 'Tris,': [2579], '50': [2580, 2961], 'NaCl,': [2582, 2790], '250': [2583], 'sucrose,': [2585], '1%': [2586], 'Triton': [2587], 'X-100,': [2588], 'phosphatase': [2590], 'protease': [2592], 'inhibitors': [2593], 'cocktail,': [2594], 'content': [2597, 3134, 3316, 3562, 4243], 'earlier': [2602], 'Equal': [2638], 'amounts': [2639, 2939, 3388], 'run': [2643, 3075], '12%': [2645], 'SDS-PAGE,': [2646], 'transferred': [2647, 2833, 2885], 'nitrocellulose': [2649], 'membranes,': [2650], 'blocked': [2652], 'Tris-buffered': [2654], 'saline': [2655], 'Tween': [2657], '5%': [2660], 'nonfat': [2661], 'dry': [2662], 'milk': [2663], 'BSA': [2665], '1': [2667, 2857, 4358], 'Blots': [2672], 'incubated': [2674], '4°C': [2677], 'antibodies': [2680, 2716], '(Abcam,': [2683], 'Cambridge,': [2684], 'MA)': [2685, 2695], '1:2,000;': [2687], 'P-p38MAPK': [2689], '(Cell': [2690], 'Signaling': [2691], 'Technology,': [2692], 'Boston,': [2694], '1:1,000,': [2697], '(Santa': [2700], 'Cruz': [2701], 'Biotechnology,': [2702], 'Santa': [2703], 'Cruz,': [2704], 'CA)': [2705], '1:2,000.': [2707], 'antigen-antibody': [2709], 'complexes': [2710], 'visualized': [2712], 'peroxidase-conjugated': [2714], 'anti-rabbit': [2715], '(1:5,000)': [2717], 'chemiluminescence': [2721], 'ECL': [2722], 'detection': [2723], 'system': [2724], '(Life': [2725, 2929], 'Technologies,': [2726, 2930, 2973], 'Grand': [2727, 2931, 2974], 'Island,': [2728, 2932, 2975], 'NY).': [2729, 2933], 'assays': [2731], 'duplicate.': [2735], 'Inguinal,': [2736], 'epididymal': [2737], 'WAT,': [2738], 'BAT': [2741, 2773, 2915, 3448, 4207], 'surgically': [2743], 'removed': [2744], '(n': [2750, 3413, 4370, 4423], '=': [2751, 3346, 3414, 4371, 4424], '3': [2752, 4457], 'per': [2753, 3212, 3416], 'group).': [2754], 'Freshly': [2755], 'dissected': [2756], 'pads': [2758], 'minced': [2760], 'size': [2763, 3475], '2–3': [2765], 'mm3': [2766, 2771], 'iWAT': [2768, 2913, 4167, 4190], '1–2': [2770], 'ice-cold': [2776], 'Petri': [2777], 'dish': [2778], 'Krebs-Ringer': [2780], 'HEPES': [2781, 2813], '(5': [2783], 'D-glucose,': [2785], '2%': [2786], 'BSA,': [2787], '135': [2788], '2.2': [2791], 'CaCl2,': [2793], '1.25': [2794], 'MgSO4,': [2796], '0.45': [2797], 'KH2PO4,': [2799], '2.17': [2800], 'Na2HPO4,': [2802], '10': [2804], 'HEPES)': [2806], 'rinsed': [2809, 2892], 'twice': [2810, 2895], 'Kreb-Ringer': [2812], 'once': [2816], 'DMEM': [2818, 2854], '10%': [2820], 'BSA.': [2821], 'Samples': [2822, 2922], 'passed': [2824], '200-μm': [2827], 'mesh.': [2828], '6-well': [2835], 'plate': [2836], 'equal': [2839], 'amount': [2840, 3577, 3584], 'well.': [2846], 'allowed': [2850], 'stabilize': [2852], 'medium': [2855], 'treatment.': [2861], 'under': [2866, 4067], 'sterile': [2867], 'conditions.': [2868], 'LY333,531': [2869], 'Alexus': [2871], 'Biochemicals': [2872], 'added': [2874], 'well': [2877], 'Explants': [2883], '2': [2888, 2941, 4118], 'ml': [2889], 'tube': [2890], 'PBS': [2894], 'being': [2897], 'snap-frozen': [2898], 'nitrogen': [2901], 'later': [2903], 'analysis': [2904, 3094, 3817, 4188], 'expression.': [2907], 'Total': [2908], 'RNA': [2909, 2945], 'extracted': [2911], 'homogenization': [2918], 'TRIzol': [2920], 'reagent.': [2921], 'treated': [2924], 'DNA-free': [2927], 'kit': [2928], 'first-strand': [2935], 'cDNA': [2936, 2968], 'synthesis,': [2937], 'constant': [2938], 'μg': [2942], 'reverse': [2947], 'transcribed': [2948], 'μl': [2952], 'final': [2953], 'volume': [2954], 'random': [2956], 'hexamers': [2957], 'primers': [2959], 'units': [2962], 'MultiScribe™': [2964], 'Reverse': [2965, 2969], 'Transcriptase': [2966], '(High-capacity': [2967], 'Transcription': [2970], 'Kit,': [2971], 'Life': [2972], 'NY)': [2976], 'transcript': [3050], 'levels': [3051, 3605, 3960], 'quantified': [3056], 'earlier.': [3059], 'Relative': [3060, 3387], 'mRNA': [3061], 'expressed': [3064], 'fold': [3066], 'triplicate,': [3077], 'average': [3080], 'values': [3081, 4462], 'calculated.': [3083], 'means': [3089, 3410, 4379], 'SEM.': [3091], 'statistical': [3093, 3459], 'Student': [3098], 't-test': [3099], 'ANOVA': [3101], 'Excel;': [3103], 'P': [3104], '<': [3105, 3419], '0.05': [3106], 'considered': [3108, 3465], 'significant.': [3109], 'phenotype,': [3119], 'intercrossed': [3121], 'ob−/+': [3122], 'compared': [3136, 3216, 3449, 3685, 3804, 3971, 4007, 4060, 4276, 4299], 'Compared': [3142, 3468], 'same': [3149], 'lower': [3154, 3966], '(Fig.': [3157, 3222, 3267, 3304, 3466, 3486, 3533, 3554, 3569, 3598, 3770, 3892, 3977, 3991, 4028, 4130, 4148, 4184, 4201, 4216, 4247, 4254, 4280, 4292, 4322, 4335], '1A–C).': [3158], 'Noteworthy': [3159], 'weights': [3163, 3252, 4085, 4098, 4113, 4154, 4204], 'apparent': [3165], 'early': [3168], '7': [3170, 4361], 'weeks': [3171, 3183, 4081, 4119], 'age': [3173], 'became': [3175], 'more': [3177, 3292, 4227, 4313], 'pronounced': [3178], 'aging.': [3180], 'At': [3181], '18': [3182], '34%': [3190], '29%': [3196], 'inguinal': [3206, 3235, 3272], 'depots': [3211], '1D,': [3223], 'E)': [3224], '(results': [3228, 3731], 'shown).': [3230], 'wet': [3232], '(iWAT)': [3239, 3274], '∼41%': [3243], 'comparison': [3247], 'including': [3256], 'liver': [3257, 3334, 3362, 3377, 3394, 3539, 3621], '(BAT),': [3262], 'genotypes': [3266, 3367, 3402, 4074, 4215], '1F,': [3268], 'G).': [3269], 'Histology': [3270], 'revealed': [3278, 4191, 4285], 'unilocular': [3279, 3506], 'adipocytes': [3281, 3478, 3490, 4193], 'smaller': [3284, 3297, 3481, 3551, 4192], 'than': [3285, 3765, 4140, 4194, 4231, 4244], 'those': [3286, 3545, 3973, 4195], 'abundant,': [3291], 'densely': [3293], 'much': [3296, 3480], 'many': [3299], 'multilocular': [3302, 3494], 'appearance': [3303, 4221], '2A).Fig.': [3305], '2Histological': [3306], 'biochemical': [3308], 'liver,': [3311, 3582], 'adipose,': [3312], 'TG': [3315, 3390, 3561, 3579, 3586, 3604, 3632, 3642, 4242], 'A:': [3323], 'Hematoxylin': [3324], '(H+E)': [3327], 'staining': [3328], 'iWAT,': [3330], 'BAT,': [3332], 'Results': [3341], 'representative': [3343], 'n': [3345], 'group.': [3350], 'Bar,': [3351], '5': [3352, 4425], 'μM.': [3353], 'B:': [3354], 'Thin-layer': [3355], 'chromatography': [3356], 'extracts': [3360], 'both': [3366, 3401], 'shown.': [3370], 'lane': [3372], 'represents': [3373, 3408], 'lipids': [3374], 'genotype.': [3385], 'contents': [3391], '(fasted': [3403], 'h).': [3405], 'value': [3407], 'SE': [3412, 4381], 'genotype).': [3417, 4375], '**P': [3418], '0.01.View': [3420], 'Large': [3421, 4387], 'Image': [3422, 4388], 'Figure': [3423, 4389], 'ViewerDownload': [3424, 4390], 'Hi-res': [3425, 4391], 'image': [3426, 4392], 'Download': [3427, 4393], '(PPT)': [3428], 'Brown': [3429], 'critical': [3432], 'adaptive': [3434], 'tend': [3441], 'absolute': [3445], 'difference': [3455, 4151], 'did': [3456], 'reach': [3458], 'significance': [3460], '1F).': [3467], '2A).': [3487, 3555], 'small': [3492], 'droplets': [3496], 'whereas': [3500, 3544], 'exhibited': [3503, 4144], 'droplets,': [3508], 'suggesting': [3509, 3734], 'higher': [3510, 3760, 3886, 4240], 'thermogenic': [3511], 'leading': [3516], 'reduction': [3518, 3630, 3638, 4165], 'accumulation.': [3521], 'massively': [3525], 'enlarged': [3526], 'engorged': [3530], '1G).': [3534], 'Histological': [3535, 4187], 'sections': [3536], 'lipid-filled': [3542, 3552], 'vacuoles,': [3543], 'vacuoles': [3553], 'histological': [3558], 'examination,': [3559], 'greatly': [3564], '2B,': [3570, 3599], 'C).': [3571, 3600], 'addition': [3573], 'skeletal': [3589], 'Therefore,': [3601], 'due': [3611, 3878], 'storage': [3615], 'muscle.': [3623], 'remains': [3625], 'seen': [3628, 3727], 'whether': [3629, 3664, 3790], 'biosynthesis': [3633], 'contributes': [3634], 'overall': [3637], "body's": [3641], 'contents.': [3643], 'Adiposity': [3644], 'influenced': [3646], 'rate': [3649, 3655, 3721, 3776, 3860, 4410], 'consumption': [3652, 3755, 3800, 3874, 4291, 4413], 'expanded': [3660], 'metabolically.': [3661], 'change': [3665], 'and/or': [3669], 'responsible': [3673], 'decreased': [3675, 4262], 'rates': [3687], 'oxygen': [3692, 3754, 3799, 3873, 4290, 4412], 'consumption.': [3693, 4351], 'With': [3694], 'without': [3696], 'normalization': [3697], 'weight,': [3700], 'Fig.': [3701], '3A': [3702], '3B': [3704], 'consumed': [3710], 'level': [3713], 'mice;': [3719], 'this': [3720, 4123], 'shown),': [3733], 'decrease': [3737, 4003], 'cannot': [3741, 3787], 'failure': [3745], 'gain': [3750], 'weight.': [3751], 'Interestingly,': [3752], 'basal': [3753], 'night': [3757, 4316], '3C,': [3771], 'D).': [3772, 4186], 'Thus,': [3773], 'help': [3778], 'normalize': [3780], 'rule': [3788], 'out': [3789], 'contribute': [3796], '(27Butler': [3808], 'A.A.': [3809], 'Kozak': [3810], 'L.P.': [3811], 'recurring': [3813], 'problem': [3814], 'models': [3823], 'expressing': [3824], 'phenotypes.Diabetes.': [3828], '59:': [3830, 3864], '323-329Crossref': [3831], '(216)': [3834], '28Kaiyala': [3837], 'K.J.': [3838], 'Morton': [3839], 'G.J.': [3840], 'Leroux': [3841], 'B.G.': [3842], 'Ogimoto': [3843], 'Wisse': [3845], 'Schwartz': [3847], 'M.W.': [3848], 'mass': [3853, 4170], 'major': [3856], 'determinant': [3857], 'mice.Diabetes.': [3862], '1657-1666Crossref': [3865], '(124)': [3868], 'could': [3875], 'part': [3880], 'maintenance': [3883], '3E).': [3893], 'strongly': [3896, 4179], 'increase': [3902, 4041, 4108, 4288, 4308], 'Changes': [3908], 'often': [3912], 'alterations': [3915], 'develop': [3924], 'form': [3926], 'type-2': [3932], 'diabetes,': [3933], 'condition': [3935], 'commonly': [3936], 'evaluate': [3941], 'chow-fed': [3951], 'first': [3954], 'evaluated': [3955], 'genotypes.': [3962], 'Both': [3963, 4073], '4A).': [3978], 'ratios': [3983], '4A),': [3992], 'indicating': [3993, 4018, 4174, 4338], 'sensitivity.': [3996], 'Meanwhile,': [3997], 'intraperitoneal': [4012], 'injection': [4013], 'insulin,': [4017], '4B).': [4029], 'agreement': [4031], 'findings,': [4035], 'whole': [4044], 'uptake,': [4047], 'further': [4048, 4161], 'supporting': [4049], '(Huang': [4053], 'al.,': [4055], 'unpublished': [4056], 'results).': [4057], 'responses': [4061], 'conditions': [4068], 'dietary': [4071, 4128], 'stress.': [4072], 'beginning': [4078], '8': [4080], 'age.': [4083], 'monitored': [4090, 4435], 'weekly,': [4091], 'end': [4095], 'various': [4103], 'parameters.': [4105], 'evident': [4115], 'HFD,': [4121], 'trend': [4124], 'continued': [4125], 'throughout': [4126], 'protocol': [4129], '5A,': [4131], 'B).': [4132], 'gained': [4137], 'less': [4138], 'obese-resistant': [4146], '5B).': [4149], 'reflected': [4162], 'rWAT': [4169], 'protected': [4180], 'HFD-induced': [4182], '5C,': [4185], '5C).': [4202], 'almost': [4211], 'comparable': [4212, 4328], '5E,': [4217], 'F).': [4218], 'Liver': [4219], 'whitish': [4228], 'color': [4230], 'Similarly,': [4236], '5G)': [4248], 'glucose/insulin': [4252], 'ratio': [4253], '5H).': [4255], 'again': [4258], 'clear': [4259], '6).': [4281], 'Indirect': [4282], 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