Publication Information

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2802, 2858], 'Lee': [176, 260, 444, 540, 662, 683, 1067, 1105, 1192, 1240, 1323, 1553, 1862, 1893, 2263, 2277, 2281], 'et': [177, 445, 541, 663, 684, 963, 1068, 1106, 1193, 1241, 1324, 1554, 1863, 1894, 2908], 'al,13': [178], 'who,': [179], 'this': [181, 731, 870, 998, 1075, 1215, 1408, 1560, 1587, 1665, 1837, 1849, 1955], 'issue': [182], 'Circulation': [184], 'Research,': [185], 'present': [186], 'first': [188, 1383], 'evidence': [189, 1035, 1417, 1585, 1649], 'may': [193, 393, 520, 774, 808, 955, 1081, 1483, 1626, 1666, 1780, 1839, 1845, 1851, 1913, 1932], 'require': [194], 'additional': [195], 'factors': [196, 947], 'mechanisms.': [198], 'They': [199], 'found': [200, 965, 1055, 1161], 'Thy-1': [202, 691, 970, 977, 1050, 1093, 1116, 1140, 1158, 1310, 1327, 1338, 1445, 1625, 1675, 1707, 1713, 1726, 1768, 1844, 2701], 'was': [203, 220, 503, 1634, 1896], 'upregulated': [204, 1340, 2291], 'newly': [206, 1783], 'formed': [207, 1784], 'four': [211, 232, 972], 'models': [212, 233, 973, 1125], 'rats,': [217], 'whereas': [218], 'it': [219, 387, 1101, 1252, 1269, 1423, 1457, 1482, 1779], 'not': [221, 511, 529, 554, 996, 1082, 1117, 1170, 1271, 1315, 1454, 1765, 1846, 1905], 'expressed': [222, 1164], 'vasculogenesis': [224, 2221], 'embryo.': [229], 'Notably,': [230], 'included': [234], '(tumor,': [237], 'balloon': [238], 'injury,': [239, 815], 'ligation': [241], 'renal': [243], 'artery)': [244], '(uterine': [247], 'pregnancy)': [250], 'One': [252], 'conclusions': [255], 'work': [258, 1891], 'at': [261, 448, 884, 936], 'al': [262, 664, 685, 1107, 1194, 1242, 1325, 1864], 'therefore': [264], 'endothelium': [268, 284, 302, 326, 797, 1388, 2862], 'differs': [269], 'endothelium.There': [273], 'precedence': [275], 'for': [276, 418, 465, 508, 512, 959, 1036, 1097, 1198, 1586, 1702, 1742, 1790, 2289, 2774, 2914], 'differences': [277], 'between': [278, 636, 1001], '"young"': [279], '"old"': [281], 'endothelium.': [282, 322, 2168, 2303], 'Adult': [283], 'mature': [290], '(ie,': [291], 'complete': [293], 'basal': [295], 'lamina': [296], 'most': [298, 1535], '"thin"': [301], 'smooth': [304, 1180], 'luminal': [305], 'abluminal': [307], 'surfaces),': [308], 'expresses': [310], 'organ-specific': [311], 'characteristics.14': [312], 'It': [313, 1070, 1183, 1209, 1798], 'is,': [314, 1412], 'general,': [316], 'much': [317, 1671], 'less': [318, 1335], '"plastic"': [319], 'than': [320, 839, 1344], 'dorsal': [329], 'aorta': [330], 'can': [331, 734], 'be': [332, 394, 506, 623, 652, 735, 775, 957, 1083, 1163, 1203, 1212, 1333, 1364, 1381, 1405, 1484, 1564, 1573, 1627, 1667, 1700, 1840, 1847, 1852, 1914, 1950], 'transplanted': [333], 'into': [334], 'brain': [336, 1312, 2860], 'differentiate': [338], 'blood-brain': [340, 1291, 2851], 'barrier': [341, 1292], 'endothelium.15': [342], 'There': [343, 994], 'also': [345, 588, 722, 1010, 1122, 1176, 1781], 'massive': [346], 'remodeling,': [347], 'pruning,': [348], 'angioblast': [350], 'migration': [351], 'occurring': [352], 'system': [357, 381, 1838], 'virtually': [360], 'absent': [361, 1204], 'adult.': [364], 'The': [365, 481, 845, 1534, 1614, 2323], 'tentative': [366], 'proposal': [367], 'these': [369, 452, 615, 726, 748, 1005, 1696], 'observations': [370, 751, 907], 'adjusted': [378], 'need,': [384], 'established': [386], 'certain': [390, 1129], 'degree,': [391], 'refractory': [395], 'new': [397, 842, 943, 1774, 1802], 'formation.1': [400], 'concept': [402], 'supported': [404], 'studies': [406, 1132, 1285, 1688], 'on': [407, 880, 1023, 1041, 1056, 1677, 1994, 2463, 2704], 'inhibitors.': [409], 'no': [411, 1334, 1415], 'molecular': [412, 2878], 'mechanism': [413], 'action': [415, 914], 'known': [417, 455, 569, 984, 1562, 1723, 1800], 'angiostatin,': [419], 'endostatin,': [420], 'thrombospondin,': [422], 'all': [424], 'been': [426, 601, 620, 649, 659, 1160, 1402, 1661], 'reported': [427, 504], 'previous': [429], 'studies161718': [430], 'inhibit': [432], 'vivo': [436, 2242], 'model': [437, 703, 1298], 'systems': [438], 'those': [441], 'used': [442, 1190, 1251], 'al.13': [446], 'Coincidentally,': [447], 'present,': [449], 'none': [450], 'inhibitors': [453, 519, 1830], 'play': [457, 521, 673], 'role': [459, 523, 676, 868, 1353, 1519, 2028], 'Mice': [463, 2497], 'deficient': [464], 'thrombospondin': [466, 2500], 'plasminogen': [468, 2461], '(of': [469], 'which': [470, 630, 1571], 'angiostatin': [471], 'fragment)': [474], 'display': [475, 2502], 'an': [476, 788, 800, 852, 866, 1447, 2393, 2513], 'apparently': [477], 'circulation.1920': [480], 'thrombospondin-2': [482], 'knockout': [483, 1615, 1697, 1868], 'particularly': [485, 1143], 'interesting': [486], 'because': [487, 1077], 'twice': [488], 'many': [490], 'were': [493, 1090, 1339, 1904], 'counted': [494], 'mutant': [496], 'compared': [497], 'wild-type': [499], 'tissues.': [500], 'difference': [502, 635, 1000], 'significant': [507], 'but': [510, 528, 1007, 1121, 1175, 1314, 1410, 1664, 1778], 'neonatal': [515], 'tissue.20': [516], 'shaping': [525], 'postnatal': [527], 'system.The': [533], 'second': [534], 'conclusion': [535], 'study': [538], 'al13': [542, 964, 1555, 1895], 'hypothesized': [546], 'earlier,1': [547], 'accompanied': [551], 'by,': [552], 'if': [553, 1088, 1337, 1952], 'dependent': [555], 'on,': [556], 'inflammation.': [557], 'Inflammatory': [558, 641], 'cytokines': [559], 'necrosis': [562, 2733, 2804], '[TNF],': [564], 'interleukin-1,': [565], 'interleukin-8)': [567], 'upregulate': [571], 'number': [573, 1135, 1673], 'cells,': [578, 642, 647, 697, 1200, 1346, 1559], 'resulting': [579], 'so-called': [581], 'activated': [582, 789, 795], 'endothelium.21': [583], 'Furthermore,': [584], 'inflammatory': [585, 744, 757, 765, 1238, 1441, 2293], 'cytokines,': [586], 'induced': [591, 1828, 2136], 'them': [593], 'soluble': [598, 1259, 2182, 2580], 'selectins),': [599], 'shown': [602, 621, 650, 681], 'stimulate': [604], 'vitro': [608], 'vivo.222324': [612], 'None': [613], 'has,': [617], 'so': [618], 'far,': [619], 'consistent': [632, 864, 967, 1516, 1536, 1574], 'eg,': [643, 1687], 'monocytes/macrophages': [644], 'mast': [646], 'angiogenesis25': [656], 'detected': [660], 'their': [666], 'models.': [667], 'Macrophage-derived': [668], 'TNF': [669, 877, 888], 'believed': [671, 1362], 'major': [675], 'wound-healing': [678], 'angiogenesis.2627': [679], 'TNF,': [680], 'others28': [687], 'specifically': [689], 'induce': [690, 2629], 'capillaries': [693, 807, 1331, 1803], 'cultured': [695], 'angiogenic': [699, 772, 1330, 1443, 1716, 1796, 2747], 'cornea': [702], 'angiogenesis2930': [705], 'stimulates': [707], 'cell': [709, 715, 882, 1046, 1468, 2586, 2742], 'chemotaxis31': [710], 'but,': [711], 'paradoxically,': [712], 'inhibits': [713, 1264], 'proliferation.29': [716], 'Provided': [717], 'latter': [720], 'activity': [721, 733, 848], 'works': [723], 'vivo,': [725], 'results': [727, 1078], 'would': [728, 1332, 1572, 1699, 1734], 'suggest': [729, 763, 1138, 1735], 'inhibitory': [732], 'overcome': [736], 'counteracting': [738, 874], 'stimulators30': [739], 'released': [740], 'simultaneously': [741], 'response': [745, 758, 1439, 1538, 1611, 1741], 'noted': [746], 'corneas.29': [749], 'These': [750, 906], 'underline': [752], 'importance': [754], 'mediators,': [766], 'either': [767], 'alone': [768], 'together': [770], 'factors,': [773], 'necessary': [776], 'shift': [778], 'balance': [780], 'fixed': [783], 'quiescent': [784], 'proangiogenic': [790], 'endothelium.The': [791], 'earliest': [792], 'event': [793], 'usually': [799], 'increase': [801, 822, 1545], 'permeability.': [804], 'react': [809], 'situations': [812], 'like': [813, 1375], 'ischemia,': [814], 'inflammation,': [816], 'neoplasia': [818], 'rapid': [821, 912], 'permeability': [824, 856, 898, 934], 'order': [826], 'accelerate': [828], 'delivery': [830], 'nutrients': [832], 'oxygen': [834], '(and': [835], 'perhaps': [836, 1882], 'leukocytes)': [837], 'rather': [838, 1343], 'making': [841], 'vessels.': [844, 945, 2314], 'potent': [846, 2738], 'biological': [847], 'VEGF': [850, 879, 892, 929, 2110, 2142], 'enhancer': [853], '(with': [859], 'notable': [860, 1185], 'kinetic': [861], 'differences)': [862], 'early': [867], 'factor.32': [871], 'Unlike': [872], 'activities': [875], 'least': [885, 937], 'vitro,': [887, 2745], 'strongly': [889], 'synergizes': [890], 'induction': [895], '(Matthias': [899], 'Clauss,': [900], 'PhD,': [901, 1961], 'oral': [902], 'communication,': [903], 'March': [904], '1998).': [905], 'compatible': [909], 'compensatory': [913], 'tissue': [920, 1014, 2504], 'ischemia': [921], 'hypoxia': [923], 'mediated': [926, 1539, 2578, 2801], 'hypoxia-inducible': [928], 'increasing': [931], 'while,': [935], 'initially,': [938], 'suppressing': [939], 'Additional': [946], 'angiopoietins;': [949], 'see': [950, 1396], 'below)': [951], 'and/or': [952, 1428, 1680], 'sustained': [953], 'activation': [954], 'then': [956], 'required': [958], 'ensue.Lee': [962], 'upregulation': [968, 1114, 1328], '25-kD': [980], 'glycosylphosphatidylinositol-linked': [981], 'membrane': [982, 1503], 'glycoprotein,': [983], 'since': [985, 990], '1964': [986], 'mice': [988, 1698, 2978, 3009], '1980': [991], 'humans.': [993], 'only': [997, 1057, 1118, 1171, 1766], 'time': [999], 'identification': [1003], 'species,': [1006], 'there': [1008, 1033, 1411], 'distinct': [1012], 'species-specific': [1013], 'distribution': [1015, 1141], 'Thy-1.': [1017, 2980], 'In': [1018, 1048, 1371, 1420, 1480, 1557], 'mice,': [1019], 'expression': [1020, 1051, 1308, 2677], 'seen': [1022, 1113], 'T': [1024, 1655, 1678], 'lymphocytes': [1025], 'central': [1029], 'nervous': [1030], 'system,': [1031], 'inducibility': [1037], 'molecule': [1040, 1464, 2712], 'variety': [1043], 'hematopoietic': [1045, 1062], 'lines.': [1047], 'contrast,': [1049], 'humans': [1053, 1087], 'small': [1059], 'proportion': [1060], '(see': [1064, 1148, 1550], 'references': [1065, 1152, 1551], 'al).': [1069], 'important': [1072, 1103, 1336], 'stress': [1074], 'point,': [1076], 'rodents': [1080], 'easily': [1084], 'transferable': [1085], 'use': [1092], 'target': [1096], 'antiangiogenic': [1098], 'therapies.': [1099], 'Thus,': [1100], 'point': [1108], 'out': [1109], 'rats': [1120], 'mouse': [1124], 'Despite': [1128, 1833], 'species': [1130, 1137], 'differences,': [1131], 'related': [1144], 'Reference': [1149, 1397], '2828': [1150], 'therein).': [1153], 'However,': [1154, 1268, 1583], 'within': [1155], 'somewhat': [1167], 'heterogeneous': [1168], 'pattern': [1169], 'pericytes': [1178, 1275, 1313, 1342, 1355, 1427], 'muscle': [1181], 'cells.': [1182, 2033], 'von': [1187], 'Willebrand': [1188], 'factor,': [1189], 'marker': [1197, 1772, 2288], 'appeared': [1201], 'Thy-1–positive': [1207], 'capillaries.': [1208, 1582], 'remains': [1210], 'investigated': [1213], 'whether': [1214], 'due': [1217, 1668], 'downregulation,': [1220], 'depletion': [1222], 'Weibel-Palade': [1224], 'bodies': [1225], 'subsequent': [1228], 'inhibition': [1229, 2974], 'synthesis,': [1231], 'other': [1233, 1524], 'triggered': [1235], 'response.': [1239], 'show': [1243, 3010], 'immunohistochemistry': [1244], 'high': [1246, 1511], 'technical': [1247], 'quality': [1248], 'demonstrate': [1254], 'specificity': [1255], 'preparing': [1257], 'dimeric': [1260], 'Thy-1–immunoglobulin': [1261, 1859], 'chimera': [1262, 1860], 'specific': [1266, 1306, 1685], 'staining.': [1267], 'easy': [1272], 'distinguish': [1274], 'using': [1279, 1857, 1867], 'methodology': [1281], 'applied.': [1282], 'Our': [1283], 'own': [1284], 'involving': [1286, 1689], 'immune': [1288], 'rat': [1297, 2859], 'experimental': [1300], 'autoimmune': [1301], 'encephalomyelitis': [1302], 'clearly': [1304], 'revealed': [1305], 'constitutive': [1307], 'cells.33': [1318], 'Nevertheless,': [1319], 'observation': [1321], 'given': [1347], 'discussions': [1350], 'angiopoietins': [1357], 'Pericytes': [1360], 'safeguards': [1366], 'against': [1367], 'uncontrolled': [1368], 'proliferation.': [1370, 2631], 'some': [1372], 'situations,': [1374], 'diabetic': [1376], 'retinopathy,': [1377], 'seem': [1379, 1505], 'migrate': [1385], 'going': [1391], 'proliferate': [1393], '(for': [1394], 'review,': [1395], '3434': [1398], ').': [1399, 1556], 'Angiopoietins': [1400], 'proposed': [1403], 'process,': [1409], 'yet,': [1414, 1663], 'direct': [1416, 1584], 'this.3536': [1419], 'any': [1421], 'case,': [1422], 'conceivable': [1425], 'integration': [1435], 'capillary': [1438], 'factors.Although': [1444], 'impressive': [1448], 'publication': [1449], 'record,': [1450], 'clear.': [1455], 'Currently,': [1456], 'best': [1459], 'described': [1460, 1662], 'multifunctional': [1463], 'possibly': [1465], 'adhesion,': [1469], 'signaling,': [1470], 'differentiation.37': [1473], 'No': [1474, 1657], 'counterreceptor': [1475], 'ligand': [1477, 2773], 'known.': [1479], 'capillaries,': [1481], 'adhesion': [1487, 2542, 2587], '(or': [1488], 'antiadhesion?)': [1489], 'another,': [1495], 'pericytes,': [1497], 'leukocytes.': [1500, 1533], 'Glycosylphosphatidyl-': [1501], 'inositol-linked': [1502], 'potential': [1509], 'lateral': [1512], 'mobility': [1513], 'membranes,': [1515], 'rapidly': [1521], 'associating': [1522], '(trans)membrane': [1525], 'proteins': [1526], 'mediating': [1529], 'transmigration': [1531], 'signaling': [1537, 1605, 1652, 2711, 3013], 'antibody': [1541], 'cross-linking': [1542], 'intracellular': [1547], 'calcium': [1548], 'flux': [1549], 'increases': [1567], 'permeability,': [1570], 'phenotype': [1577, 1616, 1647, 1659, 1729], 'lacking,': [1593], 'light': [1596], 'absence': [1599], 'natural': [1601, 2181, 2912], 'ligands': [1602], 'molecules,': [1606], 'significance': [1608], 'unclear.': [1613], 'Thy-1−/−': [1618, 1757], 'complex': [1620], 'suggests': [1622], 'instead': [1623], 'negative': [1629], 'regulator.3839': [1630], 'neuronal': [1632], 'defect': [1633, 1653], 'correlated': [1635], 'regional': [1637, 2973], 'impairment': [1638], 'long-term': [1640], 'potentiation,38': [1641], 'analysis': [1643], 'immunological': [1646], 'uncovered': [1648], 'cells.39': [1656], 'larger': [1672], 'lack': [1683, 2499], 'studies,': [1686], 'healing': [1691], 'growth.': [1694], 'Obviously,': [1695], 'ideal': [1701], 'testing': [1703], 'angiogenesis.What': [1710], 'perform': [1714], 'capillaries?': [1717], 'On': [1718], 'basis': [1720], 'properties': [1724], 'Thy-1-deficient': [1731], 'mice,37': [1732], 'modulation': [1737], 'stimulating': [1740], 'proliferation,': [1744], 'similar': [1745], 'enhanced': [1748], 'mitogenic': [1749], 'stimulation': [1750], 'through': [1751], 'T-cell': [1753, 2935], 'antigen': [1754], 'receptor': [1755, 2159, 2777], 'mice.': [1758, 2224, 2469], 'An': [1759], 'alternative': [1760], 'intriguing': [1761], 'possibility': [1762, 1835], 'does': [1767], 'serve': [1769], 'mark': [1782], 'regression': [1791, 1827], 'after': [1792, 1807], 'cessation': [1793], 'stimulus.': [1797], 'wounds': [1805], 'regress': [1806, 1811], 'closure,': [1809], 'luteum': [1815], 'cyclic': [1818], 'fashion,': [1819], 'prone': [1825], 'redundant': [1841], 'essential,': [1848], 'hypothesis': [1850], 'subject': [1853], 'investigation': [1855], 'mice.It': [1869], 'hoped': [1871], 'research': [1874, 1936, 1993], 'will': [1875], 'eventually': [1876], 'cure': [1877], 'ease': [1880], 'prolong': [1883], 'life.': [1884], 'Edgar': [1885], 'Haber,': [1886], 'whose': [1888], 'laboratory': [1889], 'performed,': [1897], 'deceased.': [1899], 'Readers': [1900], 'colleagues': [1902], 'who': [1903], 'fortunate': [1906], 'enough': [1907], 'know': [1909], 'him,': [1910], 'myself,': [1912], 'referred': [1915], 'Mark': [1917], "Fishman's": [1918], 'obituary': [1919], 'Trends': [1921, 2034], 'Cardiovascular': [1923], 'Medicine': [1924], '(1998;8:6–7).': [1925], 'scientists,': [1927], 'death': [1928], 'colleague': [1931], 'remind': [1933], 'us': [1934], 'performed': [1938], 'human': [1940], 'beings': [1941], 'life': [1944], 'scientist': [1947], 'might': [1948], 'sometimes': [1949], 'easier': [1951], 'we': [1953], 'keep': [1954], 'mind.FootnotesCorrespondence': [1957], 'Risau,': [1960], 'Max-Planck-Institut': [1962], 'für': [1963], 'physiologische': [1964], 'und': [1965], 'klinische': [1966], 'Forschung,': [1967], 'W.G.': [1968], 'Kerchoff-Institut,': [1969], 'Parkstrasse': [1970], '1,': [1971], 'D-61231': [1972], 'Bad': [1973], 'Nauheim,': [1974], 'Germany.': [1975], 'E-mail': [1976], '[email': [1977], 'protected]': [1978], 'References': [1979], '1': [1980], 'W.': [1982, 2009, 2300], 'Mechanisms': [1983], 'Nature.1997;': [1986], '386:671–674.CrossrefMedlineGoogle': [1987], 'Scholar2': [1988], 'Folkman': [1989, 2352, 2390], 'J.': [1990, 2353, 2391], 'Clinical-applications': [1991], 'N': [1996], 'Engl': [1997], 'J': [1998, 2521, 2614, 2718, 2865], 'Med.1995;': [1999], '333:1757–1763.CrossrefMedlineGoogle': [2000], 'Scholar3': [2001], 'Breier': [2002, 2071], 'G,': [2003, 2072, 2175, 2381], 'Damert': [2004], 'A,': [2005, 2082, 2691, 2760], 'Plate': [2006, 2232], 'KH,': [2007, 2233], 'Angiogenesis': [2010, 2577], 'embryos': [2012, 2106], 'ischemic': [2014], 'diseases.': [2015], 'Thromb': [2016], 'Haemost.1997;': [2017], '78:678–683.CrossrefMedlineGoogle': [2018], 'Scholar4': [2019], 'Carmeliet': [2020, 2067, 2444], 'P,': [2021, 2068, 2445, 2729, 2993], 'Collen': [2022, 2093, 2454], 'D.': [2023, 2455, 2924], 'Genetic-analysis': [2024], 'blood-vessel': [2026], 'formation:': [2027], 'versus': [2031], 'smooth-muscle': [2032], 'Cardiovasc': [2035], 'Med.1997;': [2036], '7:271–281.CrossrefMedlineGoogle': [2037], 'Scholar5': [2038], 'Kim': [2039], 'KJ,': [2040, 2130], 'Li': [2041], 'B,': [2042, 2229, 2822, 2844], 'Winer': [2043], 'J,': [2044, 2090, 2150, 2205, 2899, 2962], 'Armanini': [2045], 'M,': [2046, 2078, 2080, 2122, 2152, 2209, 2347, 2490, 2723, 2946, 3003], 'Gillett': [2047], 'N,': [2048, 2116, 2379, 2553, 2903, 2997], 'Phillips': [2049], 'HS,': [2050], 'Ferrara': [2051, 2115], 'N.': [2052, 2797, 2934], 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