Publication Information

{'id': 'https://openalex.org/W2096158347', 'doi': 'https://doi.org/10.1523/jneurosci.23-05-01605.2003', 'title': 'Interleukin-1 Mediates Pathological Effects of Microglia on Tau Phosphorylation and on Synaptophysin Synthesis in Cortical Neurons through a p38-MAPK Pathway', 'display_name': 'Interleukin-1 Mediates Pathological Effects of Microglia on Tau Phosphorylation and on Synaptophysin Synthesis in Cortical Neurons through a p38-MAPK Pathway', 'publication_year': 2003, 'publication_date': '2003-03-01', 'ids': {'openalex': 'https://openalex.org/W2096158347', 'doi': 'https://doi.org/10.1523/jneurosci.23-05-01605.2003', 'mag': '2096158347', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/12629164', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/3833596'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1523/jneurosci.23-05-01605.2003', 'pdf_url': 'https://www.jneurosci.org/content/jneuro/23/5/1605.full.pdf', 'source': {'id': 'https://openalex.org/S5555990', 'display_name': 'Journal of Neuroscience', 'issn_l': '0270-6474', 'issn': ['0270-6474', '1529-2401'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319739', 'host_organization_name': 'Society for Neuroscience', 'host_organization_lineage': ['https://openalex.org/P4310319739'], 'host_organization_lineage_names': ['Society for Neuroscience'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://www.jneurosci.org/content/jneuro/23/5/1605.full.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5020715597', 'display_name': 'Yuekui Li', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Yuekui Li', 'raw_affiliation_strings': ['Departments of Geriatrics and'], 'affiliations': [{'raw_affiliation_string': 'Departments of Geriatrics and', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100344005', 'display_name': 'Ling Liu', 'orcid': 'https://orcid.org/0000-0002-8681-3656'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Ling Liu', 'raw_affiliation_strings': ['Departments of Geriatrics and'], 'affiliations': [{'raw_affiliation_string': 'Departments of Geriatrics and', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5040994368', 'display_name': 'Steven W. Barger', 'orcid': 'https://orcid.org/0000-0001-6049-6480'}, 'institutions': [{'id': 'https://openalex.org/I79620101', 'display_name': 'University of Arkansas for Medical Sciences', 'ror': 'https://ror.org/00xcryt71', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I79620101']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Steven W. Barger', 'raw_affiliation_strings': ['Anatomy, University of Arkansas for Medical Sciences, and', 'Department of Veterans Affairs Medical Center and', 'Departments of Geriatrics and', 'Geriatric and'], 'affiliations': [{'raw_affiliation_string': 'Department of Veterans Affairs Medical Center and', 'institution_ids': []}, {'raw_affiliation_string': 'Anatomy, University of Arkansas for Medical Sciences, and', 'institution_ids': ['https://openalex.org/I79620101']}, {'raw_affiliation_string': 'Departments of Geriatrics and', 'institution_ids': []}, {'raw_affiliation_string': 'Geriatric and', 'institution_ids': []}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5021533014', 'display_name': 'W. Sue T. Griffin', 'orcid': 'https://orcid.org/0000-0002-0405-7800'}, 'institutions': [{'id': 'https://openalex.org/I79620101', 'display_name': 'University of Arkansas for Medical Sciences', 'ror': 'https://ror.org/00xcryt71', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I79620101']}, {'id': 'https://openalex.org/I4210119030', 'display_name': 'Mental Illness Research, Education and Clinical Centers', 'ror': 'https://ror.org/02hd1sz82', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1322918889', 'https://openalex.org/I2799886695', 'https://openalex.org/I4210119030']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'W. Sue T. Griffin', 'raw_affiliation_strings': ['Anatomy, University of Arkansas for Medical Sciences, and', 'Department of Veterans Affairs Medical Center and', 'Departments of Geriatrics and', 'Geriatric and', 'Mental Illness Research Education Clinical Centers, Little Rock, Arkansas 72205'], 'affiliations': [{'raw_affiliation_string': 'Anatomy, University of Arkansas for Medical Sciences, and', 'institution_ids': ['https://openalex.org/I79620101']}, {'raw_affiliation_string': 'Geriatric and', 'institution_ids': []}, {'raw_affiliation_string': 'Department of Veterans Affairs Medical Center and', 'institution_ids': []}, {'raw_affiliation_string': 'Departments of Geriatrics and', 'institution_ids': []}, {'raw_affiliation_string': 'Mental Illness Research Education Clinical Centers, Little Rock, Arkansas 72205', 'institution_ids': ['https://openalex.org/I4210119030']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 8.896, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 508, 'citation_normalized_percentile': {'value': 0.999917, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '23', 'issue': '5', 'first_page': '1605', 'last_page': '1611'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10086', 'display_name': "Alzheimer's disease research and treatments", 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10086', 'display_name': "Alzheimer's disease research and treatments", 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11266', 'display_name': 'Neuroinflammation and Neurodegeneration Mechanisms', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/2808', 'display_name': 'Neurology'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11337', 'display_name': 'Tryptophan and brain disorders', 'score': 0.9839, 'subfield': {'id': 'https://openalex.org/subfields/2803', 'display_name': 'Biological Psychiatry'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/synaptophysin', 'display_name': 'Synaptophysin', 'score': 0.92222345}, {'id': 'https://openalex.org/keywords/tau-protein', 'display_name': 'Tau protein', 'score': 0.5587444}], 'concepts': [{'id': 'https://openalex.org/C2777209535', 'wikidata': 'https://www.wikidata.org/wiki/Q14864388', 'display_name': 'Synaptophysin', 'level': 3, 'score': 0.92222345}, {'id': 'https://openalex.org/C2779830541', 'wikidata': 'https://www.wikidata.org/wiki/Q1622829', 'display_name': 'Microglia', 'level': 3, 'score': 0.82976687}, {'id': 'https://openalex.org/C51551487', 'wikidata': 'https://www.wikidata.org/wiki/Q2043632', 'display_name': 'p38 mitogen-activated protein kinases', 'level': 4, 'score': 0.6045699}, {'id': 'https://openalex.org/C2778670691', 'wikidata': 'https://www.wikidata.org/wiki/Q419507', 'display_name': 'Tau protein', 'level': 4, 'score': 0.5587444}, {'id': 'https://openalex.org/C57074206', 'wikidata': 'https://www.wikidata.org/wiki/Q14197552', 'display_name': 'MAPK/ERK pathway', 'level': 3, 'score': 0.5226364}, {'id': 'https://openalex.org/C11960822', 'wikidata': 'https://www.wikidata.org/wiki/Q242736', 'display_name': 'Phosphorylation', 'level': 2, 'score': 0.5048695}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.4734763}, {'id': 'https://openalex.org/C169760540', 'wikidata': 'https://www.wikidata.org/wiki/Q207011', 'display_name': 'Neuroscience', 'level': 1, 'score': 0.4482654}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.37484342}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.33335105}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.23403737}, {'id': 'https://openalex.org/C502032728', 'wikidata': 'https://www.wikidata.org/wiki/Q11081', 'display_name': "Alzheimer's disease", 'level': 3, 'score': 0.2018696}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.14238238}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.13685289}, {'id': 'https://openalex.org/C2776914184', 'wikidata': 'https://www.wikidata.org/wiki/Q101991', 'display_name': 'Inflammation', 'level': 2, 'score': 0.12661895}, {'id': 'https://openalex.org/C204232928', 'wikidata': 'https://www.wikidata.org/wiki/Q899285', 'display_name': 'Immunohistochemistry', 'level': 2, 'score': 0.119618416}, {'id': 'https://openalex.org/C2779134260', 'wikidata': 'https://www.wikidata.org/wiki/Q12136', 'display_name': 'Disease', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D007375', 'descriptor_name': 'Interleukin-1', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D017628', 'descriptor_name': 'Microglia', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D020928', 'descriptor_name': 'Mitogen-Activated Protein Kinases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D009474', 'descriptor_name': 'Neurons', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D016708', 'descriptor_name': 'Synaptophysin', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D016875', 'descriptor_name': 'tau Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D016564', 'descriptor_name': 'Amyloid beta-Protein Precursor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016564', 'descriptor_name': 'Amyloid beta-Protein Precursor', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002450', 'descriptor_name': 'Cell Communication', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D002450', 'descriptor_name': 'Cell Communication', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002478', 'descriptor_name': 'Cells, Cultured', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002540', 'descriptor_name': 'Cerebral Cortex', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': False}, {'descriptor_ui': 'D002540', 'descriptor_name': 'Cerebral Cortex', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018920', 'descriptor_name': 'Coculture Techniques', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D053590', 'descriptor_name': 'Interleukin 1 Receptor Antagonist Protein', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007375', 'descriptor_name': 'Interleukin-1', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007375', 'descriptor_name': 'Interleukin-1', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D007375', 'descriptor_name': 'Interleukin-1', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D008070', 'descriptor_name': 'Lipopolysaccharides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008070', 'descriptor_name': 'Lipopolysaccharides', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017628', 'descriptor_name': 'Microglia', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D017628', 'descriptor_name': 'Microglia', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': False}, {'descriptor_ui': 'D017628', 'descriptor_name': 'Microglia', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020928', 'descriptor_name': 'Mitogen-Activated Protein Kinases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009474', 'descriptor_name': 'Neurons', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D009474', 'descriptor_name': 'Neurons', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': False}, {'descriptor_ui': 'D009474', 'descriptor_name': 'Neurons', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018696', 'descriptor_name': 'Neuroprotective Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018696', 'descriptor_name': 'Neuroprotective Agents', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D010766', 'descriptor_name': 'Phosphorylation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010766', 'descriptor_name': 'Phosphorylation', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D051381', 'descriptor_name': 'Rats', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017207', 'descriptor_name': 'Rats, Sprague-Dawley', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012795', 'descriptor_name': 'Sialoglycoproteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012795', 'descriptor_name': 'Sialoglycoproteins', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D016708', 'descriptor_name': 'Synaptophysin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014409', 'descriptor_name': 'Tumor Necrosis Factor-alpha', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014409', 'descriptor_name': 'Tumor Necrosis Factor-alpha', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D014409', 'descriptor_name': 'Tumor Necrosis Factor-alpha', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': False}, {'descriptor_ui': 'D014409', 'descriptor_name': 'Tumor Necrosis Factor-alpha', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}, {'descriptor_ui': 'D048051', 'descriptor_name': 'p38 Mitogen-Activated Protein Kinases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016875', 'descriptor_name': 'tau Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1523/jneurosci.23-05-01605.2003', 'pdf_url': 'https://www.jneurosci.org/content/jneuro/23/5/1605.full.pdf', 'source': {'id': 'https://openalex.org/S5555990', 'display_name': 'Journal of Neuroscience', 'issn_l': '0270-6474', 'issn': ['0270-6474', '1529-2401'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319739', 'host_organization_name': 'Society for Neuroscience', 'host_organization_lineage': ['https://openalex.org/P4310319739'], 'host_organization_lineage_names': ['Society for Neuroscience'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3833596', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc3833596', 'pdf_url': 'https://europepmc.org/articles/pmc3833596?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/12629164', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1523/jneurosci.23-05-01605.2003', 'pdf_url': 'https://www.jneurosci.org/content/jneuro/23/5/1605.full.pdf', 'source': {'id': 'https://openalex.org/S5555990', 'display_name': 'Journal of Neuroscience', 'issn_l': '0270-6474', 'issn': ['0270-6474', '1529-2401'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319739', 'host_organization_name': 'Society for Neuroscience', 'host_organization_lineage': ['https://openalex.org/P4310319739'], 'host_organization_lineage_names': ['Society for Neuroscience'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'score': 0.53, 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 35, 'referenced_works': ['https://openalex.org/W1501075116', 'https://openalex.org/W1510591818', 'https://openalex.org/W1657989568', 'https://openalex.org/W1762207349', 'https://openalex.org/W1847890422', 'https://openalex.org/W1974284351', 'https://openalex.org/W1976385326', 'https://openalex.org/W1984307826', 'https://openalex.org/W1990752558', 'https://openalex.org/W1991763618', 'https://openalex.org/W1995515835', 'https://openalex.org/W2001327864', 'https://openalex.org/W2007158999', 'https://openalex.org/W2008767130', 'https://openalex.org/W2009592710', 'https://openalex.org/W2012076369', 'https://openalex.org/W2015163544', 'https://openalex.org/W2023235828', 'https://openalex.org/W2029555926', 'https://openalex.org/W2053116497', 'https://openalex.org/W2061194161', 'https://openalex.org/W2063407739', 'https://openalex.org/W2065656296', 'https://openalex.org/W2071695496', 'https://openalex.org/W2073730363', 'https://openalex.org/W2079026827', 'https://openalex.org/W2084043574', 'https://openalex.org/W2093489701', 'https://openalex.org/W2124546618', 'https://openalex.org/W2131897453', 'https://openalex.org/W2144118537', 'https://openalex.org/W2156326104', 'https://openalex.org/W2167818155', 'https://openalex.org/W2291628530', 'https://openalex.org/W4296391647'], 'related_works': ['https://openalex.org/W4236853434', 'https://openalex.org/W4205370713', 'https://openalex.org/W2419118008', 'https://openalex.org/W2376631516', 'https://openalex.org/W2086458565', 'https://openalex.org/W2086224696', 'https://openalex.org/W2071037804', 'https://openalex.org/W2067160292', 'https://openalex.org/W2056415482', 'https://openalex.org/W2038218988'], 'abstract_inverted_index': {'The': [0], 'presence': [1], 'of': [2, 4, 11, 18, 24, 30, 45, 64, 76, 104, 121, 138, 153, 164, 181, 186, 214, 217], 'tangles': [3], 'abnormally': [5], 'phosphorylated': [6], 'tau': [7, 51, 106, 143, 189], 'is': [8], 'a': [9, 42, 98, 110], 'characteristic': [10], "Alzheimer's": [12], 'disease': [13], '(AD),': [14], 'and': [15, 53, 79, 144, 178, 191, 220, 226], 'the': [16, 22, 28, 46, 102, 136, 184], 'loss': [17], 'synapses': [19], 'correlates': [20], 'with': [21, 66, 94, 123, 197], 'degree': [23], 'dementia.': [25], 'In': [26], 'addition,': [27], 'overexpression': [29], 'interleukin-1': [31], '(IL-1)': [32], 'has': [33], 'been': [34], 'implicated': [35], 'in': [36, 39, 50, 58, 92, 101, 112, 176, 209, 223], 'tangle': [37], 'formation': [38], 'AD.': [40], 'As': [41], 'direct': [43], 'test': [44], 'requirement': [47], 'for': [48], 'IL-1': [49, 56, 126], 'phosphorylation': [52, 103, 175, 190], 'synaptophysin': [54, 113, 192], 'expression,': [55], 'actions': [57], 'neuron-microglia': [59], 'cocultures': [60], 'were': [61, 90, 117], 'manipulated.': [62], 'Activation': [63], 'microglia': [65, 89, 140, 172, 203], 'secreted': [67], 'beta-amyloid': [68], 'precursor': [69], 'protein': [70, 167], 'or': [71], 'lipopolysaccharide': [72], 'elevated': [73], 'their': [74, 212], 'expression': [75], 'IL-1alpha,': [77], 'IL-1beta,': [78], 'tumor': [80], 'necrosis': [81], 'factor': [82], 'alpha': [83], '(TNFalpha)': [84], 'mRNA.': [85], 'When': [86], 'such': [87], 'activated': [88, 139, 171, 202], 'placed': [91], 'coculture': [93], 'primary': [95], 'neocortical': [96], 'neurons,': [97, 177], 'significant': [99], 'increase': [100], 'neuronal': [105, 142, 218, 224], 'was': [107, 149], 'accompanied': [108], 'by': [109, 119, 162], 'decline': [111], 'levels.': [114, 193], 'Similar': [115], 'effects': [116, 152], 'evoked': [118], 'treatment': [120], 'neurons': [122, 157], 'recombinant': [124], 'IL-1beta.': [125], 'receptor': [127], 'antagonist': [128], '(IL-1ra)': [129], 'as': [130, 132], 'well': [131], 'anti-IL-1beta': [133], 'antibody': [134, 148], 'attenuated': [135], 'influence': [137, 185], 'on': [141, 156, 188], 'synaptophysin,': [145], 'but': [146], 'anti-TNFalpha': [147], 'ineffective.': [150], 'Some': [151], 'microglial': [154], 'activation': [155, 163, 216], 'appear': [158], 'to': [159, 206], 'be': [160], 'mediated': [161], 'p38': [165], 'mitogen-activated': [166], 'kinase': [168], '(p38-MAPK),': [169], 'because': [170], 'stimulated': [173], 'p38-MAPK': [174, 182], 'an': [179], 'inhibitor': [180], 'reversed': [183], 'IL-1beta': [187], 'Our': [194], 'results,': [195], 'together': [196], 'previous': [198], 'observations,': [199], 'suggest': [200], 'that': [201], 'may': [204], 'contribute': [205], 'neurofibrillary': [207], 'pathology': [208], 'AD': [210], 'through': [211], 'production': [213], 'IL-1,': [215], 'p38-MAPK,': [219], 'resultant': [221], 'changes': [222], 'cytoskeletal': [225], 'synaptic': [227], 'elements.': [228]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2096158347', 'counts_by_year': [{'year': 2024, 'cited_by_count': 18}, {'year': 2023, 'cited_by_count': 28}, {'year': 2022, 'cited_by_count': 26}, {'year': 2021, 'cited_by_count': 33}, {'year': 2020, 'cited_by_count': 29}, {'year': 2019, 'cited_by_count': 28}, {'year': 2018, 'cited_by_count': 29}, {'year': 2017, 'cited_by_count': 28}, {'year': 2016, 'cited_by_count': 20}, {'year': 2015, 'cited_by_count': 28}, {'year': 2014, 'cited_by_count': 34}, {'year': 2013, 'cited_by_count': 28}, {'year': 2012, 'cited_by_count': 29}], 'updated_date': '2024-12-23T08:47:06.782405', 'created_date': '2016-06-24'}