Pravastatin Inhibits the Rho/CCN2/Extracellular Matrix Cascade in Human Fibrosis Explants and Improves Radiation-Induced Intestinal Fibrosis in Rats

Name: Work Video:
Duration: 3 min 30 s
Valérie Haydont; C. Bourgier; Marc Pocard; Antoine Lusinchi; Jocelyne Aigueperse; Denis Mathé; Jean Bourhis; Marie‐Catherine Vozenin
{'id': 'https://openalex.org/W2095638808', 'doi': 'https://doi.org/10.1158/1078-0432.ccr-07-0625', 'title': 'Pravastatin Inhibits the Rho/CCN2/Extracellular Matrix Cascade in Human Fibrosis Explants and Improves Radiation-Induced Intestinal Fibrosis in Rats', 'display_name': 'Pravastatin Inhibits the Rho/CCN2/Extracellular Matrix Cascade in Human Fibrosis Explants and Improves Radiation-Induced Intestinal Fibrosis in Rats', 'publication_year': 2007, 'publication_date': '2007-09-15', 'ids': {'openalex': 'https://openalex.org/W2095638808', 'doi': 'https://doi.org/10.1158/1078-0432.ccr-07-0625', 'mag': '2095638808', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/17875761'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1158/1078-0432.ccr-07-0625', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S183149254', 'display_name': 'Clinical Cancer Research', 'issn_l': '1078-0432', 'issn': ['1078-0432', '1557-3265'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5063832853', 'display_name': 'Valérie Haydont', 'orcid': 'https://orcid.org/0000-0001-5126-2156'}, 'institutions': [{'id': 'https://openalex.org/I1293448361', 'display_name': 'Institut de Radioprotection et de Sûreté Nucléaire', 'ror': 'https://ror.org/01ha22c77', 'country_code': 'FR', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I1293448361']}, {'id': 'https://openalex.org/I2801843802', 'display_name': 'Institut Gustave Roussy', 'ror': 'https://ror.org/0321g0743', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I2801843802']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Valérie Haydont', 'raw_affiliation_strings': ['1UPRES EA 27-10 “Radiosensibilité des Tumeurs et Tissus Sains”, Institut de Radioprotection et de Sûreté Nucléaire/Institut Gustave Roussy,', '4Laboratoire de Radiopathologie, SRBE/DRPH, Institut de Radioprotection et de Sûreté Nucléaire,'], 'affiliations': [{'raw_affiliation_string': '1UPRES EA 27-10 “Radiosensibilité des Tumeurs et Tissus Sains”, Institut de Radioprotection et de Sûreté Nucléaire/Institut Gustave Roussy,', 'institution_ids': ['https://openalex.org/I1293448361', 'https://openalex.org/I2801843802']}, {'raw_affiliation_string': '4Laboratoire de Radiopathologie, SRBE/DRPH, Institut de Radioprotection et de Sûreté Nucléaire,', 'institution_ids': ['https://openalex.org/I1293448361']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5076536874', 'display_name': 'C. Bourgier', 'orcid': 'https://orcid.org/0000-0001-5675-9989'}, 'institutions': [{'id': 'https://openalex.org/I2801843802', 'display_name': 'Institut Gustave Roussy', 'ror': 'https://ror.org/0321g0743', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I2801843802']}, {'id': 'https://openalex.org/I1293448361', 'display_name': 'Institut de Radioprotection et de Sûreté Nucléaire', 'ror': 'https://ror.org/01ha22c77', 'country_code': 'FR', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I1293448361']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Céline Bourgier', 'raw_affiliation_strings': ['1UPRES EA 27-10 “Radiosensibilité des Tumeurs et Tissus Sains”, Institut de Radioprotection et de Sûreté Nucléaire/Institut Gustave Roussy,', '4Laboratoire de Radiopathologie, SRBE/DRPH, Institut de Radioprotection et de Sûreté Nucléaire,'], 'affiliations': [{'raw_affiliation_string': '1UPRES EA 27-10 “Radiosensibilité des Tumeurs et Tissus Sains”, Institut de Radioprotection et de Sûreté Nucléaire/Institut Gustave Roussy,', 'institution_ids': ['https://openalex.org/I2801843802', 'https://openalex.org/I1293448361']}, {'raw_affiliation_string': '4Laboratoire de Radiopathologie, SRBE/DRPH, Institut de Radioprotection et de Sûreté Nucléaire,', 'institution_ids': ['https://openalex.org/I1293448361']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5090614409', 'display_name': 'Marc Pocard', 'orcid': 'https://orcid.org/0000-0002-4793-0008'}, 'institutions': [{'id': 'https://openalex.org/I4210155148', 'display_name': 'Générale de Santé', 'ror': 'https://ror.org/05evp6y14', 'country_code': 'FR', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210155148']}, {'id': 'https://openalex.org/I4210119095', 'display_name': 'Hôpital Lariboisière', 'ror': 'https://ror.org/02mqtne57', 'country_code': 'FR', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210097159', 'https://openalex.org/I4210119095']}, {'id': 'https://openalex.org/I2801843802', 'display_name': 'Institut Gustave Roussy', 'ror': 'https://ror.org/0321g0743', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I2801843802']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Marc Pocard', 'raw_affiliation_strings': ['2Département de Chirurgie Générale and', '6Département Médico-Chirurgical de Pathologie Digestive, Hôpital Lariboisière, Paris, France', 'Institut Gustave Roussy'], 'affiliations': [{'raw_affiliation_string': '2Département de Chirurgie Générale and', 'institution_ids': ['https://openalex.org/I4210155148']}, {'raw_affiliation_string': '6Département Médico-Chirurgical de Pathologie Digestive, Hôpital Lariboisière, Paris, France', 'institution_ids': ['https://openalex.org/I4210119095']}, {'raw_affiliation_string': 'Institut Gustave Roussy', 'institution_ids': ['https://openalex.org/I2801843802']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5113525455', 'display_name': 'Antoine Lusinchi', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I2801843802', 'display_name': 'Institut Gustave Roussy', 'ror': 'https://ror.org/0321g0743', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I2801843802']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Antoine Lusinchi', 'raw_affiliation_strings': ['3Département de Radiothérapie, Institut Gustave Roussy, Villejuif, France;'], 'affiliations': [{'raw_affiliation_string': '3Département de Radiothérapie, Institut Gustave Roussy, Villejuif, France;', 'institution_ids': ['https://openalex.org/I2801843802']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5033297146', 'display_name': 'Jocelyne Aigueperse', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1293448361', 'display_name': 'Institut de Radioprotection et de Sûreté Nucléaire', 'ror': 'https://ror.org/01ha22c77', 'country_code': 'FR', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I1293448361']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Jocelyne Aigueperse', 'raw_affiliation_strings': ['5DRPH, Institut de Radioprotection et de Sûreté Nucléaire, Fontenay-aux-Roses, France; and'], 'affiliations': [{'raw_affiliation_string': '5DRPH, Institut de Radioprotection et de Sûreté Nucléaire, Fontenay-aux-Roses, France; and', 'institution_ids': ['https://openalex.org/I1293448361']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5112865382', 'display_name': 'Denis Mathé', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1293448361', 'display_name': 'Institut de Radioprotection et de Sûreté Nucléaire', 'ror': 'https://ror.org/01ha22c77', 'country_code': 'FR', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I1293448361']}, {'id': 'https://openalex.org/I2801843802', 'display_name': 'Institut Gustave Roussy', 'ror': 'https://ror.org/0321g0743', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I2801843802']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Denis Mathé', 'raw_affiliation_strings': ['1UPRES EA 27-10 “Radiosensibilité des Tumeurs et Tissus Sains”, Institut de Radioprotection et de Sûreté Nucléaire/Institut Gustave Roussy,'], 'affiliations': [{'raw_affiliation_string': '1UPRES EA 27-10 “Radiosensibilité des Tumeurs et Tissus Sains”, Institut de Radioprotection et de Sûreté Nucléaire/Institut Gustave Roussy,', 'institution_ids': ['https://openalex.org/I1293448361', 'https://openalex.org/I2801843802']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5079405457', 'display_name': 'Jean Bourhis', 'orcid': 'https://orcid.org/0000-0001-5162-1171'}, 'institutions': [{'id': 'https://openalex.org/I1293448361', 'display_name': 'Institut de Radioprotection et de Sûreté Nucléaire', 'ror': 'https://ror.org/01ha22c77', 'country_code': 'FR', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I1293448361']}, {'id': 'https://openalex.org/I2801843802', 'display_name': 'Institut Gustave Roussy', 'ror': 'https://ror.org/0321g0743', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I2801843802']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Jean Bourhis', 'raw_affiliation_strings': ['1UPRES EA 27-10 “Radiosensibilité des Tumeurs et Tissus Sains”, Institut de Radioprotection et de Sûreté Nucléaire/Institut Gustave Roussy,', '3Département de Radiothérapie, Institut Gustave Roussy, Villejuif, France;'], 'affiliations': [{'raw_affiliation_string': '1UPRES EA 27-10 “Radiosensibilité des Tumeurs et Tissus Sains”, Institut de Radioprotection et de Sûreté Nucléaire/Institut Gustave Roussy,', 'institution_ids': ['https://openalex.org/I1293448361', 'https://openalex.org/I2801843802']}, {'raw_affiliation_string': '3Département de Radiothérapie, Institut Gustave Roussy, Villejuif, France;', 'institution_ids': ['https://openalex.org/I2801843802']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5006971681', 'display_name': 'Marie‐Catherine Vozenin', 'orcid': 'https://orcid.org/0000-0002-2109-8073'}, 'institutions': [{'id': 'https://openalex.org/I1293448361', 'display_name': 'Institut de Radioprotection et de Sûreté Nucléaire', 'ror': 'https://ror.org/01ha22c77', 'country_code': 'FR', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I1293448361']}, {'id': 'https://openalex.org/I2801843802', 'display_name': 'Institut Gustave Roussy', 'ror': 'https://ror.org/0321g0743', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I2801843802']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Marie-Catherine Vozenin-Brotons', 'raw_affiliation_strings': ['1UPRES EA 27-10 “Radiosensibilité des Tumeurs et Tissus Sains”, Institut de Radioprotection et de Sûreté Nucléaire/Institut Gustave Roussy,', '4Laboratoire de Radiopathologie, SRBE/DRPH, Institut de Radioprotection et de Sûreté Nucléaire,'], 'affiliations': [{'raw_affiliation_string': '1UPRES EA 27-10 “Radiosensibilité des Tumeurs et Tissus Sains”, Institut de Radioprotection et de Sûreté Nucléaire/Institut Gustave Roussy,', 'institution_ids': ['https://openalex.org/I1293448361', 'https://openalex.org/I2801843802']}, {'raw_affiliation_string': '4Laboratoire de Radiopathologie, SRBE/DRPH, Institut de Radioprotection et de Sûreté Nucléaire,', 'institution_ids': ['https://openalex.org/I1293448361']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 4, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 5.495, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 131, 'citation_normalized_percentile': {'value': 0.999934, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 97, 'max': 98}, 'biblio': {'volume': '13', 'issue': '18', 'first_page': '5331', 'last_page': '5340'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11359', 'display_name': 'Effects of Radiation Exposure', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2741', 'display_name': 'Radiology, Nuclear Medicine and Imaging'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11359', 'display_name': 'Effects of Radiation Exposure', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2741', 'display_name': 'Radiology, Nuclear Medicine and Imaging'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12108', 'display_name': 'Management of metastatic bone disease', 'score': 0.9982, 'subfield': {'id': 'https://openalex.org/subfields/2746', 'display_name': 'Surgery'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10543', 'display_name': 'Prostate Cancer Treatment and Research', 'score': 0.972, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/ex-vivo', 'display_name': 'Ex vivo', 'score': 0.5831521}], 'concepts': [{'id': 'https://openalex.org/C2780559512', 'wikidata': 'https://www.wikidata.org/wiki/Q605709', 'display_name': 'Fibrosis', 'level': 2, 'score': 0.65818906}, {'id': 'https://openalex.org/C2779519902', 'wikidata': 'https://www.wikidata.org/wiki/Q1240093', 'display_name': 'Pravastatin', 'level': 3, 'score': 0.6569886}, {'id': 'https://openalex.org/C26291073', 'wikidata': 'https://www.wikidata.org/wiki/Q310484', 'display_name': 'Ex vivo', 'level': 3, 'score': 0.5831521}, {'id': 'https://openalex.org/C86492073', 'wikidata': 'https://www.wikidata.org/wiki/Q413766', 'display_name': 'Fibronectin', 'level': 3, 'score': 0.5792284}, {'id': 'https://openalex.org/C189165786', 'wikidata': 'https://www.wikidata.org/wiki/Q193825', 'display_name': 'Extracellular matrix', 'level': 2, 'score': 0.5192887}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.49088842}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.46081585}, {'id': 'https://openalex.org/C2778426112', 'wikidata': 'https://www.wikidata.org/wiki/Q3055380', 'display_name': 'Enteropathy', 'level': 3, 'score': 0.4466847}, {'id': 'https://openalex.org/C207001950', 'wikidata': 'https://www.wikidata.org/wiki/Q141124', 'display_name': 'In vivo', 'level': 2, 'score': 0.40871483}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.38040218}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.34075874}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.32399994}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.2896489}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.25745445}, {'id': 'https://openalex.org/C150903083', 'wikidata': 'https://www.wikidata.org/wiki/Q7108', 'display_name': 'Biotechnology', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C2779134260', 'wikidata': 'https://www.wikidata.org/wiki/Q12136', 'display_name': 'Disease', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C2778163477', 'wikidata': 'https://www.wikidata.org/wiki/Q43656', 'display_name': 'Cholesterol', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D019161', 'descriptor_name': 'Hydroxymethylglutaryl-CoA Reductase Inhibitors', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D017874', 'descriptor_name': 'Immediate-Early Proteins', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': True}, {'descriptor_ui': 'D007410', 'descriptor_name': 'Intestinal Diseases', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D017035', 'descriptor_name': 'Pravastatin', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D011832', 'descriptor_name': 'Radiation Injuries', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D020741', 'descriptor_name': 'rho GTP-Binding Proteins', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': True}, {'descriptor_ui': 'D054460', 'descriptor_name': 'rho-Associated Kinases', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D055513', 'descriptor_name': 'Connective Tissue Growth Factor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005109', 'descriptor_name': 'Extracellular Matrix', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D005109', 'descriptor_name': 'Extracellular Matrix', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005355', 'descriptor_name': 'Fibrosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019161', 'descriptor_name': 'Hydroxymethylglutaryl-CoA Reductase Inhibitors', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D019161', 'descriptor_name': 'Hydroxymethylglutaryl-CoA Reductase Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017874', 'descriptor_name': 'Immediate-Early Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D036341', 'descriptor_name': 'Intercellular Signaling Peptides and Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007410', 'descriptor_name': 'Intestinal Diseases', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D007410', 'descriptor_name': 'Intestinal Diseases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D007410', 'descriptor_name': 'Intestinal Diseases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007422', 'descriptor_name': 'Intestines', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D007422', 'descriptor_name': 'Intestines', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D007422', 'descriptor_name': 'Intestines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017035', 'descriptor_name': 'Pravastatin', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D017035', 'descriptor_name': 'Pravastatin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011832', 'descriptor_name': 'Radiation Injuries', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D011832', 'descriptor_name': 'Radiation Injuries', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011832', 'descriptor_name': 'Radiation Injuries', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D051381', 'descriptor_name': 'Rats', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017208', 'descriptor_name': 'Rats, Wistar', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020741', 'descriptor_name': 'rho GTP-Binding Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D054460', 'descriptor_name': 'rho-Associated Kinases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1158/1078-0432.ccr-07-0625', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S183149254', 'display_name': 'Clinical Cancer Research', 'issn_l': '1078-0432', 'issn': ['1078-0432', '1557-3265'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://hal.archives-ouvertes.fr/hal-03015590', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306402512', 'display_name': 'HAL (Le Centre pour la Communication Scientifique Directe)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1294671590', 'host_organization_name': 'Centre National de la Recherche Scientifique', 'host_organization_lineage': ['https://openalex.org/I1294671590'], 'host_organization_lineage_names': ['Centre National de la Recherche Scientifique'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://hal.science/hal-03015590', 'pdf_url': None, 'source': None, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/17875761', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'score': 0.5, 'id': 'https://metadata.un.org/sdg/6', 'display_name': 'Clean water and sanitation'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 43, 'referenced_works': ['https://openalex.org/W1963780536', 'https://openalex.org/W1963829759', 'https://openalex.org/W1967637508', 'https://openalex.org/W1985643757', 'https://openalex.org/W1992540727', 'https://openalex.org/W1998324537', 'https://openalex.org/W1998538870', 'https://openalex.org/W2004456664', 'https://openalex.org/W2015886334', 'https://openalex.org/W2020122922', 'https://openalex.org/W2020391654', 'https://openalex.org/W2020894250', 'https://openalex.org/W2025566748', 'https://openalex.org/W2027214733', 'https://openalex.org/W2035350682', 'https://openalex.org/W2035700687', 'https://openalex.org/W2039909868', 'https://openalex.org/W2044554552', 'https://openalex.org/W2056897769', 'https://openalex.org/W2059310347', 'https://openalex.org/W2061523453', 'https://openalex.org/W2072205478', 'https://openalex.org/W2072318687', 'https://openalex.org/W2077103009', 'https://openalex.org/W2077603983', 'https://openalex.org/W2084660313', 'https://openalex.org/W2110365702', 'https://openalex.org/W2112575569', 'https://openalex.org/W2120683054', 'https://openalex.org/W2128602373', 'https://openalex.org/W2135896142', 'https://openalex.org/W2138605058', 'https://openalex.org/W2139273336', 'https://openalex.org/W2146481308', 'https://openalex.org/W2148654700', 'https://openalex.org/W2149933426', 'https://openalex.org/W2150198473', 'https://openalex.org/W2150317326', 'https://openalex.org/W2163737997', 'https://openalex.org/W2168474670', 'https://openalex.org/W2170186125', 'https://openalex.org/W2174608167', 'https://openalex.org/W611752577'], 'related_works': ['https://openalex.org/W2489907708', 'https://openalex.org/W2415579317', 'https://openalex.org/W2413789852', 'https://openalex.org/W2411167527', 'https://openalex.org/W2072852721', 'https://openalex.org/W2062264045', 'https://openalex.org/W2061840290', 'https://openalex.org/W1996614826', 'https://openalex.org/W1982977391', 'https://openalex.org/W1971253495'], 'abstract_inverted_index': {'Abstract': [0], 'Purposes:': [1], 'Intestinal': [2], 'complications': [3], 'after': [4, 83], 'radiotherapy': [5], 'are': [6], 'caused': [7], 'by': [8], 'transmural': [9], 'fibrosis': [10, 21, 81, 132, 230], 'and': [11, 25, 52, 63, 71, 94, 101, 168, 175, 188, 221, 236, 243], 'impair': [12], 'the': [13, 38, 49, 112, 116, 142, 196, 248], 'quality': [14], 'of': [15, 17, 40, 89, 115, 119, 129, 184, 199, 219], 'life': [16], 'cancer': [18], 'survivors.': [19], 'Radiation': [20], 'was': [22, 32, 121], 'considered': [23], 'permanent': [24], 'irreversible,': [26], 'but': [27], 'recently,': [28], 'its': [29], 'dynamic': [30], 'nature': [31], 'shown,': [33], 'providing': [34], 'new': [35, 45], 'opportunities': [36], 'for': [37], 'development': [39], 'antifibrotic': [41, 66, 117, 238], 'therapies.': [42], 'Among': [43], 'these': [44], 'targets,': [46], 'we': [47], 'identified': [48], 'Rho/ROCK': [50], 'pathway': [51, 61], 'thought': [53], 'to': [54], 'investigate': [55], 'whether': [56], 'pravastatin': [57, 120, 140, 154, 194, 204, 232], 'treatment': [58], 'inhibits': [59, 156], 'Rho': [60, 70, 157], 'activation': [62], 'elicits': [64, 165], 'an': [65, 234], 'action.': [67], 'Experimental': [68], 'Design:': [69], 'ROCK': [72, 166], 'activities': [73], 'were': [74, 97], 'monitored': [75], 'in': [76, 102, 123, 125, 141, 159, 172, 209, 240], 'human': [77, 150, 173], 'explants': [78, 151, 174], 'presenting': [79], 'radiation': [80, 109, 131, 181, 207], 'remodeling': [82], 'incubation': [84], 'with': [85, 137, 149, 216, 231], 'pravastatin.': [86], 'Subsequent': [87], 'modulation': [88], 'CCN2,': [90], 'type': [91, 185], 'I': [92, 186], 'collagen,': [93], 'fibronectin': [95, 189], 'expression': [96], 'assessed': [98], 'ex': [99], 'vivo': [100, 124], 'intestinal': [103], 'smooth': [104, 176], 'muscle': [105, 177], 'cells': [106, 178], 'derived': [107], 'from': [108, 180], 'enteropathy.': [110, 182], 'Then,': [111], 'therapeutic': [113], 'relevance': [114], 'action': [118], 'explored': [122], 'a': [126], 'rat': [127], 'model': [128], 'chronic': [130], '(19': [133], 'Gy': [134], 'X-rays)': [135], 'treated': [136], '30': [138], 'mg/kg/d': [139], 'drinking': [143], 'water.': [144], 'Results:': [145], 'The': [146], 'results': [147], 'obtained': [148], 'show': [152], 'that': [153, 193], 'specifically': [155], 'activity': [158], 'submucosal': [160], 'mesenchymal': [161, 200], 'cells.': [162, 201], 'Pravastatin': [163], 'also': [164], 'inhibition,': [167], 'subsequent': [169, 222], 'CCN2': [170, 220], 'production': [171], 'isolated': [179], 'Inhibition': [183], 'collagen': [187], 'does': [190], 'occur,': [191], 'showing': [192], 'modulates': [195], 'secretory': [197], 'phenotype': [198], 'Lastly,': [202], 'curative': [203], 'administration': [205], 'improves': [206], 'enteropathy': [208], 'rats.': [210], 'This': [211], 'structural': [212], 'improvement': [213], 'is': [214, 233, 244], 'associated': [215], 'decreased': [217, 223], 'deposition': [218], 'extracellular': [224], 'matrix': [225], 'deposition.': [226], 'Conclusion:': [227], 'Targeting': [228], 'established': [229], 'efficient': [235], 'safe': [237], 'strategy': [239], 'radiation-induced': [241], 'enteropathy,': [242], 'easily': [245], 'transferable': [246], 'into': [247], 'clinic.': [249]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2095638808', 'counts_by_year': [{'year': 2024, 'cited_by_count': 4}, {'year': 2023, 'cited_by_count': 8}, {'year': 2022, 'cited_by_count': 8}, {'year': 2021, 'cited_by_count': 5}, {'year': 2020, 'cited_by_count': 7}, {'year': 2019, 'cited_by_count': 4}, {'year': 2018, 'cited_by_count': 7}, {'year': 2017, 'cited_by_count': 9}, {'year': 2016, 'cited_by_count': 9}, {'year': 2015, 'cited_by_count': 5}, {'year': 2014, 'cited_by_count': 8}, {'year': 2013, 'cited_by_count': 9}, {'year': 2012, 'cited_by_count': 12}], 'updated_date': '2025-01-10T00:27:41.406094', 'created_date': '2016-06-24'}
Publication Information

Basic Information

Access and Citation

AI Researcher Chatbot

Primary Location

Authors

Topics

Keywords

Related Works
