Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2095568461', 'doi': 'https://doi.org/10.1016/j.febslet.2007.01.024', 'title': 'Mutational analysis revealed that conservation of hepatitis B virus reverse transcriptase residue 306 (rtP306) is crucial for encapsidation of pregenomic RNA', 'display_name': 'Mutational analysis revealed that conservation of hepatitis B virus reverse transcriptase residue 306 (rtP306) is crucial for encapsidation of pregenomic RNA', 'publication_year': 2007, 'publication_date': '2007-01-18', 'ids': {'openalex': 'https://openalex.org/W2095568461', 'doi': 'https://doi.org/10.1016/j.febslet.2007.01.024', 'mag': '2095568461', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/17254572'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.febslet.2007.01.024', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S104830714', 'display_name': 'FEBS Letters', 'issn_l': '0014-5793', 'issn': ['0014-5793', '1873-3468'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5100641863', 'display_name': 'Yongxiang Wang', 'orcid': 'https://orcid.org/0000-0002-8832-7301'}, 'institutions': [{'id': 'https://openalex.org/I133868755', 'display_name': 'Shanghai Medical College of Fudan University', 'ror': 'https://ror.org/01zntxs11', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I133868755', 'https://openalex.org/I24943067']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yong-Xiang Wang', 'raw_affiliation_strings': ['Key Laboratory of Medical Molecular Virology, Institute of Medical Microbiology, Shanghai Medical College, Fudan University, 138 Yi Xue Yuan Road, Shanghai 200032, PR China.'], 'affiliations': [{'raw_affiliation_string': 'Key Laboratory of Medical Molecular Virology, Institute of Medical Microbiology, Shanghai Medical College, Fudan University, 138 Yi Xue Yuan Road, Shanghai 200032, PR China.', 'institution_ids': ['https://openalex.org/I133868755']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5051465812', 'display_name': 'Xiang Xu', 'orcid': 'https://orcid.org/0000-0001-8293-3776'}, 'institutions': [{'id': 'https://openalex.org/I19820366', 'display_name': 'Chinese Academy of Sciences', 'ror': 'https://ror.org/034t30j35', 'country_code': 'CN', 'type': 'government', 'lineage': ['https://openalex.org/I19820366']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Xiang Xu', 'raw_affiliation_strings': ['Key Laboratory of Proteomics, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, PR China.'], 'affiliations': [{'raw_affiliation_string': 'Key Laboratory of Proteomics, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, PR China.', 'institution_ids': ['https://openalex.org/I19820366']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5024637740', 'display_name': 'Cheng Luo', 'orcid': 'https://orcid.org/0000-0003-3864-8382'}, 'institutions': [{'id': 'https://openalex.org/I4210106477', 'display_name': 'Shanghai Institutes for Biological Sciences', 'ror': 'https://ror.org/011rf9d86', 'country_code': 'CN', 'type': 'facility', 'lineage': ['https://openalex.org/I19820366', 'https://openalex.org/I4210106477']}, {'id': 'https://openalex.org/I4210112820', 'display_name': 'Shanghai Institute of Materia Medica', 'ror': 'https://ror.org/022syn853', 'country_code': 'CN', 'type': 'facility', 'lineage': ['https://openalex.org/I19820366', 'https://openalex.org/I4210112820']}, {'id': 'https://openalex.org/I19820366', 'display_name': 'Chinese Academy of Sciences', 'ror': 'https://ror.org/034t30j35', 'country_code': 'CN', 'type': 'government', 'lineage': ['https://openalex.org/I19820366']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Cheng Luo', 'raw_affiliation_strings': ['Center for Drug Discovery and Design, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 201203, PR China'], 'affiliations': [{'raw_affiliation_string': 'Center for Drug Discovery and Design, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 201203, PR China', 'institution_ids': ['https://openalex.org/I4210106477', 'https://openalex.org/I4210112820', 'https://openalex.org/I19820366']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5111913652', 'display_name': 'Zhang‐Mei Ma', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I133868755', 'display_name': 'Shanghai Medical College of Fudan University', 'ror': 'https://ror.org/01zntxs11', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I133868755', 'https://openalex.org/I24943067']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Zhang-Mei Ma', 'raw_affiliation_strings': ['Key Laboratory of Medical Molecular Virology, Institute of Medical Microbiology, Shanghai Medical College, Fudan University, 138 Yi Xue Yuan Road, Shanghai 200032, PR China.'], 'affiliations': [{'raw_affiliation_string': 'Key Laboratory of Medical Molecular Virology, Institute of Medical Microbiology, Shanghai Medical College, Fudan University, 138 Yi Xue Yuan Road, Shanghai 200032, PR China.', 'institution_ids': ['https://openalex.org/I133868755']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5001392142', 'display_name': 'Hualiang Jiang', 'orcid': 'https://orcid.org/0000-0003-0656-6315'}, 'institutions': [{'id': 'https://openalex.org/I4210112820', 'display_name': 'Shanghai Institute of Materia Medica', 'ror': 'https://ror.org/022syn853', 'country_code': 'CN', 'type': 'facility', 'lineage': ['https://openalex.org/I19820366', 'https://openalex.org/I4210112820']}, {'id': 'https://openalex.org/I19820366', 'display_name': 'Chinese Academy of Sciences', 'ror': 'https://ror.org/034t30j35', 'country_code': 'CN', 'type': 'government', 'lineage': ['https://openalex.org/I19820366']}, {'id': 'https://openalex.org/I4210106477', 'display_name': 'Shanghai Institutes for Biological Sciences', 'ror': 'https://ror.org/011rf9d86', 'country_code': 'CN', 'type': 'facility', 'lineage': ['https://openalex.org/I19820366', 'https://openalex.org/I4210106477']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Hua-Liang Jiang', 'raw_affiliation_strings': ['Center for Drug Discovery and Design, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 201203, PR China'], 'affiliations': [{'raw_affiliation_string': 'Center for Drug Discovery and Design, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 201203, PR China', 'institution_ids': ['https://openalex.org/I4210112820', 'https://openalex.org/I19820366', 'https://openalex.org/I4210106477']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5112512641', 'display_name': 'Jianping Ding', 'orcid': 'https://orcid.org/0000-0001-7029-7346'}, 'institutions': [{'id': 'https://openalex.org/I19820366', 'display_name': 'Chinese Academy of Sciences', 'ror': 'https://ror.org/034t30j35', 'country_code': 'CN', 'type': 'government', 'lineage': ['https://openalex.org/I19820366']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Jian-Ping Ding', 'raw_affiliation_strings': ['Key Laboratory of Proteomics, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, PR China.'], 'affiliations': [{'raw_affiliation_string': 'Key Laboratory of Proteomics, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, PR China.', 'institution_ids': ['https://openalex.org/I19820366']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5100530852', 'display_name': 'Yu‐Mei Wen', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I133868755', 'display_name': 'Shanghai Medical College of Fudan University', 'ror': 'https://ror.org/01zntxs11', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I133868755', 'https://openalex.org/I24943067']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yu-Mei Wen', 'raw_affiliation_strings': ['Key Laboratory of Medical Molecular Virology, Institute of Medical Microbiology, Shanghai Medical College, Fudan University, 138 Yi Xue Yuan Road, Shanghai 200032, PR China.'], 'affiliations': [{'raw_affiliation_string': 'Key Laboratory of Medical Molecular Virology, Institute of Medical Microbiology, Shanghai Medical College, Fudan University, 138 Yi Xue Yuan Road, Shanghai 200032, PR China.', 'institution_ids': ['https://openalex.org/I133868755']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 4, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 3610, 'currency': 'USD', 'value_usd': 3610, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 1.239, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 15, 'citation_normalized_percentile': {'value': 0.778212, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 86, 'max': 87}, 'biblio': {'volume': '581', 'issue': '3', 'first_page': '558', 'last_page': '564'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10340', 'display_name': 'Hepatitis B Virus Studies', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10340', 'display_name': 'Hepatitis B Virus Studies', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10151', 'display_name': 'Hepatitis C virus research', 'score': 0.9986, 'subfield': {'id': 'https://openalex.org/subfields/2721', 'display_name': 'Hepatology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10351', 'display_name': 'Liver Disease Diagnosis and Treatment', 'score': 0.9946, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/reverse-genetics', 'display_name': 'Reverse Genetics', 'score': 0.4347575}], 'concepts': [{'id': 'https://openalex.org/C156719811', 'wikidata': 'https://www.wikidata.org/wiki/Q28774', 'display_name': 'Reverse transcriptase', 'level': 4, 'score': 0.810233}, {'id': 'https://openalex.org/C143065580', 'wikidata': 'https://www.wikidata.org/wiki/Q3285695', 'display_name': 'Mutant', 'level': 3, 'score': 0.58590543}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.5486723}, {'id': 'https://openalex.org/C140704245', 'wikidata': 'https://www.wikidata.org/wiki/Q3933202', 'display_name': 'Viral replication', 'level': 3, 'score': 0.54460084}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.5361514}, {'id': 'https://openalex.org/C159047783', 'wikidata': 'https://www.wikidata.org/wiki/Q7215', 'display_name': 'Virology', 'level': 1, 'score': 0.5132735}, {'id': 'https://openalex.org/C2777666129', 'wikidata': 'https://www.wikidata.org/wiki/Q3503198', 'display_name': 'Duck hepatitis B virus', 'level': 5, 'score': 0.4969714}, {'id': 'https://openalex.org/C2780593183', 'wikidata': 'https://www.wikidata.org/wiki/Q6844', 'display_name': 'Hepatitis B virus', 'level': 3, 'score': 0.4937993}, {'id': 'https://openalex.org/C67705224', 'wikidata': 'https://www.wikidata.org/wiki/Q11053', 'display_name': 'RNA', 'level': 3, 'score': 0.46719193}, {'id': 'https://openalex.org/C25365240', 'wikidata': 'https://www.wikidata.org/wiki/Q1897151', 'display_name': 'Reverse genetics', 'level': 4, 'score': 0.4347575}, {'id': 'https://openalex.org/C202878990', 'wikidata': 'https://www.wikidata.org/wiki/Q830465', 'display_name': 'Capsid', 'level': 3, 'score': 0.4173703}, {'id': 'https://openalex.org/C2522874641', 'wikidata': 'https://www.wikidata.org/wiki/Q808', 'display_name': 'Virus', 'level': 2, 'score': 0.38432688}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.3254795}, {'id': 'https://openalex.org/C2780617729', 'wikidata': 'https://www.wikidata.org/wiki/Q1356878', 'display_name': 'Hepadnaviridae', 'level': 4, 'score': 0.23368913}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.20910212}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.17720726}], 'mesh': [{'descriptor_ui': 'D006515', 'descriptor_name': 'Hepatitis B virus', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D006515', 'descriptor_name': 'Hepatitis B virus', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': True}, {'descriptor_ui': 'D012367', 'descriptor_name': 'RNA, Viral', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D012194', 'descriptor_name': 'RNA-Directed DNA Polymerase', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D012194', 'descriptor_name': 'RNA-Directed DNA Polymerase', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D019943', 'descriptor_name': 'Amino Acid Substitution', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001483', 'descriptor_name': 'Base Sequence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002460', 'descriptor_name': 'Cell Line', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017124', 'descriptor_name': 'Conserved Sequence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004279', 'descriptor_name': 'DNA, Viral', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004279', 'descriptor_name': 'DNA, Viral', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D005816', 'descriptor_name': 'Genetic Complementation Test', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006515', 'descriptor_name': 'Hepatitis B virus', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D006515', 'descriptor_name': 'Hepatitis B virus', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016297', 'descriptor_name': 'Mutagenesis, Site-Directed', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011392', 'descriptor_name': 'Proline', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D011392', 'descriptor_name': 'Proline', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012367', 'descriptor_name': 'RNA, Viral', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D012367', 'descriptor_name': 'RNA, Viral', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012194', 'descriptor_name': 'RNA-Directed DNA Polymerase', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D012194', 'descriptor_name': 'RNA-Directed DNA Polymerase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011994', 'descriptor_name': 'Recombinant Proteins', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D011994', 'descriptor_name': 'Recombinant Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D011994', 'descriptor_name': 'Recombinant Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D011994', 'descriptor_name': 'Recombinant Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014162', 'descriptor_name': 'Transfection', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019065', 'descriptor_name': 'Virus Assembly', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014779', 'descriptor_name': 'Virus Replication', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.febslet.2007.01.024', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S104830714', 'display_name': 'FEBS Letters', 'issn_l': '0014-5793', 'issn': ['0014-5793', '1873-3468'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/17254572', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/15', 'display_name': 'Life on land', 'score': 0.74}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 38, 'referenced_works': ['https://openalex.org/W1502882236', 'https://openalex.org/W1511455589', 'https://openalex.org/W1582353365', 'https://openalex.org/W1585930597', 'https://openalex.org/W1594251072', 'https://openalex.org/W1603287226', 'https://openalex.org/W1769252171', 'https://openalex.org/W1805434135', 'https://openalex.org/W1853569310', 'https://openalex.org/W1931068024', 'https://openalex.org/W1967159039', 'https://openalex.org/W1975288350', 'https://openalex.org/W1979730660', 'https://openalex.org/W2032552720', 'https://openalex.org/W2044951291', 'https://openalex.org/W2051100798', 'https://openalex.org/W2061239746', 'https://openalex.org/W2069336380', 'https://openalex.org/W2095427717', 'https://openalex.org/W2096808350', 'https://openalex.org/W2104475038', 'https://openalex.org/W2105546213', 'https://openalex.org/W2107057287', 'https://openalex.org/W2111028462', 'https://openalex.org/W2116527376', 'https://openalex.org/W2116606690', 'https://openalex.org/W2120085322', 'https://openalex.org/W2125810584', 'https://openalex.org/W2125840593', 'https://openalex.org/W2127802632', 'https://openalex.org/W2136875552', 'https://openalex.org/W2140206005', 'https://openalex.org/W2141558821', 'https://openalex.org/W2144476088', 'https://openalex.org/W2152203386', 'https://openalex.org/W2164454350', 'https://openalex.org/W2291407818', 'https://openalex.org/W2804007336'], 'related_works': ['https://openalex.org/W3097901346', 'https://openalex.org/W2412476639', 'https://openalex.org/W2337862536', 'https://openalex.org/W2330419387', 'https://openalex.org/W2143838453', 'https://openalex.org/W2098905737', 'https://openalex.org/W2081492015', 'https://openalex.org/W2072577521', 'https://openalex.org/W2000386400', 'https://openalex.org/W1895903094'], 'abstract_inverted_index': {'Hepatitis': [0], 'B': [1], 'virus': [2, 7], '(HBV)': [3], 'is': [4, 188], 'a': [5, 115], 'DNA': [6], 'which': [8, 148], 'replicates': [9], 'via': [10], 'reverse': [11, 19, 39], 'transcription.': [12], 'The': [13, 129], 'structure': [14], 'and': [15, 79, 84, 90, 107, 114], 'function': [16], 'of': [17, 48, 87, 104, 132, 154, 183, 193], 'the': [18, 49, 57, 88, 91, 105, 152, 178], 'transcriptase': [20, 40], 'play': [21], 'important': [22], 'roles': [23], 'in': [24, 37, 62, 120, 141, 168], 'HBV': [25, 38, 155], 'replication.': [26], 'We': [27], 'have': [28], 'previously': [29], 'reported': [30], 'that': [31, 181], 'when': [32], 'proline': [33, 184], 'at': [34, 71, 172, 185], 'residue': [35, 173, 187], '306': [36], 'was': [41, 100, 123, 166], 'substituted': [42, 67, 171], 'by': [43, 109, 137, 158], 'other': [44], 'amino': [45, 68], 'acids,': [46], 'most': [47], 'mutants': [50, 89, 106, 170], 'showed': [51], 'decreased': [52], 'replicative': [53, 63], 'competency.': [54], 'To': [55], 'explore': [56], 'mechanisms': [58], 'for': [59, 151, 177, 190], 'this': [60, 186], 'decrease': [61], 'competency,': [64], 'constructs': [65, 134], 'with': [66, 102], 'acid': [69], 'residues': [70], 'rtP306': [72], 'were': [73, 95, 135, 149], 'used': [74], 'to': [75], 'transfect': [76], 'Huh‐7': [77], 'cells,': [78, 147], 'replication': [80, 98], 'competencies,': [81], 'transcription': [82], 'levels': [83], 'encapsidation': [85, 130, 165, 192], 'efficiencies': [86], 'parental': [92], 'viral': [93], 'strain': [94], 'compared.': [96], 'Decreased': [97], 'competency': [99], 'found': [101, 167], 'many': [103], 'confirmed': [108], 'trans‐complementation': [110], 'between': [111, 125], 'each': [112], 'mutant': [113], 'replication‐defective': [116], 'replicon.': [117], 'No': [118], 'change': [119], 'transcriptional': [121], 'level': [122], 'detected': [124], 'all': [126], 'mutated': [127], 'constructs.': [128], 'competencies': [131], 'these': [133], 'studied': [136], 'assaying': [138], 'pregenomic': [139, 194], 'RNAs': [140], 'intracytoplamic': [142], 'core': [143, 156], 'particles': [144], 'from': [145], 'transfected': [146], 'normalized': [150], 'amount': [153], 'protein': [157], 'Western': [159], 'blotting': [160], 'using': [161], 'anti‐core': [162], 'antibodies.': [163], 'Impaired': [164], 'several': [169], '306,': [174], 'thereby': [175], 'demonstrating': [176], 'first': [179], 'time': [180], 'conservation': [182], 'crucial': [189], 'efficient': [191], 'RNA.': [195]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2095568461', 'counts_by_year': [{'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 1}, {'year': 2012, 'cited_by_count': 2}], 'updated_date': '2024-12-24T14:26:45.507772', 'created_date': '2016-06-24'}