Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2095493602', 'doi': 'https://doi.org/10.1136/ard.2003.012914', 'title': 'A randomised comparative study of the short term clinical and biological effects of intravenous pulse methylprednisolone and infliximab in patients with active rheumatoid arthritis despite methotrexate treatment', 'display_name': 'A randomised comparative study of the short term clinical and biological effects of intravenous pulse methylprednisolone and infliximab in patients with active rheumatoid arthritis despite methotrexate treatment', 'publication_year': 2004, 'publication_date': '2004-08-12', 'ids': {'openalex': 'https://openalex.org/W2095493602', 'doi': 'https://doi.org/10.1136/ard.2003.012914', 'mag': '2095493602', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/15308515', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/1755125'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1136/ard.2003.012914', 'pdf_url': 'https://ard.bmj.com/content/annrheumdis/63/9/1069.full.pdf', 'source': {'id': 'https://openalex.org/S25650217', 'display_name': 'Annals of the Rheumatic Diseases', 'issn_l': '0003-4967', 'issn': ['0003-4967', '1468-2060'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319945', 'host_organization_name': 'BMJ', 'host_organization_lineage': ['https://openalex.org/P4310319945'], 'host_organization_lineage_names': ['BMJ'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://ard.bmj.com/content/annrheumdis/63/9/1069.full.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5083576726', 'display_name': 'Patrick Durez', 'orcid': 'https://orcid.org/0000-0002-7156-2356'}, 'institutions': [{'id': 'https://openalex.org/I1315288073', 'display_name': 'Cliniques Universitaires Saint-Luc', 'ror': 'https://ror.org/03s4khd80', 'country_code': 'BE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1315288073']}], 'countries': ['BE'], 'is_corresponding': False, 'raw_author_name': 'Patrick Durez', 'raw_affiliation_strings': ['Rheumatology Department, Cliniques Universitaires Saint-Luc, Université catholique de Louvain, Bruxelles, Belgium,'], 'affiliations': [{'raw_affiliation_string': 'Rheumatology Department, Cliniques Universitaires Saint-Luc, Université catholique de Louvain, Bruxelles, Belgium,', 'institution_ids': ['https://openalex.org/I1315288073']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5069467112', 'display_name': 'A. Nzeusseu Toukap', 'orcid': 'https://orcid.org/0000-0003-0924-1735'}, 'institutions': [{'id': 'https://openalex.org/I1315288073', 'display_name': 'Cliniques Universitaires Saint-Luc', 'ror': 'https://ror.org/03s4khd80', 'country_code': 'BE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1315288073']}], 'countries': ['BE'], 'is_corresponding': False, 'raw_author_name': 'A Nzeusseu Toukap', 'raw_affiliation_strings': ['Rheumatology Department, Cliniques Universitaires Saint-Luc, Université catholique de Louvain, Belgium'], 'affiliations': [{'raw_affiliation_string': 'Rheumatology Department, Cliniques Universitaires Saint-Luc, Université catholique de Louvain, Belgium', 'institution_ids': ['https://openalex.org/I1315288073']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5005399691', 'display_name': 'Bernard Lauwerys', 'orcid': 'https://orcid.org/0000-0003-3243-6151'}, 'institutions': [{'id': 'https://openalex.org/I1315288073', 'display_name': 'Cliniques Universitaires Saint-Luc', 'ror': 'https://ror.org/03s4khd80', 'country_code': 'BE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1315288073']}], 'countries': ['BE'], 'is_corresponding': False, 'raw_author_name': 'Bernard Lauwerys', 'raw_affiliation_strings': ['Rheumatology Department, Cliniques Universitaires Saint-Luc, Université catholique de Louvain, Belgium'], 'affiliations': [{'raw_affiliation_string': 'Rheumatology Department, Cliniques Universitaires Saint-Luc, Université catholique de Louvain, Belgium', 'institution_ids': ['https://openalex.org/I1315288073']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5113867389', 'display_name': 'Daniel Manicourt', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1315288073', 'display_name': 'Cliniques Universitaires Saint-Luc', 'ror': 'https://ror.org/03s4khd80', 'country_code': 'BE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1315288073']}], 'countries': ['BE'], 'is_corresponding': False, 'raw_author_name': 'Daniel Manicourt', 'raw_affiliation_strings': ['Rheumatology Department, Cliniques Universitaires Saint-Luc, Université catholique de Louvain, Belgium'], 'affiliations': [{'raw_affiliation_string': 'Rheumatology Department, Cliniques Universitaires Saint-Luc, Université catholique de Louvain, Belgium', 'institution_ids': ['https://openalex.org/I1315288073']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5090277186', 'display_name': 'Patrick Verschueren', 'orcid': 'https://orcid.org/0000-0002-0340-3580'}, 'institutions': [{'id': 'https://openalex.org/I99464096', 'display_name': 'KU Leuven', 'ror': 'https://ror.org/05f950310', 'country_code': 'BE', 'type': 'education', 'lineage': ['https://openalex.org/I99464096']}, {'id': 'https://openalex.org/I2800231306', 'display_name': 'Universitair Ziekenhuis Leuven', 'ror': 'https://ror.org/0424bsv16', 'country_code': 'BE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2800231306']}], 'countries': ['BE'], 'is_corresponding': False, 'raw_author_name': 'P. Verschueren', 'raw_affiliation_strings': ['Rheumatology Department, UZ Gasthuisberg, Katholieke Universiteit Leuven, Belgium.'], 'affiliations': [{'raw_affiliation_string': 'Rheumatology Department, UZ Gasthuisberg, Katholieke Universiteit Leuven, Belgium.', 'institution_ids': ['https://openalex.org/I99464096', 'https://openalex.org/I2800231306']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5006123817', 'display_name': 'René Westhovens', 'orcid': 'https://orcid.org/0000-0002-3432-3073'}, 'institutions': [{'id': 'https://openalex.org/I2800231306', 'display_name': 'Universitair Ziekenhuis Leuven', 'ror': 'https://ror.org/0424bsv16', 'country_code': 'BE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2800231306']}, {'id': 'https://openalex.org/I99464096', 'display_name': 'KU Leuven', 'ror': 'https://ror.org/05f950310', 'country_code': 'BE', 'type': 'education', 'lineage': ['https://openalex.org/I99464096']}], 'countries': ['BE'], 'is_corresponding': False, 'raw_author_name': 'Rene Westhovens', 'raw_affiliation_strings': ['Rheumatology Department, UZ Gasthuisberg, Katholieke Universiteit Leuven, Belgium.'], 'affiliations': [{'raw_affiliation_string': 'Rheumatology Department, UZ Gasthuisberg, Katholieke Universiteit Leuven, Belgium.', 'institution_ids': ['https://openalex.org/I2800231306', 'https://openalex.org/I99464096']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5111666399', 'display_name': 'Jean-Pierre Devogelaer', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1315288073', 'display_name': 'Cliniques Universitaires Saint-Luc', 'ror': 'https://ror.org/03s4khd80', 'country_code': 'BE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1315288073']}], 'countries': ['BE'], 'is_corresponding': False, 'raw_author_name': 'Jean-Pierre Devogelaer', 'raw_affiliation_strings': ['Rheumatology Department, Cliniques Universitaires Saint-Luc, Université catholique de Louvain, Belgium'], 'affiliations': [{'raw_affiliation_string': 'Rheumatology Department, Cliniques Universitaires Saint-Luc, Université catholique de Louvain, Belgium', 'institution_ids': ['https://openalex.org/I1315288073']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5105889848', 'display_name': 'Frédéric Houssiau', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1315288073', 'display_name': 'Cliniques Universitaires Saint-Luc', 'ror': 'https://ror.org/03s4khd80', 'country_code': 'BE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1315288073']}], 'countries': ['BE'], 'is_corresponding': False, 'raw_author_name': 'Frédéric Houssiau', 'raw_affiliation_strings': ['Rheumatology Department, Cliniques Universitaires Saint-Luc, Université catholique de Louvain, Belgium'], 'affiliations': [{'raw_affiliation_string': 'Rheumatology Department, Cliniques Universitaires Saint-Luc, Université catholique de Louvain, Belgium', 'institution_ids': ['https://openalex.org/I1315288073']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 3, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 3.213, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 45, 'citation_normalized_percentile': {'value': 0.815687, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 92, 'max': 93}, 'biblio': {'volume': '63', 'issue': '9', 'first_page': '1069', 'last_page': '1074'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10200', 'display_name': 'Rheumatoid Arthritis Research and Therapies', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/2745', 'display_name': 'Rheumatology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10200', 'display_name': 'Rheumatoid Arthritis Research and Therapies', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/2745', 'display_name': 'Rheumatology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11616', 'display_name': 'Autoimmune and Inflammatory Disorders Research', 'score': 0.9963, 'subfield': {'id': 'https://openalex.org/subfields/2720', 'display_name': 'Hematology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/group-b', 'display_name': 'Group B', 'score': 0.4482404}], 'concepts': [{'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.96925515}, {'id': 'https://openalex.org/C2777138892', 'wikidata': 'https://www.wikidata.org/wiki/Q415264', 'display_name': 'Infliximab', 'level': 3, 'score': 0.8942664}, {'id': 'https://openalex.org/C2777575956', 'wikidata': 'https://www.wikidata.org/wiki/Q187255', 'display_name': 'Rheumatoid arthritis', 'level': 2, 'score': 0.83706}, {'id': 'https://openalex.org/C2781059491', 'wikidata': 'https://www.wikidata.org/wiki/Q422232', 'display_name': 'Methotrexate', 'level': 2, 'score': 0.7831209}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.70442724}, {'id': 'https://openalex.org/C2780372218', 'wikidata': 'https://www.wikidata.org/wiki/Q417222', 'display_name': 'Methylprednisolone', 'level': 2, 'score': 0.59138703}, {'id': 'https://openalex.org/C90924648', 'wikidata': 'https://www.wikidata.org/wiki/Q120569', 'display_name': 'Gastroenterology', 'level': 1, 'score': 0.59044504}, {'id': 'https://openalex.org/C198451711', 'wikidata': 'https://www.wikidata.org/wiki/Q327657', 'display_name': 'Rheumatology', 'level': 2, 'score': 0.45915097}, {'id': 'https://openalex.org/C2777785397', 'wikidata': 'https://www.wikidata.org/wiki/Q492194', 'display_name': 'Group B', 'level': 2, 'score': 0.4482404}, {'id': 'https://openalex.org/C141071460', 'wikidata': 'https://www.wikidata.org/wiki/Q40821', 'display_name': 'Surgery', 'level': 1, 'score': 0.3338179}, {'id': 'https://openalex.org/C17991360', 'wikidata': 'https://www.wikidata.org/wiki/Q21173843', 'display_name': 'Tumor necrosis factor alpha', 'level': 2, 'score': 0.24884477}], 'mesh': [{'descriptor_ui': 'D000911', 'descriptor_name': 'Antibodies, Monoclonal', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D018501', 'descriptor_name': 'Antirheumatic Agents', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D001172', 'descriptor_name': 'Arthritis, Rheumatoid', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D008775', 'descriptor_name': 'Methylprednisolone', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D000328', 'descriptor_name': 'Adult', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000368', 'descriptor_name': 'Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000911', 'descriptor_name': 'Antibodies, Monoclonal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018501', 'descriptor_name': 'Antirheumatic Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001172', 'descriptor_name': 'Arthritis, Rheumatoid', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001172', 'descriptor_name': 'Arthritis, Rheumatoid', 'qualifier_ui': 'Q000534', 'qualifier_name': 'rehabilitation', 'is_major_topic': False}, {'descriptor_ui': 'D001172', 'descriptor_name': 'Arthritis, Rheumatoid', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': False}, {'descriptor_ui': 'D002097', 'descriptor_name': 'C-Reactive Protein', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002097', 'descriptor_name': 'C-Reactive Protein', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D004359', 'descriptor_name': 'Drug Therapy, Combination', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005938', 'descriptor_name': 'Glucocorticoids', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005938', 'descriptor_name': 'Glucocorticoids', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007166', 'descriptor_name': 'Immunosuppressive Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007166', 'descriptor_name': 'Immunosuppressive Agents', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D000069285', 'descriptor_name': 'Infliximab', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015850', 'descriptor_name': 'Interleukin-6', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015850', 'descriptor_name': 'Interleukin-6', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019278', 'descriptor_name': 'Matrix Metalloproteinase 3', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019278', 'descriptor_name': 'Matrix Metalloproteinase 3', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': False}, {'descriptor_ui': 'D008727', 'descriptor_name': 'Methotrexate', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008727', 'descriptor_name': 'Methotrexate', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D008775', 'descriptor_name': 'Methylprednisolone', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008875', 'descriptor_name': 'Middle Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011788', 'descriptor_name': 'Quality of Life', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012720', 'descriptor_name': 'Severity of Illness Index', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016037', 'descriptor_name': 'Single-Blind Method', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 5, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1136/ard.2003.012914', 'pdf_url': 'https://ard.bmj.com/content/annrheumdis/63/9/1069.full.pdf', 'source': {'id': 'https://openalex.org/S25650217', 'display_name': 'Annals of the Rheumatic Diseases', 'issn_l': '0003-4967', 'issn': ['0003-4967', '1468-2060'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319945', 'host_organization_name': 'BMJ', 'host_organization_lineage': ['https://openalex.org/P4310319945'], 'host_organization_lineage_names': ['BMJ'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc1755125', 'pdf_url': 'https://europepmc.org/articles/pmc1755125?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1755125', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'http://ard.bmj.com/cgi/content/short/63/9/1069', 'pdf_url': 'http://ard.bmj.com/content/63/9/1069.full.pdf', 'source': {'id': 'https://openalex.org/S128516502', 'display_name': 'Notes and Queries', 'issn_l': '0029-3970', 'issn': ['0029-3970', '1471-6941'], 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/15308515', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1136/ard.2003.012914', 'pdf_url': 'https://ard.bmj.com/content/annrheumdis/63/9/1069.full.pdf', 'source': {'id': 'https://openalex.org/S25650217', 'display_name': 'Annals of the Rheumatic Diseases', 'issn_l': '0003-4967', 'issn': ['0003-4967', '1468-2060'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319945', 'host_organization_name': 'BMJ', 'host_organization_lineage': ['https://openalex.org/P4310319945'], 'host_organization_lineage_names': ['BMJ'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 27, 'referenced_works': ['https://openalex.org/W1967344057', 'https://openalex.org/W1976364148', 'https://openalex.org/W1977489783', 'https://openalex.org/W1978538377', 'https://openalex.org/W1979364075', 'https://openalex.org/W1985763670', 'https://openalex.org/W2000846863', 'https://openalex.org/W2012215203', 'https://openalex.org/W2016873538', 'https://openalex.org/W2019878449', 'https://openalex.org/W2026221496', 'https://openalex.org/W2045615786', 'https://openalex.org/W2052193957', 'https://openalex.org/W2065419533', 'https://openalex.org/W2084386397', 'https://openalex.org/W2111959500', 'https://openalex.org/W2115068422', 'https://openalex.org/W2123784732', 'https://openalex.org/W2134444532', 'https://openalex.org/W2137953708', 'https://openalex.org/W2141486767', 'https://openalex.org/W2152348310', 'https://openalex.org/W2314052274', 'https://openalex.org/W2319957449', 'https://openalex.org/W2408872721', 'https://openalex.org/W2418784159', 'https://openalex.org/W4243498114'], 'related_works': ['https://openalex.org/W4251398023', 'https://openalex.org/W2409753288', 'https://openalex.org/W2351135524', 'https://openalex.org/W2330650717', 'https://openalex.org/W2133832905', 'https://openalex.org/W2093504865', 'https://openalex.org/W2090686119', 'https://openalex.org/W2072640801', 'https://openalex.org/W2000293965', 'https://openalex.org/W1897160555'], 'abstract_inverted_index': {'To': [0], 'compare': [1], 'the': [2, 78, 113, 128, 137, 152, 164, 178], 'short': [3, 190], 'term': [4, 191], 'clinical': [5, 219], 'and': [6, 15, 61, 93, 122, 130, 143, 233], 'biological': [7, 226], 'effects': [8], 'of': [9, 45, 53, 72, 151, 208, 221], 'intravenous': [10], '(i.v.)': [11], 'pulse': [12, 203], 'methylprednisolone': [13], '(MP)': [14], 'infliximab': [16], '(IFX)': [17], 'in': [18, 101, 112, 139, 163, 177, 186, 205, 216], 'patients': [19, 126, 187, 209], 'with': [20, 30, 95, 156, 210, 214], 'severe': [21, 211], 'active': [22, 31], 'rheumatoid': [23], 'arthritis': [24], '(RA)': [25], 'despite': [26, 33], 'methotrexate': [27], '(MTX)': [28], 'treatment.Patients': [29], 'RA': [32], 'MTX': [34], 'treatment': [35], 'were': [36, 64, 87, 184], 'randomly': [37], 'allocated': [38], 'to': [39], 'receive': [40], 'a': [41, 206], 'single': [42], 'i.v.': [43, 51], 'infusion': [44], 'MP': [46, 146, 157, 202], '(1': [47], 'g)': [48], 'or': [49], 'three': [50], 'infusions': [52], 'IFX': [54, 114, 125, 165, 179], '(3': [55], 'mg/kg)': [56], 'on': [57], 'weeks': [58, 91], '0,': [59], '2,': [60], '6.': [62], 'Patients': [63], '"blindly"': [65], 'evaluated': [66, 76], 'for': [67], 'disease': [68, 222], 'activity': [69, 103, 223], 'measures.': [70], 'Quality': [71], 'life': [73], '(QoL)': [74], 'was': [75, 99, 136], 'through': [77], 'SF-36': [79], 'health': [80], 'survey.': [81], 'Serum': [82, 167], 'matrix': [83], 'metalloproteinase-3': [84], '(MMP-3)': [85], 'titres': [86, 169], 'measured': [88], 'at': [89, 174], 'baseline,': [90, 96], '2': [92], '6.Compared': [94], 'significant': [97], 'improvement': [98, 215], 'noted': [100], 'all': [102], 'measures,': [104], 'including': [105], 'serum': [106, 231], 'C': [107], 'reactive': [108], 'protein': [109], '(CRP)': [110], 'titres,': [111], 'group': [115], 'only.': [116], 'At': [117], 'week': [118, 175], '14,': [119], '6/9': [120], '(67%)': [121], '4/9': [123], '(44%)': [124], 'met': [127], 'ACR20': [129], '50': [131], 'response': [132], 'criteria,': [133], 'while': [134, 181], 'this': [135], 'case': [138], 'only': [140, 218], '1/12': [141], '(8%)': [142], '0/12': [144], '(0%)': [145], 'patients,': [147], 'respectively': [148], '(p<0.05).': [149], 'None': [150], 'QoL': [153], 'scales': [154], 'improved': [155], 'treatment,': [158], 'whereas': [159], 'some': [160], 'did': [161], 'so': [162], 'group.': [166], 'MMP-3': [168, 234], 'significantly': [170], 'decreased': [171], '(41%': [172], 'drop)': [173], '6': [176], 'group,': [180], 'no': [182], 'changes': [183], 'seen': [185], 'given': [188], 'MP.This': [189], 'randomised': [192], 'comparative': [193], 'study': [194], 'demonstrates': [195], 'that': [196], 'TNF': [197], 'blockade': [198], 'is': [199], 'better': [200], 'than': [201], 'therapy': [204], 'subset': [207], 'refractory': [212], 'RA,': [213], 'not': [217], 'parameters': [220], 'but': [224], 'also': [225], 'inflammatory': [227], 'indices,': [228], 'such': [229], 'as': [230], 'CRP': [232], 'titres.': [235]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2095493602', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 3}, {'year': 2016, 'cited_by_count': 3}, {'year': 2015, 'cited_by_count': 2}, {'year': 2014, 'cited_by_count': 2}, {'year': 2013, 'cited_by_count': 1}, {'year': 2012, 'cited_by_count': 4}], 'updated_date': '2024-12-14T18:06:06.487027', 'created_date': '2016-06-24'}