Title: Effects of lamotrigine on nocturnal sleep, daytime somnolence and cognitive functions in focal epilepsy
Abstract: Acta Neurologica ScandinavicaVolume 102, Issue 2 p. 81-86 Effects of lamotrigine on nocturnal sleep, daytime somnolence and cognitive functions in focal epilepsy F. Placidi, F. Placidi Clinica Neurologica Università Tor Vergata,Search for more papers by this authorM. G. Marciani, M. G. Marciani Clinica Neurologica Università Tor Vergata, IRCCS Clinica S.Lucia Roma,Search for more papers by this authorM. Diomedi, M. Diomedi Clinica Neurologica Università Tor Vergata,Search for more papers by this authorA. Scalise, A. Scalise Clinica Neurologica Università Tor Vergata, IRCCS Clinica S.Lucia Roma,Search for more papers by this authorP. Giacomini, P. Giacomini Clinica Neurologica, Università degli Studi di Roma La Sapienza,Search for more papers by this authorG. L. Gigli, G. L. Gigli Divisione Neurologica, Ospedale S. Maria della Misericordia, Udine, ItalySearch for more papers by this author F. Placidi, F. Placidi Clinica Neurologica Università Tor Vergata,Search for more papers by this authorM. G. Marciani, M. G. Marciani Clinica Neurologica Università Tor Vergata, IRCCS Clinica S.Lucia Roma,Search for more papers by this authorM. Diomedi, M. Diomedi Clinica Neurologica Università Tor Vergata,Search for more papers by this authorA. Scalise, A. Scalise Clinica Neurologica Università Tor Vergata, IRCCS Clinica S.Lucia Roma,Search for more papers by this authorP. Giacomini, P. Giacomini Clinica Neurologica, Università degli Studi di Roma La Sapienza,Search for more papers by this authorG. L. Gigli, G. L. Gigli Divisione Neurologica, Ospedale S. Maria della Misericordia, Udine, ItalySearch for more papers by this author First published: 24 December 2001 https://doi.org/10.1034/j.1600-0404.2000.102002081.xCitations: 53 Dr Fabio Placidi, Clinica Neurologica, Dipartimento di Neuroscienze,Università di Roma Tor Vergata,Via O. Raimondo 8,00,173 Roma, ItalyTel: ++39–6-59,14436Fax: ++39–6-59,22086e-mail: [email protected] AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract Objectives– The aim of our study was to evaluate possible changes in nocturnal sleep, daytime somnolence and cognitive functions induced by add-on therapy with lamotrigine (LTG). Material and methods– Thirteen patients affected by seizures resistant to common antiepileptic drugs (AEDs) underwent nocturnal polysomnographic monitorings, daytime somnolence evaluations and a neuropsychological battery before and after 3 months of treatment with LTG. Results– With LTG therapy we observed a significant increase in REM sleep and a significant reduction in the number of entries into REM and stage shifts. No significant correlation was observed between the decrease in nocturnal epileptiform activity and the increase in REM sleep. Other sleep parameters were unmodified. No significant changes were observed in daytime somnolence and in cognitive performances. Conclusion– LTG may produce positive effects on epileptic seizures and interictal abnormalities without interfering negatively on REM sleep, with improvement of sleep stability and without changes in daytime somnolence and neuropsychological performances. For these reasonsit could be an important drug for improving epileptic patients'quality of life. Citing Literature Volume102, Issue2August 2000Pages 81-86 RelatedInformation
Publication Year: 2000
Publication Date: 2000-08-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 76
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