Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2095013915', 'doi': 'https://doi.org/10.1038/nri1184', 'title': 'Signalling pathways of the TNF superfamily: a double-edged sword', 'display_name': 'Signalling pathways of the TNF superfamily: a double-edged sword', 'publication_year': 2003, 'publication_date': '2003-09-01', 'ids': {'openalex': 'https://openalex.org/W2095013915', 'doi': 'https://doi.org/10.1038/nri1184', 'mag': '2095013915', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/12949498'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1038/nri1184', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S93373720', 'display_name': 'Nature reviews. Immunology', 'issn_l': '1474-1733', 'issn': ['1474-1733', '1474-1741'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319908', 'host_organization_name': 'Nature Portfolio', 'host_organization_lineage': ['https://openalex.org/P4310319908', 'https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Nature Portfolio', 'Springer Nature'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5048675624', 'display_name': 'Bharat B. Aggarwal', 'orcid': 'https://orcid.org/0000-0003-3534-2898'}, 'institutions': [], 'countries': [], 'is_corresponding': True, 'raw_author_name': 'Bharat B. Aggarwal', 'raw_affiliation_strings': ['Experimental Therapeutics'], 'affiliations': [{'raw_affiliation_string': 'Experimental Therapeutics', 'institution_ids': []}]}], 'institution_assertions': [], 'countries_distinct_count': 0, 'institutions_distinct_count': 0, 'corresponding_author_ids': ['https://openalex.org/A5048675624'], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 12.843, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 2605, 'citation_normalized_percentile': {'value': 0.999693, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '3', 'issue': '9', 'first_page': '745', 'last_page': '756'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10294', 'display_name': 'Cell death mechanisms and regulation', 'score': 0.9964, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10294', 'display_name': 'Cell death mechanisms and regulation', 'score': 0.9964, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11591', 'display_name': 'NF-κB Signaling Pathways', 'score': 0.9963, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10371', 'display_name': 'Immune Response and Inflammation', 'score': 0.9956, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [], 'concepts': [{'id': 'https://openalex.org/C17991360', 'wikidata': 'https://www.wikidata.org/wiki/Q21173843', 'display_name': 'Tumor necrosis factor alpha', 'level': 2, 'score': 0.6996696}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.606828}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.55925524}, {'id': 'https://openalex.org/C8891405', 'wikidata': 'https://www.wikidata.org/wiki/Q1059', 'display_name': 'Immune system', 'level': 2, 'score': 0.49556696}, {'id': 'https://openalex.org/C2777575956', 'wikidata': 'https://www.wikidata.org/wiki/Q187255', 'display_name': 'Rheumatoid arthritis', 'level': 2, 'score': 0.4908119}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.47353977}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.46296242}, {'id': 'https://openalex.org/C154317977', 'wikidata': 'https://www.wikidata.org/wiki/Q376266', 'display_name': 'Cytotoxic T cell', 'level': 3, 'score': 0.45862195}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.44613108}, {'id': 'https://openalex.org/C2776033226', 'wikidata': 'https://www.wikidata.org/wiki/Q828410', 'display_name': 'Osteoclast', 'level': 3, 'score': 0.4276138}, {'id': 'https://openalex.org/C109159458', 'wikidata': 'https://www.wikidata.org/wiki/Q919283', 'display_name': 'Haematopoiesis', 'level': 3, 'score': 0.42101312}, {'id': 'https://openalex.org/C673006', 'wikidata': 'https://www.wikidata.org/wiki/Q4941581', 'display_name': 'Bone resorption', 'level': 2, 'score': 0.41828266}, {'id': 'https://openalex.org/C28328180', 'wikidata': 'https://www.wikidata.org/wiki/Q48196', 'display_name': 'Stem cell', 'level': 2, 'score': 0.27203876}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.14112458}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.08943319}, {'id': 'https://openalex.org/C202751555', 'wikidata': 'https://www.wikidata.org/wiki/Q221681', 'display_name': 'In vitro', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D008233', 'descriptor_name': 'Lymphotoxin-alpha', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D018124', 'descriptor_name': 'Receptors, Tumor Necrosis Factor', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D014409', 'descriptor_name': 'Tumor Necrosis Factor-alpha', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001327', 'descriptor_name': 'Autoimmune Diseases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001327', 'descriptor_name': 'Autoimmune Diseases', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': False}, {'descriptor_ui': 'D001327', 'descriptor_name': 'Autoimmune Diseases', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D002352', 'descriptor_name': 'Carrier Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002352', 'descriptor_name': 'Carrier Proteins', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008024', 'descriptor_name': 'Ligands', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008233', 'descriptor_name': 'Lymphotoxin-alpha', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008233', 'descriptor_name': 'Lymphotoxin-alpha', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}, {'descriptor_ui': 'D008565', 'descriptor_name': 'Membrane Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008565', 'descriptor_name': 'Membrane Proteins', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016328', 'descriptor_name': 'NF-kappa B', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016328', 'descriptor_name': 'NF-kappa B', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D018124', 'descriptor_name': 'Receptors, Tumor Necrosis Factor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014409', 'descriptor_name': 'Tumor Necrosis Factor-alpha', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}, {'descriptor_ui': 'D014409', 'descriptor_name': 'Tumor Necrosis Factor-alpha', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1038/nri1184', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S93373720', 'display_name': 'Nature reviews. Immunology', 'issn_l': '1474-1733', 'issn': ['1474-1733', '1474-1741'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319908', 'host_organization_name': 'Nature Portfolio', 'host_organization_lineage': ['https://openalex.org/P4310319908', 'https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Nature Portfolio', 'Springer Nature'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/12949498', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'score': 0.81, 'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 124, 'referenced_works': ['https://openalex.org/W1498427877', 'https://openalex.org/W1503094954', 'https://openalex.org/W1527985047', 'https://openalex.org/W1534645474', 'https://openalex.org/W1537686225', 'https://openalex.org/W1549053710', 'https://openalex.org/W1571951314', 'https://openalex.org/W1577393853', 'https://openalex.org/W1585093254', 'https://openalex.org/W1593830931', 'https://openalex.org/W1594149454', 'https://openalex.org/W1602891624', 'https://openalex.org/W1627715946', 'https://openalex.org/W1650001464', 'https://openalex.org/W1764140709', 'https://openalex.org/W1874909451', 'https://openalex.org/W1910698471', 'https://openalex.org/W1919248155', 'https://openalex.org/W1919752579', 'https://openalex.org/W1963820539', 'https://openalex.org/W1965404141', 'https://openalex.org/W1966347912', 'https://openalex.org/W1968295892', 'https://openalex.org/W1968401667', 'https://openalex.org/W1973792489', 'https://openalex.org/W1977872674', 'https://openalex.org/W1978018492', 'https://openalex.org/W1978019581', 'https://openalex.org/W1979003732', 'https://openalex.org/W1979595147', 'https://openalex.org/W1980289166', 'https://openalex.org/W1980773490', 'https://openalex.org/W1980919524', 'https://openalex.org/W1981419744', 'https://openalex.org/W1984696190', 'https://openalex.org/W1985720487', 'https://openalex.org/W1986301169', 'https://openalex.org/W1988210099', 'https://openalex.org/W1988306622', 'https://openalex.org/W1989565558', 'https://openalex.org/W1989783048', 'https://openalex.org/W1993906107', 'https://openalex.org/W1993928278', 'https://openalex.org/W2000647744', 'https://openalex.org/W2002507218', 'https://openalex.org/W2002865337', 'https://openalex.org/W2004520015', 'https://openalex.org/W2009085926', 'https://openalex.org/W2012739094', 'https://openalex.org/W2013052118', 'https://openalex.org/W2015907913', 'https://openalex.org/W2018915861', 'https://openalex.org/W2022930571', 'https://openalex.org/W2029871546', 'https://openalex.org/W2034433882', 'https://openalex.org/W2034518007', 'https://openalex.org/W2038118195', 'https://openalex.org/W2041466047', 'https://openalex.org/W2042087846', 'https://openalex.org/W2047123230', 'https://openalex.org/W2048299560', 'https://openalex.org/W2049189022', 'https://openalex.org/W2050702634', 'https://openalex.org/W2050720508', 'https://openalex.org/W2051320963', 'https://openalex.org/W2053242236', 'https://openalex.org/W2056217426', 'https://openalex.org/W2057123987', 'https://openalex.org/W2057258241', 'https://openalex.org/W2059738959', 'https://openalex.org/W2060019843', 'https://openalex.org/W2060426018', 'https://openalex.org/W2060960232', 'https://openalex.org/W2064518631', 'https://openalex.org/W2065297127', 'https://openalex.org/W2065511283', 'https://openalex.org/W2067125561', 'https://openalex.org/W2067142683', 'https://openalex.org/W2067680656', 'https://openalex.org/W2070885630', 'https://openalex.org/W2072380594', 'https://openalex.org/W2074881372', 'https://openalex.org/W2075813138', 'https://openalex.org/W2080856124', 'https://openalex.org/W2083726090', 'https://openalex.org/W2085429049', 'https://openalex.org/W2086255604', 'https://openalex.org/W2087221993', 'https://openalex.org/W2089244519', 'https://openalex.org/W2090685205', 'https://openalex.org/W2091627659', 'https://openalex.org/W2092508425', 'https://openalex.org/W2094244560', 'https://openalex.org/W2094356159', 'https://openalex.org/W2094374305', 'https://openalex.org/W2094835614', 'https://openalex.org/W2102585554', 'https://openalex.org/W2102986716', 'https://openalex.org/W2107174064', 'https://openalex.org/W2111258927', 'https://openalex.org/W2120951438', 'https://openalex.org/W2124202816', 'https://openalex.org/W2126207814', 'https://openalex.org/W2127971170', 'https://openalex.org/W2129249108', 'https://openalex.org/W2129651548', 'https://openalex.org/W2129668511', 'https://openalex.org/W2130988210', 'https://openalex.org/W2134714663', 'https://openalex.org/W2134897759', 'https://openalex.org/W2142790993', 'https://openalex.org/W2145626047', 'https://openalex.org/W2150373615', 'https://openalex.org/W2153296278', 'https://openalex.org/W2159719957', 'https://openalex.org/W2159722075', 'https://openalex.org/W2166022914', 'https://openalex.org/W2168796193', 'https://openalex.org/W2168945225', 'https://openalex.org/W2179862924', 'https://openalex.org/W2285855050', 'https://openalex.org/W2329873423', 'https://openalex.org/W2411683610', 'https://openalex.org/W2470223656'], 'related_works': ['https://openalex.org/W4280520697', 'https://openalex.org/W4200305651', 'https://openalex.org/W2785763207', 'https://openalex.org/W2346299808', 'https://openalex.org/W2183727096', 'https://openalex.org/W2166958762', 'https://openalex.org/W2130549848', 'https://openalex.org/W2011503572', 'https://openalex.org/W1975196675', 'https://openalex.org/W1514700928'], 'abstract_inverted_index': None, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2095013915', 'counts_by_year': [{'year': 2024, 'cited_by_count': 78}, {'year': 2023, 'cited_by_count': 114}, {'year': 2022, 'cited_by_count': 121}, {'year': 2021, 'cited_by_count': 116}, {'year': 2020, 'cited_by_count': 126}, {'year': 2019, 'cited_by_count': 109}, {'year': 2018, 'cited_by_count': 112}, {'year': 2017, 'cited_by_count': 129}, {'year': 2016, 'cited_by_count': 107}, {'year': 2015, 'cited_by_count': 142}, {'year': 2014, 'cited_by_count': 129}, {'year': 2013, 'cited_by_count': 119}, {'year': 2012, 'cited_by_count': 163}], 'updated_date': '2025-01-10T17:04:53.312396', 'created_date': '2016-06-24'}