Title: Ion-pair extraction of some cinchona alkaloids with various chiral organic anions
Abstract: Some cinchona alkaloids, the quinine/quinidine and cinchonine/cinchonidine pairs, are extracted by ion-pair formation with some chiral amino acids and d-camphorsulfonic acid. Their extraction behaviors are examined and the differences between the two isomers are compared. These alkaloids are extracted into chloroform in the pH range 4–7 as the 1:1 ion-pair with the organic acid. The relationship between the distribution ratio of the ion-pair and pH is discussed. In the pH range between the pKa1 and pKa2 values of these alkaloids, logarithmic plots of the distribution ratio are independent of pH. In this pH region, the extraction constants are determined and the differences caused by the ion-pair formation are discussed.
Publication Year: 1988
Publication Date: 1988-01-01
Language: en
Type: article
Indexed In: ['crossref']
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Cited By Count: 8
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