Abstract: The addition of ethanol or other aliphatic alcohols to rat brain membranes strongly inhibits binding of enkephalins at concentrations at which little inhibition of opiate alkaloids is seen. Inhibition is reversible, and potency increases with chain length of the alcohol. The results suggest that δ receptors are considerably more sensitive to alcohols than μ receptors. This is the first demonstration of selective inhibition of one of the postulated classes of opiate receptors by a reagent that is not a ligand for the receptor.
Publication Year: 1981
Publication Date: 1981-10-23
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
Access and Citation
Cited By Count: 150
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot