Title: Differentiation of the Gastric Mucosa I. Role of histamine in control of function and integrity of oxyntic mucosa: understanding gastric physiology through disruption of targeted genes
Abstract: Many physiological functions of the stomach depend on an intact mucosal integrity; function reflects structure and vice versa. Histamine in the stomach is synthesized by histidine decarboxylase (HDC), stored in enterochromaffin-like (ECL) cells, and released in response to gastrin, acting on CCK 2 receptors on the ECL cells. Mobilized ECL cell histamine stimulates histamine H 2 receptors on the parietal cells, resulting in acid secretion. The parietal cells express H 2 , M 3 , and CCK 2 receptors and somatostatin sst 2 receptors. This review discusses the consequences of disrupting genes that are important for ECL cell histamine release and synthesis (HDC, gastrin, and CCK 2 receptor genes) and genes that are important for “cross-talk” between H 2 receptors and other receptors on the parietal cell (CCK 2 , M 3 , and sst 2 receptors). Such analysis may provide insight into the functional significance of gastric histamine.
Publication Year: 2006
Publication Date: 2006-09-07
Language: en
Type: review
Indexed In: ['crossref', 'pubmed']
Access and Citation
Cited By Count: 44
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