Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2094640076', 'doi': 'https://doi.org/10.1002/cne.23145', 'title': 'Neuroanatomy of melanocortin‐4 receptor pathway in the lateral hypothalamic area', 'display_name': 'Neuroanatomy of melanocortin‐4 receptor pathway in the lateral hypothalamic area', 'publication_year': 2012, 'publication_date': '2012-10-20', 'ids': {'openalex': 'https://openalex.org/W2094640076', 'doi': 'https://doi.org/10.1002/cne.23145', 'mag': '2094640076', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/22605619', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/3652326'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1002/cne.23145', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4210186231', 'display_name': 'The Journal of Comparative Neurology', 'issn_l': '0021-9967', 'issn': ['0021-9967', '1096-9861'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://europepmc.org/articles/pmc3652326?pdf=render', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5030366359', 'display_name': 'Huxing Cui', 'orcid': 'https://orcid.org/0000-0002-8627-8534'}, 'institutions': [{'id': 'https://openalex.org/I867280407', 'display_name': 'The University of Texas Southwestern Medical Center', 'ror': 'https://ror.org/05byvp690', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I867280407']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Huxing Cui', 'raw_affiliation_strings': ['Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, Texas 75390-9127, USA.'], 'affiliations': [{'raw_affiliation_string': 'Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, Texas 75390-9127, USA.', 'institution_ids': ['https://openalex.org/I867280407']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5103911985', 'display_name': 'Jong Woo Sohn', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I867280407', 'display_name': 'The University of Texas Southwestern Medical Center', 'ror': 'https://ror.org/05byvp690', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I867280407']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jong Woo Sohn', 'raw_affiliation_strings': ['University of Texas, Southwestern Medical Center'], 'affiliations': [{'raw_affiliation_string': 'University of Texas, Southwestern Medical Center', 'institution_ids': ['https://openalex.org/I867280407']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5062103230', 'display_name': 'Laurent Gautron', 'orcid': 'https://orcid.org/0000-0003-3609-7441'}, 'institutions': [{'id': 'https://openalex.org/I867280407', 'display_name': 'The University of Texas Southwestern Medical Center', 'ror': 'https://ror.org/05byvp690', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I867280407']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Laurent Gautron', 'raw_affiliation_strings': ['Departments of Internal Medicine and Pharmacology, Division of Hypothalamic Research, The University of Texas Southwestern Medical Center, Dallas, Texas, 75390-9127'], 'affiliations': [{'raw_affiliation_string': 'Departments of Internal Medicine and Pharmacology, Division of Hypothalamic Research, The University of Texas Southwestern Medical Center, Dallas, Texas, 75390-9127', 'institution_ids': ['https://openalex.org/I867280407']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5002878480', 'display_name': 'Hisayuki Funahashi', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I119182057', 'display_name': 'Showa University', 'ror': 'https://ror.org/04mzk4q39', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I119182057']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Hisayuki Funahashi', 'raw_affiliation_strings': ['Showa University;'], 'affiliations': [{'raw_affiliation_string': 'Showa University;', 'institution_ids': ['https://openalex.org/I119182057']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5016931636', 'display_name': 'Kevin W. Williams', 'orcid': 'https://orcid.org/0000-0002-8434-8658'}, 'institutions': [{'id': 'https://openalex.org/I867280407', 'display_name': 'The University of Texas Southwestern Medical Center', 'ror': 'https://ror.org/05byvp690', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I867280407']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Kevin W. Williams', 'raw_affiliation_strings': ['Departments of Internal Medicine and Pharmacology, Division of Hypothalamic Research, The University of Texas Southwestern Medical Center, Dallas, Texas, 75390-9127'], 'affiliations': [{'raw_affiliation_string': 'Departments of Internal Medicine and Pharmacology, Division of Hypothalamic Research, The University of Texas Southwestern Medical Center, Dallas, Texas, 75390-9127', 'institution_ids': ['https://openalex.org/I867280407']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5047342979', 'display_name': 'Joel K. Elmquist', 'orcid': 'https://orcid.org/0000-0001-6929-6370'}, 'institutions': [{'id': 'https://openalex.org/I867280407', 'display_name': 'The University of Texas Southwestern Medical Center', 'ror': 'https://ror.org/05byvp690', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I867280407']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Joel K. Elmquist', 'raw_affiliation_strings': ['Departments of Internal Medicine and Pharmacology, Division of Hypothalamic Research, The University of Texas Southwestern Medical Center, Dallas, Texas, 75390-9127'], 'affiliations': [{'raw_affiliation_string': 'Departments of Internal Medicine and Pharmacology, Division of Hypothalamic Research, The University of Texas Southwestern Medical Center, Dallas, Texas, 75390-9127', 'institution_ids': ['https://openalex.org/I867280407']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5045678774', 'display_name': 'Michael Lutter', 'orcid': 'https://orcid.org/0000-0002-1612-1398'}, 'institutions': [{'id': 'https://openalex.org/I126307644', 'display_name': 'University of Iowa', 'ror': 'https://ror.org/036jqmy94', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I126307644']}, {'id': 'https://openalex.org/I867280407', 'display_name': 'The University of Texas Southwestern Medical Center', 'ror': 'https://ror.org/05byvp690', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I867280407']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Michael Lutter', 'raw_affiliation_strings': ['University of Iowa', 'University of Texas Southwestern Medical Center'], 'affiliations': [{'raw_affiliation_string': 'University of Iowa', 'institution_ids': ['https://openalex.org/I126307644']}, {'raw_affiliation_string': 'University of Texas Southwestern Medical Center', 'institution_ids': ['https://openalex.org/I867280407']}]}], 'countries_distinct_count': 2, 'institutions_distinct_count': 3, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 3.208, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 74, 'citation_normalized_percentile': {'value': 0.873263, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 97, 'max': 98}, 'biblio': {'volume': '520', 'issue': '18', 'first_page': '4168', 'last_page': '4183'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10489', 'display_name': 'Neuroendocrine Regulation of Appetite and Body Weight', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2807', 'display_name': 'Endocrine and Autonomic Systems'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10489', 'display_name': 'Neuroendocrine Regulation of Appetite and Body Weight', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2807', 'display_name': 'Endocrine and Autonomic Systems'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11584', 'display_name': "Sweeteners' Taste and Impact on Health", 'score': 0.9982, 'subfield': {'id': 'https://openalex.org/subfields/2916', 'display_name': 'Nutrition and Dietetics'}, 'field': {'id': 'https://openalex.org/fields/29', 'display_name': 'Nursing'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11144', 'display_name': 'Melanin Pigmentation in Mammalian Skin', 'score': 0.9748, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/melanocortin-system', 'display_name': 'Melanocortin System', 'score': 0.575678}, {'id': 'https://openalex.org/keywords/retrograde-tracing', 'display_name': 'Retrograde tracing', 'score': 0.539908}, {'id': 'https://openalex.org/keywords/dorsal-raphe-nucleus', 'display_name': 'Dorsal raphe nucleus', 'score': 0.5234184}, {'id': 'https://openalex.org/keywords/hypothalamus', 'display_name': 'Hypothalamus', 'score': 0.504146}, {'id': 'https://openalex.org/keywords/energy-homeostasis', 'display_name': 'Energy homeostasis', 'score': 0.5036418}, {'id': 'https://openalex.org/keywords/lateral-parabrachial-nucleus', 'display_name': 'Lateral parabrachial nucleus', 'score': 0.49406055}, {'id': 'https://openalex.org/keywords/lateral-hypothalamus', 'display_name': 'Lateral hypothalamus', 'score': 0.4319644}, {'id': 'https://openalex.org/keywords/melanocortin-4-receptor', 'display_name': 'Melanocortin 4 receptor', 'score': 0.41903493}], 'concepts': [{'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.6879982}, {'id': 'https://openalex.org/C169760540', 'wikidata': 'https://www.wikidata.org/wiki/Q207011', 'display_name': 'Neuroscience', 'level': 1, 'score': 0.57777154}, {'id': 'https://openalex.org/C2910823151', 'wikidata': 'https://www.wikidata.org/wiki/Q936818', 'display_name': 'Parabrachial Nucleus', 'level': 3, 'score': 0.55678743}, {'id': 'https://openalex.org/C2779680196', 'wikidata': 'https://www.wikidata.org/wiki/Q410857', 'display_name': 'Orexin', 'level': 4, 'score': 0.5534459}, {'id': 'https://openalex.org/C2776378061', 'wikidata': 'https://www.wikidata.org/wiki/Q7317035', 'display_name': 'Retrograde tracing', 'level': 3, 'score': 0.539908}, {'id': 'https://openalex.org/C32610206', 'wikidata': 'https://www.wikidata.org/wiki/Q5298804', 'display_name': 'Dorsal raphe nucleus', 'level': 5, 'score': 0.5234184}, {'id': 'https://openalex.org/C2780948874', 'wikidata': 'https://www.wikidata.org/wiki/Q640562', 'display_name': 'Ventral tegmental area', 'level': 4, 'score': 0.51301473}, {'id': 'https://openalex.org/C2491326', 'wikidata': 'https://www.wikidata.org/wiki/Q5377024', 'display_name': 'Energy homeostasis', 'level': 3, 'score': 0.5036418}, {'id': 'https://openalex.org/C2777820223', 'wikidata': 'https://www.wikidata.org/wiki/Q936818', 'display_name': 'Lateral parabrachial nucleus', 'level': 4, 'score': 0.49406055}, {'id': 'https://openalex.org/C2777003273', 'wikidata': 'https://www.wikidata.org/wiki/Q164386', 'display_name': 'Hypothalamus', 'level': 2, 'score': 0.48698983}, {'id': 'https://openalex.org/C2776552330', 'wikidata': 'https://www.wikidata.org/wiki/Q1476178', 'display_name': 'Nucleus accumbens', 'level': 3, 'score': 0.47033864}, {'id': 'https://openalex.org/C2778458369', 'wikidata': 'https://www.wikidata.org/wiki/Q253246', 'display_name': 'Arcuate nucleus', 'level': 3, 'score': 0.44876456}, {'id': 'https://openalex.org/C2780714764', 'wikidata': 'https://www.wikidata.org/wiki/Q17125841', 'display_name': 'Lateral hypothalamus', 'level': 3, 'score': 0.4319644}, {'id': 'https://openalex.org/C43295716', 'wikidata': 'https://www.wikidata.org/wiki/Q21118676', 'display_name': 'Melanocortin 4 receptor', 'level': 4, 'score': 0.41903493}, {'id': 'https://openalex.org/C2780723820', 'wikidata': 'https://www.wikidata.org/wiki/Q1934178', 'display_name': 'Nucleus', 'level': 2, 'score': 0.3664549}, {'id': 'https://openalex.org/C2779993316', 'wikidata': 'https://www.wikidata.org/wiki/Q6591465', 'display_name': 'Melanocortin', 'level': 3, 'score': 0.3608466}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.35071903}, {'id': 'https://openalex.org/C118303440', 'wikidata': 'https://www.wikidata.org/wiki/Q419968', 'display_name': 'Neuropeptide', 'level': 3, 'score': 0.32440302}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.3183316}, {'id': 'https://openalex.org/C529278444', 'wikidata': 'https://www.wikidata.org/wiki/Q47273', 'display_name': 'Central nervous system', 'level': 2, 'score': 0.22357446}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.22117403}, {'id': 'https://openalex.org/C513476851', 'wikidata': 'https://www.wikidata.org/wiki/Q170304', 'display_name': 'Dopamine', 'level': 2, 'score': 0.11648309}, {'id': 'https://openalex.org/C137183658', 'wikidata': 'https://www.wikidata.org/wiki/Q461076', 'display_name': 'Dopaminergic', 'level': 3, 'score': 0.09964651}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.0}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C71315377', 'wikidata': 'https://www.wikidata.org/wiki/Q11364', 'display_name': 'Hormone', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C37000724', 'wikidata': 'https://www.wikidata.org/wiki/Q50430226', 'display_name': 'Serotonergic', 'level': 4, 'score': 0.0}, {'id': 'https://openalex.org/C2775864247', 'wikidata': 'https://www.wikidata.org/wiki/Q167934', 'display_name': 'Serotonin', 'level': 3, 'score': 0.0}, {'id': 'https://openalex.org/C511355011', 'wikidata': 'https://www.wikidata.org/wiki/Q12174', 'display_name': 'Obesity', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D007026', 'descriptor_name': 'Hypothalamic Area, Lateral', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': True}, {'descriptor_ui': 'D007026', 'descriptor_name': 'Hypothalamic Area, Lateral', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D009434', 'descriptor_name': 'Neural Pathways', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D009445', 'descriptor_name': 'Neuroanatomy', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D009474', 'descriptor_name': 'Neurons', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D044105', 'descriptor_name': 'Receptor, Melanocortin, Type 4', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002135', 'descriptor_name': 'Calcium-Binding Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D002135', 'descriptor_name': 'Calcium-Binding Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002452', 'descriptor_name': 'Cell Count', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002772', 'descriptor_name': 'Cholera Toxin', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D002772', 'descriptor_name': 'Cholera Toxin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002940', 'descriptor_name': 'Circadian Rhythm', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D002940', 'descriptor_name': 'Circadian Rhythm', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004268', 'descriptor_name': 'DNA-Binding Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D004268', 'descriptor_name': 'DNA-Binding Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D049452', 'descriptor_name': 'Green Fluorescent Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D049452', 'descriptor_name': 'Green Fluorescent Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007026', 'descriptor_name': 'Hypothalamic Area, Lateral', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D047908', 'descriptor_name': 'Intracellular Signaling Peptides and Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D047908', 'descriptor_name': 'Intracellular Signaling Peptides and Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020738', 'descriptor_name': 'Leptin', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D020738', 'descriptor_name': 'Leptin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008564', 'descriptor_name': 'Membrane Potentials', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D008564', 'descriptor_name': 'Membrane Potentials', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D008564', 'descriptor_name': 'Membrane Potentials', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008810', 'descriptor_name': 'Mice, Inbred C57BL', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008822', 'descriptor_name': 'Mice, Transgenic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009419', 'descriptor_name': 'Nerve Tissue Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D009419', 'descriptor_name': 'Nerve Tissue Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009434', 'descriptor_name': 'Neural Pathways', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009474', 'descriptor_name': 'Neurons', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D009474', 'descriptor_name': 'Neurons', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009479', 'descriptor_name': 'Neuropeptides', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D009479', 'descriptor_name': 'Neuropeptides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000080866', 'descriptor_name': 'Nucleobindins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000068797', 'descriptor_name': 'Orexins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016760', 'descriptor_name': 'Proto-Oncogene Proteins c-fos', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D016760', 'descriptor_name': 'Proto-Oncogene Proteins c-fos', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012333', 'descriptor_name': 'RNA, Messenger', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D012333', 'descriptor_name': 'RNA, Messenger', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D044105', 'descriptor_name': 'Receptor, Melanocortin, Type 4', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D044105', 'descriptor_name': 'Receptor, Melanocortin, Type 4', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D050796', 'descriptor_name': 'STAT3 Transcription Factor', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D050796', 'descriptor_name': 'STAT3 Transcription Factor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013266', 'descriptor_name': 'Stilbamidines', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D013266', 'descriptor_name': 'Stilbamidines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1002/cne.23145', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4210186231', 'display_name': 'The Journal of Comparative Neurology', 'issn_l': '0021-9967', 'issn': ['0021-9967', '1096-9861'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc3652326', 'pdf_url': 'https://europepmc.org/articles/pmc3652326?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3652326', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/22605619', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc3652326', 'pdf_url': 'https://europepmc.org/articles/pmc3652326?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, 'sustainable_development_goals': [{'display_name': 'Affordable and clean energy', 'id': 'https://metadata.un.org/sdg/7', 'score': 0.45}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 91, 'referenced_works': ['https://openalex.org/W1260067689', 'https://openalex.org/W1532178599', 'https://openalex.org/W1546146845', 'https://openalex.org/W1561443084', 'https://openalex.org/W1572502886', 'https://openalex.org/W1593075597', 'https://openalex.org/W1597982565', 'https://openalex.org/W1600928508', 'https://openalex.org/W1886595681', 'https://openalex.org/W1942962897', 'https://openalex.org/W1968864595', 'https://openalex.org/W1969835310', 'https://openalex.org/W1974694916', 'https://openalex.org/W1975062397', 'https://openalex.org/W1980492819', 'https://openalex.org/W1981025527', 'https://openalex.org/W1984548515', 'https://openalex.org/W1988909797', 'https://openalex.org/W1989318246', 'https://openalex.org/W1989883434', 'https://openalex.org/W1991021245', 'https://openalex.org/W1994233462', 'https://openalex.org/W1994316641', 'https://openalex.org/W1996713062', 'https://openalex.org/W1999275814', 'https://openalex.org/W2001980298', 'https://openalex.org/W2002936258', 'https://openalex.org/W2007387523', 'https://openalex.org/W2007631899', 'https://openalex.org/W2009189044', 'https://openalex.org/W2009945635', 'https://openalex.org/W2011520421', 'https://openalex.org/W2012000898', 'https://openalex.org/W2012496594', 'https://openalex.org/W2016261339', 'https://openalex.org/W2021631954', 'https://openalex.org/W2022366514', 'https://openalex.org/W2022430914', 'https://openalex.org/W2024181253', 'https://openalex.org/W2027252941', 'https://openalex.org/W2033296244', 'https://openalex.org/W2037447899', 'https://openalex.org/W2038406912', 'https://openalex.org/W2045948521', 'https://openalex.org/W2058910991', 'https://openalex.org/W2060140010', 'https://openalex.org/W2061621885', 'https://openalex.org/W2061994623', 'https://openalex.org/W2063008609', 'https://openalex.org/W2064212430', 'https://openalex.org/W2065389660', 'https://openalex.org/W2066101989', 'https://openalex.org/W2073539399', 'https://openalex.org/W2074617349', 'https://openalex.org/W2077889744', 'https://openalex.org/W2079362976', 'https://openalex.org/W2087949440', 'https://openalex.org/W2089656605', 'https://openalex.org/W2091034155', 'https://openalex.org/W2091105538', 'https://openalex.org/W2091359953', 'https://openalex.org/W2093934820', 'https://openalex.org/W2098623033', 'https://openalex.org/W2110005146', 'https://openalex.org/W2110192694', 'https://openalex.org/W2115294869', 'https://openalex.org/W2117374458', 'https://openalex.org/W2121465211', 'https://openalex.org/W2124849301', 'https://openalex.org/W2131877042', 'https://openalex.org/W2132565242', 'https://openalex.org/W2133635537', 'https://openalex.org/W2136634210', 'https://openalex.org/W2139766673', 'https://openalex.org/W2140549760', 'https://openalex.org/W2141060229', 'https://openalex.org/W2143117469', 'https://openalex.org/W2143647203', 'https://openalex.org/W2151672471', 'https://openalex.org/W2153161303', 'https://openalex.org/W2153526806', 'https://openalex.org/W2154387759', 'https://openalex.org/W2156744092', 'https://openalex.org/W2162716270', 'https://openalex.org/W2164894105', 'https://openalex.org/W2168297364', 'https://openalex.org/W2170032365', 'https://openalex.org/W2170668686', 'https://openalex.org/W2414029684', 'https://openalex.org/W4238499560', 'https://openalex.org/W4302435679'], 'related_works': ['https://openalex.org/W2138261993', 'https://openalex.org/W2093424268', 'https://openalex.org/W2088793428', 'https://openalex.org/W2073619582', 'https://openalex.org/W2067142135', 'https://openalex.org/W2057006214', 'https://openalex.org/W2024119874', 'https://openalex.org/W2008021363', 'https://openalex.org/W1990378025', 'https://openalex.org/W1974931068'], 'abstract_inverted_index': {'Abstract': [0], 'The': [1, 14], 'central': [2], 'melanocortin': [3], 'system': [4], 'regulates': [5, 31], 'body': [6, 196], 'energy': [7, 197], 'homeostasis': [8], 'including': [9, 34, 104], 'the': [10, 24, 28, 58, 68, 90, 102, 118, 124, 148, 168, 171, 186], 'melanocortin‐4': [11], 'receptor': [12, 92], '(MC4R).': [13], 'lateral': [15], 'hypothalamic': [16], 'area': [17], '(LHA)': [18], 'receives': [19], 'dense': [20], 'melanocortinergic': [21], 'inputs': [22], 'from': [23], 'arcuate': [25], 'nucleus': [26, 155, 169], 'of': [27, 57, 126, 164, 170, 195], 'hypothalamus': [29], 'and': [30, 39, 75, 108, 157, 160, 174, 188], 'multiple': [32], 'processes': [33], 'food': [35], 'intake,': [36], 'reward': [37], 'behaviors,': [38], 'autonomic': [40], 'function.': [41], 'By': [42], 'using': [43], 'a': [44], 'mouse': [45], 'line': [46], 'in': [47, 67, 101, 130, 185, 192], 'which': [48], 'green': [49], 'fluorescent': [50], 'protein': [51], '(GFP)': [52], 'is': [53], 'expressed': [54], 'under': [55], 'control': [56], 'MC4R': [59, 65, 119, 183], 'gene': [60], 'promoter,': [61], 'we': [62], 'systemically': [63], 'investigated': [64], 'signaling': [66, 184], 'LHA': [69, 82, 103, 127, 141, 187], 'by': [70], 'combining': [71], 'double': [72], 'immunohistochemistry,': [73], 'electrophysiology,': [74], 'retrograde': [76], 'tracing': [77, 138], 'techniques.': [78], 'We': [79], 'found': [80, 100], 'that': [81, 114, 140], 'MC4R‐GFP': [83, 128, 142], 'neurons': [84, 129, 143, 165], 'coexpress': [85, 96], 'neurotensin': [86], 'as': [87, 89], 'well': [88], 'leptin': [91], 'but': [93, 116], 'do': [94, 144], 'not': [95, 117, 145], 'other': [97], 'peptide': [98], 'neurotransmitters': [99], 'orexin,': [105], 'melanin‐concentrating': [106], 'hormone,': [107], 'nesfatin‐1.': [109], 'Furthermore,': [110], 'electrophysiological': [111], 'recording': [112], 'demonstrated': [113], 'leptin,': [115], 'agonist': [120], 'melanotan': [121], 'II,': [122], 'hyperpolarizes': [123], 'majority': [125], 'an': [131], 'ATP‐': [132], 'sensitive': [133], 'potassium': [134], 'channel–dependent': [135], 'manner.': [136], 'Retrograde': [137], 'revealed': [139], 'project': [146, 166], 'to': [147, 167], 'ventral': [149], 'tegmental': [150], 'area,': [151], 'dorsal': [152], 'raphe': [153], 'nucleus,': [154], 'accumbens,': [156], 'spinal': [158], 'cord,': [159], 'only': [161], 'limited': [162], 'number': [163], 'solitary': [172], 'tract': [173], 'parabrachial': [175], 'nucleus.': [176], 'Our': [177], 'findings': [178], 'provide': [179], 'new': [180], 'insights': [181], 'into': [182], 'its': [189], 'potential': [190], 'implications': [191], 'homeostatic': [193], 'regulation': [194], 'balance.': [198], 'J.': [199], 'Comp.': [200], 'Neurol.': [201], '4168–4183,': [202], '2012.': [203], '©': [204], '2012': [205], 'Wiley': [206], 'Periodcicals,': [207], 'Inc.': [208]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2094640076', 'counts_by_year': [{'year': 2024, 'cited_by_count': 4}, {'year': 2023, 'cited_by_count': 4}, {'year': 2022, 'cited_by_count': 6}, {'year': 2021, 'cited_by_count': 5}, {'year': 2020, 'cited_by_count': 4}, {'year': 2019, 'cited_by_count': 4}, {'year': 2018, 'cited_by_count': 8}, {'year': 2017, 'cited_by_count': 6}, {'year': 2016, 'cited_by_count': 8}, {'year': 2015, 'cited_by_count': 15}, {'year': 2014, 'cited_by_count': 4}, {'year': 2013, 'cited_by_count': 5}, {'year': 2012, 'cited_by_count': 1}], 'updated_date': '2024-09-01T03:44:24.357433', 'created_date': '2016-06-24'}