Publication Information

{'id': 'https://openalex.org/W2094267710', 'doi': 'https://doi.org/10.1073/pnas.1222808110', 'title': '<i>NLRP1</i> haplotypes associated with vitiligo and autoimmunity increase interleukin-1β processing via the NLRP1 inflammasome', 'display_name': '<i>NLRP1</i> haplotypes associated with vitiligo and autoimmunity increase interleukin-1β processing via the NLRP1 inflammasome', 'publication_year': 2013, 'publication_date': '2013-02-04', 'ids': {'openalex': 'https://openalex.org/W2094267710', 'doi': 'https://doi.org/10.1073/pnas.1222808110', 'mag': '2094267710', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/23382179', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/3581876'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1073/pnas.1222808110', 'pdf_url': 'https://www.pnas.org/content/pnas/110/8/2952.full.pdf', 'source': {'id': 'https://openalex.org/S125754415', 'display_name': 'Proceedings of the National Academy of Sciences', 'issn_l': '0027-8424', 'issn': ['0027-8424', '1091-6490'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320052', 'host_organization_name': 'National Academy of Sciences', 'host_organization_lineage': ['https://openalex.org/P4310320052'], 'host_organization_lineage_names': ['National Academy of Sciences'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://www.pnas.org/content/pnas/110/8/2952.full.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5023326797', 'display_name': 'Cecilia B. Levandowski', 'orcid': 'https://orcid.org/0000-0001-6809-4048'}, 'institutions': [{'id': 'https://openalex.org/I921990950', 'display_name': 'University of Colorado Denver', 'ror': 'https://ror.org/02hh7en24', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I921990950']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Cecilia B. Levandowski', 'raw_affiliation_strings': ['Human Medical Genetics and Genomics Program, University of Colorado School of Medicine, Aurora, CO 80045, USA.'], 'affiliations': [{'raw_affiliation_string': 'Human Medical Genetics and Genomics Program, University of Colorado School of Medicine, Aurora, CO 80045, USA.', 'institution_ids': ['https://openalex.org/I921990950']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5009539122', 'display_name': 'Christina M. Mailloux', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210118410', 'display_name': 'Institut thématique Génétique, génomique et bioinformatique', 'ror': 'https://ror.org/01rfstj90', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I154526488', 'https://openalex.org/I4210118410']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Christina M. Mailloux', 'raw_affiliation_strings': ['aHuman Medical Genetics and Genomics Program and'], 'affiliations': [{'raw_affiliation_string': 'aHuman Medical Genetics and Genomics Program and', 'institution_ids': ['https://openalex.org/I4210118410']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5016200361', 'display_name': 'Tracey M. Ferrara', 'orcid': 'https://orcid.org/0000-0001-9599-413X'}, 'institutions': [{'id': 'https://openalex.org/I4210118410', 'display_name': 'Institut thématique Génétique, génomique et bioinformatique', 'ror': 'https://ror.org/01rfstj90', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I154526488', 'https://openalex.org/I4210118410']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Tracey M. Ferrara', 'raw_affiliation_strings': ['aHuman Medical Genetics and Genomics Program and'], 'affiliations': [{'raw_affiliation_string': 'aHuman Medical Genetics and Genomics Program and', 'institution_ids': ['https://openalex.org/I4210118410']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5090028463', 'display_name': 'Katherine Gowan', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210118410', 'display_name': 'Institut thématique Génétique, génomique et bioinformatique', 'ror': 'https://ror.org/01rfstj90', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I154526488', 'https://openalex.org/I4210118410']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Katherine Gowan', 'raw_affiliation_strings': ['aHuman Medical Genetics and Genomics Program and'], 'affiliations': [{'raw_affiliation_string': 'aHuman Medical Genetics and Genomics Program and', 'institution_ids': ['https://openalex.org/I4210118410']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5006101420', 'display_name': 'Songtao Ben', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210118410', 'display_name': 'Institut thématique Génétique, génomique et bioinformatique', 'ror': 'https://ror.org/01rfstj90', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I154526488', 'https://openalex.org/I4210118410']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Songtao Ben', 'raw_affiliation_strings': ['aHuman Medical Genetics and Genomics Program and'], 'affiliations': [{'raw_affiliation_string': 'aHuman Medical Genetics and Genomics Program and', 'institution_ids': ['https://openalex.org/I4210118410']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101549892', 'display_name': 'Ying Jin', 'orcid': 'https://orcid.org/0000-0001-5681-9339'}, 'institutions': [{'id': 'https://openalex.org/I4210118410', 'display_name': 'Institut thématique Génétique, génomique et bioinformatique', 'ror': 'https://ror.org/01rfstj90', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I154526488', 'https://openalex.org/I4210118410']}, {'id': 'https://openalex.org/I921990950', 'display_name': 'University of Colorado Denver', 'ror': 'https://ror.org/02hh7en24', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I921990950']}], 'countries': ['FR', 'US'], 'is_corresponding': False, 'raw_author_name': 'Ying Jin', 'raw_affiliation_strings': ['Human Medical Genetics and Genomics Program and', 'bDepartment of Pediatrics, University of Colorado School of Medicine, Aurora, CO 80045;'], 'affiliations': [{'raw_affiliation_string': 'Human Medical Genetics and Genomics Program and', 'institution_ids': ['https://openalex.org/I4210118410']}, {'raw_affiliation_string': 'bDepartment of Pediatrics, University of Colorado School of Medicine, Aurora, CO 80045;', 'institution_ids': ['https://openalex.org/I921990950']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5068331457', 'display_name': 'Kimberly K. McFann', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I151808059', 'display_name': 'Colorado School of Public Health', 'ror': 'https://ror.org/005x9g035', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I151808059']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Kimberly K. McFann', 'raw_affiliation_strings': ['cColorado Biostatistics Consortium, Colorado School of Public Health, Aurora, CO 80045; and'], 'affiliations': [{'raw_affiliation_string': 'cColorado Biostatistics Consortium, Colorado School of Public Health, Aurora, CO 80045; and', 'institution_ids': ['https://openalex.org/I151808059']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5033101590', 'display_name': 'Paulene J. Holland', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210118410', 'display_name': 'Institut thématique Génétique, génomique et bioinformatique', 'ror': 'https://ror.org/01rfstj90', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I154526488', 'https://openalex.org/I4210118410']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Paulene J. Holland', 'raw_affiliation_strings': ['aHuman Medical Genetics and Genomics Program and'], 'affiliations': [{'raw_affiliation_string': 'aHuman Medical Genetics and Genomics Program and', 'institution_ids': ['https://openalex.org/I4210118410']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5111969333', 'display_name': 'Pamela R. Fain', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210118410', 'display_name': 'Institut thématique Génétique, génomique et bioinformatique', 'ror': 'https://ror.org/01rfstj90', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I154526488', 'https://openalex.org/I4210118410']}, {'id': 'https://openalex.org/I921990950', 'display_name': 'University of Colorado Denver', 'ror': 'https://ror.org/02hh7en24', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I921990950']}, {'id': 'https://openalex.org/I2799803081', 'display_name': 'Diabetes Australia', 'ror': 'https://ror.org/008aaf926', 'country_code': 'AU', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I2799803081']}], 'countries': ['AU', 'FR', 'US'], 'is_corresponding': False, 'raw_author_name': 'Pamela R. Fain', 'raw_affiliation_strings': ['Barbara Davis Center for Childhood Diabetes, and', 'Human Medical Genetics and Genomics Program and', 'bDepartment of Pediatrics, University of Colorado School of Medicine, Aurora, CO 80045;'], 'affiliations': [{'raw_affiliation_string': 'Human Medical Genetics and Genomics Program and', 'institution_ids': ['https://openalex.org/I4210118410']}, {'raw_affiliation_string': 'bDepartment of Pediatrics, University of Colorado School of Medicine, Aurora, CO 80045;', 'institution_ids': ['https://openalex.org/I921990950']}, {'raw_affiliation_string': 'Barbara Davis Center for Childhood Diabetes, and', 'institution_ids': ['https://openalex.org/I2799803081']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5028234430', 'display_name': 'Charles A. Dinarello', 'orcid': 'https://orcid.org/0000-0002-5073-8316'}, 'institutions': [{'id': 'https://openalex.org/I921990950', 'display_name': 'University of Colorado Denver', 'ror': 'https://ror.org/02hh7en24', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I921990950']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Charles A. Dinarello', 'raw_affiliation_strings': ['eDepartment of Medicine, University of Colorado School of Medicine, Aurora, CO 80045;'], 'affiliations': [{'raw_affiliation_string': 'eDepartment of Medicine, University of Colorado School of Medicine, Aurora, CO 80045;', 'institution_ids': ['https://openalex.org/I921990950']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5079793510', 'display_name': 'Richard A. Spritz', 'orcid': 'https://orcid.org/0000-0002-8325-0026'}, 'institutions': [{'id': 'https://openalex.org/I4210118410', 'display_name': 'Institut thématique Génétique, génomique et bioinformatique', 'ror': 'https://ror.org/01rfstj90', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I154526488', 'https://openalex.org/I4210118410']}, {'id': 'https://openalex.org/I921990950', 'display_name': 'University of Colorado Denver', 'ror': 'https://ror.org/02hh7en24', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I921990950']}], 'countries': ['FR', 'US'], 'is_corresponding': False, 'raw_author_name': 'Richard A. Spritz', 'raw_affiliation_strings': ['Human Medical Genetics and Genomics Program and', 'bDepartment of Pediatrics, University of Colorado School of Medicine, Aurora, CO 80045;'], 'affiliations': [{'raw_affiliation_string': 'Human Medical Genetics and Genomics Program and', 'institution_ids': ['https://openalex.org/I4210118410']}, {'raw_affiliation_string': 'bDepartment of Pediatrics, University of Colorado School of Medicine, Aurora, CO 80045;', 'institution_ids': ['https://openalex.org/I921990950']}]}], 'institution_assertions': [], 'countries_distinct_count': 3, 'institutions_distinct_count': 4, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 7.092, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 198, 'citation_normalized_percentile': {'value': 0.999985, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '110', 'issue': '8', 'first_page': '2952', 'last_page': '2956'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11078', 'display_name': 'Inflammasome and immune disorders', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11078', 'display_name': 'Inflammasome and immune disorders', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12955', 'display_name': 'Atherosclerosis and Cardiovascular Diseases', 'score': 0.9939, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12528', 'display_name': 'IL-33, ST2, and ILC Pathways', 'score': 0.9829, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/aim2', 'display_name': 'AIM2', 'score': 0.41767457}], 'concepts': [{'id': 'https://openalex.org/C197754878', 'wikidata': 'https://www.wikidata.org/wiki/Q80711', 'display_name': 'Haplotype', 'level': 4, 'score': 0.7088623}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.6865841}, {'id': 'https://openalex.org/C2777209026', 'wikidata': 'https://www.wikidata.org/wiki/Q412405', 'display_name': 'Inflammasome', 'level': 3, 'score': 0.67408186}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.56025404}, {'id': 'https://openalex.org/C136449434', 'wikidata': 'https://www.wikidata.org/wiki/Q428253', 'display_name': 'Innate immune system', 'level': 3, 'score': 0.50724643}, {'id': 'https://openalex.org/C2780130043', 'wikidata': 'https://www.wikidata.org/wiki/Q192360', 'display_name': 'Autoimmunity', 'level': 3, 'score': 0.4537159}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.4363727}, {'id': 'https://openalex.org/C187831198', 'wikidata': 'https://www.wikidata.org/wiki/Q18034187', 'display_name': 'AIM2', 'level': 4, 'score': 0.41767457}, {'id': 'https://openalex.org/C8891405', 'wikidata': 'https://www.wikidata.org/wiki/Q1059', 'display_name': 'Immune system', 'level': 2, 'score': 0.2941449}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.24275231}, {'id': 'https://openalex.org/C180754005', 'wikidata': 'https://www.wikidata.org/wiki/Q80726', 'display_name': 'Allele', 'level': 3, 'score': 0.20502904}, {'id': 'https://openalex.org/C2776914184', 'wikidata': 'https://www.wikidata.org/wiki/Q101991', 'display_name': 'Inflammation', 'level': 2, 'score': 0.20364922}], 'mesh': [{'descriptor_ui': 'D048868', 'descriptor_name': 'Adaptor Proteins, Signal Transducing', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D051017', 'descriptor_name': 'Apoptosis Regulatory Proteins', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D015551', 'descriptor_name': 'Autoimmunity', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D006239', 'descriptor_name': 'Haplotypes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D058847', 'descriptor_name': 'Inflammasomes', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D053583', 'descriptor_name': 'Interleukin-1beta', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D014820', 'descriptor_name': 'Vitiligo', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D048868', 'descriptor_name': 'Adaptor Proteins, Signal Transducing', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D048868', 'descriptor_name': 'Adaptor Proteins, Signal Transducing', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051017', 'descriptor_name': 'Apoptosis Regulatory Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051017', 'descriptor_name': 'Apoptosis Regulatory Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D015551', 'descriptor_name': 'Autoimmunity', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D058847', 'descriptor_name': 'Inflammasomes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D053583', 'descriptor_name': 'Interleukin-1beta', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009000', 'descriptor_name': 'Monocytes', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D009000', 'descriptor_name': 'Monocytes', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D009000', 'descriptor_name': 'Monocytes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014820', 'descriptor_name': 'Vitiligo', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1073/pnas.1222808110', 'pdf_url': 'https://www.pnas.org/content/pnas/110/8/2952.full.pdf', 'source': {'id': 'https://openalex.org/S125754415', 'display_name': 'Proceedings of the National Academy of Sciences', 'issn_l': '0027-8424', 'issn': ['0027-8424', '1091-6490'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320052', 'host_organization_name': 'National Academy of Sciences', 'host_organization_lineage': ['https://openalex.org/P4310320052'], 'host_organization_lineage_names': ['National Academy of Sciences'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc3581876', 'pdf_url': 'https://europepmc.org/articles/pmc3581876?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3581876', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/23382179', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1073/pnas.1222808110', 'pdf_url': 'https://www.pnas.org/content/pnas/110/8/2952.full.pdf', 'source': {'id': 'https://openalex.org/S125754415', 'display_name': 'Proceedings of the National Academy of Sciences', 'issn_l': '0027-8424', 'issn': ['0027-8424', '1091-6490'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320052', 'host_organization_name': 'National Academy of Sciences', 'host_organization_lineage': ['https://openalex.org/P4310320052'], 'host_organization_lineage_names': ['National Academy of Sciences'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'score': 0.83, 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 33, 'referenced_works': ['https://openalex.org/W1522588191', 'https://openalex.org/W1535399883', 'https://openalex.org/W1825259197', 'https://openalex.org/W1973329998', 'https://openalex.org/W1974687506', 'https://openalex.org/W1987946536', 'https://openalex.org/W1993808715', 'https://openalex.org/W1998425748', 'https://openalex.org/W2005373844', 'https://openalex.org/W2016193783', 'https://openalex.org/W2023706277', 'https://openalex.org/W2027622905', 'https://openalex.org/W2029781663', 'https://openalex.org/W2035185255', 'https://openalex.org/W2035315634', 'https://openalex.org/W2041624512', 'https://openalex.org/W2043091577', 'https://openalex.org/W2047652054', 'https://openalex.org/W2064909561', 'https://openalex.org/W2073216707', 'https://openalex.org/W2074079489', 'https://openalex.org/W2078169669', 'https://openalex.org/W2096259698', 'https://openalex.org/W2099808663', 'https://openalex.org/W2108373994', 'https://openalex.org/W2110348886', 'https://openalex.org/W2115381033', 'https://openalex.org/W2128190429', 'https://openalex.org/W2129656393', 'https://openalex.org/W2134735862', 'https://openalex.org/W2150107812', 'https://openalex.org/W2151071984', 'https://openalex.org/W4210840215'], 'related_works': ['https://openalex.org/W4308148810', 'https://openalex.org/W4214660895', 'https://openalex.org/W3040807962', 'https://openalex.org/W2981249357', 'https://openalex.org/W2930972727', 'https://openalex.org/W2738358378', 'https://openalex.org/W2103200355', 'https://openalex.org/W2063946975', 'https://openalex.org/W2027470036', 'https://openalex.org/W1925782076'], 'abstract_inverted_index': {'Nuclear': [0], 'localization': [1], 'leucine-rich-repeat': [2], 'protein': [3, 229], '1': [4, 66], '(NLRP1)': [5], 'is': [6, 51], 'a': [7, 75, 215], 'key': [8], 'regulator': [9], 'of': [10, 38, 56, 77, 156, 243, 255], 'the': [11, 17, 32, 99, 130, 144, 157, 186, 206, 235, 244, 256], 'innate': [12], 'immune': [13], 'system,': [14], 'particularly': [15], 'in': [16, 20, 43, 79, 88, 91, 169, 192, 198], 'skin': [18], 'where,': [19], 'response': [21, 170], 'to': [22, 125, 160, 171, 250], 'molecular': [23, 30], 'triggers': [24], 'such': [25], 'as': [26], 'pathogen-associated': [27], 'or': [28, 224], 'damage-associated': [29], 'patterns,': [31], 'NLRP1': [33, 50, 80, 89, 226, 247, 257], 'inflammasome': [34], 'promotes': [35], 'caspase-1-dependent': [36], 'processing': [37], 'bioactive': [39, 162], 'interleukin-1β': [40], '(IL-1β),': [41], 'resulting': [42], 'IL-1β': [44, 158, 163], 'secretion': [45], 'and': [46, 70, 117, 119, 168, 177, 202, 228], 'downstream': [47], 'inflammatory': [48], 'responses.': [49], 'genetically': [52], 'associated': [53], 'with': [54, 180], 'risk': [55, 110], 'several': [57, 92], 'autoimmune': [58, 251], 'diseases': [59, 252], 'including': [60], 'generalized': [61], 'vitiligo,': [62], 'Addison': [63], 'disease,': [64], 'type': [65], 'diabetes,': [67], 'rheumatoid': [68], 'arthritis,': [69], 'others.': [71], 'Here': [72], 'we': [73, 133], 'identify': [74], 'repertoire': [76], 'variation': [78], 'by': [81, 101, 234, 253], 'deep': [82], 'DNA': [83], 'resequencing.': [84], 'Predicted': [85], 'functional': [86], 'variations': [87], 'reside': [90], 'common': [93], 'high-risk': [94, 146, 237], 'haplotypes': [95, 106, 208], 'that': [96, 107, 135, 240], 'differ': [97], 'from': [98, 139, 182], 'reference': [100, 187], 'multiple': [102], 'nonsynonymous': [103], 'substitutions.': [104], 'The': [105, 190], 'are': [108, 120], 'high': [109], 'for': [111, 143, 185, 222], 'disease': [112], 'share': [113], 'two': [114, 207], 'substitutions,': [115], 'L155H': [116], 'M1184V,': [118], 'inherited': [121], 'largely': [122], 'intact': [123], 'due': [124], 'extensive': [126], 'linkage': [127], 'disequilibrium': [128], 'across': [129], 'region.': [131], 'Functionally,': [132], 'found': [134], 'peripheral': [136], 'blood': [137], 'monocytes': [138, 181], 'healthy': [140], 'subjects': [141, 183], 'homozygous': [142, 184], 'predominant': [145, 236], 'haplotype': [147, 188, 199], '2A': [148, 200], 'processed': [149], 'significantly': [150], 'greater': [151, 197], '(P': [152], '<': [153], '0.0001)': [154], 'amounts': [155], 'precursor': [159], 'mature': [161], 'under': [164], 'basal': [165, 193], '(resting)': [166], 'conditions': [167], 'Toll-like': [172], 'receptor': [173], '(TLR)': [174], 'agonists': [175], '(TLR2': [176], 'TLR4)': [178], 'compared': [179], '1.': [189], 'increase': [191], 'release': [194], 'was': [195], '1.8-fold': [196], 'monocytes,': [201], 'these': [203], 'differences': [204, 219], 'between': [205], 'were': [209, 220, 231], 'consistently': [210], 'observed': [211, 221], 'three': [212], 'times': [213], 'over': [214], '3-mo': [216], 'period;': [217], 'no': [218], 'IL-1α': [223], 'TNFα.': [225], 'RNA': [227], 'levels': [230], 'not': [232], 'altered': [233, 241], 'haplotype,': [238], 'indicating': [239], 'function': [242], 'corresponding': [245], 'multivariant': [246], 'polypeptide': [248], 'predisposes': [249], 'activation': [254], 'inflammasome.': [258]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2094267710', 'counts_by_year': [{'year': 2024, 'cited_by_count': 13}, {'year': 2023, 'cited_by_count': 15}, {'year': 2022, 'cited_by_count': 23}, {'year': 2021, 'cited_by_count': 22}, {'year': 2020, 'cited_by_count': 25}, {'year': 2019, 'cited_by_count': 12}, {'year': 2018, 'cited_by_count': 14}, {'year': 2017, 'cited_by_count': 17}, {'year': 2016, 'cited_by_count': 11}, {'year': 2015, 'cited_by_count': 18}, {'year': 2014, 'cited_by_count': 17}, {'year': 2013, 'cited_by_count': 10}], 'updated_date': '2024-12-20T17:55:47.534859', 'created_date': '2016-06-24'}