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362, 383, 409, 435, 456], 'by': [60, 81, 102, 123, 144, 165, 191, 217, 238, 279, 300, 321, 342, 363, 384, 410, 436, 457, 575, 1122, 1205, 1238, 1435, 1484, 1490, 1632, 1784, 2620], 'this': [61, 82, 103, 124, 145, 166, 192, 218, 239, 280, 301, 322, 343, 364, 385, 411, 437, 458, 521, 811, 2094], 'authorHideto': [62, 281], 'Yamada,': [63, 282, 3365], 'Hideto': [64, 283], 'Yamada': [65, 284], 'JapanSearch': [77, 98, 119, 140, 161, 187, 213, 234, 296, 317, 338, 359, 380, 406, 432, 453], 'authorTakafumi': [83, 302], 'Fujino,': [84, 303], 'Takafumi': [85, 304], 'Fujino': [86, 305], 'authorItsuko': [104, 323], 'Furuta,': [105, 324], 'Itsuko': [106, 325], 'Furuta': [107, 326], 'authorNoriaki': [125, 344], 'Sakuragi,': [126, 345], 'Noriaki': [127, 346], 'Sakuragi': [128, 347], 'authorRitsu': [146, 365], 'Yamamoto,': [147, 366], 'Ritsu': [148, 367], 'Yamamoto': [149, 368], 'authorMotonobu': [167, 386], 'Katoh,': [168, 387], 'Motonobu': [169, 388], 'Katoh': [170, 389], 'Molecular': [173, 199, 392, 418], 'Cell': [175, 201, 394, 420], 'Genetics,': [176, 202, 395, 421], 'Tottori': [177, 203, 396, 422], 'Faculty': [179, 205, 398, 424], 'Life': [184, 210, 403, 429], 'Science,': [185, 211, 404, 430, 3286], 'Yonago,': [186, 212, 405, 431], 'authorMitsuo': [193, 412], 'Oshimura,': [194, 413], 'Mitsuo': [195, 414], 'Oshimura': [196, 415], 'authorSeiichiro': [219, 438], 'Fujimoto,': [220, 439], 'Seiichiro': [221, 440], 'Fujimoto': [222, 441], 'author': [240, 459], 'First': [460], 'published:': [461], '10': [462, 1286, 1542, 1875, 1940, 1948, 2244, 2256, 2269], 'November': [463], '1999': [464, 679], 'https://doi.org/10.1002/(SICI)1097-0215(19991022)84:5<529::AID-IJC15>3.0.CO;2-JCitations:': [465], '13AboutSectionsPDF': [466], 'ToolsRequest': [467], 'permissionExport': [468], 'citationAdd': [469], 'to': [470, 492, 515, 551, 556, 566, 687, 702, 708, 728, 757, 796, 855, 870, 903, 966, 1056, 1179, 1195, 1220, 1234, 1250, 1445, 1535, 1627, 1740, 1855, 2040, 2089, 2173, 2180, 2478, 2482], 'favoritesTrack': [471], 'citation': [472], 'ShareShare': [473], 'Give': [474], 'accessShare': [475, 478], 'full': [476], 'text': [477], 'full-text': [479, 494, 518], 'accessPlease': [480], 'review': [481], 'our': [482, 2825], 'Terms': [483, 506], 'Conditions': [485, 508], 'Use': [487, 948], 'check': [489], 'box': [490], 'below': [491, 514], 'share': [493, 516], 'version': [495, 519], 'article.I': [497], 'have': [498, 664, 938, 1016, 2090, 2616, 2624, 2705, 2726, 2854], 'read': [499], 'accept': [501], 'the': [502, 512, 542, 616, 697, 703, 710, 734, 737, 967, 971, 1002, 1009, 1060, 1115, 1196, 1235, 1252, 1261, 1338, 1350, 1366, 1431, 1504, 1513, 1557, 1560, 1564, 1767, 1773, 1790, 1817, 1841, 1859, 1999, 2041, 2308, 2398, 2403, 2424, 2457, 2465, 2506, 2517, 2581, 2632, 2639, 2686, 2729, 2756, 2864, 2952, 3005, 3056, 3061, 3239, 3389, 3580], 'Wiley': [503], 'Online': [504], 'Library': [505], 'UseShareable': [510], 'LinkUse': [511], 'link': [513], 'a': [517, 532, 579, 665, 762, 772, 779, 784, 798, 953, 1199, 1355, 1519, 1524, 1545, 1655, 1659, 1667, 1763, 1810, 2534], 'article': [522], 'your': [524], 'friends': [525], 'colleagues.': [527], 'Learn': [528], 'more.Copy': [529], 'URL': [530], 'Share': [531], 'linkShare': [533], 'onFacebookTwitterLinkedInRedditWechat': [534], 'Abstract': [535], 'has': [538, 792, 815, 850, 963, 980, 2821, 2841], 'been': [539, 816, 851, 940, 964, 982, 1078, 2822, 2842], 'implicated': [540], 'progression': [543, 658, 2460], 'various': [545], 'human': [546, 2524, 2711, 2828, 3006, 3037, 3064, 3104, 3209, 3278, 3328, 3351, 3385, 3417, 3448, 3521, 3553], 'tumors.': [547, 973, 3106, 3145, 3307], 'Our': [548, 644, 2501], 'aim': [549], 'was': [550, 573, 605, 611, 631, 959, 1118, 1165, 1185, 1211, 1231, 1273, 1340, 1352, 1368, 1443, 1458, 1507, 1528, 1533, 1554, 1592, 1603, 1625, 1652, 1697, 1704, 1715, 1729, 1738, 1747, 1849, 1865, 1994, 2063, 2095, 2352, 2744], 'evaluate': [552], 'telomerase': [553, 597, 618, 629, 651, 790, 813, 848, 922, 950, 978, 1018, 1029, 1161, 1246, 1569, 1671, 1723, 1769, 1782, 1795, 1806, 1823, 1847, 1863, 1986, 2003, 2055, 2061, 2085, 2092, 2324, 2340, 2358, 2374, 2531, 2540, 2552, 2618, 2630, 2655, 2676, 2700, 2739, 2751, 2759, 2804, 2834, 2859, 2912, 2924, 3207, 3279, 3445], 'compare': [557], 'it': [558, 794, 962], 'carcinoma,': [565, 976, 2463, 2755, 2800], 'look': [567], 'possible': [569, 795], 'correlations.': [570], 'measured': [574, 1353], 'dilution': [576, 602, 1006, 1591, 1708, 1786, 1815, 1830, 1834, 1839], 'analysis': [577, 1007, 1121, 1726, 1728, 2622], 'using': [578, 771, 1005, 1124, 1243, 1354, 1541, 1571, 1731, 1956, 1965, 1972, 2277, 2286, 2293], 'PCR-based': [580, 787, 1010], 'telomeric': [581, 766, 1011], 'repeat': [582, 1012, 1226, 1442], 'amplification': [583, 1013, 1227], 'method': [584], 'detected': [586, 599, 817, 852, 1588, 1748, 3137], '31': [588, 1462, 1750, 1791], '35': [590, 1050, 1753, 1950], 'primary': [591, 1044, 1092, 2742, 2762, 2776], 'tumor': [594, 621, 657, 929, 1045, 1189, 1214, 1262, 1565, 1623, 2537, 2813], 'specimens.': [595, 609], 'High': [596], 'activity,': [598, 2093, 2532, 2631], 'after': [600, 1100, 1589, 1694, 1706, 1712, 1813, 1832, 1837], '100-fold': [601, 1590, 1695, 1713, 1814, 1838], 'extracts,': [604], 'identified': [606], '15': [608, 688, 1802, 1953, 2127, 2183, 2313], 'There': [610, 1993], 'no': [612, 1722, 1995, 2651, 2692, 2801, 2831], 'significant': [613, 1852, 1996, 2097], 'correlation': [614, 1981, 1997, 2832], 'between': [615, 921, 1028, 1982, 1998, 2803, 2833, 3525], 'positive': [617, 1668, 1693, 1705, 1764, 1794, 1846, 2002, 2054, 2084, 2738], 'surgical': [622, 636, 1856, 2385, 2873, 2893], 'stage': [623, 637, 930, 1869, 1883, 1911, 2317, 2333, 2817, 2894], 'or': [624, 1083, 1174, 1193, 1201, 1218, 1536, 1831, 1871, 1885, 1958, 1975, 2027, 2279, 2296, 2319, 2335, 2652, 2921], 'factors.': [626, 1033], 'However,': [627, 1858, 2421, 2852], 'high': [628, 1509, 1805, 1862, 1867, 2060, 2065, 2091, 2323, 2339, 2357, 2373, 2858, 2911], 'significantly': [632, 1866, 2064, 2354, 2376, 2772, 2861], 'correlated': [633, 983, 2355, 2377], 'advanced': [635, 2384, 2872, 2892], 'pelvic': [640, 1142, 2018, 2047, 2069, 2379, 2867, 2888], 'lymph': [641, 1143, 1147, 2050, 2070, 2349, 2380, 2732, 2868], 'node': [642, 1144, 1148, 2019, 2022, 2051, 2071, 2225, 2238, 2350, 2381, 2733, 2869, 2889], 'metastasis.': [643], 'findings': [645], 'suggest': [646], 'that': [647, 660, 764, 1511, 1539, 1597, 1881, 2626, 2674, 2728, 2747, 2857, 2899], 'an': [648, 730, 1244, 1683], 'increase': [649], 'may': [653, 663, 2512, 2914], 'be': [654, 1741, 2915], 'associated': [655], 'its': [661, 775, 1531, 2408, 3451], 'level': [662, 2633, 2757], 'prognostic': [666, 954, 987, 2703, 2839], 'value': [667], 'carcinoma.': [670, 1618, 2979, 3244, 3354, 3419], 'Int.': [671, 3492], 'J.': [672, 3040, 3107, 3215, 3246, 3493], 'Cancer': [673, 2980, 3010, 3109, 3146, 3179, 3309, 3330, 3391, 3532], '(Pred.': [674], 'Oncol.)': [675], '84:529–532,': [676], '1999.': [677], '©': [678], 'Wiley-Liss,': [680], 'Inc.': [681], 'Human': [682], 'telomeres': [683, 715, 750, 2544], 'consist': [684], '4': [686, 1919, 1931, 1939, 1951, 2034, 2126, 2151, 2163, 2168, 2177, 2193, 2211, 2216, 2223, 2229, 2242, 2267, 2311], 'kb': [689], 'hexameric': [691], 'DNA': [692, 706, 767, 1256, 1419, 1526, 2815], 'repeats': [693], '(TTAGGG)': [694], 'located': [695], 'at': [696, 1059, 1105, 1271, 1330, 1336, 1344, 1430, 1450, 1465, 1635, 1641, 1646, 2476], 'ends': [698, 711, 725, 739, 770], 'chromosomes.': [700], 'Due': [701], 'inability': [704], 'polymerase': [707, 1257, 1420, 1777], 'replicate': [709], 'double-stranded': [713], 'DNA,': [714], 'progressively': [716], 'shorten': [717], 'each': [719, 1371, 1788], 'round': [720], 'cell': [722, 1549, 1663, 2795, 3353], 'division.': [723], 'Telomeric': [724, 1225, 1441], 'are': [726, 2454, 2895], 'considered': [727, 1186, 1739], 'play': [729], 'important': [731], 'role': [732], 'protection': [735], 'chromosomal': [738, 754, 769], 'against': [740], 'aberrant': [741], 'recombination': [742], 'end': [744], 'fusion.': [745], 'The': [746, 781, 1109, 1346, 1455, 1479, 1501, 1679, 1843, 1980, 2057, 2885], 'progressive': [747], 'shortening': [748], 'eventually': [751], 'results': [752], 'instability,': [755], 'leading': [756], 'cellular': [758], 'senescence.': [759], 'is': [761, 1682, 1988, 2395, 2410, 2473, 2553, 2636, 2691, 2771, 3136], 'ribonucleoprotein': [763], 'synthesizes': [765], 'onto': [768], 'segment': [773], 'RNA': [776], 'component': [777], 'as': [778, 928, 952, 1167, 1508, 1510, 1521, 1594, 1605, 1654, 1666, 1699, 1717, 2415, 2417, 2577, 2810], 'template.': [780], 'development': [782, 2458], 'highly': [785], 'sensitive': [786], 'assay': [788, 1224, 1230, 1358, 1373, 1456, 1506, 1634, 1770], 'made': [793], 'study': [797], 'wide': [799], 'variety': [800], 'tumors': [802, 1792, 1803, 1873, 1887, 2315, 2331, 2743, 2763, 2777], 'normal': [804, 2523, 2550, 2627, 3485], 'tissues': [805, 1023, 1041, 1117, 2575, 3557], '(Kim': [806, 2545], 'et': [807, 825, 833, 842, 862, 866, 877, 882, 886, 890, 894, 898, 909, 913, 917, 944, 990, 994, 998, 1240, 2436, 2440, 2446, 2450, 2486, 2490, 2494, 2498, 2546, 2560, 2568, 2593, 2601, 2605, 2609, 2613, 2658, 2662, 2666, 2670, 2715, 2722, 2782, 2790, 2797, 2845, 2849], 'al.,': [808, 826, 834, 843, 863, 867, 878, 883, 887, 891, 895, 899, 910, 914, 918, 945, 991, 995, 999, 2437, 2441, 2447, 2451, 2487, 2491, 2495, 2499, 2547, 2561, 2569, 2594, 2602, 2606, 2610, 2659, 2663, 2667, 2671, 2716, 2723, 2783, 2791, 2798, 2846, 2850], '1994).': [809, 2548], 'Using': [810], 'method,': [812, 1014], '85%': [819, 828], 'gastric': [821, 934, 2712, 3177], 'carcinomas': [822, 831, 840, 860, 875, 907, 1096, 2830, 2909], '(Hiyama': [823, 841, 942, 2591, 2713, 2720, 2780], 'E.,': [824, 943, 2714, 2721, 2781, 3083, 3116, 3154, 3195, 3512], '1995),': [827], 'hepatocellular': [830, 2788, 3530], '(Tahara': [832, 2789], '1995)': [835, 2595, 2717, 2792], '93%': [837], 'breast': [839, 936, 2719, 3105], '1996).': [844, 947], 'In': [845, 974, 1001, 2549, 2642, 2753, 2785], 'gynecological': [846, 3038, 3306], 'malignancies,': [847], '83%': [854], '100%': [856, 871], 'cervical': [859, 1138, 1547, 1661, 2014], '(Kyo': [861, 876, 908], '1996;': [864, 911], 'Garham': [865, 885, 912], '1997),': [868, 2672], '82%': [869], '1996,': [879], '1997;': [880, 884, 888, 892, 896, 915, 992, 996, 2603, 2607, 2660, 2664, 2668, 2847], 'Brien': [881], 'Saito': [889, 2608, 2665], 'Shroyer': [893, 997, 2669, 2848], 'Yokoyama': [897, 916], '1998)': [900], '86%': [902], '96%': [904], 'ovarian': [906], '1998).': [919], 'Correlations': [920], 'clinico-pathological': [925, 2807], 'such': [927, 2576, 2809], 'grade': [932, 1164, 2136, 2153], 'cancer': [937, 1548, 1662, 2725, 3140, 3456], 'also': [939, 2353], 'described': [941, 1237], '1995,': [946], 'marker': [955], 'clinical': [957, 2819], 'outcome': [958], 'proposed': [960], 'because': [961], 'related': [965], 'malignancy': [968], 'potential': [969, 3452], 'above-mentioned': [972], 'however,': [977], 'never': [981, 1077], '(Brien': [989, 2600, 2657, 2844], 'Kyo': [993, 2604, 2612, 2661], '1997).': [1000, 2611, 2784, 2851], 'present': [1003, 1187], 'study,': [1004], 'we': [1015, 1567, 2853], 'analyzed': [1017, 1631], 'looked': [1025], 'correlations': [1027, 2876], 'MATERIAL': [1034], 'AND': [1035, 1901, 2107], 'METHODS': [1036], 'Tissue': [1037], 'specimens': [1038, 2044, 2079], 'Endometrial': [1039, 2908], 'taken': [1042], 'from': [1043, 1049, 1091, 1622, 1673, 1758, 2032, 2316, 2332, 2647, 2766], 'sites': [1046], 'were': [1047, 1067, 1072, 1097, 1156, 1191, 1216, 1482, 1797, 2037, 2305, 2877, 2883], 'obtained': [1048, 1540, 2764], 'Japanese': [1051], 'patients': [1052, 1065, 1075, 2036, 2067, 2304, 2321, 2337, 2736, 2749, 2767, 2882, 2904], '(age': [1053], 'range': [1054], '23': [1055], '77': [1057], 'years)': [1058], 'time': [1061], 'surgery.': [1063], 'Eleven': [1064], '(31.4%)': [1066], 'pre-menopausal': [1068], '24': [1070], '(68.6%)': [1071], 'post-menopausal.': [1073], 'These': [1074, 2875], 'had': [1076, 1804, 1821, 2083], 'treated': [1079], 'irradiation,': [1081], 'chemotherapy': [1082], 'hormonal': [1084], 'therapy': [1085], 'before': [1086, 1120, 1829], 'tissue': [1087, 1265, 1624], 'sampling.': [1088], 'Specimens': [1089], 'derived': [1090], 'lesions': [1093, 2031], 'frozen': [1098, 1270], 'immediately': [1099], 'sampling': [1101], 'stored': [1103, 1343], 'once': [1104], '−80°C': [1106], 'until': [1107], 'analysis.': [1108], 'presence': [1110, 2865, 2886], 'malignant': [1112], 'cells': [1113, 1190, 1215, 1543, 2526, 2538, 2558, 2566, 2572, 2579, 3283], 'sampled': [1116], 'confirmed': [1119, 2878], 'microscopy,': [1123], 'cryostat': [1125], 'sections.': [1126], 'Histo-pathological': [1127, 2113], 'data,': [1128], 'including': [1129], 'histological': [1130, 1132, 2006, 2008], 'subtype,': [1131, 2007], 'nuclear': [1134, 2010], 'grade,': [1135, 2009, 2011, 2812], 'myometrium': [1136, 2182, 2189], 'invasion,': [1139, 2013, 2015], 'adnexal': [1140, 2016], 'metastasis,': [1141, 1149, 2017, 2020, 2023], 'para-aortic': [1146, 2021, 2049], 'lymph-vascular': [1150, 2024], 'space': [1151, 1183, 1203, 2025, 2251], 'invasion': [1152, 1184, 1210, 2026, 2170, 2195, 2201, 2252], 'extra-uterine': [1154, 2028, 2081], 'disease,': [1155], 'collected': [1157, 1341], 'compared': [1159, 1879], 'activity.': [1162, 1724, 2056, 2752, 2925], 'Histological': [1163, 2121, 2135], 'determined': [1166], 'follows:': [1168], 'well-differentiated': [1169], '(G1),': [1170], 'moderately': [1171], 'differentiated': [1172, 1176], '(G2)': [1173], 'poorly': [1175], '(G3)': [1177], 'according': [1178, 1233], 'FIGO': [1180], 'criteria.': [1181], 'Lymph-vascular': [1182, 2250], 'when': [1188, 1213, 1523, 1878, 2879], 'within': [1192, 1217], 'attached': [1194], 'wall': [1197], 'vascular': [1200], 'lymphatic': [1202], 'lined': [1204], 'flattened': [1206], 'endothelial': [1207], 'cells.': [1208, 1678, 3214, 3559], 'Cervical': [1209, 2200], 'diagnosed': [1212], 'adhered': [1219], 'endocervical': [1221], 'tissue.': [1222], 'protocol': [1228], '(TRAP)': [1229], 'performed': [1232, 1730], 'methods': [1236], 'Kim': [1239], 'al.': [1241, 2614], '(1994),': [1242], 'internal': [1245, 1684, 1768], 'standard': [1248], '(ITAS),': [1249], 'exclude': [1251], 'possibility': [1253, 1774], 'Taq': [1255, 1418, 1776], 'inhibitory': [1258], 'extracts.': [1263], 'Each': [1264, 1619], 'specimen': [1266], '(approx.': [1267], '100': [1268, 1675], 'mg,': [1269], '−80°C)': [1272], 'washed': [1274], 'ice-cold': [1276, 1299], 'buffer': [1277, 1301, 1651], '[10': [1278], 'mM': [1279, 1284, 1287, 1290, 1303, 1308, 1311, 1318, 1321, 1384, 1389, 1392, 1398], 'HEPES-KOH': [1280], '(pH': [1281, 1305, 1386], '7.5),': [1282, 1306], '1.5': [1283, 1388], 'MgCl2,': [1285, 1309, 1390], 'KCl,': [1288, 1393], '1': [1289, 1307, 1310, 1397, 1407, 1922, 1923, 1924, 1933, 1954, 2133, 2134, 2139, 2150, 2154, 2156, 2167, 2176, 2178, 2209, 2235, 2248, 2260, 2275], 'DTT],': [1291], 'pelleted,': [1292], 'then': [1293, 1459], 'sufficiently': [1294], 'homogenized': [1295], '200': [1297], 'ml': [1298], 'lysis': [1300], '[1': [1302], 'Tris-HCl': [1304, 1385], 'EGTA,': [1312, 1399], '60%': [1313], 'glycerol,': [1314], '0.5%': [1315], 'CHAPS,': [1316], '2-mercaptoethanol,': [1319], '0.1': [1320, 1403, 1426], 'AEBSF].': [1322], 'After': [1323, 1779], '30-min': [1324], 'incubation': [1325], 'on': [1326, 3378], 'ice': [1327], 'centrifugation': [1329], '16,000': [1331], 'g': [1332], '20': [1334, 1383], 'min': [1335], '4°C,': [1337], 'supernatant': [1339, 1367], '−80°C.': [1345], 'protein': [1347, 1357, 1412, 1638], 'concentration': [1348], 'extract': [1351, 1620, 1962, 2283], 'BCA': [1356], 'kit': [1359], '(Pierce,': [1360], 'Rockford,': [1361], 'IL).': [1362], 'A': [1363], 'portion': [1364], 'included': [1369, 2306], 'TRAP': [1372, 1561, 1633, 1811, 1827], 'tube': [1374, 1432, 1457], 'containing': [1375, 1575], '50': [1376, 1400], 'μl': [1377], 'reaction': [1379], 'mixture': [1380], 'composed': [1381], '8.3),': [1387], '63': [1391], '0.005%': [1394], 'Tween': [1395], '20,': [1396], 'μM': [1401], 'dNTPs,': [1402], 'μg': [1404, 1408, 1427, 1579, 1583, 1637, 1643, 1648, 1960, 1967, 1977, 2281, 2288, 2298], 'TS': [1405, 1446], 'primer,': [1406], 'T4': [1409], 'gene': [1410, 3414], '32': [1411], '(Boehringer-Mannheim,': [1413], 'Mannheim,': [1414], 'Germany),': [1415], '2': [1416, 1800, 1970, 2131, 2146, 2159, 2198, 2210, 2222, 2249, 2273, 2291, 2471], 'U': [1417], '(Takara': [1421], 'Shuzo,': [1422], 'Kyoto,': [1423], 'Japan)': [1424], 'CX': [1428], 'primer': [1429, 1447], 'bottom': [1433], 'sequestered': [1434], 'Ampliwax': [1436], '(Perkin': [1437], 'Elmer,': [1438], 'Norwalk,': [1439], 'CT).': [1440], 'added': [1444], 'maintained': [1449], '23°C': [1451], '30': [1453, 1468, 1472], 'min.': [1454], 'processed': [1460], 'through': [1461], 'temperature': [1463], 'cycles': [1464], '95°C': [1466], 'sec,': [1469], '50°C': [1470], 'sec': [1473], '72°C': [1475], '90': [1477], 'sec.': [1478], 'final': [1480], 'products': [1481], 'visualized': [1483, 1489], 'non-denaturing': [1485], '10%': [1486, 2477], 'PAGE': [1487], 'SYBR': [1491], 'green': [1492], 'I': [1493, 1884, 1915, 1935, 2318], 'nucleic': [1494], 'acid': [1495], 'gel': [1496], 'stain': [1497], '(FMC,': [1498], 'Rockland,': [1499], 'ME).': [1500], 'sensitivity': [1502], 'non-RI': [1505], 'conventional': [1514], 'RI-TRAP': [1515], 'assay.': [1516], 'We': [1517, 2927], 'classified': [1518, 1593, 1604, 1698, 1716], 'sample': [1520], 'telomerase-positive': [1522], '6-bp': [1525], 'ladder': [1527], 'observed': [1529, 2843], 'intensity': [1532, 1558], 'equivalent': [1534], 'stronger': [1537], 'than': [1538, 2746, 2774, 2918], 'line': [1550, 1664], '(SiHa).': [1551], 'Because': [1552], 'there': [1553], 'variation': [1555], 'signals': [1562, 1672, 1796, 1828], 'specimens,': [1566], 'estimated': [1568, 2475], 'serially': [1572], 'diluted': [1573, 1601], 'extracts': [1574, 1602], '6': [1576, 1636, 1947, 1957, 2145, 2175, 2220, 2233, 2261, 2278], 'μg,': [1577], '0.6': [1578, 1642, 1959, 1974, 2280, 2295], '(10-fold)': [1580, 1644], '0.06': [1582, 1647, 1966, 1976, 2287, 2297], '(100-fold)': [1584], 'protein.': [1585], 'high,': [1595], 'whereas': [1596, 2533], 'which': [1598, 1691, 1703, 2635, 2690], 'disappeared': [1599], 'low': [1606, 1822, 2923], '(Fig.': [1607], '1).': [1608], 'Figure': [1609], '1Open': [1610], 'figure': [1612], 'viewerPowerPoint': [1613], 'prepared': [1621], 'subjected': [1626], 'serial': [1628, 1785], 'dilutions': [1629], '(standard': [1639], 'condition),': [1640], '(100-fold).': [1649], 'Lysis': [1650], 'used': [1653], 'negative': [1656, 1711, 1964, 2285], 'control': [1657, 1669, 1685], '(Siha)': [1665], '10,': [1674], '1,000': [1677], 'ITAS': [1680], 'band': [1681], 'PCR': [1687], 'amplification.': [1688], 'Case': [1689, 1701, 1719], 'C,': [1690], 'remained': [1692], 'dilution,': [1696, 1714], 'high.': [1700], 'A,': [1702], '10-fold': [1707, 1833], 'became': [1710], 'low.': [1718], 'B': [1720], 'showed': [1721, 2053, 2338], 'Statistical': [1725, 1727], "Fisher's": [1732], 'exact': [1733], 'test;': [1734], 'p': [1735, 1892, 2369], '<': [1736, 1893, 2074, 2346, 2370], '0.05': [1737], 'statistically': [1742, 1851], 'significant.': [1743], 'RESULTS': [1744], '(88.6%)': [1751], 'tissues.': [1756], 'Extracts': [1757], 'all': [1759, 2033, 2077], 'telomerase-negative': [1760, 2035], 'samples': [1761, 2646], 'gave': [1762], 'signal': [1765, 1812], 'standard,': [1771], 'excluding': [1772], 'inhibition.': [1778], 'semi-quantification': [1780], 'extract,': [1789], 'showing': [1793], 'divided': [1798], 'into': [1799, 2516], 'groups:': [1801], '(i.e.,': [1808, 1825], 'retained': [1809], 'extract)': [1818], '16': [1820, 1916, 1945, 1952, 2155], 'expressed': [1826, 2555], 'but': [1835, 1963, 2284, 2464, 3141], 'not': [1836, 1850, 2096, 3142], 'extract).': [1842], 'incidence': [1844, 1860, 2058, 2466], 'regard': [1854], 'stage.': [1857, 2874], 'III': [1870, 1925, 1942, 2334], 'IV': [1872, 1930, 1944, 2336], '(62.5%,': [1874], '16)': [1877], 'II': [1886, 1920, 1937, 2320], '(26.3%,': [1888], '19;': [1891], '0.05;': [1894], 'Table': [1895, 1897, 1991, 2101], 'I).': [1896], 'I.': [1898], 'TELOMERASE': [1899, 2108], 'ACTIVITY': [1900, 2109], 'SURGICAL': [1902], 'STAGE': [1903], 'IN': [1904, 2110], 'ENDOMETRIAL': [1905, 2111], 'CARCINOMA': [1906, 2112], 'Surgical': [1907], 'Number': [1908, 2115], 'Negative': [1912, 2118, 2202, 2214, 2227, 2240, 2253, 2265], 'Low1': [1913, 2119], 'High2': [1914, 2120], '3': [1917, 1921, 1934, 2144, 2161, 2164, 2184, 2199, 2204, 2246, 2255], '9': [1918, 2140, 2141, 2190, 2329], '12': [1926], '0': [1927, 1932, 1946, 2132, 2149, 2166, 2191, 2197, 2221, 2234, 2247, 2272], '7': [1929, 2078, 2158, 2162, 2186, 2208, 2262, 2271, 2327], '+': [1936, 1943], '19': [1938, 2138], 'Total': [1949], 'Positive': [1955, 1971, 2207, 2219, 2232, 2245, 2258, 2270, 2276, 2292], 'extract.': [1969, 1979, 2290, 2300], '6,': [1973, 2294], 'shown': [1989, 2625, 2727], 'II.': [1992, 2102], 'frequency': [2000, 2730], 'myometrial': [2012], 'disease.': [2029], 'Tumor': [2030, 2171], 'strictly': [2038], 'confined': [2039], 'uterus.': [2042, 3390], 'All': [2043], 'adnexal,': [2046], 'metastases': [2052, 2770, 2779], 'metastasis': [2072, 2213, 2226, 2239, 2351, 2362, 2367, 2382, 2734, 2870, 2890], '(p': [2073, 2098, 2345], '0.05).': [2075, 2347, 2371], 'Although': [2076], 'disease': [2082, 2264, 3528], 'tended': [2088], '=': [2099], '0.10).': [2100], 'CORRELATION': [2103], 'BETWEEN': [2104], 'HISTO-PATHOLOGICAL': [2105], 'FACTORS': [2106], 'subtype': [2122], 'Endometrioid': [2123], '33': [2125], '14': [2128, 2160, 2205, 2217, 2230, 2243, 2259, 2268], 'Serous': [2129], 'adenocarcinoma': [2130], 'G1': [2137], 'G2': [2142], '11': [2143, 2206, 2218], 'G3': [2147], 'Nuclear': [2152], '8': [2157, 2231, 2257], 'Myometrial': [2169], 'limited': [2172], 'endometrium': [2174, 2599, 2628, 2680, 2976, 3449], 'Invasion': [2179, 2187], '<1/2': [2181], '>1/2': [2188], 'Serosal': [2194], '28': [2203, 2241, 2266], 'Adnexal': [2212], '29': [2215], 'Pelvic': [2224, 2348], '26': [2228], 'Para-aortic': [2237], '21': [2254], 'Extra-uterine': [2263], 'When': [2301], 'only': [2302, 2653, 2880], 'post-menopausal': [2303, 2389, 2648, 2679, 2881], 'statistical': [2309, 2343], 'analysis,': [2310], '(26.7%)': [2314], 'exhibited': [2322], '(77.8%)': [2330], 'significance': [2344], '(presence': [2360], '66.7%': [2363], 'vs.': [2364], 'absence': [2365], '38.9%,': [2368], 'Thus,': [2372], 'stage,': [2386], 'even': [2387], 'patients.': [2390], 'DISCUSSION': [2391], 'Uterine': [2392], 'one': [2396], 'common': [2399], 'invasive': [2400], 'malignancies': [2401], 'female': [2404, 3007, 3581], 'genital': [2405], 'tract,': [2406], 'prevalence': [2409], 'steadily': [2411], 'increasing': [2412], 'Japan': [2414], 'well': [2416], 'Western': [2419], 'countries.': [2420], 'information': [2422], 'regarding': [2423], 'molecular': [2425, 2507], 'mechanisms': [2426, 2518], 'carcinogenesis': [2429], 'remains': [2430], 'limited.': [2431], 'Mutations': [2432], 'ras': [2434], '(Enomoto': [2435, 2485], '1990;': [2438, 2488], 'Ignar-Trawbridge': [2439, 2493], '1992)': [2442, 2452], 'p53': [2444, 3382, 3413], '(Okamoto': [2445], '1991;': [2448, 2492], 'Risinger': [2449, 2497], 'genes': [2453, 2472], 'involved': [2455], 'mutation': [2468], 'these': [2470], 'low,': [2474], '46%': [2479], '13%': [2481], '14%,': [2483], 'respectively': [2484], 'Okamoto': [2489], '1992;': [2496], '1992).': [2500], 'relatively': [2502], 'new': [2503], 'approach': [2504], 'investigation': [2508], 'telomere–telomerase': [2510], 'interactions': [2511], 'provide': [2513], 'additional': [2514], 'insight': [2515], 'carcinogenesis.': [2521], 'Most': [2522], 'somatic': [2525], 'exhibit': [2527, 2650], 'undetectable': [2528], 'levels': [2529], 'majority': [2535], 'express': [2539], 'shortened': [2543], 'cells,': [2551], 'particularly': [2554], 'embryonic': [2557, 3556], '(Wright': [2559, 2567], '1998),': [2562, 2570], 'adult': [2563], 'male': [2564], 'germ-line': [2565], 'proliferative': [2571], 'renewable': [2574], 'basal': [2578, 2687, 3058], 'epidermis': [2582, 3062], '(Harle-Bachor': [2583], 'Boukamp,': [2585, 3051], '1996),': [2586], 'circulating': [2587], 'peripheral': [2588], 'blood': [2589], 'leukocytes': [2590], 'K.': [2592], 'normally': [2597], 'cycling': [2598], '(1997)': [2615], 'evaluated': [2617], 'semi-quantitative': [2621], 'expresses': [2629], 'regulated': [2637], 'during': [2638], 'menstrual': [2640], 'cycle.': [2641], 'contrast,': [2643, 2786], 'atrophic': [2644], 'women': [2649], 'weak': [2654], 'suggesting': [2673], 'residual': [2675], 'reflects': [2681], 'loss': [2682, 3377], 'function': [2684], 'lining,': [2689], 'longer': [2693], 'capable': [2694], 'regeneration.': [2696], 'Various': [2697], 'investigations': [2698], 'correlating': [2699], 'yielded': [2706], 'conflicting': [2707], 'results.': [2708], 'Studies': [2709], '1996)': [2724, 2799], 'higher': [2745, 2773], 'without': [2750, 2778, 2920], 'pancreatic': [2754, 3139], 'surgically': [2765], 'distant': [2769], 'renal': [2794, 3352], '(Mehle': [2796], 'relationship': [2802], 'parameters,': [2808], 'size,': [2814], 'ploidy,': [2816], 'outcome,': [2820], 'noted.': [2823], 'To': [2824], 'knowledge,': [2826], 'any': [2837], 'found': [2855], 'here': [2856], 'analyzed.': [2884], 'indeed': [2896], 'adverse': [2897], 'determine': [2900], 'poor': [2901], 'prognosis': [2902], 'cancer.': [2907, 3178, 3285], 'aggressive': [2917], 'those': [2919], 'Acknowledgements': [2926], 'thank': [2928], 'Drs.': [2929], 'H.': [2930], 'Hareyama': [2931], '(Sapporo': [2932], 'City': [2933], 'Hospital),': [2934, 2940], 'S.': [2935], 'Shimada': [2936], '(Kushiro': [2937], 'Red': [2938], 'Cross': [2939], 'M.': [2941, 2947], 'Morikawa': [2942], '(Ohji': [2943], 'General': [2944], 'Hospital)': [2945], 'Oikawa': [2948], '(Hokkaido': [2949], 'University)': [2950], 'collection': [2953], 'samples.': [2955], 'REFERENCES': [2956], 'Brien,': [2957], 'T.P.,': [2958], 'Kallakury,': [2959], 'B.V.,': [2960], 'Lowry,': [2961], 'C.V.,': [2962], 'Ambros,': [2963], 'R.A.,': [2964], 'Muraca,': [2965], 'P.J.,': [2966], 'Malfetano,': [2967], 'J.H.,': [2968], 'Ross,': [2970], 'J.S.,': [2971], 'benign': [2975, 3144], 'Res.,': [2981, 3011, 3147, 3180, 3310, 3331, 3392, 3533], '57,': [2982, 3148, 3332], '2760–': [2983], '2764': [2984], '(1997).': [2985, 3046, 3151, 3335, 3465, 3499], 'Medline': [2986, 3016, 3047, 3152, 3185, 3221, 3253, 3291, 3315, 3336, 3360, 3397, 3426, 3466, 3500, 3538, 3592], 'Enomoto,': [2987, 3480], 'T.,': [2988, 3022, 3087, 3091, 3118, 3122, 3133, 3156, 3166, 3295, 3321, 3428, 3481, 3504, 3517, 3576], 'Inoue,': [2989, 3301, 3323], 'M.,': [2990, 3028, 3124, 3193, 3204, 3229, 3302, 3319, 3324, 3372, 3409, 3436, 3506], 'Perantoni,': [2991], 'A.O.,': [2992], 'Terakawa,': [2993], 'N.,': [2994, 3158, 3432, 3474], 'Tanizawa,': [2995], 'O.,': [2996], 'Rice,': [2998], 'J.M.,': [2999], 'K-ras': [3000], 'activation': [3001], 'neoplasms': [3003], 'reproductive': [3008, 3582], 'tract.': [3009], '50,': [3012, 3043], '6139–': [3013], '6145': [3014], '(1990).': [3015], 'Garham,': [3017], 'H.,': [3018, 3297, 3299, 3434, 3441, 3502], 'Yoshida,': [3019], 'K.,': [3020, 3089, 3095, 3120, 3126, 3160, 3187], 'Sugino,': [3021], 'Marsh,': [3023], 'G.,': [3024, 3347, 3514], 'Manek,': [3025], 'S.,': [3026, 3033, 3191, 3201, 3293, 3317, 3368], 'Charnock,': [3027], 'Tarin,': [3029], 'D.,': [3030, 3223, 3403], 'Goodison,': [3032], 'malignancies.': [3039], 'clin.': [3041], 'Pathol.,': [3042, 3495], '501–': [3044], '504': [3045], 'Harle-Bachor,': [3048], 'C.,': [3049, 3338], 'P.,': [3052], 'regenerative': [3057], 'layer': [3059], 'skin': [3065, 3071], 'immortal': [3068, 3282], 'carcinoma-derived': [3070], 'keratinocytes.': [3072], 'Proc.': [3073], 'nat.': [3074, 3108], 'Acad.': [3075], 'Sci.': [3076], '(Wash.),': [3077], '93,': [3078], '6476–': [3079], '6481': [3080], '(1996).': [3081, 3114, 3314, 3359], 'Hiyama,': [3082, 3094, 3115, 3125, 3153, 3159, 3186, 3194], 'Gollahon,': [3084], 'L.,': [3085], 'Kataoka,': [3086], 'Kuroi,': [3088], 'Yokoyama,': [3090, 3132, 3155, 3566], 'Gazdar,': [3092], 'A.F.,': [3093], 'Piatyszek,': [3096, 3167, 3196, 3256, 3339, 3541], 'M.A.,': [3097, 3168, 3197, 3257, 3340, 3542], 'Shay,': [3099, 3127, 3169, 3198, 3273, 3343, 3509, 3548], 'J.W.,': [3100, 3128, 3170, 3199, 3274, 3344, 3510], 'Inst.,': [3110], '88,': [3111], '116–': [3112], '122': [3113], 'Kodama,': [3117, 3165], 'Shinbara,': [3119], 'Iwao,': [3121], 'Itoh,': [3123], 'Matsuura,': [3129, 3172], 'Y.,': [3130, 3162, 3164, 3173, 3189, 3364, 3366, 3370, 3567, 3569], '326–': [3149], '331': [3150], 'Tatsumoto,': [3157], 'Imamura,': [3161], 'Murakami,': [3163], '55,': [3181, 3534], '3258–': [3182], '3262': [3183], '(1995).': [3184, 3220, 3537], 'Hirai,': [3188], 'Kyoizumi,': [3190], 'Akiyama,': [3192], 'Ishioka,': [3200], 'Yamakido,': [3203], 'Activation': [3205], 'lymphocytes': [3210], 'hematopoietic': [3212], 'progenitor': [3213], 'Immunol.,': [3216], '155,': [3217], '3711–': [3218], '3715': [3219], 'Ignar-Trawbridge,': [3222], 'Risinger,': [3224, 3398], 'J.I.,': [3225, 3399], 'Dent,': [3226, 3400], 'G.A.,': [3227, 3401], 'Kohler,': [3228], 'Berchuck,': [3230], 'A.,': [3231, 3362, 3430, 3571], 'McLachlan,': [3232, 3404], 'J.A.,': [3233, 3405], 'Boyd,': [3235, 3411], 'J.,': [3236, 3375, 3412], 'Mutation': [3237], 'Ki-ras': [3240], 'oncogene': [3241], 'Amer.': [3245], 'Obstet.': [3247], 'Gynecol.,': [3248], '167,': [3249], '227–': [3250], '232': [3251, 3498], '(1992).': [3252, 3425], 'Kim,': [3254], 'N.M.,': [3255], 'Prowse,': [3258], 'K.R.,': [3259, 3468], 'Harley,': [3260], 'C.B.,': [3261], 'West,': [3262], 'M.D.,': [3263], 'Ho,': [3264], 'P.L.C.,': [3265], 'Coviello,': [3266], 'G.M.,': [3267], 'Wright,': [3268, 3539], 'W.E.,': [3269, 3544], 'Weinrich,': [3270], 'S.L.,': [3271], 'Specific': [3275], 'association': [3276], '266,': [3287], '2011–': [3288], '2015': [3289], '(1994).': [3290], 'Kyo,': [3292, 3316], 'Kanaya,': [3294], 'Ishikawa,': [3296], 'Ueno,': [3298], 'Clin.': [3308], '2,': [3311], '2023–': [3312], '2028': [3313], 'Takakura,': [3318], 'Kohama,': [3320], 'endometrium.': [3329], '610–': [3333, 3463], '614': [3334, 3464], 'Mehle,': [3337], 'Ljungberg,': [3341], 'B.,': [3342], 'Roos,': [3346], 'Oncogene,': [3355], '13,': [3356], '161–': [3357], '166': [3358], 'Okamoto,': [3361], 'Sameshima,': [3363], 'Teshima,': [3367], 'Terashima,': [3369], 'Terada,': [3371], 'Yokota,': [3374], 'Allelic': [3376], 'chromosome': [3379], '17p': [3380], 'mutations': [3383, 3415], '51,': [3393], '5632–': [3394], '6536': [3395], '(1991).': [3396], 'Ignar-Trowbridge,': [3402], 'Tsao,': [3406], 'M.S.,': [3407], 'Senterman,': [3408], 'Mol.': [3420], 'Carcinogenesis,': [3421], '5,': [3422], '250–': [3423], '253': [3424], 'Saito,': [3427], 'Schneider,': [3429], 'Martel,': [3431], 'Mizumoto,': [3433], 'Bulgay-Maerschel,': [3435], 'Kudo,': [3437], 'R.,': [3438, 3508], 'Nakazawa,': [3440], 'Proliferation-associated': [3442], 'regulation': [3443], 'implication': [3453], 'early': [3455], 'diagnosis.': [3457], 'Biochem.': [3458], 'biophys.': [3459], 'Res.': [3460], 'Comm.,': [3461], '231,': [3462], 'Shroyer,': [3467, 3475], 'Stephens,': [3469], 'J.K.,': [3470], 'Silverberg,': [3471], 'S.G.,': [3472], 'Markham,': [3473], 'A.L.,': [3476], 'Wilson,': [3477], 'M.L.,': [3478], 'expression': [3483], 'endometrium,': [3486], 'hyperplasia,': [3488], 'adenocarcinoma.': [3491], 'Gynecol.': [3494, 3586], '16,': [3496], '225–': [3497], 'Tahara,': [3501, 3511], 'Nakanishi,': [3503], 'Kitamoto,': [3505], 'Nakashio,': [3507], 'Kajiyama,': [3513], 'Ide,': [3516], 'liver': [3522, 3527], 'tissues:': [3523], 'comparison': [3524], 'chronic': [3526], 'carcinomas.': [3531], '2734–': [3535], '2736': [3536], 'W.A.,': [3540], 'Rainey,': [3543], 'Byrd,': [3545], 'W.,': [3546], 'A.W.,': [3549], 'germline': [3554], 'Develop.': [3560], 'Genet.,': [3561], '18,': [3562], '173–': [3563], '179': [3564], '(1998).': [3565, 3591], 'Takahashi,': [3568], 'Shinohara,': [3570], 'Lian,': [3572], 'Z.,': [3573], 'Tamaya,': [3575], 'tract': [3583], 'neoplasms.': [3585], 'Oncol.,': [3587], '68,': [3588], '145–': [3589], '149': [3590], 'Citing': [3593], 'Literature': [3594], 'Volume84,': [3595], 'Issue522': [3596], 'October': [3597], '1999Pages': [3598], 'FiguresReferencesRelatedInformation': [3600]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2094169830', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 1}], 'updated_date': '2024-09-19T09:40:49.712428', 'created_date': '2016-06-24'}