Discovery of the First Potent and Selective Small Molecule Opioid Receptor-like (ORL1) Antagonist: 1-[(3R,4R)-1-Cyclooctylmethyl-3- hydroxymethyl-4-piperidyl]-3-ethyl- 1,3-dihydro-2H-benzimidazol-2-one (J-113397)

Name: Work Video:
Duration: 3 min 30 s
Hiroshi Kawamoto; Satoshi Ozaki; Yoshiki Itoh; Mitsuru Miyaji; Sachie Arai; Hiroshi Nakashima; Tetsuya Kato; Hisashi Ohta; Yoshikazu Iwasawa
{'id': 'https://openalex.org/W2094167697', 'doi': 'https://doi.org/10.1021/jm990517p', 'title': 'Discovery of the First Potent and Selective Small Molecule Opioid Receptor-like (ORL1) Antagonist: 1-[(3<i>R</i>,4<i>R</i>)-1-Cyclooctylmethyl-3- hydroxymethyl-4-piperidyl]-3-ethyl- 1,3-dihydro-2<i>H</i>-benzimidazol-2-one (J-113397)', 'display_name': 'Discovery of the First Potent and Selective Small Molecule Opioid Receptor-like (ORL1) Antagonist: 1-[(3<i>R</i>,4<i>R</i>)-1-Cyclooctylmethyl-3- hydroxymethyl-4-piperidyl]-3-ethyl- 1,3-dihydro-2<i>H</i>-benzimidazol-2-one (J-113397)', 'publication_year': 1999, 'publication_date': '1999-11-19', 'ids': {'openalex': 'https://openalex.org/W2094167697', 'doi': 'https://doi.org/10.1021/jm990517p', 'mag': '2094167697', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/10602690'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1021/jm990517p', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S162030435', 'display_name': 'Journal of Medicinal Chemistry', 'issn_l': '0022-2623', 'issn': ['0022-2623', '1520-4804'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320006', 'host_organization_name': 'American Chemical Society', 'host_organization_lineage': ['https://openalex.org/P4310320006'], 'host_organization_lineage_names': ['American Chemical Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5000151617', 'display_name': 'Hiroshi Kawamoto', 'orcid': 'https://orcid.org/0000-0002-7670-9900'}, 'institutions': [{'id': 'https://openalex.org/I1285764155', 'display_name': 'Merck & Co., Inc., Rahway, NJ, USA (United States)', 'ror': 'https://ror.org/02891sr49', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I1285764155']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Hiroshi Kawamoto', 'raw_affiliation_strings': ['Banyu Tsukuba Research Institute in collaboration with Merck Research Laboratories, Banyu Pharmaceutical Company Ltd., Okubo 3, Tsukuba, Ibaraki 300-2611, Japan.'], 'affiliations': [{'raw_affiliation_string': 'Banyu Tsukuba Research Institute in collaboration with Merck Research Laboratories, Banyu Pharmaceutical Company Ltd., Okubo 3, Tsukuba, Ibaraki 300-2611, Japan.', 'institution_ids': ['https://openalex.org/I1285764155']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5110080210', 'display_name': 'Satoshi Ozaki', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1285764155', 'display_name': 'Merck & Co., Inc., Rahway, NJ, USA (United States)', 'ror': 'https://ror.org/02891sr49', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I1285764155']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Satoshi Ozaki', 'raw_affiliation_strings': ['Banyu Tsukuba Research Institute in collaboration with Merck Research Laboratories, Banyu Pharmaceutical Company Ltd., Okubo 3, Tsukuba, Ibaraki 300-2611, Japan.'], 'affiliations': [{'raw_affiliation_string': 'Banyu Tsukuba Research Institute in collaboration with Merck Research Laboratories, Banyu Pharmaceutical Company Ltd., Okubo 3, Tsukuba, Ibaraki 300-2611, Japan.', 'institution_ids': ['https://openalex.org/I1285764155']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5039872054', 'display_name': 'Yoshiki Itoh', 'orcid': 'https://orcid.org/0000-0002-8258-0402'}, 'institutions': [{'id': 'https://openalex.org/I1285764155', 'display_name': 'Merck & Co., Inc., Rahway, NJ, USA (United States)', 'ror': 'https://ror.org/02891sr49', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I1285764155']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Yoshiki Itoh', 'raw_affiliation_strings': ['Banyu Tsukuba Research Institute in collaboration with Merck Research Laboratories, Banyu Pharmaceutical Company Ltd., Okubo 3, Tsukuba, Ibaraki 300-2611, Japan.'], 'affiliations': [{'raw_affiliation_string': 'Banyu Tsukuba Research Institute in collaboration with Merck Research Laboratories, Banyu Pharmaceutical Company Ltd., Okubo 3, Tsukuba, Ibaraki 300-2611, Japan.', 'institution_ids': ['https://openalex.org/I1285764155']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5072924541', 'display_name': 'Mitsuru Miyaji', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1285764155', 'display_name': 'Merck & Co., Inc., Rahway, NJ, USA (United States)', 'ror': 'https://ror.org/02891sr49', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I1285764155']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Mitsuru Miyaji', 'raw_affiliation_strings': ['Banyu Tsukuba Research Institute in collaboration with Merck Research Laboratories, Banyu Pharmaceutical Company Ltd., Okubo 3, Tsukuba, Ibaraki 300-2611, Japan.'], 'affiliations': [{'raw_affiliation_string': 'Banyu Tsukuba Research Institute in collaboration with Merck Research Laboratories, Banyu Pharmaceutical Company Ltd., Okubo 3, Tsukuba, Ibaraki 300-2611, Japan.', 'institution_ids': ['https://openalex.org/I1285764155']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5110027971', 'display_name': 'Sachie Arai', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1285764155', 'display_name': 'Merck & Co., Inc., Rahway, NJ, USA (United States)', 'ror': 'https://ror.org/02891sr49', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I1285764155']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Sachie Arai', 'raw_affiliation_strings': ['Banyu Tsukuba Research Institute in collaboration with Merck Research Laboratories, Banyu Pharmaceutical Company Ltd., Okubo 3, Tsukuba, Ibaraki 300-2611, Japan.'], 'affiliations': [{'raw_affiliation_string': 'Banyu Tsukuba Research Institute in collaboration with Merck Research Laboratories, Banyu Pharmaceutical Company Ltd., Okubo 3, Tsukuba, Ibaraki 300-2611, Japan.', 'institution_ids': ['https://openalex.org/I1285764155']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5105686295', 'display_name': 'Hiroshi Nakashima', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1285764155', 'display_name': 'Merck & Co., Inc., Rahway, NJ, USA (United States)', 'ror': 'https://ror.org/02891sr49', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I1285764155']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Hiroshi Nakashima', 'raw_affiliation_strings': ['Banyu Tsukuba Research Institute in collaboration with Merck Research Laboratories, Banyu Pharmaceutical Company Ltd., Okubo 3, Tsukuba, Ibaraki 300-2611, Japan.'], 'affiliations': [{'raw_affiliation_string': 'Banyu Tsukuba Research Institute in collaboration with Merck Research Laboratories, Banyu Pharmaceutical Company Ltd., Okubo 3, Tsukuba, Ibaraki 300-2611, Japan.', 'institution_ids': ['https://openalex.org/I1285764155']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5113459187', 'display_name': 'Tetsuya Kato', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1285764155', 'display_name': 'Merck & Co., Inc., Rahway, NJ, USA (United States)', 'ror': 'https://ror.org/02891sr49', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I1285764155']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Tetsuya Kato', 'raw_affiliation_strings': ['Banyu Tsukuba Research Institute in collaboration with Merck Research Laboratories, Banyu Pharmaceutical Company Ltd., Okubo 3, Tsukuba, Ibaraki 300-2611, Japan.'], 'affiliations': [{'raw_affiliation_string': 'Banyu Tsukuba Research Institute in collaboration with Merck Research Laboratories, Banyu Pharmaceutical Company Ltd., Okubo 3, Tsukuba, Ibaraki 300-2611, Japan.', 'institution_ids': ['https://openalex.org/I1285764155']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5062700753', 'display_name': 'Hisashi Ohta', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1285764155', 'display_name': 'Merck & Co., Inc., Rahway, NJ, USA (United States)', 'ror': 'https://ror.org/02891sr49', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I1285764155']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Hisashi Ohta', 'raw_affiliation_strings': ['Banyu Tsukuba Research Institute in collaboration with Merck Research Laboratories, Banyu Pharmaceutical Company Ltd., Okubo 3, Tsukuba, Ibaraki 300-2611, Japan.'], 'affiliations': [{'raw_affiliation_string': 'Banyu Tsukuba Research Institute in collaboration with Merck Research Laboratories, Banyu Pharmaceutical Company Ltd., Okubo 3, Tsukuba, Ibaraki 300-2611, Japan.', 'institution_ids': ['https://openalex.org/I1285764155']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5108474461', 'display_name': 'Yoshikazu Iwasawa', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1285764155', 'display_name': 'Merck & Co., Inc., Rahway, NJ, USA (United States)', 'ror': 'https://ror.org/02891sr49', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I1285764155']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Yoshikazu Iwasawa', 'raw_affiliation_strings': ['Banyu Tsukuba Research Institute in collaboration with Merck Research Laboratories, Banyu Pharmaceutical Company Ltd., Okubo 3, Tsukuba, Ibaraki 300-2611, Japan.'], 'affiliations': [{'raw_affiliation_string': 'Banyu Tsukuba Research Institute in collaboration with Merck Research Laboratories, Banyu Pharmaceutical Company Ltd., Okubo 3, Tsukuba, Ibaraki 300-2611, Japan.', 'institution_ids': ['https://openalex.org/I1285764155']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 6.56, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 204, 'citation_normalized_percentile': {'value': 0.9471, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '42', 'issue': '25', 'first_page': '5061', 'last_page': '5063'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10814', 'display_name': 'Neuropeptides and Animal Physiology', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10814', 'display_name': 'Neuropeptides and Animal Physiology', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11178', 'display_name': 'Receptor Mechanisms and Signaling', 'score': 0.9991, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T13047', 'display_name': 'Pharmacological Receptor Mechanisms and Effects', 'score': 0.9972, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/nociceptin-receptor', 'display_name': 'Nociceptin receptor', 'score': 0.9580883}, {'id': 'https://openalex.org/keywords/hydroxymethyl', 'display_name': 'Hydroxymethyl', 'score': 0.7941309}], 'concepts': [{'id': 'https://openalex.org/C125439840', 'wikidata': 'https://www.wikidata.org/wiki/Q14911984', 'display_name': 'Nociceptin receptor', 'level': 5, 'score': 0.9580883}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.9460012}, {'id': 'https://openalex.org/C2780591741', 'wikidata': 'https://www.wikidata.org/wiki/Q899405', 'display_name': 'Hydroxymethyl', 'level': 2, 'score': 0.7941309}, {'id': 'https://openalex.org/C2776885963', 'wikidata': 'https://www.wikidata.org/wiki/Q245204', 'display_name': 'Antagonist', 'level': 3, 'score': 0.6319528}, {'id': 'https://openalex.org/C71240020', 'wikidata': 'https://www.wikidata.org/wiki/Q186011', 'display_name': 'Stereochemistry', 'level': 1, 'score': 0.54144174}, {'id': 'https://openalex.org/C2779886867', 'wikidata': 'https://www.wikidata.org/wiki/Q421797', 'display_name': 'Opioid receptor', 'level': 4, 'score': 0.50874215}, {'id': 'https://openalex.org/C2781063702', 'wikidata': 'https://www.wikidata.org/wiki/Q427523', 'display_name': 'Opioid', 'level': 3, 'score': 0.49488276}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.4590321}, {'id': 'https://openalex.org/C32909587', 'wikidata': 'https://www.wikidata.org/wiki/Q11369', 'display_name': 'Molecule', 'level': 2, 'score': 0.43749937}, {'id': 'https://openalex.org/C161624437', 'wikidata': 'https://www.wikidata.org/wiki/Q1988322', 'display_name': 'Small molecule', 'level': 2, 'score': 0.43726915}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.3518546}, {'id': 'https://openalex.org/C88016717', 'wikidata': 'https://www.wikidata.org/wiki/Q417189', 'display_name': 'Opioid peptide', 'level': 4, 'score': 0.14767635}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.13541049}, {'id': 'https://openalex.org/C178790620', 'wikidata': 'https://www.wikidata.org/wiki/Q11351', 'display_name': 'Organic chemistry', 'level': 1, 'score': 0.12112364}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D001562', 'descriptor_name': 'Benzimidazoles', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D010880', 'descriptor_name': 'Piperidines', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D011957', 'descriptor_name': 'Receptors, Opioid', 'qualifier_ui': 'Q000819', 'qualifier_name': 'agonists', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001562', 'descriptor_name': 'Benzimidazoles', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D001562', 'descriptor_name': 'Benzimidazoles', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010880', 'descriptor_name': 'Piperidines', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D010880', 'descriptor_name': 'Piperidines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011957', 'descriptor_name': 'Receptors, Opioid', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013329', 'descriptor_name': 'Structure-Activity Relationship', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1021/jm990517p', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S162030435', 'display_name': 'Journal of Medicinal Chemistry', 'issn_l': '0022-2623', 'issn': ['0022-2623', '1520-4804'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320006', 'host_organization_name': 'American Chemical Society', 'host_organization_lineage': ['https://openalex.org/P4310320006'], 'host_organization_lineage_names': ['American Chemical Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/10602690', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 17, 'referenced_works': ['https://openalex.org/W1573332568', 'https://openalex.org/W1598044684', 'https://openalex.org/W1606326824', 'https://openalex.org/W1973370124', 'https://openalex.org/W1979692501', 'https://openalex.org/W1987575768', 'https://openalex.org/W1989521646', 'https://openalex.org/W1998454224', 'https://openalex.org/W2016562510', 'https://openalex.org/W2018910234', 'https://openalex.org/W2038749392', 'https://openalex.org/W2071617609', 'https://openalex.org/W2072100234', 'https://openalex.org/W2077530921', 'https://openalex.org/W2078867001', 'https://openalex.org/W2079317155', 'https://openalex.org/W2093513199'], 'related_works': ['https://openalex.org/W2172445668', 'https://openalex.org/W2164524573', 'https://openalex.org/W2139060090', 'https://openalex.org/W2130699565', 'https://openalex.org/W2096489825', 'https://openalex.org/W2040403963', 'https://openalex.org/W2009644683', 'https://openalex.org/W1983587230', 'https://openalex.org/W1979495245', 'https://openalex.org/W1978818746'], 'abstract_inverted_index': {'ADVERTISEMENT': [0], 'RETURN': [1], 'TO': [2], 'ISSUELetterNEXTDiscovery': [3], 'of': [4, 101, 136, 162], 'the': [5, 98, 129, 134, 163, 174, 187, 190, 195, 202, 208], 'First': [6], 'Potent': [7], 'and': [8, 35, 111, 116, 145, 189, 206, 222, 224, 235], 'Selective': [9], 'Small': [10], 'Molecule': [11], 'Opioid': [12], 'Receptor-like': [13], '(ORL1)': [14], 'Antagonist:': [15], '1-[(3R,4R)-1-Cyclooctylmethyl-3-': [16], 'hydroxymethyl-4-piperidyl]-3-ethyl-': [17], '1,3-dihydro-2H-benzimidazol-2-one': [18], '(J-113397)Hiroshi': [19], 'Kawamoto,': [20], 'Satoshi': [21], 'Ozaki,': [22], 'Yoshiki': [23], 'Itoh,': [24], 'Mitsuru': [25], 'Miyaji,': [26], 'Sachie': [27], 'Arai,': [28], 'Hiroshi': [29], 'Nakashima,': [30], 'Tetsuya': [31], 'Kato,': [32], 'Hisashi': [33], 'Ohta,': [34], 'Yoshikazu': [36], 'IwasawaView': [37], 'Author': [38], 'Information': [39], 'Banyu': [40, 50], 'Tsukuba': [41], 'Research': [42, 48], 'Institute': [43], 'in': [44], 'collaboration': [45], 'with': [46, 183, 218], 'Merck': [47], 'Laboratories,': [49], 'Pharmaceutical': [51], 'Company': [52], 'Ltd.,': [53], 'Okubo': [54], '3,': [55], 'Tsukuba,': [56], 'Ibaraki': [57], '300-2611,': [58], 'Japan': [59], 'Cite': [60], 'this:': [61], 'J.': [62], 'Med.': [63], 'Chem.': [64], '1999,': [65], '42,': [66], '25,': [67], '5061–5063Publication': [68], 'Date': [69], '(Web):November': [70], '19,': [71], '1999Publication': [72], 'History': [73], 'Received14': [74], 'October': [75], '1999Published': [76, 79], 'online19': [77], 'November': [78, 107], 'inissue': [80], '1': [81], 'December': [82], '1999https://pubs.acs.org/doi/10.1021/jm990517phttps://doi.org/10.1021/jm990517prapid-communicationACS': [83], 'PublicationsCopyright': [84], '©': [85], '1999': [86], 'American': [87], 'Chemical': [88], 'SocietyRequest': [89], 'reuse': [90], 'permissionsArticle': [91], 'Views825Altmetric-Citations182LEARN': [92], 'ABOUT': [93], 'THESE': [94], 'METRICSArticle': [95], 'Views': [96], 'are': [97, 120, 133], 'COUNTER-compliant': [99], 'sum': [100], 'full': [102], 'text': [103], 'article': [104, 168], 'downloads': [105], 'since': [106], '2008': [108], '(both': [109], 'PDF': [110], 'HTML)': [112], 'across': [113], 'all': [114], 'institutions': [115], 'individuals.': [117], 'These': [118], 'metrics': [119], 'regularly': [121], 'updated': [122, 146], 'to': [123, 128], 'reflect': [124], 'usage': [125], 'leading': [126], 'up': [127], 'last': [130], 'few': [131], 'days.Citations': [132], 'number': [135], 'other': [137], 'articles': [138], 'citing': [139], 'this': [140], 'article,': [141], 'calculated': [142], 'by': [143], 'Crossref': [144, 152], 'daily.': [147], 'Find': [148, 198], 'more': [149, 199], 'information': [150, 200], 'about': [151, 186], 'citation': [153], 'counts.The': [154], 'Altmetric': [155, 203], 'Attention': [156, 204], 'Score': [157, 205], 'is': [158, 210], 'a': [159, 166, 179], 'quantitative': [160], 'measure': [161], 'attention': [164], 'that': [165], 'research': [167], 'has': [169], 'received': [170], 'online.': [171], 'Clicking': [172], 'on': [173, 201], 'donut': [175], 'icon': [176], 'will': [177], 'load': [178], 'page': [180], 'at': [181], 'altmetric.com': [182], 'additional': [184], 'details': [185], 'score': [188, 209], 'social': [191], 'media': [192], 'presence': [193], 'for': [194], 'given': [196], 'article.': [197], 'how': [207], 'calculated.': [211], 'Share': [212, 227], 'Add': [213], 'toView': [214], 'InAdd': [215], 'Full': [216], 'Text': [217], 'ReferenceAdd': [219], 'Description': [220], 'ExportRISCitationCitation': [221], 'abstractCitation': [223], 'referencesMore': [225], 'Options': [226], 'onFacebookTwitterWechatLinked': [228], 'InRedditEmail': [229], 'Other': [230], 'access': [231], 'optionsGet': [232], 'e-Alertsclose': [233], 'SUBJECTS:Antagonists,Peptides': [234], 'proteins,Receptors,Screening': [236], 'assays,Selectivity': [237], 'Get': [238], 'e-Alerts': [239]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2094167697', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 4}, {'year': 2021, 'cited_by_count': 7}, {'year': 2020, 'cited_by_count': 3}, {'year': 2019, 'cited_by_count': 3}, {'year': 2018, 'cited_by_count': 5}, {'year': 2017, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 3}, {'year': 2015, 'cited_by_count': 4}, {'year': 2014, 'cited_by_count': 7}, {'year': 2013, 'cited_by_count': 12}, {'year': 2012, 'cited_by_count': 2}], 'updated_date': '2024-12-17T18:19:30.623042', 'created_date': '2016-06-24'}
Publication Information

Basic Information

Access and Citation

AI Researcher Chatbot

Primary Location

Authors

Topics

Keywords

Related Works
