Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2094165198', 'doi': 'https://doi.org/10.1021/bi201203y', 'title': 'Plasmin Substrate Binding Site Cooperativity Guides the Design of Potent Peptide Aldehyde Inhibitors', 'display_name': 'Plasmin Substrate Binding Site Cooperativity Guides the Design of Potent Peptide Aldehyde Inhibitors', 'publication_year': 2011, 'publication_date': '2011-08-30', 'ids': {'openalex': 'https://openalex.org/W2094165198', 'doi': 'https://doi.org/10.1021/bi201203y', 'mag': '2094165198', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/21877690'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1021/bi201203y', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S104038378', 'display_name': 'Biochemistry', 'issn_l': '0006-2960', 'issn': ['0006-2960', '1520-4995', '1943-295X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320006', 'host_organization_name': 'American Chemical Society', 'host_organization_lineage': ['https://openalex.org/P4310320006'], 'host_organization_lineage_names': ['American Chemical Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5073108453', 'display_name': 'Joakim E. Swedberg', 'orcid': 'https://orcid.org/0000-0003-4243-8660'}, 'institutions': [{'id': 'https://openalex.org/I160993911', 'display_name': 'Queensland University of Technology', 'ror': 'https://ror.org/03pnv4752', 'country_code': 'AU', 'type': 'education', 'lineage': ['https://openalex.org/I160993911']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'Joakim E. Swedberg', 'raw_affiliation_strings': ['Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland 4059, Australia'], 'affiliations': [{'raw_affiliation_string': 'Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland 4059, Australia', 'institution_ids': ['https://openalex.org/I160993911']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5056349566', 'display_name': 'Jonathan M. Harris', 'orcid': 'https://orcid.org/0000-0003-4209-2380'}, 'institutions': [{'id': 'https://openalex.org/I160993911', 'display_name': 'Queensland University of Technology', 'ror': 'https://ror.org/03pnv4752', 'country_code': 'AU', 'type': 'education', 'lineage': ['https://openalex.org/I160993911']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'Jonathan M. Harris', 'raw_affiliation_strings': ['Institute of Health and#R#Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland#R#4059, Australia'], 'affiliations': [{'raw_affiliation_string': 'Institute of Health and#R#Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland#R#4059, Australia', 'institution_ids': ['https://openalex.org/I160993911']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 1.296, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 37, 'citation_normalized_percentile': {'value': 0.999985, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 93, 'max': 94}, 'biblio': {'volume': '50', 'issue': '39', 'first_page': '8454', 'last_page': '8462'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10911', 'display_name': 'Chemical Synthesis and Analysis', 'score': 0.9985, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10911', 'display_name': 'Chemical Synthesis and Analysis', 'score': 0.9985, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10620', 'display_name': 'Protease and Inhibitor Mechanisms', 'score': 0.9956, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11917', 'display_name': 'Coagulation, Bradykinin, Polyphosphates, and Angioedema', 'score': 0.9914, 'subfield': {'id': 'https://openalex.org/subfields/2716', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/cooperativity', 'display_name': 'Cooperativity', 'score': 0.76509225}, {'id': 'https://openalex.org/keywords/cooperative-binding', 'display_name': 'Cooperative binding', 'score': 0.60944855}], 'concepts': [{'id': 'https://openalex.org/C2781071845', 'wikidata': 'https://www.wikidata.org/wiki/Q21173374', 'display_name': 'Plasmin', 'level': 3, 'score': 0.8024733}, {'id': 'https://openalex.org/C166014724', 'wikidata': 'https://www.wikidata.org/wiki/Q337217', 'display_name': 'Cooperativity', 'level': 2, 'score': 0.76509225}, {'id': 'https://openalex.org/C2779281246', 'wikidata': 'https://www.wikidata.org/wiki/Q172847', 'display_name': 'Peptide', 'level': 2, 'score': 0.6854805}, {'id': 'https://openalex.org/C107824862', 'wikidata': 'https://www.wikidata.org/wiki/Q616005', 'display_name': 'Binding site', 'level': 2, 'score': 0.6495228}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.649072}, {'id': 'https://openalex.org/C187250156', 'wikidata': 'https://www.wikidata.org/wiki/Q2902610', 'display_name': 'Cooperative binding', 'level': 3, 'score': 0.60944855}, {'id': 'https://openalex.org/C2777289219', 'wikidata': 'https://www.wikidata.org/wiki/Q7632154', 'display_name': 'Substrate (aquarium)', 'level': 2, 'score': 0.53132766}, {'id': 'https://openalex.org/C2779825165', 'wikidata': 'https://www.wikidata.org/wiki/Q101497', 'display_name': 'Aldehyde', 'level': 3, 'score': 0.43854707}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.42727372}, {'id': 'https://openalex.org/C71240020', 'wikidata': 'https://www.wikidata.org/wiki/Q186011', 'display_name': 'Stereochemistry', 'level': 1, 'score': 0.37438095}, {'id': 'https://openalex.org/C21951064', 'wikidata': 'https://www.wikidata.org/wiki/Q899212', 'display_name': 'Combinatorial chemistry', 'level': 1, 'score': 0.34523636}, {'id': 'https://openalex.org/C12554922', 'wikidata': 'https://www.wikidata.org/wiki/Q7100', 'display_name': 'Biophysics', 'level': 1, 'score': 0.33906978}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.2909935}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.10779667}, {'id': 'https://openalex.org/C161790260', 'wikidata': 'https://www.wikidata.org/wiki/Q82264', 'display_name': 'Catalysis', 'level': 2, 'score': 0.071471125}, {'id': 'https://openalex.org/C18903297', 'wikidata': 'https://www.wikidata.org/wiki/Q7150', 'display_name': 'Ecology', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000933', 'descriptor_name': 'Antifibrinolytic Agents', 'qualifier_ui': 'Q000138', 'qualifier_name': 'chemical synthesis', 'is_major_topic': True}, {'descriptor_ui': 'D001665', 'descriptor_name': 'Binding Sites', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D005341', 'descriptor_name': 'Fibrinolysin', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D009842', 'descriptor_name': 'Oligopeptides', 'qualifier_ui': 'Q000138', 'qualifier_name': 'chemical synthesis', 'is_major_topic': True}, {'descriptor_ui': 'D000933', 'descriptor_name': 'Antifibrinolytic Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000933', 'descriptor_name': 'Antifibrinolytic Agents', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D007611', 'descriptor_name': 'Aprotinin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007611', 'descriptor_name': 'Aprotinin', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D015195', 'descriptor_name': 'Drug Design', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005341', 'descriptor_name': 'Fibrinolysin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007700', 'descriptor_name': 'Kinetics', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009842', 'descriptor_name': 'Oligopeptides', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D009842', 'descriptor_name': 'Oligopeptides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1021/bi201203y', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S104038378', 'display_name': 'Biochemistry', 'issn_l': '0006-2960', 'issn': ['0006-2960', '1520-4995', '1943-295X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320006', 'host_organization_name': 'American Chemical Society', 'host_organization_lineage': ['https://openalex.org/P4310320006'], 'host_organization_lineage_names': ['American Chemical Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/21877690', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'score': 0.8, 'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 60, 'referenced_works': ['https://openalex.org/W143880323', 'https://openalex.org/W1546306621', 'https://openalex.org/W1614733900', 'https://openalex.org/W1629966220', 'https://openalex.org/W1961340888', 'https://openalex.org/W1964622103', 'https://openalex.org/W1967322305', 'https://openalex.org/W1977497608', 'https://openalex.org/W1986299008', 'https://openalex.org/W1989016864', 'https://openalex.org/W1990441125', 'https://openalex.org/W2011713635', 'https://openalex.org/W2011964132', 'https://openalex.org/W2014740125', 'https://openalex.org/W2018716482', 'https://openalex.org/W2020402700', 'https://openalex.org/W2021315352', 'https://openalex.org/W2023815739', 'https://openalex.org/W2031311872', 'https://openalex.org/W2036454015', 'https://openalex.org/W2041870050', 'https://openalex.org/W2042678233', 'https://openalex.org/W2043103898', 'https://openalex.org/W2044621914', 'https://openalex.org/W2047964658', 'https://openalex.org/W2048854265', 'https://openalex.org/W2050756511', 'https://openalex.org/W2053266732', 'https://openalex.org/W206172689', 'https://openalex.org/W2062734109', 'https://openalex.org/W2062839391', 'https://openalex.org/W2063712274', 'https://openalex.org/W2065763578', 'https://openalex.org/W2069123478', 'https://openalex.org/W2071097236', 'https://openalex.org/W2073378718', 'https://openalex.org/W2085196275', 'https://openalex.org/W2096459479', 'https://openalex.org/W2097166849', 'https://openalex.org/W2103700658', 'https://openalex.org/W2107522704', 'https://openalex.org/W2114471259', 'https://openalex.org/W2123622204', 'https://openalex.org/W2137798697', 'https://openalex.org/W2138565208', 'https://openalex.org/W2139090396', 'https://openalex.org/W2141606671', 'https://openalex.org/W2148924156', 'https://openalex.org/W2156542195', 'https://openalex.org/W2159013900', 'https://openalex.org/W2161764655', 'https://openalex.org/W2162347651', 'https://openalex.org/W2166278530', 'https://openalex.org/W2167344451', 'https://openalex.org/W2168597484', 'https://openalex.org/W2395461310', 'https://openalex.org/W2404086900', 'https://openalex.org/W2465723300', 'https://openalex.org/W2822764381', 'https://openalex.org/W4234644287'], 'related_works': ['https://openalex.org/W4205106225', 'https://openalex.org/W3174779094', 'https://openalex.org/W2092615839', 'https://openalex.org/W2078068721', 'https://openalex.org/W2067253151', 'https://openalex.org/W1997135566', 'https://openalex.org/W1986169335', 'https://openalex.org/W1978883012', 'https://openalex.org/W1965064962', 'https://openalex.org/W1004292963'], 'abstract_inverted_index': {'Perioperative': [0], 'bleeding': [1, 35], 'is': [2, 10, 47, 195], 'a': [3, 81, 96, 127, 158], 'cause': [4], 'of': [5, 15, 25, 45, 63, 110, 121, 130, 146, 151, 160, 186, 201], 'major': [6], 'blood': [7], 'loss': [8], 'and': [9, 18, 41, 77, 87, 106], 'associated': [11], 'with': [12, 157, 180], 'increased': [13], 'rates': [14], 'postoperative': [16], 'morbidity': [17], 'mortality.': [19], 'To': [20, 192], 'combat': [21], 'this,': [22], 'antifibrinolytic': [23], 'inhibitors': [24, 90, 145], 'the': [26, 48, 108, 196], 'serine': [27, 51, 65], 'protease': [28, 52], 'plasmin': [29, 89, 122, 156, 202], 'are': [30], 'commonly': [31], 'used': [32, 44, 95], 'to': [33, 61, 68, 84, 100, 125, 184], 'reduce': [34], 'during': [36], 'surgery.': [37], 'The': [38, 116, 148], 'most': [39, 149, 197], 'effective': [40], 'previously': [42, 134], 'widely': [43], 'these': [46, 141], 'broad': [49], 'range': [50], 'inhibitor': [53, 200], 'aprotinin.': [54, 191], 'However,': [55], 'adverse': [56], 'clinical': [57], 'outcomes': [58], 'have': [59], 'led': [60], 'use': [62], 'alternative': [64], 'lysine': [66], 'analogues': [67], 'inhibit': [69], 'plasmin.': [70, 147], 'These': [71], 'compounds': [72], 'suffer': [73], 'from': [74], 'low': [75], 'selectivity': [76, 166, 205], 'binding': [78, 119], 'affinity.': [79], 'Consequently,': [80], 'concerted': [82], 'effort': [83], 'discover': [85], 'potent': [86, 111, 150, 198], 'selective': [88], 'has': [91], 'developed.': [92], 'This': [93], 'study': [94], 'noncombinatorial': [97], 'peptide': [98, 199], 'library': [99], 'define': [101], "plasmin's": [102], 'extended': [103], 'substrate': [104, 118], 'specificity': [105], 'guide': [107], 'design': [109], 'transition': [112], 'state': [113], 'analogue': [114], 'inhibitors.': [115], 'various': [117], 'sites': [120], 'were': [123], 'found': [124], 'exhibit': [126], 'higher': [128], 'degree': [129], 'cooperativity': [131], 'than': [132], 'had': [133], 'been': [135], 'appreciated.': [136], 'Peptide': [137], 'sequences': [138], 'capitalizing': [139], 'on': [140], 'features': [142], 'produced': [143], 'high-affinity': [144], 'these,': [152], 'Lys-Met(sulfone)-Tyr-Arg-H': [153], '[KM(O(2))YR-H],': [154], 'inhibited': [155], 'K(i)': [159], '3.1': [161], 'nM': [162, 172, 188], 'while': [163], 'maintaining': [164], '25-fold': [165], 'over': [167], 'plasma': [168, 207], 'kallikrein.': [169], 'Furthermore,': [170], '125': [171], '(0.16': [173], 'μg/mL)': [174, 190], 'KM(O(2))YR-H': [175], 'attenuated': [176], 'fibrinolysis': [177], 'in': [178], 'vitro': [179], 'an': [181, 212], 'efficacy': [182], 'similar': [183], 'that': [185, 203], '15': [187], '(0.20': [189], 'date,': [193], 'this': [194, 210], 'exhibits': [204], 'against': [206], 'kallikrein,': [208], 'making': [209], 'compound': [211], 'attractive': [213], 'candidate': [214], 'for': [215], 'further': [216], 'therapeutic': [217], 'development.': [218]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2094165198', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 3}, {'year': 2018, 'cited_by_count': 6}, {'year': 2017, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 4}, {'year': 2015, 'cited_by_count': 4}, {'year': 2014, 'cited_by_count': 2}, {'year': 2013, 'cited_by_count': 2}, {'year': 2012, 'cited_by_count': 5}], 'updated_date': '2024-12-13T10:25:52.746228', 'created_date': '2016-06-24'}