Title: QT interval prolongation predicts cardiovascular mortality in an apparently healthy population.
Abstract: HomeCirculationVol. 84, No. 4QT interval prolongation predicts cardiovascular mortality in an apparently healthy population. Free AccessAbstractPDF/EPUBAboutView PDFSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toFree AccessAbstractPDF/EPUBQT interval prolongation predicts cardiovascular mortality in an apparently healthy population. E G Schouten, J M Dekker, P Meppelink, F J Kok, J P Vandenbroucke and J Pool E G SchoutenE G Schouten Department of Epidemiology and Public Health, Agricultural University Wageningen, The Netherlands. , J M DekkerJ M Dekker Department of Epidemiology and Public Health, Agricultural University Wageningen, The Netherlands. , P MeppelinkP Meppelink Department of Epidemiology and Public Health, Agricultural University Wageningen, The Netherlands. , F J KokF J Kok Department of Epidemiology and Public Health, Agricultural University Wageningen, The Netherlands. , J P VandenbrouckeJ P Vandenbroucke Department of Epidemiology and Public Health, Agricultural University Wageningen, The Netherlands. and J PoolJ Pool Department of Epidemiology and Public Health, Agricultural University Wageningen, The Netherlands. Originally published1 Oct 1991https://doi.org/10.1161/01.CIR.84.4.1516Circulation. 1991;84:1516–1523AbstractBACKGROUNDIn myocardial infarction patients, heart rate-adjusted QT interval (QTc), an electrocardiographic indicator of sympathetic balance, is prognostic for survival.METHODS AND RESULTSIn a 28-year follow-up, the association between QTc and all-cause, cardiovascular, and ischemic heart disease mortality was studied in a population of 3,091 apparently healthy Dutch civil servants and their spouses, aged 40-65 years, who participated in a medical examination during 1953-1954. Moderate (QTc, 420-440 msec) and extensive (QTc, more than 440 msec) QTc prolongations significantly predict all-cause mortality during the first 15 years among men (adjusted respective relative risks [RRs], 1.5 and 1.7) and among women (RRs, 1.7 and 1.6). In men, cardiovascular (RRs, 1.6 and 1.8) and ischemic heart disease mortality (RRs, 1.8 and 2.1) mainly account for this association. In women, the association cannot be attributed specifically to cardiovascular and ischemic heart disease mortality. RRs for a subpopulation without any sign of heart disease at baseline are similar. The same is observed for QTc prolongation after light exercise, although in this situation most associations are not statistically significant, probably because of smaller numbers in the QTc prolongation categories.CONCLUSIONSOur results suggest that QTc contributes independently to cardiovascular risk. If autonomic imbalance is an important mechanism, it might be speculated that changes in life-style (e.g., with regard to physical exercise and smoking) may have a preventive impact. eLetters(0) eLetters should relate to an article recently published in the journal and are not a forum for providing unpublished data. Comments are reviewed for appropriate use of tone and language. Comments are not peer-reviewed. Acceptable comments are posted to the journal website only. 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Sign In to Submit a Response to This Article Previous Back to top Next FiguresReferencesRelatedDetailsCited By Ahn S, Lee J, Yun M, Han J, Kim S, Lee S, Park M, Park K, Kang D, Kim J and Kwon S (2023) Corrected QTc interval combined with troponin value and mortality in acute ischemic stroke, Frontiers in Cardiovascular Medicine, 10.3389/fcvm.2023.1253871, 10 Dai M, Yan Y, Wang L, Zhao C, Wang D and Jiang J (2023) Characteristics of Electrocardiogram Findings in Fulminant Myocarditis, Journal of Cardiovascular Development and Disease, 10.3390/jcdd10070280, 10:7, (280) Chang Y, Tzeng I, Jang S, Liu K, Hsieh C, Chou H, Yeh K and Huang H (2023) Association between corrected QT interval and long-term cardiovascular outcomes in elderly patients who had undergone endovascular therapy for lower extremity arterial disease, Frontiers in Cardiovascular Medicine, 10.3389/fcvm.2023.1103520, 10 Miró Ò, Aguiló O, Trullàs J, Gil V, Espinosa B, Jacob J, Herrero-Puente P, Tost J, López-Grima M, Comas P, Bibiano C, Llauger L, Martin Mojarro E, López-Díez M, Núñez J, Rafique Z, Keene K, Peacock F, Lopez-Ayala P, Mueller C, Montero Pérez-Barquero M, Mont L, Llorens P, Fuentes M, Gil C, Alonso H, Pérez-Llantada E, Martín-Sánchez F, Llopis García G, Cadenas M, Escoda R, Aguiló S, Sánchez C, Millán J, Pavón J, Noval A, López-Grima M, Valero A, Juan M, Aguirre A, Pedragosa M, Mínguez Masó S, Alonso M, Ruiz F, Franco J, Mecina A, Berenguer M, Donea R, Sánchez Ramón S, Carbajosa Rodríguez V, Piñera P, Sánchez Nicolás J, Torres Garate R, Alquézar-Arbé A, Rizzi M, Herrera S, Roset A, Cabello I, Haro A, Richard F, Álvarez Pérez J, Herrero Puente P, Vázquez Álvarez J, Prieto García B, García García M, Sánchez González M, Javaloyes P, Jiménez I, Hernández N, Gil A, Molina F, García T, Andueza J, Romero R, Ruíz M, Calvache R, Lorca Serralta M, Calderón Jave L, Amores Arriaga B, Sierra Bergua B, Martín Mojarro E, Alarcón Jiménez B, Travería Bécquer L, Burillo G, Llauger García L, Corominas LaSalle G, Agüera Urbano C, García Soto A, Delgado Padial E, Soy Ferrer E, Adroher Múñoz M, Garrido J, Lucas-Imbernón F, Gaya R, Bibiano C, Mir M, Rodríguez B, Carballo J, Rodríguez-Adrada E, Rodríguez Miranda B, Vicente Martín M, Coma Casanova P and Espinach Alvarós J (2023) QT interval and short-term outcome in acute heart failure, Clinical Research in Cardiology, 10.1007/s00392-023-02173-9 Iqbal M, Febrianora M, Putra I, Pramudyo M and Achmad C (2023) Incidence of Myocarditis Associated with Diphtheria, Tetanus, and Pertussis Vaccine: A Rare Case Series, International Journal of Angiology, 10.1055/s-0043-1767740 Wang C, Mao M, Han X, Hou T, Wang X, Han Q, Dong Y, Liu R, Cong L, Liu C, Imahori Y, Vetrano D, Wang Y, Du Y and Qiu C Associations of Cardiac Ventricular Repolarization with Serum Adhesion Molecules and Cognitive Function in Older Adults: The MIND-China Study, Journal of Alzheimer's Disease, 10.3233/JAD-220874, 92:1, (273-283) Johannsdottir H, Gudmundsdottir I, Karason S and Sigurdsson M (2022) Association between pre‐operative prolonged corrected QT interval and all‐cause mortality after non‐cardiac surgery, Acta Anaesthesiologica Scandinavica, 10.1111/aas.14178, 67:3, (284-292), Online publication date: 1-Mar-2023. 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