Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2094099537', 'doi': 'https://doi.org/10.1093/jb/mvg101', 'title': 'Basis of a High-Throughput Method for Nuclear Receptor Ligands', 'display_name': 'Basis of a High-Throughput Method for Nuclear Receptor Ligands', 'publication_year': 2003, 'publication_date': '2003-06-01', 'ids': {'openalex': 'https://openalex.org/W2094099537', 'doi': 'https://doi.org/10.1093/jb/mvg101', 'mag': '2094099537', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/12869536'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1093/jb/mvg101', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S184547178', 'display_name': 'The Journal of Biochemistry', 'issn_l': '0021-924X', 'issn': ['0021-924X', '1756-2651'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5113002201', 'display_name': 'T. Kanayama', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I98285908', 'display_name': 'Osaka University', 'ror': 'https://ror.org/035t8zc32', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I98285908']}], 'countries': ['JP'], 'is_corresponding': True, 'raw_author_name': 'T. Kanayama', 'raw_affiliation_strings': ['Laboratory of Environmental Biochemistry, Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamada-oka, Suita, Osaka, 565-0871'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of Environmental Biochemistry, Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamada-oka, Suita, Osaka, 565-0871', 'institution_ids': ['https://openalex.org/I98285908']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5113002201'], 'corresponding_institution_ids': ['https://openalex.org/I98285908'], 'apc_list': {'value': 3000, 'currency': 'USD', 'value_usd': 3000, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 0.907, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 37, 'citation_normalized_percentile': {'value': 0.611957, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 90, 'max': 91}, 'biblio': {'volume': '133', 'issue': '6', 'first_page': '791', 'last_page': '797'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11559', 'display_name': 'Retinoids in leukemia and cellular processes', 'score': 0.999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11559', 'display_name': 'Retinoids in leukemia and cellular processes', 'score': 0.999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10756', 'display_name': 'Estrogen and related hormone effects', 'score': 0.9988, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T13991', 'display_name': 'Nuclear Receptors and Signaling', 'score': 0.9919, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/pelp-1', 'display_name': 'PELP-1', 'score': 0.74045944}], 'concepts': [{'id': 'https://openalex.org/C63932345', 'wikidata': 'https://www.wikidata.org/wiki/Q422500', 'display_name': 'Nuclear receptor', 'level': 4, 'score': 0.83647317}, {'id': 'https://openalex.org/C84750089', 'wikidata': 'https://www.wikidata.org/wiki/Q21130793', 'display_name': 'PELP-1', 'level': 5, 'score': 0.74045944}, {'id': 'https://openalex.org/C195598365', 'wikidata': 'https://www.wikidata.org/wiki/Q14914583', 'display_name': 'Nuclear receptor coactivator 1', 'level': 5, 'score': 0.71977353}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.64816713}, {'id': 'https://openalex.org/C77445288', 'wikidata': 'https://www.wikidata.org/wiki/Q637488', 'display_name': 'Coactivator', 'level': 4, 'score': 0.57720864}, {'id': 'https://openalex.org/C203966977', 'wikidata': 'https://www.wikidata.org/wiki/Q14914599', 'display_name': 'Nuclear receptor coactivator 3', 'level': 5, 'score': 0.564181}, {'id': 'https://openalex.org/C124170894', 'wikidata': 'https://www.wikidata.org/wiki/Q14914591', 'display_name': 'Nuclear receptor coactivator 2', 'level': 5, 'score': 0.55239326}, {'id': 'https://openalex.org/C123894998', 'wikidata': 'https://www.wikidata.org/wiki/Q425158', 'display_name': 'Fusion protein', 'level': 4, 'score': 0.4890624}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.48709583}, {'id': 'https://openalex.org/C86339819', 'wikidata': 'https://www.wikidata.org/wiki/Q407384', 'display_name': 'Transcription factor', 'level': 3, 'score': 0.48588437}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.46057013}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.42825583}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.38356125}, {'id': 'https://openalex.org/C40767141', 'wikidata': 'https://www.wikidata.org/wiki/Q285697', 'display_name': 'Recombinant DNA', 'level': 3, 'score': 0.15744174}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.13145125}], 'mesh': [{'descriptor_ui': 'D000469', 'descriptor_name': 'Alkaline Phosphatase', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D003065', 'descriptor_name': 'Coenzyme A', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D005982', 'descriptor_name': 'Glutathione Transferase', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D018160', 'descriptor_name': 'Receptors, Cytoplasmic and Nuclear', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D014157', 'descriptor_name': 'Transcription Factors', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000469', 'descriptor_name': 'Alkaline Phosphatase', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D000469', 'descriptor_name': 'Alkaline Phosphatase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001681', 'descriptor_name': 'Biological Assay', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003065', 'descriptor_name': 'Coenzyme A', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D003065', 'descriptor_name': 'Coenzyme A', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004353', 'descriptor_name': 'Drug Evaluation, Preclinical', 'qualifier_ui': 'Q000379', 'qualifier_name': 'methods', 'is_major_topic': False}, {'descriptor_ui': 'D004353', 'descriptor_name': 'Drug Evaluation, Preclinical', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004926', 'descriptor_name': 'Escherichia coli', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004926', 'descriptor_name': 'Escherichia coli', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D005982', 'descriptor_name': 'Glutathione Transferase', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D005982', 'descriptor_name': 'Glutathione Transferase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008024', 'descriptor_name': 'Ligands', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051958', 'descriptor_name': 'Nuclear Receptor Coactivator 2', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011485', 'descriptor_name': 'Protein Binding', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018160', 'descriptor_name': 'Receptors, Cytoplasmic and Nuclear', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D018160', 'descriptor_name': 'Receptors, Cytoplasmic and Nuclear', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D018160', 'descriptor_name': 'Receptors, Cytoplasmic and Nuclear', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011993', 'descriptor_name': 'Recombinant Fusion Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D011993', 'descriptor_name': 'Recombinant Fusion Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D011993', 'descriptor_name': 'Recombinant Fusion Proteins', 'qualifier_ui': 'Q000302', 'qualifier_name': 'isolation & purification', 'is_major_topic': False}, {'descriptor_ui': 'D011993', 'descriptor_name': 'Recombinant Fusion Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012680', 'descriptor_name': 'Sensitivity and Specificity', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014157', 'descriptor_name': 'Transcription Factors', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D014157', 'descriptor_name': 'Transcription Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015262', 'descriptor_name': 'Xenobiotics', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D015262', 'descriptor_name': 'Xenobiotics', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D015262', 'descriptor_name': 'Xenobiotics', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1093/jb/mvg101', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S184547178', 'display_name': 'The Journal of Biochemistry', 'issn_l': '0021-924X', 'issn': ['0021-924X', '1756-2651'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/12869536', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'score': 0.65, 'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 31, 'referenced_works': ['https://openalex.org/W120220131', 'https://openalex.org/W1493268813', 'https://openalex.org/W1501286679', 'https://openalex.org/W1964186830', 'https://openalex.org/W1977873926', 'https://openalex.org/W1979243778', 'https://openalex.org/W1981022538', 'https://openalex.org/W1981873124', 'https://openalex.org/W1985396274', 'https://openalex.org/W1985865142', 'https://openalex.org/W1987438736', 'https://openalex.org/W1989444478', 'https://openalex.org/W1990529844', 'https://openalex.org/W2013915546', 'https://openalex.org/W2042901562', 'https://openalex.org/W2050743111', 'https://openalex.org/W2068113812', 'https://openalex.org/W2079080809', 'https://openalex.org/W2079694858', 'https://openalex.org/W2101738855', 'https://openalex.org/W2106819517', 'https://openalex.org/W2113456624', 'https://openalex.org/W2134567873', 'https://openalex.org/W2139717510', 'https://openalex.org/W2140087383', 'https://openalex.org/W2141662437', 'https://openalex.org/W2141686420', 'https://openalex.org/W2143241514', 'https://openalex.org/W2156693006', 'https://openalex.org/W2172256092', 'https://openalex.org/W306298619'], 'related_works': ['https://openalex.org/W3042507822', 'https://openalex.org/W2165762583', 'https://openalex.org/W2159762082', 'https://openalex.org/W2137658990', 'https://openalex.org/W2077994082', 'https://openalex.org/W2073133361', 'https://openalex.org/W2048600164', 'https://openalex.org/W2043852388', 'https://openalex.org/W2030148320', 'https://openalex.org/W1972158913'], 'abstract_inverted_index': {'Journal': [0, 82], 'Article': [1], 'Basis': [2], 'of': [3, 83], 'a': [4], 'High-Throughput': [5], 'Method': [6], 'for': [7, 18, 35, 52, 69], 'Nuclear': [8], 'Receptor': [9], 'Ligands': [10], 'Get': [11], 'access': [12], 'Tomohiko': [13, 15], 'Kanayama,': [14], 'Kanayama': [16], 'Search': [17, 34, 51, 68], 'other': [19, 36, 53, 70], 'works': [20, 37, 54, 71], 'by': [21, 38, 55, 72], 'this': [22, 39, 56, 73], 'author': [23, 40, 57, 74], 'on:': [24, 41, 58, 75], 'Oxford': [25, 42, 59, 76], 'Academic': [26, 43, 60, 77], 'PubMed': [27, 44, 61, 78], 'Google': [28, 45, 62, 79], 'Scholar': [29, 46, 63, 80], 'Satoru': [30, 32], 'Mamiya,': [31], 'Mamiya': [33], 'Tsutomu': [47, 49], 'Nishihara,': [48], 'Nishihara': [50], 'Jun-ichi': [64, 66], 'Nishikawa': [65, 67], 'The': [81], 'Biochemistry,': [84], 'Volume': [85], '133,': [86], 'Issue': [87], '6,': [88], 'June': [89, 96], '2003,': [90], 'Pages': [91], '791–797,': [92], 'https://doi.org/10.1093/jb/mvg101': [93], 'Published:': [94], '01': [95], '2003': [97]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2094099537', 'counts_by_year': [{'year': 2021, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 2}, {'year': 2013, 'cited_by_count': 4}, {'year': 2012, 'cited_by_count': 2}], 'updated_date': '2024-12-10T21:12:16.792871', 'created_date': '2016-06-24'}