Title: Semen analysis in Hodgkin's disease before the onset of treatment
Abstract: CancerVolume 57, Issue 10 p. 1986-1987 ArticleFree Access Semen analysis in Hodgkin's disease before the onset of treatment Dominique Marmor MD, Corresponding Author Dominique Marmor MD Laboratoire d'Embryologie Pathologique et de Cytogénétique, Pr Ch Roux, Hǒpital Saint-Antoine, ParisLaboratoire d'Embryologie, Chu Saint-Antoine, 27, rue Chaligny, 75012 Paris, France===Search for more papers by this authorElisabeth Elefant MD, Elisabeth Elefant MD Laboratoire d'Embryologie Pathologique et de Cytogénétique, Pr Ch Roux, Hǒpital Saint-Antoine, ParisSearch for more papers by this authorCaroline Dauchez MD, Caroline Dauchez MD Laboratoire d'Embryologie Pathologique et de Cytogénétique, Pr Ch Roux, Hǒpital Saint-Antoine, ParisSearch for more papers by this authorCharles Roux MD, Charles Roux MD Laboratoire d'Embryologie Pathologique et de Cytogénétique, Pr Ch Roux, Hǒpital Saint-Antoine, ParisSearch for more papers by this author Dominique Marmor MD, Corresponding Author Dominique Marmor MD Laboratoire d'Embryologie Pathologique et de Cytogénétique, Pr Ch Roux, Hǒpital Saint-Antoine, ParisLaboratoire d'Embryologie, Chu Saint-Antoine, 27, rue Chaligny, 75012 Paris, France===Search for more papers by this authorElisabeth Elefant MD, Elisabeth Elefant MD Laboratoire d'Embryologie Pathologique et de Cytogénétique, Pr Ch Roux, Hǒpital Saint-Antoine, ParisSearch for more papers by this authorCaroline Dauchez MD, Caroline Dauchez MD Laboratoire d'Embryologie Pathologique et de Cytogénétique, Pr Ch Roux, Hǒpital Saint-Antoine, ParisSearch for more papers by this authorCharles Roux MD, Charles Roux MD Laboratoire d'Embryologie Pathologique et de Cytogénétique, Pr Ch Roux, Hǒpital Saint-Antoine, ParisSearch for more papers by this author First published: 15 May 1986 https://doi.org/10.1002/1097-0142(19860515)57:10<1986::AID-CNCR2820571017>3.0.CO;2-WCitations: 44AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat Abstract A spermogram was performed before treatment in 57 young patients with Hodgkin's disease. The mean results were normal, and similar to those reported in fertile populations. Nineteen patients had an abnormal spermogram; 12 of these men had had fever recently or were febrile at the time of the exam. When the temperature was below 38.5°C, there was only asthenospermia. With a higher temperature, semen anomalies were more severe, with oligoasthenospermia or even azoospermia. Only five febrile men had a normal spermogram, and all had slight fevers. Therefore, semen anomalies noted in about one third of patients with Hodgkin's disease are probably not due to a disease specific gonadal alteration, but can be attributed to fever which gonadal effects have been recognized for a long time and are well-documented. References 1 Chapman RM, Sutcliffe SB, Rees LH, Edwards CRW, Malpas JS. Cyclical combination chemotherapy and gonadal function. Lancet 1979; 1: 285–289. 10.1016/S0140-6736(79)90701-3 CASPubMedWeb of Science®Google Scholar 2 De Vita VT. The consequences of chemotherapy of Hodgkin's disease. Cancer 1981; 47: 1–13. 10.1002/1097-0142(19810101)47:1<1::AID-CNCR2820470102>3.0.CO;2-2 PubMedWeb of Science®Google Scholar 3 Marmor D, Pinon-Netter C, Netter A. Effects of chemotherapy on testicular function. Int J Androl 1982; (Suppl) 5: 191–197. 10.1111/j.1365-2605.1982.tb00314.x CASPubMedWeb of Science®Google Scholar 4 Waxman J. Gonadal function in Hodgkin's disease: Long-term follow-up of chemotherapy. Br J Med 1982; 285: 1612–1613. 10.1136/bmj.285.6355.1612 CASPubMedWeb of Science®Google Scholar 5 Whitehead E, Shalet SM, Blackledge G, Todd I, Crowther D, Beardwell CG. The effects of Hodgkin's disease and combination chemotherapy on gonadal function in the adult male. Cancer 1982; 49: 418–422. 10.1002/1097-0142(19820201)49:3<418::AID-CNCR2820490304>3.0.CO;2-A CASPubMedWeb of Science®Google Scholar 6 Chapman RM, Sutcliffe SB, Malpas JS. Male gonadal dysfunction in Hodgkin's disease: A prospective study. JAMA 1981; 245: 1323–1328. 10.1001/jama.1981.03310380027020 CASPubMedWeb of Science®Google Scholar 7 Vigersky RA, Chapman RM, Berenberg J, Glass AR. Testicular dysfunction in untreated Hodgkin's disease. Am J Med 1982; 73: 482–486. 10.1016/0002-9343(82)90325-4 CASPubMedWeb of Science®Google Scholar 8 Jouannet P, Soufir JC, Ducot B, Spira A, Soumah A, Marson J. Semen parameters and fertility. Ann Endocrinol 1981; 42: 416–422. CASWeb of Science®Google Scholar 9 Andrieu JM, Masson D, Gourmel B, Czyglik F, Bernard J. Fertility of young men with Hodgkin's disease, before and after chemotherapy. Nouv Presse Med 1981; 10: 2085–2088. CASPubMedWeb of Science®Google Scholar 10 Van De Mark NL, Free JM. Temperature effects. In: AD Johnson, WR Gones, NL Van De Mark, eds. The Testis: III. Influencing factors. New York: Academic Press, 1970; 233–312. Google Scholar 11 Heller RE. New evidence for the function of the scrotum. Physiol Zool 1929; 2: 9. 10.1086/physzool.2.1.30151061 Google Scholar 12 Glover TD. Spermatozoa from isolated cauda epididymis of rabbits and some effects of experimental cryptorchidism. J Reprod Fertil 1960; 1: 121–129. 10.1530/jrf.0.0010121 Web of Science®Google Scholar 13 Procope BJ. Effects of repeated increase of body temperature on human sperm cells. Int J Fertil 1965; 10: 333–339. CASPubMedWeb of Science®Google Scholar 14 Mac Leod J, Hotchkiss RS. The effect of hyperpyrexia upon spermatozoa counts in men. Endocrinology 1941; 28: 780–784. 10.1210/endo-28-5-780 Google Scholar 15 Brindley GS. Deep scrotal temperature and the effects on it of clothing, air temperature, activity, posture and paraplegia. Br J Urol 1982; 54: 49–55. 10.1111/j.1464-410X.1982.tb13510.x PubMedWeb of Science®Google Scholar 16 Levier RR, Spaziani E. The influence of temperature on steroïdogenesis in the rat testis. J Exptl Zool 1968; 169: 113–120. 10.1002/jez.1401690113 CASPubMedWeb of Science®Google Scholar Citing Literature Volume57, Issue1015 May 1986Pages 1986-1987 ReferencesRelatedInformation