Publication Information

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'https://openalex.org/W2051337563', 'https://openalex.org/W1971782741'], 'abstract_inverted_index': {'To': [0, 205, 1724, 3216, 4302], 'gain': [1, 206], 'further': [2, 207], 'insight': [3, 208], 'into': [4, 209, 1565, 2241], 'the': [5, 9, 28, 31, 35, 41, 61, 72, 78, 81, 85, 88, 94, 98, 102, 106, 113, 117, 121, 126, 153, 157, 166, 171, 176, 180, 210, 214, 233, 236, 240, 246, 266, 277, 283, 286, 290, 293, 299, 303, 307, 311, 318, 322, 326, 331, 358, 362, 371, 376, 381, 385, 544, 555, 562, 828, 835, 846, 850, 877, 883, 886, 901, 923, 930, 941, 947, 1021, 1024, 1027, 1031, 1035, 1163, 1174, 1194, 1200, 1233, 1251, 1254, 1258, 1261, 1266, 1270, 1303, 1307, 1310, 1313, 1320, 1324, 1408, 1417, 1428, 1432, 1442, 1453, 1462, 1527, 1566, 1596, 1697, 1786, 1872, 1891, 1901, 2018, 2022, 2087, 2092, 2095, 2104, 2150, 2158, 2216, 2326, 2342, 2345, 2516, 2540, 2593, 2603, 2632, 2744, 2766, 2810, 2823, 2847, 2864, 2869, 2931, 2946, 3108, 3124, 3128, 3135, 3141, 3153, 3163, 3168, 3179, 3185, 3190, 3218, 3225, 3252, 3258, 3265, 3270, 3273, 3283, 3290, 3294, 3317, 3324, 3328, 3335, 3343, 3346, 3517, 3533, 3539, 3548, 3554, 3563, 3580, 3584, 3588, 3597, 3600, 3612, 3623, 3634, 3639, 3644, 3720, 3768, 3779, 3793, 3839, 3862, 3872, 3891, 3901, 3932, 3936, 3965, 4038, 4044, 4060, 4070, 4075, 4085, 4108, 4116, 4125, 4129, 4141, 4171, 4183, 4186, 4193, 4199, 4247, 4255, 4273, 4305, 4309, 4314, 4316, 4359, 4386, 4410, 4439, 4443, 4486, 4489, 4492, 4498, 4501, 4506, 4513, 4540], 'interactions': [6, 26, 104, 185, 211, 231, 309, 390, 1304, 1398, 3126, 3331], 'involved': [7, 75, 169, 212, 280, 374, 1339, 3142], 'in': [8, 23, 76, 87, 93, 133, 170, 213, 228, 281, 292, 298, 338, 375, 430, 834, 891, 909, 1020, 1046, 1133, 1334, 1425, 1452, 1650, 1709, 1994, 2058, 2086, 2188, 2215, 2299, 2319, 2387, 2397, 2410, 2485, 2554, 2580, 2611, 2624, 2731, 2879, 2940, 3015, 3037, 3114, 3132, 3146, 3162, 3178, 3224, 3235, 3257, 3528, 3544, 3569, 3625, 3800, 3868, 3894, 4110, 4149, 4182, 4201, 4267], 'allosteric': [10, 148, 173, 215, 353, 378, 1169], 'transition': [11, 216, 1440, 2106, 4196, 4393, 4483], 'of': [12, 34, 64, 71, 80, 97, 101, 109, 116, 142, 165, 175, 217, 239, 269, 276, 285, 302, 306, 314, 321, 347, 370, 380, 420, 436, 447, 452, 474, 561, 570, 573, 788, 827, 838, 845, 882, 922, 954, 1023, 1116, 1128, 1166, 1232, 1237, 1253, 1260, 1265, 1302, 1323, 1392, 1770, 1775, 1847, 2051, 2094, 2175, 2180, 2213, 2220, 2230, 2335, 2380, 2400, 2413, 2474, 2477, 2546, 2549, 2615, 2653, 2657, 2692, 2717, 2793, 2803, 2830, 2834, 2849, 2861, 2863, 2961, 3004, 3085, 3121, 3123, 3134, 3140, 3189, 3220, 3230, 3251, 3269, 3286, 3293, 3320, 3327, 3334, 3345, 3498, 3516, 3559, 3566, 3609, 3627, 3636, 3767, 3778, 3792, 3842, 3875, 3883, 3900, 3934, 3964, 4040, 4074, 4115, 4124, 4143, 4185, 4203, 4215, 4243, 4251, 4272, 4289, 4308, 4326, 4389, 4442, 4448, 4488, 4500, 4515, 4522, 4529, 4534, 4539], 'DnaK': [13, 218, 1238, 1393, 1446, 1463, 1502, 1599, 2182, 3980, 4216, 4245, 4253, 4291, 4450], 'we': [14, 219, 1387], 'have': [15, 44, 125, 220, 249, 330, 581, 4457], 'characterized': [16, 221, 4434], 'wild-type': [17, 222, 1600, 2181, 4360], '(wt)': [18, 223], 'protein': [19, 224, 440, 448, 453, 1325, 1781, 2004, 2015, 2231, 2627, 2821, 3717, 3725, 3819, 3845, 4087, 4310, 4361, 4517], 'and': [20, 39, 67, 112, 159, 194, 225, 244, 272, 317, 364, 399, 445, 450, 484, 548, 557, 812, 905, 907, 917, 936, 943, 962, 1026, 1184, 1404, 1410, 1444, 1493, 1521, 1535, 1543, 1555, 1592, 1601, 1606, 1646, 1653, 1732, 1767, 1785, 1839, 1844, 1850, 1856, 1890, 1905, 1984, 2001, 2012, 2037, 2080, 2157, 2183, 2238, 2260, 2307, 2330, 2332, 2355, 2365, 2371, 2377, 2385, 2409, 2421, 2526, 2532, 2651, 2655, 2663, 2704, 2750, 2782, 2842, 2916, 2923, 2948, 2964, 2966, 2972, 3064, 3069, 3076, 3155, 3170, 3173, 3227, 3289, 3312, 3323, 3502, 3511, 3514, 3530, 3538, 3553, 3594, 3611, 3719, 3736, 3743, 3756, 3808, 3849, 3877, 3890, 3904, 3920, 3959, 4057, 4067, 4097, 4168, 4176, 4241, 4246, 4254, 4275, 4337, 4352, 4369, 4505, 4542], 'three': [21, 226, 1390, 3492, 3613, 4256, 4454], 'mutants': [22, 227, 1391, 1602, 2184, 3614, 3863, 4257, 4339, 4524], 'which': [24, 229, 542, 1203, 1335, 4437], 'ionic': [25, 51, 103, 154, 230, 256, 308, 359, 1397, 3125, 3136, 3222, 3585], 'at': [27, 156, 190, 232, 361, 395, 849, 1088, 1312, 1347, 1401, 1407, 1745, 1760, 1764, 1834, 1875, 1991, 2026, 2047, 2168, 2207, 2234, 2348, 2713, 2893, 2934, 2957, 2970, 3012, 3098, 3099, 3127, 3508, 3587, 3817, 4051, 4154, 4318, 4349, 4394, 4399, 4413], 'interface': [29, 234], 'between': [30, 60, 105, 235, 265, 310, 895, 1399, 1441, 3282, 3316, 3506, 3522, 3535, 3550, 4173], 'two': [32, 237, 475, 896, 913, 2172, 3304, 3499], 'subdomains': [33, 238], 'substrate': [36, 203, 241, 408, 489, 498, 887, 948, 1182, 1190, 1195, 1277, 4119, 4502, 4543], 'binding': [37, 182, 242, 387, 490, 499, 527, 546, 564, 949, 1272, 1705, 1830, 1902, 3348, 3711, 3732, 3757, 3816, 3834, 3937, 4503, 4544], 'domain,': [38, 243, 4491, 4504], 'within': [40, 245, 3596], 'lid': [42, 82, 177, 247, 287, 382, 928, 1025, 1255, 1267, 1308, 1328, 1409, 3191, 3555, 3598], 'subdomain': [43, 158, 248, 363, 551, 848, 903, 921, 1455, 3192, 3296], 'been': [45, 250, 582, 797, 1041, 1242, 4458], 'disrupted.': [46, 251, 3298], 'Our': [47, 150, 252, 355, 1413], 'data': [48, 253, 1750, 1787, 2142, 2628, 2643, 2812, 3822], 'show': [49, 254, 1526, 3599, 3745], 'that': [50, 139, 162, 255, 344, 367, 552, 842, 898, 970, 1118, 1176, 1240, 1305, 1326, 1394, 1416, 1448, 3131, 3249, 3307, 3338, 3495, 3526, 3924, 3976, 4084, 4113, 4153, 4192, 4279, 4288, 4294, 4398, 4409, 4422, 4456, 4528], 'contacts,': [52, 257], 'most': [53, 258, 844, 1234], 'likely': [54, 259], 'forming': [55, 260], 'an': [56, 68, 134, 261, 273, 339, 549, 892, 1168, 2320, 2724, 2858, 3058], 'electrically': [57, 262], 'charged': [58, 263, 2576], 'network,': [59, 264], 'N-terminal': [62, 267, 481, 3160, 3284], 'region': [63, 108, 168, 268, 313, 373], 'helix': [65, 110, 270, 315, 944, 955, 1336, 1402, 3147, 3171, 3236, 3287, 3321, 3509, 3536, 3551], 'B': [66, 111, 271, 316, 937, 945, 1337, 1403, 3237, 3288, 3322, 3510, 3537, 3552], 'inner': [69, 274, 3291], 'loop': [70, 275], 'β-sandwich': [73, 278, 902, 931, 3169, 3259, 3295, 3540], 'are': [74, 163, 279, 368, 415, 831, 908, 938, 3332, 3590, 3763, 3774, 3788, 3858, 3879, 3885], 'maintaining': [77, 282], 'position': [79, 284, 1252], 'relative': [83, 288, 1256, 1430], 'to': [84, 289, 417, 1043, 1173, 1199, 1244, 1257, 1275, 1309, 1318, 1341, 1356, 1431, 1594, 1609, 1739, 1870, 1881, 1899, 2044, 2077, 2083, 2102, 2135, 2262, 2267, 2341, 2391, 2435, 2512, 2601, 2685, 2723, 2742, 2747, 2761, 2765, 2779, 3034, 3247, 3341, 3615, 3728, 3825, 3887, 3942, 3975, 4105, 4161, 4287, 4497], 'β-subdomain': [86, 291, 1259, 1311], 'ADP': [89, 294, 1869], 'state': [90, 96, 295, 301, 2874], 'but': [91, 130, 296, 335, 1033], 'not': [92, 124, 297, 329, 1034, 3591, 4297], 'ATP': [95, 300, 1161, 2223, 2917], 'protein.': [99, 136, 304, 341, 2177, 3271], 'Disruption': [100, 305], 'C-terminal': [107, 312, 488, 3176, 3318], 'outer': [114, 319, 3325], 'loops': [115, 320, 897, 915, 3292, 3326], 'β-sandwich,': [118, 323, 541, 942], 'known': [119, 324, 879], 'as': [120, 325, 434, 972, 1573, 1655, 1790, 1864, 1866, 1907, 2441, 2661, 2896, 2976, 3643, 3648, 3866, 4209, 4323, 4355], 'latch,': [122, 327], 'does': [123, 328], 'same': [127, 332, 4061, 4071], 'conformational': [128, 333, 4195], 'consequences': [129, 334], 'results': [131, 151, 336, 356, 1414], 'equally': [132, 337, 3592], 'inactive': [135, 340], 'This': [137, 342, 3149, 3971], 'indicates': [138, 343], 'a': [140, 199, 345, 404, 479, 485, 540, 786, 789, 839, 927, 966, 973, 1134, 1178, 1205, 1422, 1438, 1754, 1882, 1887, 1959, 1965, 2032, 2048, 2059, 2300, 2388, 2486, 2547, 2566, 2612, 2625, 2675, 2686, 2697, 2714, 2755, 2799, 2850, 2854, 2941, 2958, 3094, 3115, 3279, 3309, 3313, 3503, 3628, 3729, 3746, 3764, 3775, 3789, 3801, 3826, 3831, 3897, 3944, 3961, 3979, 4032, 4151, 4212, 4270, 4283, 4324, 4392, 4537], 'variety': [141, 346], 'mechanisms': [143, 348], 'can': [144, 349, 3968], 'inactivate': [145, 350], 'this': [146, 351, 1348, 1385, 3262, 3570, 4139, 4157, 4299], 'complex': [147, 352, 4042, 4127], 'machine.': [149, 354], 'identify': [152, 357], 'contacts': [155, 360, 830, 1030, 3137, 3223, 3586], 'interdomain': [160, 365, 829, 1017], 'interfaces': [161, 366], 'part': [164, 369, 953, 3319, 3333], 'hinge': [167, 372, 1321], 'ATP-induced': [172, 377], 'displacement': [174, 379, 1264], 'away': [178, 383, 1268], 'from': [179, 384, 793, 900, 1269, 1461, 2009, 2041, 2255, 2480, 2759, 3912, 3948, 4485, 4512, 4527], 'peptide': [181, 386, 545, 563, 888, 1029, 1271, 1703, 1776, 2835, 2852, 2947, 2954, 3266, 3347, 3617, 3631, 3645, 4076, 4118, 4145], 'site.': [183, 388, 565], 'These': [184, 389, 3330, 3786, 3856], 'also': [186, 391, 428, 3811, 3922, 4428, 4433], 'stabilize': [187, 392, 1871], 'peptide-Hsp70': [188, 393], 'complexes': [189, 394, 1049], 'physiological': [191, 396], '(37': [192, 397], '°C)': [193, 197, 398, 402], 'stress': [195, 400, 1089, 1876, 4155], '(42': [196, 401], 'temperatures,': [198, 403], 'requirement': [200, 405], 'for': [201, 406, 1208, 1248, 1530, 1538, 1546, 1558, 1778, 2014, 2245, 2407, 2418, 2423, 2428, 2642, 2710, 2868, 2937, 3009, 3723, 3750, 3861, 3916, 3927, 3978, 4031, 4093, 4101, 4107, 4135, 4198, 4205, 4211, 4333, 4358, 4418], 'productive': [202, 407], '(re)folding.': [204, 409], 'The': [410, 537, 919, 933, 951, 1113, 1263, 1773, 1969, 2140, 2294, 2522, 2586, 2637, 2774, 3299, 3487, 3519, 3739, 3804, 3821, 3908, 4122, 4446, 4480, 4519, 4532], 'ubiquitous': [411], 'Hsp70': [412, 471, 792, 884, 1119, 1734, 1780, 1845, 1897, 2203, 2922, 3560, 3581], 'chaperone': [413], 'proteins': [414, 422, 472, 1120, 2204, 3524, 4281, 4420], 'essential': [416, 1045], 'prevent': [418], 'aggregation': [419], 'misfolded': [421], 'under': [423, 2132], 'heat': [424], 'shock': [425], 'conditions.': [426], 'They': [427, 4342], 'participate': [429], 'cellular': [431], 'processes': [432], 'such': [433, 4150], 'folding': [435, 1359, 3164, 3181], 'newly': [437], 'synthesized': [438], 'polypeptides,': [439], 'translocation': [441], 'across': [442], 'membranes,': [443], 'assembly': [444], 'disassembly': [446], 'complexes,': [449], 'refolding': [451], 'aggregates': [454], '(1Mayer': [455, 3350], 'M.P.': [456, 1211, 1280, 3351], 'Bukau': [457, 1218, 1287, 1627, 3352], 'B.': [458, 1219, 1288, 1628, 3148, 3353], 'Cell': [459, 3354], 'Mol.': [460, 629, 775, 816, 860, 1800, 2118, 3355, 3397, 3680, 4470], 'Life': [461, 3356], 'Sci.': [462, 738, 754, 1007, 3357, 3698], '2005;': [463, 818, 862, 1821, 1945, 3358, 3399], '62:': [464, 3359], '670-684Crossref': [465, 3360], 'PubMed': [466, 594, 611, 634, 655, 678, 698, 724, 742, 761, 780, 821, 870, 993, 1011, 1069, 1082, 1108, 1157, 1226, 1295, 1379, 1485, 1516, 1587, 1640, 1678, 1824, 1928, 1948, 2123, 2286, 2463, 2910, 2998, 3211, 3361, 3384, 3407, 3429, 3463, 3482, 3668, 3705, 4002, 4024, 4234, 4381, 4475], 'Scopus': [467, 595, 612, 635, 656, 679, 699, 725, 743, 762, 781, 822, 871, 994, 1012, 1070, 1083, 1109, 1227, 1296, 1380, 1486, 1517, 1588, 1641, 1805, 1825, 1929, 1949, 2124, 2287, 2464, 2503, 2911, 2999, 3212, 3362, 3385, 3408, 3430, 3464, 3483, 3669, 3685, 3706, 4003, 4025, 4235, 4476], '(2091)': [468, 3363], 'Google': [469, 597, 614, 637, 658, 681, 701, 727, 745, 764, 783, 824, 873, 996, 1014, 1072, 1085, 1111, 1158, 1229, 1298, 1382, 1488, 1519, 1590, 1643, 1679, 1807, 1827, 1931, 1951, 2126, 2289, 2466, 2505, 2913, 3001, 3214, 3364, 3387, 3410, 3432, 3466, 3485, 3671, 3687, 3708, 4005, 4027, 4237, 4382, 4478], 'Scholar).': [470, 784, 825, 874, 1015, 1112, 1159, 1230, 1299, 1383, 1489, 1644, 1691, 1828, 1952, 2127, 2506, 2914, 3002, 3215, 3486, 3709, 4028, 4238, 4383, 4479], 'consist': [473], 'major': [476], 'structural': [477, 575, 1439, 1450, 3226, 4300], 'domains:': [478], 'conserved': [480, 3578], 'ATPase': [482, 1164, 1873, 2872, 2875, 4490, 4541], 'domain': [483, 491, 1165, 1874], 'more': [486], 'variable': [487, 2664], '(SBD).': [492], '4The': [493], 'abbreviations': [494], 'used': [495, 2511, 2641, 2741, 2867], 'are:': [496], 'SBD,': [497], 'domain;': [500, 528], 'DnaK1A,': [501, 1491, 1855, 3278, 3935, 4096, 4336], 'DnaK(D526A);': [502], 'DnaK2A,': [503, 1492, 3302, 3919], 'DnaK(D540A/K548A);': [504], 'DnaK3A,': [505, 3490, 3744, 4068, 4102], 'DnaK(E531A/R536A/R547A);': [506], 'DSC,': [507, 4436], 'differential': [508], 'scanning': [509, 2049, 2159, 2592], 'calorimetry;': [510], 'MS,': [511], 'mass': [512, 2561, 2570, 2613, 2670, 2682, 2836, 2840], 'spectrometry;': [513], 'MS/MS,': [514], 'tandem': [515], 'MS;': [516], 'MALDI,': [517], 'matrix-assisted': [518], 'laser': [519], 'desorption': [520], 'ionization;': [521, 524], 'ESI,': [522], 'electrospray': [523, 2669], 'NBD,': [525], 'nucleotide': [526], 'wt,': [529], 'wild': [530], 'type;': [531], 'F-APPY,': [532], 'fluorescein-CALLQSRLLLSAPRRAAATARY': [533], 'peptide;': [534], 'ACN,': [535, 2733], 'acetonitrile.': [536], 'SBD': [538, 851, 924, 1175, 1314, 1358, 1464, 3129], 'contains': [539, 4510], 'holds': [543, 3491], 'groove,': [547], 'α-helical': [550, 1036, 1454], 'folds': [553], 'over': [554, 929, 2798], 'β-structure': [556, 1032], 'might': [558, 1315, 3263, 3546], 'control': [559, 3342], 'accessibility': [560, 3344], 'High': [566], 'resolution': [567, 3955], 'three-dimensional': [568], 'structures': [569], 'isolated': [571], 'forms': [572], 'both': [574, 1357, 4516], 'domains': [576, 4545], 'with': [577, 958, 1125, 1180, 1352, 1758, 1886, 1964, 2149, 2210, 2291, 2361, 2373, 2468, 2528, 2543, 2706, 2754, 2790, 3605, 3715, 3830, 3951, 4065, 4147, 4346], 'different': [578, 1396, 1733, 2173, 2235, 3860, 4134], 'bound': [579, 890, 1028, 1198, 1777, 2533, 4144], 'ligands': [580], 'reported': [583, 3650, 4357], '(2Flaherty': [584], 'K.M.': [585, 1686], 'Peluca-Flaherty': [586], 'C.': [587, 1145, 1147, 1668, 3449, 3475, 3692], 'McKay': [588, 3442], 'D.B.': [589, 3443], 'Nature.': [590], '1990;': [591], '346:': [592], '623-628Crossref': [593], '(833)': [596], 'Scholar,': [598, 615, 638, 659, 682, 702, 728, 746, 765, 997, 1073, 1680, 1808, 1932, 3365, 3388, 3411, 3433, 3467, 3672, 3688, 4006], '3Morshauser': [599], 'R.C.': [600, 617], 'Wang': [601, 620, 3474], 'H.': [602, 621, 640, 1616, 1618], 'Flynn': [603, 624, 647], 'G.C.': [604, 625, 648], 'Zuiderwerg': [605, 649], 'E.R.': [606, 627, 650, 717, 750, 3439], 'Biochemistry.': [607, 651, 1078], '1995;': [608, 1632], '34:': [609, 2461], '6261-6266Crossref': [610], '(94)': [613], '4Morshauser': [616], 'Hu': [618, 645], 'W.': [619, 646, 2278], 'Pang': [622], 'Y.': [623, 644, 748, 806], 'Zuiderweg': [626, 716, 735, 749, 813, 1004], 'J.': [628, 693, 774, 815, 853, 1058, 1097, 1148, 1626, 1629, 1669, 1799, 1820, 1917, 1944, 2117, 2448, 2457, 2987, 3390, 3418, 3452, 3657, 3679, 3991, 4013, 4223, 4372, 4469], 'Biol.': [630, 720, 776, 817, 1059, 1098, 1149, 1222, 1291, 1630, 1670, 1801, 1918, 2119, 2988, 3419, 3453, 3658, 3681, 3992, 4014, 4224, 4373, 4471], '1999;': [631, 1802, 2460, 3682, 3702], '289:': [632], '1387-1403Crossref': [633], '(136)': [636], '5Wang': [639], 'Kurochkin': [641, 811], 'A.V.': [642], 'Pan': [643], '1998;': [652, 2990], '37:': [653], '7929-7940Crossref': [654], '(121)': [657], '6Zhu': [660, 3366], 'X.': [661, 663, 976, 978, 1362, 1364, 1468, 1470, 3194, 3196, 3367, 3369], 'Zhao': [662, 977, 1363, 1469, 3195, 3368], 'Burkholder': [664, 979, 1365, 1471, 3197, 3370], 'W.F.': [665, 980, 1366, 1472, 3198, 3371], 'Gragerov': [666, 981, 1367, 1473, 3199, 3372], 'A.': [667, 757, 982, 1096, 1368, 1474, 1510, 1581, 1614, 1816, 1818, 1940, 1942, 2272, 2274, 2276, 2904, 3200, 3373, 3417, 3656, 3701, 4012, 4222], 'Ogata': [668, 983, 1369, 1475, 3201, 3374], 'C.M.': [669, 984, 1370, 1476, 3202, 3375], 'Gottesman': [670, 985, 1371, 1477, 3203, 3376], 'M.E.': [671, 986, 1372, 1478, 3204, 3377], 'Hendrickson': [672, 987, 1373, 1479, 3205, 3378], 'W.A.': [673, 988, 1374, 1480, 3206, 3379], 'Science.': [674, 694, 989, 1375, 1481, 3207, 3380], '1996;': [675, 990, 1376, 1482, 2283, 3208, 3381], '272:': [676, 991, 1377, 1483, 1822, 1946, 3209, 3382, 3456], '1606-1614Crossref': [677, 992, 1378, 1484, 3210, 3383], '(1064)': [680, 995, 1381, 1487, 3213, 3386], '7Harrison': [683], 'C.J.': [684], 'Hayer-Hartl': [685], 'M.': [686, 689, 704, 734, 804, 1003, 1143, 1659], 'Di': [687], 'Liberto': [688], 'Hartl': [690], 'F.': [691, 1092, 1506, 1577, 1810, 1934, 2900, 3413, 3652, 4008, 4218], 'Kuriyan': [692], '1997;': [695, 3455], '276:': [696, 1062, 1921, 3995], '431-435Crossref': [697], '(413)': [700], '8Pellecchia': [703], 'Montgomery': [705], 'D.L.': [706, 1794, 3674], 'Stevens': [707], 'S.Y.': [708, 730, 999], 'Vander': [709], 'Kooi': [710], 'C.W.': [711], 'Feng': [712], 'H.P.': [713], 'Gierasch': [714, 1797, 3677], 'L.M.': [715, 1798, 3678], 'Nat.': [718, 1220, 1289], 'Struct.': [719, 1221, 1290], '2000;': [721, 1223, 1292], '7:': [722, 1224, 1293], '298-303Crossref': [723], '(182)': [726], '9Stevens': [729, 998], 'Caif': [731, 1000], 'S.': [732, 756, 1001, 1666, 3447, 3700], 'Pellecchia': [733, 1002], 'E.R.P.': [736, 814, 1005], 'Protein': [737, 1006, 1692, 2065, 2152, 2618, 2915, 4430], '2003;': [739, 1008, 1513, 1584, 2907], '12:': [740, 1009], '2588-2596Crossref': [741, 1010], '(92)': [744, 1013], '10Zhang': [747], 'Proc.': [751, 3695], 'Natl.': [752, 3696], 'Acad.': [753, 3697], 'U.': [755, 3437, 3699], '2004;': [758, 777, 1100, 3421, 3660, 4016, 4226], '101:': [759], '10272-10277Crossref': [760], '(74)': [763], '11Cupp-Vickery': [766], 'J.R.': [767], 'Peterson': [768], 'J.C.': [769], 'Ta': [770], 'D.T.': [771], 'Vickery': [772], 'L.E.': [773], '342:': [778], '1265-1278Crossref': [779], '(88)': [782], 'Recently': [785], 'model': [787, 3733, 3835], 'two-domain': [790], 'truncated': [791], 'Thermus': [794], 'thermophilus': [795], 'has': [796, 1040, 1241], 'proposed': [798, 1243, 1460], 'based': [799], 'on': [800, 1753, 1958, 2171, 2565, 2788, 2853], 'NMR': [801], 'studies': [802], '(12Revington': [803], 'Zhang': [805], 'Grovern': [807], 'N.B.': [808], 'Alexander': [809], 'Y.-V.': [810], '349:': [819], '163-183Crossref': [820], '(68)': [823], 'Some': [826], 'better': [832], 'revealed': [833], 'x-ray': [836], 'structure': [837, 1466, 4250, 4285], 'bovine': [840, 3054], 'Hsc70': [841], 'lacks': [843], 'helical': [847, 920, 968, 1349, 3150, 3154, 3187], '(13Jiang': [852], 'Prasad': [854, 3391], 'K.': [855, 1139, 1215, 1284, 3392], 'Lafer': [856, 3393], 'E.M.': [857, 3394], 'Sousa': [858, 3395, 3444], 'R.': [859, 2112, 2114, 2454, 3396, 4464, 4466], 'Cell.': [861, 3398], '20:': [863, 3400], '513-524Abstract': [864, 3401], 'Full': [865, 867, 1064, 1066, 1103, 1105, 1154, 1635, 1637, 1675, 1923, 1925, 2993, 2995, 3402, 3404, 3424, 3426, 3458, 3460, 3663, 3665, 3997, 3999, 4019, 4021, 4229, 4231, 4378], 'Text': [866, 868, 1065, 1067, 1104, 1106, 1155, 1636, 1638, 1676, 1924, 1926, 2994, 2996, 3403, 3405, 3425, 3427, 3459, 3461, 3664, 3666, 3998, 4000, 4020, 4022, 4230, 4232, 4379], 'PDF': [869, 1068, 1107, 1156, 1639, 1677, 1927, 2997, 3406, 3428, 3462, 3667, 4001, 4023, 4233, 4380], '(249)': [872, 3409], 'In': [875, 1192, 1384, 2945, 3272, 3633, 3931, 4138, 4384], 'DnaK,': [876, 1854, 3231, 3638, 3647, 3918, 4095, 4335], 'best': [878], 'bacterial': [880, 1567], 'representative': [881], 'family,': [885], 'is': [889, 1171, 1196, 1250, 1338, 2099, 3144, 3245, 3297, 3339, 3525, 3576, 3929, 3939, 3973, 4063, 4078, 4132, 4159, 4207, 4402, 4416, 4427, 4495], 'extended': [893], 'conformation': [894, 1179, 2098, 4426], 'protrude': [899], '(L1,2': [904], 'L3,4),': [906], 'turn': [910], 'buttressed': [911], 'by': [912, 1497, 1696, 2443, 2518, 2590, 2622, 3031, 3083, 3167, 3184, 3240, 3621, 3813, 4262, 4313, 4435], 'other': [914], '(L4,5': [916], 'L5,6).': [918], 'acts': [925, 971], 'like': [926], 'subdomain.': [932, 3556], 'α-helices': [934], 'A': [935, 2471, 2507, 2737, 4056, 4167], 'packed': [939, 2484], 'onto': [940, 2539, 2696], 'covers': [946], 'cavity.': [950], 'distal': [952], 'B,': [956, 1536], 'together': [957], 'helices': [959, 3512], 'C,': [960, 1541], 'D,': [961, 1544], 'E,': [963, 1549], 'builds': [964], 'up': [965], 'hydrophobic': [967, 1126], 'core': [969], '"lid"': [974], '(6Zhu': [975, 1361, 1467, 3193], 'Although': [1016, 3574, 3871], 'coupling': [1018], 'occurs': [1019], 'absence': [1022, 2217], 'subdomain,': [1037, 3260, 3541], 'its': [1038, 3159, 3175], 'presence': [1039, 2219, 2848, 3635], 'confirmed': [1042], 'be': [1044, 1316, 1342, 2084, 3969, 4082, 4407], 'stabilizing': [1047], 'Hsp70-substrate': [1048], '(14Buckzynski': [1050, 1909, 3983], 'G.': [1051, 1622, 1910, 3984], 'Slepenkov': [1052, 1911, 3985], 'V.': [1053, 1094, 1508, 1579, 1812, 1912, 1936, 2902, 3415, 3654, 3986, 4010, 4220], 'Shorn': [1054, 1913, 3987], 'M.G.': [1055, 1914, 3988], 'Witt': [1056, 1076, 1915, 3989], 'S.N.': [1057, 1077, 1916, 3990], 'Chem.': [1060, 1099, 1150, 1631, 1671, 1919, 2282, 2989, 3420, 3454, 3659, 3993, 4015, 4225, 4374], '2001;': [1061, 1688, 1920, 3479, 3994], '27231-27236Abstract': [1063, 1922, 3996], '(69)': [1071, 1930, 4004], '15Slepenkov': [1074], 'S.V.': [1075], '2002;': [1079, 2500], '41:': [1080], '12224-12235Crossref': [1081], '(49)': [1084], 'Scholar),': [1086], 'especially': [1087, 1343], 'temperatures': [1090, 4036, 4053, 4156], '(16Moro': [1091, 3651, 4217], 'Fernández-Sáiz': [1093, 3414, 3653, 4009, 4219], 'Muga': [1095, 1509, 1580, 1817, 1941, 2903, 3416, 3655, 4011, 4221], '279:': [1101, 3422, 3661, 4017, 4227], '19600-19606Abstract': [1102, 3423, 3662, 4018, 4228], '(39)': [1110, 3431, 3670, 4026, 4236], 'broad': [1114], 'spectrum': [1115], 'activities': [1117], 'exhibit': [1121], 'requires': [1122], 'their': [1123, 1246, 3925, 4423], 'interaction': [1124, 3534, 3549], 'segments': [1127, 3188], '(partially)': [1129], 'unfolded': [1130], 'polypeptide': [1131], 'chains,': [1132], 'nucleotide-controlled': [1135], 'unknown': [1136], 'mechanism': [1137], '(17Liberek': [1138], 'Skowyra': [1140], 'D.': [1141, 2110, 4462], 'Zylicz': [1142], 'Johnson': [1144], 'Georgopoulos': [1146], '1991;': [1151], '266:': [1152], '14491-14496Abstract': [1153], 'When': [1160, 2846, 4059], 'binds': [1162, 3646], 'Hsp70s,': [1167], 'signal': [1170], 'transmitted': [1172], 'adopts': [1177], 'fast': [1181, 3941], 'association': [1183, 3902], 'dissociation': [1185, 1278, 3755, 3905], 'rates': [1186], 'and,': [1187, 4292], 'therefore,': [1188, 4293], 'low': [1189], 'affinity.': [1191], 'contrast,': [1193, 4385], 'tightly': [1197], 'ADP-bound': [1201], 'conformation,': [1202], 'displays': [1204, 4391], 'high': [1206, 2100, 4507], 'affinity': [1207, 1247, 3749, 3926, 4202], 'substrates': [1209, 3618], '(18Mayer': [1210, 1279], 'Laufen': [1212, 1281], 'T.': [1213, 1282, 1661], 'Paal': [1214, 1283], 'McCarty': [1216, 1285, 1619], 'J.S.': [1217, 1286, 1620], '586-593Crossref': [1225, 1294], '(311)': [1228, 1297], 'One': [1231], 'important': [1235, 3246], 'characteristics': [1236], 'conformations,': [1239], 'dictate': [1245], 'peptides,': [1249], 'SBD.': [1262], 'site': [1273, 3349, 3731, 3833], 'seems': [1274], 'facilitate': [1276], 'Therefore,': [1300], 'analysis': [1301, 2420, 2437], 'anchor': [1306], 'relevant': [1317], 'localize': [1319], 'regions': [1322], 'allow': [1327], 'movement.': [1329], 'Among': [1330], 'these': [1331, 3221, 3523, 3913], 'interactions,': [1332], 'those': [1333, 1458, 3543, 3595, 3882], 'seem': [1340], 'relevant,': [1344], 'because': [1345, 3261], 'residues': [1346, 1400, 3143, 3254, 3507, 3567], 'segment': [1350, 3151], 'interact': [1351], 'amino': [1353, 1405], 'acids': [1354, 1406], 'belonging': [1355], 'units': [1360, 2212], 'work,': [1386], 'systematically': [1388], 'compare': [1389], 'lack': [1395], 'β-subdomains,': [1411], 'respectively.': [1412, 2666, 2926], 'indicate': [1415, 3923], 'salt': [1418, 3280, 3310, 3500], 'bridge': [1419, 3281, 3311], 'Asp526-Arg445': [1420], 'plays': [1421], 'pivotal': [1423], 'role': [1424], 'properly': [1426], 'positioning': [1427], 'lid,': [1429], 'β-subdomain.': [1433, 3329], 'Data': [1434, 1878], 'presented': [1435], 'here': [1436, 4259], 'favor': [1437], 'open': [1443], 'closed': [1445], 'conformations': [1447], 'involves': [1449], 'changes': [1451, 4181], 'larger': [1456], 'than': [1457], 'initially': [1459], 'crystal': [1465], 'Mutants': [1490], 'DnaK3A': [1494, 1559, 3545, 3878, 3921, 4390], 'were': [1495, 1563, 1603, 1648, 1707, 1742, 1751, 1788, 1832, 1879, 1956, 1972, 1989, 2007, 2067, 2129, 2143, 2165, 2205, 2232, 2253, 2297, 2357, 2383, 2395, 2432, 2535, 2578, 2588, 2599, 2607, 2640, 2659, 2672, 2752, 2786, 2807, 2826, 2919, 2928, 2968, 3255, 3713, 3810, 3823, 3852, 4331], 'obtained': [1496, 2589, 3714, 3853, 4332], 'sequential': [1498], 'PCR': [1499, 1561], 'steps': [1500], 'using': [1501, 1842, 2031, 2145, 2438, 2583, 2631, 2674, 2814, 3107], 'flanking': [1503], 'primers': [1504, 1523], '(19Moro': [1505, 1576, 2899], 'Fernández': [1507, 1578, 2901], 'FEBS': [1511, 1582, 1819, 1943, 2905], 'Lett.': [1512, 1583, 2906], '533:': [1514, 1585, 2908], '119-123Crossref': [1515, 1586, 2909], '(72)': [1518, 1589, 2912], 'Scholar)': [1520, 1591, 2290, 2467], 'mutagenic': [1522], '(underlined': [1524], 'letters': [1525], 'nucleotides': [1528], 'changed': [1529], 'each': [1531, 1779, 2176, 2381, 3232, 3724], 'mutation):': [1532], 'A,': [1533, 3172], '5′-GVVGAAGCTGCCCGTAAGTTG-3′': [1534], '5′-CTTACGGGCAGCTTCGGCG-3′,': [1537], 'DnaK1A': [1539, 3529, 3742, 3895, 4136, 4204, 4535], '(D526A);': [1540], '5′-CGCCCATCTGCTGCACAGCACCCGTGCCAGGTTGAAG-3′': [1542], '5′-GCGCACGGGTGCTGTGCAGCAGATGGGCGCCCTGG-3′,': [1545], 'DnaK2A': [1547, 3531, 3884, 4066, 4338], '(D540A/K548A);': [1548], '5-GAAGCGCTGGTACAGACTGCCAACCAGGCG-3′;': [1550], 'F,': [1551], '5′-GTTGGCAGTCTGTACCAGCGCTTCAAAC-3′;': [1552], 'G,': [1553], '5′-CACAGCACCGCTAAGCAGGTTGAAGAAG-3′': [1554], 'H,': [1556], '5′-CTGCTTAGCGGTGCTGTGCAG-3′': [1557], '(E531A/R536A/R547A).': [1560], 'products': [1562], 'cloned': [1564], 'expression': [1568], 'vector': [1569], 'pTrc99A': [1570], '(Amersham': [1571], 'Biosciences)': [1572], 'described': [1574, 1656, 1791, 1908, 2442, 2897, 2978, 4210], 'previously': [1575, 1792, 2898, 2977, 3649, 4356, 4459], 'sequenced': [1593], 'verify': [1595], 'encoded': [1597], 'proteins.': [1598], 'expressed,': [1604], 'purified,': [1605], 'extensively': [1607, 2068], 'dialyzed': [1608, 2069], 'obtain': [1610, 1900, 3943], 'nucleotide-free': [1611], 'samples': [1612, 2066], '(20Buchberger': [1613], 'Theyssen': [1615], 'Schröder': [1617], 'Virgallita': [1621], 'Milkereit': [1623], 'P.': [1624, 2456, 2498, 2986], 'Reinstein': [1625], '270:': [1633], '16903-16910Abstract': [1634], '(224)': [1642], 'DnaJ': [1645, 2965], 'GrpE': [1647, 2967], 'expressed': [1649], 'BL21': [1651], 'cells': [1652], 'purified': [1654, 2433], 'elsewhere': [1657], '(21Zylicz': [1658], 'Yamamoto': [1660], 'Mc': [1662], 'Kittrick': [1663], 'N.': [1664], 'Sell': [1665], 'Geosgopoulos': [1667], '1985;': [1672], '260:': [1673], '7591-7598Abstract': [1674], '22Mehl': [1681], 'A.F.': [1682], 'Heskett': [1683], 'L.D.': [1684], 'Neal': [1685], 'BBA.': [1687], '282:': [1689], '562-569Google': [1690], 'concentration': [1693, 1782, 1898, 2153, 2918, 2960, 4088], 'was': [1694, 1783, 1894, 2029, 2039, 2056, 2154, 2161, 2185, 2328, 2339, 2353, 2483, 2510, 2524, 2563, 2620, 2649, 2694, 2721, 2740, 2777, 2856, 2866, 2877, 2955, 3007, 3029, 3081, 3091, 3238, 3619, 3726, 4089, 4120, 4260, 4311, 4321, 4432], 'determined': [1695], 'colorimetric': [1698], 'Bradford': [1699], 'assay': [1700, 3110], '(Bio-Rad).': [1701], 'F-APPY': [1702, 1731, 1843, 3751, 3815, 3928, 4164, 4206], '(fluorescein-CALLQSRLLLSAPRRAAATARY)': [1704], 'experiments': [1706], 'performed': [1708, 1990, 2057, 2564, 2621, 2787, 4064], '25': [1710, 1835, 2071, 2362, 2832, 3013, 3035, 3100, 4174], 'mm': [1711, 1716, 1719, 1722, 1868, 1996, 2072, 2190, 2194, 2197, 2222, 2305, 2337, 2363, 2881, 2886, 2889, 3021, 3026, 3039, 3044, 3047, 3050, 3062, 3087], 'Hepes,': [1712, 2882], 'pH': [1713, 2074, 2090, 2883, 3023, 3041], '7.6,': [1714], '50': [1715, 1740, 1979, 2193, 2304, 2336, 2885, 3038], 'KCl,': [1717, 2195, 2887, 3045], '5': [1718, 2201, 2228, 2424, 2711, 3086], 'MgCl2,': [1720, 3048], '1': [1721, 1737, 1851, 1976, 2221, 2843, 2924], 'dithiothreitol.': [1723, 3027], 'ensure': [1725], 'equilibrium,': [1726], 'mixtures': [1727], 'containing': [1728, 2227, 2303, 3057], '35': [1729, 1848], 'nm': [1730, 1738, 1849, 1977, 1980, 2028, 2936, 3036, 4320], 'concentrations': [1735, 1846], '(from': [1736], 'μm)': [1741], 'incubated': [1743, 2206], 'overnight': [1744], '4': [1746, 2797], '°C.': [1747], 'Fluorescence': [1748], 'anisotropy': [1749, 3626, 3640, 3721, 4046, 4077, 4184], 'recorded': [1752, 1957], 'SLM8100': [1755], 'spectrofluorometer': [1756], '(Aminco)': [1757], 'excitation': [1759], '492': [1761], 'nm,': [1762, 1766], 'emission': [1763], '516': [1765], 'slit': [1768], 'widths': [1769], '8': [1771], 'nm.': [1772], 'fraction': [1774], 'calculated,': [1784], 'fitted': [1789, 1880, 3727, 3824], '(23Montgomery': [1793], 'Morimoto': [1795, 3675], 'R.I.': [1796, 3676], '296:': [1803, 3683], '915-932Crossref': [1804, 3684], '(129)': [1806, 3686], '24Moro': [1809, 1933], 'Fernandez-Saiz': [1811, 1935], 'Slutsky': [1813, 1937], 'O.': [1814, 1938], 'Azem': [1815, 1939], '3184-3196Crossref': [1823, 1947], '(13)': [1826, 1950], 'Peptide': [1829, 3606], 'kinetics': [1831], 'analyzed': [1833, 2144, 2579, 3620, 3864, 4261], '°C,': [1836, 1838, 2895, 3014, 3101, 3103, 3106, 4354, 4396], '37': [1837, 2349, 3102], '42': [1840, 3105, 4177], '°C': [1841, 1993, 2043, 2046, 2053, 2209, 2350, 4175, 4178, 4351, 4401, 4415], 'μm': [1852, 1860, 2202, 2921, 2974, 3071, 3074, 3078, 4092, 4100], '(wt': [1853], 'DnaK2A)': [1857], 'or': [1858, 2218, 2224, 2796, 3104], '3': [1859, 2920, 4099], '(DnaK3A)': [1861], 'Hsp70,': [1862, 3072], 'respectively,': [1863, 2975], 'well': [1865], '0.5': [1867, 2544, 3052], 'temperatures.': [1877], 'monoexponential': [1883], 'equation': [1884], 'consistent': [1885], 'bimolecular': [1888, 4033], 'reaction': [1889], 'kobs': [1892, 3843], 'value': [1893, 3641, 3947, 4047, 4412], 'plotted': [1895], 'against': [1896, 2070, 2809, 4128], 'parameters': [1903, 1971, 2639, 2825, 3806, 3857, 3915, 4441], 'k+1': [1904, 3807, 3850], 'k-1': [1906, 3809, 3847], 'Far-UV': [1953], 'CD': [1954, 4263], 'spectra': [1955, 2587, 2598, 2671, 2806], 'Jasco': [1960], 'J-810': [1961], 'spectropolarimeter': [1962], 'equipped': [1963], 'thermoelectric': [1966], 'cell': [1967], 'holder.': [1968], 'collection': [1970], '0.5-mm': [1973], 'path': [1974, 2034], 'length,': [1975], 'bandwidth,': [1978], 'min-1': [1981], 'scan': [1982], 'rate,': [1983], '0.5-s': [1985], 'response': [1986], 'time.': [1987], 'Scans': [1988], '20': [1992, 2042, 2333, 2718, 3065], '10': [1995, 2010, 2196, 2398, 2411, 3025], 'sodium': [1997], 'borate': [1998], '(pH': [1999, 2199], '9.0)': [2000], '0.3': [2002, 2962, 2971], 'mg·ml-1': [2003, 2156, 3053], 'concentration.': [2005, 2016], 'Spectra': [2006, 2606], 'averaged': [2008, 2600], 'scans': [2011], 'normalized': [2013], 'For': [2017, 2820], 'thermal': [2019, 4130, 4306], 'stability': [2020, 4123, 4307, 4431], 'experiments,': [2021], 'mean': [2023], 'residue': [2024, 3234], 'ellipticity': [2025, 4276, 4317, 4411], '222': [2027, 4319], 'monitored': [2030], '2-mm': [2033], 'length': [2035], 'cell,': [2036], 'temperature': [2038, 4072, 4148, 4482, 4508], 'increased': [2040], '90': [2045, 4414], 'rate': [2050, 2160, 2716, 2746, 4039], '60': [2052, 2162], 'h-1.': [2054], 'DSC': [2055, 4520], 'VP-DSC': [2060], 'microcalorimeter': [2061], '(MicroCal,': [2062], 'Northampton,': [2063], 'MA).': [2064, 2773], 'glycine,': [2073], '9.0,': [2075], 'centrifuged': [2076], 'remove': [2078], 'aggregates,': [2079], 'degassed': [2081], 'prior': [2082, 2434], 'loaded': [2085, 2695], 'calorimeter.': [2088, 2151], 'At': [2089], '9.0': [2091], 'solubility': [2093], 'thermally': [2096, 4424], 'denatured': [2097, 3008, 4425], 'enough': [2101], 'make': [2103], 'denaturation': [2105, 4499, 4514], 'highly': [2107], 'reversible': [2108, 4180], '(25Montgomery': [2109, 4461], 'Jordan': [2111, 4463], 'McMacken': [2113, 4465], 'Freire': [2115, 4467], 'E.': [2116, 2450, 2452, 2982, 4468], '1993;': [2120, 4472], '232:': [2121, 4473], '680-692Crossref': [2122, 4474], '(61)': [2125, 4477], 'Experiments': [2128, 2164], 'carried': [2130, 2166, 2186], 'out': [2131, 2167, 2187], 'positive': [2133], 'pressure': [2134], 'avoid': [2136], 'degassing': [2137], 'during': [2138], 'heating.': [2139], 'calorimetric': [2141], 'ORIGIN': [2146], 'software': [2147], 'provided': [2148], '1-2': [2155], '°C·h-1.': [2163], 'least': [2169], 'twice': [2170], 'batches': [2174], 'Partial': [2178], 'proteolysis': [2179], '40': [2189, 2880], 'Hepes': [2191], 'buffer,': [2192], 'MgCl2': [2198], '7.6).': [2200], '30': [2208, 2324, 2894, 2938], '1.6': [2211], 'trypsin,': [2214, 2316], 'ADP.': [2225], 'Aliquots': [2226], 'μg': [2229], 'taken': [2233], 'incubation': [2236], 'times': [2237], 'diluted': [2239], 'directly': [2240, 2538, 2764], 'Laemmli': [2242], 'loading': [2243], 'buffer': [2244, 2302, 2892], '12.5%': [2246], 'SDS-PAGE': [2247], 'analysis.': [2248], 'In-gel': [2249], 'Digestion—Selected': [2250], 'tryptic': [2251, 2264], 'bands': [2252], 'cut': [2254], 'Coomassie': [2256], 'Blue-stained,': [2257], 'fixed': [2258, 2662], 'gels': [2259], 'subjected': [2261], 'in-gel': [2263], 'digestion': [2265, 2301, 2346], 'according': [2266], 'Shevchenko': [2268, 2275], 'et': [2269, 2445], 'al.': [2270, 2446], '(26Shevchenko': [2271], 'Loboda': [2273], 'Ens': [2277], 'Standing': [2279], 'K.G.': [2280], 'Anl.': [2281], '68:': [2284], '850-858Crossref': [2285], '(7831)': [2288], 'minor': [2292], 'modifications.': [2293, 2470], 'gel': [2295, 2343], 'pieces': [2296], 'swollen': [2298], 'NH4HCO3': [2306, 2338, 2364], '12.5': [2308], 'ng·μl-1': [2309], 'trypsin': [2310], '(Roche': [2311], 'Diagnostics,': [2312], 'recombinant,': [2313], 'proteomic': [2314], 'grade': [2315], 'Penzberg,': [2317], 'Germany)': [2318, 2406, 2492], 'ice': [2321], 'bath.': [2322], 'After': [2323], 'min': [2325, 2712, 2939, 3011], 'supernatant': [2327], 'removed': [2329], 'discarded,': [2331], 'μl': [2334, 2399, 2412, 2545, 2691], 'added': [2340, 2956, 2969, 4117], 'piece,': [2344], 'proceeding': [2347], 'overnight.': [2351], 'Supernatant': [2352], 'recovered,': [2354], 'peptides': [2356, 2431, 2534, 2751], 'extracted': [2358], 'twice:': [2359], 'first': [2360, 3274], 'acetonitrile': [2366], '(ACN)': [2367], '(Romil,': [2368], 'Cambridge,': [2369], 'UK)': [2370], 'second': [2372, 3180, 3300, 4493], '0.1%': [2374, 2401, 2414, 2529, 2707, 2734], 'trifluoroacetic': [2375, 2402, 2530], 'acid': [2376, 2403, 2416, 2551, 2709], 'ACN.': [2378], 'Supernatants': [2379], 'sample': [2382, 2594, 2693, 2855, 4172], 'pooled': [2384], 'dried': [2386], 'SpeedVac.': [2389], 'Prior': [2390], 'MS': [2392], 'analysis,': [2393], 'pellets': [2394], 'resuspended': [2396], '(Merck,': [2404], 'Darmstadt,': [2405], 'MALDI-MS': [2408, 2429, 2559], 'formic': [2415, 2708, 2735], '(Merck)': [2417], 'ESI-MS': [2419, 2667], 'sonicated': [2422], 'min.': [2425], 'Sample': [2426], 'Preparation': [2427], 'Analysis—Recovered': [2430], 'MALDI': [2436, 2541], 'customized': [2439], 'nano-columns': [2440], 'Gobom': [2444], '(27Gobom': [2447], 'Nordhoff': [2449], 'Mirgorodoskaya': [2451], 'Ekman': [2453], 'Roepstorff': [2455, 2497], 'Mass.': [2458], 'Spect.': [2459], '105-116Crossref': [2462], '(631)': [2465], 'some': [2469], 'column': [2472, 2517, 2523, 2728], 'consisting': [2473], '100-300': [2475], 'nl': [2476], 'activated': [2478], 'charcoal': [2479], 'Sigma': [2481], '(C-5510)': [2482], 'constricted': [2487], 'GELoader': [2488], 'tip': [2489, 2769], '(Eppendorf,': [2490], 'Hamburg,': [2491], '(28Larsen': [2493], 'M.R.': [2494], 'Cordwell': [2495], 'S.J.': [2496], 'Proteomics.': [2499], '9:': [2501], '1277-1287Crossref': [2502], '(119)': [2504], '1-ml': [2508], 'syringe': [2509], 'force': [2513], 'liquid': [2514], 'through': [2515, 3174], 'applying': [2519], 'air': [2520], 'pressure.': [2521], 'equilibrated': [2525, 2730], 'washed': [2527, 2705], 'acid,': [2531, 2556], 'subsequently': [2536], 'eluted': [2537, 2753], 'target': [2542], 'solution': [2548], 'α-cyano-4-hydroxycinnamic': [2550], '(20': [2552], 'μg·μl-1': [2553], 'ACN:trifluoroacetic': [2555], '70:30,': [2557], 'v/v).': [2558], 'Analysis—Peptide': [2560], 'fingerprinting': [2562], 'Bruker': [2567], 'Ultraflex': [2568], 'TOF/TOF': [2569], 'spectrometer': [2571, 2683], '(Bruker-Daltonics,': [2572], 'Bremen,': [2573], 'Germany).': [2574], 'Positively': [2575], 'ions': [2577], 'reflector': [2581], 'mode,': [2582], 'delayed': [2584], 'extraction.': [2585], 'randomly': [2591], 'surface.': [2595], 'Typically': [2596], '200-300': [2597], 'improve': [2602], 'signal-to-noise': [2604], 'ratio.': [2605], 'externally': [2608], 'calibrated': [2609], 'resulting': [2610], 'accuracy': [2614], '<70': [2616], 'ppm.': [2617], 'identification': [2619, 2822], 'searching': [2623, 2634], 'non-redundant': [2626], 'base': [2629, 2644, 2813], '(NCBI)': [2630], 'Mascot': [2633], 'engine': [2635], '(www.matrixscience.com).': [2636], 'following': [2638, 2824, 3814], 'searches:': [2645], 'one': [2646, 3139, 4509], 'missed': [2647, 2844], 'cleavage': [2648], 'allowed,': [2650], 'carbamidomethylation': [2652, 2829], 'cysteine': [2654], 'oxidation': [2656], 'methionine': [2658], 'selected': [2660], 'modification,': [2665], 'Analysis—Tandem': [2668], 'acquired': [2673], 'Micro': [2676], 'Q-TOF': [2677], '(Waters': [2678], 'Corp.,': [2679], 'Milford,': [2680], 'MA)': [2681], 'interfaced': [2684], 'CapLC': [2687], 'capillary': [2688, 2768, 2775], 'chromatograph.': [2689], '7': [2690], 'Symmetry300': [2698], 'C18': [2699], 'NanoEase': [2700, 2727], 'Trap': [2701], 'precolumn': [2702], '(Waters)': [2703, 2729], 'flow': [2715, 2738, 2745], 'μl·min-1.': [2719], 'Precolumn': [2720], 'connected': [2722], 'Atlantis': [2725], 'dC18': [2726], '5%': [2732], 'acid.': [2736], 'splitter': [2739], 'decrease': [2743], '200': [2748], 'nl·min-1,': [2749], '30-min': [2756], 'linear': [2757, 3840], 'gradient': [2758], '10%': [2760], '60%': [2762], 'ACN': [2763], 'nano-electrospray': [2767], '(New': [2770], 'Objective,': [2771], 'Woburn,': [2772], 'voltage': [2776], 'set': [2778], '1750': [2780], 'V,': [2781], 'data-dependent': [2783], 'MS/MS': [2784, 2870], 'acquisitions': [2785], 'precursors': [2789], 'charge': [2791], 'states': [2792], '2,': [2794], '3,': [2795], 'survey': [2800], 'm/z': [2801, 2862], 'range': [2802], '400-1500.': [2804], 'Obtained': [2805], 'searched': [2808], 'Swiss-Prot': [2811], 'ProteinLynx': [2815], 'Global': [2816], 'Server': [2817], '2.1': [2818], '(Waters).': [2819], 'adopted:': [2827], 'complete': [2828], 'cysteines;': [2831], 'ppm': [2833], 'tolerance;': [2837, 2841], '0.05-Da': [2838], 'fragment': [2839], 'cleavage.': [2845], 'particular': [2851], 'checked,': [2857], 'inclusion': [2859], 'list': [2860], 'precursor': [2865], 'acquisition.': [2871], 'Activity—Steady': [2873], 'activity': [2876, 3090], 'assayed': [2878], '7.5,': [2884], '11': [2888], 'magnesium': [2890], 'acetate': [2891], 'mm,': [2925, 2963], 'Reactions': [2927], 'followed': [2929], 'measuring': [2930, 3622], 'absorbance': [2932], 'decay': [2933], '340': [2935], 'Cary': [2942], 'spectrophotometer': [2943], '(Varian).': [2944], 'co-chaperone': [2949], 'stimulation': [2950], 'assays,': [2951], 'NRLLLTG': [2952], '(NR)': [2953], 'final': [2959, 4045, 4086], '0.9': [2973], '(29Pierpaoli': [2979], 'E.V.': [2980], 'Sandmeier': [2981], 'Schonfeld': [2983], 'H.J.': [2984], 'Christen': [2985], '273:': [2991], '6643-6649Abstract': [2992], '(75)': [3000], 'Refolding': [3003, 3028], 'Denatured': [3005], 'Luciferase—Luciferase': [3006], '45': [3010], '6': [3016, 3070, 3073], 'm': [3017], 'guanidine': [3018], 'HCl,': [3019], '100': [3020], 'Tris,': [3022, 3040], '7.7,': [3024, 3042], 'achieved': [3030], 'diluting': [3032], 'luciferase': [3033, 3109], '55': [3043], '15': [3046], '5.5': [3049], 'dithiothreitol,': [3051], 'serum': [3055], 'albumin,': [3056], 'ATP-regenerating': [3059], 'system': [3060, 3111], '(4': [3061], 'phosphoenolpyruvate': [3063], 'ng·ml-1': [3066], 'pyruvate': [3067], 'kinase)': [3068], 'DnaJ,': [3075], '7.2': [3077], 'GrpE.': [3079], 'Reactivation': [3080], 'initiated': [3082], 'addition': [3084], 'ATP.': [3088], 'Luciferase': [3089], 'measured': [3092, 4322], 'after': [3093], '90-min': [3095], 'reactivation': [3096], 'period': [3097], '(Promega': [3112], 'E1500)': [3113], 'Sinergy': [3116], 'HT': [3117], '(Biotek)': [3118], 'luminometer.': [3119], 'Design': [3120], 'Mutants—Analysis': [3122], 'reveals': [3130, 3562], 'six': [3133], 'found,': [3138], 'located': [3145, 3256], 'communicates': [3152], 'β-subdomains': [3156], 'participating,': [3157], 'via': [3158], 'region,': [3161, 3177], 'unit': [3165, 3182], 'formed': [3166, 3183], 'remaining': [3186], 'analyze': [3217, 4303], 'effect': [3219], 'functional': [3228], 'properties': [3229, 3268], 'corresponding': [3233], 'substituted': [3239], 'alanine': [3241], '(Fig.': [3242, 3572, 3734, 3836, 3854, 4054, 4165, 4189, 4340, 4451], '1A).': [3243], 'It': [3244, 4080, 4405], 'note': [3248], 'none': [3250], 'mutated': [3253, 3568], 'modify': [3264, 3532], 'substrate-binding': [3267], 'mutant,': [3275, 3301, 3489], 'DnaK(D526A),': [3276], 'named': [3277], 'half': [3285], 'bears': [3303], 'mutations': [3305, 3527, 4295], '(D540A/K548A)': [3306], 'break': [3308], 'hydrogen': [3314, 3504], 'bond': [3315, 3505], 'so-called': [3336], '"latch,"': [3337], 'believed': [3340], '13Jiang': [3389], '16Moro': [3412, 4007], '30Ha': [3434], 'J.-H.': [3435], 'Hellman': [3436], 'Jonson': [3438], 'Li': [3440], 'L.': [3441, 4365, 4367], 'M.C.': [3445], 'Takeda': [3446], 'Wernstedt': [3448], 'Wilbanks': [3450], 'S.M.': [3451], '27796-27803Abstract': [3457], '(29)': [3465], '31Chang': [3468], 'T.-C.': [3469], 'Hsiao': [3470], 'C.-D.': [3471], 'Wu': [3472], 'S.-J.': [3473], 'Arch.': [3476], 'Biochem.': [3477], 'Biophys.': [3478], '386:': [3480], '30-36Crossref': [3481], '(14)': [3484], 'third': [3488], 'substitutions': [3493], '(E531A/R536A/R547A)': [3494], 'hamper': [3496], 'formation': [3497], 'bridges': [3501], 'C': [3513], 'D': [3515], 'lid.': [3518], 'main': [3520], 'difference': [3521], 'whereas': [3542, 4397], 'alter': [3547, 4298], 'Multiple': [3557], 'alignment': [3558], 'sequences': [3561], 'conservation': [3564, 3602], 'degree': [3565], 'study': [3571], '1B).': [3573], 'Asp526/Arg445': [3575], 'widely': [3577], 'among': [3579], 'family': [3582], 'members,': [3583], 'latch': [3589], 'conserved,': [3593], 'lowest': [3601, 4481], 'degree.': [3603], 'Interaction': [3604], 'Substrates—The': [3607], 'ability': [3608], 'wt': [3610, 3637, 3876, 3917, 4094, 4244, 4252, 4290, 4334, 4449, 4530], 'bind': [3616, 4163], 'change': [3624, 4200], 'fluorescence': [3629], 'labeled': [3630], '(F-APPY).': [3632], 'increases': [3642], '23Montgomery': [3673], '32Davis': [3689], 'J.E.': [3690], 'Voisine': [3691], 'Craig': [3693], 'E.A.': [3694], '96:': [3703], '9269-9276Crossref': [3704], '(67)': [3707], 'Equilibrium': [3710], 'curves': [3712, 4330], 'increasing': [3716, 3818, 4035], 'concentrations,': [3718], 'increase': [3722, 3899], 'single': [3730, 3827, 3832, 3892], '2': [3735], 'Table': [3737, 3869], '1).': [3738], 'mutants,': [3740], 'particularly': [3741], 'slightly': [3747, 4049], 'decreased': [3748], '(Table': [3752], '1).TABLE': [3753], '1F-APPY': [3754], 'constantsKdk+1k−1μmm−1': [3758], '·s−1s−1·103DnaK0.11': [3759], '(±0.009)5700.60DnaK1A0.25': [3760], '(±0.019)91,400aThese': [3761], 'values': [3762, 3773, 3787, 3910, 4277], 'rough': [3765, 3776, 3790, 3962], 'estimation': [3766, 3777, 3791, 3963], 'kinetic': [3769, 3780, 3794, 3805, 3873, 3914, 3949, 3966], 'constants': [3770, 3781, 3795, 3874, 3967], '(see': [3771, 3782, 3796, 3956], 'text).16.45aThese': [3772], 'text).DnaK2A0.18': [3783], '(±0.013)13760.81DnaK3A0.41': [3784], '(±0.007)6140.50a': [3785], 'text).': [3797], 'Open': [3798], 'table': [3799], 'new': [3802], 'tab': [3803], 'estimated': [3812, 3911], 'concentrations.': [3820], 'exponential': [3828], 'compatible': [3829], '3A).': [3837], 'From': [3838], 'plots': [3841], 'versus': [3844], 'concentration,': [3846], '(y-intercept)': [3848], '(slope)': [3851], '3B).': [3855], 'clearly': [3859, 4133], 'here,': [3865], 'seen': [3867], '1.': [3870], 'very': [3880], 'similar,': [3881], '1.4-': [3886], '2-times': [3888], 'higher,': [3889], 'mutation': [3893], 'induces': [3896, 4179], 'dramatic': [3898], '(∼160-fold)': [3903], '(∼27.4-fold)': [3906], 'rates.': [3907], 'Kd': [3909, 3946], 'comparable.': [3930], 'case': [3933], 'process': [3938], 'too': [3940], 'reliable': [3945], 'measurements': [3950], 'our': [3952], 'experimental': [3953], 'time': [3954], 'Fig.': [3957, 4103, 4268], '3A),': [3958], 'only': [3960], 'achieved.': [3970], 'behavior': [3972], 'similar': [3974, 4286, 4347, 4417], 'observed': [3977], 'lidless': [3981, 4213], 'mutant': [3982, 4158, 4214, 4280], 'As': [4029, 4265], 'expected': [4030], 'reaction,': [4034], 'enhance': [4037], 'DnaK-peptide': [4041], 'formation,': [4043], 'being': [4048], 'lower': [4050], 'higher': [4052], '4,': [4055, 4166], 'B).': [4058, 4169], 'experiment': [4062], 'essentially': [4069], 'dependence': [4073], 'observed.': [4079], 'should': [4081, 4406], 'noted': [4083, 4408], 'adjusted': [4090], '(1': [4091], 'DnaK2A;': [4098], '2A)': [4104], 'account': [4106], 'differences': [4109], 'affinity,': [4111], 'so': [4112], '>90%': [4114], 'bound.': [4121], 'substrate-protein': [4126], 'challenge': [4131], 'mutant.': [4137], 'case,': [4140], 'amount': [4142], 'diminishes': [4146], 'way': [4152], 'unable': [4160], 'stably': [4162], 'Cycling': [4170], 'DnaK1A-peptide': [4187], 'mixture': [4188], '4C),': [4190], 'indicating': [4191, 4421], 'temperature-induced': [4194], 'responsible': [4197], 'reversible,': [4208], 'Secondary': [4239], 'Structure': [4240], 'Stability': [4242], 'Mutants—The': [4248], 'secondary': [4249, 4284], 'studied': [4258], 'spectroscopy.': [4264], 'shown': [4266], '5A,': [4269], 'comparison': [4271], 'shapes': [4274], 'suggests': [4278], 'adopt': [4282], 'do': [4296, 4343], 'level.': [4301], 'whether': [4304], 'modified': [4312], 'mutations,': [4315], 'function': [4325], 'temperature.': [4327], 'Similar': [4328], 'melting': [4329, 4387], '5B).': [4341], 'display': [4344], 'transitions': [4345, 4455], 'amplitudes': [4348], '∼43': [4350], '70': [4353], '(33Palleros': [4362], 'R.D.': [4363], 'Shi': [4364], 'Reid': [4366], 'Katherine': [4368], 'Fink': [4370], 'L.A.': [4371], '1994;': [4375], '269:': [4376], '13107-13144Abstract': [4377], 'curve': [4388], '∼45': [4395], '∼70': [4400], 'hardly': [4403], 'detected.': [4404], 'all': [4419, 4523], 'similar.': [4429], 'provides': [4438], 'thermodynamic': [4440], 'unfolding': [4444, 4487], 'process.': [4445], 'thermogram': [4447, 4533], '6)': [4452], 'shows': [4453], 'assigned': [4460], 'comes': [4484], 'peak': [4494], 'due': [4496], 'contributions': [4511], 'domains.': [4518], 'profiles': [4521], 'differ': [4525], 'considerably': [4526], 'DnaK.': [4531], 'reflects': [4536], 'destabilization': [4538], 'ev': [4546]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2093983285', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 3}, {'year': 2016, 'cited_by_count': 4}, {'year': 2015, 'cited_by_count': 3}, {'year': 2013, 'cited_by_count': 4}, {'year': 2012, 'cited_by_count': 6}], 'updated_date': 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