Title: Calcium ionophore-stimulated chemiluminescence (CL) from human granulocytes: Evidence that A23187-induced chemiluminescence originates from arachidonic acid metabolism
Abstract: Abstract A23187 (calcium ionophore)-induced-granulocyte chemiluminescence is 1. (1) dependent on calmodulin (calcium binding protein) but independent of the oxidative burst, 2. (2) mainly due to arachidonate release from cellular phospholipids and subsequent metabolism, 3. (3) is not caused by the oxidative burst that accompanies various receptor stimulants. Sequential addition of A23187 followed by FMLP produces two different depolarizations of the membrane and two sequential peaks of chemiluminescence. It may be suggested that the origin of A23187 CL is mainly arachidonate metabolism while FMLP CL has at least two origins; oxidative burst and arachidonate metabolism.
Publication Year: 1983
Publication Date: 1983-12-01
Language: en
Type: article
Indexed In: ['crossref']
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Cited By Count: 4
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