Publication Information

{'id': 'https://openalex.org/W2093593565', 'doi': 'https://doi.org/10.1111/j.1750-3639.1993.tb00724.x', 'title': 'The Molecular and Cellular Biology of <i>Tau</i>', 'display_name': 'The Molecular and Cellular Biology of <i>Tau</i>', 'publication_year': 1993, 'publication_date': '1993-01-01', 'ids': {'openalex': 'https://openalex.org/W2093593565', 'doi': 'https://doi.org/10.1111/j.1750-3639.1993.tb00724.x', 'mag': '2093593565', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/8269082'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1111/j.1750-3639.1993.tb00724.x', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1750-3639.1993.tb00724.x', 'source': {'id': 'https://openalex.org/S9094144', 'display_name': 'Brain Pathology', 'issn_l': '1015-6305', 'issn': ['1015-6305', '1750-3639'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1750-3639.1993.tb00724.x', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5109111022', 'display_name': 'Kenneth S. Kosik', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1283280774', 'display_name': "Brigham and Women's Hospital", 'ror': 'https://ror.org/04b6nzv94', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1283280774', 'https://openalex.org/I48633490']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Kenneth S. Kosik', 'raw_affiliation_strings': ['Harvard Medical School Brigham and Women’s Hospital Boston, MA 02115'], 'affiliations': [{'raw_affiliation_string': 'Harvard Medical School Brigham and Women’s Hospital Boston, MA 02115', 'institution_ids': ['https://openalex.org/I1283280774']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5109111022'], 'corresponding_institution_ids': ['https://openalex.org/I1283280774'], 'apc_list': {'value': 3500, 'currency': 'USD', 'value_usd': 3500, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 1.692, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 109, 'citation_normalized_percentile': {'value': 0.997633, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 96, 'max': 97}, 'biblio': {'volume': '3', 'issue': '1', 'first_page': '39', 'last_page': '43'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10086', 'display_name': "Alzheimer's disease research and treatments", 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10086', 'display_name': "Alzheimer's disease research and treatments", 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10492', 'display_name': 'Microtubule and mitosis dynamics', 'score': 0.991, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10044', 'display_name': 'Protein Structure and Dynamics', 'score': 0.9907, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/tau-protein', 'display_name': 'Tau protein', 'score': 0.6969869}, {'id': 'https://openalex.org/keywords/microtubule-associated-protein', 'display_name': 'Microtubule-associated protein', 'score': 0.6652364}, {'id': 'https://openalex.org/keywords/neurite', 'display_name': 'Neurite', 'score': 0.58519536}, {'id': 'https://openalex.org/keywords/neurofilament', 'display_name': 'Neurofilament', 'score': 0.49011883}, {'id': 'https://openalex.org/keywords/tau-pathology', 'display_name': 'Tau Pathology', 'score': 0.44366258}, {'id': 'https://openalex.org/keywords/tangle', 'display_name': 'Tangle', 'score': 0.42427176}], 'concepts': [{'id': 'https://openalex.org/C20418707', 'wikidata': 'https://www.wikidata.org/wiki/Q189933', 'display_name': 'Microtubule', 'level': 2, 'score': 0.7902546}, {'id': 'https://openalex.org/C2778670691', 'wikidata': 'https://www.wikidata.org/wiki/Q419507', 'display_name': 'Tau protein', 'level': 4, 'score': 0.6969869}, {'id': 'https://openalex.org/C61081601', 'wikidata': 'https://www.wikidata.org/wiki/Q1102066', 'display_name': 'Microtubule-associated protein', 'level': 3, 'score': 0.6652364}, {'id': 'https://openalex.org/C142669718', 'wikidata': 'https://www.wikidata.org/wiki/Q154626', 'display_name': 'Cytoskeleton', 'level': 3, 'score': 0.6331826}, {'id': 'https://openalex.org/C113246987', 'wikidata': 'https://www.wikidata.org/wiki/Q1534415', 'display_name': 'Neurite', 'level': 3, 'score': 0.58519536}, {'id': 'https://openalex.org/C2779530196', 'wikidata': 'https://www.wikidata.org/wiki/Q178999', 'display_name': 'Axon', 'level': 2, 'score': 0.57364905}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.50636137}, {'id': 'https://openalex.org/C169760540', 'wikidata': 'https://www.wikidata.org/wiki/Q207011', 'display_name': 'Neuroscience', 'level': 1, 'score': 0.4978583}, {'id': 'https://openalex.org/C157207234', 'wikidata': 'https://www.wikidata.org/wiki/Q962115', 'display_name': 'Neurofilament', 'level': 3, 'score': 0.49011883}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.47180024}, {'id': 'https://openalex.org/C3017833866', 'wikidata': 'https://www.wikidata.org/wiki/Q2397106', 'display_name': 'Tau pathology', 'level': 4, 'score': 0.44366258}, {'id': 'https://openalex.org/C177738377', 'wikidata': 'https://www.wikidata.org/wiki/Q7683003', 'display_name': 'Tangle', 'level': 2, 'score': 0.42427176}, {'id': 'https://openalex.org/C12554922', 'wikidata': 'https://www.wikidata.org/wiki/Q7100', 'display_name': 'Biophysics', 'level': 1, 'score': 0.35451424}, {'id': 'https://openalex.org/C502032728', 'wikidata': 'https://www.wikidata.org/wiki/Q11081', 'display_name': "Alzheimer's disease", 'level': 3, 'score': 0.27554342}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.18770477}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.12660378}, {'id': 'https://openalex.org/C204232928', 'wikidata': 'https://www.wikidata.org/wiki/Q899285', 'display_name': 'Immunohistochemistry', 'level': 2, 'score': 0.122587204}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.1029371}, {'id': 'https://openalex.org/C1491633281', 'wikidata': 'https://www.wikidata.org/wiki/Q7868', 'display_name': 'Cell', 'level': 2, 'score': 0.09608436}, {'id': 'https://openalex.org/C33923547', 'wikidata': 'https://www.wikidata.org/wiki/Q395', 'display_name': 'Mathematics', 'level': 0, 'score': 0.0}, {'id': 'https://openalex.org/C2779134260', 'wikidata': 'https://www.wikidata.org/wiki/Q12136', 'display_name': 'Disease', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C202444582', 'wikidata': 'https://www.wikidata.org/wiki/Q837863', 'display_name': 'Pure mathematics', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C202751555', 'wikidata': 'https://www.wikidata.org/wiki/Q221681', 'display_name': 'In vitro', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D016875', 'descriptor_name': 'tau Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015394', 'descriptor_name': 'Molecular Structure', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009474', 'descriptor_name': 'Neurons', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D009474', 'descriptor_name': 'Neurons', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010766', 'descriptor_name': 'Phosphorylation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016875', 'descriptor_name': 'tau Proteins', 'qualifier_ui': 'Q000032', 'qualifier_name': 'analysis', 'is_major_topic': False}, {'descriptor_ui': 'D016875', 'descriptor_name': 'tau Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D016875', 'descriptor_name': 'tau Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D016875', 'descriptor_name': 'tau Proteins', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D016875', 'descriptor_name': 'tau Proteins', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1111/j.1750-3639.1993.tb00724.x', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1750-3639.1993.tb00724.x', 'source': {'id': 'https://openalex.org/S9094144', 'display_name': 'Brain Pathology', 'issn_l': '1015-6305', 'issn': ['1015-6305', '1750-3639'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/8269082', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1111/j.1750-3639.1993.tb00724.x', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1750-3639.1993.tb00724.x', 'source': {'id': 'https://openalex.org/S9094144', 'display_name': 'Brain Pathology', 'issn_l': '1015-6305', 'issn': ['1015-6305', '1750-3639'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 59, 'referenced_works': ['https://openalex.org/W1504754156', 'https://openalex.org/W150987474', 'https://openalex.org/W1554849694', 'https://openalex.org/W1562206355', 'https://openalex.org/W1570346440', 'https://openalex.org/W1590773131', 'https://openalex.org/W1598318710', 'https://openalex.org/W1611407165', 'https://openalex.org/W1663825042', 'https://openalex.org/W1779331731', 'https://openalex.org/W1863222819', 'https://openalex.org/W1903547297', 'https://openalex.org/W1944699774', 'https://openalex.org/W1968641736', 'https://openalex.org/W1971165215', 'https://openalex.org/W1971213386', 'https://openalex.org/W1971541898', 'https://openalex.org/W1972355725', 'https://openalex.org/W1980568542', 'https://openalex.org/W1994030229', 'https://openalex.org/W1995562130', 'https://openalex.org/W2000303735', 'https://openalex.org/W2005132906', 'https://openalex.org/W2007871841', 'https://openalex.org/W2008675281', 'https://openalex.org/W2013475161', 'https://openalex.org/W2018908557', 'https://openalex.org/W2019896687', 'https://openalex.org/W2020886328', 'https://openalex.org/W2026771024', 'https://openalex.org/W2028410287', 'https://openalex.org/W2032722811', 'https://openalex.org/W2035398662', 'https://openalex.org/W2035462700', 'https://openalex.org/W2036745486', 'https://openalex.org/W2038265658', 'https://openalex.org/W2038523706', 'https://openalex.org/W2051358675', 'https://openalex.org/W2055277461', 'https://openalex.org/W2057682957', 'https://openalex.org/W2059142088', 'https://openalex.org/W2060458492', 'https://openalex.org/W2068046501', 'https://openalex.org/W2078658743', 'https://openalex.org/W2089331767', 'https://openalex.org/W2090793855', 'https://openalex.org/W2102331922', 'https://openalex.org/W2114119114', 'https://openalex.org/W2116915509', 'https://openalex.org/W2123930515', 'https://openalex.org/W2124019813', 'https://openalex.org/W2124310598', 'https://openalex.org/W2127229268', 'https://openalex.org/W2128536686', 'https://openalex.org/W2135154440', 'https://openalex.org/W2165988981', 'https://openalex.org/W2170345361', 'https://openalex.org/W2295734120', 'https://openalex.org/W4241200637'], 'related_works': ['https://openalex.org/W4388364672', 'https://openalex.org/W4248325328', 'https://openalex.org/W4229033918', 'https://openalex.org/W2348030048', 'https://openalex.org/W2085728879', 'https://openalex.org/W2052787624', 'https://openalex.org/W2017132015', 'https://openalex.org/W1547872318', 'https://openalex.org/W1413100646', 'https://openalex.org/W126950150'], 'abstract_inverted_index': {'Tau': [0, 83], 'protein': [1, 18, 105], 'was': [2, 8, 84, 112], 'a': [3, 16, 32, 45, 89], 'well‐studied': [4], 'molecule': [5], 'before': [6], 'it': [7, 20, 111], 'discovered': [9], 'in': [10, 69], 'the': [11, 63, 120, 133], 'Alzheimer': [12, 76, 134], 'neurofibrillary': [13], 'tangles.': [14], 'As': [15], 'microtubule‐associated': [17], '(MAP),': [19], 'continues': [21], 'to': [22, 26, 75, 87], 'be': [23, 88], 'of': [24, 50, 54, 62, 67, 91], 'interest': [25], 'microtubule': [27], 'biologists': [28], 'who': [29], 'have': [30], 'provided': [31], 'rather': [33], 'rich': [34], 'knowledge': [35], 'about': [36], 'this': [37], 'protein.': [38], 'Recent': [39], 'work': [40], 'suggests': [41], 'that': [42, 114, 129], 'tau': [43, 68, 117], ',': [44], 'neuronal': [46], 'MAR': [47], 'is': [48], 'capable': [49], 'generating': [51], 'some': [52], 'features': [53], 'an': [55, 59], 'axonal': [56], 'shape': [57], 'and': [58, 80, 100], 'axon‐like': [60], 'organization': [61], 'cytoskeleton.': [64], 'The': [65], 'importance': [66], 'pathology': [70], 'stems': [71], 'from': [72, 119, 132], 'its': [73], 'relationship': [74], 'paired': [77, 92, 126], 'helical': [78, 93, 127], 'filaments': [79, 94, 128], 'dystrophic': [81], 'neurites.': [82], 'first': [85], 'believed': [86], 'component': [90], 'based': [95], 'upon': [96], 'immunocytochemical': [97], 'grounds': [98], '(1–6)': [99], 'then': [101], 'conclusively': [102], 'demonstrated': [103], 'by': [104], 'chemical': [106], 'techniques': [107], '(7–9).': [108], 'Most': [109], 'recently': [110], 'shown': [113], 'bacterially': [115], 'expressed': [116], 'fragments': [118], 'microtubule‐binding': [121], 'domain': [122], 'can': [123], 'self‐assemble': [124], 'into': [125], 'resemble': [130], 'those': [131], 'brain': [135], '(10).': [136]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2093593565', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 4}, {'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 5}, {'year': 2020, 'cited_by_count': 7}, {'year': 2019, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 6}, {'year': 2017, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 6}, {'year': 2015, 'cited_by_count': 3}, {'year': 2014, 'cited_by_count': 5}, {'year': 2013, 'cited_by_count': 5}, {'year': 2012, 'cited_by_count': 3}], 'updated_date': '2025-01-14T19:21:11.583206', 'created_date': '2016-06-24'}