Publication Information

{'id': 'https://openalex.org/W2093496165', 'doi': 'https://doi.org/10.1055/s-2008-1058089', 'title': 'Protein Kinase A Subunit Expression is Altered in Bloom Syndrome Fibroblasts and the BLM Protein is Increased in Adrenocortical Hyperplasias: Inverse Findings for <i>BLM</i> and <i>PRKAR1A</i>', 'display_name': 'Protein Kinase A Subunit Expression is Altered in Bloom Syndrome Fibroblasts and the BLM Protein is Increased in Adrenocortical Hyperplasias: Inverse Findings for <i>BLM</i> and <i>PRKAR1A</i>', 'publication_year': 2008, 'publication_date': '2008-06-01', 'ids': {'openalex': 'https://openalex.org/W2093496165', 'doi': 'https://doi.org/10.1055/s-2008-1058089', 'mag': '2093496165', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/18401830'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1055/s-2008-1058089', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S131832911', 'display_name': 'Hormone and Metabolic Research', 'issn_l': '0018-5043', 'issn': ['0018-5043', '1439-4286'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320000', 'host_organization_name': 'Thieme Medical Publishers (Germany)', 'host_organization_lineage': ['https://openalex.org/P4310320000'], 'host_organization_lineage_names': ['Thieme Medical Publishers (Germany)'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5090625410', 'display_name': 'Sarah L. Heyerdahl', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210144228', 'display_name': 'Eunice Kennedy Shriver National Institute of Child Health and Human Development', 'ror': 'https://ror.org/04byxyr05', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210144228']}, {'id': 'https://openalex.org/I1299303238', 'display_name': 'National Institutes of Health', 'ror': 'https://ror.org/01cwqze88', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'S L Heyerdahl', 'raw_affiliation_strings': ['Section on Endocrinology & Genetics, Program on Developmental Endocrinology and Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA.'], 'affiliations': [{'raw_affiliation_string': 'Section on Endocrinology & Genetics, Program on Developmental Endocrinology and Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA.', 'institution_ids': ['https://openalex.org/I4210144228', 'https://openalex.org/I1299303238']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5015077321', 'display_name': 'Sosipatros A. Boikos', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'S Boikos', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5030754052', 'display_name': 'Anélia Horvath', 'orcid': 'https://orcid.org/0000-0003-4117-013X'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'A Horvath', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5007547333', 'display_name': 'Christoforos Giatzakis', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'C Giatzakis', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5086246342', 'display_name': 'Ioannis Bossis', 'orcid': 'https://orcid.org/0000-0002-8501-7586'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'I Bossis', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5031897654', 'display_name': 'Constantine A. Stratakis', 'orcid': 'https://orcid.org/0000-0002-4058-5520'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'C A Stratakis', 'raw_affiliation_strings': [], 'affiliations': []}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.242, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 4, 'citation_normalized_percentile': {'value': 0.661935, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 76, 'max': 78}, 'biblio': {'volume': '40', 'issue': '6', 'first_page': '391', 'last_page': '397'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10631', 'display_name': 'Cancer, Hypoxia, and Metabolism', 'score': 0.9954, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10631', 'display_name': 'Cancer, Hypoxia, and Metabolism', 'score': 0.9954, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10301', 'display_name': 'Mitochondrial Function and Pathology', 'score': 0.9902, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11054', 'display_name': 'Adrenal and Paraganglionic Tumors', 'score': 0.9879, 'subfield': {'id': 'https://openalex.org/subfields/2746', 'display_name': 'Surgery'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/carney-complex', 'display_name': 'Carney Complex', 'score': 0.55371386}, {'id': 'https://openalex.org/keywords/bloom-syndrome', 'display_name': 'Bloom syndrome', 'score': 0.44191408}], 'concepts': [{'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.6203265}, {'id': 'https://openalex.org/C97029542', 'wikidata': 'https://www.wikidata.org/wiki/Q281417', 'display_name': 'Protein kinase A', 'level': 3, 'score': 0.59782964}, {'id': 'https://openalex.org/C2777108446', 'wikidata': 'https://www.wikidata.org/wiki/Q1044007', 'display_name': 'Carney complex', 'level': 3, 'score': 0.55371386}, {'id': 'https://openalex.org/C104292427', 'wikidata': 'https://www.wikidata.org/wiki/Q899781', 'display_name': 'Protein subunit', 'level': 3, 'score': 0.498662}, {'id': 'https://openalex.org/C2779013463', 'wikidata': 'https://www.wikidata.org/wiki/Q1469646', 'display_name': 'Bloom syndrome', 'level': 5, 'score': 0.44191408}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.4003871}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.38776594}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.2539038}, {'id': 'https://openalex.org/C184235292', 'wikidata': 'https://www.wikidata.org/wiki/Q421851', 'display_name': 'Kinase', 'level': 2, 'score': 0.22196916}, {'id': 'https://openalex.org/C161223559', 'wikidata': 'https://www.wikidata.org/wiki/Q138864', 'display_name': 'Helicase', 'level': 4, 'score': 0.21592352}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.16896099}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.14673549}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.11770478}, {'id': 'https://openalex.org/C67705224', 'wikidata': 'https://www.wikidata.org/wiki/Q11053', 'display_name': 'RNA', 'level': 3, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000303', 'descriptor_name': 'Adrenal Cortex Diseases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D001816', 'descriptor_name': 'Bloom Syndrome', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D054756', 'descriptor_name': 'Cyclic AMP-Dependent Protein Kinase RIalpha Subunit', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D004265', 'descriptor_name': 'DNA Helicases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D005347', 'descriptor_name': 'Fibroblasts', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000303', 'descriptor_name': 'Adrenal Cortex Diseases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000303', 'descriptor_name': 'Adrenal Cortex Diseases', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D000303', 'descriptor_name': 'Adrenal Cortex Diseases', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D000303', 'descriptor_name': 'Adrenal Cortex Diseases', 'qualifier_ui': 'Q000150', 'qualifier_name': 'complications', 'is_major_topic': False}, {'descriptor_ui': 'D000306', 'descriptor_name': 'Adrenal Cortex Neoplasms', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D000306', 'descriptor_name': 'Adrenal Cortex Neoplasms', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D000306', 'descriptor_name': 'Adrenal Cortex Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000306', 'descriptor_name': 'Adrenal Cortex Neoplasms', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D000311', 'descriptor_name': 'Adrenal Glands', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000311', 'descriptor_name': 'Adrenal Glands', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D000311', 'descriptor_name': 'Adrenal Glands', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D001816', 'descriptor_name': 'Bloom Syndrome', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D001816', 'descriptor_name': 'Bloom Syndrome', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002460', 'descriptor_name': 'Cell Line', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D054756', 'descriptor_name': 'Cyclic AMP-Dependent Protein Kinase RIalpha Subunit', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D054756', 'descriptor_name': 'Cyclic AMP-Dependent Protein Kinase RIalpha Subunit', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D004265', 'descriptor_name': 'DNA Helicases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004265', 'descriptor_name': 'DNA Helicases', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D005347', 'descriptor_name': 'Fibroblasts', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005786', 'descriptor_name': 'Gene Expression Regulation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006965', 'descriptor_name': 'Hyperplasia', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007150', 'descriptor_name': 'Immunohistochemistry', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010859', 'descriptor_name': 'Pigmentation Disorders', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010859', 'descriptor_name': 'Pigmentation Disorders', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D010859', 'descriptor_name': 'Pigmentation Disorders', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D010859', 'descriptor_name': 'Pigmentation Disorders', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D010859', 'descriptor_name': 'Pigmentation Disorders', 'qualifier_ui': 'Q000150', 'qualifier_name': 'complications', 'is_major_topic': False}, {'descriptor_ui': 'D012333', 'descriptor_name': 'RNA, Messenger', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012333', 'descriptor_name': 'RNA, Messenger', 'qualifier_ui': 'Q000032', 'qualifier_name': 'analysis', 'is_major_topic': False}, {'descriptor_ui': 'D053484', 'descriptor_name': 'RecQ Helicases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1055/s-2008-1058089', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S131832911', 'display_name': 'Hormone and Metabolic Research', 'issn_l': '0018-5043', 'issn': ['0018-5043', '1439-4286'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320000', 'host_organization_name': 'Thieme Medical Publishers (Germany)', 'host_organization_lineage': ['https://openalex.org/P4310320000'], 'host_organization_lineage_names': ['Thieme Medical Publishers (Germany)'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/18401830', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'score': 0.5, 'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W4283367893', 'https://openalex.org/W4237282683', 'https://openalex.org/W4232419554', 'https://openalex.org/W41731184', 'https://openalex.org/W2748952813', 'https://openalex.org/W2398359458', 'https://openalex.org/W2092461227', 'https://openalex.org/W2023511739', 'https://openalex.org/W2014606351', 'https://openalex.org/W1981021342'], 'abstract_inverted_index': {'Bloom': [0, 98, 130], 'syndrome': [1, 99, 131], 'is': [2, 16, 38, 219, 237], 'a': [3, 11, 25, 32, 147, 160, 222], 'genetic': [4], 'disorder': [5], 'associated': [6, 60, 165, 220, 238], 'with': [7, 61, 80, 102, 166, 221, 239], 'chromosomal': [8, 35], 'instability': [9, 36], 'and': [10, 106, 114, 120, 133, 141, 180, 189, 198, 215, 234], 'predisposition': [12], 'to': [13, 184, 230], 'tumors': [14, 30, 43], 'that': [15, 37, 162], 'caused': [17], 'by': [18, 139], 'germline': [19], 'mutations': [20, 105], 'of': [21, 34, 44, 84, 136, 153, 225], 'the': [22, 81, 92, 108], 'BLM': [23, 104, 109, 174, 203, 214, 217, 241], 'gene,': [24], 'RecQ': [26, 75], 'helicase.': [27], 'Benign': [28], 'adrenocortical': [29, 54], 'display': [31], 'degree': [33], 'more': [39], 'significant': [40, 148], 'than': [41], 'benign': [42], 'other': [45, 115, 121, 181, 231], 'tissues.': [46, 118], 'Cortisol-producing': [47], 'hyperplasias,': [48, 182], 'such': [49], 'as': [50, 192, 194], 'primary': [51, 96], 'pigmented': [52], 'nodular': [53], 'disease': [55], '(PPNAD),': [56], 'which': [57, 202], 'has': [58, 163], 'been': [59, 164], 'protein': [62, 122, 151, 175, 242], 'kinase': [63, 123], 'A': [64, 124], '(PKA)': [65, 125], 'abnormalities': [66], 'and/or': [67], 'PRKAR1A': [68, 93, 119, 226, 235], 'mutations,': [69], 'also': [70], 'show': [71], 'genomic': [72], 'instability.': [73], 'Another': [74], 'helicase,': [76], 'WRN,': [77], 'directly': [78], 'interacts': [79], 'PRKAR1B': [82], 'subunit': [83, 140], 'PKA.': [85], 'In': [86], 'this': [87], 'study,': [88], 'we': [89], 'have': [90], 'investigated': [91], 'expression': [94, 111, 137, 152], 'in': [95, 112, 129, 150, 169, 178, 227, 243], 'human': [97], 'cell': [100, 142, 171], 'lines': [101], 'known': [103], 'examined': [107], 'gene': [110], 'PPNAD': [113, 179], 'adrenal': [116, 244], 'tumor': [117], 'subunits': [126, 156], 'were': [127], 'expressed': [128], 'cells': [132], 'their': [134], 'level': [135], 'differed': [138], 'type.': [143], 'Overall,': [144], 'fibroblasts': [145, 228], 'exhibited': [146], 'decrease': [149], 'all': [154], 'PKA': [155, 232], 'except': [157], 'for': [158], 'PRKAR1A,': [159], 'pattern': [161], 'neoplastic': [167], 'transformation': [168], 'several': [170], 'types.': [172], 'The': [173], 'was': [176, 204], 'upregulated': [177], 'compared': [183, 229], 'samples': [185, 195], 'from': [186, 196], 'normal': [187, 190], 'adrenals': [188], 'cortex,': [191], 'well': [193], 'cortisol-': [197], 'aldosterone-producing': [199], 'adenomas': [200], '(in': [201], 'largely': [205], 'absent).': [206], 'These': [207], 'data': [208], 'reveal': [209], 'an': [210], 'inverse': [211], 'relationship': [212], 'between': [213], 'PRKAR1A:': [216], 'deficiency': [218, 236], 'relative': [223], 'excess': [224], 'subunits;': [233], 'increased': [240], 'hyperplasias.': [245]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2093496165', 'counts_by_year': [{'year': 2020, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 1}], 'updated_date': '2024-12-13T02:47:52.297058', 'created_date': '2016-06-24'}