Title: Activity of 13 β-lactam agents combined with BRL 42715 against β-lactamase producing Gram-negative bacteria compared to combinations with clavulanic acid, tazobactam and sulbactam
Abstract: The activity of six cephalosporins, six penicillins and one monobactam combined with BRL 42715, clavulanic acid, sulbactam or tazobactam at 0·1, 0·5, 1, 2, 5 and 10 mg/L was determined for 45 β-lactamase producing Gram-negative bacteria. The combination of BRL 42715 with any of the agents was more active than any of the other inhibitor and β-lactam combinations. Unlike the other β-lactamase inhibitors, BRL 42715 enhanced the activity of the β-lactams for strains that constitutively expressed Richmond & Sykes Class I β-lactamase and against strains expressing extended-spectrum plasmid-mediated β-lactamases.
Publication Year: 1993
Publication Date: 1993-01-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 18
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