Cbl-mediated Degradation of Lyn and Fyn Induced by Constitutive Fibroblast Growth Factor Receptor-2 Activation Supports Osteoblast Differentiation

Name: Work Video:
Duration: 3 min 30 s
Karim Kaabeche; Jérôme Lemonnier; Sandrine Le Mée; Joseph Caverzasio; Pierre J. Marie
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3276, 3335, 3350, 3452, 3472, 3597, 3602, 3682, 3792, 3845, 3855, 3891, 3925, 3991, 4013, 4026, 4034, 4075, 4088, 4127, 4135, 4168, 4189, 4217, 4240, 4285, 4291, 4308, 4337, 4346, 4352, 4358], 'FGF': [17, 47, 257, 287, 1291, 1819], 'signaling': [18, 258, 622, 724, 1146, 1169, 2582], 'mechanisms': [19, 259, 1939], 'controlling': [20, 210, 260, 450, 2375], 'osteoblast': [21, 40, 233, 261, 280, 473, 879, 1016, 1150, 2229, 2299, 2400, 2479, 2708, 2819, 4348], 'function': [22, 262], 'are': [23, 263, 593, 701, 1235, 3009, 4016, 4023], 'poorly': [24, 264], 'understood.': [25, 265], 'Here,': [26, 266], 'we': [27, 267, 983, 2268, 2304, 2349, 3853, 4086, 4115, 4356], 'identified': [28, 268], 'a': [29, 147, 204, 223, 269, 387, 444, 463, 561, 1083, 1166, 1198, 1695, 1806, 2209, 2225, 2371, 2388, 2499, 2963, 3089, 3201, 3213, 3462, 3754, 3861, 4051, 4100, 4117, 4227, 4263, 4362], 'for': [31, 225, 271, 465, 1810, 2390, 2794, 3028, 3143, 3164, 3363, 3376, 3386, 3396, 3474, 3587, 3678, 3719, 3772, 3788, 3863, 3884, 3975], 'Src': [33, 60, 81, 161, 273, 300, 321, 401, 501, 538, 1159, 1182, 1233, 1378, 1386, 1417, 1447, 1686, 1700, 2291, 2566, 2632, 2702, 2740, 2800, 3050, 3073, 3085, 3651, 3850, 3864, 3870, 4063, 4081, 4092, 4107, 4123, 4151, 4184, 4311, 4320, 4339, 4366], 'family': [34, 61, 82, 274, 301, 322, 562, 1160, 1183, 1234, 1379, 1387, 1418, 1701, 2292, 2703, 2741, 3086, 3652, 3851, 3871, 4093, 4108, 4124, 4186, 4340], 'members': [35, 275, 1444, 3653, 3872], 'Lyn': [36, 70, 87, 106, 183, 191, 229, 276, 310, 327, 346, 423, 431, 469, 2316, 2355, 2394, 4193, 4220, 4231, 4243, 4294, 4300, 4325], 'Fyn': [38, 72, 89, 108, 185, 193, 231, 278, 312, 329, 348, 425, 433, 471, 2318, 2357, 2396, 4195, 4222, 4233, 4245, 4302, 4327], 'differentiation': [41, 234, 281, 474, 633, 1017, 2230, 2401, 2820, 4349], 'promoted': [42, 282], 'by': [43, 97, 236, 283, 337, 476, 595, 730, 1153, 1393, 1688, 1940, 2136, 2178, 2215, 2276, 2340, 2403, 2425, 2585, 2711, 2969, 3011, 3040, 3084, 3284, 3319, 3358, 3434, 3445, 3581, 3714, 3782, 3840, 3869, 3985, 3995, 4003, 4074, 4095, 4105, 4156, 4332, 4351], 'constitutive': [44, 178, 237, 284, 418, 477, 804, 2271, 2404], 'activation': [45, 180, 285, 420, 613, 806, 1094, 2272, 2570, 2580, 2619, 2675, 4070], 'of': [46, 80, 101, 155, 228, 286, 320, 341, 395, 468, 563, 608, 614, 619, 629, 673, 722, 741, 1007, 1012, 1143, 1161, 1168, 1231, 1240, 1372, 1377, 1395, 1445, 1685, 1698, 1702, 1952, 2018, 2025, 2055, 2228, 2273, 2290, 2315, 2322, 2366, 2393, 2433, 2478, 2565, 2581, 2671, 2699, 2811, 2818, 2959, 3071, 3082, 3088, 3097, 3100, 3135, 3157, 3170, 3207, 3243, 3280, 3286, 3298, 3310, 3340, 3437, 3481, 3494, 3596, 3615, 3710, 3727, 3735, 3762, 3806, 3844, 3848, 3879, 3928, 3966, 3987, 3999, 4018, 4054, 4071, 4091, 4122, 4182, 4192, 4230, 4242, 4266, 4293, 4319, 4324, 4360, 4365], 'receptor-2': [48, 288], '(FGFR2).': [49, 289], 'We': [50, 290], 'show': [51, 291, 2305, 2350, 4283], 'that': [52, 120, 150, 292, 360, 390, 565, 624, 733, 986, 1085, 1193, 1692, 2219, 2270, 2306, 2332, 2501, 2821, 2967, 3480, 4102, 4149, 4284], 'overactive': [54, 98, 219, 294, 338, 459, 1154, 2216, 2384, 4286, 4353], 'FGFR2': [55, 114, 124, 168, 179, 200, 214, 220, 238, 295, 354, 364, 408, 419, 440, 454, 460, 478, 872, 1008, 1155, 2186, 2212, 2217, 2274, 2277, 2309, 2343, 2361, 2379, 2385, 2405, 2412, 2712, 2826, 3008, 3015, 3018, 3035, 4059, 4072, 4175, 4251, 4272, 4287, 4354], 'S252W': [56, 296, 2310, 4060, 4077, 4137, 4288], 'mutation': [57, 149, 297, 389, 2311, 2344, 2362, 4078, 4138, 4289], 'induced': [58, 96, 235, 298, 336, 475, 1152, 2177, 2214, 2275, 2339, 2402, 2584, 2710, 4073, 4350], 'decreased': [59, 69, 299, 309, 2701, 4179, 4198, 4219, 4228, 4299, 4309], 'kinase': [62, 162, 194, 302, 402, 434, 617, 1092, 1202, 1246, 1388, 1425, 1448, 2175, 2324, 2569, 2704, 2801, 3846, 3875, 3936, 3970, 4146, 4152, 4171, 4180, 4185, 4190, 4223, 4303, 4312, 4341], 'tyrosine': [63, 303, 616, 1163, 1201, 1245, 1704, 1812, 2174, 2633, 2669, 3865, 3874, 3969, 4128], 'phosphorylation': [64, 304, 1376, 2670, 3083, 3868, 4089, 4121], 'activity': [66, 103, 112, 163, 306, 343, 352, 403, 1389, 1426, 2176, 2705, 2802, 3051, 3070, 3288, 3847, 4082, 4153, 4181, 4191, 4224, 4313, 4342], 'associated': [67, 307, 2183], 'with': [68, 86, 126, 134, 144, 146, 308, 326, 366, 374, 384, 386, 598, 698, 1411, 1442, 2184, 2427, 2495, 2549, 2721, 2831, 3023, 3132, 3149, 3154, 3186, 3231, 3251, 3259, 3324, 3329, 3641, 3657, 3670, 3681, 3694, 3798, 3822, 3833, 3890, 3935, 3957, 4050, 4140, 4162, 4203, 4255, 4276], 'protein': [73, 313, 1091, 2143, 3036, 3594, 3604, 3616, 3728, 3763], 'expression': [74, 109, 314, 349, 1011, 2477], 'human': [76, 316, 981, 2280, 2346, 2414, 2827], 'osteoblasts.': [77, 116, 176, 317, 356, 416, 2347], 'Pharmacological': [78, 318, 4317], 'stimulation': [79, 319], 'kinases': [83, 323, 1164, 1184, 1230, 1380, 1419, 1705, 1813, 2634, 2742, 3087, 4094, 4125], 'or': [84, 88, 143, 324, 328, 383, 1400, 2726, 3263, 3267, 3659, 3669, 3686, 3742, 3827, 3913, 4268], 'transfection': [85, 325, 2426, 3281], 'vectors': [90, 330], 'repressed': [91, 331], 'alkaline': [92, 332, 498, 535, 1020, 2336], 'phosphatase': [93, 333, 1021, 2337], '(ALP)': [94, 334], 'up-regulation': [95, 173, 335, 413, 2338], 'FGFR2.': [99, 339, 2367], 'Inhibition': [100, 340], 'proteasome': [102, 186, 342, 426, 2965, 2980, 3013], 'restored': [104, 160, 344, 400], 'normal': [105, 345, 2496], 'ALP': [111, 172, 197, 351, 412, 437, 2813, 4329], 'mutant': [115, 175, 355, 415, 2413, 2473, 2828, 3016, 3019, 4084, 4159, 4176, 4200, 4252, 4273, 4315], 'Immunoprecipitation': [117, 357], 'studies': [118, 358], 'showed': [119, 359, 4262], 'Lyn,': [121, 165, 211, 361, 405, 451, 1453, 2376, 3005, 3032, 3264], 'Fyn,': [122, 166, 212, 362, 406, 452, 1452, 2377, 3006, 3033, 3265, 4296], 'interacted': [125, 365], 'ubiquitin': [128, 368, 2057], 'ligase': [129, 369, 1809], 'c-Cbl': [130, 135, 145, 370, 375, 385, 1439, 1693, 1802, 1942, 1948, 2019, 2042, 2207], 'ubiquitin.': [132, 372], 'Transfection': [133, 373], 'which': [137, 377, 700, 1941, 2038, 2052, 2294, 2630, 2737, 3181, 3648, 3858, 4305], 'RING': [139, 379, 2050], 'finger': [140, 380], 'was': [141, 381, 2221, 2803, 2929, 3052, 3282, 3301, 3432, 3477, 3599, 3983, 4001, 4154, 4196, 4211, 4247], 'disrupted': [142, 382], 'point': [148, 388, 989], 'abolishes': [151, 391], 'binding': [153, 393, 605, 1394, 1827, 2043, 2970], 'ability': [154, 394], 'Cbl': [157, 397, 2135, 3268], 'phosphotyrosine-binding': [158, 398, 2035], 'domain': [159, 399, 1203, 1414], 'levels': [169, 409, 3037, 3309, 3709], 'reduced': [171, 190, 411, 430, 4155, 4249, 4338], 'Thus,': [177, 417], 'induces': [181, 421, 606, 2363], 'c-Cbl-dependent': [182, 422, 2313, 2364], 'degradation,': [187, 427], 'resulting': [188, 428, 611, 1821, 4297], 'activity,': [195, 435, 2814, 4304], 'increased': [196, 436, 2185, 2399, 2476, 2489, 2824], 'expression,': [198, 438], 'down-regulation.': [201, 441], 'This': [202, 442, 1678, 2326, 2368], 'reveals': [203, 443, 2370], 'common': [205, 445, 2372], 'Cbl-mediated': [206, 446], 'negative': [207, 447, 1696, 1945, 2023, 2226], 'feedback': [208, 448], 'mechanism': [209, 449, 2139, 2374, 2666], 'degradation': [215, 455, 1684, 2213, 2289], 'response': [217, 457, 2382], 'to': [218, 458, 560, 626, 875, 1398, 1409, 1681, 2032, 2044, 2223, 2297, 2354, 2383, 2504, 2576, 2622, 2972, 3066, 3200, 3275, 3334, 3451, 3479, 3813, 4009, 4130, 4214, 4307, 4345], 'indicates': [222, 462, 2387], 'Cbl-dependent': [226, 466, 2373, 2391], 'down-regulation': [227, 467, 1824, 2187, 2314, 2380, 2392], 'activation.': [239, 479], '1The': [484], 'abbreviations': [485, 522], 'used': [486, 523, 3375, 3854], 'are:': [487, 524], 'FGF,': [488, 525], 'fibroblast': [489, 493, 526, 530], 'factor;': [491, 506, 510, 528, 543, 547], 'FGFR,': [492, 529], 'factor': [495, 532, 1251, 1269], 'receptor;': [496, 533], 'ALP,': [497, 534, 2484, 3313, 3364, 3397], 'phosphatase;': [499, 536], 'SH,': [500, 537], 'homology;': [502, 539], 'EGF,': [503, 540, 1816], 'epidermal': [504, 541, 1249], 'PDGF,': [507, 544, 1817], 'platelet-derived': [508, 545, 1267], 'PTB,': [511, 548], 'phosphotyrosine-binding;': [512, 549], 'LPA,': [513, 550, 4361], 'lysophosphatidic': [514, 551, 2589], 'acid;': [515, 552], 'RT,': [516, 553], 'reverse': [517, 554], 'transcription;': [518, 555], 'GAPDH,': [519, 556], 'glyceraldehyde-3-phosphate': [520, 557, 3369], 'dehydrogenase.1The': [521], 'dehydrogenase.': [558], 'belong': [559], 'polypeptides': [564], 'regulate': [566], 'cell': [567, 574, 630], 'proliferation,': [568, 880], 'differentiation,': [569, 881], 'survival': [571, 883], 'many': [573], 'types': [575], '(1Givol': [576], 'D.': [577, 640, 748, 750, 756, 822, 824, 830, 895, 917, 968, 1048, 1069, 1124, 1786, 1964, 2460, 2525, 2848, 2869, 2912, 2947, 3413], 'Yayon': [578], 'A.': [579, 921, 936, 955, 966, 1035, 1046, 1067, 1096, 1122, 1278, 1428, 1538, 1574, 1621, 1623, 1625, 1770, 1772, 1893, 1911, 1915, 1921, 1928, 1995, 2088, 2096, 2146, 2150, 2156, 2163, 2242, 2256, 2447, 2458, 2523, 2835, 2846, 2867, 2884, 2910, 2934, 2945, 3411], 'FASEB': [580], 'J.': [581, 784, 858, 891, 897, 943, 957, 971, 1037, 1051, 1061, 1098, 1103, 1116, 1126, 1129, 1314, 1350, 1355, 1485, 1553, 1577, 1632, 1753, 1782, 1784, 1791, 1837, 1838, 1864, 1894, 1917, 2067, 2099, 2152, 2192, 2257, 2449, 2463, 2517, 2594, 2598, 2601, 2640, 2649, 2685, 2752, 2772, 2837, 2851, 2861, 2886, 2891, 2904, 2914, 2917, 2936, 2950, 2986, 3405, 3415, 3418, 3529, 3533, 3535, 3536, 3555, 3562], '1992;': [582, 644], '6:': [583], '3362-3369Crossref': [584], 'PubMed': [585, 647, 691, 715, 766, 790, 816, 840, 864, 909, 930, 949, 977, 1057, 1078, 1110, 1136, 1177, 1210, 1224, 1262, 1285, 1301, 1323, 1340, 1366, 1474, 1496, 1509, 1542, 1564, 1588, 1643, 1673, 1731, 1764, 1797, 1849, 1875, 1905, 1932, 2010, 2078, 2110, 2127, 2167, 2198, 2263, 2469, 2534, 2612, 2660, 2690, 2757, 2783, 2857, 2878, 2898, 2924, 2956, 2997, 3425, 3547, 3573], 'Scopus': [586, 648, 692, 716, 767, 791, 817, 841, 865, 910, 931, 950, 1079, 1111, 1137, 1178, 1211, 1225, 1263, 1286, 1341, 1367, 1475, 1497, 1510, 1543, 1565, 1589, 1612, 1644, 1674, 1732, 1765, 1798, 1850, 1876, 1906, 1933, 1972, 2011, 2079, 2111, 2128, 2168, 2199, 2264, 2535, 2613, 2661, 2691, 2758, 2784, 2879, 2899, 2925, 2998, 3426, 3548, 3574], '(398)': [587], 'Google': [588, 650, 694, 718, 769, 793, 819, 843, 867, 912, 933, 952, 978, 1058, 1081, 1113, 1139, 1180, 1213, 1227, 1265, 1288, 1302, 1324, 1343, 1369, 1437, 1477, 1499, 1512, 1545, 1567, 1591, 1614, 1646, 1676, 1734, 1767, 1800, 1852, 1878, 1908, 1935, 1974, 2013, 2081, 2113, 2130, 2170, 2201, 2266, 2470, 2537, 2615, 2663, 2693, 2760, 2786, 2858, 2881, 2901, 2927, 2957, 3000, 3428, 3550, 3576], 'Scholar).': [589, 651, 719, 794, 868, 979, 1140, 1181, 1228, 1370, 1438, 1677, 1801, 1936, 2014, 2131, 2171, 2471, 2538, 2616, 2664, 2694, 2787, 3001, 3429, 3577], 'These': [590, 4281], 'biological': [591], 'effects': [592], 'mediated': [594, 1087], 'ligand': [596, 1826], 'interaction': [597, 1679], 'high': [599], 'affinity': [600], 'cell-surface': [601], 'receptors': [602, 1374, 1954, 2029], '(FGFRs).': [603], 'Ligand': [604], 'dimerization': [607], 'receptor,': [610, 2047], 'intrinsic': [615, 1384, 2173], 'multiple': [620, 1243, 1396], 'downstream': [621], 'processes': [623], 'contribute': [625, 2296, 4344], 'regulation': [628, 1946, 2024], 'several': [635, 734, 1443, 2623, 4183], 'tissues': [636], '(2Basilico': [637], 'C.': [638, 919, 942, 1307, 1572, 1778, 3531], 'Moscatelli': [639], 'Adv.': [641], 'Cancer': [642], 'Res.': [643, 1074, 1106, 1132, 1281, 1469, 2530, 2874, 2894, 2920, 3421], '59:': [645], '115-165Crossref': [646], '(1049)': [649], 'In': [652, 980, 2301, 4258], 'bone,': [653], 'FGFs': [654], 'essential': [656], 'roles': [657], 'postnatal': [662], 'osteogenesis': [663], '(3Hurley': [664], 'M.M.': [665], 'Marie': [666, 708, 809, 969, 1049, 1070, 1101, 1127, 2461, 2526, 2849, 2870, 2889, 2915, 2948, 3416, 3560], 'P.J.': [667, 685, 709, 810, 970, 1050, 1071, 1102, 1128, 2462, 2527, 2850, 2871, 2890, 2916, 2949, 3417, 3561], 'Florkiewicz': [668], 'R.Z.': [669], '2nd': [670], 'Ed.': [671], 'Principles': [672], 'Bone': [674, 924, 1104, 1130, 2892, 2918, 3419], 'Biology.': [675], '1.': [676], 'Academic': [677], 'Press,': [678], 'Inc.,': [679, 4041], 'New': [680], 'York2001:': [681], '825-851Google': [682], 'Scholar,': [683, 770, 820, 844, 913, 934, 953, 1059, 1114, 1214, 1303, 1325, 1344, 1478, 1500, 1513, 1546, 1568, 1592, 1615, 1647, 1735, 1768, 1853, 1879, 1909, 1975, 2082, 2114, 2761, 2859, 2882, 2902, 3551], '4Marie': [684], 'Gene': [686], '(Amst.).': [687], '2003;': [688, 906, 927, 1221, 1259, 1358, 2604], '316:': [689], '23-32Crossref': [690], '(232)': [693], 'Scholar)': [695], 'through': [696, 1090], 'interactions': [697, 1196], 'FGFR1–3,': [699], 'differentially': [702], 'expressed': [703, 4024], 'during': [704, 3924], '(5Ornitz': [706, 807], 'D.M.': [707, 808, 903, 1346], 'Genes': [710, 811, 1607], 'Dev.': [711, 812], '2002;': [712, 787, 813, 861, 1539, 1609, 1867, 1929, 2164], '16:': [713, 814, 1108, 1134, 2896, 2922, 3423], '1446-1465Crossref': [714, 815], '(712)': [717, 818], 'The': [720, 1141, 1403, 1937, 2015, 2539, 3075, 3227, 3296, 3372, 3394, 3636, 3708, 3981, 3997, 4021, 4145], 'importance': [721], 'FGFR': [723, 796, 1145, 2132, 2180], 'formation': [727], 'is': [728, 1086, 1390, 1694, 2039, 2182, 2204, 2328, 2502, 2571, 2620, 2822, 2962, 3078, 4103], 'exemplified': [729], 'finding': [732], 'mutations': [735, 797, 870, 990, 1156, 2181, 2278], 'FGFRs': [737], 'induce': [738, 876], 'premature': [739, 2298, 4347], 'ossification': [740], 'cranial': [742], 'sutures': [743, 2513], '(craniosynostosis)': [744], 'humans': [746, 887], '(6Burke': [747], 'Wilkes': [749, 823], 'Blundell': [751, 825], 'T.L.': [752, 826], 'Malcom': [753, 827], 'S.': [754, 828, 1327, 1480, 1517, 1537, 1594, 1627, 1658, 1716, 1746, 1857, 1881, 1889, 1927, 1989, 1997, 2162, 2189, 2191, 2238, 2240, 2244, 2681, 2748], 'Burke': [755, 829], 'Trends': [757, 831], 'Biochem.': [758, 832, 1467], 'Sci.': [759, 833, 1535, 1925, 2160], '1998;': [760, 834, 974, 1054, 1174, 1207, 1556, 1580, 1756, 2195, 2466, 2854, 2953, 2989], '23:': [761, 835], '59-62Abstract': [762, 836], 'Full': [763, 837, 1320, 1361, 1363, 1491, 1493, 1559, 1561, 1583, 1585, 1638, 1640, 1759, 1761, 1844, 1846, 1870, 1872, 1900, 1902, 2005, 2007, 2073, 2075, 2105, 2107, 2607, 2609, 2655, 2657, 2778, 2780, 2992, 2994, 3542, 3544, 3568, 3570], 'Text': [764, 838, 1321, 1362, 1364, 1492, 1494, 1560, 1562, 1584, 1586, 1639, 1641, 1760, 1762, 1845, 1847, 1871, 1873, 1901, 1903, 2006, 2008, 2074, 2076, 2106, 2108, 2608, 2610, 2656, 2658, 2779, 2781, 2993, 2995, 3543, 3545, 3569, 3571], 'PDF': [765, 839, 1322, 1365, 1495, 1563, 1587, 1642, 1763, 1848, 1874, 1904, 2009, 2077, 2109, 2611, 2659, 2782, 2996, 3546, 3572], '(153)': [768, 842], '7Wilkie': [771, 845], 'A.O.': [772, 846], 'Patey': [773, 847], 'S.J.': [774, 848, 1504], 'Kan': [775, 849], 'S.H.': [776, 850], 'van': [777, 851], 'den': [778, 852], 'Ouweland': [779, 853], 'A.M.': [780, 854], 'Hamel': [781, 855], 'B.C.': [782, 856], 'Am.': [783, 857], 'Med.': [785, 859], 'Genet.': [786, 860], '112:': [788, 862], '266-278Crossref': [789, 863], '(160)': [792, 866], 'Most': [795], 'result': [798, 2283], 'ligand-independent': [800], 'dimerization,': [801], 'phosphorylation,': [802], 'receptor': [805, 1811, 2592, 2618, 2730], '6Burke': [821], 'Gain-of-function': [869], 'were': [873, 2030, 2423, 2541, 2719, 2792, 3021, 3038, 3105, 3152, 3174, 3182, 3198, 3218, 3229, 3257, 3317, 3322, 3347, 3353, 3378, 3388, 3401, 3459, 3488, 3579, 3618, 3627, 3638, 3712, 3730, 3768, 3779, 3794, 3810, 3820, 3831, 3882, 3922, 3931, 3993, 4006, 4031, 4048], 'found': [874, 2031, 2222], 'changes': [877], 'mice': [885, 2232], '(8Yu': [888], 'K.': [889, 1596, 1600, 1604, 1991], 'Xu': [890], 'Liu': [892, 1575, 1965], 'Z.': [893], 'Sosic': [894], 'Shao': [896], 'Olson': [898], 'E.N.': [899], 'Towler': [900], 'D.A.': [901], 'Ornitz': [902], 'Development': [904], '(Camb.).': [905], '130:': [907], '3063-3074Crossref': [908], '(511)': [911], '9Chen': [914], 'L.': [915, 1295, 1774], 'Li': [916, 918, 1920, 2155], 'Engel': [920], 'Deng': [922], 'C.X.': [923], '(N.': [925], 'Y.).': [926], '33:': [928], '169-178Crossref': [929], '(135)': [932], '10Mansukhani': [935], 'Bellosta': [937], 'P.': [938, 1065, 1100, 1120, 1293, 1521, 1527, 1859, 2521, 2636, 2865, 2888, 2908, 3409], 'Sahni': [939], 'M.': [940, 959, 1039, 1063, 1331, 1333, 1570, 1617, 1983, 2084, 2090, 2234, 2451, 2519, 2638, 2839, 2863, 2938], 'Basilico': [941], 'Cell': [944, 1073, 1280, 1792, 2258, 2529, 2873], 'Biol.': [945, 1315, 1356, 1486, 1554, 1578, 1633, 1669, 1727, 1754, 1793, 1839, 1865, 1895, 2068, 2100, 2123, 2259, 2602, 2650, 2773, 2987, 3537, 3563], '2000;': [946, 1075, 1670, 1728, 1897, 2260, 2531, 2652, 2875], '149:': [947], '1297-1308Crossref': [948], '(264)': [951], '11Lomri': [954], 'Lemonnier': [956, 1036, 1097, 2448, 2836, 2885, 2935, 3554], 'Hott': [958, 1038, 1062, 2450, 2518, 2838, 2862, 2937], 'de': [960, 1040, 2452, 2840, 2939], 'Perseval': [961, 1041, 2453, 2841, 2940], 'N.': [962, 1042, 1515, 1740, 2454, 2842, 2941], 'Lajeunie': [963, 1043, 2455, 2843, 2942], 'E.': [964, 1044, 1118, 1776, 1780, 2456, 2600, 2844, 2906, 2943, 3407, 3553], 'Munnich': [965, 1045, 2457, 2845, 2944], 'Renier': [967, 1047, 2459, 2847, 2946], 'Clin.': [972, 1052, 2464, 2852, 2951], 'Investig.': [973, 1053, 2465, 2853, 2952], '101:': [975, 1055, 2467, 2855, 2954], '1310-1317Crossref': [976, 1056, 2468, 2856, 2955], 'osteoblasts,': [982, 3017, 4085], 'have': [984, 1185], 'shown': [985, 1408, 2575, 4111, 4236], 'single': [987], 'missense': [988], '(S252W': [991], 'P253R)': [993], 'located': [994], 'linker': [997], 'region': [998], 'between': [999, 4045], 'second': [1001], 'third': [1003], 'extracellular': [1004], 'immunoglobulin': [1005], 'domains': [1006, 1192, 2017], 'activate': [1009, 2631, 2739], 'early': [1013, 2573, 2816], 'late': [1015], 'genes,': [1018], 'including': [1019, 1248, 1450], '(ALP),': [1022], 'type': [1023], 'I': [1024], 'collagen': [1025], '(COLIA1),': [1026], 'osteocalcin': [1028, 2487], 'vitro': [1030, 2491, 4170], 'vivo': [1033, 2515], '(11Lomri': [1034, 2446, 2834, 2933], '12Lemonnier': [1060, 2860], 'Delannoy': [1064, 1099, 1119, 2520, 2864, 2887, 2907, 3408], 'Lomri': [1066, 1121, 2522, 2866, 2909, 3410], 'Modrowski': [1068, 1123, 2524, 2868, 2911, 3412], 'Exp.': [1072, 1279, 2528, 2872], '256:': [1076, 2532, 2876], '158-167Crossref': [1077, 2533, 2877], '(68)': [1080, 2536, 2880], 'Scholar),': [1082, 1266, 1289, 2202, 2267, 2928], 'phenotype': [1084, 1151, 2500, 2709], 'part': [1089], 'C': [1093], '(13Lomri': [1095], 'Miner.': [1105, 1131, 2893, 2919, 3420], '2001;': [1107, 1133, 1435, 1635, 1794, 2124, 2895, 2921, 3422], '705-712Crossref': [1109, 2897], '(57)': [1112, 2900], '14Lemonnier': [1115, 2903], 'Haÿ': [1117, 2905, 3406], 'Caverzasio': [1125, 2913, 3414, 3534], '832-845Crossref': [1135, 2923, 3424], '(66)': [1138, 2926, 3427], 'other': [1144], 'pathways': [1147, 1170, 2583], 'remains': [1157], 'unknown.The': [1158], 'non-receptor': [1162, 1703], 'mediates': [1165], 'variety': [1167], '(15Schwartzberg': [1171, 1204], 'P.L.': [1172, 1205], 'Oncogene.': [1173, 1206, 1336, 1505], '17:': [1175, 1208], '1463-1468Crossref': [1176, 1209], '(132)': [1179, 1212], 'unique': [1186], 'N-terminal': [1187, 2975], 'SH2': [1189, 1399], 'SH3': [1191, 1401, 1413], 'mediate': [1194], 'protein/protein': [1195], 'C-terminal': [1199], 'SH1': [1200], '16Leu': [1215], 'T.H.': [1216, 1254], 'Maa': [1217, 1255], 'M.C.': [1218, 1256], 'Front.': [1219, 1257, 1296], 'Biosci.': [1220, 1258, 1297], '8:': [1222, 1260, 1610], 'S28-S38Crossref': [1223, 1261], '(61)': [1226, 1264], 'Protein-tyrosine': [1229], 'involved': [1236, 2020, 2040, 2578], 'transduction': [1239], 'signals': [1241, 3458], 'from': [1242, 2418, 3344, 4226], 'transmembrane': [1244], 'receptors,': [1247, 1820], '(EGF)': [1252], '(16Leu': [1253], '(PDGF)': [1270], '(17DeMali': [1271], 'K.A.': [1272], 'Godwin': [1273], 'S.L.': [1274, 2985], 'Soltoff': [1275], 'S.P.': [1276], 'Kazauskas': [1277], '1999;': [1282, 1298, 1471, 1488, 1969, 2002, 2070, 2102, 2775], '253:': [1283], '271-279Crossref': [1284], '(50)': [1287], '(18Klint': [1292], 'Claesson-Welsh': [1294], '4:': [1299, 2003], 'D165-D177Crossref': [1300], '19Zhan': [1304], 'X.': [1305, 1309, 1598], 'Plourde': [1306], 'Hu': [1308], 'Friesel': [1310], 'R.': [1311, 1335, 1432, 1631, 1790, 2098, 2254], 'Maciag': [1312], 'T.': [1313, 1619, 2086, 2246, 2248, 2771], 'Chem.': [1316, 1357, 1487, 1555, 1579, 1634, 1755, 1840, 1866, 1896, 2069, 2101, 2603, 2651, 2774, 2988, 3538, 3564], '1994;': [1317], '269:': [1318], '20221-20224Abstract': [1319], '20Yayon': [1326], 'Ma': [1328], 'Y.S.': [1329], 'Safran': [1330], 'Klagsbrun': [1332], 'Halaban': [1334], '1997;': [1337, 1506], '14:': [1338, 1507], '2999-3009Crossref': [1339], '(67)': [1342], '21Kilkenny': [1345], 'Rocheleau': [1347], 'J.V.': [1348], 'Price': [1349], 'Reich': [1351], 'M.B.': [1352], 'Miller': [1353], 'G.G.': [1354], '278:': [1359, 2605], '17448-17454Abstract': [1360], '(33)': [1368], 'Activation': [1371, 4318], 'these': [1373], 'causes': [1375], 'increases': [1382], 'their': [1383, 1424, 1823, 2323], 'activity.': [1385, 2325, 3876], 'also': [1391, 1803], 'controlled': [1392, 3283], 'proteins': [1397, 1687, 2626, 3487, 3626, 3711, 3881, 4246], 'domains.': [1402], 'proto-oncogene': [1404], 'c-cbl': [1405], 'has': [1406], 'been': [1407], 'associate': [1410], 'some': [1416], 'thereby': [1421], 'may': [1422, 2282, 2295, 4343], 'control': [1423, 2421, 2444, 2497, 2715, 2790, 2832, 3239, 4141, 4163, 4204, 4256, 4277], '(22Sanjay': [1427], 'Horne': [1429, 1787, 2091], 'W.C.': [1430, 1788, 2092], 'Baron': [1431, 1630, 1789, 2097, 2253], "Science's": [1433], 'STKE.': [1434], '(http://stke.sciencemag.org/cgi/content/full/sigtrans;2001/110/pe40)PubMed': [1436], 'can': [1440, 2133, 2738], 'interact': [1441], 'family,': [1449], 'c-Src,': [1451], 'Yes,': [1454], 'Syk': [1456], '(23Howlett': [1457], 'C.J.': [1458], 'Bisson': [1459], 'S.A.': [1460, 1981, 2683, 2750], 'Resek': [1461], 'M.E.': [1462], 'Tigley': [1463], 'A.W.': [1464], 'Robbins': [1465], 'S.M.': [1466, 1602, 1863], 'Biophys.': [1468], 'Commun.': [1470], '257:': [1472], '129-138Crossref': [1473], '(26)': [1476], '24Hunter': [1479], 'Burton': [1481], 'E.A.': [1482, 1548, 1748], 'Wu': [1483], 'S.C.': [1484], '274:': [1489, 2071, 2103, 2776], '2097-2106Abstract': [1490], '(118)': [1498], '25Dombrosky-Ferlan': [1501], 'P.M.': [1502], 'Corey': [1503], '2019-2024Crossref': [1508], '(40)': [1511, 1613], '26Rao': [1514], 'Miyake': [1516, 1745, 1888], 'Reddi': [1518], 'A.L.': [1519], 'Douillard': [1520], 'Ghosh': [1522], 'A.K.': [1523], 'Dodge': [1524], 'I.L.': [1525], 'Zhou': [1526], 'Fernandes': [1528], 'N.D.': [1529], 'Band': [1530, 1665, 1723, 1890], 'H.': [1531, 1606, 1629, 1666, 1724, 1752, 1891, 1960, 1979, 2060, 2094, 2763, 3559], 'Proc.': [1532, 1922, 2157], 'Natl.': [1533, 1923, 2158], 'Acad.': [1534, 1924, 2159], 'U.': [1536, 1926, 2161], '99:': [1540, 1930, 2165], '3794-3799Crossref': [1541], '(110)': [1544], '27Feshchenko': [1547], 'Langdon': [1549, 1663, 1721, 1834, 2117], 'W.Y.': [1550, 1664, 1722, 1835, 2118], 'Tsygankov': [1551, 1984], 'A.Y.': [1552, 1985], '273:': [1557, 1581, 1757, 2990], '8323-8331Abstract': [1558], '(146)': [1566], '28Deckert': [1569], 'Elly': [1571], 'Altman': [1573], 'Y.C.': [1576, 1966], '8867-8874Abstract': [1582], '(105)': [1590], '29Kyo': [1593], 'Sada': [1595], 'Qu': [1597], 'Maeno': [1599], 'Miah': [1601], 'Kawauchi-Kamata': [1603], 'Yamamura': [1605], 'Cells.': [1608], '825-836Crossref': [1611], '30Yokouchi': [1616], 'Kondo': [1618, 2085], 'Sanjay': [1620], 'Houghton': [1622, 1771, 2087], 'Yoshimura': [1624, 2095], 'Komiya': [1626], 'Zhang': [1628, 2093], '276:': [1636], '35185-35193Abstract': [1637], '(181)': [1645], '31Andoniou': [1648], 'C.E.': [1649, 1707, 1744], 'Lill': [1650, 1708, 1741], 'N.L.': [1651, 1709, 1742], 'Thien': [1652, 1710], 'C.B.': [1653, 1711, 2116], 'Lupher': [1654, 1712], 'Jr.,': [1655, 1713, 1737], 'M.L.': [1656, 1714, 1738, 1829], 'Ota': [1657, 1715], 'Bowtell': [1659, 1717, 1785], 'D.D.': [1660, 1718], 'Scaife': [1661, 1719], 'R.M.': [1662, 1720], 'Mol.': [1667, 1725, 2000, 2121], 'Cell.': [1668, 1726, 2001, 2122], '20:': [1671, 1729], '851-867Crossref': [1672, 1730], '(98)': [1675, 1733, 1877], 'leads': [1680], 'ubiquitination': [1682, 2365], 'proteasome,': [1690], 'showing': [1691], 'regulator': [1697, 2227], '(31Andoniou': [1706], '32Lupher': [1736], 'Rao': [1739], 'Andoniou': [1743], 'Clark': [1747], 'Druker': [1749], 'B.': [1750, 1913, 2148], 'Ban': [1751], '35273-35281Abstract': [1758], '(154)': [1766], '33Sanjay': [1769], 'Neff': [1773], 'DiDomenico': [1775], 'Bardelay': [1777], 'Antoine': [1779], 'Levy': [1781], 'Gailit': [1783], '152:': [1795], '181-195Crossref': [1796], '(336)': [1799], 'acts': [1804, 2968], 'as': [1805, 1815, 2437, 2483, 2628, 2805, 2931, 3044, 3402, 3815, 3860, 4025], 'ubiquitin-protein': [1807], 'isopeptide': [1808], 'such': [1814, 2482, 2627], 'after': [1825], '(34Galisteo': [1828], 'Dikic': [1830], 'I.': [1831, 1919, 1987, 2064, 2154, 2677, 2744], 'Batzer': [1832], 'A.G.': [1833], 'Schlessinger': [1836, 1916, 2151, 2684, 2751], '1995;': [1841], '270:': [1842], '20242-20245Abstract': [1843], '(174)': [1851], '35Kassenbrock': [1854], 'C.K.': [1855], 'Hunter': [1856, 1963], 'Garl': [1858], 'Johnson': [1860], 'G.L.': [1861], 'Anderson': [1862], '277:': [1868], '24967-24975Abstract': [1869], '36Rosenkranz': [1880], 'Ikuno': [1882], 'Y.': [1883, 1993, 1999, 2066], 'Leong': [1884], 'F.L.': [1885], 'Klinghoffer': [1886], 'R.A.': [1887], 'Kaslauskas': [1892], '275:': [1898, 2653], '9620-9627Abstract': [1899], '(53)': [1907], '37Wong': [1910], 'Lamothe': [1912, 2147], 'Lee': [1914, 2149], 'Las': [1918, 2153], '6684-6689Crossref': [1931, 2166], '(141)': [1934, 2169], 'molecular': [1938], 'exerts': [1943], 'this': [1944, 2302], 'involve': [1947], 'recruitment': [1949, 2054, 2287], 'polyubiquitination': [1951], 'activated': [1953, 2046], '(38Joazeiro': [1955], 'C.A.': [1956], 'Wing': [1957], 'S.S.': [1958], 'Huang': [1959, 2766], 'Leverson': [1961], 'J.D.': [1962], 'Science': [1967], '2.': [1968], '86:': [1970], '309-312Crossref': [1971], '(909)': [1973], '39Levkowitz': [1976], 'G.': [1977, 2062, 2679, 2746, 2983], 'Waterman': [1978], 'Ettenberg': [1980], 'Katz': [1982], 'Alroy': [1986, 2063], 'Lavi': [1988], 'Iwai': [1990], 'Reiss': [1992], 'Ciechanover': [1994], 'Lipkowitz': [1996], 'Yarden': [1998, 2065], '1029-1040Abstract': [2004], '(829)': [2012], 'EGF': [2026], 'PDGF': [2028], 'be': [2033, 2224, 2577], '(PTB)': [2036], 'domain,': [2037], 'finger,': [2051], 'directs': [2053], 'system': [2058], '(40Waterman': [2059], 'Levkowitz': [2061], '22151-22154Abstract': [2072], '(259)': [2080], '41Yokouchi': [2083], 'Bartkiewicz': [2089], '31707-31712Abstract': [2104], '(283)': [2112], '42Thien': [2115], 'Nat.': [2119], 'Rev.': [2120], '2:': [2125], '294-307Crossref': [2126], '(514)': [2129], 'recruit': [2134], 'another': [2137], 'indirect': [2138], 'involving': [2140], 'docking': [2142], 'FRS2α': [2144], '(37Wong': [2145], 'Although': [2172], 'gain-of-function': [2179, 4076], '(43Bresnick': [2188], 'Schendel': [2190], 'Craniofac.': [2193], 'Surg.': [2194], '9:': [2196], '92-95Crossref': [2197], '(11)': [2200], 'it': [2203, 2333], 'unknown': [2205], 'if': [2206], 'plays': [2208], 'mutations.Given': [2218], 'c-Src': [2220, 2674], '(44Marzia': [2233], 'Sims': [2235], 'N.A.': [2236], 'Voit': [2237], 'Migliaccio': [2239], 'Taranta': [2241], 'Bernardini': [2243], 'Faraggiana': [2245], 'Yoneda': [2247], 'Mundy': [2249], 'G.R.': [2250], 'Boyce': [2251], 'B.F.': [2252], 'Teti': [2255], '151:': [2261], '311-320Crossref': [2262], '(246)': [2265], 'hypothesized': [2269], 'osteoblasts': [2281, 2718, 2829, 4160, 4177, 4253], 'alterations': [2285], 'kinases,': [2293], 'differentiation.': [2300], 'work,': [2303], 'activating': [2308, 2342, 2360, 4136], 'enhances': [2312], 'subsequent': [2320], 'inhibition': [2321], 'effect': [2327, 4359], 'biologically': [2329], 'relevant': [2330], 'reduces': [2334, 4290], 'Moreover,': [2348], 'that,': [2351], 'addition': [2353, 3986], 'down-regulation,': [2358], 'study': [2369], 'activation.EXPERIMENTAL': [2406], 'PROCEDURESCell': [2407], 'Lines': [2408], 'Culture—Normal': [2410], 'calvaria': [2415], 'cells': [2416, 2445, 2474, 2540, 2791, 2833, 3020, 3217, 3228, 3300, 4133, 4142, 4164, 4201, 4205, 4274, 4278], 'obtained': [2417], 'Apert': [2419, 2442, 2472, 2511, 2717, 2788], 'fetuses': [2422], 'immortalized': [2424], 'origin-defective': [2429], 'large': [2430], 'T': [2431], 'antigen': [2432], 'SV40': [2435], 'oncogene': [2436], 'described': [2438, 2806, 2932, 3045, 3403, 3816], 'previously': [2439], 'called': [2441], 'display': [2475], 'marker': [2480, 2817], 'genes': [2481], 'COLIA1,': [2485, 3365, 3398], 'osteogenic': [2492], 'capacity': [2493], 'compared': [2494, 2830, 4139, 4161, 4202, 4254, 4275], 'cells,': [2498], 'similar': [2503, 4264], 'pathological': [2506], 'features': [2507], 'observed': [2508, 4116, 4218], 'fetal': [2510, 2555, 3253], 'coronal': [2512], '(12Lemonnier': [2516], 'cultured': [2542], "Dulbecco's": [2544, 3247], 'modified': [2545, 3248], "Eagle's": [2546, 3249], 'medium': [2547, 3250], 'supplemented': [2548], '292': [2550], 'mg/liter': [2551], 'glutamine,': [2552], '10%': [2553], 'heat-inactivated': [2554], 'calf': [2556, 3254], 'serum,': [2557], '100': [2558, 2562], 'IU/ml': [2559], 'penicillin,': [2560], 'μg/ml': [2563, 3511, 3514], 'streptomycin.Stimulation': [2564], 'Kinase': [2567, 3048, 4064], 'Activity—Src': [2568], 'event': [2574], 'G': [2587, 2625], 'protein-coupled': [2588], 'acid': [2590, 3160], '(LPA)': [2591], '(47Yuan': [2593], 'Slice': [2595], 'L.W.': [2596], 'Gu': [2597], 'Rozengurt': [2599], '4882-4891Abstract': [2606], '(54)': [2614], 'LPA': [2617, 2722], 'coupled': [2621], 'heterotrimeric': [2624], 'Gi,': [2629], '(48Maschberger': [2635], 'Bauer': [2637], 'Baumann-Siemons': [2639], 'Zangl': [2641], 'K.J.': [2642], 'Negrescu': [2643], 'E.V.': [2644], 'Reininger': [2645], 'A.J.': [2646], 'Siess': [2647], 'W.': [2648], '19159-19166Abstract': [2654], '(75)': [2662], 'One': [2665], 'involves': [2667], 'LPA-induced': [2668], 'Pyk2': [2672], '(49Dikic': [2676, 2743], 'Tokiwa': [2678, 2745], 'Lev': [2680, 2747], 'Courtneidge': [2682, 2749], 'Nature.': [2686, 2753], '1996;': [2687, 2754], '383:': [2688, 2755], '547-550Crossref': [2689, 2756], '(876)': [2692, 2759], 'To': [2695, 3002], 'determine': [2696, 3003, 4335], 'activation,': [2713], 'confluent': [2714], 'treated': [2720, 2793, 3022], '(10': [2723, 2734, 3025, 3103], 'μm;': [2724, 2735, 3026], 'Sigma)': [2725, 3674], 'selective': [2728], 'α2A-adrenergic': [2729], 'agonist': [2731], 'UK': [2732], '14,304': [2733], 'Sigma),': [2736], '50Tang': [2762], 'Zhao': [2764], 'Z.J.': [2765], 'X.Y.': [2767], 'Landon': [2768], 'E.J.': [2769], 'Inagami': [2770], '12401-12407Abstract': [2777], '(23)': [2785], '24': [2795, 2809, 3029, 3303, 3758], 'h,': [2796, 3030, 3759], 'then': [2798, 3354, 3639, 3676, 3780, 3811, 4212], 'total': [2799, 3341, 4080, 4150, 4310], 'determined': [2804, 2930, 3039, 3053, 3600], 'below.': [2807], 'After': [2808, 3190, 3757], 'h': [2810, 3304, 3680, 3774, 3886], 'treatment,': [2812], 'constitutively': [2823], '13Lomri': [2883], 'Scholar).Inhibition': [2958], 'Proteasome': [2960], 'Activity—Lactacystin': [2961], 'specific': [2964, 3090, 3361, 3696, 3736, 3835, 3849], 'inhibitor': [2966], 'covalently': [2971], 'active-site': [2974], 'threonine': [2976], 'residue': [2977], 'certain': [2979], 'β-subunits': [2981], '(51Fenteany': [2982], 'Schreiber': [2984], '8545-8548Abstract': [2991], '(381)': [2999], 'whether': [3004, 4069, 4216, 4336], 'degraded': [3010], 'lactacystin': [3024], 'Calbiochem)': [3027], 'Western': [3041, 3484, 3608, 4096, 4208], 'blot': [3042, 3609, 4097, 4209], 'analysis': [3043, 3843, 4098, 4210, 4261], 'below.In': [3046], 'Vitro': [3047], 'Assay—Total': [3049], 'using': [3054, 3094, 3360, 3461, 3601, 3701, 3732, 4033, 4099], 'assay': [3056, 3076, 3196, 3605, 4147, 4172], 'kit': [3057, 3077], '(Upstate': [3058, 3645, 3898, 3905, 3910], 'Biotechnology,': [3059, 3646, 3665, 3899, 3906, 3911], 'Inc.': [3060], 'Euromedex,': [3062], 'Mundolsheim,': [3063], 'France)': [3064], 'designed': [3065], 'measure': [3067], 'phosphotransferase': [3069], 'all': [3072, 3650, 4019, 4106], 'kinases.': [3074, 3866], 'based': [3079], 'on': [3080, 3440, 3620], 'measurement': [3081], 'substrate': [3091, 3862, 3971, 4101], 'peptide': [3092], '(KVEKIGEGTYGVVYK)': [3093], 'transfer': [3096, 3446], 'γ-phosphate': [3099], '[5′-32P]ATP.': [3101], 'Proteins': [3102, 3151], 'μg)': [3104, 3614, 3726], 'diluted': [3106], 'reaction': [3108, 3937, 3982], 'buffer': [3109, 3492, 3800, 3938], '(100': [3110], 'mm': [3111, 3116, 3119, 3122, 3130, 3496, 3501, 3507, 3526, 3941, 3946, 3949, 3953], 'Tris-HCl': [3112, 3497], '(pH': [3113, 3498, 3943], '7.2),': [3114, 3499], '125': [3115], 'MgCl2,': [3117, 3950], '25': [3118, 3168, 3945], 'MnCl2,': [3120], '2': [3121, 3129, 3525], 'EGTA,': [3123], '250': [3124], 'μm': [3125, 3959], 'sodium': [3126], 'orthovanadate,': [3127], 'dithiothreitol)': [3131], '10': [3133, 3144, 3510, 3513, 3516, 3958], 'μl': [3134, 3156, 3169, 3761, 3805], 'manganese/ATP': [3136], 'mixture': [3137, 3209], '(1': [3138], 'mCi/100': [3139], 'μl)': [3140, 3921], 'incubated': [3142, 3258, 3677, 3748, 3771, 3956], 'min': [3145, 3192, 3589, 3977], 'at': [3146, 3161, 3220, 3583, 3590, 3655, 3750, 3775, 3784, 3887, 3978, 4126], '30': [3147, 3588, 3976, 3979], '°C': [3148, 3752, 3889], 'agitation.': [3150], 'precipitated': [3153], '20': [3155, 3760, 3948], '40%': [3158], 'trichloroacetic': [3159], 'room': [3162], 'temperature': [3163], '5': [3165, 3205], 'min,': [3166, 3790], 'final': [3172], 'solution': [3173], 'spotted': [3175], 'onto': [3176, 3447, 3629], 'phosphocellulose': [3177], 'P-81': [3178], 'paper': [3179], 'squares,': [3180], 'washed': [3183, 3323, 3795, 3932], 'five': [3184], 'times': [3185, 3797, 3934], '0.75%': [3187], 'phosphoric': [3188], 'acid.': [3189], '3': [3191, 3789], 'acetone,': [3194], 'squares': [3197], 'transferred': [3199, 3628], 'scintillation': [3202, 3208, 3214], 'vial': [3203], 'containing': [3204, 3939], 'ml': [3206], 'measured': [3211, 3713], 'counter.Transient': [3215], 'Transfection—All': [3216], 'plated': [3219], '2500': [3221], 'cells/cm2': [3222], 'day': [3224], 'before': [3225], 'transfection.': [3226], 'cotransfected': [3230], 'plasmid': [3233], '(2.5': [3234], 'μg/3-cm': [3235], 'dish)': [3236], 'pSV-β-galactosidase': [3238], 'vector': [3240, 3261, 3270], '(50': [3241, 3961], 'ng': [3242], 'β-galactosidase;': [3244], 'Promega)': [3245], '1%': [3252, 3503], 'serum.': [3255], 'Cells': [3256, 3321], 'empty': [3260], '(pcDNA3)': [3262], '70Z-Cbl,': [3266], 'G306E': [3269], 'Exgen': [3272], '(Euromedex)': [3273], 'according': [3274, 3333, 3450], "manufacturer's": [3277, 3336, 3453], 'directions.': [3278], 'Efficiency': [3279], 'determination': [3285], 'β-galactosidase': [3287], '(β-galactosidase': [3289], 'reporter': [3290], 'gene': [3291, 3476], 'assay;': [3292], 'Roche': [3293], 'Applied': [3294], 'Science).': [3295], 'number': [3297], 'β-galactosidase-positive': [3299], 'counted': [3302], 'post-transfection.Reverse': [3305], 'Transcription': [3306], '(RT)-PCR': [3307], 'Analysis—The': [3308], 'lyn,': [3311, 3367], 'fyn,': [3312, 3366], 'COLIA1': [3315], 'mRNAs': [3316], 'analyzed': [3318, 4032], 'RT-PCR.': [3320], 'phosphate-buffered': [3325], 'saline': [3326], 'lysed': [3328], 'Extract-All': [3330], 'reagent': [3331], '(Eurobio)': [3332], 'instructions.': [3337], 'Three': [3338], 'μg': [3339, 3734, 3965], 'cellular': [3342], 'RNA': [3343], 'each': [3345, 3475], 'sample': [3346], 'reverse-transcribed,': [3348], 'cDNA': [3351, 3439], 'samples': [3352], 'divided': [3355], 'amplified': [3357, 3438], 'PCR': [3359], 'primers': [3362, 3395], 'dehydrogenase': [3370], '(GAPDH).': [3371], 'primer': [3373], 'sequences': [3374], 'fyn': [3377, 4269], '5′-TTGGAGGTGTGAACTCTTCG-3′': [3379], '(sense)': [3380, 3390], '5′-TGCCTGGATAGAGTCAACTGG-3′': [3382], '(antisense),': [3383], 'those': [3385], 'lyn': [3387, 4267], '5′-CATCATCACCGAGTACATGGC-3′': [3389], '5′-TTCTTCCGCTCGATGTATGC-3′': [3392], '(antisense).': [3393], 'GAPDH': [3400], '(14Lemonnier': [3404], 'Southern': [3430], 'blotting': [3431], 'performed': [3433, 4173, 4213], 'running': [3435, 3807], 'aliquots': [3436, 3612, 3724], '1.2%': [3441], 'agarose': [3442], 'gel,': [3443], 'followed': [3444], 'nylon': [3448], 'membrane': [3449], 'protocol': [3454], '(Amersham': [3455, 3706], 'Biosciences).': [3456, 3635, 3707, 3917], 'Autoradiographic': [3457], 'quantified': [3460], 'scanner': [3463], 'densitometer': [3464], '(Transydine': [3465], 'General': [3466], 'Corp.,': [3467], 'Ann': [3468], 'Arbor,': [3469], 'MI),': [3470], 'signal': [3473], 'related': [3478], 'GAPDH.Immunoprecipitation': [3482], 'Blot': [3485], 'Analysis—Cell': [3486], 'extracted': [3489], 'lysis': [3491, 3799], 'consisting': [3493], '50': [3495, 3520, 3804, 3940], '150': [3500], 'NaCl,': [3502], 'Nonidet': [3504], 'P-40,': [3505], '1': [3506, 3679, 3773], 'phenylmethylsulfonyl': [3508], 'fluoride,': [3509], 'leupeptin,': [3512], 'aprotinin,': [3515], 'nm': [3517, 3521], 'calyculin': [3518], 'A,': [3519], 'microcystin': [3522], 'LR,': [3523], 'Na3VO4': [3527], '(45Lemonnier': [3528], 'Ghayor': [3530], 'Guicheux': [3532], '2004;': [3539, 3565], '279:': [3540, 3566], '259-264Abstract': [3541], '(113)': [3549], '46Haÿ': [3552], 'Fromigué': [3556], 'O.': [3557], 'Guénou': [3558], '1650-1658Abstract': [3567], '(45)': [3575], 'Lysates': [3578], 'clarified': [3580], 'centrifugation': [3582, 3783], '12,000': [3584], '×': [3585, 3786], 'g': [3586, 3787], '4': [3591, 3751, 3776, 3888], '°C,': [3592], 'content': [3595], 'supernatants': [3598], 'DC': [3603], '(Bio-Rad).': [3606], 'For': [3607], 'analysis,': [3610, 3722], 'equal': [3611, 3723], '(80': [3613], 'lysates': [3617, 3729], 'electrophoresed': [3619], '6–15%': [3621], 'SDS-polyacrylamide': [3622], 'gradient': [3623], 'gels.': [3624], 'Electrophoresed': [3625], 'polyvinylidene': [3630], 'difluoride': [3631], 'membranes': [3632, 3637, 3819], '(Hybond-P,': [3633], 'Amersham': [3634], 'reacted': [3640, 3821], 'either': [3642], 'anti-phospho-Src': [3643], 'antibody': [3644, 3661, 3672, 3737], 'Inc.),': [3647, 3692, 3900, 3907, 3912], 'recognizes': [3649], 'phosphorylated': [3654, 4104], 'Tyr416;': [3656], 'anti-Lyn': [3658, 3915], 'anti-Fyn': [3660], '(1:1000;': [3662], 'Santa': [3663, 3666, 3744], 'Cruz': [3664, 3745, 3766, 3973], 'Cruz,': [3667], 'CA);': [3668], 'anti-actin': [3671], '(1:200;': [3673], 'appropriate': [3683], 'affinity-purified': [3684], 'anti-rabbit': [3685], 'anti-mouse': [3687], 'IgG': [3688], '(Jackson': [3689], 'ImmunoResearch': [3690], 'Laboratories,': [3691], 'probed': [3693, 3832], 'peroxidase-coupled': [3695, 3834], 'secondary': [3697, 3836], 'antibodies,': [3698], 'visualized': [3700, 3839, 4002], 'enhanced': [3702, 3841], 'chemiluminescence': [3703], 'detection': [3704], 'kits': [3705], 'scanning': [3715], 'densitometry': [3716], 'corrected': [3718], 'actin.For': [3720], 'immunoprecipitation': [3721], '(300': [3725], 'immunoprecipitated': [3731, 3883], '2.5': [3733, 3964], '(anti-FGFR2,': [3738], 'anti-Cbl,': [3739, 3825], 'anti-Lyn,': [3740, 3823], 'anti-Fyn,': [3741, 3824, 3902], 'anti-ubiquitin;': [3743], 'Biotechnology)': [3746, 3767, 3974], 'overnight': [3749], 'rotating': [3755], 'device.': [3756], 'A/G-agarose': [3764], '(Santa': [3765, 3972], 'added': [3769, 3923], '°C.': [3777, 3980], 'Immunoprecipitates': [3778, 3930], 'collected': [3781], '1200': [3785], 'pellets': [3793], 'four': [3796, 4010], 'resuspended': [3802], 'buffer.': [3808], 'Aliquots': [3809], 'subjected': [3812], 'electrophoresis': [3814], 'above,': [3817], 'anti-ubiquitin,': [3826], 'anti-FGFR2': [3828], 'antibody.': [3829], 'Immunoblots': [3830], 'antibodies': [3837, 3893], 'chemiluminescence.For': [3842], 'members,': [3852], 'Sam68': [3856, 3867, 3967], 'protein,': [3857], 'functions': [3859], 'reflects': [3873], 'Equal': [3877], 'amounts': [3878], 'lysate': [3880], '18': [3885], 'following': [3892], '(2': [3894], 'μg/ml):': [3895], 'monoclonal': [3896, 3901], 'anti-Src60': [3897], 'polyclonal': [3903, 3908, 3914], 'anti-Yes': [3904], 'anti-Fgr': [3909], '(BD': [3916], 'Sepharose': [3918], 'beads': [3919], '(20–30': [3920], 'last': [3926], 'hour': [3927], 'incubation.': [3929], 'three': [3933], 'Tris': [3942], '7.4),': [3944], 'β-glycerophosphate,': [3947], '1.0': [3952], 'dithiothreitol': [3954], '[32P]ATP': [3960], 'μCi/ml)': [3962], '(p68)': [3968], 'stopped': [3984], '2×': [3988], 'buffer,': [3989], 'products': [3992], 'resolved': [3994], 'SDS-PAGE.': [3996], 'incorporation': [3998], '[32P]phosphate': [4000], 'autoradiography.Data': [4004], 'Analysis—Experiments': [4005], 'repeated': [4007], 'two': [4008], 'times,': [4011], 'results': [4014, 4022, 4282], 'presented': [4015], 'representative': [4017], 'experiments.': [4020], 'mean': [4027, 4046], '±': [4028], 'S.E.': [4029], 'statistical': [4035], 'package': [4036], 'super-ANOVA': [4037], '(Macintosh,': [4038], 'Abacus': [4039], 'Concepts,': [4040], 'Berkeley,': [4042], 'CA).': [4043], 'Differences': [4044], 'values': [4047], 'evaluated': [4049], 'minimal': [4052], 'significance': [4053], 'p': [4055], '<': [4056], '0.05.RESULTSThe': [4057], 'Overactive': [4058, 4333], 'Mutation': [4061], 'Reduces': [4062], 'Activity': [4065], 'Osteoblasts—To': [4067], 'assess': [4068], 'alters': [4079], 'assessed': [4087], 'state': [4090], 'members.': [4109, 4187], 'As': [4110, 4235], 'Fig.': [4113, 4238], '1A,': [4114], 'significant': [4118], 'decrease': [4119], 'corresponding': [4129], 'Try416': [4131], 'bearing': [4134], '(Fig.': [4143, 4165, 4206, 4279], '1A).': [4144], 'confirmed': [4148], '∼2-fold': [4157], '1B).': [4166], 'Consistently,': [4167], 'revealed': [4178], 'Notably,': [4188], 'markedly': [4197, 4248], '1C).': [4207], 'investigate': [4215], 'resulted': [4225], 'amount': [4229, 4241, 4265, 4292], 'proteins.': [4234], '1D,': [4239], 'cells.': [4257], 'contrast,': [4259], 'RT-PCR': [4260], 'transcripts': [4270], '1E).': [4280], 'contributes': [4306], 'osteoblasts.Both': [4316], 'Kinases': [4321], 'Overexpression': [4323], 'Reduce': [4328], 'Up-regulation': [4330], 'Induced': [4331], 'FGFR2—To': [4334], 'mutation,': [4355], 'examined': [4357], 'known': [4363], 'activator': [4364], 'ki': [4367]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2093339971', 'counts_by_year': [{'year': 2024, 'cited_by_count': 5}, {'year': 2022, 'cited_by_count': 5}, {'year': 2021, 'cited_by_count': 5}, {'year': 2020, 'cited_by_count': 4}, {'year': 2019, 'cited_by_count': 4}, {'year': 2018, 'cited_by_count': 4}, {'year': 2015, 'cited_by_count': 4}, {'year': 2014, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 6}, {'year': 2012, 'cited_by_count': 8}], 'updated_date': '2024-12-29T16:48:19.942427', 'created_date': '2016-06-24'}
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