Publication Information

{'id': 'https://openalex.org/W2093246497', 'doi': 'https://doi.org/10.1073/pnas.041611298', 'title': 'The structure of the ultraspiracle ligand-binding domain reveals a nuclear receptor locked in an inactive conformation', 'display_name': 'The structure of the ultraspiracle ligand-binding domain reveals a nuclear receptor locked in an inactive conformation', 'publication_year': 2001, 'publication_date': '2001-02-06', 'ids': {'openalex': 'https://openalex.org/W2093246497', 'doi': 'https://doi.org/10.1073/pnas.041611298', 'mag': '2093246497', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/11171988', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/29294'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1073/pnas.041611298', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S125754415', 'display_name': 'Proceedings of the National Academy of Sciences', 'issn_l': '0027-8424', 'issn': ['0027-8424', '1091-6490'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320052', 'host_organization_name': 'National Academy of Sciences', 'host_organization_lineage': ['https://openalex.org/P4310320052'], 'host_organization_lineage_names': ['National Academy of Sciences'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://europepmc.org/articles/pmc29294?pdf=render', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5090150169', 'display_name': 'Gina M. Clayton', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I170203145', 'display_name': 'MRC Laboratory of Molecular Biology', 'ror': 'https://ror.org/00tw3jy02', 'country_code': 'GB', 'type': 'facility', 'lineage': ['https://openalex.org/I170203145', 'https://openalex.org/I4210087105', 'https://openalex.org/I90344618']}, {'id': 'https://openalex.org/I90344618', 'display_name': 'Medical Research Council', 'ror': 'https://ror.org/03x94j517', 'country_code': 'GB', 'type': 'government', 'lineage': ['https://openalex.org/I4210087105', 'https://openalex.org/I90344618']}], 'countries': ['GB'], 'is_corresponding': True, 'raw_author_name': 'G. M. Clayton', 'raw_affiliation_strings': ['Medical Research Council Laboratory of Molecular Biology, Cambridge CB2 2QH, United Kingdom;'], 'affiliations': [{'raw_affiliation_string': 'Medical Research Council Laboratory of Molecular Biology, Cambridge CB2 2QH, United Kingdom;', 'institution_ids': ['https://openalex.org/I170203145', 'https://openalex.org/I90344618']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': ['https://openalex.org/A5090150169'], 'corresponding_institution_ids': ['https://openalex.org/I170203145', 'https://openalex.org/I90344618'], 'apc_list': None, 'apc_paid': None, 'fwci': 5.279, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 133, 'citation_normalized_percentile': {'value': 0.839142, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 97, 'max': 98}, 'biblio': {'volume': '98', 'issue': '4', 'first_page': '1549', 'last_page': '1554'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11559', 'display_name': 'Retinoids in leukemia and cellular processes', 'score': 0.9988, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11559', 'display_name': 'Retinoids in leukemia and cellular processes', 'score': 0.9988, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10423', 'display_name': 'Neurobiology and Insect Physiology Research', 'score': 0.9973, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10445', 'display_name': 'Antioxidant Activity and Oxidative Stress', 'score': 0.9954, 'subfield': {'id': 'https://openalex.org/subfields/2704', 'display_name': 'Biochemistry'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/retinoid-x-receptor', 'display_name': 'Retinoid X receptor', 'score': 0.90320736}, {'id': 'https://openalex.org/keywords/ecdysone-receptor', 'display_name': 'Ecdysone receptor', 'score': 0.8987893}], 'concepts': [{'id': 'https://openalex.org/C128821507', 'wikidata': 'https://www.wikidata.org/wiki/Q3454518', 'display_name': 'Retinoid X receptor', 'level': 5, 'score': 0.90320736}, {'id': 'https://openalex.org/C109130350', 'wikidata': 'https://www.wikidata.org/wiki/Q22325789', 'display_name': 'Ecdysone receptor', 'level': 5, 'score': 0.8987893}, {'id': 'https://openalex.org/C63932345', 'wikidata': 'https://www.wikidata.org/wiki/Q422500', 'display_name': 'Nuclear receptor', 'level': 4, 'score': 0.8759441}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.6700184}, {'id': 'https://openalex.org/C2781121885', 'wikidata': 'https://www.wikidata.org/wiki/Q425517', 'display_name': 'Retinoic acid', 'level': 3, 'score': 0.6480784}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.620988}, {'id': 'https://openalex.org/C116569031', 'wikidata': 'https://www.wikidata.org/wiki/Q899107', 'display_name': 'Ligand (biochemistry)', 'level': 3, 'score': 0.61215186}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.5529014}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.4067207}, {'id': 'https://openalex.org/C86339819', 'wikidata': 'https://www.wikidata.org/wiki/Q407384', 'display_name': 'Transcription factor', 'level': 3, 'score': 0.39023507}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.107821256}], 'mesh': [{'descriptor_ui': 'D004268', 'descriptor_name': 'DNA-Binding Proteins', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D011987', 'descriptor_name': 'Receptors, Steroid', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D014157', 'descriptor_name': 'Transcription Factors', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D000595', 'descriptor_name': 'Amino Acid Sequence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018360', 'descriptor_name': 'Crystallography, X-Ray', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004268', 'descriptor_name': 'DNA-Binding Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D004268', 'descriptor_name': 'DNA-Binding Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D029721', 'descriptor_name': 'Drosophila Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004331', 'descriptor_name': 'Drosophila melanogaster', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008024', 'descriptor_name': 'Ligands', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D050356', 'descriptor_name': 'Lipid Metabolism', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008958', 'descriptor_name': 'Models, Molecular', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008969', 'descriptor_name': 'Molecular Sequence Data', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017433', 'descriptor_name': 'Protein Structure, Secondary', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011987', 'descriptor_name': 'Receptors, Steroid', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D011987', 'descriptor_name': 'Receptors, Steroid', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017386', 'descriptor_name': 'Sequence Homology, Amino Acid', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014157', 'descriptor_name': 'Transcription Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014157', 'descriptor_name': 'Transcription Factors', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1073/pnas.041611298', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S125754415', 'display_name': 'Proceedings of the National Academy of Sciences', 'issn_l': '0027-8424', 'issn': ['0027-8424', '1091-6490'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320052', 'host_organization_name': 'National Academy of Sciences', 'host_organization_lineage': ['https://openalex.org/P4310320052'], 'host_organization_lineage_names': ['National Academy of Sciences'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc29294', 'pdf_url': 'https://europepmc.org/articles/pmc29294?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC29294', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/11171988', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc29294', 'pdf_url': 'https://europepmc.org/articles/pmc29294?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 38, 'referenced_works': ['https://openalex.org/W1501286679', 'https://openalex.org/W1966843280', 'https://openalex.org/W1967261461', 'https://openalex.org/W1969839676', 'https://openalex.org/W1980222251', 'https://openalex.org/W1981939829', 'https://openalex.org/W1995017064', 'https://openalex.org/W1996127793', 'https://openalex.org/W1999580573', 'https://openalex.org/W2000517171', 'https://openalex.org/W2003877984', 'https://openalex.org/W2004899821', 'https://openalex.org/W2013083986', 'https://openalex.org/W2013378362', 'https://openalex.org/W2016146562', 'https://openalex.org/W2034975889', 'https://openalex.org/W2040053707', 'https://openalex.org/W2042271211', 'https://openalex.org/W2042901562', 'https://openalex.org/W2059291229', 'https://openalex.org/W2078606549', 'https://openalex.org/W2082151361', 'https://openalex.org/W2083914903', 'https://openalex.org/W2100221195', 'https://openalex.org/W2101738855', 'https://openalex.org/W2109894071', 'https://openalex.org/W2111650618', 'https://openalex.org/W2113456624', 'https://openalex.org/W2117590286', 'https://openalex.org/W2123858984', 'https://openalex.org/W2129260844', 'https://openalex.org/W2134106936', 'https://openalex.org/W2136689007', 'https://openalex.org/W2152040532', 'https://openalex.org/W2152675122', 'https://openalex.org/W2156575042', 'https://openalex.org/W2172256092', 'https://openalex.org/W4248595930'], 'related_works': ['https://openalex.org/W4236233796', 'https://openalex.org/W2187932746', 'https://openalex.org/W2128349500', 'https://openalex.org/W2093246497', 'https://openalex.org/W2068791200', 'https://openalex.org/W2042271211', 'https://openalex.org/W2017687363', 'https://openalex.org/W2000517171', 'https://openalex.org/W1984899370', 'https://openalex.org/W1569378052'], 'abstract_inverted_index': {'Ultraspiracle': [0], '(USP)': [1], 'is': [2, 39, 69, 140, 150, 172], 'the': [3, 7, 43, 50, 53, 77, 85, 91, 96, 176], 'invertebrate': [4], 'homologue': [5], 'of': [6, 45, 52, 95], 'mammalian': [8, 117], 'retinoid': [9], 'X': [10], 'receptor': [11], '(RXR).': [12], 'RXR': [13, 38], 'plays': [14], 'a': [15, 30, 73, 104, 133, 143, 168], 'uniquely': [16], 'important': [17], 'role': [18], 'in': [19, 76, 109, 116, 123], 'differentiation,': [20], 'development,': [21], 'and': [22, 68, 111], 'homeostasis': [23], 'through': [24, 49], 'its': [25, 46], 'ability': [26], 'to': [27, 33, 41, 60, 71, 120, 174], 'serve': [28], 'as': [29, 84], 'heterodimeric': [31, 78], 'partner': [32, 47, 81], 'many': [34], 'other': [35, 158], 'nuclear': [36, 159], 'receptors.': [37, 160], 'able': [40], 'influence': [42], 'activity': [44], 'receptors': [48, 82], 'action': [51], 'ligand': [54, 67, 145, 178], '9-cis': [55], 'retinoic': [56], 'acid.': [57], 'In': [58], 'contrast': [59], 'RXR,': [61], 'USP': [62, 97, 122, 131], 'has': [63, 132, 164], 'no': [64], 'known': [65], 'high-affinity': [66], 'thought': [70], 'be': [72], 'silent': [74], 'component': [75], 'complex': [79], 'with': [80], 'such': [83], 'ecdysone': [86], 'receptor.': [87], 'Here': [88], 'we': [89], 'report': [90], '2.4-A': [92], 'crystal': [93], 'structure': [94, 101], 'ligand-binding': [98], 'domain.': [99], 'The': [100], 'shows': [102, 129], 'that': [103, 130, 138, 153], 'conserved': [105], 'sequence': [106], 'motif': [107], 'found': [108], 'dipteran': [110], 'lepidopteran': [112], 'USPs,': [113], 'but': [114], 'not': [115], 'RXRs,': [118], 'serves': [119], 'lock': [121], 'an': [124], 'inactive': [125], 'conformation.': [126], 'It': [127], 'also': [128], 'large': [134], 'hydrophobic': [135], 'cavity,': [136], 'implying': [137], 'there': [139], 'almost': [141], 'certainly': [142], 'natural': [144, 177], 'for': [146, 156, 179], 'USP.': [147, 180], 'This': [148], 'cavity': [149, 163], 'larger': [151], 'than': [152], 'seen': [154], 'previously': [155], 'most': [157], 'Intriguingly,': [161], 'this': [162], 'partial': [165], 'occupancy': [166], 'by': [167], 'bound': [169], 'lipid,': [170], 'which': [171], 'likely': [173], 'resemble': [175]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2093246497', 'counts_by_year': [{'year': 2023, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 3}, {'year': 2017, 'cited_by_count': 3}, {'year': 2015, 'cited_by_count': 3}, {'year': 2014, 'cited_by_count': 3}, {'year': 2013, 'cited_by_count': 6}, {'year': 2012, 'cited_by_count': 6}], 'updated_date': '2024-12-08T19:50:30.892069', 'created_date': '2016-06-24'}