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'macrophages': [48, 126], 'vitro,': [50], 'probably': [51], 'same': [54], 'We': [61], 'found': [63], 'that,': [64], 'macrophages,': [67], 'nitrogen-containing': [68, 182, 232], '(such': [70], 'as': [71, 195], 'alendronate,': [72], 'ibandronate,': [73], 'and': [74, 106, 118, 127, 161, 215], 'risedronate)': [75], 'post-translational': [77, 190], 'modification': [78], '(prenylation)': [79], 'proteins,': [81], 'including': [82], 'GTP-binding': [84], 'protein': [85, 97, 211, 224], 'Ras,': [86], 'with': [87], 'farnesyl': [88, 116, 148], 'or': [89, 150, 222], 'geranylgeranyl': [90, 119, 151], 'isoprenoid': [91], 'groups.': [92], 'Clodronate': [93], 'did': [94], 'prenylation.': [98], 'Mevastatin,': [99], 'an': [100], 'inhibitor': [101], '3-hydroxy-3-methylglutatyl': [103], '(HMG)-CoA': [104], 'reductase': [105], 'hence': [107], 'biosynthetic': [109], 'pathway': [110, 221], 'required': [111], 'production': [114], 'pyrophosphate': [117, 149], 'pyrophosphate,': [120, 152], 'caused': [122], 'murine': [128, 165], 'osteoclasts': [129, 214], 'vitro.': [131], 'Furthermore,': [132, 234], 'alendronate-induced': [133], 'apoptosis,': [134, 137], 'like': [135], 'mevastatin-induced': [136], 'could': [138, 169], 'be': [139, 170], 'suppressed': [140], 'cells': [143], 'addition': [146, 174], 'while': [153], 'effect': [155], 'alendronate': [157], 'on': [158], 'number': [160], 'calvariae': [166], 'vitro': [168], 'overcome': [171], 'mevalonic': [176], 'acid.': [177], 'These': [178], 'observations': [179], 'suggest': [180], 'bisphosphonate': [183], 'cause': [185], 'following': [187], 'inhibition': [188], 'prenylation': [191, 212], 'proteins': [193], 'such': [194], 'Ras.': [196], 'It': [197], 'is': [198], 'likely': [199], 'potent': [202], 'preventing': [210], 'enzymes': [217], 'mevalonate': [220], 'prenyl': [223], 'transferases': [225], 'bisphosphonates.': [233], 'data': [236], 'support': [237], 'view': [239], 'clodronate': [241], 'acts': [242], 'a': [244], 'different': [245], 'mechanism.': [246]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2093164779', 'counts_by_year': [{'year': 2024, 'cited_by_count': 15}, {'year': 2023, 'cited_by_count': 19}, {'year': 2022, 'cited_by_count': 26}, {'year': 2021, 'cited_by_count': 34}, {'year': 2020, 'cited_by_count': 29}, {'year': 2019, 'cited_by_count': 30}, {'year': 2018, 'cited_by_count': 40}, {'year': 2017, 'cited_by_count': 25}, {'year': 2016, 'cited_by_count': 36}, {'year': 2015, 'cited_by_count': 43}, {'year': 2014, 'cited_by_count': 43}, {'year': 2013, 'cited_by_count': 52}, {'year': 2012, 'cited_by_count': 50}], 'updated_date': '2025-01-10T04:24:19.205823', 'created_date': '2016-06-24'}