Title: MINOCYCLINE EXCRETION AND DISTRIBUTION IN RELATION TO RENAL FUNCTION IN MAN
Abstract: Clinical and Experimental Pharmacology and PhysiologyVolume 1, Issue 4 p. 299-308 MINOCYCLINE EXCRETION AND DISTRIBUTION IN RELATION TO RENAL FUNCTION IN MAN S. Carney, S. Carney Department of Medicine and Microbiology, Austin Hospital, HeidelbergSearch for more papers by this authorR. A. Butcher, R. A. Butcher Department of Medicine and Microbiology, Austin Hospital, HeidelbergSearch for more papers by this authorJ. K. Dawborn, J. K. Dawborn Department of Medicine and Microbiology, Austin Hospital, HeidelbergSearch for more papers by this authorG. Pattison, G. Pattison Department of Medicine, Repatriation General Hospital, Heidelberg West, Victoria, AustraliaSearch for more papers by this author S. Carney, S. Carney Department of Medicine and Microbiology, Austin Hospital, HeidelbergSearch for more papers by this authorR. A. Butcher, R. A. Butcher Department of Medicine and Microbiology, Austin Hospital, HeidelbergSearch for more papers by this authorJ. K. Dawborn, J. K. Dawborn Department of Medicine and Microbiology, Austin Hospital, HeidelbergSearch for more papers by this authorG. Pattison, G. Pattison Department of Medicine, Repatriation General Hospital, Heidelberg West, Victoria, AustraliaSearch for more papers by this author First published: August 1974 https://doi.org/10.1111/j.1440-1681.1974.tb00552.xCitations: 28 Dr J. K. Dawborn, Department of Medicine, Austin Hospital, Heidelberg, Victoria 3084, Australia. AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Abstract SUMMARY 1. The biological half-life of minocycline in serum has been studied in twenty-one patients and shown to have no relationship to renal function. There is very little excretion of minocycline by the kidney, and practically none is removed by dialysis. 2. In normal subjects, minocycline therapy is not accompanied by a significant rise in blood urea concentration or urinary urea excretion. However, high doses may produce a marked increase in urea excretion. 3. Of eight patients with impaired renal function who were treated with a normal therapeutic dose of minocycline (200 mg/day), one showed a significant increase in urea excretion and a rise in plasma urea concentration. Two patients with severe unstable renal failure required dialysis following therapy. 4. Minocycline is unlikely to accumulate in patients with renal failure due to its predominantly gastrointestinal excretion and is therefore safe to use. 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Citing Literature Volume1, Issue4August 1974Pages 299-308 ReferencesRelatedInformation
Publication Year: 1974
Publication Date: 1974-08-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 42
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