Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2092975253', 'doi': 'https://doi.org/10.1016/0167-4781(95)00029-g', 'title': 'Eukaryotic DNA topoisomerases I', 'display_name': 'Eukaryotic DNA topoisomerases I', 'publication_year': 1995, 'publication_date': '1995-05-01', 'ids': {'openalex': 'https://openalex.org/W2092975253', 'doi': 'https://doi.org/10.1016/0167-4781(95)00029-g', 'mag': '2092975253', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/7772596'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/0167-4781(95)00029-g', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4210212269', 'display_name': 'Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression', 'issn_l': '0167-4781', 'issn': ['0167-4781', '1879-2634'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5103528460', 'display_name': 'Malini Gupta', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210140884', 'display_name': 'National Cancer Institute', 'ror': 'https://ror.org/040gcmg81', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210140884']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Malini Gupta', 'raw_affiliation_strings': ['Laboratory of Molecular Pharmacology, National Cancer Institute, National Institute of Health, Bethesda, MD 20892-4255, USA.'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of Molecular Pharmacology, National Cancer Institute, National Institute of Health, Bethesda, MD 20892-4255, USA.', 'institution_ids': ['https://openalex.org/I4210140884']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5103755490', 'display_name': 'Akira Fujimori', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210140884', 'display_name': 'National Cancer Institute', 'ror': 'https://ror.org/040gcmg81', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210140884']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Akira Fujimori', 'raw_affiliation_strings': ['Laboratory of Molecular Pharmacology, Developmental Therapeutic Program, Division of Cancer Treatment, National Cancer Institute, National Institute of Health, Bethesda, MD 20892-4255, USA'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of Molecular Pharmacology, Developmental Therapeutic Program, Division of Cancer Treatment, National Cancer Institute, National Institute of Health, Bethesda, MD 20892-4255, USA', 'institution_ids': ['https://openalex.org/I4210140884']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5042114293', 'display_name': '\ufeffYves Pommier', 'orcid': 'https://orcid.org/0000-0002-3108-0758'}, 'institutions': [{'id': 'https://openalex.org/I4210140884', 'display_name': 'National Cancer Institute', 'ror': 'https://ror.org/040gcmg81', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210140884']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Yves Pommier', 'raw_affiliation_strings': ['Laboratory of Molecular Pharmacology, Developmental Therapeutic Program, Division of Cancer Treatment, National Cancer Institute, National Institute of Health, Bethesda, MD 20892-4255, USA'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of Molecular Pharmacology, Developmental Therapeutic Program, Division of Cancer Treatment, National Cancer Institute, National Institute of Health, Bethesda, MD 20892-4255, USA', 'institution_ids': ['https://openalex.org/I4210140884']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 3.409, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 304, 'citation_normalized_percentile': {'value': 0.854978, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '1262', 'issue': '1', 'first_page': '1', 'last_page': '14'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11845', 'display_name': 'DNA Topoisomerases: Structure, Function, and Inhibition', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11845', 'display_name': 'DNA Topoisomerases: Structure, Function, and Inhibition', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12356', 'display_name': 'Role of Quinones in Toxicology and Pharmacology', 'score': 0.9836, 'subfield': {'id': 'https://openalex.org/subfields/3005', 'display_name': 'Toxicology'}, 'field': {'id': 'https://openalex.org/fields/30', 'display_name': 'Pharmacology, Toxicology and Pharmaceutics'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T13188', 'display_name': 'Biochemical and Pharmacological Functions of Beta-Carboline Alkaloids', 'score': 0.974, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/phthalazine', 'display_name': 'Phthalazine', 'score': 0.9806445}, {'id': 'https://openalex.org/keywords/pharmacological-functions', 'display_name': 'Pharmacological Functions', 'score': 0.442618}], 'concepts': [{'id': 'https://openalex.org/C2777527159', 'wikidata': 'https://www.wikidata.org/wiki/Q6593919', 'display_name': 'Phthalazine', 'level': 2, 'score': 0.9806445}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.505682}, {'id': 'https://openalex.org/C2777015399', 'wikidata': 'https://www.wikidata.org/wiki/Q4775337', 'display_name': 'Antithrombotic', 'level': 2, 'score': 0.43619257}, {'id': 'https://openalex.org/C21951064', 'wikidata': 'https://www.wikidata.org/wiki/Q899212', 'display_name': 'Combinatorial chemistry', 'level': 1, 'score': 0.43545792}, {'id': 'https://openalex.org/C89429830', 'wikidata': 'https://www.wikidata.org/wiki/Q735710', 'display_name': 'Scaffold', 'level': 2, 'score': 0.432605}, {'id': 'https://openalex.org/C70721500', 'wikidata': 'https://www.wikidata.org/wiki/Q177005', 'display_name': 'Computational biology', 'level': 1, 'score': 0.3945055}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.3762325}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.1970669}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.16723713}, {'id': 'https://openalex.org/C178790620', 'wikidata': 'https://www.wikidata.org/wiki/Q11351', 'display_name': 'Organic chemistry', 'level': 1, 'score': 0.087198794}, {'id': 'https://openalex.org/C136229726', 'wikidata': 'https://www.wikidata.org/wiki/Q327092', 'display_name': 'Biomedical engineering', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C164705383', 'wikidata': 'https://www.wikidata.org/wiki/Q10379', 'display_name': 'Cardiology', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D004264', 'descriptor_name': 'DNA Topoisomerases, Type I', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000595', 'descriptor_name': 'Amino Acid Sequence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002166', 'descriptor_name': 'Camptothecin', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D002166', 'descriptor_name': 'Camptothecin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002384', 'descriptor_name': 'Catalysis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004264', 'descriptor_name': 'DNA Topoisomerases, Type I', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D004264', 'descriptor_name': 'DNA Topoisomerases, Type I', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D005057', 'descriptor_name': 'Eukaryotic Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005057', 'descriptor_name': 'Eukaryotic Cells', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': False}, {'descriptor_ui': 'D015971', 'descriptor_name': 'Gene Expression Regulation, Enzymologic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008969', 'descriptor_name': 'Molecular Sequence Data', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017386', 'descriptor_name': 'Sequence Homology, Amino Acid', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D059004', 'descriptor_name': 'Topoisomerase I Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/0167-4781(95)00029-g', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4210212269', 'display_name': 'Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression', 'issn_l': '0167-4781', 'issn': ['0167-4781', '1879-2634'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/7772596', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 153, 'referenced_works': ['https://openalex.org/W1480948940', 'https://openalex.org/W1481505132', 'https://openalex.org/W1482083885', 'https://openalex.org/W1489040991', 'https://openalex.org/W1495106561', 'https://openalex.org/W1496754597', 'https://openalex.org/W1500465676', 'https://openalex.org/W1502059603', 'https://openalex.org/W1508099272', 'https://openalex.org/W1508438346', 'https://openalex.org/W1519710278', 'https://openalex.org/W1523561547', 'https://openalex.org/W1531617647', 'https://openalex.org/W1536538430', 'https://openalex.org/W1537255582', 'https://openalex.org/W1539599852', 'https://openalex.org/W1541204074', 'https://openalex.org/W1542531535', 'https://openalex.org/W1548522009', 'https://openalex.org/W1554741867', 'https://openalex.org/W1558058463', 'https://openalex.org/W1558964207', 'https://openalex.org/W1561913337', 'https://openalex.org/W1567210923', 'https://openalex.org/W1569239054', 'https://openalex.org/W1581614904', 'https://openalex.org/W1582272319', 'https://openalex.org/W1584141721', 'https://openalex.org/W1586467890', 'https://openalex.org/W1587797958', 'https://openalex.org/W1593461257', 'https://openalex.org/W1594492199', 'https://openalex.org/W1595184397', 'https://openalex.org/W1600385513', 'https://openalex.org/W1602588670', 'https://openalex.org/W1603945993', 'https://openalex.org/W1604739675', 'https://openalex.org/W1608352093', 'https://openalex.org/W1632388334', 'https://openalex.org/W1636605543', 'https://openalex.org/W1704248043', 'https://openalex.org/W176011971', 'https://openalex.org/W1820632660', 'https://openalex.org/W1823160408', 'https://openalex.org/W1850727413', 'https://openalex.org/W1884743999', 'https://openalex.org/W1900905714', 'https://openalex.org/W1906542334', 'https://openalex.org/W1923310201', 'https://openalex.org/W192877506', 'https://openalex.org/W1951707121', 'https://openalex.org/W1965756007', 'https://openalex.org/W1966121423', 'https://openalex.org/W1966574288', 'https://openalex.org/W1966821729', 'https://openalex.org/W1969047823', 'https://openalex.org/W1969762229', 'https://openalex.org/W1971425374', 'https://openalex.org/W1972410555', 'https://openalex.org/W1972432430', 'https://openalex.org/W1978325887', 'https://openalex.org/W1979157941', 'https://openalex.org/W1979566739', 'https://openalex.org/W1982061874', 'https://openalex.org/W1984650355', 'https://openalex.org/W1985331518', 'https://openalex.org/W1986363474', 'https://openalex.org/W1988613599', 'https://openalex.org/W1991666948', 'https://openalex.org/W1993971869', 'https://openalex.org/W1994240050', 'https://openalex.org/W1994422429', 'https://openalex.org/W1997243437', 'https://openalex.org/W1998665991', 'https://openalex.org/W1999506028', 'https://openalex.org/W2004211331', 'https://openalex.org/W2010863615', 'https://openalex.org/W2014300705', 'https://openalex.org/W2014431638', 'https://openalex.org/W2016192576', 'https://openalex.org/W2018185888', 'https://openalex.org/W2018589873', 'https://openalex.org/W2024463580', 'https://openalex.org/W2027459076', 'https://openalex.org/W2028164285', 'https://openalex.org/W2030744847', 'https://openalex.org/W2030893594', 'https://openalex.org/W2032385103', 'https://openalex.org/W2032894521', 'https://openalex.org/W2033315821', 'https://openalex.org/W2034949074', 'https://openalex.org/W2036903769', 'https://openalex.org/W2037563824', 'https://openalex.org/W2043703023', 'https://openalex.org/W2047935288', 'https://openalex.org/W2050741262', 'https://openalex.org/W2051249021', 'https://openalex.org/W2051380566', 'https://openalex.org/W2054760667', 'https://openalex.org/W2055948417', 'https://openalex.org/W2056382700', 'https://openalex.org/W2057032781', 'https://openalex.org/W2057409012', 'https://openalex.org/W2057459384', 'https://openalex.org/W2057897402', 'https://openalex.org/W2068070916', 'https://openalex.org/W2068635324', 'https://openalex.org/W2069814011', 'https://openalex.org/W2070498380', 'https://openalex.org/W2072467449', 'https://openalex.org/W2072608590', 'https://openalex.org/W2073756790', 'https://openalex.org/W2074194645', 'https://openalex.org/W2076564663', 'https://openalex.org/W2077559325', 'https://openalex.org/W2078751203', 'https://openalex.org/W2081565077', 'https://openalex.org/W2083285371', 'https://openalex.org/W2087293298', 'https://openalex.org/W2089017680', 'https://openalex.org/W2090247166', 'https://openalex.org/W2095066016', 'https://openalex.org/W2097396148', 'https://openalex.org/W2099312069', 'https://openalex.org/W2102345056', 'https://openalex.org/W2104828336', 'https://openalex.org/W2109772984', 'https://openalex.org/W2110010650', 'https://openalex.org/W2110617206', 'https://openalex.org/W2118553080', 'https://openalex.org/W2122210452', 'https://openalex.org/W2130039633', 'https://openalex.org/W2139497421', 'https://openalex.org/W2152012032', 'https://openalex.org/W2152326762', 'https://openalex.org/W2153186588', 'https://openalex.org/W2154654003', 'https://openalex.org/W2160558176', 'https://openalex.org/W226502161', 'https://openalex.org/W2283538748', 'https://openalex.org/W2289449612', 'https://openalex.org/W2328369261', 'https://openalex.org/W2395356244', 'https://openalex.org/W2398551395', 'https://openalex.org/W2404444211', 'https://openalex.org/W2412592566', 'https://openalex.org/W2429529028', 'https://openalex.org/W338601501', 'https://openalex.org/W4233567369', 'https://openalex.org/W4242306912', 'https://openalex.org/W4249805947', 'https://openalex.org/W43816515', 'https://openalex.org/W89631206'], 'related_works': ['https://openalex.org/W4309349401', 'https://openalex.org/W4251053734', 'https://openalex.org/W2949764800', 'https://openalex.org/W2754063701', 'https://openalex.org/W2616170779', 'https://openalex.org/W2398974310', 'https://openalex.org/W2338620727', 'https://openalex.org/W2051333685', 'https://openalex.org/W2016138543', 'https://openalex.org/W2003028572'], 'abstract_inverted_index': {'Phthalazine,': [0], 'a': [1, 34, 57], 'structurally': [2], 'and': [3, 18, 51, 61, 71, 86], 'pharmacologically': [4], 'versatile': [5], 'nitrogen-containing': [6], 'heterocycle,': [7], 'has': [8], 'gained': [9], 'more': [10], 'attention': [11], 'from': [12], 'medicinal': [13], 'chemists': [14], 'in': [15, 42, 68, 95], 'the': [16, 79, 88], 'design': [17], 'synthesis': [19], 'of': [20, 59, 83, 90], 'novel': [21], 'drugs': [22, 38], 'owing': [23], 'to': [24], 'its': [25], 'pharmacological': [26, 40, 81], 'potential.': [27], 'In': [28], 'particular,': [29, 43], 'phthalazine': [30, 65, 84], 'scaffold': [31, 94], 'appeared': [32], 'as': [33, 66, 92], 'pharmacophoric': [35], 'feature': [36], 'numerous': [37], 'exhibiting': [39], 'activities,': [41], 'antidiabetic,': [44], 'anticancer,': [45], 'antihypertensive,': [46], 'antithrombotic,': [47], 'anti-inflammatory,': [48], 'analgesic,': [49], 'antidepressant': [50], 'antimicrobial': [52], 'activities.': [53], 'This': [54], 'review': [55], 'presents': [56], 'summary': [58], 'updated': [60], 'detailed': [62], 'information': [63], 'on': [64], 'illustrated': [67], 'both': [69], 'patented': [70], 'non-patented': [72], 'literature.': [73], 'The': [74], 'reported': [75], 'literature': [76], 'have': [77], 'described': [78], 'optimal': [80], 'characteristics': [82], 'derivatives': [85], 'highlighted': [87], 'applicability': [89], 'phthalazine,': [91], 'potent': [93], 'drug': [96], 'discovery.': [97]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2092975253', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 3}, {'year': 2018, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 4}, {'year': 2016, 'cited_by_count': 3}, {'year': 2015, 'cited_by_count': 7}, {'year': 2014, 'cited_by_count': 4}, {'year': 2013, 'cited_by_count': 10}, {'year': 2012, 'cited_by_count': 2}], 'updated_date': '2024-09-13T04:24:21.199192', 'created_date': '2016-06-24'}