Title: Selective heat precipitability of reduced human hemoglobins in alkaline urea
Abstract: Solutions of reduced hemoglobins from patients with either SS, SC, or CC hemoglobinopathies precipitated when heated for two minutes at 100°C at pH 9.20 in the presence of 3.64 M urea, while hemolysates of normal adult AA and newborns (FA hemoglobin) remained clear. In patients with hemoglobin C trait (AC) having 30% or more C hemoglobin, precipitation also occurred. The conditions of pH and urea concentration affording precipitation of hemoglobin S approximated those observed for hemoglobin C.
Publication Year: 1979
Publication Date: 1979-01-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
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