Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2092703933', 'doi': 'https://doi.org/10.1016/s0304-3835(79)80044-0', 'title': 'Comparative metabolism and dna binding of 7,12-dimethylbenz[a]anthracene and its weakly carcinogenic 5-fluoro analog', 'display_name': 'Comparative metabolism and dna binding of 7,12-dimethylbenz[a]anthracene and its weakly carcinogenic 5-fluoro analog', 'publication_year': 1979, 'publication_date': '1979-04-01', 'ids': {'openalex': 'https://openalex.org/W2092703933', 'doi': 'https://doi.org/10.1016/s0304-3835(79)80044-0', 'mag': '2092703933', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/108013'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/s0304-3835(79)80044-0', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S106234763', 'display_name': 'Cancer Letters', 'issn_l': '0304-3835', 'issn': ['0304-3835', '1872-7980'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5076749458', 'display_name': 'Florian Daniel', 'orcid': 'https://orcid.org/0000-0003-3004-8702'}, 'institutions': [{'id': 'https://openalex.org/I52357470', 'display_name': 'The Ohio State University', 'ror': 'https://ror.org/00rs6vg23', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I52357470']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'F. Bernard Daniel', 'raw_affiliation_strings': ['Department of Radiology and Pharmacology, College of Medicine, (U.S.A.)', 'Division of Medicinal Chemistry, College of Pharmacy, (U.S.A.)', 'The Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43210 (U.S.A.)'], 'affiliations': [{'raw_affiliation_string': 'The Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43210 (U.S.A.)', 'institution_ids': ['https://openalex.org/I52357470']}, {'raw_affiliation_string': 'Department of Radiology and Pharmacology, College of Medicine, (U.S.A.)', 'institution_ids': []}, {'raw_affiliation_string': 'Division of Medicinal Chemistry, College of Pharmacy, (U.S.A.)', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5090551583', 'display_name': 'Frederick D. Cazer', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I52357470', 'display_name': 'The Ohio State University', 'ror': 'https://ror.org/00rs6vg23', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I52357470']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Frederick D. Cazer', 'raw_affiliation_strings': ['Division of Medicinal Chemistry, College of Pharmacy, (U.S.A.)', 'The Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43210 (U.S.A.)'], 'affiliations': [{'raw_affiliation_string': 'The Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43210 (U.S.A.)', 'institution_ids': ['https://openalex.org/I52357470']}, {'raw_affiliation_string': 'Division of Medicinal Chemistry, College of Pharmacy, (U.S.A.)', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5015973137', 'display_name': 'Steven M. D’Ambrosio', 'orcid': None}, 'institutions': [], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': "Steven M. D'Ambrosio", 'raw_affiliation_strings': ['Department of Radiology and Pharmacology, College of Medicine, (U.S.A.)'], 'affiliations': [{'raw_affiliation_string': 'Department of Radiology and Pharmacology, College of Medicine, (U.S.A.)', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5085291816', 'display_name': 'Ronald W. Hart', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I52357470', 'display_name': 'The Ohio State University', 'ror': 'https://ror.org/00rs6vg23', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I52357470']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Ronald W. Hart', 'raw_affiliation_strings': ['Department of Radiology and Pharmacology, College of Medicine, (U.S.A.)', 'Division of Medicinal Chemistry, College of Pharmacy, (U.S.A.)', 'The Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43210 (U.S.A.)'], 'affiliations': [{'raw_affiliation_string': 'The Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43210 (U.S.A.)', 'institution_ids': ['https://openalex.org/I52357470']}, {'raw_affiliation_string': 'Department of Radiology and Pharmacology, College of Medicine, (U.S.A.)', 'institution_ids': []}, {'raw_affiliation_string': 'Division of Medicinal Chemistry, College of Pharmacy, (U.S.A.)', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5031044460', 'display_name': 'Won Ho Kim', 'orcid': 'https://orcid.org/0000-0002-5682-9972'}, 'institutions': [], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Won Ho Kim', 'raw_affiliation_strings': ['Division of Medicinal Chemistry, College of Pharmacy, (U.S.A.)'], 'affiliations': [{'raw_affiliation_string': 'Division of Medicinal Chemistry, College of Pharmacy, (U.S.A.)', 'institution_ids': []}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5026470922', 'display_name': 'Donald T. Witiak', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I52357470', 'display_name': 'The Ohio State University', 'ror': 'https://ror.org/00rs6vg23', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I52357470']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Donald T. Witiak', 'raw_affiliation_strings': ['Division of Medicinal Chemistry, College of Pharmacy, (U.S.A.)', 'The Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43210 (U.S.A.)'], 'affiliations': [{'raw_affiliation_string': 'The Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43210 (U.S.A.)', 'institution_ids': ['https://openalex.org/I52357470']}, {'raw_affiliation_string': 'Division of Medicinal Chemistry, College of Pharmacy, (U.S.A.)', 'institution_ids': []}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5026470922'], 'corresponding_institution_ids': ['https://openalex.org/I52357470'], 'apc_list': {'value': 4100, 'currency': 'USD', 'value_usd': 4100, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 2.09, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 18, 'citation_normalized_percentile': {'value': 0.723779, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 86, 'max': 87}, 'biblio': {'volume': '6', 'issue': '4-5', 'first_page': '263', 'last_page': '272'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10433', 'display_name': 'Genotoxicity and Carcinogenesis Mechanisms', 'score': 0.9985, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10433', 'display_name': 'Genotoxicity and Carcinogenesis Mechanisms', 'score': 0.9985, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10375', 'display_name': 'Drug Metabolism and Pharmacogenomics', 'score': 0.9767, 'subfield': {'id': 'https://openalex.org/subfields/3004', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/30', 'display_name': 'Pharmacology, Toxicology and Pharmaceutics'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10123', 'display_name': 'Molecular Mechanisms of DNA Damage Response', 'score': 0.9683, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/7,12-dimethylbenz[a]anthracene', 'display_name': '7,12-Dimethylbenz[a]anthracene', 'score': 0.9299003}, {'id': 'https://openalex.org/keywords/benzanthracene', 'display_name': 'Benzanthracene', 'score': 0.5729652}, {'id': 'https://openalex.org/keywords/dna-damage', 'display_name': 'DNA Damage', 'score': 0.464}], 'concepts': [{'id': 'https://openalex.org/C2778938436', 'wikidata': 'https://www.wikidata.org/wiki/Q5205596', 'display_name': 'DMBA', 'level': 4, 'score': 0.9913714}, {'id': 'https://openalex.org/C2776260934', 'wikidata': 'https://www.wikidata.org/wiki/Q187487', 'display_name': '7,12-Dimethylbenz[a]anthracene', 'level': 5, 'score': 0.9299003}, {'id': 'https://openalex.org/C114246631', 'wikidata': 'https://www.wikidata.org/wiki/Q187661', 'display_name': 'Carcinogen', 'level': 2, 'score': 0.90581155}, {'id': 'https://openalex.org/C2779563022', 'wikidata': 'https://www.wikidata.org/wiki/Q422152', 'display_name': 'Anthracene', 'level': 2, 'score': 0.7459798}, {'id': 'https://openalex.org/C2778575167', 'wikidata': 'https://www.wikidata.org/wiki/Q6573', 'display_name': 'Hamster', 'level': 2, 'score': 0.6902074}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.6881783}, {'id': 'https://openalex.org/C552990157', 'wikidata': 'https://www.wikidata.org/wiki/Q7430', 'display_name': 'DNA', 'level': 2, 'score': 0.60239327}, {'id': 'https://openalex.org/C87644729', 'wikidata': 'https://www.wikidata.org/wiki/Q547502', 'display_name': 'Microsome', 'level': 3, 'score': 0.5831894}, {'id': 'https://openalex.org/C2909149047', 'wikidata': 'https://www.wikidata.org/wiki/Q2442512', 'display_name': 'Benzanthracene', 'level': 3, 'score': 0.5729652}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.49326986}, {'id': 'https://openalex.org/C62231903', 'wikidata': 'https://www.wikidata.org/wiki/Q1057', 'display_name': 'Metabolism', 'level': 2, 'score': 0.45505247}, {'id': 'https://openalex.org/C71240020', 'wikidata': 'https://www.wikidata.org/wiki/Q186011', 'display_name': 'Stereochemistry', 'level': 1, 'score': 0.3665915}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.26291463}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.20130473}, {'id': 'https://openalex.org/C555283112', 'wikidata': 'https://www.wikidata.org/wiki/Q1637543', 'display_name': 'Carcinogenesis', 'level': 3, 'score': 0.17732814}, {'id': 'https://openalex.org/C178790620', 'wikidata': 'https://www.wikidata.org/wiki/Q11351', 'display_name': 'Organic chemistry', 'level': 1, 'score': 0.17249912}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.10359609}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D015127', 'descriptor_name': '9,10-Dimethyl-1,2-benzanthracene', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D001551', 'descriptor_name': 'Benz(a)Anthracenes', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D004247', 'descriptor_name': 'DNA', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D015127', 'descriptor_name': '9,10-Dimethyl-1,2-benzanthracene', 'qualifier_ui': 'Q000031', 'qualifier_name': 'analogs & derivatives', 'is_major_topic': False}, {'descriptor_ui': 'D015127', 'descriptor_name': '9,10-Dimethyl-1,2-benzanthracene', 'qualifier_ui': 'Q000633', 'qualifier_name': 'toxicity', 'is_major_topic': False}, {'descriptor_ui': 'D015127', 'descriptor_name': '9,10-Dimethyl-1,2-benzanthracene', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001551', 'descriptor_name': 'Benz(a)Anthracenes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001711', 'descriptor_name': 'Biotransformation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002478', 'descriptor_name': 'Cells, Cultured', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006224', 'descriptor_name': 'Cricetinae', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004247', 'descriptor_name': 'DNA', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004622', 'descriptor_name': 'Embryo, Mammalian', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D066298', 'descriptor_name': 'In Vitro Techniques', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008647', 'descriptor_name': 'Mesocricetus', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008862', 'descriptor_name': 'Microsomes, Liver', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008862', 'descriptor_name': 'Microsomes, Liver', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D009374', 'descriptor_name': 'Neoplasms, Experimental', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009374', 'descriptor_name': 'Neoplasms, Experimental', 'qualifier_ui': 'Q000139', 'qualifier_name': 'chemically induced', 'is_major_topic': False}, {'descriptor_ui': 'D051381', 'descriptor_name': 'Rats', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013329', 'descriptor_name': 'Structure-Activity Relationship', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/s0304-3835(79)80044-0', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S106234763', 'display_name': 'Cancer Letters', 'issn_l': '0304-3835', 'issn': ['0304-3835', '1872-7980'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/108013', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/6', 'score': 0.65, 'display_name': 'Clean water and sanitation'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 27, 'referenced_works': ['https://openalex.org/W1488430785', 'https://openalex.org/W1839667055', 'https://openalex.org/W1864171094', 'https://openalex.org/W1882520884', 'https://openalex.org/W1966193842', 'https://openalex.org/W1974845606', 'https://openalex.org/W1974995298', 'https://openalex.org/W1983691140', 'https://openalex.org/W1991005125', 'https://openalex.org/W1994752387', 'https://openalex.org/W2009065805', 'https://openalex.org/W2017711782', 'https://openalex.org/W2028231838', 'https://openalex.org/W2034189893', 'https://openalex.org/W2034581891', 'https://openalex.org/W2059405810', 'https://openalex.org/W2073595914', 'https://openalex.org/W2080205981', 'https://openalex.org/W2089239269', 'https://openalex.org/W2110057880', 'https://openalex.org/W2110809902', 'https://openalex.org/W2132905138', 'https://openalex.org/W2171759926', 'https://openalex.org/W2217987105', 'https://openalex.org/W2269942396', 'https://openalex.org/W2334164222', 'https://openalex.org/W4247746418'], 'related_works': ['https://openalex.org/W2333893563', 'https://openalex.org/W2319314799', 'https://openalex.org/W2246519231', 'https://openalex.org/W2144329149', 'https://openalex.org/W2092703933', 'https://openalex.org/W2088580937', 'https://openalex.org/W2022642204', 'https://openalex.org/W2018581657', 'https://openalex.org/W1985671333', 'https://openalex.org/W1502762946'], 'abstract_inverted_index': {'Cultured': [0], 'Syrian': [1], 'hamster': [2, 33], 'embryo': [3], 'cells': [4], 'readily': [5], 'convert': [6], 'both': [7], 'the': [8, 32, 63], 'carcinogenic': [9, 19], 'polycyclic': [10], 'aromatic': [11], 'hydrocarbon,': [12], '7,12-dimethylbenz[a]': [13], 'anthracene': [14, 22], '(DMBA),': [15], 'and': [16], 'its': [17], 'weakly': [18], 'analogue,': [20], '5-fluoro-7,12-dimethylbenz[a]': [21], '(5F-DMBA),': [23], 'to': [24, 31, 48, 60, 67], 'water': [25, 49], 'soluble': [26, 50], 'metabolites.': [27], 'DMBA,': [28, 61], 'however,': [29], 'binds': [30, 66], 'cell': [34], 'DNA': [35, 68], 'at': [36, 56], 'least': [37], '2.8–3.0': [38], 'times': [39, 70], 'more': [40, 71], 'extensively': [41], 'than': [42], '5F-DMBA.': [43], 'Likewise,': [44], '5F-DMBA': [45], 'is': [46], 'converted': [47], 'metabolites': [51], 'by': [52], 'liver': [53], 'microsomal': [54], 'preparations': [55], 'a': [57], 'rate': [58], 'equal': [59], 'but': [62], 'latter': [64], 'compound': [65], '2.6–3.2': [69], 'effectively.': [72]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2092703933', 'counts_by_year': [{'year': 2021, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 1}], 'updated_date': '2024-08-15T09:02:48.883808', 'created_date': '2016-06-24'}