T Cell Receptor Signaling: Beyond Complex Complexes

Name: Work Video:
Duration: 3 min 30 s
Yanping Huang; Ronald L. Wange
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4416, 4596, 4671, 4735, 4767, 4832, 4894, 4899, 5132, 5304, 5347, 5364], 'surface': [83], 'class': [87, 2901], 'II': [88, 2982], 'complex': [91, 1028, 1973, 2274, 2289, 2372, 2742, 2761, 3178, 4085, 4106], '(peptide-MHC)': [92], 'expressed': [93, 2908], 'an': [95, 202, 222, 455, 689, 931, 1271, 1292, 1763, 1798, 1993, 2166, 2712, 2725, 2738, 3198, 3430, 3690, 4020, 4824, 4849, 4996, 5072, 5356], 'antigen-presenting': [96, 1994, 2303], 'cell.': [97, 5352], 'This': [98, 1975, 3262, 4740], 'initiates': [100], 'series': [102, 3629], 'biochemical': [104], 'events': [105, 207, 258, 2174, 5261], 'that': [106, 208, 293, 305, 479, 563, 580, 705, 722, 873, 1457, 1464, 1533, 1564, 1861, 1983, 2021, 2169, 2184, 2521, 2844, 2923, 3242, 3541, 3558, 4072, 4148, 4290, 4569, 4580, 4765, 5048, 5146], 'can': [107, 1612, 1782, 2450, 3987, 4414, 4742, 4830, 4950], 'differentially': [108], 'signal': [109], 'naive': [111], 'to:': [114], '1)': [115, 1352, 1871, 3649], 'enter': [116, 139], 'into': [117, 140, 330, 515, 2516, 4737], 'pathway': [119, 1369, 2625, 2826, 3241, 4131, 4330, 4826], 'leading': [120, 4132, 4331], 'generation': [122], 'effector': [124, 136, 2643, 4578], 'onset': [129], 'rapid': [131], 'proliferation': [132, 2073], 'and': [133, 174, 192, 242, 282, 335, 369, 371, 512, 561, 591, 698, 715, 732, 809, 879, 1012, 1021, 1057, 1096, 1108, 1135, 1146, 1237, 1248, 1258, 1263, 1287, 1300, 1372, 1419, 1438, 1440, 1449, 1571, 1598, 1603, 1627, 1654, 1662, 1696, 1776, 1790, 1810, 1873, 1877, 1886, 2027, 2041, 2054, 2072, 2160, 2200, 2277, 2301, 2386, 2441, 2500, 2528, 2626, 2638, 2668, 2734, 2748, 2750, 2764, 2769, 2835, 2837, 2856, 2885, 2891, 2913, 2976, 3020, 3032, 3063, 3181, 3194, 3300, 3302, 3305, 3655, 3668, 3683, 3699, 3779, 3785, 3793, 3951, 3960, 4089, 4093, 4205, 4307, 4407, 4419, 4450, 4542, 4695, 4756, 4843, 4859, 4869, 4873, 4890, 4945, 4949, 4960, 4965, 5053, 5138, 5160, 5177, 5276, 5300, 5311], 'production': [134, 4447], 'cytokines;': [137], '2)': [138, 1355, 1880, 3675], 'state': [142, 618, 691], 'antigenic': [144], 'non-responsiveness': [145], 'known': [146, 1284, 2756, 2925, 3652, 4200], 'as': [147, 185, 569, 884, 957, 1071, 1149, 1154, 1171, 1285, 1291, 1546, 1969, 2039, 2049, 2096, 2510, 2757, 3167, 3201, 3265, 3429, 3653, 3772, 4201, 4466, 4533, 5073], 'anergy;': [148], 'or': [149, 177, 2099, 2107, 3992, 4100, 4142, 4834], '3)': [150, 1373, 1884, 3684], 'die': [151], 'apoptosis.': [153], 'type': [155], 'elicited': [158], 'depends': [159], 'multiple': [161, 480, 1428, 1530, 4517], 'factors': [162, 1386, 2037, 2647, 2680], 'including': [163, 1432, 2731, 2851, 4145, 4751, 5112], 'affinity': [165], 'interaction,': [168, 173], 'duration': [170], 'presence': [176], 'absence': [178, 2710, 3620], 'various': [180, 1019, 4424], 'costimulatory': [181, 195], 'signaling': [182, 206, 237, 319, 411, 470, 1023, 1134, 1164, 1421, 1430, 1630, 1687, 1840, 1889, 1947, 2173, 2624, 2842, 4130, 4585, 5260], 'inputs': [183], 'such': [184, 2038, 2048], 'those': [186], 'provided': [187], 'CD4': [190, 920, 928], 'coreceptor': [191], 'CD28': [194], 'receptor.': [196], 'In': [197, 679, 908, 1067, 1635, 2430, 2494, 2708, 4192, 4519], 'this': [198, 252, 607, 2196, 2288, 2371, 2431, 2495, 2547, 3172, 5366], 'review': [199], 'we': [200, 5301, 5325], 'provide': [201], 'overview': [203, 223], 'are': [209, 328, 381, 552, 612, 1136, 1312, 1534, 1555, 1565, 1864, 2181, 2504, 2627, 2665, 2849, 4286, 4411, 4546, 5326], 'associated': [210, 757, 917, 3763, 4527], 'first': [213, 492], 'these': [215, 257, 379, 954, 1229, 1543, 1626, 1657, 1780, 2180, 2664, 3287, 3536, 4398, 4557], 'outcomes:': [216], 'activation.': [219, 2284, 3446, 3646, 4297, 4461, 4837], 'To': [220], 'present': [221, 2268], 'sufficiently': [225], 'broad': [226], 'scope,': [227], 'depth': [229], 'discussion': [231], 'each': [233, 365], 'aspect': [234, 5125], 'TCR': [236, 263, 403, 410, 453, 474, 488, 504, 514, 602, 631, 634, 641, 683, 804, 819, 926, 1027, 1085, 1133, 1539, 1946, 2026, 2063, 2105, 2286, 2294, 2447, 2623, 2820, 3768, 3796, 4900, 5264], 'is': [238, 245, 264, 276, 461, 463, 495, 603, 686, 701, 717, 741, 755, 800, 886, 915, 988, 1456, 1459, 1465, 1742, 1795, 1817, 1976, 2014, 2022, 2065, 2165, 2197, 2223, 2226, 2266, 2281, 2290, 2671, 2698, 2716, 2880, 2895, 2906, 2924, 3024, 3086, 3164, 3246, 3284, 3290, 3293, 3382, 3461, 3476, 3540, 3658, 3678, 3687, 3761, 3979, 4061, 4081, 4124, 4137, 4154, 4336, 4381, 4430, 4455, 4463, 4514, 4526, 4570, 4725, 4760, 4839, 4844, 4854, 4939, 5065, 5106, 5129, 5143, 5170, 5339, 5342, 5367], 'necessity': [240], 'limited,': [241], 'reader': [244], 'referred': [246, 1169, 1967], 'reviews': [249], 'cited': [250], 'throughout': [251], 'text': [253], 'for': [254, 408, 960, 1157, 1314, 1549, 1682, 2061, 2067, 2195, 2214, 2629, 2767, 2827, 3084, 3274, 3444, 3463, 3478, 3637, 3916, 3973, 4156, 4999, 5118, 5175], 'consideration': [255], 'in': [259, 295, 366, 373, 452, 483, 558, 566, 615, 688, 863, 930, 1122, 1132, 1138, 1227, 1253, 1274, 1351, 1365, 1374, 1380, 1562, 1589, 1632, 1659, 1838, 1866, 1942, 1952, 1955, 2024, 2272, 2381, 2546, 2615, 2648, 2658, 2661, 2718, 2877, 2910, 2964, 3017, 3171, 3175, 3208, 3270, 3295, 3439, 3469, 3480, 3618, 3643, 3788, 3910, 3975, 4015, 4019, 4067, 4084, 4098, 4211, 4295, 4378, 4452, 4471, 4510, 4549, 4556, 4560, 4566, 4583, 4772, 4775, 4819, 4897, 4991, 5001, 5316, 5333], 'more': [260, 637, 1139], 'detail.': [261], 'composed': [265, 3688, 4940], 'six': [267], 'different': [268, 578, 2825, 4748], 'polypeptide': [269], 'chains.': [270], 'specificity': [272], 'ligand': [274], 'binding': [275, 750, 958, 1547, 2309, 2461, 2537, 2723, 3268, 5150, 5173], 'dictated': [277], 'clonotypic': [280], 'TCRα': [281], 'TCRβ': [283], 'chains,': [284, 326], 'which': [285, 327, 625, 754, 962, 1152, 1378, 1767, 1802, 1824, 1829, 1963, 2206, 2225, 2508, 3657, 3677, 3686, 3969, 4055, 4667, 4732, 4828, 5116, 5317], 'arise': [286], 'from': [287, 502, 606, 817, 1297, 1301, 1309, 3472, 4388, 5329], 'process': [289, 1944, 2168], 'genetic': [291, 3631, 5004, 5049], 'rearrangement': [292], 'results': [294, 929, 1379, 2380], 'millions': [296], 'variants.': [299], 'These': [300, 392, 1014, 1087, 1118, 3647, 4298, 4544], 'chains': [301, 946], 'form': [302, 565, 1957, 5133], 'heterodimer': [304], 'binds': [306, 963, 1645, 1803, 1825], 'directly': [307, 1614, 2973], 'peptide-MHC.': [309], 'Communication': [310], 'TCRαβ': [312], 'peptide-MHC': [315], 'intracellular': [318, 4453], 'machinery': [320], 'occurs': [321], 'via': [322, 726, 749, 856, 964, 993, 1074, 1362, 1609, 2307, 2458, 2535, 2701, 2771, 3372, 4115], 'TCR-associated': [324], 'CD3': [325, 356, 610, 945], 'arranged': [329], 'three': [331, 372, 1769], 'dimers:': [332], 'γϵ,': [333], 'δϵ,': [334], 'ζζ': [336], '(1Alarcon': [337], 'B.': [338, 413, 660, 767, 1179, 1486, 1704, 3313, 3327, 3800, 3806, 3881, 3883, 4919, 5030, 5089], 'Gil': [339], 'D.': [340, 2582, 3409, 3496, 3804, 3826, 3851, 4617], 'Delgado': [341], 'P.': [342, 3117, 3568], 'Schamel': [343], 'W.W.': [344], 'Immunol.': [345, 414, 430, 520, 670, 768, 822, 1180, 1192, 1208, 1323, 1393, 1487, 1503, 1705, 1721, 1748, 1849, 1894, 1910, 1928, 2002, 2080, 2241, 2255, 2485, 2568, 2810, 2936, 3003, 3042, 3154, 3353, 3388, 3599, 3709, 3816, 3869, 4478, 4496, 4686, 4906, 4926, 5017, 5037, 5096, 5183], 'Rev.': [346, 415, 521, 769, 823, 1181, 1193, 1209, 1488, 1504, 1706, 1722, 1749, 1895, 2001, 2079, 2242, 2256, 2809, 2937, 3004, 3043, 3389, 3998, 4479, 4497, 4907, 5018, 5184], '2003;': [347, 416, 431, 522, 649, 671, 770, 824, 1182, 1194, 1210, 1489, 1505, 1707, 1723, 1750, 1896, 2003, 2081, 2144, 2243, 2486, 2569, 2601, 2866, 2938, 2991, 3005, 3044, 3073, 3155, 3232, 3390, 3710, 3730, 3747, 3896, 4317, 4367, 4480, 4498, 4687, 4806, 4908, 5019, 5185, 5221], '191:': [348, 417, 523, 771, 825, 1183, 1195, 1211, 1490, 1506, 1708, 1724, 1751, 1897, 2244], '38-46Crossref': [349], 'PubMed': [350, 419, 439, 525, 545, 652, 674, 773, 792, 827, 847, 903, 982, 1042, 1185, 1197, 1213, 1327, 1344, 1397, 1414, 1492, 1508, 1710, 1726, 1753, 1853, 1899, 1914, 1932, 2006, 2084, 2147, 2246, 2260, 2344, 2364, 2425, 2489, 2572, 2609, 2814, 2869, 2941, 2994, 3008, 3047, 3076, 3134, 3158, 3235, 3341, 3362, 3393, 3418, 3505, 3527, 3581, 3603, 3718, 3733, 3755, 3820, 3845, 3873, 3904, 3943, 4005, 4046, 4187, 4235, 4256, 4280, 4320, 4352, 4370, 4483, 4501, 4626, 4648, 4690, 4716, 4791, 4809, 4911, 4930, 4980, 5022, 5041, 5100, 5188, 5206, 5224, 5241], 'Scopus': [351, 420, 440, 526, 546, 653, 675, 774, 793, 828, 848, 904, 983, 1043, 1186, 1198, 1214, 1328, 1398, 1493, 1509, 1711, 1727, 1754, 1854, 1900, 1915, 1933, 2007, 2085, 2148, 2247, 2261, 2345, 2365, 2426, 2490, 2573, 2610, 2815, 2870, 2942, 2995, 3009, 3048, 3077, 3135, 3159, 3236, 3342, 3363, 3394, 3419, 3506, 3528, 3582, 3604, 3719, 3734, 3756, 3821, 3846, 3874, 3905, 3944, 4006, 4047, 4188, 4236, 4257, 4281, 4321, 4353, 4371, 4484, 4502, 4627, 4649, 4691, 4717, 4792, 4810, 4912, 4931, 4981, 5023, 5042, 5101, 5189, 5207, 5225, 5242], '(112)': [352, 3237], 'Google': [353, 422, 442, 528, 548, 655, 677, 776, 795, 830, 850, 906, 985, 1045, 1188, 1200, 1216, 1224, 1330, 1345, 1400, 1415, 1495, 1511, 1519, 1579, 1713, 1729, 1737, 1756, 1856, 1902, 1917, 1935, 2009, 2087, 2150, 2249, 2263, 2347, 2367, 2428, 2492, 2575, 2612, 2693, 2817, 2872, 2944, 2997, 3011, 3050, 3079, 3137, 3161, 3238, 3344, 3365, 3396, 3421, 3508, 3530, 3584, 3606, 3721, 3736, 3758, 3823, 3848, 3876, 3907, 3946, 4008, 4049, 4190, 4238, 4259, 4283, 4323, 4355, 4373, 4486, 4504, 4629, 4651, 4693, 4719, 4794, 4812, 4914, 4933, 4983, 5025, 5044, 5103, 5191, 5209, 5227, 5244], 'Scholar).': [354, 443, 549, 678, 796, 851, 907, 986, 1066, 1117, 1225, 1346, 1416, 1520, 1580, 1738, 1757, 1857, 1936, 2010, 2088, 2151, 2264, 2368, 2429, 2493, 2613, 2694, 2818, 2873, 2945, 3012, 3051, 3080, 3162, 3239, 3366, 3422, 3531, 3607, 3759, 3908, 3947, 4009, 4050, 4191, 4284, 4324, 4374, 4505, 4652, 4720, 4813, 4934, 4984, 5045, 5104, 5245, 5285], 'Each': [355], 'chain': [357], 'contains': [358], 'motifs': [362, 380, 955], '(ITAMs);': [363], 'one': [364, 1667, 3285, 3791, 5322, 5337], 'γ,': [367], 'δ': [368], 'ϵ': [370], 'ζ.': [374], 'eponymous': [376], 'features': [377], 'pair': [383], 'tyrosine': [385, 465, 620, 623, 703, 711, 737, 814, 862, 995, 1001, 1531, 1560, 1584, 1772, 2051], 'residues': [386, 1480, 1532, 1561, 1585, 4399], 'separated': [387], '9–11': [389], 'amino': [390], 'acids.': [391], 'tyrosines': [393, 1009, 1544], 'become': [394, 948], 'rapidly': [395, 2227], 'phosphorylated': [396, 1535, 1642, 4847], 'Src-family': [399], 'Lck': [401, 451, 500, 511, 584, 685, 748, 853, 914, 936], 'following': [402, 640, 990, 1084, 1538, 2232, 4091], 'stimulation;': [404], 'required': [406, 1313, 2060, 2066, 2628, 2850, 3462, 4155], 'event': [407], 'initiating': [409, 2062], '(2Malissen': [412], '7-27Crossref': [418], '(49)': [421], 'Scholar,': [423, 529, 656, 777, 831, 1046, 1189, 1201, 1217, 1331, 1401, 1496, 1512, 1714, 1730, 1903, 1918, 2250, 2348, 2576, 2998, 3138, 3345, 3397, 3509, 3585, 3722, 3737, 3824, 3849, 3877, 4239, 4260, 4356, 4487, 4630, 4795, 4915, 5026, 5192, 5210, 5228], '3Pitcher': [424], 'L.A.': [425, 3401, 3488, 4609], 'van': [426], 'Oers': [427], 'N.S.': [428], 'Trends': [429, 3352, 3708], '24:': [432, 3711, 3843], '554-560Abstract': [433], 'Full': [434, 436, 540, 542, 842, 844, 977, 979, 1037, 1039, 2339, 2341, 2359, 2361, 2420, 2422, 2604, 2606, 3336, 3338, 3357, 3359, 3713, 3715, 3750, 3752, 3899, 3901, 4275, 4277, 4347, 4349, 4786, 4788, 5201, 5203], 'Text': [435, 437, 541, 543, 843, 845, 978, 980, 1038, 1040, 2340, 2342, 2360, 2362, 2421, 2423, 2605, 2607, 3337, 3339, 3358, 3360, 3714, 3716, 3751, 3753, 3900, 3902, 4276, 4278, 4348, 4350, 4787, 4789, 5202, 5204], 'PDF': [438, 544, 846, 981, 1041, 2343, 2363, 2424, 2608, 3340, 3361, 3717, 3754, 3903, 4279, 4351, 4790, 5205], '(155)': [441], 'Given': [444, 5353], 'primacy': [446], 'ITAM': [448, 464, 941, 991], 'phosphorylation': [449, 466, 621, 996, 1773, 2383, 4955], 'signaling,': [454, 1377, 2064, 2069], 'especially': [456], 'important': [457, 1272, 2178, 3199, 4577, 4997, 5124], 'question': [458], 'answer': [460], 'how': [462, 5354], 'maintained': [467, 614, 687], 'below': [468], 'threshold': [471], 'prior': [472, 632, 681], 'engagement.': [475], 'Current': [476], 'data': [477], 'suggest': [478], 'mechanisms': [481], 'act': [482, 1148, 2095, 2978], 'concert': [484], 'block': [486], 'spontaneous': [487], 'signaling.': [489, 1540], 'At': [490], 'level,': [493], 'there': [494, 799, 4123], 'physical': [497], 'sequestration': [498, 810], 'away': [501, 816], 'virtue': [506, 586, 1473], 'differential': [508], 'partitioning': [509, 2705], 'lipid': [516, 554, 597, 745, 760, 807, 1470, 1671, 2154, 2230, 2299, 2378, 2456, 2889, 3263, 3467, 3765, 3783, 4109], 'rafts': [517, 551, 761, 808, 1471, 2155, 2231, 2300, 2379, 2457, 2534, 2890, 3468, 4110], '(4Horejsi': [518, 820], 'V.': [519, 821], '148-164Crossref': [524, 826], '(126)': [527, 829], '5Cherukuri': [530, 832], 'A.': [531, 785, 833, 896, 1333, 1403, 2586, 2590, 2933, 3000, 3039, 3127, 3142, 3144, 3323, 3351, 3517, 3743, 4183, 4364, 4475, 4493, 4638, 4706, 4803, 4903, 5014, 5180, 5218], 'Dykstra': [532, 834], 'M.': [533, 662, 835, 2134, 2477, 2688, 2935, 3002, 3041, 3109, 3321, 3705, 3814, 3891, 3930, 3934, 4033, 4037, 4162, 4164, 4477, 4905, 5016, 5182], 'Pierce': [534, 836], 'S.K.': [535, 837], 'Immunity.': [536, 838, 973, 1033, 3746], '2001;': [537, 839, 1929, 3333, 4002], '14:': [538, 840, 1325, 1395, 1851, 1912, 4928, 5039, 5098], '657-660Abstract': [539, 841], '(197)': [547, 849], 'Lipid': [550], 'heterogeneous': [553], 'microdomains': [555], 'relatively': [556], 'enriched': [557, 2023], 'sphingomyelin,': [559], 'glycosphingo-lipids,': [560], 'cholesterol': [562], 'spontaneously': [564], 'membranes': [568], 'consequence': [571, 4535], 'biophysical': [574], 'properties': [575], 'lipids': [579], 'comprise': [581], 'membrane.': [583, 1677], '(by': [585], 'it': [588, 1458, 2766, 4759, 5341], 'being': [589, 2918], 'myristoylated': [590], 'palmitoylated)': [592], 'constitutively': [593, 756, 916, 1466, 2267, 3546, 3762], 'partitions': [594], 'rafts,': [598], 'whereas': [599], 'unstimulated': [601], 'largely': [604], 'excluded': [605], 'fraction.': [608], 'ITAMs': [611], 'also': [613, 1077, 1269, 1423, 1613, 1644, 1965, 2090, 2451, 2529, 2541, 2967, 3056, 3196, 3369, 4082, 4208, 4287, 4464, 4822, 5066, 5107], 'subcritical': [617], 'phosphatases,': [624], 'have': [626, 1124, 2650, 2845, 3545, 3612, 3633, 5253, 5296, 5302], 'ready': [627], 'access': [628, 639], 'stimulation': [635, 642, 2821, 4092, 4901], 'but': [636, 2953, 3184, 3200, 3210, 3475, 4063, 5059, 5336], 'limited': [638], '(6Mustelin': [643], 'T.': [644, 3403, 3490, 3832, 3879, 4176, 4611], 'Tasken': [645], 'K.': [646, 3111, 3887, 3928, 4031, 4216, 4245], 'Biochem.': [647], 'J.': [648, 786, 897, 1338, 1408, 1927, 2130, 2353, 2481, 2484, 2567, 2865, 2990, 3072, 3113, 3121, 3128, 3153, 3330, 3349, 3407, 3412, 3494, 3499, 3523, 3598, 3707, 3739, 3812, 3865, 4269, 4316, 4362, 4615, 4620, 4644, 4712, 4801, 4974, 5216, 5235], '371:': [650], '15-27Crossref': [651], '(238)': [654], '7Stefanova': [657], 'I.': [658, 3926, 4029], 'Hemmer': [659], 'Vergelli': [661], 'Martin': [663], 'R.': [664, 783, 894, 2122, 2321, 2402, 2471, 3828, 4228], 'Biddison': [665], 'W.E.': [666], 'Germain': [667], 'R.N.': [668], 'Nat.': [669, 2000, 2078, 3815, 3868, 3997], '4:': [672], '248-254Crossref': [673], '(379)': [676], 'addition,': [680, 909, 4193], 'engagement,': [684], 'inactive': [690, 2440], 'combined': [694], 'actions': [695], 'Csk': [697, 700, 725, 731, 740, 883], 'PEP.': [699], 'phosphorylates': [706, 1078, 2762, 3249], 'negative': [708, 812, 876, 1022, 2100], 'regulatory': [709, 813, 860, 877, 2752], 'C-terminal': [710, 861, 1582, 1813, 3701], 'residue': [712], 'Lck,': [714, 2852, 3058], 'PEP': [716], 'hematopoietically': [719], 'restricted': [720, 1080], 'phosphatase': [721, 872], 'associates': [723, 1606], 'SH3': [728, 1805, 2459], 'domain': [729, 1673, 2314, 3666, 3693, 3703], 'dephosphorylates': [733, 874], 'loop': [736, 1000, 3443], 'Lck.': [739], 'co-localized': [742], 'raft': [746, 1672, 2498, 3018, 3106], 'resident': [747], 'tyrosine-phosphorylated': [752, 2316], 'Cbp/PAG,': [753], '(8Lindquist': [762, 1174, 1481, 1699], 'J.A.': [763, 1175, 1482, 1700, 2562], 'Simeoni': [764, 1176, 1483, 1701], 'L.': [765, 1050, 1101, 1177, 1484, 1702, 3859, 4360, 4491, 4799, 5214, 5269], 'Schraven': [766, 1178, 1485, 1703, 3326], '165-182Crossref': [772, 1184, 1491, 1709], '(50)': [775, 1187, 1494, 1712], '9Hermiston': [778], 'M.L.': [779, 890, 2138, 2859, 2984, 3066, 3152, 4310], 'Xu': [780, 891, 4248], 'Z.': [781, 892], 'Majeti': [782, 893], 'Weiss': [784, 895, 3350], 'Clin.': [787, 898], 'Invest.': [788, 899], '2002;': [789, 900, 1324, 1341, 1394, 1411, 1850, 1911, 2257, 2336, 2417, 3131, 3354, 3415, 3502, 3524, 3600, 3817, 3870, 4184, 4232, 4253, 4344, 4623, 4645, 4713, 4783, 4927, 5038, 5097, 5198], '109:': [790, 901, 4345, 4784, 5199], '9-14Crossref': [791, 902], '(137)': [794, 905], 'Following': [797], 'stimulation,': [798, 2287, 3769], 'increased': [801, 866, 932, 4075, 4833, 5080, 5119], 'distribution': [802], 'phosphatases': [815, 2052, 3557], 'Concurrently': [852], 'becomes': [854], 'activated': [855, 989, 2374, 2524, 3294, 4842, 4952, 5108, 5358], 'dephosphorylation': [857, 4427], 'exposure': [867, 881], 'CD45,': [869], 'transmembrane': [871, 1461], 'site,': [878], 'decreased': [880], 'Cbp/PAG': [885], 'transiently': [887], 'dephosphorylated': [888], '(9Hermiston': [889], 'because': [910, 1307, 3092, 3551, 4551], 'portion': [912, 1814], 'coreceptor,': [921], 'peptide-MHC-induced': [923], 'co-localization': [924], 'local': [933], 'concentration': [934], 'around': [937], 'TCR.': [939], 'sequences': [942], 'subsequently': [947], 'fully': [949, 952], 'tyrosine-phosphorylated.': [950], 'Once': [951], 'phosphorylated,': [953, 1143, 1542, 1779], 'serve': [956, 1016, 1153, 1545], 'sites': [959, 1015, 1548, 1770, 1781, 2213, 5151], 'ZAP-70,': [961, 2853], 'tandem': [966], 'SH2': [967, 1551, 1785, 1822, 2313], 'domains': [968, 1526, 1786, 1806, 3698], '(10Wange': [969, 1029], 'R.L.': [970, 1030, 1048, 1099, 1219, 1514, 1574, 1732, 1926, 3387, 3574, 5267], 'Samelson': [971, 1031, 1206, 1501, 1719, 2239], 'L.E.': [972, 1032, 1207, 1502, 1720, 2240], '1996;': [974, 1034], '5:': [975, 1035], '197-205Abstract': [976, 1036], '(465)': [984, 1044], 'ZAP-70': [987, 1006, 1076, 1537, 2317], 'recruitment': [992, 2199, 2499, 2556, 2950, 3019, 3107, 3465, 3479], 'Lck-mediated': [994], '(Tyr-493)': [1002], 'ZAP-70.': [1004], 'Activated': [1005], 'autophosphorylates': [1007], 'at': [1008, 1985, 2156, 2269, 2376, 2550, 4516, 4547, 4857], '292,': [1010], '315,': [1011], '319.': [1013], 'recruit': [1018], 'positive': [1020, 2098, 3441], 'effectors': [1024], '11Wange': [1047], 'Schmitz': [1049, 1100, 3151, 5268], 'Bacher': [1051, 1102, 2860, 2985, 3067, 4311, 5270], 'S.': [1052, 1103, 2120, 2350, 2803, 2861, 2986, 3068, 3222, 3808, 3932, 4035, 4174, 4182, 4266, 4312, 5271], 'Mechanisms': [1053, 1104, 5272], 'Signal': [1055, 1106, 5274], 'Transduction': [1056, 1107, 5275], 'Inducible': [1058, 1109, 5277], 'Gene': [1059, 1110, 5278], 'Expression.': [1060, 1111, 5279], 'Research': [1061, 1112, 5280], 'Signpost,': [1062, 1113, 5281], 'Kerala,': [1063, 1114, 5282], 'India2004:': [1064, 1115, 5283], '21-51Google': [1065, 1116, 5284], 'addition': [1068, 1636], 'serving': [1070], 'scaffold': [1073, 3661], 'self-phosphorylation,': [1075], 'set': [1081], 'substrates': [1083, 1121], 'stimulation.': [1086, 2448], 'include': [1088, 4299], 'α-tubulin,': [1089], 'Sam-68,': [1090], 'Vav-1,': [1091, 1788], 'VHR,': [1092], 'Shc,': [1093], 'Gab2,': [1094], 'LAT,': [1095, 1740], 'SLP-76': [1097, 1147, 1420, 1605, 1611, 1741, 1761, 1816, 1863, 3180], '(11Wange': [1098, 5266], 'latter': [1119], 'two': [1120, 1477, 2744, 3537, 3696], 'particular': [1123, 2649], 'been': [1125, 1349, 1831, 1966, 2523, 2651, 2846, 3427, 4209, 4669, 5254, 5298], 'recognized': [1126, 4465], 'play': [1128, 1270, 1586, 1834, 2654, 4095, 4292, 4768, 5332], 'pivotal': [1130], 'role': [1131, 1273, 1837, 2545, 2657, 3204, 4097, 4294, 4470, 4579, 4771, 4816, 4998], 'considered': [1137], 'detail': [1140], 'below.': [1141], 'When': [1142, 1541, 1778], 'both': [1144, 1310, 2435, 3187, 4953, 5158], 'LAT': [1145, 1455, 1563, 1593, 1608, 1643, 1683], 'linker/adapter': [1150, 1230], 'proteins,': [1151, 1431, 3958], 'nucleation': [1155, 2212], 'points': [1156], 'construction': [1159], 'higher': [1161, 1622], 'order': [1162, 1623], 'multimolecular': [1163, 3177], 'complexes': [1165, 1422, 5134], '(Fig.': [1166], '1),': [1167], 'often': [1168, 3988], 'signalosome': [1173, 1299], '12Clements': [1190], 'J.L.': [1191, 1747, 1893, 2252, 2473], '211-219Crossref': [1196, 1752, 1898], '(17)': [1199, 1755, 1901], '13Fuller': [1202, 1497, 1715], 'C.L.': [1203, 1498, 1716, 2236], 'Braciale': [1204, 1499, 1717, 2237], 'V.L.': [1205, 1500, 1718, 2238, 3411, 3498, 4489, 4619], '220-236Crossref': [1212, 1507, 1725, 2245], '(60)': [1215, 1510, 1728, 2248], '14Wange': [1218, 1513, 1731], "Science's": [1220, 1515, 1575, 1733, 2689], 'STKE.': [1221, 1516, 1576, 1734, 2690], '2000;': [1222, 1517, 1577, 1735, 3578], '(http://stke.sciencemag.org/cgi/content/full/sigtrans;2000/63/RE1)PubMed': [1223, 1518, 1578, 1736], 'Acting': [1226], 'concert,': [1228], 'proteins': [1231, 1445, 1601, 1631, 1639, 2047, 2843, 3031, 3288, 3642, 3972, 4948], 'regulate': [1232, 3989, 4420], 'PLCγ1': [1236, 1353, 1597, 1872, 3085, 3103, 3163], 'subsequent': [1239, 3952, 4446], 'hydrolysis': [1240], 'phosphatidylinositol': [1242], '(PI)-4,5-P2': [1243], 'generate': [1245, 3260], 'diacylglycerol': [1246], '(DAG)': [1247], 'inositol-1,4,5-P3': [1249], '(IP3),': [1250], 'second': [1251], 'messengers': [1252], 'C': [1256], '(PKC)': [1257], 'Ras': [1259], '(via': [1261, 1266], 'DAG)': [1262], 'calcium': [1264, 4675], 'mobilization': [1265, 1876], 'IP3).': [1267], 'They': [1268], 'another': [1278, 1668, 3792, 4194], 'TCR-activated': [1279], 'protein-tyrosine': [1280], 'kinase,': [1281, 4197], 'Itk': [1282, 1289, 1347, 2540], '(also': [1283, 2755, 3651, 4199], 'Emt': [1286], 'Tsk).': [1288], 'serves': [1290, 2434, 3264], 'integrator': [1293], 'signals': [1295, 1308, 2106, 2110, 2183, 5117], 'arising': [1296], '3-kinase': [1303], '(PI3K;': [1304], 'see': [1305], 'below),': [1306, 1371], 'pathways': [1311, 5111], '(15Miller': [1317, 1387], 'A.T.': [1318, 1388], 'Berg': [1319, 1389], 'L.J.': [1320, 1390], 'Curr.': [1321, 1391, 1847, 1908, 2599, 3894, 4684, 4924, 5035, 5094], 'Opin.': [1322, 1392, 1848, 1909, 4685, 4925, 5036, 5095], '331-340Crossref': [1326, 1396], '(76)': [1329, 1399], '16Takesono': [1332, 1402], 'Finkelstein': [1334, 1404, 2591], 'L.D.': [1335, 1405, 2592, 4220], 'Schwartzberg': [1336, 1406, 2595, 3571], 'P.L.': [1337, 1407, 2596, 3572], 'Cell': [1339, 1409, 3129], 'Sci.': [1340, 1410, 4180], '115:': [1342, 1412], '3039-3048Crossref': [1343, 1413], 'has': [1348, 1522, 1830, 1948, 1964, 2091, 2522, 2914, 3426, 4207, 4668, 5361], 'implicated': [1350, 3428, 4210], 'activation,': [1354, 1695, 3299, 4666, 4867, 4882, 4889, 5003], 'regulation': [1356], 'TCR-stimulated': [1358, 2659, 4440, 4511], 'actin': [1359, 2190, 2215, 3036], 'cytoskeleton': [1360, 3037], 'reorganization': [1361, 2187, 3033], 'involvement': [1364], 'regulating': [1366], 'Vav-1/Cdc42/WASP': [1368], '(see': [1370, 2958], 'so-called': [1375], '"inside-out"': [1376], 'β1': [1383], 'integrin': [1384], 'adhesion': [1385, 2036], 'Lat': [1418], 'support': [1424], 'other': [1429, 1527, 1629, 2831], 'mitogen-activated': [1433, 1692], 'kinases': [1435, 4289, 4750], '(p38,': [1436], 'Jnk,': [1437, 4754], 'Erk)': [1439], 'molecular': [1442, 5259, 5294], 'weight': [1443], 'G': [1444, 3030], '(Ras,': [1446], 'Rac,': [1447], 'Rho,': [1448], 'Cdc42).': [1450], 'A': [1451, 1937, 2217, 2874, 3013, 3532, 5286], 'key': [1452, 1836, 2218, 2656, 2875, 4385, 4469], 'feature': [1453], 'adapter': [1462], 'targeted': [1467], 'palmitoylation': [1475], 'juxtamembrane': [1478], 'cysteine': [1479], 'It': [1521, 2089, 2970, 5142], 'no': [1523], 'interaction': [1525], 'than': [1528, 2830], 'specific': [1550], 'domain-containing': [1552, 3278], 'proteins.': [1553, 3279], 'There': [1554, 4285], 'total': [1557], '8': [1559], 'conserved': [1566], 'between': [1567, 1625, 3535], 'humans,': [1568], 'mice,': [1569], 'rats,': [1570], 'bovines': [1572], '(14Wange': [1573], '5': [1583], 'critical': [1587, 2544, 3014, 3635, 4457], 'roles': [1588, 3636], 'ability': [1591, 1868, 2093, 2640, 5131], 'bind': [1595, 1615, 1783, 5157], 'linker': [1600], 'Gads': [1602], 'Grb2.': [1604], 'Gads.': [1610], 'PLCγ1,': [1617, 2855, 3062, 4443], 'indicating': [1618], 'existence': [1620], 'interactions': [1624, 3994], 'possibly': [1628, 3174, 5078], 'signalosome.': [1634], 'already': [1640], 'mentioned,': [1641], 'Grap,': [1648], '3BP2,': [1649], 'Shb,': [1650], 'SOS,': [1651], 'c-Cbl,': [1652], 'Vav,': [1653], 'Itk,': [1655, 1809, 4540], 'localizing': [1656], 'molecules': [1658], 'close': [1660, 2517], 'proximity': [1661, 2518], 'defined': [1664], 'orientation': [1665], 'within': [1669], 'plasma': [1676, 2559, 3272], 'Jurkat': [1678, 1858, 3482, 3542, 3609, 4022, 4573, 4591, 4659], 'deficient': [1681], 'expression': [1684, 2617, 3097, 4422, 4967, 5120], 'exhibit': [1685], 'severe': [1686], 'defects': [1688], 'Ca2+': [1690, 1875, 4531], 'mobilization,': [1691], 'NFAT': [1697, 1878, 4335, 4379, 4394, 4413, 4429, 4460, 4472, 4512, 4665, 4722, 4734, 4774, 4820, 4836, 4878, 5057, 5137, 5149, 5159], 'Unlike': [1739, 3965], 'cytosolic': [1744, 4150], '(12Clements': [1746, 1892], 'structure': [1759, 1982, 4069], 'includes': [1762, 1768], 'acidic': [1764, 1793], 'N-terminal': [1765, 3691, 4850], 'region,': [1766, 1801], '(Tyr-113,': [1774], 'Tyr-128,': [1775], 'Tyr-145).': [1777], 'Nck,': [1789], 'Itk.': [1791], 'region': [1794, 2019, 2467], 'followed': [1796, 3694], 'extended': [1799], 'proline-rich': [1800, 2466], 'Gads,': [1808], 'PLCγ1.': [1811, 4543], 'comprised': [1818], 'single': [1821], 'domain,': [1823], 'primarily': [1826, 2699, 2909], 'ADAP,': [1828], 'reported': [1832], 'inside-out': [1839, 1888], 'integrins': [1842, 1891], '(17Griffiths': [1843], 'E.K.': [1844, 1905], 'Penninger': [1845, 1906], 'J.M.': [1846, 1907], '317-322Crossref': [1852, 1913], '(56)': [1855, 1916], 'lack': [1862], 'defective': [1865, 4014, 4553, 4664, 4672, 4696], 'their': [1867], 'activate:': [1870], 'consequently': [1874, 2296], 'activation;': [1879], 'Ras/Raf/Mek/Erk': [1882, 5114], 'pathway;': [1883], 'NFκB;': [1885], '4)': [1887], '17Griffiths': [1904], '18Herndon': [1919], 'T.M.': [1920], 'Shan': [1921], 'X.': [1922, 3562, 3838, 3867], 'Tsokos': [1923], 'G.C.': [1924], 'Wange': [1925, 3386, 3573], '166:': [1930], '5654-5664Crossref': [1931], '(62)': [1934, 2871, 2996, 3078, 4322], 'new': [1938, 2211], 'layer': [1939], 'complexity': [1941, 4127], 'come': [1949], 'light': [1951], 'recent': [1953, 4143], 'years': [1954, 5250], 'synapse': [1961, 2931, 4114], '(IS),': [1962], '(SMAC).': [1974], 'dynamic': [1978], 'yet': [1979, 3202, 4125, 5074], 'highly': [1980, 4841], 'ordered': [1981], 'forms': [1984], 'site': [1987, 2159, 3269, 5165, 5174], 'contact': [1991, 2158, 2305], '(19Huppa': [1996, 2074], 'J.B.': [1997, 2075], 'Davis': [1998, 2076], 'M.M.': [1999, 2077, 4679], '3:': [2004, 2082, 3818, 3871], '973-983Crossref': [2005, 2083], '(443)': [2008, 2086], 'mature': [2012], 'IS': [2013, 2164], 'characterized': [2015], 'central': [2018], '(c-SMAC)': [2020], 'clustered': [2025], 'PKCθ,': [2028], 'surrounded': [2029], 'peripheral': [2032], 'ring': [2033, 2044, 3256], '(pSMAC)': [2034], 'LFA-1': [2040], 'distal': [2043], '(dSMAC)': [2045], 'containing': [2046, 2743, 3663], 'CD148': [2053], 'CD45.': [2055], 'although': [2058, 3376], 'not': [2059, 2972, 3185, 3211, 5009, 5061, 5343], 'sustained': [2068, 4835], 'IL-2': [2070, 5154, 5168], 'production,': [2071], 'servo,': [2101], 'either': [2102], 'amplifying': [2103], 'weak': [2104], 'attenuating': [2108], 'strong': [2109], '(20Lee': [2111], 'K.H.': [2112], 'Dinner': [2113], 'A.R.': [2114], 'Tu': [2115], 'C.': [2116, 3810, 4172], 'Campi': [2117], 'G.': [2118, 3123, 3329, 3863, 4224, 4251], 'Raychaudhuri': [2119], 'Varma': [2121], 'Sims': [2123], 'T.N.': [2124], 'Burack': [2125], 'W.R.': [2126], 'Wu': [2127], 'H.': [2128, 3924, 4027, 4166], 'Wang': [2129, 3858], 'Kanagawa': [2131], 'O.': [2132, 2863, 2988, 3070, 3140, 3798, 4314], 'Markiewicz': [2133], 'Allen': [2135], 'P.M.': [2136], 'Dustin': [2137], 'Chakraborty': [2139], 'A.K.': [2140], 'Shaw': [2141], 'A.S.': [2142], 'Science.': [2143, 3729], '302:': [2145, 3731], '1218-1222Crossref': [2146], '(466)': [2149], 'Clustering': [2152], 'formation': [2161, 2209], 'active': [2167], 'requires': [2170, 3057, 3955, 4887], 'several': [2171, 4747], 'upstream': [2172, 2219, 3015, 3205, 3431, 3452], 'occur.': [2176], 'Most': [2177, 3626], 'lead': [2185, 4073, 4831], 'cytoskeleton.': [2191], 'proximal': [2193, 5148], 'catalyst': [2194], 'Arp2/3': [2204, 2222], 'complex,': [2205], 'catalyzes': [2207], 'polymerization.': [2216], 'regulator': [2220, 3432], 'WASP,': [2224], 'recruited': [2228, 2291, 2453], 'TCR/CD28': [2233, 2735], 'costimulation': [2234, 2736], '(13Fuller': [2235], '21Cannon': [2251], 'Burkhardt': [2253, 2482, 2597], 'J.K.': [2254, 2483, 2598], '186:': [2258], '90-99Crossref': [2259], '(81)': [2262], 'WASP': [2265, 2280, 2396, 2438, 2444, 2449, 2469, 2503, 2515, 2531], 'high': [2270, 3547, 4655], 'stoichiometry': [2271], 'WIP': [2276, 2385, 2433], 'CrkL.': [2278], 'WIP-bound': [2279], 'refractory': [2282], 'Upon': [2285, 3767], '(and': [2295], 'site)': [2306], 'CrkL': [2312], '(22Sasahara': [2318, 2399], 'Y.': [2319, 2400, 3115, 3511, 3570, 3830, 3853, 4168, 4249, 4632, 4700], 'Rachid': [2320, 2401], 'Byrne': [2322, 2403], 'M.J.': [2323, 2404, 2805, 3564, 3885], 'de': [2324, 2405], 'la': [2325, 2406], 'Fuente': [2326, 2407], 'M.A.': [2327, 2408], 'Abraham': [2328, 2409, 2474, 3124, 3520, 4641, 4709], 'R.T.': [2329, 2410, 2475, 3125, 3521, 4642, 4710], 'Ramesh': [2330, 2411], 'N.': [2331, 2352, 2412, 2588, 3146, 3315, 3405, 3492, 4218, 4613], 'Geha': [2332, 2413], 'R.S.': [2333, 2414], 'Mol.': [2334, 2415, 3229, 3575, 3839, 3999], 'Cell.': [2335, 2416, 3230, 3576, 3840, 4000, 4343, 4782, 5197], '10:': [2337, 2418], '1269-1281Abstract': [2338, 2419], '(220)': [2346, 2427], '23Gelkop': [2349], 'Isakov': [2351], 'Biol.': [2354, 2600, 3130, 3231, 3331, 3577, 3841, 3895, 4001, 4270, 4976, 5237], 'Chem.': [2355, 3332, 4271], '1999;': [2356, 2691], '274:': [2357], '21519-21527Abstract': [2358], '(37)': [2366], 'Co-localization': [2369], 'PKCθ': [2375, 2884, 2894, 2963, 3023, 3055, 3105, 3207, 3244, 3303, 3371, 3464, 4888, 4990, 5000, 5007, 5069], 'disruption': [2387], 'WIP-WASP': [2390], 'association,': [2391], 'thereby': [2392], 'facilitating': [2393], 'Cdc42': [2398, 2520], 'model,': [2432], 'keep': [2437], 'basally': [2439, 4840], 'facilitate': [2443], 'upon': [2446, 4848], 'be': [2452, 4743, 4951], 'domain-mediated': [2460], 'Nck': [2463], '(24Zeng': [2470], 'Cannon': [2472], 'Way': [2476], 'Billadeau': [2478, 3225, 3518, 4639, 4707], 'D.D.': [2479, 3226, 3519, 4640, 4708], 'Bubeck-Wardenberg': [2480], '171:': [2487], '1360-1368Crossref': [2488], '(135)': [2491], 'case,': [2496], 'coordinated': [2505], 'SLP-76,': [2507, 2854, 3061], 'functions': [2509], 'targeting': [2512, 2530, 3914], 'scaffold,': [2513], 'bringing': [2514], 'SLP-76-bound': [2526], 'Vav-1': [2527, 2555, 2857, 3375, 3379, 3425, 3436, 3451, 3460, 4462, 4509, 4525, 4584], 'SLP-76-Gads-mediated': [2536], 'Lat.': [2539], 'plays': [2542, 3197, 4582], 'process,': [2548], 'apparently': [2549], 'level': [2552], 'supporting': [2554], 'membrane': [2560, 3273], '(25Grasis': [2561], 'Browne': [2563], 'C.D.': [2564, 2566], 'Tsoukas': [2565], '170:': [2570, 3156], '3971-3976Crossref': [2571], '(59)': [2574], '26Labno': [2577], 'C.M.': [2578, 2580], 'Lewis': [2579], 'You': [2581, 3829, 3852], 'Leung': [2583], 'D.W.': [2584], 'Takesono': [2585], 'Kamberos': [2587], 'Seth': [2589], 'Rosen': [2593], 'M.K.': [2594], '13:': [2602, 3897], '1619-1624Abstract': [2603], '(111)': [2611], 'Changes': [2614], 'gene': [2616, 2662], 'represent': [2618], 'culmination': [2620], 'gain': [2634], 'full': [2635], 'proliferative': [2636], 'competence': [2637], 'produce': [2642], 'cytokines.': [2644], 'Three': [2645], 'transcription': [2646, 2679, 4937, 5140], 'found': [2652, 4083], 'changes': [2660, 4066], 'expression;': [2663], 'NFκB,': [2666, 2787, 4328], 'NFAT,': [2667, 4406, 4731], 'AP-1.': [2669, 5161], 'NFκB—NFκB': [2670], 'collective': [2673], 'name': [2674], 'given': [2675], 'dimeric': [2678], 'Rel': [2683], 'family': [2684, 3029, 4947], '(27Rothwarf': [2685], 'D.M.': [2686, 3726], 'Karin': [2687], '(http://stke.sciencemag.org/cgi/content/full/sigtrans;1999/5/RE1)PubMed': [2692], 'Activation': [2695], 'NFκB': [2697, 2715, 2794, 2878, 3213, 3311, 3645, 3953, 4017, 4059, 4135, 4213, 4296, 4881, 5139, 5176], 'controlled': [2700], 'nuclear': [2703, 2783, 4157, 4402], 'cytoplasmic': [2704], 'NFκB.': [2707], 'activating': [2713, 2828, 2965], 'signal,': [2714], 'retained': [2717], 'cytoplasm': [2720], 'tight': [2722], 'inhibitory': [2726], 'protein.': [2728, 4395], 'Numerous': [2729], 'stimuli': [2730, 2832], 'TNFα,': [2732], 'IL-1,': [2733], 'activate': [2737, 3310, 4895, 5348], '(IKK)': [2741], 'subunits,': [2746], 'IKKα': [2747], 'IKKβ,': [2749], 'subunit,': [2753], 'IKKγ': [2754, 3915, 3949, 4012, 4056], 'NEMO).': [2758], 'IKK': [2760, 2829, 2966, 2975, 3780, 4071, 4076, 4105], 'targets': [2765, 3971], 'ubiquitination': [2768, 3919, 3950, 3986, 4057], 'proteolysis': [2770], '26': [2773], 'S': [2774], 'proteasome': [2775, 3977], 'complex.': [2776], 'degradation': [2778, 3974], 'unmasks': [2781], 'localization': [2784, 3053, 4403], 'sequence': [2785, 4404], 'allowing': [2788], 'translocation': [2789, 2887], 'nucleus,': [2792], 'where': [2793], 'regulates': [2795], 'activity': [2797, 4077, 4513], 'target': [2800, 2961], 'genes': [2801], '(28Ghosh': [2802], 'May': [2804], 'Kopp': [2806], 'E.B.': [2807], 'Annu.': [2808], '1998;': [2811, 4977, 5238], '16:': [2812], '225-260Crossref': [2813], '(4657)': [2816], 'Remarkably,': [2819], 'uses': [2822], 'completely': [2824], '(e.g.': [2833], 'TNFα': [2834], 'IL-1),': [2836], 'many': [2838, 5288], 'early': [2841], 'described': [2847], 'above': [2848], '(29Schmitz': [2858, 2983, 3065, 4309], 'Dienz': [2862, 2987, 3069, 4313], 'FASEB': [2864, 2989, 3071, 4315], '17:': [2867, 2992, 3074, 4318, 4368, 4807, 5222], '2187-2193Crossref': [2868, 2993, 3075, 4319], 'step': [2876, 4377], 'IS.': [2893], 'member': [2897], '"novel"': [2900], '(DAG-responsive,': [2902], 'Ca2+-independent)': [2903], 'PKCs,': [2905], 'selectively': [2907], 'cells,': [2912, 4522, 4575], 'distinction': [2916], 'only': [2920], 'PKC': [2921, 3189], 'isozyme': [2922], 'translocate': [2927, 4415], '(30Altman': [2932, 3038, 4474, 4902, 5013, 5179], 'Villalba': [2934, 3001, 3040, 4476, 4904, 5015, 5181], '192:': [2939, 3006, 3045, 3391, 4481, 4499, 4909, 5020, 5186], '53-63Crossref': [2940, 3007, 3046, 4482, 4910, 5021, 5187], '(99)': [2943, 3010, 3049, 4485, 4913, 5024, 5190], 'mechanism': [2947, 4053], 'raft/IS': [2949], 'remains': [2951, 2968], 'undetermined': [2952], 'appears': [2954, 4766], 'involve': [2956], 'CARMA-1': [2957, 3064, 3650, 3760, 3770], 'below).': [2959], 'unknown.': [2969], 'does': [2971, 5008, 5060], 'phosphorylate': [2974], 'may': [2977, 3368, 3437, 3455, 4094, 4586], 'through': [2979, 5071], 'calmodulin-dependent': [2980, 4300], '30Altman': [2999], 'element': [3016], 'Vav-1-mediated': [3025, 3622], 'Rho': [3028], 'Raft': [3052], 'PDK1,': [3060], 'Notably,': [3081], 'requirement': [3083], 'independent': [3087], 'enzymatic': [3090], 'activity,': [3091], 'neither': [3093], 'pharmacological': [3094], 'inhibition': [3095], 'nor': [3096], 'dominant-negative': [3100], 'allele': [3101], 'inhibits': [3104], '(31Villalba': [3108], 'Bi': [3110], 'Hu': [3112], 'Altman': [3114, 3126, 3516, 4637, 4705], 'Bushway': [3116], 'Reits': [3118], 'E.': [3119, 3593], 'Neefjes': [3120], 'Baier': [3122, 3328], '157:': [3132], '253-263Crossref': [3133], '(121)': [3136], '32Dienz': [3139], 'Moller': [3141], 'Strecker': [3143], 'Stephan': [3145], 'Krammer': [3147], 'P.H.': [3148], 'Droge': [3149], 'W.': [3150, 3889, 3936, 4039], '365-372Crossref': [3157], '(33)': [3160], 'likely': [3165], 'acting': [3166, 5070], 'scaffolding': [3169], 'pathway,': [3173, 5077, 5115], 'Vav-1.': [3182], 'PKCα': [3183], 'PKCβ,': [3186], '"conventional"': [3188], 'isotypes': [3190], '(responsive': [3191], 'DAG': [3193], 'Ca2+),': [3195], 'undefined': [3203, 5075], 'TCR/CD28-costimulated': [3209, 3644, 4134, 4212], 'TNFα-stimulated': [3212], '(33Trushin': [3215], 'S.A.': [3216], 'Pennington': [3217], 'K.N.': [3218], 'Carmona': [3219], 'E.M.': [3220, 3513, 4634, 4702], 'Asin': [3221], 'Savoy': [3223], 'D.N.': [3224], 'Paya': [3227], 'C.V.': [3228], '23:': [3233, 3355], '7068-7081Crossref': [3234], 'Another': [3240], 'affects': [3243], 'PI3K.': [3247, 3625], 'PI3K': [3248, 3298, 3445, 3454, 4554, 4581, 4829, 4863], 'D3': [3251], 'position': [3252], 'inositol': [3255], 'PI-4,5-P2': [3258], 'PI-3,4,5-P3.': [3261], 'selective': [3267], 'certain': [3275], 'pleckstrin': [3276], 'homology': [3277], 'serine/threonine': [3281, 3681, 4196, 4749, 4763], 'Akt': [3283, 3292, 3301, 4853, 4866], '(as': [3289, 3978], 'Itk).': [3291], 'physically': [3304], 'functionally': [3306], 'interact': [3307, 5320], 'synergistically': [3309], '(34Bauer': [3312], 'Krumbock': [3314], 'Fresser': [3316], 'F.': [3317, 3319, 3325], 'Hochholdinger': [3318], 'Spitaler': [3320], 'Simm': [3322], 'Uberall': [3324], '276:': [3334], '31627-31634Abstract': [3335], '(69)': [3343], '35Kane': [3346], 'L.P.': [3347], 'Lin': [3348, 3833, 3837, 3866], '413-420Abstract': [3356], '(161)': [3364], 'PI-3,4,5-P3': [3367, 3381, 3560, 3617, 4567], 'affect': [3370, 5062], 'controversial': [3383], '(36Seminario': [3384], 'M.C.': [3385], '80-97Crossref': [3392], '(43)': [3395], '37Reynolds': [3398], 'L.F.': [3399, 3486, 4495, 4607], 'Smyth': [3400, 3487, 4608], 'Norton': [3402, 3489, 4610], 'Freshney': [3404, 3491, 4612], 'Downward': [3406, 3493, 4614], 'Kioussis': [3408, 3495, 4616], 'Tybulewicz': [3410, 3497, 4618], 'Exp.': [3413, 3500, 4621], 'Med.': [3414, 3501, 4622], '195:': [3416, 3503, 4624], '1103-1114Crossref': [3417, 3504, 4625], '(180)': [3420, 3507, 4628], 'More': [3423], 'recently,': [3424], 'so': [3435], 'function': [3438, 3991, 5128], 'feedback': [3442], 'Interestingly,': [3447], 'placement': [3449], 'help': [3456], 'explain': [3458, 4587], 'why': [3459, 4588], 'Vav–/–': [3473], 'mice': [3474, 4892], 'dispensable': [3477], 'Vav-negative': [3481], '(37Reynolds': [3485, 4606], '38Cao': [3510, 4631], 'Janssen': [3512, 4633, 4701], 'Duncan': [3514, 3740, 4635, 4703], 'A.W.': [3515, 4636, 4704], 'EMBO': [3522, 4643, 4711], '21:': [3525, 4646, 4714], '4809-4819Crossref': [3526, 4647, 4715], '(88)': [3529, 4650, 4718], 'notable': [3533, 5145], 'difference': [3534], 'model': [3538], 'systems': [3539], 'levels': [3548, 3615, 5081], 'PI-3,4,5-P3,': [3550, 4657], 'they': [3552], 'fail': [3553, 4893], 'express': [3555], 'catabolize': [3559], '(39Shan': [3561], 'Czar': [3563], 'Bunnell': [3565], 'S.C.': [3566], 'Liu': [3567, 3569], '20:': [3579], '6945-6957Crossref': [3580], '(280)': [3583], '40Freeburn': [3586], 'R.W.': [3587], 'Wright': [3588], 'K.L.': [3589], 'Burgess': [3590], 'S.J.': [3591], 'Astoul': [3592], 'Cantrell': [3594], 'D.A.': [3595], 'Ward': [3596], 'S.G.': [3597], '169:': [3601], '5441-5450Crossref': [3602], '(100)': [3605], 'Thus': [3608], 'substantial': [3613], 'resting': [3614, 5350], 'recently': [3627], 'studies': [3632], 'established': [3634], 'number': [3639, 4141], 'novel': [3641], 'include:': [3648], 'CARD11': [3654], 'Bimp3),': [3656], 'lymphocyte-specific': [3660], 'molecule': [3662], 'caspase-recruitment': [3665], '(CARD)': [3667], 'membrane-associated': [3670], 'guanylate': [3671], 'kinase-like': [3672], '(MAGUK)': [3673], 'domain;': [3674], 'Bcl10,': [3676, 3777, 3909], 'CARD-containing': [3680, 4195], 'kinase;': [3682], 'MALT1/paracaspase,': [3685, 3959], 'death': [3692], 'immunoglobulin-like': [3697], 'caspase-like': [3702], '(41Thome': [3704], 'Tschopp': [3706, 3811], '419-424Abstract': [3712], '(86)': [3720], '42Ruefli-Brasse': [3723], 'A.A.': [3724, 4262], 'French': [3725], 'Dixit': [3727, 3937, 4040, 4267], 'V.M.': [3728, 3938, 4041, 4268], '1581-1584Crossref': [3732], '(308)': [3735], '43Ruland': [3738], 'G.S.': [3741], 'Wakeham': [3742], 'Mak': [3744], 'T.W.': [3745], '19:': [3748], '749-758Abstract': [3749], '(309)': [3757], 'rafts.': [3766], 'acts': [3771, 3912], 'scaffold/adaptor': [3774], 'recruiting': [3776, 4099], 'PKC-θ,': [3778], 'rafts/IS': [3784], 'placing': [3786], 'them': [3787], 'juxtaposition': [3789], '(44Gaide': [3797], 'Favier': [3799, 3882], 'Legler': [3801], 'D.F.': [3802], 'Bonnet': [3803], 'Brissoni': [3805], 'Valitutti': [3807], 'Bron': [3809], 'Thome': [3813, 3890], '836-843Crossref': [3819], '(293)': [3822], '45Wang': [3825], 'Matsumoto': [3827], 'Che': [3831], 'X.Y.': [3834], 'Gaffen': [3835], 'S.L.': [3836], '2004;': [3842, 3940, 4043, 4272], '164-171Crossref': [3844], '(183)': [3847], '46Wang': [3850], 'Case': [3854], 'S.M.': [3855], 'McAllister-Lucas': [3856], 'L.M.': [3857], 'DiStefano': [3860], 'P.S.': [3861], 'Nunez': [3862, 4223], 'Bertin': [3864], '830-835Crossref': [3872], '(256)': [3875], '47Egawa': [3878], 'Albrecht': [3880, 4918, 5029, 5088], 'Sunshine': [3884], 'Mirchandani': [3886], "O'Brien": [3888], 'Littman': [3892, 4922, 5033, 5092], 'D.R.': [3893, 4923, 4973, 5034, 5093, 5234], '1252-1258Abstract': [3898], '(216)': [3906], 'turn,': [3911], 'lysine': [3917, 3921, 3966, 3984], '63-linked': [3918, 3985], '399': [3922], '(48Zhou': [3923, 4026], 'Wertz': [3925, 4028], "O'Rourke": [3927, 4030], 'Ultsch': [3929, 4032], 'Seshagiri': [3931, 4034], 'Eby': [3933, 4036], 'Xiao': [3935, 4038], 'Nature.': [3939, 4042, 4231, 4252], '427:': [3941, 4044], '167-171Crossref': [3942, 4045], '(453)': [3945, 4048], 'Bcl10-induced': [3948], 'Bcl10-associated': [3957], 'ubiquitin-conjugating': [3962], 'enzyme': [3963], 'UBC13.': [3964], '48-linked': [3967], 'polyubiquitination,': [3968], 'generally': [3970], 'case': [3981], 'IκB),': [3983], 'intermolecular': [3993], '(49Weissman': [3995], 'A.M.': [3996], '2:': [4003], '169-178Crossref': [4004], '(1269)': [4007], 'Notably': [4010], 'K399R': [4011], 'was': [4013], 'reconstituting': [4016], 'IKKγ-deficient': [4021], 'line': [4025, 4594], 'precise': [4052], 'activates': [4058], 'unknown': [4062], 'presumably': [4064], 'involves': [4065], 'toward': [4078, 5256], 'IκB.': [4079], 'Bcl10': [4080, 4119], 'IKKγ,': [4087], 'IKKα,': [4088], 'IKKβ': [4090], 'stabilizing': [4101], 'association': [4102, 4117], 'CARMA-1.': [4121], 'That': [4122], 'further': [4126], 'suggested': [4138], 'studies,': [4144], 'observation': [4147, 5047], 'adaptor': [4151], 'Shc': [4153], 'transport': [4158], 'c-Rel': [4160], '(50Iwashima': [4161], 'Takamatsu': [4163], 'Yamagishi': [4165], 'Hatanaka': [4167], 'Huang': [4169], 'Y.Y.': [4170], 'McGinty': [4171], 'Yamasaki': [4173], 'Koike': [4175], 'Proc.': [4177], 'Natl.': [4178], 'Acad.': [4179], 'U.': [4181], '99:': [4185], '4544-4549Crossref': [4186], '(27)': [4189], 'Rip2': [4198], 'RICK,': [4202], 'CARDIAK,': [4203], 'CCK,': [4204], 'Ripk2)': [4206], '(51Kobayashi': [4215], 'Inohara': [4217], 'Hernandez': [4219], 'Galan': [4221], 'J.E.': [4222], 'Janeway': [4225], 'C.A.': [4226], 'Medzhitov': [4227], 'Flavell': [4229], 'R.A.': [4230], '416:': [4233, 4254], '194-199Crossref': [4234], '(757)': [4237], '52Chin': [4240], 'A.I.': [4241], 'Dempsey': [4242], 'P.W.': [4243], 'Bruhn': [4244], 'Miller': [4246], 'J.F.': [4247], 'Cheng': [4250], '190-194Crossref': [4255], '(335)': [4258], '53Ruefli-Brasse': [4261], 'Lee': [4263], 'W.P.': [4264], 'Hurst': [4265], '279:': [4273], '1570-1574Abstract': [4274], '(79)': [4282], 'additional': [4288, 4825], 'clearly': [4291], 'II,': [4302], 'MEKK1,': [4303], 'MEKK2,': [4304], 'MLK3,': [4305], 'COT/Tpl-2,': [4306], 'NIK': [4308], 'NFAT—In': [4325], 'comparison': [4326], 'much': [4337], 'simpler': [4338], '(54Crabtree': [4339, 4778], 'G.R.': [4340, 4683, 4779, 5194], 'Olson': [4341, 4780, 5195], 'E.N.': [4342, 4781, 5196], 'S67-S79Abstract': [4346, 4785, 5200], '(1121)': [4354, 4793, 5208], '55Hogan': [4357, 4796, 5211], 'P.G.': [4358, 4797, 5212], 'Chen': [4359, 4798, 5213], 'Nardone': [4361, 4800, 5215], 'Rao': [4363, 4802, 5217], 'Genes': [4365, 4804, 5219], 'Dev.': [4366, 4805, 5220], '2205-2232Crossref': [4369, 4808, 5223], '(1590)': [4372, 4811, 5226], 'rate-limiting': [4376], 'removal': [4383], 'phosphate': [4386], 'groups': [4387], 'N': [4390], 'terminus': [4391], 'Phosphorylation': [4396], 'masks': [4400], 'when': [4408, 4846], 'phosphates': [4410], 'removed': [4412], 'nucleus': [4418], 'genes.': [4425], 'specifically': [4431], 'carried': [4432, 4744], 'out': [4433, 4745], 'Ca2+-calmodulin-regulated': [4436], 'phosphatase,': [4437], 'calcineurin.': [4438], 'Consequently,': [4439], 'IP3': [4449], 'increase': [4451], 'Ca2+,': [4454], 'component': [4458], 'playing': [4467], '56Tybulewicz': [4488], 'Ardouin': [4490], 'Prisco': [4492], 'Reynolds': [4494], '42-52Crossref': [4500], '(92)': [4503], 'importance': [4507], 'manifest': [4515], 'steps.': [4518], 'mouse': [4520, 4603], 'loss': [4523], 'greatly': [4529], 'impaired': [4530, 4537], 'flux': [4532], 'Tec,': [4541], 'effects': [4545], 'least': [4548], 'part': [4550], 'cells.': [4558], 'Keeping': [4559], 'mind': [4561], 'previously': [4563], 'discussed': [4564], 'defect': [4565], 'metabolism': [4568], 'characteristic': [4571], 'Vav-1-negative': [4590, 4658], 'fails': [4595], 'recapitulate': [4597], 'phenotype': [4599], 'Vav-1–/–': [4602], 'However,': [4653, 5324], 'despite': [4654], 'basal': [4656], 'still': [4662, 5327], 'show': [4663], 'attributed': [4670], 'opening': [4673], 'release-activated': [4676], 'channels': [4677], '(57Winslow': [4678], 'Neilson': [4680], 'J.R.': [4681], 'Crabtree': [4682], '15:': [4688], '299-307Crossref': [4689], '(103)': [4692], 'Scholar)': [4694], 'Jnk': [4697, 4959, 5002, 5011], '(38Cao': [4699], 'activation/deactivation': [4723], 'cycle': [4724], 'completed': [4726], 'rephosphorylation': [4729], 'causes': [4733], 'repartition': [4736], 'cytosol.': [4739], 'reaction': [4741], 'CK1,': [4752], 'CK2,': [4753], 'Erk,': [4755], 'p38;': [4757], 'however,': [4758], 'GSK3': [4762, 4818, 4838, 4872], 'dominant': [4770], 'inactivating': [4773, 4860], 'prominent': [4815], 'deactivation': [4821], 'provides': [4823], 'inactivated': [4845], 'serine': [4851], 'residue.': [4852], 'particularly': [4855, 5144], 'effective': [4856], 'phosphorylating': [4858], 'GSK3.': [4861], 'Thus,': [4862], 'induces': [4865], 'phosphorylation,': [4868], 'inactivation': [4870], 'slower': [4875], 'rate': [4876], 'inactivation.': [4879], 'AP-1—Like': [4880], 'AP-1': [4886, 4896, 4936, 5063, 5105, 5127, 5178], 'PKCθ–/–': [4891], '58Arendt': [4916, 5027], 'C.W.': [4917, 5028, 5087], 'Soos': [4920, 5031, 5090], 'T.J.': [4921, 5032, 5091], '323-330Crossref': [4929, 5040, 5099], '(94)': [4932, 5043, 5102], 'factor': [4938], 'dimers': [4942], 'c-Jun': [4944, 4957, 4966, 5085], 'c-Fos': [4946, 4964, 5083], 'up-regulation': [4962], '(59Foletta': [4968], 'V.C.': [4969, 5230], 'Segal': [4970, 5231], 'D.H.': [4971, 5232], 'Cohen': [4972, 5233], 'Leukocyte': [4975, 5236], '63:': [4978, 5239], '139-152Crossref': [4979, 5240], '(319)': [4982, 5243], 'Even': [4985], 'though': [4986], 'transient': [4987], 'overexpression': [4988], 'lines': [4994, 5310], 'suggests': [4995], 'ablation': [5005, 5050], 'impair': [5010], 'Jnk1': [5052], 'Jnk2': [5054], 'interferes': [5055], 'consistent': [5067], 'Jnk-independent': [5076], 'involving': [5079], 'and/or': [5084], '(58Arendt': [5086], 'PKCθ-independent': [5110], 'c-Fos.': [5122], 'An': [5123], 'factors.': [5141], 'promoter': [5155, 5169], 'cooperatively': [5156], 'Likewise': [5162], 'CD28RE': [5164], 'cooperative': [5172], '54Crabtree': [5193], '59Foletta': [5229], 'Over': [5246], 'past': [5248], '15': [5249], 'tremendous': [5251], 'strides': [5252], 'made': [5255], 'understanding': [5257, 5330], 'initiated': [5262], 'great': [5287], '(maybe': [5289], 'even': [5290], 'most)': [5291], 'players': [5295, 5319], 'now': [5297], 'identified,': [5299], 'begun': [5303], 'comprehend': [5305], 'few': [5307], 'some': [5312], 'ways': [5315], 'another.': [5323], 'far': [5328], 'entirety,': [5335], 'thing': [5338], 'clear:': [5340], 'simple': [5345], 'matter': [5346], 'dangerous': [5355], 'inappropriately': [5357], 'potential': [5363], 'be,': [5365], 'probably': [5368], 'good': [5370], 'thing.': [5371]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2092284137', 'counts_by_year': [{'year': 2024, 'cited_by_count': 4}, {'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 3}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 3}, {'year': 2018, 'cited_by_count': 5}, {'year': 2017, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 3}, {'year': 2015, 'cited_by_count': 5}, {'year': 2014, 'cited_by_count': 3}, {'year': 2013, 'cited_by_count': 8}, {'year': 2012, 'cited_by_count': 7}], 'updated_date': '2025-01-08T03:23:55.307479', 'created_date': '2016-06-24'}
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