Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2092272732', 'doi': 'https://doi.org/10.1523/jneurosci.3815-05.2006', 'title': 'HMGB1, a Novel Cytokine-Like Mediator Linking Acute Neuronal Death and Delayed Neuroinflammation in the Postischemic Brain', 'display_name': 'HMGB1, a Novel Cytokine-Like Mediator Linking Acute Neuronal Death and Delayed Neuroinflammation in the Postischemic Brain', 'publication_year': 2006, 'publication_date': '2006-06-14', 'ids': {'openalex': 'https://openalex.org/W2092272732', 'doi': 'https://doi.org/10.1523/jneurosci.3815-05.2006', 'mag': '2092272732', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/16775128', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/6674036'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1523/jneurosci.3815-05.2006', 'pdf_url': 'https://www.jneurosci.org/content/jneuro/26/24/6413.full.pdf', 'source': {'id': 'https://openalex.org/S5555990', 'display_name': 'Journal of Neuroscience', 'issn_l': '0270-6474', 'issn': ['0270-6474', '1529-2401'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319739', 'host_organization_name': 'Society for Neuroscience', 'host_organization_lineage': ['https://openalex.org/P4310319739'], 'host_organization_lineage_names': ['Society for Neuroscience'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://www.jneurosci.org/content/jneuro/26/24/6413.full.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5112849309', 'display_name': 'J.-B. Kim', 'orcid': 'https://orcid.org/0000-0002-4915-804X'}, 'institutions': [{'id': 'https://openalex.org/I196345858', 'display_name': 'Chungnam National University', 'ror': 'https://ror.org/0227as991', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I196345858']}, {'id': 'https://openalex.org/I191879574', 'display_name': 'Inha University', 'ror': 'https://ror.org/01easw929', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I191879574']}, {'id': 'https://openalex.org/I139264467', 'display_name': 'Seoul National University', 'ror': 'https://ror.org/04h9pn542', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I139264467']}, {'id': 'https://openalex.org/I138925566', 'display_name': 'Ewha Womans University', 'ror': 'https://ror.org/053fp5c05', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I138925566']}, {'id': 'https://openalex.org/I4575257', 'display_name': 'Hanyang University', 'ror': 'https://ror.org/046865y68', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I4575257']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'J.-B. Kim', 'raw_affiliation_strings': ['1Department of Anatomy and Center for Advanced Medical Education (BK21 project), Inha University School of Medicine, Inchon 400-712, Korea, 2Department of Biochemistry, Chungnam National University, Daejeon 305-764, Korea, 3School of Chemistry and Molecular Engineering, Seoul National University, Seoul 151-742, Korea, 4Department of Bioengineering, School of Engineering, Hanyang University, Seoul 133-791, Korea, and 5Division of Nano Sciences and Department of Life Sciences, Ewha Womans University, Seoul 110-783, Korea'], 'affiliations': [{'raw_affiliation_string': '1Department of Anatomy and Center for Advanced Medical Education (BK21 project), Inha University School of Medicine, Inchon 400-712, Korea, 2Department of Biochemistry, Chungnam National University, Daejeon 305-764, Korea, 3School of Chemistry and Molecular Engineering, Seoul National University, Seoul 151-742, Korea, 4Department of Bioengineering, School of Engineering, Hanyang University, Seoul 133-791, Korea, and 5Division of Nano Sciences and Department of Life Sciences, Ewha Womans University, Seoul 110-783, Korea', 'institution_ids': ['https://openalex.org/I196345858', 'https://openalex.org/I191879574', 'https://openalex.org/I139264467', 'https://openalex.org/I138925566', 'https://openalex.org/I4575257']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5030226541', 'display_name': 'Jiwon Choi', 'orcid': 'https://orcid.org/0009-0000-0950-8212'}, 'institutions': [{'id': 'https://openalex.org/I196345858', 'display_name': 'Chungnam National University', 'ror': 'https://ror.org/0227as991', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I196345858']}, {'id': 'https://openalex.org/I4575257', 'display_name': 'Hanyang University', 'ror': 'https://ror.org/046865y68', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I4575257']}, {'id': 'https://openalex.org/I139264467', 'display_name': 'Seoul National University', 'ror': 'https://ror.org/04h9pn542', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I139264467']}, {'id': 'https://openalex.org/I191879574', 'display_name': 'Inha University', 'ror': 'https://ror.org/01easw929', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I191879574']}, {'id': 'https://openalex.org/I138925566', 'display_name': 'Ewha Womans University', 'ror': 'https://ror.org/053fp5c05', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I138925566']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'J. Sig Choi', 'raw_affiliation_strings': ['1Department of Anatomy and Center for Advanced Medical Education (BK21 project), Inha University School of Medicine, Inchon 400-712, Korea, 2Department of Biochemistry, Chungnam National University, Daejeon 305-764, Korea, 3School of Chemistry and Molecular Engineering, Seoul National University, Seoul 151-742, Korea, 4Department of Bioengineering, School of Engineering, Hanyang University, Seoul 133-791, Korea, and 5Division of Nano Sciences and Department of Life Sciences, Ewha Womans University, Seoul 110-783, Korea'], 'affiliations': [{'raw_affiliation_string': '1Department of Anatomy and Center for Advanced Medical Education (BK21 project), Inha University School of Medicine, Inchon 400-712, Korea, 2Department of Biochemistry, Chungnam National University, Daejeon 305-764, Korea, 3School of Chemistry and Molecular Engineering, Seoul National University, Seoul 151-742, Korea, 4Department of Bioengineering, School of Engineering, Hanyang University, Seoul 133-791, Korea, and 5Division of Nano Sciences and Department of Life Sciences, Ewha Womans University, Seoul 110-783, Korea', 'institution_ids': ['https://openalex.org/I196345858', 'https://openalex.org/I4575257', 'https://openalex.org/I139264467', 'https://openalex.org/I191879574', 'https://openalex.org/I138925566']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5076246530', 'display_name': 'Young‐Mi Yu', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I196345858', 'display_name': 'Chungnam National University', 'ror': 'https://ror.org/0227as991', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I196345858']}, {'id': 'https://openalex.org/I191879574', 'display_name': 'Inha University', 'ror': 'https://ror.org/01easw929', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I191879574']}, {'id': 'https://openalex.org/I4575257', 'display_name': 'Hanyang University', 'ror': 'https://ror.org/046865y68', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I4575257']}, {'id': 'https://openalex.org/I139264467', 'display_name': 'Seoul National University', 'ror': 'https://ror.org/04h9pn542', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I139264467']}, {'id': 'https://openalex.org/I138925566', 'display_name': 'Ewha Womans University', 'ror': 'https://ror.org/053fp5c05', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I138925566']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Y.-M. Yu', 'raw_affiliation_strings': ['1Department of Anatomy and Center for Advanced Medical Education (BK21 project), Inha University School of Medicine, Inchon 400-712, Korea, 2Department of Biochemistry, Chungnam National University, Daejeon 305-764, Korea, 3School of Chemistry and Molecular Engineering, Seoul National University, Seoul 151-742, Korea, 4Department of Bioengineering, School of Engineering, Hanyang University, Seoul 133-791, Korea, and 5Division of Nano Sciences and Department of Life Sciences, Ewha Womans University, Seoul 110-783, Korea'], 'affiliations': [{'raw_affiliation_string': '1Department of Anatomy and Center for Advanced Medical Education (BK21 project), Inha University School of Medicine, Inchon 400-712, Korea, 2Department of Biochemistry, Chungnam National University, Daejeon 305-764, Korea, 3School of Chemistry and Molecular Engineering, Seoul National University, Seoul 151-742, Korea, 4Department of Bioengineering, School of Engineering, Hanyang University, Seoul 133-791, Korea, and 5Division of Nano Sciences and Department of Life Sciences, Ewha Womans University, Seoul 110-783, Korea', 'institution_ids': ['https://openalex.org/I196345858', 'https://openalex.org/I191879574', 'https://openalex.org/I4575257', 'https://openalex.org/I139264467', 'https://openalex.org/I138925566']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5078855746', 'display_name': 'Ki‐Woong Nam', 'orcid': 'https://orcid.org/0000-0001-7514-6264'}, 'institutions': [{'id': 'https://openalex.org/I191879574', 'display_name': 'Inha University', 'ror': 'https://ror.org/01easw929', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I191879574']}, {'id': 'https://openalex.org/I4575257', 'display_name': 'Hanyang University', 'ror': 'https://ror.org/046865y68', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I4575257']}, {'id': 'https://openalex.org/I139264467', 'display_name': 'Seoul National University', 'ror': 'https://ror.org/04h9pn542', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I139264467']}, {'id': 'https://openalex.org/I138925566', 'display_name': 'Ewha Womans University', 'ror': 'https://ror.org/053fp5c05', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I138925566']}, {'id': 'https://openalex.org/I196345858', 'display_name': 'Chungnam National University', 'ror': 'https://ror.org/0227as991', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I196345858']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'K. Nam', 'raw_affiliation_strings': ['1Department of Anatomy and Center for Advanced Medical Education (BK21 project), Inha University School of Medicine, Inchon 400-712, Korea, 2Department of Biochemistry, Chungnam National University, Daejeon 305-764, Korea, 3School of Chemistry and Molecular Engineering, Seoul National University, Seoul 151-742, Korea, 4Department of Bioengineering, School of Engineering, Hanyang University, Seoul 133-791, Korea, and 5Division of Nano Sciences and Department of Life Sciences, Ewha Womans University, Seoul 110-783, Korea'], 'affiliations': [{'raw_affiliation_string': '1Department of Anatomy and Center for Advanced Medical Education (BK21 project), Inha University School of Medicine, Inchon 400-712, Korea, 2Department of Biochemistry, Chungnam National University, Daejeon 305-764, Korea, 3School of Chemistry and Molecular Engineering, Seoul National University, Seoul 151-742, Korea, 4Department of Bioengineering, School of Engineering, Hanyang University, Seoul 133-791, Korea, and 5Division of Nano Sciences and Department of Life Sciences, Ewha Womans University, Seoul 110-783, Korea', 'institution_ids': ['https://openalex.org/I191879574', 'https://openalex.org/I4575257', 'https://openalex.org/I139264467', 'https://openalex.org/I138925566', 'https://openalex.org/I196345858']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5014512871', 'display_name': 'Chunshu Piao', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I196345858', 'display_name': 'Chungnam National University', 'ror': 'https://ror.org/0227as991', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I196345858']}, {'id': 'https://openalex.org/I191879574', 'display_name': 'Inha University', 'ror': 'https://ror.org/01easw929', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I191879574']}, {'id': 'https://openalex.org/I4575257', 'display_name': 'Hanyang University', 'ror': 'https://ror.org/046865y68', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I4575257']}, {'id': 'https://openalex.org/I139264467', 'display_name': 'Seoul National University', 'ror': 'https://ror.org/04h9pn542', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I139264467']}, {'id': 'https://openalex.org/I138925566', 'display_name': 'Ewha Womans University', 'ror': 'https://ror.org/053fp5c05', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I138925566']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'C.-S. Piao', 'raw_affiliation_strings': ['1Department of Anatomy and Center for Advanced Medical Education (BK21 project), Inha University School of Medicine, Inchon 400-712, Korea, 2Department of Biochemistry, Chungnam National University, Daejeon 305-764, Korea, 3School of Chemistry and Molecular Engineering, Seoul National University, Seoul 151-742, Korea, 4Department of Bioengineering, School of Engineering, Hanyang University, Seoul 133-791, Korea, and 5Division of Nano Sciences and Department of Life Sciences, Ewha Womans University, Seoul 110-783, Korea'], 'affiliations': [{'raw_affiliation_string': '1Department of Anatomy and Center for Advanced Medical Education (BK21 project), Inha University School of Medicine, Inchon 400-712, Korea, 2Department of Biochemistry, Chungnam National University, Daejeon 305-764, Korea, 3School of Chemistry and Molecular Engineering, Seoul National University, Seoul 151-742, Korea, 4Department of Bioengineering, School of Engineering, Hanyang University, Seoul 133-791, Korea, and 5Division of Nano Sciences and Department of Life Sciences, Ewha Womans University, Seoul 110-783, Korea', 'institution_ids': ['https://openalex.org/I196345858', 'https://openalex.org/I191879574', 'https://openalex.org/I4575257', 'https://openalex.org/I139264467', 'https://openalex.org/I138925566']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100452227', 'display_name': 'Sangwoo Kim', 'orcid': 'https://orcid.org/0009-0009-1054-4603'}, 'institutions': [{'id': 'https://openalex.org/I196345858', 'display_name': 'Chungnam National University', 'ror': 'https://ror.org/0227as991', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I196345858']}, {'id': 'https://openalex.org/I191879574', 'display_name': 'Inha University', 'ror': 'https://ror.org/01easw929', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I191879574']}, {'id': 'https://openalex.org/I4575257', 'display_name': 'Hanyang University', 'ror': 'https://ror.org/046865y68', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I4575257']}, {'id': 'https://openalex.org/I139264467', 'display_name': 'Seoul National University', 'ror': 'https://ror.org/04h9pn542', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I139264467']}, {'id': 'https://openalex.org/I138925566', 'display_name': 'Ewha Womans University', 'ror': 'https://ror.org/053fp5c05', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I138925566']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'S.-W. Kim', 'raw_affiliation_strings': ['1Department of Anatomy and Center for Advanced Medical Education (BK21 project), Inha University School of Medicine, Inchon 400-712, Korea, 2Department of Biochemistry, Chungnam National University, Daejeon 305-764, Korea, 3School of Chemistry and Molecular Engineering, Seoul National University, Seoul 151-742, Korea, 4Department of Bioengineering, School of Engineering, Hanyang University, Seoul 133-791, Korea, and 5Division of Nano Sciences and Department of Life Sciences, Ewha Womans University, Seoul 110-783, Korea'], 'affiliations': [{'raw_affiliation_string': '1Department of Anatomy and Center for Advanced Medical Education (BK21 project), Inha University School of Medicine, Inchon 400-712, Korea, 2Department of Biochemistry, Chungnam National University, Daejeon 305-764, Korea, 3School of Chemistry and Molecular Engineering, Seoul National University, Seoul 151-742, Korea, 4Department of Bioengineering, School of Engineering, Hanyang University, Seoul 133-791, Korea, and 5Division of Nano Sciences and Department of Life Sciences, Ewha Womans University, Seoul 110-783, Korea', 'institution_ids': ['https://openalex.org/I196345858', 'https://openalex.org/I191879574', 'https://openalex.org/I4575257', 'https://openalex.org/I139264467', 'https://openalex.org/I138925566']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5067302706', 'display_name': 'M.-H. Lee', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I196345858', 'display_name': 'Chungnam National University', 'ror': 'https://ror.org/0227as991', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I196345858']}, {'id': 'https://openalex.org/I191879574', 'display_name': 'Inha University', 'ror': 'https://ror.org/01easw929', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I191879574']}, {'id': 'https://openalex.org/I4575257', 'display_name': 'Hanyang University', 'ror': 'https://ror.org/046865y68', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I4575257']}, {'id': 'https://openalex.org/I139264467', 'display_name': 'Seoul National University', 'ror': 'https://ror.org/04h9pn542', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I139264467']}, {'id': 'https://openalex.org/I138925566', 'display_name': 'Ewha Womans University', 'ror': 'https://ror.org/053fp5c05', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I138925566']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'M.-H. Lee', 'raw_affiliation_strings': ['1Department of Anatomy and Center for Advanced Medical Education (BK21 project), Inha University School of Medicine, Inchon 400-712, Korea, 2Department of Biochemistry, Chungnam National University, Daejeon 305-764, Korea, 3School of Chemistry and Molecular Engineering, Seoul National University, Seoul 151-742, Korea, 4Department of Bioengineering, School of Engineering, Hanyang University, Seoul 133-791, Korea, and 5Division of Nano Sciences and Department of Life Sciences, Ewha Womans University, Seoul 110-783, Korea'], 'affiliations': [{'raw_affiliation_string': '1Department of Anatomy and Center for Advanced Medical Education (BK21 project), Inha University School of Medicine, Inchon 400-712, Korea, 2Department of Biochemistry, Chungnam National University, Daejeon 305-764, Korea, 3School of Chemistry and Molecular Engineering, Seoul National University, Seoul 151-742, Korea, 4Department of Bioengineering, School of Engineering, Hanyang University, Seoul 133-791, Korea, and 5Division of Nano Sciences and Department of Life Sciences, Ewha Womans University, Seoul 110-783, Korea', 'institution_ids': ['https://openalex.org/I196345858', 'https://openalex.org/I191879574', 'https://openalex.org/I4575257', 'https://openalex.org/I139264467', 'https://openalex.org/I138925566']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5072837083', 'display_name': 'Pyung‐Lim Han', 'orcid': 'https://orcid.org/0000-0002-1735-6746'}, 'institutions': [{'id': 'https://openalex.org/I196345858', 'display_name': 'Chungnam National University', 'ror': 'https://ror.org/0227as991', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I196345858']}, {'id': 'https://openalex.org/I139264467', 'display_name': 'Seoul National University', 'ror': 'https://ror.org/04h9pn542', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I139264467']}, {'id': 'https://openalex.org/I191879574', 'display_name': 'Inha University', 'ror': 'https://ror.org/01easw929', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I191879574']}, {'id': 'https://openalex.org/I4575257', 'display_name': 'Hanyang University', 'ror': 'https://ror.org/046865y68', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I4575257']}, {'id': 'https://openalex.org/I138925566', 'display_name': 'Ewha Womans University', 'ror': 'https://ror.org/053fp5c05', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I138925566']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'P.-L. Han', 'raw_affiliation_strings': ['1Department of Anatomy and Center for Advanced Medical Education (BK21 project), Inha University School of Medicine, Inchon 400-712, Korea, 2Department of Biochemistry, Chungnam National University, Daejeon 305-764, Korea, 3School of Chemistry and Molecular Engineering, Seoul National University, Seoul 151-742, Korea, 4Department of Bioengineering, School of Engineering, Hanyang University, Seoul 133-791, Korea, and 5Division of Nano Sciences and Department of Life Sciences, Ewha Womans University, Seoul 110-783, Korea'], 'affiliations': [{'raw_affiliation_string': '1Department of Anatomy and Center for Advanced Medical Education (BK21 project), Inha University School of Medicine, Inchon 400-712, Korea, 2Department of Biochemistry, Chungnam National University, Daejeon 305-764, Korea, 3School of Chemistry and Molecular Engineering, Seoul National University, Seoul 151-742, Korea, 4Department of Bioengineering, School of Engineering, Hanyang University, Seoul 133-791, Korea, and 5Division of Nano Sciences and Department of Life Sciences, Ewha Womans University, Seoul 110-783, Korea', 'institution_ids': ['https://openalex.org/I196345858', 'https://openalex.org/I139264467', 'https://openalex.org/I191879574', 'https://openalex.org/I4575257', 'https://openalex.org/I138925566']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5013426015', 'display_name': 'J.-s. Park', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I196345858', 'display_name': 'Chungnam National University', 'ror': 'https://ror.org/0227as991', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I196345858']}, {'id': 'https://openalex.org/I191879574', 'display_name': 'Inha University', 'ror': 'https://ror.org/01easw929', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I191879574']}, {'id': 'https://openalex.org/I4575257', 'display_name': 'Hanyang University', 'ror': 'https://ror.org/046865y68', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I4575257']}, {'id': 'https://openalex.org/I139264467', 'display_name': 'Seoul National University', 'ror': 'https://ror.org/04h9pn542', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I139264467']}, {'id': 'https://openalex.org/I138925566', 'display_name': 'Ewha Womans University', 'ror': 'https://ror.org/053fp5c05', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I138925566']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'J.-s. Park', 'raw_affiliation_strings': ['1Department of Anatomy and Center for Advanced Medical Education (BK21 project), Inha University School of Medicine, Inchon 400-712, Korea, 2Department of Biochemistry, Chungnam National University, Daejeon 305-764, Korea, 3School of Chemistry and Molecular Engineering, Seoul National University, Seoul 151-742, Korea, 4Department of Bioengineering, School of Engineering, Hanyang University, Seoul 133-791, Korea, and 5Division of Nano Sciences and Department of Life Sciences, Ewha Womans University, Seoul 110-783, Korea'], 'affiliations': [{'raw_affiliation_string': '1Department of Anatomy and Center for Advanced Medical Education (BK21 project), Inha University School of Medicine, Inchon 400-712, Korea, 2Department of Biochemistry, Chungnam National University, Daejeon 305-764, Korea, 3School of Chemistry and Molecular Engineering, Seoul National University, Seoul 151-742, Korea, 4Department of Bioengineering, School of Engineering, Hanyang University, Seoul 133-791, Korea, and 5Division of Nano Sciences and Department of Life Sciences, Ewha Womans University, Seoul 110-783, Korea', 'institution_ids': ['https://openalex.org/I196345858', 'https://openalex.org/I191879574', 'https://openalex.org/I4575257', 'https://openalex.org/I139264467', 'https://openalex.org/I138925566']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5100747404', 'display_name': 'Jae Kwan Lee', 'orcid': 'https://orcid.org/0000-0003-3101-6403'}, 'institutions': [{'id': 'https://openalex.org/I4575257', 'display_name': 'Hanyang University', 'ror': 'https://ror.org/046865y68', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I4575257']}, {'id': 'https://openalex.org/I196345858', 'display_name': 'Chungnam National University', 'ror': 'https://ror.org/0227as991', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I196345858']}, {'id': 'https://openalex.org/I191879574', 'display_name': 'Inha University', 'ror': 'https://ror.org/01easw929', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I191879574']}, {'id': 'https://openalex.org/I139264467', 'display_name': 'Seoul National University', 'ror': 'https://ror.org/04h9pn542', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I139264467']}, {'id': 'https://openalex.org/I138925566', 'display_name': 'Ewha Womans University', 'ror': 'https://ror.org/053fp5c05', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I138925566']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'J.-K. Lee', 'raw_affiliation_strings': ['1Department of Anatomy and Center for Advanced Medical Education (BK21 project), Inha University School of Medicine, Inchon 400-712, Korea, 2Department of Biochemistry, Chungnam National University, Daejeon 305-764, Korea, 3School of Chemistry and Molecular Engineering, Seoul National University, Seoul 151-742, Korea, 4Department of Bioengineering, School of Engineering, Hanyang University, Seoul 133-791, Korea, and 5Division of Nano Sciences and Department of Life Sciences, Ewha Womans University, Seoul 110-783, Korea'], 'affiliations': [{'raw_affiliation_string': '1Department of Anatomy and Center for Advanced Medical Education (BK21 project), Inha University School of Medicine, Inchon 400-712, Korea, 2Department of Biochemistry, Chungnam National University, Daejeon 305-764, Korea, 3School of Chemistry and Molecular Engineering, Seoul National University, Seoul 151-742, Korea, 4Department of Bioengineering, School of Engineering, Hanyang University, Seoul 133-791, Korea, and 5Division of Nano Sciences and Department of Life Sciences, Ewha Womans University, Seoul 110-783, Korea', 'institution_ids': ['https://openalex.org/I4575257', 'https://openalex.org/I196345858', 'https://openalex.org/I191879574', 'https://openalex.org/I139264467', 'https://openalex.org/I138925566']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 5, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 18.987, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 554, 'citation_normalized_percentile': {'value': 0.999404, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '26', 'issue': '24', 'first_page': '6413', 'last_page': '6421'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11142', 'display_name': 'Advanced Glycation End Products research', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1308', 'display_name': 'Clinical Biochemistry'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11142', 'display_name': 'Advanced Glycation End Products research', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1308', 'display_name': 'Clinical Biochemistry'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11266', 'display_name': 'Neuroinflammation and Neurodegeneration Mechanisms', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/2808', 'display_name': 'Neurology'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10227', 'display_name': 'Acute Ischemic Stroke Management', 'score': 0.9793, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/hmgb1', 'display_name': 'HMGB1', 'score': 0.9154862}, {'id': 'https://openalex.org/keywords/proinflammatory-cytokine', 'display_name': 'Proinflammatory cytokine', 'score': 0.8586464}, {'id': 'https://openalex.org/keywords/excitotoxicity', 'display_name': 'Excitotoxicity', 'score': 0.8048694}], 'concepts': [{'id': 'https://openalex.org/C2780545709', 'wikidata': 'https://www.wikidata.org/wiki/Q21130552', 'display_name': 'HMGB1', 'level': 3, 'score': 0.9154862}, {'id': 'https://openalex.org/C164027704', 'wikidata': 'https://www.wikidata.org/wiki/Q3491837', 'display_name': 'Proinflammatory cytokine', 'level': 3, 'score': 0.8586464}, {'id': 'https://openalex.org/C87753298', 'wikidata': 'https://www.wikidata.org/wiki/Q17157137', 'display_name': 'Neuroinflammation', 'level': 3, 'score': 0.85791063}, {'id': 'https://openalex.org/C2781012912', 'wikidata': 'https://www.wikidata.org/wiki/Q901117', 'display_name': 'Excitotoxicity', 'level': 4, 'score': 0.8048694}, {'id': 'https://openalex.org/C2779830541', 'wikidata': 'https://www.wikidata.org/wiki/Q1622829', 'display_name': 'Microglia', 'level': 3, 'score': 0.7501177}, {'id': 'https://openalex.org/C28406088', 'wikidata': 'https://www.wikidata.org/wiki/Q5571762', 'display_name': 'Extracellular', 'level': 2, 'score': 0.51203877}, {'id': 'https://openalex.org/C2776914184', 'wikidata': 'https://www.wikidata.org/wiki/Q101991', 'display_name': 'Inflammation', 'level': 2, 'score': 0.4951798}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.45421138}, {'id': 'https://openalex.org/C2778690821', 'wikidata': 'https://www.wikidata.org/wiki/Q212354', 'display_name': 'Cytokine', 'level': 2, 'score': 0.4137353}, {'id': 'https://openalex.org/C169760540', 'wikidata': 'https://www.wikidata.org/wiki/Q207011', 'display_name': 'Neuroscience', 'level': 1, 'score': 0.41221195}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.3962217}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.39589822}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.32807875}, {'id': 'https://openalex.org/C67018056', 'wikidata': 'https://www.wikidata.org/wiki/Q414896', 'display_name': 'NMDA receptor', 'level': 3, 'score': 0.24105364}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.07191837}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.06995514}], 'mesh': [{'descriptor_ui': 'D001921', 'descriptor_name': 'Brain', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D006609', 'descriptor_name': 'High Mobility Group Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D007249', 'descriptor_name': 'Inflammation', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': True}, {'descriptor_ui': 'D007249', 'descriptor_name': 'Inflammation', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D009474', 'descriptor_name': 'Neurons', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D012097', 'descriptor_name': 'Repressor Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015152', 'descriptor_name': 'Blotting, Northern', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015152', 'descriptor_name': 'Blotting, Northern', 'qualifier_ui': 'Q000379', 'qualifier_name': 'methods', 'is_major_topic': False}, {'descriptor_ui': 'D015153', 'descriptor_name': 'Blotting, Western', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015153', 'descriptor_name': 'Blotting, Western', 'qualifier_ui': 'Q000379', 'qualifier_name': 'methods', 'is_major_topic': False}, {'descriptor_ui': 'D001921', 'descriptor_name': 'Brain', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001921', 'descriptor_name': 'Brain', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D016923', 'descriptor_name': 'Cell Death', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016923', 'descriptor_name': 'Cell Death', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D002478', 'descriptor_name': 'Cells, Cultured', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017077', 'descriptor_name': 'Culture Media, Conditioned', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D017077', 'descriptor_name': 'Culture Media, Conditioned', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004622', 'descriptor_name': 'Embryo, Mammalian', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004791', 'descriptor_name': 'Enzyme Inhibitors', 'qualifier_ui': 'Q000633', 'qualifier_name': 'toxicity', 'is_major_topic': False}, {'descriptor_ui': 'D004791', 'descriptor_name': 'Enzyme Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018690', 'descriptor_name': 'Excitatory Amino Acid Agonists', 'qualifier_ui': 'Q000633', 'qualifier_name': 'toxicity', 'is_major_topic': False}, {'descriptor_ui': 'D018690', 'descriptor_name': 'Excitatory Amino Acid Agonists', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015870', 'descriptor_name': 'Gene Expression', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D015870', 'descriptor_name': 'Gene Expression', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D015870', 'descriptor_name': 'Gene Expression', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D024243', 'descriptor_name': 'HMGB1 Protein', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006609', 'descriptor_name': 'High Mobility Group Proteins', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D006609', 'descriptor_name': 'High Mobility Group Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020244', 'descriptor_name': 'Infarction, Middle Cerebral Artery', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020244', 'descriptor_name': 'Infarction, Middle Cerebral Artery', 'qualifier_ui': 'Q000150', 'qualifier_name': 'complications', 'is_major_topic': False}, {'descriptor_ui': 'D020244', 'descriptor_name': 'Infarction, Middle Cerebral Artery', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D020244', 'descriptor_name': 'Infarction, Middle Cerebral Artery', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D007249', 'descriptor_name': 'Inflammation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007249', 'descriptor_name': 'Inflammation', 'qualifier_ui': 'Q000209', 'qualifier_name': 'etiology', 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017628', 'descriptor_name': 'Microglia', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017628', 'descriptor_name': 'Microglia', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D017628', 'descriptor_name': 'Microglia', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D016202', 'descriptor_name': 'N-Methylaspartate', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016202', 'descriptor_name': 'N-Methylaspartate', 'qualifier_ui': 'Q000633', 'qualifier_name': 'toxicity', 'is_major_topic': False}, {'descriptor_ui': 'D009474', 'descriptor_name': 'Neurons', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009474', 'descriptor_name': 'Neurons', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D012333', 'descriptor_name': 'RNA, Messenger', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012333', 'descriptor_name': 'RNA, Messenger', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D051381', 'descriptor_name': 'Rats', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017207', 'descriptor_name': 'Rats, Sprague-Dawley', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012097', 'descriptor_name': 'Repressor Proteins', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D012097', 'descriptor_name': 'Repressor Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020133', 'descriptor_name': 'Reverse Transcriptase Polymerase Chain Reaction', 'qualifier_ui': 'Q000379', 'qualifier_name': 'methods', 'is_major_topic': False}, {'descriptor_ui': 'D020133', 'descriptor_name': 'Reverse Transcriptase Polymerase Chain Reaction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019311', 'descriptor_name': 'Staurosporine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019311', 'descriptor_name': 'Staurosporine', 'qualifier_ui': 'Q000633', 'qualifier_name': 'toxicity', 'is_major_topic': False}, {'descriptor_ui': 'D013997', 'descriptor_name': 'Time Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014162', 'descriptor_name': 'Transfection', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014162', 'descriptor_name': 'Transfection', 'qualifier_ui': 'Q000379', 'qualifier_name': 'methods', 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1523/jneurosci.3815-05.2006', 'pdf_url': 'https://www.jneurosci.org/content/jneuro/26/24/6413.full.pdf', 'source': {'id': 'https://openalex.org/S5555990', 'display_name': 'Journal of Neuroscience', 'issn_l': '0270-6474', 'issn': ['0270-6474', '1529-2401'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319739', 'host_organization_name': 'Society for Neuroscience', 'host_organization_lineage': ['https://openalex.org/P4310319739'], 'host_organization_lineage_names': ['Society for Neuroscience'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc6674036', 'pdf_url': 'https://europepmc.org/articles/pmc6674036?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6674036', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/16775128', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1523/jneurosci.3815-05.2006', 'pdf_url': 'https://www.jneurosci.org/content/jneuro/26/24/6413.full.pdf', 'source': {'id': 'https://openalex.org/S5555990', 'display_name': 'Journal of Neuroscience', 'issn_l': '0270-6474', 'issn': ['0270-6474', '1529-2401'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319739', 'host_organization_name': 'Society for Neuroscience', 'host_organization_lineage': ['https://openalex.org/P4310319739'], 'host_organization_lineage_names': ['Society for Neuroscience'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'score': 0.86, 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 40, 'referenced_works': ['https://openalex.org/W1976140941', 'https://openalex.org/W1990596307', 'https://openalex.org/W1994190235', 'https://openalex.org/W2002273297', 'https://openalex.org/W2004266769', 'https://openalex.org/W2011085652', 'https://openalex.org/W2015510501', 'https://openalex.org/W2016363609', 'https://openalex.org/W2020622209', 'https://openalex.org/W2023295028', 'https://openalex.org/W2026885016', 'https://openalex.org/W2028294482', 'https://openalex.org/W2029068688', 'https://openalex.org/W2034311142', 'https://openalex.org/W2042481675', 'https://openalex.org/W2046569869', 'https://openalex.org/W2058668043', 'https://openalex.org/W2059217150', 'https://openalex.org/W2061163173', 'https://openalex.org/W2067853554', 'https://openalex.org/W2068729872', 'https://openalex.org/W2072847038', 'https://openalex.org/W2080126967', 'https://openalex.org/W2089006322', 'https://openalex.org/W2104938297', 'https://openalex.org/W2112505121', 'https://openalex.org/W2115293825', 'https://openalex.org/W2135131688', 'https://openalex.org/W2135374161', 'https://openalex.org/W2144918294', 'https://openalex.org/W2146807706', 'https://openalex.org/W2160369507', 'https://openalex.org/W2161619169', 'https://openalex.org/W2164714222', 'https://openalex.org/W2169079203', 'https://openalex.org/W2170546457', 'https://openalex.org/W2171028311', 'https://openalex.org/W2988187534', 'https://openalex.org/W4251556082', 'https://openalex.org/W4256375950'], 'related_works': ['https://openalex.org/W4310076785', 'https://openalex.org/W3137999900', 'https://openalex.org/W3107395714', 'https://openalex.org/W2965172925', 'https://openalex.org/W2804482952', 'https://openalex.org/W2365473896', 'https://openalex.org/W2097236514', 'https://openalex.org/W1978256486', 'https://openalex.org/W1541957757', 'https://openalex.org/W1490007860'], 'abstract_inverted_index': {'Cerebral': [0], 'ischemic': [1, 11, 56], 'injury': [2], 'proceeds': [3], 'with': [4, 14, 144], 'excitotoxicity-induced': [5, 191], 'acute': [6, 192], 'neuronal': [7], 'death': [8], 'in': [9, 18, 64, 73, 93, 107, 119, 173, 199], 'the': [10, 19, 24, 51, 65, 74, 94, 137, 168, 200], 'core': [12], 'and': [13, 58, 82, 111, 125, 195], 'delayed': [15, 196], 'damage': [16, 193], 'processes': [17, 31, 194, 198], 'penumbra.': [20], 'However,': [21], 'knowledge': [22], 'concerning': [23], 'direct': [25], 'mediators': [26], 'that': [27, 37, 59, 87, 180, 189], 'connect': [28], 'these': [29, 129, 177], 'two': [30], 'is': [32, 47], 'limited.': [33], 'Here,': [34], 'we': [35], 'demonstrate': [36], 'high-mobility': [38], 'group': [39], 'box': [40], '1': [41], '(HMGB1),': [42], 'a': [43, 90, 184], 'nonhistone': [44], 'DNA-binding': [45], 'protein,': [46], 'massively': [48], 'released': [49], 'into': [50], 'extracellular': [52, 102], 'space': [53], 'immediately': [54], 'after': [55], 'insult': [57], 'it': [60], 'subsequently': [61], 'induces': [62], 'neuroinflammation': [63], 'postischemic': [66, 75, 201], 'brain.': [67, 202], 'Short': [68], 'hairpin': [69], '(sh)RNA-mediated': [70], 'HMGB1': [71, 88, 103, 114, 146, 161, 172, 181], 'downregulation': [72], 'brain': [76, 140], 'suppressed': [77], 'infarct': [78], 'size,': [79], 'microglia': [80, 135], 'activation,': [81, 136, 150], 'proinflammatory': [83, 98, 186], 'marker': [84], 'induction,': [85], 'indicating': [86], 'plays': [89], 'crucial': [91], 'role': [92, 170], 'inflammatory': [95, 197], 'process.': [96], 'The': [97], 'cytokine-like': [99, 187], 'function': [100], 'of': [101, 139, 171], 'was': [104, 115], 'further': [105], 'verified': [106], 'primary': [108, 121], 'cortical': [109, 122], 'cultures': [110, 130], 'microglial': [112, 149, 174], 'cultures.': [113], 'found': [116, 132], 'to': [117, 133], 'accumulate': [118], 'NMDA-treated': [120], 'culture': [123], 'media,': [124], 'supernatants': [126], 'collected': [127], 'from': [128], 'were': [131], 'trigger': [134], 'hallmark': [138], 'inflammation.': [141], 'Moreover,': [142], 'treatment': [143, 158], 'recombinant': [145], 'also': [147], 'induced': [148], 'but': [151], 'HMGB1-depleted': [152], 'supernatant': [153], 'produced': [154], 'by': [155, 160], 'anti-HMGB1': [156], 'antibody': [157], 'or': [159], 'shRNA': [162], 'expression': [163], 'did': [164], 'not,': [165], 'thus': [166], 'demonstrating': [167], 'essential': [169], 'activation.': [175], 'Together,': [176], 'results': [178], 'indicate': [179], 'functions': [182], 'as': [183], 'novel': [185], 'factor': [188], 'connects': [190]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2092272732', 'counts_by_year': [{'year': 2024, 'cited_by_count': 22}, {'year': 2023, 'cited_by_count': 20}, {'year': 2022, 'cited_by_count': 27}, {'year': 2021, 'cited_by_count': 20}, {'year': 2020, 'cited_by_count': 29}, {'year': 2019, 'cited_by_count': 23}, {'year': 2018, 'cited_by_count': 33}, {'year': 2017, 'cited_by_count': 39}, {'year': 2016, 'cited_by_count': 47}, {'year': 2015, 'cited_by_count': 39}, {'year': 2014, 'cited_by_count': 40}, {'year': 2013, 'cited_by_count': 48}, {'year': 2012, 'cited_by_count': 30}], 'updated_date': '2024-12-31T12:12:23.878472', 'created_date': '2016-06-24'}