Laeverin/Aminopeptidase Q, a Novel Bestatin-sensitive Leucine Aminopeptidase Belonging to the M1 Family of Aminopeptidases

Name: Work Video:
Duration: 3 min 30 s
Masato Maruyama; Akira Hattori; Yoshikuni Goto; Masamichi Ueda; Michiyuki Maeda; Hiroshi Fujiwara; Masafumi Tsujimoto
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'https://openalex.org/W2084159218', 'https://openalex.org/W2051730930', 'https://openalex.org/W2051687768', 'https://openalex.org/W2044628742', 'https://openalex.org/W2009948972', 'https://openalex.org/W1967771459', 'https://openalex.org/W170435099', 'https://openalex.org/W1675997988'], 'abstract_inverted_index': {'Laeverin/aminopeptidase': [0, 201], 'Q': [1, 202, 1466], '(APQ)': [2, 203], 'is': [3, 46, 62, 173, 204, 247, 263, 374, 467, 604, 629, 898, 1091, 1357, 1383, 1406, 1518, 2483, 2592, 3022, 3232, 3681, 3812, 3821, 4000, 4011, 4257], 'a': [4, 31, 74, 79, 97, 107, 174, 205, 232, 275, 280, 298, 308, 375, 504, 525, 543, 680, 1257, 1358, 1384, 1447, 1457, 1489, 1538, 1545, 1682, 1716, 1935, 1970, 2020, 2041, 2054, 2075, 2099, 2130, 2240, 2256, 2261, 2298, 2313, 2370, 2374, 2396, 2484, 2593, 2653, 2671, 2701, 2745, 2940, 2979, 3113, 3174, 3234, 3569, 3683, 3736, 3766, 3822, 3828, 3842, 3888, 4001, 4043, 4221, 4271], 'cell': [5, 206, 1258, 2319, 2416, 4265], 'surface': [6, 207, 1259], 'protein': [7, 32, 208, 233, 1362, 1382, 1393, 1496, 1504, 2305, 2315], 'specifically': [8, 209, 1310], 'expressed': [9, 73, 140, 210, 274, 341, 1262, 1311, 2296], 'on': [10, 211, 1326, 1338, 1934, 2347, 2380, 2414, 2681, 2952, 3015, 3078, 3097, 3493, 3573, 3643], 'human': [11, 76, 188, 212, 277, 389, 438, 1264, 1322, 1329, 1452, 1498, 1551, 1622, 1799, 2258, 2285, 2335, 3393], 'embryo-derived': [12, 213], 'extravillous': [13, 214, 520, 1265], 'trophoblasts': [14, 215, 1266], 'that': [15, 27, 94, 116, 171, 181, 216, 228, 295, 317, 372, 382, 471, 821, 1305, 1353, 1380, 1408, 2291, 2408, 2474, 2590, 2794, 2809, 2963, 3111, 3230, 3603, 3678, 3761, 3819, 3995, 4013, 4028], 'invades': [16, 217], 'the': [17, 28, 41, 49, 55, 59, 66, 122, 142, 147, 155, 182, 198, 218, 229, 242, 250, 256, 260, 267, 323, 343, 348, 356, 383, 399, 414, 422, 472, 485, 546, 552, 620, 642, 749, 905, 909, 1052, 1055, 1083, 1306, 1313, 1317, 1321, 1327, 1332, 1354, 1365, 1376, 1381, 1416, 1444, 1451, 1469, 1519, 1523, 1529, 1549, 1554, 1571, 1592, 1602, 1618, 1631, 1668, 1752, 1818, 1903, 1966, 2007, 2109, 2235, 2245, 2270, 2281, 2303, 2331, 2341, 2409, 2415, 2419, 2430, 2456, 2470, 2488, 2562, 2605, 2619, 2639, 2658, 2682, 2707, 2739, 2752, 2780, 2784, 2797, 2817, 2829, 2836, 2946, 2953, 2973, 3016, 3025, 3041, 3079, 3098, 3118, 3150, 3167, 3243, 3377, 3381, 3389, 3420, 3444, 3608, 3611, 3627, 3632, 3656, 3669, 3688, 3743, 3748, 3769, 3858, 3869, 3894, 3929, 3936, 3961, 3991, 3996, 4007, 4019, 4163, 4194, 4229, 4238, 4251, 4260, 4264, 4327], 'uterus': [18, 219], 'during': [19, 220, 1419, 2418], 'placentation.': [20, 221], 'The': [21, 222, 1349, 1500, 1565, 1664, 1711, 1738, 1809, 1838, 1863, 1871, 1917, 1928, 2081, 2125, 2366, 2571, 2660, 2693, 2728, 2928, 3090, 3130, 3557], 'cDNA': [22, 223, 1350], 'cloning': [23, 224, 1351], 'of': [24, 48, 52, 58, 126, 158, 194, 225, 249, 253, 259, 327, 359, 395, 407, 417, 434, 487, 528, 535, 548, 554, 644, 683, 907, 911, 1057, 1082, 1086, 1316, 1389, 1446, 1472, 1480, 1494, 1497, 1502, 1528, 1537, 1541, 1574, 1620, 1635, 1646, 1658, 1671, 1750, 1790, 1793, 1797, 1815, 1823, 1840, 1853, 1860, 1888, 1923, 1973, 2023, 2044, 2057, 2078, 2084, 2093, 2116, 2157, 2239, 2248, 2283, 2321, 2334, 2349, 2357, 2362, 2377, 2399, 2432, 2459, 2487, 2492, 2565, 2598, 2601, 2609, 2641, 2657, 2685, 2704, 2732, 2738, 2755, 2783, 2832, 2855, 2873, 2948, 2956, 2968, 3019, 3044, 3076, 3082, 3092, 3101, 3122, 3153, 3361, 3371, 3380, 3391, 3412, 3423, 3443, 3489, 3497, 3607, 3610, 3626, 3634, 3660, 3668, 3685, 3693, 3738, 3750, 3768, 3815, 3825, 3831, 3860, 3893, 3935, 3945, 3964, 4004, 4022, 4165, 4231, 4236, 4254, 4326, 4331, 4340], 'Laeverin/APQ': [25, 39, 77, 95, 117, 159, 172, 226, 240, 278, 296, 318, 360, 373, 1473, 1543, 1593, 1672, 2118, 2249, 2259, 2293, 2336, 2841, 3231, 3816, 3826, 4005, 4218], 'revealed': [26, 227, 3229], 'sequence': [29, 230, 1373, 2394, 2398, 2431, 4174], 'encodes': [30, 231], 'with': [33, 149, 234, 350, 614, 1553, 1601, 1630, 1655, 1703, 1729, 1734, 1765, 1803, 1902, 1965, 2019, 2053, 2098, 2144, 2373, 2840, 3024, 3169, 3396, 3827, 3931], '990': [34, 235], 'amino': [35, 124, 236, 325, 405, 2392, 2401, 3847, 3866, 4038, 4240, 4246], 'acid': [36, 125, 237, 326, 406, 2016, 2029, 2036, 2063, 2070, 2107, 2393, 2402, 3848, 4039, 4241], 'residues,': [37, 238], 'and': [38, 86, 134, 179, 239, 287, 335, 380, 425, 432, 481, 506, 556, 562, 568, 625, 628, 693, 757, 914, 1060, 1078, 1325, 1343, 1363, 1371, 1404, 1460, 1512, 1525, 1535, 1609, 1678, 1701, 1731, 1744, 1817, 1856, 1878, 1930, 1959, 2017, 2047, 2142, 2166, 2180, 2194, 2208, 2214, 2225, 2351, 2385, 2455, 2580, 2633, 2645, 2697, 2721, 2759, 2765, 2823, 3002, 3135, 3143, 3149, 3189, 3210, 3417, 3433, 3457, 3476, 3817, 3878, 3891, 3943, 3976, 4167, 4198, 4208, 4233, 4262, 4338], 'contains': [40, 241], 'HEXXHX18E': [42, 243, 426, 1369], 'gluzincin': [43, 244, 1386], 'motif,': [44, 245, 1368, 1378], 'which': [45, 137, 246, 338, 2466, 2834, 3021, 3407, 4170, 4237, 4256], 'characteristic': [47, 248, 2485, 3241], 'M1': [50, 151, 251, 352, 415, 473, 1065, 1087, 1387, 1531, 2490, 2843, 2970, 3027, 3171, 3236, 3244, 3413, 4029], 'family': [51, 252, 416, 1088, 1388, 2491, 2844, 3245], 'aminopeptidases,': [53, 152, 254, 353, 1089, 2971, 3172, 3414], 'although': [54, 104, 255, 305, 3651, 4183], 'exopeptidase': [56, 257], 'motif': [57, 258, 1370], 'family,': [60, 261], 'GAMEN,': [61, 262], 'uniquely': [63, 264], 'substituted': [64, 265], 'for': [65, 109, 266, 310, 429, 484, 736, 1415, 1640, 1786, 1835, 1976, 1988, 2230, 2706, 2734, 2741, 2757, 2786, 2795, 2800, 2810, 3368, 3405, 3845, 4018], 'HAMEN': [67, 268, 1372], 'sequence.': [68, 269], 'In': [69, 144, 270, 345, 1044, 1484, 2750, 3032, 3459], 'this': [70, 271, 1485, 3618, 3907], 'study,': [71, 272, 1486], 'we': [72, 114, 273, 315, 741, 1487, 2252, 2268, 2329, 2434, 2560, 3387, 3630, 3727, 3855, 4161, 4226], 'recombinant': [75, 276, 1495, 1588, 1613, 1621, 1632, 1798, 2117, 2257, 2284, 2304], 'using': [78, 279, 1456, 1605, 1945, 2105, 2260, 2668], 'baculovirus': [80, 281, 1633, 2262], 'expression': [81, 282, 1400, 1619, 2263], 'system,': [82, 283], 'purified': [83, 284, 1503, 1759, 2330, 2367, 2448, 2572], 'to': [84, 120, 146, 285, 321, 347, 564, 607, 631, 678, 739, 816, 824, 828, 901, 1064, 1093, 1375, 1462, 1476, 1508, 1586, 1681, 1715, 1746, 2030, 2064, 2254, 2338, 2452, 2463, 2469, 2665, 2744, 2773, 2805, 3039, 3087, 3242, 3375, 3623, 3674, 3700, 3775, 3917, 3978, 3986, 4034, 4042, 4178, 4187, 4224, 4270, 4344], 'homogeneity,': [85, 286], 'characterized': [87, 288], 'its': [88, 289, 688, 1398, 1409, 1481, 1510, 1558, 2274, 3400], 'enzymatic': [89, 290, 430, 1096, 1410, 1470, 1513, 1526, 2246, 3017, 3042, 3080, 3099, 3239, 4020], 'properties.': [90, 291], 'It': [91, 292, 466, 1302, 3108, 4010, 4024], 'was': [92, 118, 293, 319, 675, 1253, 1303, 1309, 1394, 1561, 1568, 1581, 1674, 1763, 1801, 1830, 1843, 1919, 2119, 2127, 2189, 2197, 2216, 2289, 2306, 2364, 2405, 2411, 2439, 2450, 2467, 2476, 2574, 2623, 2649, 2663, 2736, 2826, 3037, 3084, 3109, 3117, 3429, 3448, 3671, 3707, 3755, 3764, 3773, 3887, 3901, 3915, 3967, 4333, 4342], 'found': [93, 115, 294, 316, 2962, 3818, 4181], 'had': [96, 297, 3217], 'broad': [98, 299, 2654], 'substrate': [99, 300, 2655, 2672, 2710, 3613, 3684, 3737, 3767, 4003], 'specificity': [100, 301, 2656], 'toward': [101, 302, 2611, 2687, 2875, 3850], 'synthetic': [102, 303, 2613, 2689, 3851], 'substrate,': [103, 304, 3890], 'it': [105, 306, 612, 638, 1090, 1405, 1464, 1506, 2288, 2438, 3820], 'showed': [106, 307, 3011, 3436, 3841, 4220], 'preference': [108, 309, 3844, 4223], 'Leu-4-methylcoumaryl-7-amide.': [110, 311], 'Searching': [111, 312], 'natural': [112, 313, 3372, 3394], 'substrates,': [113, 314, 1806, 2614, 3386], 'able': [119, 320, 4033], 'cleave': [121, 322], 'N-terminal': [123, 324, 404, 2391, 3895, 3937, 4037, 4239, 4328], 'several': [127, 328, 1046, 2688, 2969, 3861], 'peptides': [128, 196, 329, 397, 826, 1977, 1989, 2048, 2085, 3395, 3463, 3602, 3636, 3640, 3863, 4185], 'such': [129, 330, 559, 1067], 'as': [130, 331, 560, 608, 1068, 1256, 2108, 2277, 2297, 2312, 2478, 2670, 4200], 'angiotensin': [131, 332, 684], 'III,': [132, 333], 'kisspeptin-10,': [133, 334, 4255], 'endokinin': [135, 336, 1960, 1991, 3453, 3465, 3875, 3941], 'C,': [136, 337, 1992, 3454, 3876], 'are': [138, 339, 475, 482, 1062, 1873, 2424, 2879, 2887, 2897, 2930, 3103, 3408, 3501, 3559, 4016, 4031, 4243], 'abundantly': [139, 340], 'in': [141, 187, 342, 388, 437, 477, 545, 619, 623, 641, 690, 748, 904, 1051, 1098, 1263, 1312, 1320, 1331, 1401, 1515, 1544, 1643, 1694, 1775, 1820, 1885, 1910, 2010, 2037, 2071, 2250, 2280, 2309, 2318, 2429, 2445, 2816, 2828, 2939, 2978, 3105, 3166, 3568, 3617, 3648, 3883, 3906, 3928, 4259], 'placenta.': [143, 344], 'contrast': [145, 346], 'case': [148, 349, 3168, 3930], 'other': [150, 164, 351, 365, 3026, 3170, 3462, 3689], 'bestatin': [153, 354], 'inhibited': [154, 355, 3177, 3419, 3655], 'aminopeptidase': [156, 166, 178, 357, 367, 379, 493, 511, 514, 517, 674, 897, 1069, 1072, 1449, 1465, 1795, 2683, 2954, 3115, 3237], 'activity': [157, 193, 358, 394, 431, 1471, 1796, 2608, 2955, 2976, 3018, 3043, 3081, 3100, 3179, 3197, 3422, 3496, 3659], 'much': [160, 361, 2791, 3988], 'more': [161, 362], 'effectively': [162, 363, 2977], 'than': [163, 364, 2317, 2776, 2793, 2808, 3990, 4006], 'known': [165, 366, 3094], 'inhibitors.': [167, 368], 'These': [168, 369, 2587], 'results': [169, 370, 1872, 2588], 'indicate': [170, 371], 'novel': [175, 376, 745, 1385, 1392, 1448, 1530, 3235], 'bestatin-sensitive': [176, 377], 'leucine': [177, 378, 492, 501, 753, 896], 'suggest': [180, 381, 2589], 'enzyme': [183, 384, 1819, 1904, 2410, 2573, 2785, 4195], 'plays': [184, 385, 542], 'important': [185, 386, 483, 1092, 1414], 'roles': [186, 387, 640, 3379], 'placentation': [189, 390], 'by': [190, 391, 550, 634, 1347, 1455, 1563, 1676, 1845, 1875, 1891, 1921, 2088, 2121, 2344, 2567, 2625, 2630, 2647, 3364, 3398, 3450, 3637, 3753, 4193, 4268], 'regulating': [191, 392], 'biological': [192, 393], 'key': [195, 396], 'at': [197, 398, 1557, 1651, 1783, 1832, 1849, 1907, 1969, 2040, 2074, 2154, 2273, 3180, 3200, 3222, 3483, 3614, 3662, 3868, 3969, 4175, 4196], 'embryo-maternal': [199, 400], 'interface.': [200, 401], 'Aminopeptidases': [402], 'hydrolyze': [403], 'proteins': [408, 737], 'or': [409, 1980, 2441, 3730, 3808], 'peptide': [410, 2227, 3373, 3491], 'substrates.': [411], 'Among': [412, 2618], 'them,': [413], 'zinc': [418, 1366], 'aminopeptidases': [419, 474, 746, 1066, 2493, 3028, 4030], '(gluzincin)': [420], 'shares': [421], 'consensus': [423], 'GAMEN': [424, 1377], 'motifs': [427], 'essential': [428], 'consists': [433], '11': [435], 'enzymes': [436, 820], 'beings': [439], '(1Hooper': [440], 'N.M.': [441], 'FEBS': [442], 'Lett.': [443], '1994;': [444], '31:': [445, 4319], '1-6Crossref': [446], 'Scopus': [447, 462, 599, 668, 729, 778, 808, 857, 891, 936, 965, 989, 1018, 1040, 1123, 1152, 1175, 1203, 1225, 1298, 1438, 2519, 2545, 2556, 2867, 3068, 3272, 3301, 3330, 3356, 3598, 3800, 4072, 4101, 4130, 4156, 4321], '(672)': [448], 'Google': [449, 464, 601, 670, 731, 780, 810, 859, 893, 938, 967, 991, 1020, 1042, 1125, 1154, 1177, 1205, 1227, 1250, 1300, 1440, 2521, 2547, 2558, 2869, 3070, 3274, 3303, 3332, 3358, 3600, 3802, 4074, 4103, 4132, 4158, 4323], 'Scholar,': [450, 781, 860, 939, 968, 992, 1021, 1126, 1155, 1178, 1206, 1228, 2522, 2548, 3275, 3304, 3333, 4075, 4104, 4133], '2Tsujimoto': [451], 'M.': [452, 581, 770, 795, 848, 869, 926, 947, 1010, 1285, 1287, 2511, 2532, 3055, 3259, 3293, 3322, 3343, 3585, 3787, 4059, 4093, 4122, 4143, 4300, 4304, 4316], 'Hattori': [453, 784, 839, 2504, 2525, 3048, 3248, 3315, 3336, 3578, 3780, 4048, 4115, 4136], 'A.': [454, 579, 764, 785, 840, 994, 1118, 1128, 1147, 1184, 1190, 1212, 1218, 2505, 2526, 3049, 3249, 3277, 3316, 3337, 3579, 3781, 4049, 4077, 4116, 4137, 4284], 'Biochim.': [455, 592], 'Biophys.': [456, 593, 1291], 'Acta.': [457, 594], '2005;': [458, 595, 887], '1751:': [459, 596], '9-18Crossref': [460], 'PubMed': [461, 598, 667, 728, 777, 807, 856, 890, 935, 964, 988, 1017, 1039, 1122, 1151, 1174, 1202, 1224, 1297, 1437, 2518, 2544, 2555, 3067, 3271, 3300, 3329, 3355, 3597, 3799, 4071, 4100, 4129, 4155], '(143)': [463], 'Scholar).': [465, 602, 671, 732, 811, 894, 1043, 1251, 1301, 3071, 3359, 3803, 4159, 4324], 'now': [468], 'becoming': [469], 'obvious': [470, 3110], 'involved': [476, 903], 'many': [478], 'physiological': [479, 1047, 3378], 'events': [480], 'maintenance': [486], 'homeostasis.': [488], 'For': [489, 1617], 'instance,': [490], 'placental': [491, 500], '(P-LAP)': [494], '2The': [495], 'abbreviations': [496], 'used': [497], 'are:': [498], 'P-LAP,': [499, 740], 'aminopeptidase;': [502], 'ADAM,': [503], 'disintegrin': [505], 'metalloproteinase;': [507], 'Ang,': [508], 'angiotensin;': [509], 'APA,': [510], 'A;': [512], 'APN,': [513, 2833], 'N;': [515], 'APQ,': [516], 'Q;': [518], 'EVT,': [519], 'trophoblast;': [521], 'MCA,': [522], '4-methylcoumaryl-7-amide;': [523], 'sLaeverin,': [524], 'soluble': [526, 1669, 2332], 'form': [527, 1670, 2333], 'Laeverin;': [529], 'MALDI-TOF,': [530], 'matrix-assisted': [531, 2089], 'laser': [532, 2090], 'desorption': [533, 2091], 'ionization-time': [534, 2092], 'flight;': [536], 'HPLC,': [537], 'high-performance': [538], 'liquid': [539], 'chromatography.': [540, 2124, 2570], '/oxytocinase': [541], 'role': [544], 'progression': [547], 'pregnancy': [549], 'controlling': [551], 'concentration': [553, 3202], 'uterotonic': [555], 'vasoactive': [557], 'hormones': [558, 1893, 2228, 3374, 3492], 'oxytocin': [561], 'vasopressin': [563], 'prevent': [565], 'premature': [566], 'delivery': [567], 'pre-eclampsia': [569], '(3Nomura': [570], 'S.': [571, 577, 591, 768, 787, 793, 844, 928, 945, 1000, 1006, 1101, 1117, 1134, 1146, 1159, 1232, 1273, 1281, 1289, 2501, 2509, 2530, 3053, 3251, 3257, 3283, 3289, 3312, 3320, 3341, 3583, 3785, 4051, 4057, 4083, 4089, 4112, 4120, 4141, 4280, 4290, 4308], 'Ito': [572], 'T.': [573, 706, 783, 836, 920, 922, 1002, 1033, 1230, 1240, 1244, 1271, 1275, 2497, 3247, 3285, 3308, 4047, 4085, 4108, 4276, 4298, 4302, 4310], 'Yamamoto': [574], 'E.': [575, 704, 1105], 'Sumigama': [576], 'Iwase': [578], 'Okada': [580], 'Shibata': [582], 'K.': [583, 587, 996, 1027, 1167, 1234, 1283, 2499, 2507, 3279, 3310, 3318, 4079, 4110, 4118, 4286], 'Ando': [584], 'H.': [585, 766, 791, 918, 998, 1029, 1269, 2495, 3255, 3281, 3306, 4055, 4081, 4106, 4282, 4312], 'Ino': [586], 'Kikkawa': [588], 'F.': [589, 875, 943, 974], 'Mizutani': [590, 767, 792, 1005, 2508, 2529, 3052, 3256, 3288, 3319, 3340, 3582, 3784, 4056, 4088, 4119, 4140], '19-25Crossref': [597], '(41)': [600], 'P-LAP': [603], 'also': [605, 676, 899, 2650, 3010, 3954, 4219], 'referred': [606], 'insulin-regulated': [609], 'aminopeptidase,': [610, 1532], 'because': [611, 1479, 2779], 'colocalizes': [613], 'insulin-responsive': [615], 'glucose': [616], 'transporter': [617], '4': [618], 'same': [621], 'vesicle': [622], 'adipocyte': [624], 'muscle': [626], 'cells': [627, 1342, 1346, 1585, 1598, 1625, 2324], 'translocated': [630], 'plasma': [632], 'membrane': [633, 1324, 2417], 'insulin': [635], 'stimulation,': [636], 'suggesting': [637, 687, 1379, 2407, 3760, 3994], 'has': [639, 1364, 1442, 4025], 'pathogenesis': [643], 'diabetes': [645], '(4Keller': [646], 'S.R.': [647], 'Scott': [648], 'H.M.': [649], 'Mastick': [650], 'C.C.': [651], 'Aebersold': [652], 'R.': [653, 1031, 1216], 'Lienhard': [654], 'G.E.': [655], 'J.': [656, 708, 717, 771, 796, 958, 977, 1011, 1025, 1169, 1191, 1219, 1245, 2513, 2533, 3056, 3260, 3294, 3324, 3344, 3586, 3788, 4060, 4094, 4124, 4144], 'Biol.': [657, 718, 797, 978, 1192, 2534, 3057, 3261, 3345, 3587, 3789, 4061, 4145], 'Chem.': [658, 719, 798, 979, 1193, 2535, 3058, 3262, 3346, 3588, 3790, 4062, 4146], '1995;': [659, 1194], '270:': [660, 1195], '23612-23618Abstract': [661], 'Full': [662, 664, 723, 725, 802, 804, 983, 985, 1197, 1199, 2539, 2541, 3062, 3064, 3266, 3268, 3350, 3352, 3592, 3594, 3794, 3796, 4066, 4068, 4150, 4152], 'Text': [663, 665, 724, 726, 803, 805, 984, 986, 1198, 1200, 2540, 2542, 3063, 3065, 3267, 3269, 3351, 3353, 3593, 3595, 3795, 3797, 4067, 4069, 4151, 4153], 'PDF': [666, 727, 806, 987, 1201, 2543, 3066, 3270, 3354, 3596, 3798, 4070, 4154], '(297)': [669], 'Recently,': [672], 'P-LAP/insulin-regulated': [673], 'shown': [677, 1304, 2444, 3038, 3104, 3647, 3774, 3882], 'be': [679, 817, 902, 1413, 1477, 2295, 2666, 2806, 3621, 3624, 3735, 3987], 'specific': [681, 3131, 3151], 'receptor': [682], 'IV,': [685], 'further': [686, 1747, 3716], 'significance': [689, 1085], 'memory': [691], 'retention': [692], 'retrieval': [694], '(5Albiston': [695], 'A.L.': [696, 850], 'McDowall': [697], 'S.G.': [698], 'Matsacos': [699], 'D.': [700, 871, 879, 955, 1163], 'Sim': [701], 'P.': [702, 1109, 1138], 'Clune': [703], 'Mustafa': [705], 'Lee': [707], 'Mendelsohn': [709], 'F.A.': [710], 'Simpson': [711], 'R.J.': [712], 'Connolly': [713], 'L.M.': [714, 1426], 'Chai': [715], 'S.Y.': [716], '2001;': [720, 4318], '276:': [721], '48623-48626Abstract': [722], '(409)': [730], 'By': [733], 'searching': [734], 'databases': [735], 'homologous': [738], 'have': [742, 4172], 'cloned': [743, 1569], 'two': [744], 'localized': [747], 'endoplasmic': [750], 'reticulum,': [751], 'adipocyte-derived': [752], 'aminopeptidase/endoplasmic': [754, 760], 'reticulum': [755, 761], 'aminopeptidase-1,': [756], 'leukocyte-derived': [758], 'arginine': [759], 'aminopeptidase-2': [762], '(6Hattori': [763], 'Matsumoto': [765, 997, 3280, 4080, 4281], 'Tsujimoto': [769, 794, 847, 1009, 2510, 2531, 3054, 3258, 3292, 3321, 3342, 3584, 3786, 4058, 4092, 4121, 4142], 'Biochem.': [772, 1012, 1170, 1290, 2514, 3295, 3325, 4095, 4125], '(Tokyo).': [773, 1013, 3296, 4096], '1999;': [774, 1148, 1171, 1247], '125:': [775], '931-938Crossref': [776], '(109)': [779], '7Tanioka': [782], 'Masuda': [786, 3250, 4050, 4293], 'Nomura': [788, 3252, 4052], 'Y.': [789, 873, 930, 1008, 1236, 1238, 1242, 1277, 1279, 2524, 2528, 3047, 3051, 3253, 3291, 3335, 3339, 3577, 3581, 3779, 3783, 4053, 4091, 4135, 4139, 4278, 4288, 4292, 4294, 4296], 'Nakayama': [790, 1024, 3254, 4054], '2003;': [799, 980, 1434, 3263, 4063], '278:': [800, 981, 3264, 4064], '32275-32283Abstract': [801, 3265, 4065], '(162)': [809, 3273, 4073], 'Subsequent': [812], 'studies': [813, 2680], 'indicated': [814, 2770], 'these': [815, 2774, 2801, 3227], 'final': [818], 'processing': [819], 'trim': [822], 'precursors': [823], 'antigen': [825, 1261, 1308, 1356], 'presented': [827], 'major': [829], 'histocompatibility': [830], 'complex': [831], 'class': [832], 'I': [833], 'molecules': [834], '(8Saric': [835], 'Chang': [837], 'S-C.': [838], 'York': [841], 'I.A.': [842], 'Markant': [843], 'Rock': [845], 'K.L.': [846], 'Goldberg': [849], 'Nat.': [851, 885, 1431], 'Immunol.': [852, 886], '2002;': [853, 932, 961, 1036], '3:': [854], '1169-1176Crossref': [855], '(425)': [858], '9Saveanu': [861], 'L.': [862, 877, 1157], 'Carroll': [863], 'O.': [864, 924, 4314], 'Lindo': [865], 'V.': [866], 'Del': [867], 'Val': [868], 'Lopez': [870], 'Lepelletier': [872], 'Greer': [874], 'Schomburg': [876], 'Fruci': [878], 'Niedermann': [880], 'G.': [881, 1161], 'van': [882], 'Endert': [883], 'P.M.': [884], '6:': [888], '689-697Crossref': [889], '(353)': [892], 'Adipocyte-derived': [895], 'reported': [900, 4027], 'regulation': [906, 1056], 'angiogenesis,': [908], 'shedding': [910], 'cytokine': [912], 'receptor,': [913, 4273], 'blood': [915, 1058], 'pressure': [916, 1059], '(10Miyashita': [917], 'Yamazaki': [919, 1235], 'Akada': [921], 'Niizeki': [923], 'Ogawa': [925], 'Nishikawa': [927], 'Sato': [929, 1276], 'Blood.': [931], '99:': [933], '3241-3249Crossref': [934], '(58)': [937], '11Cui': [940], 'X.': [941, 970], 'Hawari': [942, 973], 'Alsaaty': [944], 'Lawrence': [946], 'Combs': [948], 'C.A.': [949], 'Geng': [950], 'W.': [951], 'Rouhani': [952, 971], 'F.N.': [953, 972], 'Miskinis': [954], 'Levine': [956, 975], 'S.J.': [957, 976], 'Clin.': [959], 'Invest.': [960], '110:': [962], '515-526Crossref': [963], '(193)': [966], '12Cui': [969], '28677-28685Abstract': [982], '(115)': [990], '13Hattori': [993, 3276, 4076], 'Kitatani': [995, 3278, 4078], 'Miyazawa': [999, 3282, 4082], 'Rogi': [1001, 2496, 3284, 3307, 4084, 4107], 'Tsuruoka': [1003, 2502, 3286, 3313, 4086, 4113], 'N.': [1004, 1023, 2503, 3287, 3314, 4087, 4114], 'Natori': [1007, 3290, 4090], '2000;': [1014, 2515, 3297, 3326, 4097, 4126], '128:': [1015, 3298, 4098], '755-762Crossref': [1016, 3299, 4099], '(97)': [1019, 3302, 4102], '14Yamamoto': [1022], 'Yamakawa-Kobayashi': [1026], 'Hamaguchi': [1028], 'Miyazaki': [1030], 'Arinami': [1032], 'Hum.': [1034], 'Mutat.': [1035], '19:': [1037], '251-257Crossref': [1038], '(82)': [1041], 'addition,': [1045], 'and/or': [1048], 'pathological': [1049, 1084], 'functions': [1050], 'brain,': [1053], 'including': [1054], 'apoptosis,': [1061], 'assigned': [1063], 'A': [1070, 2812], '(APA),': [1071], 'N': [1073, 3870, 4176], '(APN),': [1074], 'thyrotropin-releasing': [1075], 'hormone-degrading': [1076], 'enzyme,': [1077], 'puromycin-sensitive': [1079], 'aminopeptidase.': [1080], 'Because': [1081, 2422, 2480, 3839, 4217], 'characterize': [1094, 1509], 'their': [1095], 'properties': [1097, 1514, 1527, 2247, 3240], 'detail': [1099], '(15Zini': [1100], 'Fournie-Zaluski': [1102, 1129], 'M.C.': [1103, 1130], 'Chauvel': [1104], 'Roques': [1106, 1135], 'B.P.': [1107, 1136], 'Corvol': [1108, 1137], 'Llorens-Cortes': [1110, 1139], 'C.': [1111, 1132, 1140, 1430, 4306], 'Proc.': [1112, 1141], 'Natl.': [1113, 1142], 'Acad.': [1114, 1143], 'Sci.': [1115, 1144], 'U.': [1116, 1145, 1214], '1996;': [1119], '93:': [1120], '11968-11973Crossref': [1121], '(291)': [1124], '16Reaux': [1127], 'David': [1131], 'Zini': [1133], '96:': [1149], '13415-13420Crossref': [1150], '(158)': [1153], '17Schomburg': [1156], 'Turwitt': [1158], 'Prescher': [1160], 'Lohmann': [1162], 'Horsthemke': [1164], 'B.': [1165], 'Bauer': [1166], 'Eur.': [1168, 2512, 3323, 4123], '265:': [1172], '415-422Crossref': [1173], '(44)': [1176], '18Constam': [1179], 'D.B.': [1180, 1210], 'Tobler': [1181], 'A.R.': [1182, 1208], 'Rensing-Ehl': [1183], 'Kemler': [1185], 'I.': [1186], 'Hersh': [1187], 'L.B.': [1188], 'Fontana': [1189, 1217], '26931-26939Abstract': [1196], '(177)': [1204], '19Tobler': [1207], 'Constam': [1209], 'Schmitt-Graff': [1211], 'Malipiero': [1213], 'Schlapbach': [1215], 'Neurochem.': [1220], '1997;': [1221], '68:': [1222], '889-897Crossref': [1223], '(57)': [1226], '20Osada': [1229], 'Ikegami': [1231], 'Takiguchi-Hayashi': [1233], 'Katoh-Fukui': [1237], 'Higashinakagawa': [1239], 'Sakaki': [1241], 'Takeuchi': [1243], 'Neurosci.': [1246], '15:': [1248], '6068-6078Crossref': [1249], 'Laeverin': [1252, 1396, 1453], 'originally': [1254], 'identified': [1255], 'CHL2': [1260, 1307, 1355], '(EVTs)': [1267], '(21Fujiwara': [1268], 'Higuchi': [1270], 'Yamada': [1272, 4301], 'Hirano': [1274], 'Nishioka': [1278], 'Yoshioka': [1280], 'Tatsumi': [1282], 'Ueda': [1284], 'Maeda': [1286], 'Fujii': [1288], 'Res.': [1292], 'Commun.': [1293], '2004;': [1294], '313:': [1295], '962-968Crossref': [1296], '(29)': [1299], 'outer': [1314], 'layer': [1315], 'chorion': [1318, 1402], 'laeve': [1319], 'fetal': [1323, 1339], 'migrating': [1328], 'EVTs': [1330], 'maternal': [1333, 1344], 'decidual': [1334, 1345], 'tissues': [1335], 'but': [1336, 3426], 'not': [1337, 2326, 2585, 2674, 2959, 3682, 3719, 3731, 3765, 3809, 3837, 4032, 4191, 4215], 'amniotic': [1340], 'epithelial': [1341], 'immunohistochemistry.': [1348], 'predicted': [1352, 1443, 2290], 'type': [1359, 2299], 'II': [1360, 2300, 3428, 3653, 3680], 'membrane-spanning': [1361], 'binding': [1367, 4269], 'similar': [1374, 2813], 'aminopeptidases.': [1390], 'This': [1391, 1517], 'named': [1395], 'after': [1397, 1610, 3641, 3721], 'restricted': [1399], 'laeve,': [1403], 'expected': [1407, 2471, 3741], 'action': [1411, 4021], 'will': [1412], 'EVT': [1417], 'function': [1418], 'pregnancy.': [1420], 'Another': [1421], 'group': [1422], '(22Puente': [1423], 'X.S.': [1424], 'Sanchez': [1425], 'Overall': [1427], 'C.M.': [1428], 'Lopez-Otin': [1429], 'Rev.': [1432], 'Genet.': [1433], '4:': [1435], '544-558Crossref': [1436], '(758)': [1439], 'Scholar)': [1441], 'existence': [1445], 'from': [1450, 1868, 1956, 1978, 1990, 2001, 2049, 2170, 2183, 2191, 2198, 2212, 2217, 2234, 2340, 2700, 3742, 3898, 3940], 'gene': [1454], 'genomic': [1458], 'search': [1459], 'proposed': [1461], 'name': [1463], '(APQ).': [1467], 'However,': [1468, 2778, 3072, 3715], 'still': [1474], 'remains': [1475], 'explored': [1478], 'limited': [1482], 'availability.': [1483], 'established': [1488], 'large': [1490], 'scale': [1491], 'production': [1492, 2282], 'system': [1493, 1949], 'Laeverin/APQ.': [1499, 1533, 3686, 4023, 4179], 'availability': [1501], 'made': [1505], 'possible': [1507, 3385], 'structure': [1511], 'detail.': [1516], 'first': [1520, 3992, 4008], 'report': [1521], 'describing': [1522], 'biochemical': [1524], 'Expression': [1534], 'Purification': [1536], 'Soluble': [1539], 'Form': [1540], 'Human': [1542, 2242], 'Baculovirus': [1546], 'System—cDNA': [1547], 'encoding': [1548], 'full-length': [1550, 2292], 'Laeverin/APQ-(1–990),': [1552], 'His6': [1555, 2271], 'tag': [1556, 2272], 'C': [1559, 1961, 2275, 3942, 3947, 3966, 3980], 'terminus,': [1560], 'generated': [1562, 1955, 2000], 'PCR.': [1564], 'amplified': [1566], 'fragment': [1567], 'into': [1570, 1583], 'EcoRI-XhoI': [1572], 'site': [1573], 'pFastBac1': [1575], 'vector': [1576], '(Invitrogen).': [1577], 'Then': [1578], 'resultant': [1579], 'plasmid': [1580], 'introduced': [1582, 2269], 'DH10Bac': [1584], 'produce': [1587, 2255], 'bacmid': [1589, 1603], 'DNA': [1590, 1604], 'containing': [1591, 1667, 1812, 1984, 1995, 2013, 2026, 2033, 2060, 2067, 2150], 'cDNA.': [1594], 'Next,': [1595], 'Sf9': [1596, 1624, 2323], 'insect': [1597], 'were': [1599, 1615, 1638, 1713, 1741, 1866, 1883, 1900, 1932, 1962, 2004, 2051, 2086, 2168, 2182, 2210, 2233, 2712, 2790, 2803, 3162, 3480, 3953, 4190], 'transfected': [1600], 'Cellfectin': [1606], 'reagent': [1607], '(Invitrogen),': [1608], '72-h': [1611], 'incubation,': [1612], 'baculoviruses': [1614], 'harvested.': [1616], 'Laeverin/APQ,': [1623, 4188], '(2.0': [1626], '×': [1627, 1686, 1725, 1940, 2134, 2894], '106/ml)': [1628], 'infected': [1629], '(multiplicity': [1634], 'infection': [1636], '=∼1–3)': [1637], 'cultured': [1639], '72': [1641], 'h': [1642], '3': [1644, 2355, 3088, 3904, 4336], 'liters': [1645, 2356], 'SFM-900': [1647], 'III': [1648, 3416, 3695, 3745], 'medium': [1649, 1666, 2311, 2343], '(Invitrogen)': [1650], '27': [1652], '°C': [1653, 1785, 1834, 1909], 'supplied': [1654], '8.0': [1656], 'ppm': [1657], 'O2': [1659], '(Cellmaster-1700,': [1660], 'Wakenyaku,': [1661], 'Kyoto,': [1662, 1691, 1952], 'Japan).': [1663, 1953, 2187, 2204], 'conditioned': [1665], '(sLaeverin/APQ)': [1673, 2337], 'collected': [1675], 'centrifugation,': [1677], 'then': [1679, 1732, 2603, 3366], 'applied': [1680, 1714], 'hydroxyapatite': [1683, 2350], 'column': [1684, 1723, 2008, 2138, 2569], '(2.5': [1685], '10': [1687, 1726, 1836, 2400, 3711, 3957], 'cm,': [1688], 'Nacalai': [1689, 1943, 2192], 'Tesque,': [1690, 2193], 'Japan)': [1692, 1899, 2141], 'equilibrated': [1693, 2009], '50': [1695, 1776, 2145], 'mm': [1696, 1705, 1736, 1777, 1825, 1912, 2146, 2152], 'Tris/HCl': [1697, 1826, 1913, 2147], 'buffer': [1698, 1708, 1780, 1827, 1914, 2148], '(pH': [1699, 1709, 1781, 1828, 1915], '7.5)': [1700, 1782], 'eluted': [1702, 1733, 1964, 2018, 2052, 2143, 2575], '100': [1704, 2151, 3484, 3615, 3663], 'sodium': [1706, 1778], 'phosphate': [1707, 1779], '7.5).': [1710], 'eluate': [1712], 'chelating-Sepharose': [1717], '(GE': [1718], 'Healthcare': [1719], 'Bio-Science,': [1720], 'Piscataway,': [1721], 'NJ)': [1722], '(1.0': [1724], 'cm)': [1727], 'preloaded': [1728], 'Ni2+': [1730, 3003], '200': [1735], 'imidazole.': [1737], 'active': [1739], 'fractions': [1740], 'collected,': [1742], 'concentrated,': [1743], 'subjected': [1745], 'characterization.': [1748], 'De-glycosylation': [1749], 'sLaeverin/APQ—After': [1751], 'heat': [1753], 'denature': [1754], '(100': [1755, 1761], '°C,': [1756], '5': [1757], 'min),': [1758], 'sLaeverin/APQ': [1760, 1800, 2363, 2368, 2449, 2461, 2475, 2566, 2591, 2610, 2626, 2648, 2686, 2705, 2733, 2756, 2874, 2957, 3083, 3102, 3123, 3178, 3196, 3424, 3661, 3754, 3840], 'μg/ml)': [1762, 1906], 'incubated': [1764, 1831, 1901], 'peptide:N-glycosidase': [1766, 2453], 'F': [1767], '(30': [1768], 'μg/ml,': [1769], 'New': [1770], 'England': [1771], 'Biolabs,': [1772], 'Beverly,': [1773], 'MA)': [1774], '37': [1784, 1833, 1908], '2': [1787], 'h.': [1788], 'Measurement': [1789], 'Aminopeptidase': [1791, 2599], 'Activity': [1792, 2600], 'Laeverin/APQ—The': [1794], 'determined': [1802, 2087, 2664], 'various': [1804, 1813, 2612, 2876, 2949, 3093, 3490], 'fluorogenic': [1805, 3612], 'aminoacyl-4-metheylcoumaryl-7-amides': [1807], '(aminoacyl-MCAs).': [1808], 'reaction': [1810, 1918], 'mixture': [1811], 'concentrations': [1814], 'aminoacyl-MCA': [1816], '0.5': [1821, 1974, 2045, 2079, 2158], 'ml': [1822], '25': [1824, 1911], '7.0)': [1829], 'min.': [1837, 3926, 3958], 'amount': [1839], '7-amino-4-methylcoumarin': [1841], 'released': [1842], 'measured': [1844, 2120, 2561, 2604], 'spectrofluorophotometry': [1846], '(F-2000,': [1847], 'Hitachi)': [1848], 'an': [1850, 1857, 1946, 2965, 3813, 4036], 'excitation': [1851], 'wavelength': [1852, 1859], '360': [1854], 'nm': [1855], 'emission': [1858], '460': [1861], 'nm.': [1862], 'kinetic': [1864, 2679, 2830], 'parameters': [1865, 2819, 2831, 2872], 'calculated': [1867, 2694, 2804], 'Lineweaver-Burk': [1869, 2702], 'plots.': [1870], 'represented': [1874], 'Km,': [1876, 2695], 'kcat,': [1877, 2696], 'kcat/Km': [1879, 2698], 'values.': [1880], 'All': [1881], 'measurements': [1882], 'performed': [1884, 2678], 'triplicate.': [1886], 'Cleavage': [1887, 3360], 'Peptide': [1889, 1896, 2184, 2236], 'Hormones': [1890], 'sLaeverin/APQ—Peptide': [1892], '(25': [1894], 'μm,': [1895, 2716, 3147, 3664, 4212], 'Institute,': [1897], 'Osaka,': [1898], '(2': [1905], '7.0).': [1916], 'terminated': [1920], 'adding': [1922], '2.5%': [1924], '(v/v)': [1925], 'formic': [1926], 'acid.': [1927, 1998], 'reactants': [1929], 'products': [1931], 'separated': [1933], 'reversed-phase': [1936], 'column,': [1937], 'COSMOSIL': [1938], '(4.6': [1939], '250': [1941], 'mm,': [1942], 'Tesque)': [1944], 'automated': [1947], 'HPLC': [1948], '(AT-10,': [1950], 'Shimadzu,': [1951], 'Peptides': [1954, 1999, 3363], 'angiotensins,': [1957, 3406], 'kallidin,': [1958, 1981, 3932], 'isocratically': [1963], 'following': [1967], 'buffers': [1968], 'flow': [1971, 2042, 2076, 2155], 'rate': [1972, 2043, 2077, 2156], 'ml/min:': [1975], 'angiotensins': [1979], '19%': [1982], 'acetonitrile': [1983, 1994, 2012, 2025, 2032, 2059, 2066], '0.086%': [1985, 2061], 'trifluoroacetic': [1986, 1997, 2015, 2028, 2035, 2062, 2069], 'acid;': [1987], '30%': [1993, 2031], '0.084%': [1996, 2034], 'dynorphin': [2002, 2231, 3455, 4234], 'A1–8': [2003, 2232], 'loaded': [2005, 2128], 'onto': [2006, 2129], '10%': [2011, 2024], '0.088%': [2014, 2027], 'linear': [2021, 2055], 'gradient': [2022, 2056], '20': [2038, 2072], 'min': [2039, 2073, 3712, 3905, 3971], 'ml/min,': [2046], 'kisspeptin-10': [2050, 4232, 4332, 4341], '20%': [2058], '40%': [2065], '0.082%': [2068], 'ml/min.': [2080, 2159], 'molecular': [2082, 2114, 2375, 2457, 2563], 'masses': [2083], 'flight': [2094], '(MALDI-TOF)': [2095], 'mass': [2096, 2101, 2115, 2376], 'spectrometry': [2097], 'REFLEX': [2100], 'spectrometer': [2102], '(Bruker-Franzen': [2103], 'Analytik)': [2104], 'α-cyano-4-hydroxycinnamic': [2106], 'matrix.': [2110], 'Gel': [2111], 'Filtration': [2112], 'Chromatography—The': [2113], 'gel': [2122], 'filtration': [2123], 'sample': [2126], 'TSK': [2131], 'G-3000SW': [2132], '(7.5': [2133], '300': [2135], 'mm)': [2136], 'ODS': [2137], '(TOSOH,': [2139], 'Tokyo,': [2140], '(pH7.5)': [2149], 'Na2SO4': [2153], 'Materials—Asp-,': [2160], 'Gln-,': [2161], 'Glu-,': [2162], 'Gly-,': [2163], 'Ile-,': [2164], 'Val-,': [2165], 'S-benzyl-Cys-MCAs': [2167], 'purchased': [2169, 2211], 'BACHEM': [2171], 'AG': [2172], '(Bubendorf,': [2173], 'Switzerland).': [2174], 'Ala-,': [2175, 2644], 'Arg-,': [2176, 2632], 'Leu-,': [2177], 'Lys-,': [2178], 'Met-,': [2179, 2631], 'Phe-MCAs': [2181], 'Institute': [2185], '(Osaka,': [2186], 'Bestatin': [2188], 'obtained': [2190], 'p-(4-amidinophenyl)methanesulfonyl': [2195, 3211], 'fluoride': [2196, 3212], 'Wako': [2199], 'Pure': [2200], 'Chemical': [2201], 'Industries': [2202], '(Tokyo,': [2203], 'Dynorphin': [2205], 'A-(1–8),': [2206], 'amastatin,': [2207], 'E64': [2209, 3205], 'Sigma,': [2213], 'actinonin': [2215, 3136], 'LKT': [2218], 'laboratories': [2219], '(St.': [2220], 'Paul,': [2221], 'MN).': [2222], 'Leupeptin,': [2223], 'pepstatin,': [2224], 'all': [2226, 4197], 'except': [2229], 'Institute.': [2237], 'Production': [2238], 'Recombinant': [2241], 'Laeverin/APQ—To': [2243], 'examine': [2244], 'detail,': [2251], 'tried': [2253], 'system.': [2264], 'To': [2265, 3383], 'facilitate': [2266], 'purification,': [2267], 'terminus': [2276, 3871], 'described': [2278], 'previously': [2279], 'APA.': [2286], 'Although': [2287, 2635, 3183], 'would': [2294], 'membrane-integral': [2301], 'protein,': [2302], 'mainly': [2307], 'detected': [2308, 3709, 3902, 3955, 4334], 'culture': [2310, 2342, 2358], 'secretory': [2314], 'rather': [2316], 'lysate': [2320], 'virus-infected': [2322], '(data': [2325, 2584, 2673, 2958, 3836, 4214], 'shown).': [2327, 2586, 2675, 2960, 3838, 4216], 'Consequently,': [2328, 3909], 'homogeneity': [2339], 'serial': [2345], 'chromatography': [2346], 'columns': [2348], 'Ni2+-chelating': [2352], 'Sepharose.': [2353], 'From': [2354, 2390], 'medium,': [2359], '∼1.0': [2360], 'mg': [2361], 'obtained.': [2365], 'gave': [2369], 'single': [2371], 'band': [2372], '∼120': [2378], 'kDa': [2379], 'SDS-PAGE': [2381], 'under': [2382], 'both': [2383, 2787, 4171, 4184], 'reducing': [2384], 'non-reducing': [2386], 'conditions': [2387], '(Fig.': [2388, 2616, 3696, 3703, 3713, 3758, 3853, 3911, 3919, 3949, 3972, 3981], '1A).': [2389], 'analysis,': [2395], 'homogenous': [2397], 'residues': [2403, 2822, 2825, 3849, 4242], '(65KPTPTPKPSS74)': [2404], 'obtained,': [2406], 'proteolytically': [2412], 'processed': [2413], 'preparation': [2420], 'process.': [2421], 'there': [2423], '15': [2425], 'potential': [2426], 'N-glycosylation': [2427], 'sites': [2428], 'sLaeverin/APQ,': [2433, 3020], 'next': [2435, 2677, 2944, 3856, 4227], 'examined': [2436, 2945, 3388, 3631, 3728, 3857, 4162, 4228], 'whether': [2437, 3729, 3807], 'N-glycosylated': [2440, 2477], 'not.': [2442], 'As': [2443, 3165, 3404, 3646, 3740, 3881, 3927], 'Fig.': [2446, 3106, 3649, 3884, 4248], '1B,': [2447], 'sensitive': [2451], 'F,': [2454], 'weight': [2458, 2564], 'de-glycosylated': [2460], 'shifted': [2462], '106': [2464], 'kDa,': [2465], 'identical': [2468], 'value,': [2472], 'indicating': [2473, 2652, 3677], 'expected.': [2479], 'homodimer': [2481], 'formation': [2482], 'feature': [2486], 'membrane-bound': [2489], '(23Matsumoto': [2494], 'Yamashiro': [2498, 3309, 4109], 'Kodama': [2500, 3311, 4111], 'Takio': [2506, 3317, 4117], '267:': [2516, 3327, 4127], '46-52Crossref': [2517, 3328, 4128], '(102)': [2520, 3331, 4131], '24Goto': [2523, 3334, 4134], 'Ishii': [2527, 3050, 3338, 3580, 3782, 4138], '2006;': [2536, 3059, 3347, 3589, 3791, 4147], '281:': [2537, 3060, 3348, 3590, 3792, 4148], '23503-23513Abstract': [2538, 3061, 3349, 3591, 3793, 4149], '(51)': [2546, 3069, 3357, 3599, 3801, 4157], '25Danielsen': [2549], 'E.M.': [2550], 'Biochemistry.': [2551], '1990;': [2552], '29:': [2553], '305-308Crossref': [2554], '(32)': [2557], 'Scholar),': [2559, 3601], 'gelfiltration': [2568], 'between': [2576, 2820], 'ferritin': [2577], '(440': [2578], 'kDa)': [2579, 2583], 'catalase': [2581], '(232': [2582], 'non-sulfide-linked': [2594], 'homodimeric': [2595], 'protein.': [2596], 'Characterization': [2597], 'Laeverin/APQ—We': [2602, 3365], 'relative': [2606], 'hydrolytic': [2607, 2798, 2975, 3421, 3495, 3658, 4252], 'aminoacyl-MCAs': [2615], '2).': [2617, 3403], 'substrates': [2620, 2690, 2775, 2789, 2802, 3411, 3625, 3852], 'tested,': [2621], 'Leu-MCA': [2622, 2669, 2711, 2742, 2974, 3397, 3446, 3494, 3657], 'hydrolyzed': [2624], 'most': [2627, 2708, 3119], 'efficiently,': [2628, 3425], 'followed': [2629], 'Lys-MCA.': [2634], 'showing': [2636], 'lower': [2637, 2747], 'activity,': [2638], 'hydrolysis': [2640, 3401, 3447, 3609, 3746], 'Phe-,': [2642], 'S-benzyl-Cys-,': [2643], 'Gln-MCA': [2646], 'observed,': [2651], 'enzyme.': [2659, 3382, 3628, 3770], 'optimal': [2661], 'pH': [2662], '7.0': [2667], 'We': [2676, 2943, 2961, 3804, 4180], 'activities': [2684], '(Table': [2691, 3402], '1).': [2692], 'values': [2699, 2754, 2878, 2886, 2896, 2929, 3500, 3558], 'plot': [2703], 'efficient': [2709], '78.2': [2713], '±': [2714, 2718, 2723, 2762, 2767, 2881, 2889, 2899, 2904, 2906, 2908, 2910, 2912, 2914, 2916, 2918, 2920, 2922, 2924, 2926, 2932, 2985, 2992, 2999, 3007, 3127, 3140, 3145, 3159, 3503, 3509, 3512, 3515, 3517, 3520, 3523, 3526, 3529, 3532, 3535, 3537, 3540, 3542, 3544, 3547, 3549, 3551, 3555, 3561, 3833, 4206, 4210], '5.5': [2715], '14.4': [2717], '0.6': [2719], 's–1,': [2720, 2726], '184': [2722], '4.6': [2724], 'μm–1': [2725], 'respectively.': [2727], 'catalytic': [2729], 'efficiency': [2730], '(kcat/Km)': [2731], 'Met-MCA': [2735], '∼23%': [2737], 'value': [2740, 3830], 'due': [2743], 'significantly': [2746, 3198], 'kcat': [2748], 'value.': [2749], 'contrast,': [2751, 3460], 'Km': [2753], 'Lys-': [2758], 'Arg-MCA': [2760], '(41.5': [2761], '5.1': [2763], 'μm': [2764, 3142, 3485, 3616, 3835], '34.9': [2766], '1.7': [2768], 'μm)': [2769, 3009, 3161], 'higher': [2771], 'affinity': [2772], 'Leu-MCA.': [2777, 2811], 'turnover': [2781], 'numbers': [2782], 'basic': [2788, 2824, 3846, 3865], 'less': [2792, 2807, 3163, 3430, 3481], 'Leu-MCA,': [2796], 'efficiencies': [2799], 'inversion': [2814], 'phenomenon': [2815], 'kinetics': [2818], 'neutral': [2821], 'observed': [2827, 3085, 3449, 3672, 3968], 'shows': [2835, 4250], 'highest': [2837], 'homology': [2838], '(∼36%)': [2839], 'among': [2842], 'members': [2845], '(26Turner': [2846], 'A.J.': [2847, 2849], 'Barret': [2848], 'Rawlings': [2850], 'N.D.': [2851], 'Woessner': [2852], 'J.F.': [2853], 'Handbook': [2854], 'Proteolytic': [2856], 'Enzymes.': [2857], '2nd.': [2858], 'Ed.': [2859], 'Academic': [2860], 'Press': [2861], 'Inc.,': [2862], 'San': [2863], 'Diego,': [2864], 'CA2004:': [2865], '289-294Crossref': [2866], '(16)': [2868], 'Scholar).TABLE': [2870], '1Kinetic': [2871], 'aminoacyl-MCASubstrateKmaThe': [2877], 'mean': [2880, 2888, 2898, 2931, 3502, 3560], 'S.D.': [2882, 2890, 2900, 2933, 3504, 3562], '(n': [2883, 2891, 2901, 2934, 3505, 3563], '=': [2884, 2892, 2902, 2935, 2983, 2990, 2997, 3005, 3125, 3138, 3157, 3506, 3564, 4204], '3).kcataThe': [2885], '3).kcat/Km': [2893], '103aThe': [2895], '3).μms-1μm-1·s-1Leu-MCA78.2': [2903], '5.514.4': [2905], '0.6184': [2907], '4.6Met-MCA77.0': [2909], '5.43.3': [2911], '0.242.4': [2913], '0.8Lys-MCA41.5': [2915], '5.12.7': [2917], '0.264.3': [2919], '3.6Arg-MCA34.9': [2921], '1.72.9': [2923], '0.183.6': [2925], '3.3a': [2927], '3).': [2936, 3565], 'Open': [2937, 3566], 'table': [2938, 3567], 'new': [2941, 3570], 'tab': [2942, 3571], 'effects': [2947, 3014, 3091, 3221, 3488], 'divalent': [2950], 'cations': [2951], 'Zn2+,': [2964], 'effective': [2966], 'inhibitor': [2967, 3121, 3152, 3814, 3824], 'suppressed': [2972, 3195], 'dose-dependent': [2980], 'manner': [2981], '(IC50': [2982, 2989, 2996, 3004], '6.6': [2984], '1.1': [2986], 'μm).': [2987, 3129], 'Cu2+': [2988], '19.6': [2991], '3.6': [2993], 'μm),': [2994, 3001], 'Co2+': [2995], '84.9': [2998], '12.2': [3000], '28.2': [3006], '3.7': [3008], 'moderate': [3012, 3437, 3843, 4222], 'inhibitory': [3013, 3220, 3438, 3482], 'consistent': [3023], 'so': [3029], 'far': [3030], 'tested.': [3031], 'our': [3033, 3574], 'previous': [3034], 'work,': [3035], 'Ca2+': [3036, 3077], 'modulate': [3040], 'APA': [3045, 3154, 3777], '(24Goto': [3046, 3576, 3778], 'no': [3073, 3665], 'significant': [3074, 3666], 'effect': [3075], 'up': [3086, 3673], 'mm.': [3089, 3182, 3224], 'protease': [3095, 3187, 3193, 3208, 3215], 'inhibitors': [3096, 3133, 4202], '3.': [3107], 'bestatin,': [3112], 'competitive': [3114, 3823, 4201], 'inhibitor,': [3116], 'potent': [3120], '(Ki': [3124, 3137, 3156, 4203], '0.96': [3126], '0.33': [3128], 'APN': [3132], 'phebestin': [3134], '3.02': [3139], '0.61': [3141], '259': [3144], '30.7': [3146], 'respectively)': [3148, 4213], 'amastatin': [3155], '34.5': [3158], '10.0': [3160], 'active.': [3164], '1,10-phenanthroline,': [3173], 'metal': [3175], 'chelator,': [3176], '0.01–1': [3181], 'leupeptin': [3184], '(a': [3185, 3206, 3213], 'serine': [3186, 3214], 'inhibitor)': [3188, 3194, 3209, 3216], 'pepstatin': [3190], '(an': [3191], 'asparatic': [3192], 'only': [3199, 3218], 'high': [3201], '(1': [3203], 'mm),': [3204], 'cysteine': [3207], 'small': [3219], '1': [3223], 'Taken': [3225], 'together,': [3226], 'data': [3228], 'indeed': [3233], 'having': [3238, 3864], '(7Tanioka': [3246, 4046], '23Matsumoto': [3305, 4105], 'Natural': [3362], 'searched': [3367], 'sLaeverin/APQ-mediated': [3369, 3445, 3691], 'degradation': [3370, 3667, 3717, 3749, 3859, 3977], 'estimate': [3376], 'identify': [3384], 'competition': [3390], '18': [3392], 'measuring': [3399], 'often': [3409], 'good': [3410, 3889], 'Ang': [3415, 3427, 3652, 3679, 3694, 3701, 3732, 3744, 3751, 3762, 3771, 3810], 'IV': [3418, 3702, 3733, 3752, 3763, 3772, 3811], 'effective.': [3431], 'Bradykinin': [3432], 'substance': [3434, 3879, 4168], 'P': [3435], 'activities.': [3439], 'Furthermore,': [3440], 'strong': [3441], 'inhibition': [3442, 3606], 'kallidin': [3451, 3873, 3886, 3899, 3910], '(Lys-bradykinin),': [3452, 3874], 'A1–8,': [3456, 4235], 'kisspeptin-10.': [3458], 'nine': [3461], '(Met-enkephalin,': [3464], 'D,': [3466], 'Arg-vasopressin,': [3467], 'parathyroid': [3468], 'hormone-(69–84),': [3469], 'cholecystokinin-8,': [3470], 'neurokinin': [3471, 3473], 'A,': [3472], 'B,': [3474], 'oxytocin,': [3475], 'delta': [3477], 'sleep-inducing': [3478, 3553], 'peptide)': [3479], '(<50%).TABLE': [3486], '2Competitive': [3487], 'sLaeverin/APQPeptideSequenceLeu-MCA': [3498], 'hydrolysis%aThe': [3499], '3).Ang': [3507], 'IIDRVYIHPF68.1': [3508], '2.7Ang': [3510], 'IIIRVYIHPF11.9': [3511], '1.5Ang': [3513], 'IVVYIHPF18.0': [3514], '0.6BradykininRPPGFSPFR37.8': [3516], '1.3Kallidin': [3518], '(Lys-bradykinin)KRPPGFSPFR2.8': [3519], '0.3Substance': [3521], 'PRPKPQQFFGLM—NH215.0': [3522], '0.8Neurokinin': [3524], 'AHKTDSFVGLM—NH271.6': [3525], '2.9Neurokinin': [3527], 'BDMHDFFVGLM—NH255.4': [3528], '0.7Endokinin': [3530, 3533], 'CKKAYQLEHTFQGLL—NH22.5': [3531], 'DVGAYQLEHTFQGLL—NH262.6': [3534], '6.0Met-enkephalinYGGFM62.5': [3536], '10.5Dynorphin': [3538], 'A1-8YGGFLRRI3.9': [3539], '0.6Arg-vasopressinCYFQNCPRG—NH285.6': [3541], '5.9OxytocinCYIQNCPLG—NH286.2': [3543], '2.0Parathyroid': [3545], 'hormone-(69-84)EADKADVNVLTKAKSQ91.0': [3546], '1.2Cholecystokinin-8DYMGWMDF—NH273.2': [3548], '0.6Kisspeptin-10YNWNSFGLRF—NH23.4': [3550], '0.1Delta': [3552], 'peptideWAGGDASGQ88.4': [3554], '10.1a': [3556], 'Based': [3572], 'experience': [3575], 'show': [3604], '>50%': [3605], 'assay': [3619], 'could': [3620], 'assumed': [3622], 'Therefore,': [3629, 3726], 'cleavage': [3633, 3692, 4230], 'candidate': [3635, 3862], 'detecting': [3638], 'degraded': [3639, 4343], 'separating': [3642], 'reverse-phase': [3644], 'HPLC.': [3645], '4A,': [3650], 'slightly': [3654], 'hormone': [3670], '6': [3675], 'h,': [3676], 'On': [3687], 'hand,': [3690], '4B,': [3697, 3704], 'peak': [3698, 3705, 3913, 3921, 3951, 3974, 3983], 'a)': [3699, 3914], 'b)': [3706, 3922, 3952], 'clearly': [3708], 'within': [3710, 3903, 3924, 3956, 4335], '4B).': [3714], 'did': [3718], 'occur': [3720], 'longer': [3722], 'incubation': [3723], '(6': [3724], 'h).': [3725], 'can': [3734], 'sLaeverin/APQ.': [3739], 'profile,': [3747], 'barely': [3756], 'detectable': [3757], '4C),': [3759], 'inhibit': [3776], 'therefore': [3805], 'tested': [3806], 'Ki': [3829], '8.96': [3832], '1.07': [3834], '2),': [3854], 'acids': [3867], '(i.e.': [3872], 'bradykinin,': [3877], 'P).': [3880], '5A,': [3885, 3912, 3920], 'release': [3892, 3934, 4035], 'lysine': [3896, 3938, 3998], 'residue': [3897, 3939, 3999, 4040, 4045, 4330], '(Lys-bradykinin)': [3900], 'assay.': [3908], 'converted': [3916], 'bradykinin': [3918, 4166], 'completely': [3923], '30': [3925, 3970], 'rapid': [3933], 'generation': [3944], 'de-[Lys]endokinin': [3946, 3965], '(36%)': [3948], '5B,': [3950, 3973, 3982], 'Of': [3959], 'note,': [3960], 'transient': [3962], 'accumulation': [3963], 'b),': [3975], 'de-[Lys-Lys]endokinin': [3979], 'c)': [3984], 'seemed': [3985], 'slower': [3989], 'cleavage,': [3993], 'second': [3997], 'poorer': [4002], 'one.': [4009], 'plausible': [4012], 'subsite': [4014], 'interactions': [4015], 'required': [4017], 'been': [4026], 'adjacent': [4041], 'proline': [4044], 'Therefore': [4160], 'susceptibilities': [4164], 'P,': [4169], 'Arg-Pro': [4173], 'termini': [4177], 'that,': [4182], 'bind': [4186], 'they': [4189], 'cleaved': [4192], 'acted': [4199], '57.8': [4205], '11.0': [4207], '4.63': [4209], '0.49': [4211], 'Phe-MCA,': [4225], 'tyrosine': [4244, 4329], '(aromatic': [4245], 'acid).': [4247], '6A': [4249], 'profile': [4253], 'abundant': [4258], 'placenta': [4261], 'suppresses': [4263], 'motility': [4266], 'strongly': [4267], 'G-protein-coupled': [4272], 'GPR54': [4274], '(27Ohtaki': [4275], 'Shintani': [4277], 'Honda': [4279], 'Hori': [4283], 'Kanehashi': [4285], 'Terao': [4287], 'Kumano': [4289], 'Takatsu': [4291], 'Ishibashi': [4295], 'Watanabe': [4297], 'Asada': [4299], 'Suenaga': [4303], 'Kitada': [4305], 'Usuki': [4307], 'Kurokawa': [4309], 'Onda': [4311], 'Nishimura': [4313], 'Fujino': [4315], 'Nature.': [4317], '613-617Crossref': [4320], '(1195)': [4322], 'Release': [4325], 'min,': [4337], '∼30%': [4339], 'de-[Tyr]kisspeptin-10': [4345], '(': [4346]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2092188551', 'counts_by_year': [{'year': 2024, 'cited_by_count': 4}, {'year': 2023, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 4}, {'year': 2020, 'cited_by_count': 6}, {'year': 2019, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 3}, {'year': 2014, 'cited_by_count': 4}, {'year': 2013, 'cited_by_count': 1}, {'year': 2012, 'cited_by_count': 4}], 'updated_date': '2024-12-29T17:07:15.172998', 'created_date': '2016-06-24'}
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